16th week of 2011 patent applcation highlights part 27 |
Patent application number | Title | Published |
20110091850 | Vision application training device - The present invention is directed to a vision applications training device prevent head tilting when appropriate, which comprises: a main housing; an ear attachment means connected to the main housing, and having a first and second component connected to one another to be movable relative to one another from a first, open, position to a second, closed, position and arranged to create the closed position for fixed placement on a human ear; a speaking tilt alarm system within the main housing includes a battery, a sound chip, a speaker, a tilt activation mechanism and functional connections, the sound chip having at least one speaking command; and, wherein a user may attach the device to the user's ear and when the user's head tilts at least a predetermined angle from horizontal, the tilt activation mechanism activates the chip and the at least one speaking command is played through the speaker. | 2011-04-21 |
20110091851 | MULTI-PURPOSE SOLITAIRE / REHABILITATION / EDUCATION TOOL FOR ASSISTING PATIENTS / STUDENTS / USERS TO IMPROVE MEMORY AND EYE / HAND COORDINATION - A multi-purpose tool may be used for assisting patients, students and/or users to improve memory and eye/hand coordination. The tool may be used for a number of functions, including solitaire games, rehabilitation or education. The tool may be in the form of a board having a slot in an upper frame member. Below the upper frame member may be seven spaces, and below the seven spaces may be vertical dividers. | 2011-04-21 |
20110091852 | SYSTEM AND METHOD FOR CARDIAC DEFIBRILLATION RESPONSE SIMULATION IN HEALTH TRAINING MANNEQUIN - Configurations for simulation of motions or movement in a health training mannequin for teaching purposes are disclosed. A cardiac defibrillation response simulation apparatus is configured to be housed separately from but interfaced with a health training mannequin to induce motion symptomatic response to electrical shock in the mannequin. In one embodiment a system comprises a motion inducer comprising a housing, an interface structure, and an actuator, wherein the interface structure is coupled to the actuator, movable relative to the housing, and configured to interface with a portion of a health training mannequin to induce motion in at least one portion of the health training mannequin. In another embodiment a method comprises interfacing a portion of a health training mannequin with an interface structure, the interface structure being coupled to an actuator and movable relative to a housing coupled to the actuator, the housing not being housed within a portion of the health training mannequin. Various hardware configurations are presented. | 2011-04-21 |
20110091853 | METHOD FOR SIMULATING A CATHETER GUIDANCE SYSTEM FOR CONTROL, DEVELOPMENT AND TRAINING APPLICATIONS - A system is disclosed for incorporating a realistic simulated catheter or catheters within a catheter guidance and control system that operate from the same closed-loop position control feedback and geometric mapping data as the real position control system and are able to make contact with real and simulated datasets. These catheters may be operated in a pure simulation mode without interacting with real catheters and position control hardware, or may be used as control cursors to enhance the placement of catheter positioning targets. The catheter tip, which is focus of magnetic control, is realistically guided by the control system parameters, while the remainder of the catheter line is realistically constrained by the mapped chamber geometry and introducer sheath. | 2011-04-21 |
20110091854 | SYSTEM AND METHOD FOR SEIZURE SIMULATION IN HEALTH TRAINING MANNEQUIN - Configurations for simulation of motions or movement in a health training mannequin for teaching purposes are disclosed. A seizure simulation apparatus is configured to be housed separately from but interfaced with a health training mannequin to induce oscillatory motion symptomatic of a neurological seizure or similar disorder in the mannequin. In one embodiment a system comprises a motion inducer comprising a housing, an interface structure, and an actuator, wherein the interface structure is coupled to the actuator, movable relative to the housing, and configured to interface with a portion of a health training mannequin to induce oscillatory motion in at least one portion of the health training mannequin. In another embodiment a method comprises interfacing a portion of a health training mannequin with an interface structure, the interface structure being coupled to an actuator and movable relative to a housing coupled to the actuator, the housing not being housed within a portion of the health training mannequin. Various hardware configurations are presented. | 2011-04-21 |
