26th week of 2010 patent applcation highlights part 60 |
Patent application number | Title | Published |
20100168364 | MULTI-BRANCHED POLYPROPYLENE - Multi-branched polypropylene having a g′ of less than 1.00 | 2010-07-01 |
20100168365 | Production Process of Glucan Derivative Modified With Cyclic Ester - Disclosed is a method for producing a cyclic ester-modified glucan derivative wherein generation of homopolymers of the cyclic ester can be highly suppressed. Specifically disclosed is a method for producing a modified glucan derivative to which a cyclic ester is graft-polymerized, wherein a glucan derivative having a hydroxyl group and a cyclic ester are reacted in a solvent in the presence of a ring-opening polymerization catalyst. In this method, (1) the ring-opening polymerization catalyst is composed of a metal complex which does not initiate polymerization of the cyclic ester by itself; (2) the solvent is composed of an aromatic hydrocarbon solvent having a solubility in water at 20° C. of not more than 10% by weight; and (3) the ratio of the solvent is set at not less than 60 parts by weight per 100 parts by weight of the glucan derivative having a hydroxyl group. | 2010-07-01 |
20100168366 | NOVEL SYNTHETIC N-LINKED SIALO-GLYCAN-CONTAINING POLYMER AND METHOD FOR PRODUCING THE SAME - A polymer containing an N-linked sialo-glycan wherein a sialo-glycan is condensed to a γ-polyglutamic acid using a chemical compound having an amino group on one end and a carboxyl group on another end and represented by the structural formula (I). Formula (I) (In the formula, Z means a hydroxy group or a residue represented by the formula (II), and n represents an integer of 10 or more, with the proviso that any one or more of the Z's is represented by the formula in (II).) Formula (II) (In the formula, X means a hydroxy group or an acetylamino group, Y | 2010-07-01 |
20100168367 | NOVEL POLYETHER SILOXANE-CONTAINING ALKOXYLATION PRODUCTS BY DIRECT ALKOXYLATION OF ORGANOMODIFIED a,w-DIHYDROXYSILOXANES OVER DOUBLE METAL CYANIDE (DMC) CATALYSTS, AND ALSO PROCESS FOR PRODUCING THEM - Novel silicone polyethers by alkoxylating polymerization of epoxide monomers with (poly)organosiloxanes starting from an α,ω-dihydroxysiloxane as starter by means of DMC catalysis and process for preparing them. | 2010-07-01 |
20100168368 | Epoxy Resin, Method for Producing Same and Epoxy Resin Composition Thereof - An epoxy resin represented by general formula (I), which satisfies numerical formula (1) mentioned below and comprises hydrolytic halogen of 0.05 wt. % or less, said epoxy resin being produced by the procedure as follows: after dissolving 0.8 to 1.3 mole of epihalohydrin to 1 mole of divalent phenol in a solvent, a pre-reaction is performed over 30 to 70 minutes by adding dropwise 0.25-0.35 mole of 30˜50% aqueous solution of alkali metal hydroxide over 30 to 70 minutes thereto, and thereafter, 0.65-0.75 mole of the remaining 30˜50% aqueous solution of alkali metal hydroxide is added dropwise over about 1 hour to complete the reaction over 1 to 3 hours. | 2010-07-01 |
20100168369 | METHOD FOR PRODUCING AROMATIC POLYMER - A method for producing an aromatic polymer including polycondensing an aromatic compound represented by the following general formula (I) in the presence of a nickel complex containing a phosphine compound represented by the following general formula (II). | 2010-07-01 |
20100168370 | TRANSPARENT ARTICLES PREPARED FROM THERMOPLASTIC COMPOSITIONS HAVING HIGH FLOW AND DUCTILITY, AND METHOD OF PREPARING ARTICLES - Disclosed herein is a camera lens comprising a thermoplastic composition comprising a poly(aliphatic ester)-polycarbonate copolymer comprising soft block ester units derived from an alpha, omega C | 2010-07-01 |
20100168371 | Bio-Based Terephthalate Polyesters - Bio-based terephthalic acid (bio-TPA), bio-based dimethyl terephthalate (bio-DMT), and bio-based polyesters, which are produced from a biomass containing a terpene or terpenoid, such as limonene are described, as well as the process of making these products. The bio-based polyesters include poly(alkylene terephthalate)s such as bio-based poly(ethylene terephthalate) (bio-PET), bio-based poly(trimethylene terephthalate) (bio-PTT), bio-based poly(butylene terephthalate) (bio-PBT), and bio-based poly(cyclohexylene dimethyl terephthalate) (bio-PCT). | 2010-07-01 |
20100168372 | Bio-Based Terephthalate Polyesters - Bio-based terephthalic acid (bio-TPA), bio-based dimethyl terephthalate (bio-DMT), and bio-based polyesters, which are produced from a biomass containing a terpene or terpenoid, such as limonene are described, as well as the process of making these products. The bio-based polyesters include poly(alkylene terephthalate)s such as bio-based poly(ethylene terephthalate) (bio-PET), bio-based poly(trimethylene terephthalate) (bio-PTT), bio-based poly(butylene terephthalate) (bio-PBT), and bio-based poly(cyclohexylene dimethyl terephthalate) (bio-PCT). | 2010-07-01 |
20100168373 | Bio-Based Terephthalate Polyesters - Bio-based terephthalic acid (bio-TPA), bio-based dimethyl terephthalate (bio-DMT), and bio-based polyesters, which are produced from a biomass containing a terpene or terpenoid, such as limonene are described, as well as the process of making these products. The bio-based polyesters include poly(alkylene terephthalate)s such as bio-based poly(ethylene terephthalate) (bio-PET), bio-based poly(trimethylene terephthalate) (bio-PTT), bio-based poly(butylene terephthalate) (bio-PBT), and bio-based poly(cyclohexylene dimethyl terephthalate) (bio-PCT). | 2010-07-01 |
