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22nd week of 2012 patent applcation highlights part 37
Patent application numberTitlePublished
20120135320MANUFACTURING METHOD OF CATHODE ELECTRODE FOR FUEL CELLS AND CATHODE ELECTRODE FOR FUEL CELLS - A manufacturing method for a cathode electrode including: (1) mixing a polymerizable electrolyte precursor having an alkylsulfonic acid group and a group represented by (R2012-05-31
20120135321BOILER UNIT - A boiler unit (2012-05-31
20120135322FUEL CELL SYSTEM - A fuel cell system includes a fuel cell module, a water supply apparatus for supplying water to the fuel cell module, a water container for supplying the water to the water supply apparatus, a condenser for condensing water vapor in an exhaust gas discharged from the fuel cell module and supplying the condensed water to the water container. The water container has a supply port for supplying the water from the condenser to the water container, and a discharge port for sending the water to the water supply apparatus, and a water channel having a serpentine pattern as a passage of the water from the supply port to the discharge port. An ion exchanger section is provided in the water channel.2012-05-31
20120135323LOW-TEMPERATURE FUEL CELL HAVING AN INTEGRATED WATER MANAGEMENT SYSTEM FOR PASSIVELY DISCHARGING PRODUCT WATER - A low-temperature fuel cell having an integrated water management system for passive discharge of product water includes at least one membrane-electrode assembly having at least one anode-side and one cathode-side electrode and at least one membrane disposed between the electrodes, current collector structures disposed on the anode-side and cathode-side and distribution structures for fuel and oxidant disposed on the anode-side and cathode-side. The cathode-side distribution structure hereby has a capillary structure for transporting away the product water and also gas supply channels.2012-05-31
20120135324DEVICE FOR REMOVING GENERATED WATER - Generated water is quickly and surely removed from a generated water discharge face of equipment which discharges generated water. There are provided equipment 2012-05-31
20120135325HYDROGEN ENERGY SYSTEMS - Hydrogen energy systems for obtaining hydrogen gas from a solid storage medium using controlled laser beams. Also disclosed are systems for charging/recharging magnesium with hydrogen to obtain magnesium hydride. Other relatively safe systems assisting storage, transport and use (as in vehicles) of such solid storage mediums are disclosed.2012-05-31
20120135326BACK-UP FUEL CELL ELECTRIC GENERATOR COMPRISING A COMPACT MANIFOLD BODY, AND METHODS OF MANAGING THE OPERATION THEREOF - A fuel cell electric generator designed for back-up in the absence of network electricity supply. The generator comprises a fuel cell stack, means for supplying the stack with a first and a second reagent flow comprising, in turn, pressure reducing means, and a manifold body to communicate with the stack said first and second reagent flows and at least a flow of coolant fluid via a respective coolant loop. The manifold body comprises inside chambers for the mixing of said reagent flows with corresponding re-circulated product flows and a coolant fluid expansion chamber within which said pressure reducing means of said first and second reagent flows are positioned at least partially drowned by said coolant. Method for the start-up and shut-down of the generator, and a method for detecting the flooding of a fuel cell and a method for detecting the presence of gas leakages in the generator are also disclosed.2012-05-31
20120135327MONITORING THE OPERATIONAL STATE OF A FUEL CELL STACK - A technique is described herein for monitoring the operational state of a fuel cell stack by the detection of nonlinearity in such a manner that an external test signal for frequency response is generated and applied to the fuel cell stack during operation, the resulting signal output from the fuel cell stack is measured, and the harmonic content of the measured signal is analyzed, the method including: applying a multiple frequency test signal comprising at least two sinusoidal waves as the test signal for frequency response to the fuel cell stack; and analyzing the resulting current or voltage signal output from the fuel cell stack.2012-05-31
20120135328FUEL CELL - According to one embodiment, a fuel cell includes an electric-power generator, a fuel distribution mechanism, and a pump. The electric-power generator includes a membrane electrode assembly including an anode, a cathode, and an electrolytic membrane. The fuel distribution mechanism includes a container and a thin tube. The container includes a fuel discharge surface, and contains the electric-power generator inside. The thin tube is formed in the container in a manner that a fuel outlet and a fuel inlet communicate with each other. The pump is connected directly to the fuel inlet.2012-05-31
20120135329HYDROGEN FED POWER SYSTEM AND METHOD FOR GENERATING POWER - The present invention relates to a hydrogen fed power system comprising: a high-pressure hydrogen container (2012-05-31
20120135330Membrane-Electrode Assembly with integrated sealing material - The invention relates to a catalyst-coated ion-conducting membrane and a membrane-electrode assembly (MEA) for electrochemical devices, in particular for fuel cells. The catalyst-coated, ion-conducting membrane is provided with a sealing material which is applied in the edge region to one side of the membrane and has a thickness which corresponds to at least the total thickness of the catalyst-coated membrane. Owing to their simple, material-conserving construction, the catalyst-coated ion-conducting membranes and the membrane-electrode assemblies produced therefrom can be manufactured inexpensively. They are used in PEM fuel cells, direct methanol fuel cells (DMFCs), electrolysers and other electrochemical devices.2012-05-31
20120135331CATHODE - The present invention relates to a cathode composed of a perovskite-type or fluorite-type mixed metal oxide containing molybdenum, to a composite comprising the mixed metal oxide and to a solid oxide fuel cell comprising the cathode. The cathode mixed metal oxide has an empirical formula unit: EaTbMocOn wherein: T is one or more transition metal elements other than Mo; E is one or more metal elements selected from the group consisting of lanthanide metal elements, alkali metal elements, alkaline earth metal elements, Pb and Bi; and a, b, c, and n are non-zero numerals which may be the same or different for each element.2012-05-31
20120135332FUEL CELLS HAVING IMPROVED DURABILITY - A fuel cell or a fuel cell stack component comprises an active area and a non-active area. A peroxide decomposing metal compound or metal alloy is disposed in or on the non-active area of a fuel cell or a fuel cell component. The metal compound or alloy is capable of providing a peroxide decomposing metal species that can migrate from the non-active area to an active area of a fuel cell. A fuel cell or membrane electrode assembly having a peroxide decomposing metal compound or alloy disposed in its non-active area exhibits improved durability.2012-05-31
20120135333ORGANIC/INORGANIC COMPOSITE BLEND MEMBRANE COMPOSITIONS OF POLYELECTROLYE BLENDS WITH NANOPARTICLES - The invention relates to composite blend membranes formed from blends of one or more polyelectrolytes, and one or more types of nanoparticles. Preferably the blend also includes one or more fluoropolymers. The addition of the nanoparticles was found to enhance the conductivity and mechanical properties of the membranes.2012-05-31
