23rd week of 2010 patent applcation highlights part 58 |
Patent application number | Title | Published |
20100144469 | TRAINING BAT WITH VISUAL FEEDBACK OF PROPER SWING - A training baseball bat has an internal movable magnet that accelerates to the end of the bat when swung at a fast enough speed. As the magnet moves it passes through a coil that is connected to one or more LEDs so that the LEDs momentarily flash as the magnet moves through the coil. An axially positionable stationary magnet can be used to hold the movable magnet until sufficient centrifugal force is imparted by the swing to overcome the magnetic holding force. | 2010-06-10 |
20100144484 | TORQUE PROPORTIONING DIFFERENTIAL - A differential gear mechanism including a gear case having a body defining a gear chamber having a pair of opposed openings with a pair of output gears rotatably supported in the gear chamber adjacent to the openings. At least one of the output gears has a hub with a tapered portion facing an adjacent opening. At least one of the openings includes an inner chamfer portion that corresponds to an adjacent tapered portion. The gear case and gear set cooperate to move the output gear such that the tapered portion is disposed in frictional, torque translating engagement with a chamfered portion to bias torque translated through the differential to the output shafts under predetermined conditions. | 2010-06-10 |
20100144486 | MULTI-SPEED TRANSMISSIONS - The transmission has a plurality of members that can be utilized in powertrains to provide at least nine forward speed ratios and one reverse speed ratio. The transmission includes four planetary gear sets, six torque-transmitting devices, and four fixed interconnections. The powertrain includes an engine and torque converter that is continuously connected to one of the planetary gear members and an output member that is continuously connected with another one of the planetary gear members. The six torque-transmitting devices provide interconnections between various gear members, and the transmission housing, and are operated in combinations of three to establish at least nine forward speed ratios and one reverse speed ratio. | 2010-06-10 |
20100144489 | DEVICE AND METHOD FOR TRANSMITTING ENGINE POWER - An engine power transmission device for improving the acceleration performance of an engine connected to a torque converter of construction machinery in accelerating from standstill, wherein a clutch ( | 2010-06-10 |
20100144490 | Resistance Garments And Active Materials - Resistance garments include for example a first cuff and a second cuff that circumscribe a portion of a wearer's body; an adjustment device fixedly attached to the first cuff; and a resistive element connecting the first cuff and the second cuff, and coupling with the adjustment device. An active material includes a backing fabric and one or more length-adjusting devices, that each include a first filament and a second filament that are interwoven with the backing fabric and substantially parallel with one another, and one or more motors. Each of the motors drives first and second spooling elements that alternatively reel in or reel out portions of the first and second filaments, respectively. The reeling in or out thereby adjusts (a) a length of the filaments, (b) a length of the length-adjusting device corresponding to the at least one motor, and (c) a length of the active material. | 2010-06-10 |
20100144501 | Articulating exercise harness system - An articulating exercise harness system includes a harness to secure a user's wrist and a handle that is selectively gripped by the user. A bracket is pivotally connected to the handle at a proximal end of the bracket. The harness is adjustably along the user's forearm relative to the position of bracket. A weight engagement member is rotatably connected to the bracket. The bracket is rotatable relative to the handle and the weight engagement member is rotatable relative to the bracket. Because the weight engagement member can rotate forward and backward on the bracket, relative to the handle, the invention can be used to both push and pull exercise weights or other loads. | 2010-06-10 |
20100144503 | Therapeutic Shoulder Apparatus - In one embodiment, a shoulder exercise and stretching apparatus includes a forearm support, a forearm securing means for securing a user's forearm to the forearm support, an elbow support to capture the elbow of a user and keep the user's arm in a desired position to isolate the user's shoulder as a pivot point for rotation, and a rotation member coupled to the forearm support to rotate the forearm support through a desired plane and thereby provide an angular force to a target shoulder of the user. One or more handles, may be provided for grasping by a user's free hand to assist in the movement of the rotation member. Measurement means may be provided for determining the rotation of the apparatus. Resistance means may be provided to provide for resistance exercises of the shoulder. | 2010-06-10 |
20100144505 | ROLLER USABLE WITH IMAGE FORMING APPARATUS AND METHOD OF MANUFACTURING THE SAME - A roller usable with an image forming apparatus includes a shaft, a body formed on an outer surface of the shaft, and a tube disposed on an outer surface of the body. The tube is formed so that opposite side end portions of the tube contact opposite side surfaces of the body. The opposite side end portions of the tube are heated and pressurized so as to be secured on the opposite side surfaces of the body. | 2010-06-10 |