20100168374 | Diamine compound having dendron side chain and liquid crystal aligning agent using same - Disclosed herein is a novel functional diamine compound having a dendron structure, polyamic acid which is produced using functional diamine, aromatic cyclic diamine, aliphatic cyclic acid dianhydride, and aromatic cyclic acid dianhydride, polyimide which is produced by imidizing polyamic acid, and an LC alignment film produced using polyimide. Even if the diamine compound is used in a small amount, it is possible to realize a high pretilt angle, thus the pretilt angle is easily controlled. Therefore, it can be used to produce an LC alignment film using a twisted nematic (TN) mode, in which the pretilt angle of liquid crystal is low, and a vertically aligned (VA) mode, which requires a high pretilt angle of about 90°. | 2010-07-01 |
20100168375 | PRODUCTION OF SOLUTIONS OF DIACID/DIAMINE SALTS - Solutions of a salt of a diamine and of a diacid, more particularly concentrated solutions of hexamethylene diammonium adipate salt (“nylon salt”), useful starting materials for the production of polyamides, more specifically of PA66, are prepared by mixing a diacid and a diamine, at a salt concentration by weight of from 50% to 80%, in a first stage, to provide aqueous solutions of diacid and diamine having a diacid/diamine molar ratio of greater than 1.1 and, in a second stage, adjusting the diacid/diamine molar ratio, by adding diamine, to a value of from 0.9 to 1.1, preferably from 0.99 to 1.01, and in fixing the salt concentration by weight by, optionally, adding water thereto. | 2010-07-01 |
20100168376 | PRODUCTION OF A FUNCTIONALIZED POLYTRIAZOLE POLYMER - A method for the production of a functionalized polytriazole polymer, particularly a poly(1,2,4-triazole)-polymer, includes the steps of (a) mixing a hydrazine salt, particularly hydrazine sulfate, with at least an aromatic and/or heteroaromatic dicarboxylic acid and/or at least a dicarboxylic acid derivate in polyphosphoric acid and if necessary further components for obtaining a solution; (b) heating the solution in a protective gas atmosphere for obtaining polyhydrazides and adding aromatic and/or heteroaromatic primary amines to the solution; and (c) precipitating a polymer. If necessary, neutralization in a basic solution may be carried out. | 2010-07-01 |
20100168377 | Catalytic conversion of amide compounds to methyl ether polymers and methyl ether ladder polymers - Catalytic processes have been developed for direct chemical conversion of amides to methyl ether polymers or methyl ether ladder polymers. Amides formed by reacting acetic acid with monoethanol amine (MEA) or acetic acid with butylamine were polymerized in the presence of transition metal catalysts in air to form linear polymers. Ethanol acetamide was catalytically converted to a linear polyether as characterized by FTIR spectra. The catalysts were based on molecular strings of mono-, di- or tri-valent transition metal compounds that opened the amide carbonyl double bond to produce linear polyethers. Laboratory results have demonstrated [cobalt(II)] | 2010-07-01 |
20100168378 | POLYMERS FUNCTIONALIZED WITH NITROSO COMPOUNDS - A method for preparing a functionalized polymer, the method comprising the steps of: (i) polymerizing monomer with a coordination catalyst to form a reactive polymer; and (ii) reacting the reactive polymer with a nitroso compound. | 2010-07-01 |
20100168379 | Epichlorohydrin, manufacturing process and use - Product containing epichlorohydrin, wherein the amount of trichloropropane is of less than 0.01 g of trichloropropane per kg of product, a process for manufacturing the product and its use in various applications. | 2010-07-01 |
20100168380 | PROCESS FOR SYNTHESIZING CYCLIC PEPTIDE COMPOUND - The objective is to provide a novel process for synthesizing a cyclic peptide compound. It is also an objective to provide a novel cyclic peptide compound. The novel process for synthesizing a cyclic peptide compound comprises the steps of: (1) translationally synthesizing a non-cyclic peptide compound having in a molecule a functional group 1 and a functional group 2, which are a pair of functional groups capable of reacting to form a bond, and (2) cyclizing the non-cyclic peptide compound by the reaction of the functional groups 1 and 2 to form a bond. The novel cyclic peptide compound can be synthesized by the process. | 2010-07-01 |
20100168381 | CONJUGATES OF MEMBRANE TRANSLOCATING AGENTS AND PHARMACEUTICALLY ACTIVE AGENTS - Membrane translocation peptides, compositions comprising them, chimeric molecules comprising them, and methods of using them to achieve transmembrane transport of various agents. | 2010-07-01 |
20100168382 | NEUROPLASTIN DERIVED PEPTIDES - The present invention relates to peptides derived from neuroplastin which are capable of inducing neurite outgrowth by modulating intracellular calcium concentration and activity of intracellular signalling molecules such as Akt, Erk1/2 and CREB through binding and/or modulation of receptor tyrosine kinases including but not limited to Fibroblast Growth Factor receptors (FGFRs). The peptides are derived from neuroplastin or fragments thereof. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein neuroplastin and/or receptor tyrosine kinases, including but not limited to FGFRs, play a prominent role. | 2010-07-01 |
20100168383 | Skin or Hair Binding Peptides - The invention is directed to peptides. Specifically, the invention is directed to peptides which bind skin and do not bind hair. Alternatively, the invention is drawn to peptides which bind hair and do not bind skin. | 2010-07-01 |
20100168384 | ANTI-VIRAL COMPOUNDS - Compounds capable of inhibiting replication of the hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. | 2010-07-01 |