20120135334PARTIAL FLOW CELL - A partial flow cell may include a cathode chamber, an anode chamber, and a separator arrangement sandwiched between the cathode and anode chambers. The separator arrangement may be configured to permit ionic flow between electroactive materials disposed within the cathode and anode chambers. One of the cathode and anode chambers may be configured to permit an electroactive material to flow through the chamber during operation. The other of the cathode and anode chambers may be configured to hold an electroactive material fixed within the chamber during operation.2012-05-31
20120135335Fuel Cartridge with Flexible Liner - A cartridge connectable to a fuel cell is disclosed. The cartridge comprises an outer casing and an inner flexible liner containing fuel for the fuel cell. The inner flexible liner may have an insert disposed inside the inner liner to facilitate the transport of fuel from the cartridge to the fuel cell. The insert minimizes the fuel that is trapped within the cartridge. The inner flexible liner can be used without the outer casing. The outer casing can be substantially rigid or flexible. The cartridge is also adaptable to receive byproducts from the fuel cell. The cartridge can also be pressurized to push fuel to the fuel cell. Unidirectional relief valves are also disclosed to prevent internal pressure in the cartridge from becoming too high or too low.2012-05-31
20120135336CONTACT ELEMENT FOR AN ELECTRICALLY CONDUCTIVE CONNECTION BETWEEN AN ANODE AND AN INTERCONNECTOR OF A HIGH-TEMPERATURE FUEL CELL - The invention relates to a contact element for an electrically conductive connection between an anode and an interconnector of a high-temperature fuel cell. It is the object of the invention to achieve a more reliable electrically conductive connection with long-term stability between an anode and the associated interconnector of a high-temperature fuel cell. The contact element in accordance with the invention is arranged between an anode and an interconnector of a high-temperature fuel cell. It is formed with two areal electrically conductive part elements. In this respect, one respective part element is in touching contact with the anode and the other part element is in touching contact with the respective interconnector. Openings are formed in the part elements and the part elements are formed from materials having mutually different coefficients of thermal expansion.2012-05-31
20120135337Non-Destructive Testing Methods for Fuel Cell Interconnect Manufacturing - Various embodiments provide methods for testing a fuel cell interconnect including the steps of providing a fuel cell interconnect and performing a non-destructive test on the fuel cell interconnect comprising at least one of detecting a magnetic response of the interconnect, calculating a volume by optically illuminating the interconnect, detecting an acoustic response of the interconnect, and detecting a thermal response of the interconnect.2012-05-31
20120135338HOLOGRAPHIC RECORDING MEDIUM WITH CONTROL OF PHOTOPOLYMERIZATION AND DARK REACTIONS - The present invention relates to a system, as well as articles and holographic recording medium comprising the system, where the system comprises: a polymerizable component comprising at least one photoactive polymerizable material; and a photoinitiator component comprising at least one photoinitiator for causing the polymerizable component to polymerize to thereby form a plurality of holographic gratings when activated by exposure to a photoinitiating light source; wherein when a portion of the polymerizable component has been polymerized to form at least one holographic grating, the unpolymerized portion of the polymerizable component is resistant to further polymerization when not exposed to the photoinitiating light source. The present invention also provides methods for forming at least one holographic grating in a holographic recording medium having such a photopolymerizable system.2012-05-31
20120135339REFLECTIVE EXTREME ULTRAVIOLET MASK AND METHOD OF MANUFACTURING THE SAME - A reflective extreme ultraviolet mask includes a mask substrate having an exposing region and a peripheral region, the mask substrate including a light-scattering portion in the peripheral region, a reflective layer on an upper surface of the mask substrate, the reflective layer having a first opening exposing the light-scattering portion, and an absorbing layer pattern on the reflective layer, the absorbing layer pattern having a second opening in fluid communication with the first opening.2012-05-31
20120135340PHOTOMASK AND FORMATION METHOD THEREOF - A method for forming a photomask includes detecting a defect of the photomask which has a mirror layer formed on a first surface of a substrate, and forming a recess groove on a first layer which is formed on a second surface of the substrate, wherein the coordinate of the recess groove corresponds to the coordinate of the defect.2012-05-31
20120135341METHOD FOR DOUBLE PATTERNING LITHOGRAPHY AND PHOTOMASK LAYOUT - A method for double patterning lithography which is applied to a semiconductor substrate to form a plurality of trenches, includes a pattern formation process. In the pattern formation process, a plurality of predetermined patterns corresponding to the trenches are formed by using a graphic data system. A first pattern file and second pattern file are respectively formed. The first pattern file and the second pattern file respectively include a plurality of first patterns and a plurality of second patterns. The first patterns and the second patterns are intersected with each other to define a plurality of overlapped regions corresponding to the predetermined patterns. At least one of the first pattern file and the second file includes a plurality of dummy patterns therebeside. A photomask layout for double patterning lithography is also provided.2012-05-31
20120135342FIXING SOLUTION, FIXING METHOD, FIXING DEVICE, IMAGE FORMING METHOD AND IMAGE FORMING APPARATUS - To provide a fixing solution for fixing fine resin particles to a recording medium, the fixing solution including: a diluent which contains water; a foaming agent which allows the fixing solution to be in the form of foam; and plasticizers which soften or swell at least part of the fine resin particles, wherein the plasticizers contain a liquid plasticizer which is liquid at normal temperature and soluble in the diluent, and a solid plasticizer which is solid at normal temperature and soluble in the diluent.2012-05-31
20120135343TONER FOR ELECTROSTATIC CHARGE IMAGE DEVELOPMENT AND METHOD FOR PRODUCING THE SAME - Provided is a toner for an electrostatic charge image development having toner particles which contain: a binder resin; a colorant; and a compound represented by Formula (1) in an amount of 0.1 to 65 ppm based on the total weight of the toner particles:2012-05-31
20120135344TONER FOR DEVELOPING ELECTROSTATIC IMAGES AND METHOD FOR PRODUCING THE SAME - The present invention is to provide a toner for developing electrostatic images having a low minimum fixing temperature, and high hot offset resistance and high heat-resistant shelf stability, and a method for producing the toner. Also, the present invention is to provide a toner for developing electrostatic images, comprising a binder resin, a colorant, a release agent and a retention aid, wherein the retention aid is a copolymer of 70 to 98% by weight styrene and 2 to 30% by weight (meth)alkyl acrylate, and the copolymer has a glass transition temperature of 5 to 60° C.2012-05-31