20110091855 | PELVIC SURGERY TRAINING MODEL - A male or female human pelvic model for teaching, practicing, or evaluating proficiency in physical examination, medical or surgical techniques, or procedures involving the pelvis are disclosed. The pelvic model can include replaceable pelvic skeletal frame and normal, pathological, or other modules providing 3D anatomical representations of various body components, such as skin, organs, muscles, vessels, connective tissues, ligaments, tendons, or nerves. The pelvic model can include portions that can retain pressurized fluid, such as to mimic a body organ, cavity, or vessel that retains fluid, so that leakage can occur, such as upon unintended cutting or puncture. A rotating open-top pelvic region structure can permit viewing or video capture during the simulated procedure. | 2011-04-21 |
20110091856 | OPTHALMOSCOPE SIMULATOR - An ophthalmoscope simulator for simulation and a method for simulation of the handling of an ophthalmoscope, having a support that can be attached to a head of an observer, at least one first imaging display disposed on said support, wherein the display can be placed in front of an eye of the observer for displaying a virtual reality, an ophthalmoscope dummy that can be supported by one hand of the observer, a position recognition system for determining the spatial position and/or orientation of the support and of the ophthalmoscope dummy and a computer for displaying an image of an environment, a patient head and/or at least a portion of the ophthalmoscope dummy on the display. In particular, a patient head dummy is provided that comprises at least one peripheral surface with a patient eye position defined therein, wherein the spatial position and/or orientation of the patient head dummy can be determined and displayed by way of the position recognition system and that in addition to or alternative to the ophthalmoscope dummy an image portion can be added to the image displayed to the observer, wherein the image portion represents a virtual retina as could selectively appear to the observer, taking into account the spatial position of the support, the ophthalmoscope dummy and the patient head dummy. | 2011-04-21 |
20110091857 | MODULAR TAXIDERMY MANNEQUIN EAR ASSEMBLY - The present invention is a taxidermy mannequin which includes an optional ear engagement area formed on a head portion, a lock plate which is secured to the ear engagement area, and an ear liner which is connected to the lock plate. | 2011-04-21 |
20110091858 | TAXIDERMY MANNEQUIN HAVING INTERCHANGEABLE FEATURES - The present invention is a taxidermy mannequin having a mounting portion generally in the shape of an animal body, and a display portion generally in the shape of an animal head, wherein the mounting portion and display portion are secured together through a universal connection, thereby the taxidermist may choose different display portions to secure to the mount portion. The present invention further includes a plurality of selectively interchangeable features which are secured to the display portion. The features include a nose, a jaw, an eye, an ear liner, and a nictitating membrane. | 2011-04-21 |
20110091859 | Method for Online Learning - A curriculum is created aligned closely to the state standards. This is broken down into tiny units called factoids, analogous to atoms in chemistry. The factoids are converted into question-and-answer pairs. These are placed on electronic flashcards so that they can be sorted according to the degree of mastery. There is a question on one side and an answer on the other. They are answered mentally. A user/student can choose from the options “Show again: Today, A, B, C, or Never” depending on his/her understanding of the question. A software system remembers each student as an individual and the status of each flashcard that the student has attempted to answer. There are five tiers in the classification system: school> year> subject> topic> and subtopic. A subtopic would contain from 10 to 100 flashcards depending upon the grade level. | 2011-04-21 |
20110091860 | MAGNETIC GLASS DRY ERASE BOARD - A magnetic glass dry erase board including a glass sheet, a metal sheet and an adhesive layer. The glass sheet has an inner surface and an outer surface. The metal sheet has an inner surface and an outer surface. The adhesive layer substantially covers the inner surface of the glass sheet and the outer surface of the metal sheet to retain the glass sheet in a stationary relationship with respect to the metal sheet. The adhesive layer also enhances a strength of the glass sheet and protects persons from injury if the glass sheet is broken by retaining glass pieces on the metal sheet. | 2011-04-21 |
20110091861 | Practice Gown - A clothing attachment that serves as a practice gown by connecting over the clothing of a wearer such that the clothing attachment is configured with weight, volume, and length markers to simulate the conditions of wearing a complete dress under actual conditions of that dress. In this manner, a wearer can simulate and otherwise practice engaging in activities for a wedding or ballroom dancing without risking damage to the actual dress or gown. | 2011-04-21 |
20110091862 | GENERATION OF AN HLA-NEGATIVE OSTEOGENIC PRECURSOR CELL LINE - The present disclosure provides methods for producing human osteogenic cell lines in which HLA Class I expression is absent or reduced. The resulting osteogenic cells can then be used, for example, to form mineralized three-dimensional bone constructs which can be used, for example, in bone grafting procedures. The lack of HLA Class I expression in the cells of the mineralized three-dimensional bone constructs reduces or eliminates the potential for host-graft rejection. | 2011-04-21 |