20100168385 | PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED AMINO-ALCOHOLS - A process for preparing an enantiomerically enriched amino alcohol or derivatives thereof having the structure: | 2010-07-01 |
20100168386 | FUSION PROTEIN CARRYING NEUROTROPHIN ACROSS THE BLOOD-BRAIN BARRIER, ENCODING GENE AND USES THEREOF - Provided are fusion proteins which comprise a first region having at least 75% homology with the amino acid sequence of neurotrophin, and a second region, located at the C-terminal of the first region, having at least 75% homology with the amino acid sequence of protein transduction domain (PTD). Also provided is encoding gene and usage thereof. The fusion protein can translocate through cell membrane or even the blood-brain barrier (BBB). The fusion protein can be used to treat various central nervous system degenerative diseases and peripheral neuropathy. | 2010-07-01 |
20100168387 | Chimeric CrylE Delta Endotoxin and Methods of Controlling Insects - The present invention relates to a chimeric δ endotoxin protein Cry 1E of SEQ ID No. 1 with extraordinarily high insecticidal property and a chimera gene of SEQ ID No. 2 encoding the said chimeric protein, and also a method of treating insect infested plants using said chimera protein. | 2010-07-01 |
20100168388 | STABILIZED P53 PEPTIDES AND USES THEREOF - Cross-linked peptides related to human p53 and bind to HMD2 or a family member of HDM2 useful for promoting apoptosis, e.g., in the treatment of and identifying therapeutic agents that binding to HMD2 or a family member of HDM2. | 2010-07-01 |
20100168389 | PROCESS FOR PRODUCING EXTRACT FOR CELL-FREE PROTEIN SYNTHESIS AND CELL EXTRACT PRODUCED THEREBY - It is intended to provide a process for producing an extract for cell-free protein synthesis whereby the productivity of a protein and the production efficiency can be improved. Cells are cultured under suppressed growth conditions. In the stationary phase of the culture, the cells are collected and then disrupted. The above-described cells are preferably bacterial cells, in particular, | 2010-07-01 |
20100168390 | MHC MULTIMERS, METHODS FOR THEIR GENERATION, LABELING AND USE - The present invention describes novel methods to generate MHC multimers and methods to improve existing and new MHC multimers. The invention also describes improved methods for the use of MHC multimers in analysis of T-cells in samples including diagnostic and prognostic methods. Furthermore the use of MHC multimers in therapy are described, e.g. anti-tumour and anti-virus therapy, including isolation of antigen specific T-cells capable of inactivation or elimination of undesirable targeT-cells or isolation of specific T-cells capable of regulation of other immune cells. | 2010-07-01 |
20100168391 | Pegylated Factor VIII - The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII. | 2010-07-01 |
20100168392 | EXPRESSION OF FULL LENGTH IGG AND SECRETION INTO THE CULTURE MEDIUM OF PROKARYOTIC CELLS - A method for the production of an immunoglobulin or a functional fragment thereof in a prokaryotic host cell comprises transforming the host cell with (a) a first nucleic acid molecule comprising a nucleic acid sequence encoding a V | 2010-07-01 |
20100168393 | Antibody Polypeptide Libray Screening and Selected Antibody Polypeptides - The present invention provides further developments in the screening of antibody polypeptide libraries. The invention also provides novel isolated antibody polypeptides obtainable by the methods of the invention. | 2010-07-01 |
20100168394 | Antibody modulating the differentiation and function of dendritic cells via binding intercellular adhesion molecule-1 and use thereof - The present invention relates to an antibody binding to human intercellular adhesion molecule-1 (ICAM-1) where the antibody is able to modulate the differentiation status of dendritic cells and prolong the graft survival. In addition, the present invention provides a pharmaceutical composition comprising the antibody, and method of using them for the treatment of disease. | 2010-07-01 |
20100168395 | NOVEL POLYPEPTIDE, AN AFFINITY CHROMATOGRAPHY MATERIAL, AND A METHOD FOR SEPARATING AND/OR PURIFYING IMMUNOGLOBULIN - [Object] The aim of the present invention is to develop a novel immunoglobulin binding polypeptide, the loss and formation of whose native three dimensional structure can be controlled under the conditions where unwanted effects such as damages, loss of functions or unintended functions do not occur to immunoglobulin (pH 5-9, lower than 60° C.), and use thereof as a ligand coupled to an affinity chromatography support. | 2010-07-01 |
20100168396 | Novel Branchiostoma Derived Fluorescent Proteins - The present invention provides compositions, combinations, methods, sequences and kits for use of novel fluorescent proteins derived from the genus | 2010-07-01 |
20100168397 | THERAPEUTIC USE OF ANTI-CS1 ANTIBODIES - The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including autoimmune disorders and cancer, in a subject in need thereof, comprising administering into said subject an effective amount of such antagonists. | 2010-07-01 |
20100168398 | Method, computing routine, device for predicting properties of MHC/peptide complexes, and data and peptides produced therefrom. - The present invention relates to a method for structure-based prediction of properties of peptides and peptide analogs in complex with major histocompatibility (MHC) class I and class II molecules. The said properties mainly relate to the three-dimensional structure of an MHC/peptide complex and the binding affinity of a peptide for an MHC receptor. The invention further relates to a computer program and a device therefor. The invention further relates to data produced by a method of the invention. The invention further relates to peptides and peptide analogs predicted to bind to target-MHC molecules. The present invention thus relates to the field of immunology, with possible applications in manufacture of vaccinates, de-immunization of proteins, and manufacture of therapeutic agents, especially immunotherapeutic agents. | 2010-07-01 |