20120135345DEVELOPER, METHOD FOR PRODUCING THE SAME, AND METHOD FOR EVALUATING THE SAME - According to one embodiment, a developer includes a toner which contains toner particles containing a binder resin and a coloring agent and also contains inorganic fine particles added to the surfaces of the toner particles, and is obtained through sieving after adding the inorganic fine particles to the toner particles, wherein a first adhesion force Fa1 (%) of the inorganic fine particles to the toner particles before sieving and a second adhesion force Fa2 (%) of the inorganic fine particles to the toner particles after sieving satisfy the following formulae (1) and (2).2012-05-31
20120135346PROCESSES FOR PRODUCING POLYESTER LATEXES WITH BIO-BASED SOLVENTS - A process for making a latex emulsion suitable for use in a toner composition includes contacting at least one polyester resin with a bio-based solvent to form a resin mixture, adding a neutralizing agent and deionized water to the resin mixture, removing the solvent from the formed latex, and recovering the emulsion. The solvent removed from the formed latex may be re-used, making the process very environmentally friendly.2012-05-31
20120135347RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, POLYMERIC COMPOUND AND COMPOUND - There are provided a resist composition, a method of forming a resist pattern using the resist composition, a novel polymeric compound and a compound useful as a monomer for the polymeric compound, 2012-05-31
20120135348ACTINIC-RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, ACTINIC-RAY-SENSITIVE OR RADIATION-SENSITIVE FILM, AND PATTERN FORMING METHOD - Provided are an actinic-ray-sensitive or radiation-sensitive resin composition which has improved development defect and is capable of forming a good pattern shape, an actinic-ray-sensitive or radiation-sensitive film formed using the composition, and a pattern forming method using the composition.2012-05-31
20120135349POSITIVE RESIST COMPOSITION AND PATTERNING PROCESS - A polymer obtained from copolymerization of a recurring unit having a carboxyl group and/or phenolic hydroxyl group substituted with an acid labile group with a methacrylate having a phenolic hydroxyl-bearing pyridine is useful as a base resin in a positive resist composition. The resist composition comprising the polymer is improved in contrast of alkali dissolution rate before and after exposure, acid diffusion control, resolution, and profile and edge roughness of a pattern after exposure.2012-05-31
20120135350POSITIVE RESIST COMPOSITION AND PATTERNING PROCESS - A positive resist composition comprising (A) a polymer comprising recurring units of a specific structure adapted to generate an acid in response to high-energy radiation and acid labile units, the polymer having an alkali solubility that increases under the action of an acid, and (B) a sulfonium salt of a specific structure exhibits a high resolution in forming fine size patterns, typically trench patterns and hole patterns. Lithographic properties of profile, DOF and roughness are improved.2012-05-31
20120135351SALT AND PHOTORESIST COMPOSITION COMPRISING THE SAME - The present invention provides a salt represented by the formula (I):2012-05-31
20120135352Preparation of Norbornane-based PAC Ballasts - Embodiments in accordance with the present invention provide for norbornane-type ballast materials, norbornane-type photoactive compounds derived from such ballast materials and alkali-soluble positive-tone polymer compositions that encompass such norbornane-type photoactive compounds and one of a PBO or PNB resin.2012-05-31
20120135353FUNCTIONALLY GRADIENT INORGANIC RESIST, SUBSTRATE WITH FUNCTIONALLY GRADIENT INORGANIC RESIST, CYLINDRICAL BASE MATERIAL WITH FUNCTIONALLY GRADIENT INORGANIC RESIST, METHOD FOR FORMING FUNCTIONALLY GRADIENT INORGANIC RESIST AND METHOD FOR FORMING FINE PATTERN, AND INORGANIC RESIST AND METHOD FOR FORMING THE SAME - A functionally gradient inorganic resist that changes in its state by heat, having a main surface irradiated with laser beams and a rear surface opposed to the main surface; the functionally gradient inorganic resist including a single layer resist, wherein at least a composition of the single layer resist is continuously varied from the main surface side to the rear surface side, and anisotropy of an area in which a temperature reaches a fixed temperature when being irradiated with laser beams locally, is continuously increased from the main surface side to the rear surface side in the single layer resist.2012-05-31
20120135354METHOD OF PRODUCING A RELIEF IMAGE FOR PRINTING - The present invention involves a method for making a relief image. A film that includes a carrier sheet and an imageable material is used to form a mask image that is opaque to a curing radiation. In one embodiment, the mask image is formed on the carrier sheet while in another embodiment, the mask image is formed on a receptor sheet. The mask image is then transferred to a photosensitive material, such as a flexographic printing plate precursor. The resulting assembly is exposed to the curing radiation resulting in exposed and unexposed areas of the photosensitive material. The carrier sheet or the receptor sheet may be removed from the mask image either before or after exposure to the curing radiation. Finally, the photosensitive material and mask image assembly is developed with a suitable developer to form a relief image.2012-05-31
20120135355METHOD OF FORMING PATTERNS - A method of forming patterns includes (a) coating a substrate with a resist composition for negative development to form a resist film having a receding contact angle of 70 degrees or above with respect to water, wherein the resist composition for negative development contains a resin capable of increasing the polarity by the action of an acid and becomes more soluble in a positive developer and less soluble in a negative developer upon irradiation with an actinic ray or radiation, (b) exposing the resist film via an immersion medium, and (c) performing development with a negative developer.2012-05-31
20120135356SEMICONDUCTOR DEVICE - A semiconductor device includes a memory cell array area, a peripheral circuit area on a periphery of the memory cell array area, and a boundary area having a specific width between the memory cell array area and the peripheral circuit area, the memory cell array area including a cell area including nonvolatile semiconductor memory cells, linear wirings extending from inside of the cell area to an area outside the cell area, and lower layer wirings in a lower layer than the linear wirings in the boundary area and electrically connected to the linear wirings, and wiring widths of the lower layer wirings being larger than widths of the linear wirings, the peripheral circuit area including a patterns electrically connected to the linear wirings via the lower layer wirings, the boundary area failing to be provided with the linear wirings and a wiring in same layer as the linear wirings.2012-05-31
20120135357POLYMER, POSITIVE RESIST COMPOSITION, AND PATTERNING PROCESS - A positive resist composition comprising a polymer comprising recurring units of a specific structure adapted to generate an acid upon exposure to high-energy radiation, recurring units of a lactone ring-containing structure, and acid labile units, all the recurring units being free of hydroxyl, can form a fine size pattern having a rectangular profile and improved collapse resistance.2012-05-31