20110091863 | Blood Substitute Solution - The invention relates generally to blood substitute solutions and methods for using blood substitute solutions. The solutions may be used in a variety of applications and are particularly suited for use in applications where at least a portion of a host's blood is replaced with a substitute solution. | 2011-04-21 |
20110091864 | Device And Use Thereof - Disclosed herein is a device comprising at least one supporting solid surface comprising at least one membraneophilic region; a covering layer that is at least partially immobilized to the membraneophilic region, said covering layer consisting of (i) a surfactant membrane, (ii) a lipid mimicking polymer, (iii) a surfactant or emulsion system or (iv) a liquid crystal; and a substance included in or bound to, connected to or associated with the covering layer. Also disclosed are methods wherein the device is used and use of the device. | 2011-04-21 |
20110091865 | MEASURING MULTIPLE ANALYTES OVER A BROAD RANGE OF CONCENTRATIONS USING OPTICAL DIFFRACTION - The invention relates to method, devices, and kits for measuring multiple analytes in a sample having a broad range of concentrations using optical diffraction. Devices, methods, and kits useful for monitoring and diagnosing diabetes, cardiovascular disease, thyroid disease, hormone-related conditions, and sepsis are also described. | 2011-04-21 |
20110091866 | DETECTION OF POLYOMAVIRUS - Methods and kits are provided for testing for the presence or absence of a polyomavirus, such as BKV, in a sample. The methods and kits are useful for quantifying BKV and differentiating BKV from JCV. | 2011-04-21 |
20110091867 | METHOD TO IDENTIFY AND PREDICT DISEASE PROGRESSION OF HUMAN PAPILLOMA VIRUS-INFECTED LESIONS - The present invention provides a method for distinguishing benign human papilloma virus (HPV)-infected tissue from HPV-related lesions that have undergone malignant transformation. In one embodiment, the invention comprises a simple histochemical staining method and details a novel process for examining HPV-infected cells by determining susceptibility to enzymatic DNA digestion. Residual virion-associated DNA is seen only in benign HPV-infected lesions, while absence of residual DNA is seen with malignant transformation. In another embodiment, the invention comprises immunohistochemical assay methods for examining HPV-infected cells, utilizing antibodies to HPV L1 proteins. These methods can be used to predict biologic behavior of HPV-infected lesions. The invention can improve current cervical cancer screening programs, and improve clinical management of patients by defining malignant potential of HPV-infected tissue more accurately. | 2011-04-21 |
20110091868 | NOVEL ANTIGEN CONSTRUCTS USEFUL IN THE DETECTION AND DIFFERENTIATION OF ANTIBODIES TO HIV - Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention. | 2011-04-21 |
20110091869 | METHOD FOR CULTURE OF STEM CELL - The present invention enables efficient suspension culture of stem cells in a serum-free medium by comprising a step for quickly forming a homogenous aggregate of stem cells, and provides a method of selectively inducing the differentiation of nerves from a stem cell, a method of forming a cerebral cortical nerve network in vitro, and a method of producing a steric structure of a brain tissue in vitro, as well as a method of producing hypothalamic neuron progenitor cells, comprising culturing pluripotent stem cells as a suspended aggregate in a serum-free medium that substantially does not contain a Nodal signal promoter, a Wnt signal promoter, an FGF signal promoter, a BMP signal promoter, retinoic acid and an insulin, and isolating hypothalamic neuron progenitor cells from the culture. | 2011-04-21 |
20110091870 | MULTISITE BIOSENSOR AND ASSOCIATED METHOD - A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals. | 2011-04-21 |
20110091871 | BIOMARKERS FOR PREDICTING RESPONSE OF ESOPHAGEAL CANCER PATIENT TO CHEMORADIOTHERAPY - The present invention relates to novel genetic markers associated with response of a patient with esophageal cancer (ECa) to chemoradiation therapy, and particularly to methods and kits for predicting an ECa patient's response to chemoradiation therapy by genotyping of the markers. | 2011-04-21 |
20110091872 | DETECTING TRIAZOLE RESISTANCE IN ASPERGILLUS - Methods are provided for detecting triazole -resistant fungi in a sample. The methods comprise evaluating the sample for the presence of a gene encoding a mutant AzRF1 transcription factor, or the level of the transcription factor, to determine whether a fungus is triazole-resistant. Primers, probes and kits also are provided. | 2011-04-21 |