20100168399 | ANTIBODIES THAT BIND B7L-1 - The invention is directed to B7L-1 as a purified and isolated protein, the DNA encoding the B7L-1, host cells transfected with cDNAs encoding B7L-1 and processes for preparing B7L-1 polypeptides. | 2010-07-01 |
20100168400 | Superagonistic Anti-CD28 Antibodies - The present invention relates to one or more nucleic acid(s) encoding a binding molecule specifically binding to a human CD28 molecule, comprising
| 2010-07-01 |
20100168401 | Method, composition and kit for detecting phosphatidylserine (PS) on cell membranes - A method, composition and kit for detecting the presence of a phospholipid, such as phosphatidylserine, on a cell membrane is provided. A binding agent including lactadherin, a fragment of lactadherin, a functional equivalent of lactadherin, or a functional equivalent of a fragment of lactadherin, is used to detect the presence of any phospholipid. | 2010-07-01 |
20100168402 | Direct Attachment of Polypeptides to Virus Like Particles - Compositions and methods are provided for the control of direct protein attachment to virus like particles where virus structural proteins that have been modified to comprise an unnatural amino acid at a pre-determined site are reacted with one or more “display” polypeptides that also comprise an unnatural amino acid at a pre-determined site in a one step reaction. The compositions of the invention are useful for various purposes where it is desirable to efficiently and directly attach multiple polypeptides to a single carrier entity, particularly where two or more different polypeptides are attached to a single carrier. | 2010-07-01 |
20100168403 | Protein refolding agent and refolding method - A refolding agent and refolding method which makes it possible to produce high-purity proteins in high productivity. The refolding agent includes a phosphorus-containing compound (A) and an oxycarbonyl group-containing compound (B). The refolding method includes the step of treating the unfolded protein with the refolding agent. As the compound (A), there may be at least one selected from inorganic phosphoric acids, alkyl phosphate esters, sugar phosphate esters, and salts of these, and as the compound (B), there may be at least one selected from formic acid, acetic acid, propionic acid, lactic acid, tartaric acid, and salts of these. | 2010-07-01 |
20100168404 | Metal Complex Compositions and Methods for Making Metal-Containing Films - The present invention provides compositions of matter useful as deposition agents for making structures, including thin film structures and hard coatings, on substrates and features of substrates. In an embodiment, for example, the present invention provides metal complexes having one or more diboranamide or diboranaphosphide ligands that are useful as chemical vapor deposition (CVD) and/or atomic layer deposition (ALD) precusors for making thin film structures and coatings. Metal complex CVD precursors are provided that possess volitilities sufficiently high so as to provide dense, smooth and homogenous thin films and coatings. | 2010-07-01 |
20100168405 | ACTIVATOR INCLUDING BIOSURFACTANT AS ACTIVE INGREDIENT, MANNOSYL ERYTHRITOL LIPID, AND PRODUCTION METHOD THEREOF - The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism. | 2010-07-01 |
20100168406 | USE OF GINSENOSIDE Rb2 MONOMER IN THE MANUFACTURE OF MEDICAMENTS FOR THROMBOLYSIS - The present invention discloses use of ginsenoside Rb | 2010-07-01 |
20100168407 | Quaternized Carboxymethyl Chitosan Derivatives and Preparation Method Thereof - The invention relates to a novel kind of chitosan derivative, specifically to quaternized carboxymethyl chitosand derivatives and preparation method. Chitosan with different molecular weight reacts with chloroactic acid give rise to carboxymethyl chitosan. After reaction of Schiff based, deoxidized and quaternized, quaternized carboxymethyl chitosan is obtained. This kind of chitosan derivative have better water-solubility and better antifungal activity, which can used in the fields of medicine and agriculture. | 2010-07-01 |
20100168408 | COMPOSITIONS AND METHODS FOR LABELING OF NUCLEIC ACID MOLECULES - The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for to fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics. | 2010-07-01 |
20100168409 | THERMOPLASTIC RESIN FILM AND METHOD FOR PRODUCING SAME - To provide a thermoplastic resin film, and process for producing the same, which can obtain a film having high optical properties in which the occurrence of residual strain and the exhibition of retardation during film forming are suppressed. A film ( | 2010-07-01 |
20100168410 | Hydroxypropyl Methyl Cellulose Hard Capsules and Process of Manufacture - A composition for manufacture of hard hydroxypropyl methyl cellulose capsules comprising a film forming material of hydroxypropyl methyl cellulose having a methoxy content of 27.0-30.0% (w/w), and a hydroxypropoxy content of 4.0-7.5% and as a 2% weight solution, a viscosity of 3.5-6.0 cPs at 20° C., dipping compositions, process for manufacture of hard hydroxypropyl methyl cellulose capsules according to a dip coating process and hard capsule shells. | 2010-07-01 |