20120135358COATING TREATMENT METHOD, COMPUTER-READABLE STORAGE MEDIUM, AND COATING TREATMENT APPARATUS - A substrate is first rotated at a first rotation speed, and a resist solution is applied. Rotation of the substrate is decelerated to a second rotation speed lower than the first rotation speed so that the substrate is rotated at the low speed to smooth the resist solution on the substrate. Rotation of the substrate is then accelerated to a third rotation speed higher than the second rotation speed, and a solvent for the coating solution and/or a dry gas are/is supplied to the resist solution on the substrate. The solvent gas is supplied to a portion of the resist solution on the substrate thicker than a set thickness, and the dry gas is supplied to a portion of the coating solution on the substrate thinner than the set thickness. This thins the thicker portion of the resist solution and thickens the thinner portion to uniform the resist solution.2012-05-31
20120135359Candle With Non-Consuming / Reusable Wick - A non consuming/reusable candle includes a wick that is a made of a porous sintered metal or alloy or of ceramic. The wick is conducive to wicking, via capillary action, any candle fuel for the purpose of combustion. The wick shape may be of any multiple geometrical shapes, and may be straight or curved, and provide either a narrow or broad flame. A wick holder can also be employed to hold the non consuming wick in place as well as to help with heat transfer to the body of the wax2012-05-31
20120135360Premix Flashback Control - An apparatus includes a furnace structure defining a combustion zone, and a tube that discharges fuel-oxidant premix into the combustion zone through an outlet from the tube. A reactant supply system provides the tube with unmixed fuel and oxidant for forming the premix. A flashback control means inhibits or extinguishes flashback in the tube.2012-05-31
20120135361GRATE COOLER PLATE HAVING ADJUSTABLE INSERT - A grate cooler plate including an air inlet and air passage openings through which the air flows for cooling the cooling goods present on the grate cooler plate. A rotatable insert having air passage openings is located in an upper surface of the grate cooler plate. The effect of the grate plate is that bulk goods placed in the inlet region of a grate plate cooler expand out to a flat cone of bulk goods.2012-05-31
20120135362GLASS MELTING FURNACE - The present invention relates to a furnace (2012-05-31
20120135363GLASS MELTING FURNACE - The present invention relates to a furnace (2012-05-31
20120135364ORTHODONTIC BRACKET WITH AUXILIARY SLOT - An orthodontic bracket includes a slot for attaching auxiliary attachments. The slot is formed into the pad of the bracket rather than being included in the bracket body. By forming the slot into the pad of the bracket rather than incorporating it into the bracket body, the slot may have a vertical orientation and may be centered on the bracket.2012-05-31
20120135365INTRAORAL ORTHODONTIC CORRECTOR - Provided are orthodontic corrector devices, related assemblies and methods which direct forces within the oral cavity. These corrector devices and assemblies include a flexible cantilever which is coupled to both a connector component and a force module. The cantilever acts to isolate adjacent components from mastication forces encountered during treatment. By resiliently deflecting in response to these inadvertent forces, the cantilever reduces the likelihood of device breakage and bond failure. Upon removal of these forces, the cantilever returns to its original orientation thereby maintaining the proper alignment of the corrector. Advantageously, the cantilever also allows the force module to be positioned further in the distal direction thereby enabling a greater range of connection options.2012-05-31
20120135366EASY ORTHODONTIC SLIDER - An orthodontic slider apparatus is disclosed. The orthodontic slider is used to apply intra or inter maxillary forces to distalize or mesialize teeth. The orthodontic slider of the current invention can easily be applied to the archwire of the fixed brackets of an orthodontic appliance without having to remove the archwire from the brackets. The slider utilizes self locking arms that allow it to easily attach to or detach from the archwire.2012-05-31
20120135367Wire Arches for Orthodontics - The invention relates to a wire arch for use in orthodontics wherein a white or tooth-colored shrink tube is shrunk onto the wire arch.2012-05-31
20120135368Modified-ouput fiber optic tips - A laser handpiece is disclosed, including a shaped fiber optic tip having a side-firing output end with a double bevel-cut shape. The shaped fiber optic tip can be configured to side-fire laser energy in a direction away from a laser handpiece and toward sidewalls of a treatment or target site.2012-05-31
20120135369Method and Impression Tray for Producing a Dental Mold - The invention relates to a method for producing a dental mold on the basis of a thermoplastic film (2012-05-31
20120135370TRANSFER COPINGS AND RELATED METHODS FOR TAKING IMPLANT IMPRESSIONS - A transfer coping configured to take an impression of an implant is disclosed. The transfer coping has an impression material contact portion and an implant mating portion. The implant mating portion has at least one support portion and at least one deflection portion configured to be received within an opening on a coronal portion of an implant. The at least one protrusion is disposed on the at least one deflection portion and is configured to engage in a snap-fit manner with a coordinating feature of an implant. A method for identifying the position of an implant in a patient is also disclosed.2012-05-31
20120135371SCANBODY FOR DETECTING THE POSITION AND ORIENTATION OF A DENTAL IMPLANT - Scanbody for detecting the position and orientation of a dental implant. A scanbody including a bottom section capable of being connected to an implant, and also a three-dimensional scannable region having an asymmetrical geometry permitting unequivocal detection of its surface from different scanning directions in relation to a longitudinal center axis of the scanbody. The scannable region is provided, on its peripheral cylindrical surface, with scannable sections that are radially offset outwardly and/or inwardly in relation to the peripheral cylindrical surface, each of which scannable sections is differently shaped from the other scannable sections.2012-05-31
20120135372Manufacturing Method Of A Guiding Template For Dental Implantology, Guiding Template Manufactured Thereby And Reference Device For The Execution Of Such Method - The present invention relates to a method for making a guiding template for dental implantation. The method provides for associating a base template to a reference device, subjecting the patient to CAT, loading the data to a computer program, making an implant planning, generating the volume model, coupling the volume model to the reference device model, projecting the elements of the implant planning on the volume model, making a volume suitably drilled on the basis of the projection, coupling the volume to the reference device and making the holes of the planning on the base template. The present invention also relates to the guiding template thus obtained and the reference device for carrying out the method.2012-05-31