20110091873 | INTEGRATED SAMPLE PREPARATION AND AMPLIFICATION FOR NUCLEIC ACID DETECTION FROM BIOLOGICAL SAMPLES - Beads are used to perform both a sample preparation and amplification process within a single processing chamber. A fluid sample including a plurality of cells is introduced into a processing chamber already including a plurality of beads. The plurality of cells are lysed within the processing chamber, and nucleic acid released from the lysed cells binds to the beads. The beads are retained in the processing chamber while the lysing reagents are removed. Amplification reagents, such as PCR reagents are added to the processing chamber and an amplification process is performed on the contents of the processing chamber. Nucleic acid captured on the beads is not eluted for amplification, instead amplification of the captured nucleic acid is performed while the nucleic acid is still bound to the beads. During the amplification process, the nucleic acid bound to the beads is amplified. Real-time or end-point detection can be performed on the content of the processing chamber to detect the presence of amplified product. | 2011-04-21 |
20110091874 | ULTRASENSITIVE DETECTION OF TARGET USING TARGET-READY PARTICLES - The invention relates to methods and reagents for detecting minute amounts of targets having affinity for nucleic acid. The present invention more particularly relates to target detection using aggregates of cationic polymer chains and nucleic acid capture probes linked to particles, such as controllable mobility particles. | 2011-04-21 |
20110091875 | THREE-COMPONENT GENE EXPRESSION REPORTING SYSTEM FOR MAMMALIAN CELLS AND APPLICATIONS OF THE SAME - Disclosed herein is a three-component gene expression reporting system for mammalian cells, the system including a first expression cassette, a second expression cassette, and a methylated polynucleotide. The three-component gene expression reporting system can be used to establish recombinant mammalian cells for use in the screening of a demethylating agent. | 2011-04-21 |
20110091876 | ZCYTOR19 POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE - Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto. | 2011-04-21 |
20110091877 | SYSTEMS AND METHODS FOR MINIMIZATION OR ELIMINATION OF DIFFUSION EFFECTS IN A MICROFLUIDIC SYSTEM - The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. | 2011-04-21 |
20110091878 | DAIRY CATTLE BREEDING FOR IMPROVED MILK PRODUCTION TRAITS IN CATTLE - Nucleic acid molecules comprising a SNP site at position 1296 of bovine uterine milk protein (UTMP) coding sequence (SEQ ID NO: 1), which SNP indicates a desirable productive life in a dairy cattle. Also disclosed are an array or a kit comprising the same, a method for detecting the SNPs, a method for progeny testing of cattle, and a method for selectively breeding of cattle. | 2011-04-21 |
20110091879 | MOBILE DEVICE FOR ISOLATION OF NUCLEIC ACIDS - The invention relates to a mobile device system, comprising a hand-held device and a test kit for the mobile isolation of nucleic acids. The hand-held device comprises at least one sample block for inserting sample containers, a sample block holder with boreholes or recesses for accommodating the sample blocks, a device base with electronic control units for the sample blocks, a voltage source and a connection to the sample block holder, as well as a test kit for the isolation of nucleic acids. The hand-held device is characterized in that the sample blocks can be removed from the sample block holder and the sample block holder can be removed from the device base. | 2011-04-21 |
20110091880 | SUSCEPTIBILITY VARIANTS FOR LUNG CANCER - The present invention discloses certain genetic variants as susceptibility variants for lung cancer. The invention relates to methods of risk assessment using such variants. The invention further relates to kits for use in risk assessment of lung cancer. | 2011-04-21 |
20110091881 | MYCOBACTERIAL GENES DOWN-REGULATED DURING LATENCY - A method is provided for identifying mycobacterial genes the expression of which is down-regulated during a stationary phase culture of mycobacteria under nutrient-starving conditions when compared with an exponential phase culture of mycobacteria under culture conditions that are not nutrient-starving and that support exponential growth of said mycobacteria. The described method optionally provides for identifying mycobacterial genes that are simultaneously down-regulated under low DOT conditions. The down-regulated genes of the present invention form the basis of nucleic acid vaccines, or provide targets to allow preparation of attenuated mycobacteria for vaccines against mycobacterial infections. Similarly, peptides encoded by said down-regulated genes are employed in vaccines. In a further embodiment, the identified genes/peptides provide the means for identifying the presence of a mycobacterial infection in a clinical sample by nucleic acid probe or antibody detection. | 2011-04-21 |
20110091882 | DETERMINATION OF METHYLATION STATUS OF POLYNUCLEOTIDES - The present invention provides compositions and methods for detecting the methylation status of a nucleic acid. In particular, the present invention provides a mass spectrometry-based method of determining DNA methylation status without sequencing. | 2011-04-21 |
20110091883 | METHODS FOR ANALYZING MINUTE CELLULAR NUCLEIC ACIDS - The invention generally relates to methods for analyzing cellular nucleic acid. Methods of the invention involve capturing RNA from a lysed cell onto a substrate, producing a cDNA/RNA duplex, removing the RNA from the cDNA/RNA duplex, priming the cDNA to produce a primer/cDNA duplex, exposing the primer/cDNA duplex to at least one detectably labeled nucleotide in the presence of a polymerase capable of catalyzing addition of the nucleotide to the primer/cDNA duplex, detecting incorporation of the nucleotide into the primer portion, and repeating the exposing and detecting steps at least once. | 2011-04-21 |