20100144507 | PACKAGE HAVING RECLOSEABLE POUR SPOUT - A package having a recloseable pour spout is disclosed, with the package including front and rear package panels which may be joined at respective side edges thereof by inwardly extending side gussets. An upper edge portion of the package is removable, including one of the side gussets, to form a pour spout for dispensing the contents of the package. A fastener strip, which can be detachably connected to itself, extends between confronting inside surfaces of the front and rear package panels, adjacent to the pour spout, whereby the pour spout can be conveniently closed after the package is initially opened. The package can include a longitudinal seal which extends from adjacent the pour spout to overlap the fastener strip. When the package includes side gussets, the package may include an arrangement of corner seals, with the corner seals at the one of the gussets at which the package pour spout is formed not extending the full length of the package, thereby desirably facilitating shaping of the package to form the pour spout. A method of forming the present package is also disclosed. | 2010-06-10 |
20100144508 | METHOD AND DEVICE FOR CLEANING OF A FLUID IN A CENTRIFUGAL SEPARATOR - A method for purifying a fluid from contaminating particles in a centrifugal separator by means of a separation aid which is of higher density than the fluid and which binds said particles, the centrifugal separator having a rotor body that rotates about an axis of rotation. The fluid to be purified is led via an inlet into a separation chamber delimited by the rotor body. Separated particles are discharged via a first outlet and clarified fluid cleared is discharged via a second outlet. The fluid being mixed with an amount of separation aid, supplied to the separation chamber. The pollutant particles are bound to the separation aid, which is forced out by the rotation of the rotor body to the periphery thereof. A small flow of separation aid and particles bound thereto are discharged from the separation chamber via the first outlet, and a flow of purified fluid is discharged from the separation chamber via the second outlet. | 2010-06-10 |
20100144511 | MICROPOROUS CERAMICS AND METHODS OF MANUFACTURE - Inorganic microporous metal oxide materials, such as aluminum-based microporous ceramic materials, useful for loop heat pipes, insulators, thermal management devices, catalyst supports, substrates, and filters, among others. An example method of manufacture includes heating a mixture of alumina (Al | 2010-06-10 |
20100144512 | METHOD FOR PRODUCTION OF DDR TYPE ZEOLITE MEMBRANE - A method for producing a DDR type zeolite membrane, which method comprises a membrane formation step of immersing a porous substrate having a DDR type zeolite seed crystal adhered thereon, in a raw material solution containing 1-adamantaneamine, silica (SiO | 2010-06-10 |
20100144515 | FLUORINATED DIALKOXY-DIIMINO CATALYST COMPONENTS - This invention relates to the fluorinated dialkoxy-diimine metal complexes and their use in catalyst system for the polymerisation or oligomerisation of ethylene and alpha-olefins. | 2010-06-10 |
20100144517 | SEPARATION OF N,N,N'-TRIMETHYLBISAMINO- ETHYLETHER FROM MIXTURES COMPRISING TERTIARY AMINES OR TERTIARY AMINOALKYLETHERS - The present invention relates to a method for recovering N,N,N′-trimethylbisaminoethylether from a mixture with its amide and a method for separating N,N,N′-trimethylbisaminoethylether from mixtures comprising tertiary amines or tertiary aminoalkylether as well as a composition comprising a mixture of N,N,N′-trimethylbisaminoethylether and a transamidation agent. | 2010-06-10 |
20100144521 | Rocks and Aggregate, and Methods of Making and Using the Same - Compositions comprising synthetic rock, e.g., aggregate, and methods of producing and using them are provided. The rock, e.g., aggregate, contains CO | 2010-06-10 |
20100144523 | SYNERGISTICALLY ACTIVE HERBICIDAL AGENTS THAT ARE COMPATIBLE WITH CULTIVATED PLANTS AND CONTAIN HERBICIDES FROM THE GROUP OF BENZOYLPYRAZOLES - Herbicidal compositions comprising
| 2010-06-10 |
20100144524 | Systems and Methods for Applying Particle Films to Control Stress on Plant Tissues - Provided herein are systems and methods for applying particle films to control stress on plant tissues. An exemplary method for controlling stress on plant tissues includes calculating a current plant tissue stress value for the plant tissues, and applying an effective amount of a particle film to the plant tissues if the calculated current plant tissue stress value is greater than or equal to a predetermined plant tissue stress value. The method may further include calculating a second current plant tissue stress value for the plant tissues after the application of the effective amount of the particle film, and calculating a future plant tissue stress value for the plant tissues. The calculated current plant tissue stress value, the second current plant tissue stress value, and the future plant tissue stress value may be analyzed to predict a future application of the effective amount of the particle film to the plant tissues. | 2010-06-10 |
20100144526 | COMPOSITION FOR WEEDING - A mixed composition for weeding useful as a herbicide which is effective against a wide spectrum of weeds, is highly active, has excellent residual activity, and is highly safe for useful plants. It is characterized by containing as an active ingredient a combination of (A) a compound selected among a difluoromethanesulfonylanilide compound represented by the general formula (I): | 2010-06-10 |
20100144527 | DISPERSIONS COMPRISING HYDROXYPHENYLPYRUVATE DIOXYGENASE INHIBITORS - The present invention relates to dispersions comprising
| 2010-06-10 |