20120135373DENTAL POSITIONING STENT, AND MANUFACTURING METHOD, USING METHOD AND COMPONENTS FOR THE SAME - A dental positioning stent for drilling an implant hole and a manufacturing method, a using method and components for the same are provided. The manufacturing method includes: slicing a tooth mold and a false tooth model along a preset slice plane; fixing two markers in the preset slice plane on two sides of the false tooth model respectively; covering the markers and the false tooth model with a shaping agent to form a positioning stent; putting the positioning stent on the teeth in a mouth to perform tomography imaging to acquire a slice image of the preset slice plane; mounting a positioning aid having a positioning hole in the positioning stent according to the slice image pasted up on the tooth mold to guide an initial drill. A dental positioning stent for tomography imaging, and a manufacturing method, a using method, and components thereof are provided.2012-05-31
20120135374Emergence Profile Guide for a Dental Bur - There are disclosed apparatus and method for obtaining a proper emergence profile for a dental implant. An emergence profile guide may be seated into an osteotomy and a dental bur may be guided onto and along the emergence profile guide. The emergence profile guide may include a pilot, and the dental bur may include a corresponding channel, such that the channel rides onto the pilot. The dental bur is stopped by the emergence profile guide, such that a countersink is created with an optimum depth.2012-05-31
20120135375DISPENSING DEVICE FOR A DENTAL SUBSTANCE - A dispensing device for a dental substance which comprises a body formed in a single piece. The body connects a first passageway and a second passageway which extend along different paths. The body further comprises a nozzle with a free dispensing end. The second passageway extends into the nozzle and tapers toward the dispensing end. The invention helps to reduce manufacturing costs, and helps facilitating handling of the device.2012-05-31
20120135376Collagen Biomaterial Wedge - A biocompatible, resorbable collagen membrane having a wedge shape with a thick edge of relatively higher strength and rigidity and a thin edge of relatively higher deformability and elasticity, which membrane is bendable to a desired configuration and is sufficiently rigid to retain the bent configuration upon implantation at a surgical site; a method of making such a membrane, and the use of such a membrane in a “sinus lift” procedure for augmenting alveolar bone.2012-05-31
20120135377DENTAL OBTURATOR POINT - Dental obturator point having an obturation body containing a composite material comprising (a) a polymer and b) a particulate filler, whereby the obturation body has a radio opacity of at least 3 mm/mm Al, characterized in that the composite material has (i) a tensile strength of from 5 to 70 MPAl (ii) a flexural strength of from 5 to 90 MPA, (iii) a flexural module of from 0.1 to 2.5 GPa, and which has (iv) a 300 rpm drilling coefficient at 37° C. in the range of from −1 to 7.00.2012-05-31
20120135378FASTENING SCREW FOR PROSTHETIC COMPONENTS IN IMPLANTODONTICS - Fastening screws for prosthetic components are provided with a thread achieved by a rolling process (thread rolling). These fastening screw are connected to the fitted screw of universal trunnion CM, angled universal trunnion CM, angled conic mini pillar CM over the dental implant CM (Morse Cone system) intraorally placed. The screw can be used in a variety of prosthetic components line for CM dental implants (Morse Cone system) and other implants lines (outer hexagon, inner hexagon, etc.). The screw made by the rolled thread process provides stronger screws that can be used to fasten prosthetic components onto various dental implants.2012-05-31
20120135379ALVEOLAR BONE GRAFT PROCESSING METHOD AND ALVEOLAR BONE GRAFT THEREFROM AND METHOD FOR TREATMENT USING ALVEOLAR BONE GRAFT - The present invention discloses an alveolar bone graft, a processing method thereof, and a method of treatment using the same. The processing method of the present invention comprises the steps of: (a) separating the tooth gathered from a patient into a crown and a root; (b) removing soft tissues and enamels within neurons of the crown and the root; (c) washing the crown and the root taken in step (b); (d) forming a number of holes in the washed crown and the root; (e) dewatering, degreasing and decalcifying the crown and the root having a number of holes; and (f) freeze-drying the crown and the root. The present invention allows the safety of an implant operation to be improved; and a metastasis of infectious diseases of allograft, xeno (animal) graft to be prevented by using the patient's own tooth. Also, the present invention allows an autogenous bone graft to be possible without additional operations.2012-05-31
20120135380IMPLANT ANALOG - The invention relates to an implant analog for placing in a jaw model for modeling a dental prosthesis by means of the jaw model. Said analog comprises a sleeve extending in an axial direction and comprising an axial inner bore having an internal thread for threading in a fastening screw for fastening a post to the implant analog, wherein the post is provided for fastening a dental prosthesis. According to the invention, the sleeve comprises a self-tapping external thread for threading in the implant analog into a jaw model. The invention further relates to a method for applying such implant analogs and an implant system having such implant analogs.2012-05-31
20120135381Immersive training scenario systems and related methods - Immersive training scenario systems and related methods are provided. The immersive training scenario systems can provide at least one simulated structure. The at least one simulated structure can include a base structure having at least one surface thereon. One or more substrates with one or more photographic images printed thereon are applied to the surface of the base structure so that the simulated structure has realistic visual characteristics representative of a mission site or mission scenario.2012-05-31
20120135382INDIVIDUALIZED MASTERY-BASED DRIVER TRAINING - Driver training methods, systems, and computer readable media are disclosed. A training method receives sensor information from a vehicle driven along a driving route by an individual, assesses performance of the individual based on the sensor information and an individual mastery level, and adjusts the individual mastery level based on the assessed performance of the individual. The method may be embodied in a computer readable media. A driver training system includes a receiver that receives vehicle sensor information associated with a vehicle being driven along a driving route by an individual and a processor coupled to the receiver that assesses performance of the individual based on the received sensor information and an individual mastery level and adjusts the individual mastery level based on the assessed performance of the individual. Driver training protocols and systems and methods for implementing and transforming driver training protocols are also disclosed.2012-05-31
20120135383MEAL PLATE FOR GUIDING CORRECT EATING HABITS AND ADJUSTING AMOUNT OF MEAL - A meal plate includes: a plurality of container receiving parts for receiving a container to serve food; an input part for inputting the kind of the food served in the container which is received in the container receiving parts; a measuring part disposed under the container receiving part for measuring information of the food served in the container; a storage part for storing the information of the food measured in the measuring part; and a communication part for transmitting the information of the food stored in the storage part to a user terminal.2012-05-31