20110091884 | Method for Analysis of DNA Methylation - Provided is a method for analysis of DNA methylation. A first method comprises: (1) a step in which analyte DNA is digested with methylation-insensitive restriction enzyme(s) that produce overhanging end(s) and that contain methylated cytosine or methylatable cytosine in recognition sequence(s) thereof; (2) a step in which adaptor(s) capable of regenerating recognition sequence(s) of the aforesaid methylation-insensitive restriction enzyme(s) is/are ligated to both ends of DNA fragment(s) obtained at the aforesaid step (1); and (3) a step in which DNA construct(s) obtained at the aforesaid step (2) is/are digested with methylation-sensitive restriction enzyme(s) that recognize the same recognition sequence(s) as the aforesaid methylation-insensitive restriction enzyme(s). A second method comprises: (1) a step in which analyte DNA is digested with restriction enzyme(s); (2) a step in which adaptor(s) is/are ligated to both ends of DNA fragment(s) obtained at the aforesaid step (1); and (3) a step in which DNA construct(s) obtained at the aforesaid step (2) is/are digested with methylation-dependent restriction enzyme(s). | 2011-04-21 |
20110091885 | COMPOSITION COMPRISING AN OLIGONUCLEOTIDE MIXTURE FOR THE DETECTION OF CONTAMINATIONS IN CELL CULTURES - The present invention relates to a method for determining contaminations in a cell culture sample comprising the steps of: a) contacting a sample of a cell culture suspected to comprise contaminations with a composition comprising oligonucleotides under conditions which allow for amplification of polynucleotides, wherein said oligonucleotides comprise oligonucleotides of at least three different groups of oligonucleotides, and b) determining the contaminations based on the amplified polynucleotides obtained by using the oligonucleotide groups of step (a). Moreover, the invention relates to a composition comprising an oligonucleotide mixture. Further encompassed by the present invention is a composition comprising a probe oligonucleotide mixture. Finally, the present invention also relates to kits comprising said oligonucleotide mixtures. | 2011-04-21 |
20110091886 | METHOD OF DISTINGUISHING INFLAMMATORY PATHOGEN CAUSING ACUTE RESPIRATORY INFECTION - Disclosed is a method of distinguishing an inflammatory pathogen causing acute respiratory infection wherein the pathogen to be distinguished is a pathogen residing in the respiratory tract, which comprises: (a) a step for counting gene copies originating in subject cells in DNA prepared from a specimen containing secretion from the respiratory tract of the subject; (b) a step for counting the gene copies originating in the pathogen in the DNA; (c) a step for calculating the relative value of count of the gene copies originating in the pathogen to the count of the gene copies originating in the subject cells; and (d) a step for distinguishing whether the pathogen is an inflammatory pathogen causing the disease or not based on the distinguishing standard and the relative value. | 2011-04-21 |
20110091887 | METHOD FOR DETECTION OF METHYLCYTOSINE USING PHOTORESPONSIVE PROBE - The present invention provides a method for detecting methylcytosine in DNA rapidly, conveniently, and with high sensitivity. The present invention relates to a method for detecting methylcytosine by using a methylcytosine photocoupling agent (a photoresponsive probe) consisting of nucleic acids having a group represented by the Formula (I), (II), (III) or (IV) as a base moiety. | 2011-04-21 |
20110091888 | USE OF CATHEPSIN C - Present invention concerns the use of Cathepsin C. Other aspects of the invention concern methods for screening pharmaceuticals, for diagnosing pain susceptibility and for the treatment of pain. | 2011-04-21 |
20110091889 | CENTROSOME-ASSAY - The present invention provides a centrosome assay for the identification of preferably, Eg | 2011-04-21 |
20110091890 | TRICHOPLUSIA NI CELL LINE AND METHODS OF USE - An isolated cell from the cell line identified as TnT4. This cell may be infected with a baculovirus expression vector which may carry a heterologous nucleotide that encodes a polypeptide, such as a membrane protein, e.g., human neurotensin receptor 1. Also included is a method for using this cell line to produce a polypeptide, such as a membrane protein; and a method for identifying a cell-of-interest which expresses a protein-of-interest. | 2011-04-21 |
20110091891 | PROBE, PROBE SET, PROBE CARRIER, AND TESTING METHOD - A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 3 and mutated sequences thereof. | 2011-04-21 |
20110091892 | Methods for the Diagnosis and Treatment of Lung Cancer - The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition. | 2011-04-21 |
20110091893 | BIOSENSORS FOR DETECTING MACROMOLECULES AND OTHER ANALYTES - The invention generally provides molecular biosensors. In particular, the invention provides molecular biosensors having one or more aptamers. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules. | 2011-04-21 |