20100144529 | IDENTIFICATION OF A NEW CLASS OF EPSP SYNTHASES - Compositions and methods for conferring tolerance to glyphosate in bacteria, plants, plant cells, tissues and seeds are provided. Compositions include a novel class of EPSPS enzymes, designated Class III, and polynucleotides encoding such enzymes, vectors comprising those polynucleotides, and host cells comprising the vectors. The novel proteins comprise at least one sequence domain selected from the Class III domains provided herein. These sequence domains can be used to identify EPSP synthases with glyphosate resistance activity. | 2010-06-10 |
20100144531 | METHOD FOR ENHANCING INTRINSIC PRODUCTIVITY OF A PLANT - A method of increasing plant hormone activity in a plant comprising applying to the plant, part of the plant, the plant propagation material thereof and/or a surrounding area thereof an effective amount of one or more neonicotinoid compounds selected from thianicotinyl compounds and tetrahydrofuranyl compounds. | 2010-06-10 |
20100144532 | PROCESS FOR MANUFACTURE OF HIGH PURITY D-(-)-N,N-DIETHYL-2-(alpha-NAPHTHOXY) PROPIONAMIDE - According to one aspect of the present invention there is provided a substantially high purity D-(−)-N,N-diethyl-2-(α-naphthoxy)propionamide and a process for the manufacture of substantially higher purity D-(−)-N,N-diethyl-2-(α-naphthoxy)propionamide having chemical purity near about or above 95%, and chiral purity near about or more than 97%. According to another aspect of the invention is to provide an agrochemical compositions containing highly pure optically active D-(−)-N,N-diethyl-2-(α-naphthoxy)propionamide. | 2010-06-10 |
20100144533 | DELIVERY OF ETHYLENE BLOCKING AND/OR PROMOTING AGENTS - A composition including an ethylene blocking agent complex formed from the product of an ethylene blocking agent and a host, and at least one water-soluble polymer, wherein the ethylene blocking agent complex and the at least one water-soluble polymer are intermingled is disclosed. | 2010-06-10 |
20100144534 | Compositions and methods for the control of nematodes and soil borne diseases - The instant invention relates to compositions and methods for the control of nematodes and soil borne diseases using compositions comprising high terpene containing oils and one or more surfactants. The invention also relates to methods for increasing the wetted soil volume available for water utilization by plant roots using the disclosed compositions. | 2010-06-10 |
20100144538 | GENEMAP OF THE HUMAN GENES ASSOCIATED WITH SCHIZOPHRENIA - The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to SCHIZOPHRENIA disease and/or their response to a particular drug or drugs. | 2010-06-10 |
20100144581 | Aqueous Highly Acidic Hard Surface Cleaning Compositions - Provided are highly aqueous liquid acidic hard surface cleaning compositions having a pH of about 3 or less which comprise: an acid constituent, preferably comprising a ternary acid system consisting formic acid, sulfamic acid and oxalic acid, optionally at least one or more further co-acids; at least one nonionic surfactant based on monobranched alkoxylated C10/C11-fatty alcohols; an organic solvent constituent which comprises at least one glycol ether solvent, preferably a glycol ether solvent which desirably mitigates or masks malodors of the acid constituent, especially when the acid constituent comprises formic acid; optionally a cosurfactant constituent, including one or more nonionic, cationic, amphoteric or zwitterionic surfactants but preferably one or more nonionic surfactants and excluding cationic, amphoteric or zwitterionic surfactants; optionally one or more further constituents selected coloring agents, fragrances and fragrance solubilizers, viscosity modifying agents including one or more thickeners, pH adjusting agents and pH buffers including organic and inorganic salts, optical brighteners, opacifying agents, hydrotropes, abrasives, and preservatives, as well as other optional constituents known to the art; and the balance, water, wherein water comprises at least 80% wt. of the composition. | 2010-06-10 |
20100144583 | INCREASING SURFACE ACTIVE PROPERTIES OF SURFACTANTS - Surfactant-containing compositions are described which include a protein component that has the effect of improving the surface-active properties of the surfactants contained in the compositions. The surfactant-containing compositions having the protein component demonstrate significantly lower critical micelle concentrations (CMC) than do comparable compositions having no protein component. In addition, the surfactant-containing compositions having the protein component has the effect of converting greasy waste contaminants to surface active materials. | 2010-06-10 |
20100144584 | WATER-ACTIVATED "GREEN" CLEANING WIPE - Eco-friendly, or “green”, cleaning wipes are disclosed. The wipes may include a substrate and a green concentrated aqueous cleaning composition impregnated therein. The wipes are dry to the touch before they are activated by water and applied to inanimate surfaces for cleaning. Because of the green concentrated cleaning composition and water-activation just before application, the disclosed wipes may clean larger surface areas and have longer shelf lives and lower weights for easy transportation, packaging and handling than conventional wet wipes that are pre-loaded with a diluted cleaning composition. | 2010-06-10 |
20100144586 | SURFACTANT COMPOSITION - Disclosed is a surfactant composition containing an alkyl sulfate ester salt derivative represented by the following general formula (1). R—O—(PO) | 2010-06-10 |
20100144587 | Frequency modulated drug delivery (FMDD) - Embodiments of the present disclosure include a coordination complex, comprising a first biologically active moiety, a second biologically active moiety, and a metal, wherein the first biologically active moiety and second biologically active moiety are bound to the metal by covalent coordination bonds, and wherein the first biologically active moiety and second biologically active moiety are different. These complexes may enhance the pharmacodynamic properties of biologically active moieties. | 2010-06-10 |