20120135384PORTABLE TERMINAL, CALORIE ESTIMATION METHOD, AND CALORIE ESTIMATION PROGRAM - A portable terminal including: an imaging portion; a storage portion configured to store a database in which a plurality of foods and the calories thereof are associated with the shapes of containers and with the colors of the foods; a container detection portion configured to detect, from an image taken of a food slantwise at a predetermined angle to a horizontal direction, a container on which the food is placed; a container shape classification portion configured to classify the shape of the container detected by the container detection portion; a color detection portion configured to detect the container having been detected by the container detection portion; and a food estimation portion configured to estimate the food and the calories thereof from the database.2012-05-31
20120135385ORAL COMPOSITION AND METHOD FOR ENHANCING TASTING CAPABILITY AND TASTING INTELLIGENCE - An oral composition and a method for enhancing tasting capability and tasting intelligence involve applying the oral composition of a specific design to a user's mouth, wherein the specific design comprises allowing the oral composition to release successively one or more stimulating factors in the user's mouth over time; allowing the oral composition to provide the user with an innovative tasting experience constructed from music-like, graduated, rhythmic tasting and mouthfeel while the stimulating factors successively dissolve in and release to the user's mouth in a predetermined manner; and conducting diagnosis, training and/or enhancement of tasting capability and/or tasting intelligence of the user based on the user's individual music-like, graduated, rhythmic tasting and mouthfeel.2012-05-31
20120135386Relating psychological characteristics to on-screen drawings - A method and system for digitally relating psychological characteristics of a subject to on-screen drawings, comprising— 2012-05-31
20120135387DENTAL EDUCATIONAL APPARATUS AND METHOD - Apparatus for generating and recording video and audio associated with a dental procedure such as a dental or medical procedure comprises a video camera comprising a lens including an outermost refractive element. A light source comprises a plurality of light emitting devices. The light source is positioned adjacent the lens. The lens comprises an outer cylindrical surface. The outer cylindrical surface serves as a shade preventing light from entering the outermost refractive element. A support member supports the video camera at a plurality of positions. The instructor computer is coupled to the video camera for recording video output by the video camera. An instructor graphics input device is coupled to the computer for inputting graphical representations generated by the instructor into the instructor computer for inclusion in the video.2012-05-31
20120135388Online Proctoring - A system for secure, web-based, proctored examinations is provided. A web-based platform allows for test delivery beyond a local testing center with the test delivered directly to the test-taker. Computing devices that have been secured for the taking of an examination allow a student or prospective professional to access an examination wherever there is an Internet connection. As a result, students and professionals can take examinations where they live, learn, and work thereby reducing the costs associated with travelling to testing centers and minimizing time away from work. Test-takers, proctors, instructors, administrators, authors, and test developers can all access data and test information anytime and anywhere. Secure examinations can be taken under the purview of a proctor either in person or via the Internet and utilizing any number of testing environment capture devices in conjunction with data forensic technologies.2012-05-31
20120135389LEARNING ENVIRONMENT WITH USER DEFINED CONTENT - The invention relates to providing a computer based learning environment for a user wherein the user defines the content to be studied. The learning tool allows students to store and arrange located information in respect of a study topic, the material being in many different formats and from many sources, explore that located information, reinforce the material by testing their comprehension and understanding, allowing them to enquire further by expanding the information themselves or by collaboratively acquiring additional information/testing. The information/content to be studied by the user is established as a series of questions with answer, the format and content of each being determined by the user. In studying the invention allows the stored information to be displayed for a particular topic, whereas in testing the invention includes the further step of the user determining whether their answer to the question was correct.2012-05-31
20120135390PLASMA TREATMENT FOR GROWTH FACTOR RELEASE FROM CELLS AND TISSUES - Aspects of the present invention are related to methods comprising contacting an endothelial cell in an endothelial cell population with a non-thermal plasma to release an angiogenic growth factor. The released angiogenic growth factor may induce endothelial cell proliferation. In certain embodiments, the angiogenic growth factor is fibroblast growth factor-2. Preferably, the non-thermal plasma may be an atmospheric pressure dielectric barrier discharge. Additional aspects of the present invention are directed to methods for treating a disease comprising promoting angiogenesis by contacting an endothelial cell in a endothelial cell population with a non-thermal plasma to release an angiogenic growth factor. The angiogenic growth factor may induce endothelial cell proliferation. Further aspects of the present invention are directed to methods for treating a disease comprising inhibiting angiogenesis by contacting an endothelial cell in a endothelial cell population with a non-thermal plasma to reduce the number of endothelial cells in the population.2012-05-31
20120135391Method of Blood Pooling and Storage - The disclosure provides methods of making a cell-containing product having a uniform amount of cells therein. The method comprises pooling red blood cells from a plurality of blood units, and inactivating any pathogen contained therein. A storage solution added to the cellular component results in a cell-containing product that is essentially pathogen and white blood cell free and has an extended shelf life of about 42 to about 100 days. The cell-containing product is further divided into units which comprise a uniform dose of RBCs per unit.2012-05-31
20120135392ULTRASOUND STIMULATION DEVICES AND TECHNIQUES - Ultrasound stimulation devices and related techniques are disclosed. An ultrasound transducer for generating ultrasound energy is carried by a transducer housing that seals the transducer and may also include a positioning element for positioning the transducer proximate an application area to which generated ultrasound energy is to be applied. The transducer housing may also carry such components as a battery, a wireless receiver, and a controller. The same housing or a separate sensor housing may include an ultrasound sensor that provides feedback to the ultrasound transducer or its controller, illustratively through a wireless transmitter.2012-05-31
20120135393REAL-TIME PCR POINT MUTATION ASSAYS FOR DETECTING HIV-1 RESISTANCE TO ANTIVIRAL DRUGS - Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase or protease of HIV as disclosed herein. Thus, provided is an oligonucleotide comprising any one of the nucleotide sequences set for in SEQ ID NOS:1-89, and 96-104. Also provided are the oligonucleotides consisting of the nucleotides as set forth in SEQ ID NOS:1-89, and 96-104. Each of the disclosed oligonucleotides is a probe or a primer. Also provided are mixtures of primers and probes and for use in RT-PCR and primary PCR reactions disclosed herein. Provided are methods for the specific detection of several mutations in HIV. Mutations in both the reverse transcriptase and the protease of HIV can be detected using the methods described herein.2012-05-31