20110091894 | OLIGONUCLEOTIDES FOR AMPLIFYING CHLAMYDOPHILA PNEUMONIAE NUCLEIC ACID - Oligonucleotides for use in determining the presence of | 2011-04-21 |
20110091895 | Immunoassays to Detect Diseases or Disease Susceptibility Traits - Disclosed are immunoassay methods for the diagnosis/prognosis of diseases and disease susceptibility traits associated with gene mutations that cause protein truncation or allelic loss. The levels of one or more targeted wild-type proteins expressed by a subject gene or genes are immunologically quantitated in biological samples. Results indicating that a targeted wild-type protein is not present in an assayed sample, or that approximately 50% of the normal amount of such a wild-type protein is present in an assayed sample are considered to be positive for a mutation in one or both alleles of a subject gene, and correlated with the disease or the disease susceptibility trait associated with that mutation or mutations. Normal cells, particularly normal peripheral blood lymphocytes, are preferred biological samples. | 2011-04-21 |
20110091896 | METHOD FOR ANALYSIS/IDENTIFICATION OF ANTIBODY GENE AT ONE-CELL LEVEL - Disclosed are: a method for identifying/analyzing a gene for an antibody in one cell derived from a human; a technique for producing an antibody derived from an identified one B cell; and others. A gene for an antibody specific to a melanoma antigen is analyzed/identified at a one-cell level by using an immortalized B cell produced from peripheral blood monocytes from a melanoma patient or a primary B cell included in the peripheral blood monocytes. It is found that B cells capable of producing a specific antibody can be separated on one cell by one cell basis by staining the B cells with a GST-labeled melanoma-specific cancer antigen MAGE1, an Alexa-labeled anti-GST antibody and a PE-labeled anti-human IgG antibody and carrying out the single cell sorting of the stained B cells. Further, a practical technique for extracting total RNA from the separated one B cell and cloning a gene for a specific antibody into the total RNA efficiently can be established. | 2011-04-21 |
20110091897 | COMPOSITIONS COMPRISING NANOMATERIALS AND METHOD FOR USING SUCH COMPOSITIONS FOR HISTOCHEMICAL PROCESSES - Histochemical process compositions comprising at least one nanoparticle in an amount effective to reduce or substantially eliminate the average number of spots per slide that result from a sample staining protocol are disclosed. Various nanoparticles, or combinations thereof, including metals, metal alloys, metal oxides, ceramics, functionalized metals or metalloids, and other miscellaneous nanoparticles, such as carbon nanoparticles and diamond nanoparticles, can be used. The nanoparticle concentration typically is from about 2 parts per million to about 20 parts per million. One embodiment of a disclosed method concerns applying a histochemical process composition to a sample, followed by performing a staining protocol on the sample. Particular embodiments concern dispensing a nanosolution onto a sample using an automated system, heating the sample, and performing a sample staining process. | 2011-04-21 |
20110091898 | DETECTION PROBE - A nucleotide probe permitting the detection of nucleic acids and constituted of a labeled nucleotide strand having three fragments: a first fragment having a first closing sequence, a second fragment, all or part of which has a recognition sequence for the molecular recognition of the target nucleic acid and a third fragment having a second closing sequence, and at least two markers, one of the ends of the strand of the detection probe being free of any marker, in which, when the two closing sequences are hybridized together, the detection probe has a completely circular shape, the closing sequences thus maintaining the probe in a conformation that cannot be detected in the absence of the target nucleic acid. | 2011-04-21 |
20110091899 | COMBINATION OF RISK ALLELES ASSOCIATED WITH AUTISM - The present invention relates to a method of detecting the presence of or predisposition to autism, or to an autism spectrum disorder, the method comprising detecting the presence of an alteration in the gene loci PITX1, ATP2B2, SLC25A12 and EN2 in a sample from said subject. More particularly, the presence of specific single nucleotide polymorphisms (SNPs) within these genes correlates to a substantially increased risk to develop autism. | 2011-04-21 |
20110091900 | METHOD FOR DETERMINING DNA COPY NUMBER BY COMPETITIVE PCR - The present invention relates to a method for determining the number of copies of DNA at a specific locus. The method comprises the step of co-amplifying a DNA sample of an exploratory species comprising the test locus with a competitor sample comprising an orthologous DNA sequence derived from a closely related species. | 2011-04-21 |