20100144601 | Anti-TNF Alpha Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses - A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNFα including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. | 2010-06-10 |
20100144602 | Methods of Inhibiting Metastatic Cancer by Administration of Streptolysin O - The invention provides a method for administering streptolysin O for treatment of various conditions including connective tissue disorders, reproductive fibroses and conditions mediated by the CD44 receptor. The invention also provides methods for protecting nerve cells from the effects of neurotoxic agents by the administration of streptolysin O. | 2010-06-10 |
20100144605 | RESCUE OF GONADOTROPIN RELEASING HORMONE RECEPTOR MUTANTS - Herein disclosed is a method of rescuing gonadotropin-releasing hormone receptor (GnRHR) mutants with IN3 or a mimetic thereof. IN3 significantly rescues 11 missense mutations as assessed by radioligand binding and by IP production. Such rescue occurred despite widely disparate loci along the receptor. In addition, many altered GnRH receptors (terminally truncated, internal deletions, or lacking the ability to form bridges to form tertiary structure) were rescued with IN3. | 2010-06-10 |
20100144607 | ANTI-INFLAMMATORY AND ANTIALLERGIC CYCLIC PEPTIDES - The present invention refers to synthetic, cyclic peptides containing a sequence of 13 L-amino acids in their primary structure which present anti-inflammatory and antiallergic activities, useful for the treatment of acute or chronic inflammation and/or allergies, being particularly useful for the treatment of acute or chronic allergic asthma. The invention also describes a pharmaceutical composition containing said peptides, its use and a method to treat or prevent acute and/or chronic inflammatory and/or allergic disorders. | 2010-06-10 |
20100144611 | TREATMENT OF T-CELL MEDIATED DISEASES - The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions. | 2010-06-10 |
20100144612 | PHOSPHORYLATED PYRONE ANALOGS AND METHODS - The invention relates to phosphorylated polyphenols, phosphorylated flavonoids, and phosphorylated pyrone analogs. Methods and compositions for the modulation of side effects of substances using such phosphorylated compounds are described. Methods and compositions are described for the modulation of blood-tissue barrier (BTB) transporter activity to increase the efflux of drugs and other compounds out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide lowered side effects when phosphorylated pyrone analogs are coadministered with therapeutic agents. | 2010-06-10 |
20100144613 | Combined use of DPP-IV Inhibitors and Gastrin Compounds - The invention relates to compositions, conjugates, and methods for the prevention and/or treatment of a condition and/or disease comprising a therapeutically effective amount of a DPP-IV inhibitor and a gastrin compound. The combination of a DPP-IV inhibitor and a gastrin compound provides beneficial effects, in particular sustained beneficial effects, in the prevention and/or treatment of conditions and/or diseases for which either a DPP-IV inhibitor or a gastrin compound have been demonstrated to have a therapeutic effect, including but not limited to diabetes, hypertension, chronic heart failure, fluid retentive states, obesity, metabolic syndrome and related diseases and disorders. Combinations of a DPP-IV inhibitor and a gastrin compound can be selected to provide unexpectedly additive effects or synergistic effects. | 2010-06-10 |
20100144614 | ALTERING MEMORY BY AFFECTING STAUFEN FUNCTION - The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or STAUFEN function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating staufen-dependent protein expression. The present invention further provides methods for treating a defect in long term memory formation associated with a defect in STAUFEN and methods for treating a defect in performance of a hippocampal-dependent cognitive task associated with a defect in STAUFEN. | 2010-06-10 |
20100144615 | NUCLEOTIDE SEQUENCE ENCODING A MODULATOR OF NF-KB - The present invention relates to nucleotide sequences encoding a modulator of NF-κB, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-κB-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-κB, methods of detecting modulator of NF-κB using the antibodies, methods of treatment associated with NF-κB activation and to methods of identifying compounds which modulate the activity of the modulator of NF-κB. | 2010-06-10 |
20100144618 | Compositions containing an intestinal trefoil peptide and a mucoadhesive - The invention features compositions containing an intestinal trefoil peptide and a mucoadhesive excipient. Such compounds are useful, e.g., for the treatment or prevention of lesions. Compositions containing an intestinal trefoil peptide and a mucoadhesive excipient may be formulated in combination with one or more additional therapeutic agents. | 2010-06-10 |
20100144621 | Use of Exendins and Exendin Agonists and GLP-1 Receptor Agonists for Altering the Concentration of Fibrinogen - The present invention relates to altering the concentration of fibrinogen, specifically, for example, by decreasing fibrinogen concentration. The present invention also relates to methods for improving the cardiovascular risk profile of a subject by decreasing fibrinogen concentration. | 2010-06-10 |