20120135394APPARATUS FOR INTEGRATED REAL-TIME NUCLEIC ACID ANALYSIS, AND METHOD FOR DETECTING A TARGET NUCLEIC ACID USING SAME - Provided are an apparatus for integrated real-time nucleic acid analysis and a method for detecting target a nucleic acid using the same, and more particularly an integrated real-time nucleic acid analysis for simultaneously performing qualitative analysis or quantitative analysis on genes from various kinds of plural biological samples and a method for detecting target a nucleic acid using the same. The apparatus for integrated real-time nucleic acid analysis and the method for detecting target a nucleic acid using the same according to the present invention, perform tests of various targets required from various samples through a single step promptly and accurately, and thus, can be efficiently used by hospitals or the like needing to rapidly diagnose diseases.2012-05-31
20120135395Methods and Compositions for Determining Altered Susceptibility of HIV-1 to Anti-HIV Drugs - This invention relates, in part, to methods and compositions for determining altered susceptibility of a human immunodeficiency virus (“HIV”) to the non-nucleoside reverse transcriptase inhibitors (“NNRTIs”) efavirenz (“EFV”), nevirapine (“NVP”), and delavirdine (“DLV”), the nucleoside reverse transcriptase inhibitor AZT, and the integrase strand transfer inhibitors diketo acid 1, diketo acid 2, and L-870,810 by detecting the presence of a mutation or combinations of mutations in the gene encoding HIV reverse transcriptase that are associated with altered susceptibility to the anti-HIV drugs.2012-05-31
20120135396Multi-Shell Microspheres With Integrated Chromatographic And Detection Layers For Use In Array Sensors - The development of miniaturized chromatographic systems localized within individual polymer microspheres and their incorporation into a bead-based cross-reactive sensor array platform is described herein. The integrated chromatographic and detection concept is based on the creation of distinct functional layers within the microspheres. In this first example of the new methodology, complexing ligands have been selectively immobilized to create “separation” layers harboring an affinity for various analytes. Information concerning the identities and concentrations of analytes may be drawn from the temporal properties of the beads' optical responses, Varying the nature of the ligand in the separation shell yields a collection of cross-reactive sensing elements well suited for use in array-based micro-total-analysis systems.2012-05-31
20120135397HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) DETECTION METHOD AND KIT THEREFOR - The invention provides oligonucleotide(s) derived from the gene sequence encoding the gag region of HIV-I for simple, specific and/or sensitive test(s) for the presence of HIV-I. In particular, the present invention provides oligonucleotide(s) for test(s) for HIV-I. Kit(s) comprising the oligonucleotide(s) for use as probe(s) and/or primer(s) useful in the test(s) are also provided.2012-05-31
20120135398Method of Detection and Related Detection Device - A method that uses an (DOPC) surfactant based biofilm that reacts with a material in a known manner, and a device that utilizes such a biofilm, to detect a material of interest is provided. The principles of the present invention are particularly useful in detecting/measuring a material that is harmful to a human or to property.2012-05-31
20120135399CANCER BIOMARKER AND METHODS OF USING THEREOF - Described herein are biomarkers which can be used for identifying a subject at risk for or evaluating the progression of cancer. In certain aspects, these biomarkers can be used to identify cancer stem cells. These biomarkers can include, but are not limited to, Oc1 or molecular variants thereof, Oc1 target proteins, or a combination thereof. In addition, described herein are methods for reducing the expression of these biomarkers associated with cancer.2012-05-31
20120135400Novel Fluorescent and Colored Proteins, and Polynucleotides that Encode These Proteins - The subject invention provides new fluorescent and/or colored proteins, and polynucleotide sequences that encode these proteins. The subject invention further provides materials and methods useful for expressing these detectable proteins in biological systems.2012-05-31
20120135401Methods and Compounds for the Diagnosis of Inflammatory Disease and Identification of Pharmacological Agents Useful in the Treatment of Inflammatory Disease - Methods for the diagnosis of inflammatory bowel diseases and the identification of agents useful in the treatment of such diseases based upon the agent's effect on reducing Pim-2 expression.2012-05-31
20120135402GENE SEQUENCE VARIANCES IN GENES RELATED TO FOLATE METABOLISM HAVING UTILITY IN DETERMINING THE TREATMENT OF DISEASE - The present disclosure describes the use of genetic variance information for folate transport or metabolism genes or pyrimidine transport or metabolism genes in the selection of effective methods of treatment of a disease or condition. The variance information is indicative of the expected response of a patient to a method of treatment. Methods of determining relevant variance information and additional methods of using such variance information are also described.2012-05-31
20120135403FIBROSIS SUSCEPTIBILITY GENE AND USES THEREOF - The present invention discloses the identification of a fibrosis susceptibility gene locus, the CTGF gene locus, which can be used for detecting predisposition to, diagnosis and prognosis of fibrosis as well as for the screening of therapeutically active drugs. The invention resides, in particular, in a method which comprises detecting in a sample from the subject the presence of an alteration in the CTGF gene locus, the presence of said alteration being indicative of the presence or predisposition to fibrosis.2012-05-31
20120135404OPTOELECTRONIC DETECTION SYSTEM - The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.2012-05-31
20120135405INSTRUMENT AND METHOD FOR OPTICAL PARTICLE SENSING - A new device capable of measuring the number of particles present in a colloidal suspension is disclosed, which includes a forward scatter detector, an extinction detector, a laser beam, a cylindrical lens with which to create a plane of light through which particles can pass, and the various pumps and tubing needed to pass the colloidal suspension through the plane of light. The device is particularly designed for measuring particles which have different refractive indices, and which are in the size range of between about 0.7 to 2 microns. The device can determine the presence or absence of biological particles of interest in a given sample, by incubating a sample with a given ratio of active particles and marker particles, and determining whether the ratio of active particles and marker particles has changed. Additional binding and/or non-binding particles can also be present, and kits including the particles are also disclosed.2012-05-31