20100168411 | Method of producing fermentation product and fermentation product - Provided are a fermentation product, which shows a strong antioxidative effect and is efficacious against diseases caused by active oxygen, and a method of producing the same. Stems and leaves of a perennial gramineous plant (rice straw, reed, barely straw, etc.) are mixed with a fermentation medium which comprises egg albumen, egg yolk, rice bran and water optionally together with xylase and thus the stems and leaves of the perennial gramineous plant are decomposed. After conducting lactic acid fermentation, the contents of the fermentation tank are dried. The dry fermentation product thus obtained is extracted with water and the extract is filtered and then concentrated. | 2010-07-01 |
20100168412 | Continuous Neutralizer Mixer Reactor and a Continuous Process for Quenching Chlorination Reaction Mixture in Production of Chlorinated Sucrose - An improved process of production of a chlorinated sugar is described comprising chlorination of a partially protected sugar, wherein quenching as well as neutralization of chlorinated reaction mass is carried out concurrently and continuously in a reactor which is a continuous mixer as well as quencher providing continuous mixing of chlorination reaction mixture and pH adjusting solution and also provides for continuous quenching and continuous removal of quenched chlorinated reaction mixture. | 2010-07-01 |
20100168413 | ONE-POT SYNTHESIS OF BENZISOINDOLENINES USED IN THE PREPARATION OF NAPHTHALOCYANINES - A method of effecting a one-pot conversion of a tetrahydronaphthalic anhydride of formula (I): | 2010-07-01 |
20100168414 | PROCESSES FOR PREPARING EZETIMIBE AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION THEREOF - The invention relates, in general, to an improved process for converting compounds of Formula II (below) to compounds of Formula III (below), which are key intermediates for the synthesis of ezetimibe, or to ezetimibe itself, wherein in Formulas II and III, R represents hydrogen, alkyl, or a hydroxyl protecting group (e.g., benzyl group, a substituted benzyl group, or a silyl group). The invention further includes the use of the described process and the use of compounds of Formula III made by the described process for the preparation of ezetimibe. | 2010-07-01 |
20100168415 | Process for preparation of Caspofungin acetate - A process for making caspofungin acetate comprising the steps of:
| 2010-07-01 |
20100168416 | POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS - Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed. | 2010-07-01 |
20100168417 | 2-Indolyl Imidazo [4,5-d] Phenanthroline Derivatives and Their Use in the Treatment for Cancer - 2-indolyl imidazo[4,5-d]phenanthroline compounds of Formula I that are capable of intracellular chelation of transition metals and of exerting antiproliferative effects in cancer cells, that are cytostatic and/or cytotoxic, are provided. Compounds of Formula I can also induce apoptosis in cancer cells and are thus capable of exerting a cytotoxic effect on cancer cells. The compounds of Formula I are also capable of selectively inhibiting the proliferation of one or more of prostate cancer cells, colon cancer cells, non-small lung cancer cells and leukemia cells. The compounds of Formula I are also capable of increasing the expression of the zinc-regulated tumour suppressor, KLF4 and thus are useful in inhibiting the proliferation of cancer cells in which KLF4 functions as a tumour-suppressor, including, but not limited to, bladder cancer, cancers of the gastrointestinal tract and various leukemias. | 2010-07-01 |
20100168418 | NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF - A nitrogen-containing heterocyclic compound represented by the general formula: wherein the dashed line represents a single bond or a double bond; R | 2010-07-01 |
20100168419 | Diacylglycerol Acyltransferase Inhibitors - Provided herein are compounds of the formula (I): | 2010-07-01 |
20100168420 | Taxol Derivatives With Antitumor Activity - Taxol derivatives or their salts having the formula as following: Wherein, R | 2010-07-01 |
20100168421 | A NEW PEPTIDE DEFORMYLASE INHIBITOR COMPOUND AND MANUFACTURING PROCESS THEREOF - The present invention relates to the novel antibacterial compounds having potent antibacterial activity as inhibitors of peptide deformylase. This invention further relates to pharmaceutically acceptable salts thereof, to processes for their preparation, and to pharmaceutical compositions containing them as an active ingredient. | 2010-07-01 |
20100168422 | METHODS AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF HEXAHYDROFURO [2,3-B]FURAN-3-OL - Provided herein are compounds and methods useful for preparing hexahydrofuro[2,3-b]furan-3-ol. Hexahydrofuro[2,3-b]furan-3-ol can be efficiently synthesized in four steps from readily available starting materials. | 2010-07-01 |
20100168423 | METHOD FOR THE PRODUCTION OF BRIDGED DIBENZ[c,e] [1,2]-OXAPHOSPHORIN-6-OXIDES - The invention relates to an improved method for the synthesis of monomeric and polymeric nitrogen-bridged derivatives of dibenz[c,e][1,2]-oxaphosphorin-6-oxides. These substances can be used as flameproofing agents for polyesters, polyamides, polycarbonates, epoxy resins, inter alia polymers. | 2010-07-01 |
20100168424 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF - The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof | 2010-07-01 |
20100168425 | ANTIHISTAMINIC AND ANTIALLERGIC AGENT AND A METHOD FOR THE PRODUCTION THEREOF - The invention relates to a range of original xanthine derivatives substituted in 1- and 7-positions with benzhydryl-4-piperazinyl-1-alkane fragments. A method for obtaining 3-methyl-7-[4-(benzhydryl-4-piperazinyl-1)butyl]xanthine and the salts thereof with organic and inorganic acids by alkylating the 7-potassium salt of 3-methylxanthine by 1,4-dibromobutane, by subsequently interacting the thus formed 7-(4-bromobutyl)-3-methylxanthine with 1-benzhydrylpiperazinyl and by neutralising the thus obtained radical 7-/4-(4-benzhydrylpiperazinyl-1) butyl/-3-methylxanthine by an organic or inorganic acid is also disclosed. | 2010-07-01 |