20110091901 | Vectors and Methods for Screening Cells for High Expression of Protein of Interest (POI) - This invention refers to industrial production of proteins. More particularly, the invention refers to a fusion protein as a novel chimeric selection marker comprising a peptide conferring resistance to an antibiotic, or a fragment, allelic variant, splice variant or mutein thereof, and at least one sequence comprising SEQ ID NO: 1, 2 or 3, preferably for producing a protein of interest (POI). The inventive chimeric selection marker exhibits: (i) a resistance to an antibiotic; and (ii) a fluorescence activity upon binding of a ligand to the sequence comprising SEQ ID NO: 1, 2 or 3. The invention further refers to nucleic acids encoding the inventive fusion protein and to expression vectors, comprising the inventive fusion protein and additionally the protein of interest (POI). Finally, uses of the inventive chimeric selection marker for screening cells for high expression of a protein of interest (POI) are disclosed. | 2011-04-21 |
20110091902 | METHOD OF ASSAYING PHYSIOLOGICALLY ACTIVE SUBSTANCE OF BIOLOGICAL ORIGIN, KIT FOR ASSAYING PHYSIOLOGICALLY ACTIVE SUBSTANCE OF BIOLOGICAL ORIGIN AND APPARATUS FOR ASSAYING PHYSIOLOGICALLY ACTIVE SUBSTANCE OF BIOLOGICAL ORIGIN - Provided is a technique whereby a physiologically active substance of biological origin such as an endotoxin or β-D-glucan can be more conveniently and accurately detected and the concentration thereof can be determined even in the case of using a sample which contains a substance affecting LAL activity. For example, a sample is brought into contact with a substance ( | 2011-04-21 |
20110091903 | METHOD OF ANALYZING A SAMPLE FOR A BACTERIUM USING DIACETYLENE-CONTAINING POLYMER SENSOR - The invention relates to methods of analyzing a sample for a bacterium of interest. In particular, the methods involve an initial capture process that includes the use of one or more antibodies having antigenic specificities for one or more distinct analytes characteristic of the specific bacterium. After initial capture of a specific bacterium, techniques of analyzing involve colorimetric techniques, particularly using colorimetric sensors that include polydiacetylene (PDA) materials. | 2011-04-21 |
20110091904 | METHOD FOR DETERMINATION OF AFFINITY AND KINETIC CONSTANTS - The invention is related to a method for quantification of a first dissociation equilibrium constant K | 2011-04-21 |
20110091905 | BIOCHIP AND METHOD OF DETECTING REACTION FROM THE SAME - Provided are a biochip and a method of detecting a reaction from the biochip. This method includes preparing a first mixture solution of polyvinylpyrrolidone (PVP) and a sample including target molecules, measuring absorbance or transmittance of the first mixture solution, preparing a second mixture solution including the PVP, the sample, and a receptor of the target molecules, measuring absorbance or transmittance of the second mixture solution, and calculating an absorbance or transmittance difference between the first mixture solution and the second mixture solution. Thus, it is possible to reduce the production cost of the biochip by inducing a reaction of an antigen and an antibody using PVP. Further, it is possible to detect an accurate quantity of the antigen by analyzing a quantity of antigen on the basis of the absorbance or transmittance difference. | 2011-04-21 |
20110091906 | Immuno gold lateral flow assay - A chromatographic specific binding assay strip device, comprising: a non-permeable platform strip; a permeable membrane testing strip positioned on top of said non-permeable platform strip, with the testing strip comprising at least one capture reagent site containing a capture reagent for at least one specific analyte, a sample receiving pad positioned on top of and at a proximal end of the non-permeable platform strip, with the sample receiving pad having contact with a proximal end of said permeable membrane testing strip, a reservoir pad positioned on top of and at a distal end of said non-permeable membrane testing strip, with the reservoir pad having contact with a proximal end of said permeable membrane test strip; a supporting strip attached to and extending from the proximal end of said non-permeable platform strip; and a conjugate pad positioned on said supporting strip, said conjugate pad comprising a semi-permeable membrane containing a colorant conjugate. The semi-permeable membrane acts as a barrier between the conjugate pad and the sample receiving pad, regulating the flow through the semi-permeable membrane and overall flow of the assay By dipping the conjugate pad into a sample solution, there will be increased binding between the analyte in the sample and the conjugate (preferably colloidal gold), thereby giving improved results on the lateral flow assay. | 2011-04-21 |
20110091907 | METHOD FOR DETECTION OF LIVER CANCER CELL USING ANTI-GLYPICAN-3 ANTIBODY - The present invention relates to an in-vitro immunoassay method for detecting the presence of liver cancer cells in a subject. In the method of the present invention, antigen retrieval treatment based on heat-induced epitope retrieval method and antigen retrieval treatment based on protease-induced epitope retrieval method can be combined in the detection of glypican 3 antigen expression in liver cancer tissues to thereby detect the difference in the expression level or expression pattern of the glypican 3 antigen by immunohistochemical staining method. This enables samples, which has been determined by the conventional HIER method as highly expressing glypican 3, to be graded according to the expression level of glypican 3. | 2011-04-21 |