20120135406METHOD FOR DETERMINING LYMPH NODE METASTASIS IN CANCER OR RISK THEREOF AND RAPID DETERMINATION KIT FOR THE SAME - The objective of the present invention is to provide a method and a means of rapidly and reliably detecting lymph node metastasis in cancer or the risk of lymph node metastasis. Specifically, the present invention provides a method and a rapid determination kit for detecting lymph node metastasis in cancer or its risk by identifying a certain genetic polymorphism of the human CRP gene, and it is clinically significant in determining the treatment strategy, because effective prediction/determination can be made regarding lymph node metastasis, which is an important phenomenon in cancer progression.2012-05-31
20120135407Compositions and Methods for Intramolecular Nucleic Acid Rearrangement - Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or MID). Compositions, kits and systems that find use in carrying out the reflex processes described herein are also provided.2012-05-31
20120135408UNC-45A SPLICE VARIANTS BASED CANCER DIAGNOSTICS AND THERAPEUTICS - Methods and compositions to diagnose and treat cancers using UNC-45A splice variants are disclosed. Expression of a human UNC-45A929 splice variant that is shorter than UNC-45A944 splice variant is increased in cancer cells including metastatic cancers. siRNA to inhibit or downregulate UNC-45A splice variants in cancers are disclosed.2012-05-31
20120135409METHODS OF MONITORING CONDITIONS BY SEQUENCE ANALYSIS - There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer. Provided herein are methods for using DNA sequencing to identify personalized biomarkers in patients with autoimmune disease and other conditions. Identified biomarkers can be used to determine the disease state for a subject with an autoimmune disease or other condition.2012-05-31
20120135410METHOD FOR IMAGING ON THIN SOLID-STATE INTERFACE BETWEEN TWO FLUIDS - Described herein is a fluid cell for an optical microscopy tool having a solid state membrane having a first side and a second, opposing side; a first fluid chamber comprising a first fluid having a first refractive index located on the first side of the membrane; and, a second fluid chamber comprising a second fluid having a second refractive index located on the second side of the membrane, the second refractive index being different than the first refractive index. Also described herein is a method for imaging a single biomolecule, the method including generating a field of evanescent illumination at a solid state membrane between a first fluid and a second fluid having different refractive indexes; and detecting light emitted by optical detectors linked to the single biomolecules at the solid state membrane.2012-05-31
20120135411PYROCOCCUS FURIOSUS STRAINS AND METHODS OF USING SAME - Provided herein are methods for transforming a 2012-05-31
20120135412QUALITY CONTROL BIOASSAYS FOR NUTRICEUTICAL AND MEDICINAL PRODUCTS - Bioassays for detecting the ability of one sample of a food substance, nutritional supplement, therapeutic agent and/or disease preventive agent relative to that of a second sample of such a substance, supplement and/or agent to inhibit, upregulate or otherwise modulate translation initiation, and thereby demonstrate a disease curative and/or preventive effect in a human and/or animal that consumes a such substance, supplement and/or agent or to whom a such substance, supplement and/or agent is administered are provided.2012-05-31
20120135413COMPOSITIONS FOR USE IN SECURITY MARKING - A composition comprising: a plurality of identical first synthetic nucleotide oligomers; and a plurality of identical second synthetic nucleotide oligomers which are different to the first synthetic nucleotide oligomers, wherein each of the first synthetic nucleotide oligomers comprises a first primer binding sequence of bases, a first identifier sequence of three to seven bases in length, and a second primer binding sequence of bases, the first identifier sequence being disposed between the first and second primer binding sequences, wherein each of the second synthetic nucleotide oligomers comprises a third primer binding sequence of bases, a second identifier sequence of three to seven bases in length, and a fourth primer binding sequence of bases, the second identifier sequence being disposed between the third and fourth primer binding sequences, and wherein the first identifier sequence is different to the second identifier sequence.2012-05-31
20120135414CHEMICALLY-ENHANCED PRIMER COMPOSITIONS, METHODS AND KITS - A composition is provided comprising a negatively charged group, an oligonucleotide sequence and at least none or one nuclease-resistant linkage group to form a chemically-enhanced primer. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the primer as well as a method of preparing DNA for sequencing and a method of sequencing DNA and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition under conditions in which excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded.2012-05-31
20120135415DETECTING CANCER WITH ANTI-CXCL13 AND ANTI-CXCR5 ANTIBODIES - Methods for diagnosing cancer in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a normal level of expression of the one or more cancer markers. The one or more cancer markers comprises CXCL13 or CXCR5 or both CXCL13 and CXCR5. Also disclosed is a kit for detecting cancer or monitoring cancer progression.2012-05-31
20120135416Compositions And Methods For Treating And Diagnosing Pancreatic Cancer - The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides pancreatic cancer stem cells useful for the study, diagnosis, and treatment of solid tumors.2012-05-31
20120135417METHODS FOR SCREENING AND IDENTIFYING COMPOUNDS - Methods, compositions and assays that measure the effect of a test compound on induction of ligand-induced ribowitch-mediated transcription termination are disclosed. The methods and the assays are useful in identifying drug candidates that modulate transcription by binding to a riboswitch, for example.2012-05-31
20120135418Automatic Detection Kit for Detecting HLA Alleles Using Real-Time Polymerase Chain Reaction - Provided is an automatic detection kit for automatically detecting HLA alleles using a real-time polymerase chain reaction (PCR). The real-time PCR is performed on DNA isolated from a sample using a primer which is able to specifically bind to HLA alleles and a fluorescent probe which is able to detect amplification of the HLA alleles in real time, and the HLA allele typing is performed by analyzing a fluorescence value obtained from the real-time PCR using an HLA automatic typing program.2012-05-31
20120135419Method of Determination of Diagnosis and Prognosis in Patients with B-cell Chronic Lymphocytic Leukemia and Oligonucleotides for Use in this Method - The invention provides a method of determination of diagnosis and prognosis of B-cell chronic lymphocytic leukemia from a biological sample collected from the body of a patient, wherein the status of Wnt/PCP signaling pathway is determined. Within the framework of the present invention the relation of CLL and molecular signaling pathway Wnt/PCP the components of which are markedly up-regulated in B-lymphocytes of the patients suffering from CLL was identified. The status of the Wnt/PCP signaling pathway can be determined, e.g., by the determination of the expression of components of said signaling pathway or by the determination of migration of CLL cells in the gradient of a chemokine in the presence of the ligand of said signaling pathway. The invention also relates to suitable oligonucleotides for use in the method of determination of expression of the signaling pathway components.2012-05-31
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