20100168426 | NOVEL PROCESSES FOR THE PRODUCTION OF USEFUL INTERMEDIATES - The present application relates to a new process for the asymmetric production of 3-(pyridin-4-yl)-3-hydroxy-pentanoic acid derivatives, which are useful intermediates in the manufacture of compounds that are known to show antiproliferative activity. | 2010-07-01 |
20100168427 | METHOD FOR PRODUCING N-METHYLNALTREXONE BROMIDE - Process for the preparation of N-methylnaltrexone bromide, wherein a compound of the general formula (I): | 2010-07-01 |
20100168428 | ENVIRONMENTALLY SENSITIVE FLUOROPHORES - The present invention generally relates to environment-sensitive fluorophores, including environment-sensitive fluorophores for reporting protein/protein and peptide/protein interactions. In one aspect, the present invention is directed to compounds and salts thereof, compositions and methods useful in determining biological interactions. In some cases, the compounds of the present invention are environment-sensitive fluorophores that have spectroscopic behavior that may depend on factors such as the physicochemical properties of the surrounding environment. The compounds of the present invention can be used, in certain embodiments, to monitor ions, small molecules, and biological processes such as protein folding, protein-protein interactions and phosphorylation events. | 2010-07-01 |
20100168429 | Transition metal catalyzed synthesis of N-aminoindoles - The present invention relates to a process for the regioselective synthesis of compounds of the formula I, | 2010-07-01 |
20100168430 | MULTIKINASE INHIBITOR - It is intended to provide a compound represented by the formula (1): | 2010-07-01 |
20100168431 | NOVEL ISOQUINOLINIUM COMPOUNDS USEFUL IN THE PREPARATION OF CISATRACURIUM AND ASSOCIATED INTERMEDIATES - The present invention provides novel isoquinolinium compounds, methods of producing the isoquinolinium compounds, and methods for converting them into cisatracurium, e.g., cisatracurium besylate. The isoquinolinium compounds of the present invention can be obtained in the form of solids, which can be purified using simple techniques and can be used to afford pure cisatracurium besylate without HPLC purification | 2010-07-01 |
20100168432 | Process for the Preparation of Montelukast - The present invention relates to a process for the preparation of Montelukast or a salt thereof comprises, i) condensing Methyl-2-[3-[3-(2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-chloro propyljbenzoate obtained above with 1-(mercaptomethyl)cyclopropane acetic acid in presence of alkali carbonates such as Cesium Carbonate, followed by salification with organic amine ii) neutralizing the organic amine salt as obtained above with organic/inorganic acid followed by reaction with methylmagnesium chloride in the presence of Cerium Chloride followed by treatment with organic base yields montelukast amine salt iii) converting the montelukast amine salt to Montelukast Free acid iv) saltification of Montelukast free acid with Sodium hydroxide affords Montelukast Sodium. | 2010-07-01 |
20100168433 | PROCESS FOR PREPARING BEPOTASTINE AND INTERMEDIATES USED THEREIN - A process for stereospecific preparation of bepotastine of formula (I) and novel intermediates used therein having formulae (II) to (IV) are provided. The inventive process comprises subjecting (RS)-4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine to a reaction with a 4-halobutanoic acid l-menthyl ester, halo being chloro, bromo or iodo, in an organic solvent in the presence of a base to produce (RS)-bepotastine l-menthyl ester of formula (II), conducting a reaction of the compound of formula (II) with N-benzyloxycarbonyl L-aspartic acid in an organic solvent to induce selective precipitation of bepotastine l-menthyl ester.N-benzyloxycarbonyl L-aspartate of formula (III), filtering the precipitates formed in step 2) to isolate the compound of formula (III), treating the compound of formula (III) with a base to liberate bepotastine l-menthyl ester of formula (IV), and hydrolyzing the compound of formula (IV) in the presence of a base. The inventive process can provide bepotastine having a high optical purity of not less than 99.5% in a high yield, and thus, is useful in the development of anti-histamines and anti-allergic agents. | 2010-07-01 |
20100168434 | INHIBITION OF POLYMERISATION - The present invention provides methods and compositions for inhibiting polymerisation of ethylenically unsaturated monomers, which involve the use of nitroxide compound of formula (I): | 2010-07-01 |
20100168435 | PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-5-(1-ALKYLTHIO)ALKYLPYRIDINES - 2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield. | 2010-07-01 |
20100168436 | PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-5-(1-ALKYLTHIO)ALKYLPYRIDINES - 2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield from a non-pyridine source by cyclization. | 2010-07-01 |
20100168437 | PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-5-(1-ALKYLTHIO)ALKYLPYRIDINES - 2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield by cyclization and thioalkylation. | 2010-07-01 |
20100168438 | DUAL FUNCTION UV-ABSORBERS FOR OPHTHALMIC LENS MATERIALS - Disclosed are UV absorbers that contain a labile functional group capable of initiating free radical polymerization. | 2010-07-01 |