20100144623 | C-Terminal Domain Truncation of mGluR1a By Calpain and Uses Thereof - A composition comprising a peptide or a peptidomimetic thereof that inhibits the C-terminal domain truncation of mGluR1α by calpain, wherein the peptide is 10-30 amino acids in length and contains a sequence that is at least 70% homologous to VIKPLTKSYQGSGK. Also disclosed are methods of detecting the C-terminal domain truncation of mGluR1α by calpain, methods of inhibiting the C-terminal domain truncation of mGluR1α in a neuron, and methods of identifying a compound that inhibits the C-terminal domain truncation of mGluR1α. | 2010-06-10 |
20100144625 | Organic Compounds - A powder formulation for inhalation comprising a macromolecule and a crystalline carrier material. | 2010-06-10 |
20100144626 | Treatment of Multi-Drug Resistant Bacterial Infections - There is described an imidazole for the treatment of an infection caused or contributed to by microorganisms resistant to antibiotics. There is also described a method of treating a patient suffering from an infection caused or contributed to by microorganisms resistant to antibiotics, said method comprising the step of administering an effective amount of an imidazole. | 2010-06-10 |
20100144627 | METHODS FOR MODULATING SET AND USES THEREOF - The present invention provides methods for modulating SET activity by contacting SET with a binding agent such as an ApoE peptide derivative. In one embodiment of the invention, a pharmaceutical composition capable of modulating SET activity is administered to a patient for the treatment of an inflammatory or neurological condition. In another embodiment of the invention, compounds efficacious for the treatment of inflammatory and neurological conditions are identified by screening for a binding agent capable of competing with or inhibiting the binding of an ApoE derivative to SET. | 2010-06-10 |
20100144630 | Compositions, methods and uses for inhibition and/or treatment of influenza infection - Embodiments of the present invention illustrate methods and compositions for treating medical disorders. In certain embodiments, compositions and methods relate to reducing or inhibiting onset, transmission or development of a viral disorder. | 2010-06-10 |
20100144661 | SODIUM CHANNEL BLOCKERS - The present invention relates to sodium channel blockers. The present invention also relates to a variety of methods of treatment using the sodium channel blockers. | 2010-06-10 |
20100144663 | 2, 6-Dinitrogen-Containing Substituted Purine Derivatives, The Preparation And Uses Thereof - The present invention provides 2,6-dinitrogen-containing substituted purine compounds of formula (A) or salts or solvates thereof or the solvates of salts thereof, as well as pharmaceutical compositions containing such compounds. The compounds of the present invention have the characteristics of lower toxicity, broad anticancer spectrum, higher anticancer activity, good stability and the like. The compounds are useful for the manufacture of an antitumor medicament. The present invention also provides a process for preparing these compounds. | 2010-06-10 |
20100144668 | SEMI-FLUID FOOD PRODUCT INCLUDING BETA GLUCANE FIBRES AND GUAR GUM, AND USE THEREOF AS A FUNCTIONAL FOOD PRODUCT - The invention relates to a semi-fluid food product containing from 2.5 to 16 g of guar gum and from 2.8 to 11.3 g of beta-glucane fibres per portion of said food product, said portions ranging from 125 to 250 g, characterised in that the guar gum: beta-glucane fibres mass ratio ranges from 2:1 to 4:1. | 2010-06-10 |
20100144669 | DISSOLUTION AND PROCESSING OF CELLULOSE - The invention relates to a method for dissolving the components of gel forming materials suitable for use in wound care comprising the steps of admixing said components with an ionic liquid. The ionic liquid may be selected from the group of tertiary amine N-oxides, N,N-dimethyl formamide/nitrogen tetroxide mixtures, dimethyl sulphoxide/paraformaldehyde mixtures and solutions of limium chloride in N,N-dimethyl acetamide or N-methylpyrrolidone. | 2010-06-10 |
20100144693 | METHOD OF TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) - The present invention relates generally to the field of treatment and prophylaxis of retinal degenerative diseases. More particularly, the present invention contemplates a method for preventing, reducing the risk of development of, or otherwise treating or ameliorating the symptoms of, age-related macular degeneration (AMD) or related retinal conditions in mammals and in particular humans. The present invention further provides therapeutic compositions enabling dose-dependent or dose-specific administration of agents useful in the treatment and prophylaxis of age-related macular degeneration or related retinal degenerative conditions. | 2010-06-10 |
20100144695 | 4-AZETIDINYL-1-HETEROARYL-CYCLOHEXANOL ANTAGONISTS OF CCR2 - The present invention comprises compounds of Formula (I). | 2010-06-10 |
20100144697 | Stabilized pharmaceutical compositions containing a calcium channel blocker - The present invention provides a pharmaceutical composition containing a calcium channel blocker of the following formula or a pharmacologically acceptable salt thereof and a pharmacologically acceptable alkaline material which is added to an extent such that an aqueous solution or dispersion solution of said pharmaceutical composition containing a calcium channel blocker has a pH of at least 8: | 2010-06-10 |
20100144698 | SUBSTITUTED AZETIDINONES - Compounds are provided which have the structure | 2010-06-10 |
20100144699 | Combination Medicaments for Treating Bacterial Infections - Use of a monobactam antibiotic of formula (I) | 2010-06-10 |
20100144700 | HETEROCYCLIC-CARBONYL-DIAZABICYCLOALKANES AS MODULATORS OF THE NEURONAL NICOTINIC ACETYLCHOLINE ALPHA 4 BETA 2, SUBTYPE RECEPTOR FOR THE TREATMENT OF CNS RELATED DISORDERS - A compound of Formula 1: A-C(O)-Cy, wherein A is a diazabicyclic core, containing 7, 8, or 9 ring atoms, and selected from the following: 2,6-diazabicyclo[3.2.0]heptane; 3,6-diazabicyclo[3.ZO]heptane; 2,7-diazabicyclo[4.2.0]octane; 3,7-diazabicyclo[4.2.0]octane; 3,8-diazabicyclo[4.2.0]octane; 2,7-diazabicyclo[3.3.0]octane; 2,7-diazbicyclo[4.3.0]nonane; 2,8-diazbicyclo[4.3.0]nonane; 3,7-diazabicyclo[4.3.0]nonane; 3,8-diazabicyclo[4.3.0]nonane; 3,9-diazabicyclo[4.3.0]nonane; 2,6-diazabicyclo[3.2.1]octane; 3,6-diazabicyclo[3.2.1]octane; wherein the diazabicycle is attached as a radical to the depicted carbonyl via either one of the two ring nitrogen atoms, such that the carbonyl forms an amide bond with the ring nitrogen; Cy is a heteroaryl group; The compounds exhibit selectivity for, and bind with high affinity to, neuronal nicotinic receptors of the α402 subtype in the central nervous system (CNS). The compounds and compositions can be used to treat and/or prevent a wide variety of conditions or disorders, particularly CNS disorders. The compounds are believed to: (i) alter the number of nicotinic cholinergic receptors of the brain of the patient, (ii) exhibit neuroprotective effects, and (iii) when employed in effective amounts, not result in appreciable adverse side effects, namely side effects such as significant Increases in blood pressure and heart rate, significant negative effects upon the gastrointestinal tract, and significant effects upon skeletal muscle. | 2010-06-10 |
20100144701 | Modulators of CB1 Receptors - Compounds of formula (I) suppress the normal signalling activity CB1 receptors, and are thus useful in the treatment of diseases or conditions which are mediated by CB1 receptor signalling activity, such as treatment of obesity and overweight, prevention of weigh gain, treatment of diseases and conditions directly or indirectly associated with obesity and overweight: wherein A | 2010-06-10 |
20100144705 | EGFR KINASE KNOCKDOWN VIA ELECTROPHILICALLY ENHANCED INHIBITORS - Provided herein are electrophilically enhanced kinase inhibitors. Also provided herein are methods of making and utilizing the same. | 2010-06-10 |
20100144706 | Compounds - The present invention encompasses compounds of general formula (1) wherein R | 2010-06-10 |
20100144709 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO-DEGENERATIVE DISEASES - The invention provides novel 1,2,4-thiadiazole derivatives useful for preventing or treating an α-synucleopathy such as Parkinson's disease, as well as pharmaceutical compositions including them as biologically active ingredients, and methods for manufacturing them. | 2010-06-10 |
20100144710 | Piperazine and Piperidine MGLUR5 Potentiators - Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof, wherein A, B, D, Ar1, Ar2, R2, R3, R4, a, m and n are defined in the specification, methods for the use thereof, processes for making and pharmaceutical compositions containing the same. | 2010-06-10 |
20100144713 | 6-AND 7-AMINO ISOQUINOLINE COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME - 6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and 7-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided. | 2010-06-10 |
20100144714 | DERIVATIVES OF IMIDAZO PYRIMIDO AND DIAZEPINE PYRIMIDINE-DIONE, AND USE THEREOF AS A DRUG - The present invention relates to new derivatives of imidazo, pyrimido and diazepine-pyrimidine-dione of the general formula (I) in which R | 2010-06-10 |
20100144716 | New CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions - The present invention relates to the CGRP-antagonists of general formula I | 2010-06-10 |
20100144717 | 2-QUINOLINONE AND 2-QUINOXALINONE-DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS - The present invention relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, to their use in the treatment of bacterial infections, and to their methods of preparation. | 2010-06-10 |
20100144719 | PHARMACEUTICAL SUSPENSION - The present invention is directed to the provision of a pharmaceutical suspension. The suspension includes high molecular weight polyethylene glycol as a suspending agent. The suspension also typically includes an antimicrobial agent (e.g., polymeric quaternary ammonium compound), an antimicrobial system (e.g., borate/polyol complex system) or both. The suspension has been found particularly useful as an ophthalmic suspension, but can be used in other instances as well. | 2010-06-10 |
20100144722 | NOVEL HETEROCYCLIC COMPOUNDS AS GATA MODULATORS - Novel heterocyclic compounds, sstereoisomers thereof and/or pharmaceutically acceptable salts of formula (I) and its stereoisomers are provided. Additionally, methods of forming novel heterocyclic compounds, stereoisomers thereof and/or pharmaceutically acceptable salts of formula (I) and its stereoisomers are provided. | 2010-06-10 |
20100144725 | PESTICIDAL COMBINATIONS - A method of controlling or preventing pathogenic damage and/or pest damage in a plant propagation material, a plant, part of a plant and/or plant organ that grow at a later point in time, which comprises applying on the plant, part of the plant, plant organ, plant propagation material or a surrounding area thereof a combination comprising (I) one or more of a defined strobilurin compound selected from azoxystrobin, trifloxystrobin and fluoxastrobin, (II) one or more of a defined DMI: triazole compound selected from difenoconazole, prothioconazole, tebuconazole and triticonazole, and (III) one or more further defined fungicide selected fludioxonil, thiabendazole and ipconazole, in any desired sequence or simultaneously, provided the combination does not consist essentially of azoxystrobin, tebuconazole and fludioxonil. | 2010-06-10 |