20100168439 | SELF-ASSEMBLED POLYHEDRA - Self-assembling multimeric physical models of closed polyhedral structures made of structurally symmetric units, and which mimic the structure and self-assembly characteristics of naturally occurring systems such as viral capsids, are provided. Also provided are methods of creating structurally symmetric units, kits for forming self-assembling physical models of polyhedral structures, and methods of forming the same. | 2010-07-01 |
20100168440 | Homogeneous Asymmetric Hydrogenation Process - Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity. | 2010-07-01 |
20100168441 | PROCESS FOR PRODUCTION OF SUBSTITUTED BENZENE - Disclosed is a process for production of a substituted benzene, which comprises intramolecularly and/or intermolecularly trimerizing a triple bond in an alkyne in the presence of a transition metal catalyst to yield a substituted benzene compound. In the process, the transition metal catalyst is prepared from an iminomethylpyridine represented by the formula (1) or (2), a transition metal salt or a hydrate thereof, and a reducing agent in a reaction system and is used to perform the trimerization. The process can be used in any one of the intramolecular cyclization of a triyne compound, the cyclization of a diyne compound or an alkyne compound and the intermolecular cyclization of three molecules of an alkyne compound, is excellent in economic effectiveness and operability, and is practically advantageous. | 2010-07-01 |
20100168442 | PENTAARYLDIAMINE-CONTAINING BISMALEIMIDE COMPOUND AND PRODUCING METHOD THEREOF - A pentaaryldiamine-containing bismaleimide compound of Formula (I): | 2010-07-01 |
20100168443 | Ethoid-Containing Compounds, Methods for Preparing Ethoid-Containing Compounds, and Methods of Use - Ethoid-containing compounds comprising one or more ethoid moieties (e.g., a methyleneoxy, Ψ[CH | 2010-07-01 |
20100168444 | DIINDENOTHIOPHENE DERIVATIVES AND USE THEREOF - A diindenothiophene derivative of the following formula (1) is disclosed: | 2010-07-01 |
20100168445 | PROCESS FOR PREPARING EPSILON-CAPROLACTONE - The present invention provides a process for preparing ε-caprolactone in a purity above 99%, in which 6-hydroxycaproic ester comprising from 0.5 to 40% by weight of adipic diester is cyclized in the gas phase at from 150 to 450° C. in the presence of oxidic catalysts and ε-caprolactone is obtained from the cyclization product by distillation. | 2010-07-01 |
20100168446 | METHOD FOR PURIFICATION OF CYCLIC ESTER - A method of purifying a cyclic ester, comprising: mixing a co-distillated liquid comprising a cyclic ester produced by heating depolymerization of a hydroxycarboxylic acid oligomer in the presence of a depolymerization solvent and the depolymerization solvent with an organic solvent for washing which is mutually soluble with the depolymerization solvent and has a lower boiling point than the cyclic ester; subjecting the resultant mixture liquid to liquid-liquid separation into an organic solvent phase containing the depolymerization solvent and a cyclic ester phase containing the organic solvent; and then evaporating the organic solvent from the cyclic ester phase containing the organic solvent to recover the cyclic ester containing a reduced amount of the depolymerization solvent. As a result, purified cyclic ester is recovered at high heat efficiency, purification efficiency and operation efficiency, from the co-distillate liquid containing the depolymerization solvent and the cyclic ester from the depolymerization system for thermal decomposition of the hydroxycarboxylic acid oligomer in the presence of the depolymerization solvent. | 2010-07-01 |
20100168447 | PRODUCTION OF DIHYDRONEPETALACTONE - This invention provides a process for producing dihydronepetalactone using mixtures comprising both trans-cis nepetalactone and cis-trans nepetalactone. A reaction mixture comprising trans-cis nepetalactone and cis-trans nepetalactone is first contacted with hydrogen in the presence of at least one hydrogenation catalyst under conditions that optimise the preferential conversion of trans-cis nepetalactone to dihydronepetalactone. Cis-trans nepetalactone is subsequently converted to dihydronepetalactone by contact with hydrogen in the presence of at least one hydrogenation catalyst. | 2010-07-01 |
20100168448 | Methods of Preparing Cannabinoids From Plant Material - The invention relates to methods of preparing cannabinoids in substantially pure form starting from plant material. Also described are substantially pure preparations of various cannabinoids and cannabinoid acids, and also extracts enriched in cannabinoids and cannabinoid acids. | 2010-07-01 |
20100168449 | Spray dried zeolite catalyst - An attrition-resistant catalyst is prepared contacting a spray dried zeolite with a modifying agent. The modifying agent is (i) a halogen-free compound hydrolyzable to an oxide selected from the group consisting of silica, alumina, titania, zirconia, niobia, and mixtures thereof; or (ii) a sol selected from the group consisting of silica, alumina, titania, zirconia, niobia, and mixtures thereof. | 2010-07-01 |
20100168450 | NOVEL BRANCHED ALKOXYLATES - Novel alkylene oxide-extended alkoxylates of a branched 1,3-dialkyl-oxy-2-propanol may be prepared by a convenient process comprising adding epichlorohydrin to a stoichiometric excess of a branched alcohol, wherein the molar ratio of branched alcohol:epichlorohydrin is at least about 3:1, preferably in the presence of a Group 1 A metal hydroxide and a phase transfer catalyst, followed by alkoxylation in the presence of an ionic catalyst. The branched alkyl chain may be saturated or unsaturated and may contain one or more heteroatoms. The repeating alkoxy units from the alkylene oxide are in the 2-position. The compositions are useful as surfactants, diluents, and the like, and may be less expensive than other branched surfactants. | 2010-07-01 |