20100144727 | Oxazolidine and Morpholine Carboxamide Derivatives as P2X7 Modulators - The present invention relates to a compound of formula (I): | 2010-06-10 |
20100144730 | PYRIDINONYL PDK1 INHIBITORS - The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same. | 2010-06-10 |
20100144762 | NOVEL SULFONAMIDES AS L-CPT1 INHIBITORS - The invention is concerned with novel sulfonamide derivatives of formula (I) | 2010-06-10 |
20100144763 | Pharmaceutical composition for inhibiting topoisomerase I and method for exploiting drug - The invention relates to the compounds isolated from | 2010-06-10 |
20100144764 | PYRIMIDINEDIONE DERIVATIVES AND METHODS OF USE THEREOF - The present invention relates to Pyrimidinedione Derivatives, compositions comprising a Pyrimidinedione Derivative and methods for using the Pyrimidinedione Derivatives for treating or preventing a metabolic disorder, dyslipidemia, a cardiovascular disease, a neurological disorder, a hematological disease, cancer, inflammation, a respiratory disease, a gastroenterological disease, diabetes, a diabetic complication, obesity, an obesity-related disorder or non-alcoholic fatty liver disease. | 2010-06-10 |
20100144767 | Use of sodium channel blockers for the treatment of visceral pain or pain caused by cancer treatment - The invention provides methods for treating visceral pain and pain associated with therapy. The compounds useful in the methods of the invention are blockers of sodium ion channels, and in particular compounds that bind to the SS1 or SS2 extracellular mouth of the α-subunit thereof. Particularly useful compounds are saxitoxin and its derivatives and analogues and tetrodotoxin and its derivatives and analogues. | 2010-06-10 |
20100144770 | Pyrimidinones as Casein Kinase II (CK2) Modulators - A compound having Formula I: or a pharmaceutically acceptable salt thereof, wherein X, R, R and R are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof. The compounds of Formula I are inhibitors of Casein kinase II (CK2) pathways. | 2010-06-10 |
20100144772 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION - Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase activator. Processes of their preparation are also described in the disclosure. The disclosure also describes method to characterize partial glucokinase activators. | 2010-06-10 |
20100144773 | PHARMACEUTICAL COMPOSITIONS FOR INTRANASAL ADMINISTRATION COMPRISING CHOLINE SALTS OF SUCCINIC ACID - The present invention relates to pharmaceutical compositions for the intranasal administration comprising a therapeutically effective amount of a compound of formula (I) or pharmaceutically acceptable salts thereof. Preferably, the pharmaceutically acceptable salt is selected from the group consisting of choline salt, sodium salt, potassium salt, and thiamine salt. Further, the present invention relates to methods for intranasal delivering compound of formula (I) and pharmaceutically acceptable salts thereof. Further, the present invention relates to methods for treating a neurodegenerative disease with using compositions of the present invention. | 2010-06-10 |
20100144774 | HETEROCYCLIC SPIRO-COMPOUNDS - The patent application relates to new heterocyclic compounds of the general formula (I), in which R, R | 2010-06-10 |
20100144776 | USE OF SNPS FOR THE DIAGNOSIS OF A PAIN PROTECTIVE HAPLOTYPE IN THE GTP CYCLOHYDROLASE 1 GENE (GCH1) - The present invention relates to an in vitro method for diagnosing a genetic predisposition or susceptibility for pain in a mammal which comprises detecting of at least one particular single nucleotide polymorphism (SNP) in a sample obtained from said mammal in the genomic locus-derived nucleic acid or fragment thereof of the locus GCH1. | 2010-06-10 |
20100144791 | CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING OBESITY - The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, and/or cardiometabolic disorders. | 2010-06-10 |
20100144793 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS - The present invention relates to compounds of the general formula (I) wherein (formula 2) independently represents a single bond or a double bond, represents a linking group A and A′ are each independently a 5- to 7-membered heterocyclic ring, wherein the heterocyclic rings A und A′ are optionally substituted by one or more substituents, selected from C | 2010-06-10 |
20100144794 | INSECTICIDAL N-SUBSTITUTED (6-HALOOALKYLPYRIDIN-3-YL)-ALKYL SULFOXIMINES - N-Substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines are effective at controlling insects. | 2010-06-10 |
20100144796 | NEW POLYMORPHS OF ETHYL 3-[(2-{[4-(HEXYLOXYCARBONYLAMINO-IMINO- METHYL)-PHENYLAMINO]-METHYL-1-METHYL-1H-BENZIMIDAZOLE-5-CARBONYL) -PYRIDIN-2-YL-AMINO]-PROPIONATE - The invention relates to new polymorphs of the active substance ethyl 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionate, the preparation thereof and the use thereof as pharmaceutical compositions. | 2010-06-10 |
20100144797 | ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PEST CONTROL AGENT - Novel pest control agents, particularly insecticides or miticides are provided. Isoxazoline-substituted benzamide compounds of General Formula (1) or a salt thereof: | 2010-06-10 |
20100144798 | Modulators of ATP-Binding Cassette Transporters - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 2010-06-10 |
20100144799 | OPTICAL ENANTIOMERS OF PHENYRAMIDOL AND PROCESS FOR CHIRAL SYNTHESIS - The present invention discloses optically pure (R) and (S) Phenyramidol enantiomers and their pharmaceutically acceptable salts, a process for synthesizing such enantiomers by means of a styrene oxide based synthesis, and also a clinical evaluation of (R) and (S) enantiomers of Phenyramidol, their salts and compositions thereof for enhanced/newer therapeutic benefits. | 2010-06-10 |
20100144812 | Heterocyclic Sulfonamide Inhibitors of Beta Amyloid Production Containing an Azole - Compounds useful for lowering beta amyloid levels are provided. The compounds have the structure of formula Ia: | 2010-06-10 |
20100144815 | AMINO ACID COMPOSITION - An amino acid composition is provided that can promote fat burning, improve endurance, and reduce fatigue during, for example, marathons, and that can lessen obesity and increase stress resistance. | 2010-06-10 |
20100144816 | FUNCTIONALLY SELECTIVE ALPHA2C ADRENORECEPTOR AGONISTS - In its many embodiments, the present invention provides a novel class of naphthene- and indane-type as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions. | 2010-06-10 |
20100144817 | FUNGICIDEL N-CYCLOALKYL-BENZYL-THIOCARBOXAMIDES OR N-CYCLOALKYL-BENZYL-N'-SUBSTITUTED-AMIDINE DERIVATIVES - The present invention relates to N-cycloalkyl-benzyl-thiocarboxamide or N-cycloalkyl-benzyl-N-substituted-carboximidamide amide derivatives of formula (I) wherein A represents a carbo-linked, unsaturated or partially saturated, 5-membered heterocyclyl; T represents S, N—R | 2010-06-10 |
20100144819 | Synergistic Methods for Control of Pests - The present invention provides a method for the synergistic control of insect pests, such as cockroaches and spiders, which comprises applying to a locus where insect pest control is needed or expected to be needed a synergistically effective amount of a combination of bifenthrin and fipronil. | 2010-06-10 |
20100144831 | BLOCKING OF GENE EXPRESSION IN EUKARYOTIC CELLS - The present invention provides methods for designing a sequence for efficient short interference RNA molecules. In particular, the present invention defines a universal target for siRNA derived from a poly A sequence, optionally in conjunction with unique sequences for gene silencing and inhibition of viral replication in a eukaryotic host cell. The present invention further provides methods for the treatment and prevention of diseases and disorders by silencing a gene of a virus, an oncogene, genes encoding transcription factors and many other diseases related genes. The present invention describes antisense nucleic acids compositions comprising sequences complementary to a target nucleic acid. The antisense sequences are designed to hybridize to complementary nucleic acid target regions in a target RNA, and inhibit translation, processing, transport, or binding by proteins or riboproteins. Target regions include, and are limited to a poly-A tail, and exclude, AUG, 5′ non-translated sequences, translation initiation factor binding sites, ribosome subunit binding sites, Shine Dalgarno sequence, 3′ nontranslated sequences, poly-addition site, 3′ cleavage site, coding region, intron, intron branch site, intron/exon junction, and splice sequence. | 2010-06-10 |
20100144832 | Prostate Cancer-Specific Alternations in ERG Gene Expression and Detection and Treatment Methods Based on Those Alterations - The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The disclosure further provides therapeutic compositions and methods of detecting, diagnosing, prognosing, and treating prostate cancer, including biomarkers for detecting the expression of two or more of the following genes: PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG. | 2010-06-10 |
20100144834 | METHODS FOR TREATING HYPERCHOLESTEROLEMIA - Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating hypercholesterolemia, or alternatively for treating or preventing atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides. | 2010-06-10 |
20100144837 | DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS - The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH. | 2010-06-10 |
20100144838 | Methods for Identifying Modulators of Pyrimidine Tract Binding Protein - Provided herein are methods and materials for identifying compounds that modulate polypyrimidine tract binding protein (PTB), a protein that functions as a negative regulator of pre-mRNA splicing by blocking the inclusion of numerous alternative exons into mRNA. | 2010-06-10 |
20100144862 | USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME - The invention relates to the use of substituted pyranone acid derivatives and of their physiologically acceptable salts for producing medicaments for treating the metabolic syndrome. | 2010-06-10 |
20100144864 | SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS - Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising one or more sGC modulators alone or in combination with one or more lipid altering agents and/or PDE inhibitors. | 2010-06-10 |
20100144865 | COMPOUND FEED FOR AQUACULTURE - The present invention relates to a fish feed comprising dioxabicyclo[3.3.0]octane derivates, in particular selected sesame lignans, and a vegetable oil or oil mixture comprising at least one 18-carbon chain omega-3 fatty acid. The dioxabicyclo[3.3.0]octane derivate will induce a desaturation and elongation of the 18-carbon chain fatty acid in the fish muscle into longer carbon chain polyunsaturated fatty acids. | 2010-06-10 |
20100144867 | USE OF LECITHIN:RETINOL ACYL TRANSFERASE GENE PROMOTER METHYLATION IN EVALUATING THE CANCER STATE OF SUBJECT - The present invention relates to a method of evaluating the cancer state of a subject using lecithin:retinol acyl transferase (LRAT) gene promoter methylation status. Methods of analyzing and quantifying LRAT gene promoter methylation level are also disclosed. The present invention also relates to methods of determining the prognosis for s subject having cancer by assessing LRAT mRNA expression and LRAT protein expression. Methods of cancer detection, diagnosis, prognosis, and treatment are also disclosed. | 2010-06-10 |