20100168451 | PREPARATIVE METHOD OF DIHYDROCUCURBITACIN F-25-O-ACETATE AND THE USE THEREOF IN THE MANUFACTURE OF MEDICAMENTS FOR TREATING CANCERS - A method for producing dihydrocucurbitacin F-25-0-acetate consisting of the steps as followed: percolating radix hemsleyae using acetone as solvents to obtain extract; eluting the extract in silica gel column using chloroform: methanol as eluting agent (gradient) to obtain the crude; recrystallizating the crude using methanol or ethanol to obtain di-hydrocucurbitacin F-25-O-acetate (purity:>98%). And the use of dihydrocucurbitacin F-25-O-acetate in the manufacture of medicaments for treating cancers of liver, lung, stomach, larynx, prostate and leukemia. | 2010-07-01 |
20100168452 | High Oleic Imidazolinone Resistant Sunflower - A sunflower seed having imidazolinone resistance and an oleic acid content of greater than 85 percent is provided. Sunflower cultivars designated E83329, OI 1601 A, OI2653R, and OI 1601 B and having high oleic acid and imidazolinone resistance, plants and seeds of the E83329, OI1601A, OI2653R, and OI 1601 B sunflower cultivars, methods for producing a sunflower plant produced by crossing the E83329, OI 1601 A, OI2653R, or OI 1601 B cultivar with itself or with another sunflower plant, and hybrid sunflower seeds and plants produced by crossing the E83329, OI 1601 A, OI2653R, or OI 1601 B cultivar with another sunflower line or plant are also provided. | 2010-07-01 |
20100168453 | METHOD FOR THE SYNTHESIS OF OMEGA-AMINO-ALKANOIC ACIDS - The invention relates to a method for the synthesis of amino acids/esters of general formula NH | 2010-07-01 |
20100168454 | CATALYTIC HYDROGENATION - Catalytic hydrogenation of a double bond, notably a C═C or C═N double bond, is carried out using a homogenous catalyst which is a complex of rhodium or other transition metal containing at least one ligand which is a nitrogenous organic base. Preferably the complex is phosphorus-free and the ligand is a bicyclic base having formula | 2010-07-01 |
20100168455 | Production of Hydroxylated Fatty Acids in Genetically Modified Plants - This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants. In addition, the use of genes encoding fatty acid hydroxylases or desaturases to alter the level of lipid fatty acid unsaturation in transgenic plants is described. | 2010-07-01 |
20100168456 | CHIRAL PHOSPHOROUS COMPOUNDS - The present invention provides P-chiral compounds of general formulae (II) and (III): in formula (II) at least one of R | 2010-07-01 |
20100168457 | MONOLITHIC ELECTROKINETIC PUMP FABRICATION - High-pressure electrokinetic (“EK”) pumps comprising a hybrid monolith provide a high surface charge density and a continuous stable skeleton morphology with micrometer- sized through-pores. The hybrid monolith of the subject invention has superior mechanical strength and better stability in comparison to prior art monoliths with equivalent mechanical stability. The surface charge of the hybrid monolith can be modified and/or made stable by the use of different chemical reagents. The chemical reagents and resulting modification to the monolith serves to expand the usefulness of the hybrid monolith to a variety of pumping applications including chip-based systems and other applications where the ability to pump an acidic solution is required. | 2010-07-01 |
20100168458 | PROCESS FOR CONVERTING SI-H COMPOUNDS TO SI-HALOGEN COMPOUNDS - Silicon compounds having Si—H groups are converted into silicon compounds having Si—X groups by reaction with HX in the gas phase in the presence of a quaternary ammonium or phosphonium halide catalyst or an ionic chloride of a heterocycle organically substituted on the heteroatom. | 2010-07-01 |
20100168459 | SYNTHESIS OF PHENOLIC ESTERS OF HYDROXYMETHYL PHENOLS - The present invention provides a process for the production of a compound of formula (I) or a salt thereof, wherein R is hydrogen, a straight, branched or cyclic C | 2010-07-01 |
20100168460 | PROCESS FOR THE PREPARATION OF (2R,3S)-3-PHENYLISOSERINE METHYL ESTER ACETATE SALT - A process for the enantioselective preparation of (2R,3S)-3-phenylisoserine methyl ester acetate salt of formula (I) which is an useful building block for the synthesis of taxane derivatives. The process involves the resolution of racemic threo-phenylisoserine amide and its conversion into (I). | 2010-07-01 |
20100168461 | Bio-Based Terephthalate Polyesters - Bio-based terephthalic acid (bio-TPA), bio-based dimethyl terephthalate (bio-DMT), and bio-based polyesters, which are produced from a biomass containing a terpene or terpenoid, such as limonene are described, as well as the process of making these products. The bio-based polyesters include poly(alkylene terephthalate)s such as bio-based poly(ethylene terephthalate) (bio-PET), bio-based poly(trimethylene terephthalate) (bio-PTT), bio-based poly(butylene terephthalate) (bio-PBT), and bio-based poly(cyclohexylene dimethyl terephthalate) (bio-PCT). | 2010-07-01 |
20100168462 | PROCESS FOR THE PREPARATION OF BETA-GAMMA ENE CARBONYL DERIVATIVES - The present invention relates to a preparation of β-γ ene carboxylic or ketone derivatives, which may also have particular requirement on the configuration of the carbon-carbon double bond. The method requires a thermal treatment of α-β unsaturated malonate or acetylacetonate derivatives in the presents of at least one carboxylic acid and at least one alkaline, alkaline-earth or lanthanide halide or carboxylates. | 2010-07-01 |
20100168463 | METHOD OF PRODUCING 6,6-DIMETHYL-3-OXABICYCLO[3.1.0]HEXAN-2-ONE - A method of producing 6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one comprising subjecting a cyclopropane compound of the formula (1): | 2010-07-01 |