20110091908 | EARLY PROSTATE CANCER ANTIGEN-2: A NOVEL SERUM SPECIFIC MARKER FOR PROSTATE CANCER DETECTION - Early Prostate Cancer Antigen-2 (EPCA-2) is a prostate cancer biomarker, newly identified via proteomics-based examination of alterations in nuclear structure. EPCA-2 shows a higher overall specificity than PSA. Thus, an immunoassay based on antibodies against an epitope of EPCA-2 more accurately differentiates between confined and non-confined disease than PSA or Gleason score. | 2011-04-21 |
20110091909 | Stabilizing Agents and Capture Ligands for Use in Assays Measuring Analyte Concentrations - The present invention is related to compositions useful for the measurement of free or unbound analyte concentrations in a fluid. The present invention includes the use of capture ligands and stabilizing agents to improve the accuracy of analyte concentration assays. Methods and tools for using the present invention are also disclosed. | 2011-04-21 |
20110091910 | NOVEL ASSAY - A novel method for detection of Aβ peptides, in particular in plasma, and to the use of Aβ peptides for diagnosis of Alzheimer's disease. | 2011-04-21 |
20110091911 | ANTIBODIES, SYSTEMS AND METHODS FOR DETERMINING RELATIVE HEMOLYTIC INDEX - Disclosed herein are antibodies, systems and methods for assessing the risk of hemolysis following a blood transfusion with crossmatch incompatible blood. The disclosure provides a method for determining the relative hemolytic index and therefore the risk of post-transfusion hemolysis for said patient. | 2011-04-21 |
20110091912 | HIGH MOLECULAR WEIGHT NGAL AS A BIOMARKER FOR CHRONIC KIDNEY DISEASE - A high molecular weight form of Ngal is provided which can be used to diagnose chronic kidney disease. High molecular weight Ngal is about 75 kDa to about 350 kDa, and comprises non-Ngal proteins, such as polymeric immunoglobulin receptor, alpha-2-macroglobulin and immunoglobulin heavy chain. Methods are disclosed for assessing high molecular weight Ngal in a diagnostic sample from a subject. | 2011-04-21 |
20110091913 | DRUG SAFETY TEST USING PENTRAXIN-3 (PTX-3) - The invention relates to an in vitro method for assessing the immunogenicity of a compound of interest comprising the steps of: a) providing a whole blood sample, wherein said blood was exposed to said compound of interest, b) measuring the level of pentraxin-3 in said sample, and c) comparing the measured level of pentraxin-3 with a control. | 2011-04-21 |
20110091914 | Immunological Test Element with Improved Control Zone - The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g., an enzyme, fluorescent or direct label, etc.) wherein the conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e., which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte. | 2011-04-21 |
20110091915 | IgA Nephropathy Testing Method and Test Kit - There is provided a renal disease testing method comprising a complex detection step of detecting a complex of human uromodulin and human IgA in a sample derived from urine collected from a subject. It is preferred that the renal disease testing method of the invention further comprises a determination step of assessing the whether the renal disease is IgA nephropathy based on the ratio of the amount of the complex detected in the complex detection step to the amount of urinary proteins in the sample. The renal disease testing method of the invention has good detection sensitivity and specificity, and can conveniently and safely assess the existence of a renal disease (preferably, IgA nephropathy). | 2011-04-21 |
20110091916 | LUCIFERIN-LUCIFERASE BASED MICRODEVICE FOR BIOSENSING - A method and apparatus for determining the concentration of one or more microbes in a sample is provided. This method involves filtering a sample through a filter inside a sample tube to retain the one or more microbes on the filter. The resulting filtrate, which contains or produces adenosine triphosphate, is passed through the sample tube and enters the reporter region. In the reporter region, the adenosine triphosphate in the filtrate comes in contact with a transparent porous matrix, which includes a luciferin-luciferase complex. The adenosine triphosphate interacts with the luciferin-luciferase complex to provide light response, which is measured by a detector. The light response is compared with a calibration curve to determine the total concentration of one or more microbes in a sample. | 2011-04-21 |
20110091917 | METHOD OF MEASURING LIPID IN SPECIFIC LIPOPROTEIN - A method of measuring a lipid in a specific lipoprotein characterized by using a polycyclic polyoxyalkylene derivative at least in the step of determining the specificity of the measurement of the target lipid. | 2011-04-21 |
20110091918 | HETEROGENEOUS COAGULATION TEST - Within the field of coagulation diagnostics, in heterogeneous methods for determining the activity of blood coagulation factors and also in heterogeneous methods for determining anticoagulants which inhibit the activity of blood coagulation factors, a sample is contacted with a cleavable substrate, and the amount of uncleaved substrate is subsequently determined. | 2011-04-21 |
20110091919 | pH-INSENSITIVE GLUCOSE INDICATOR PROTEIN - The present invention encompasses a glucose indicator protein, a biosensor comprising one or more glucose indicator proteins, and methods of use thereof. | 2011-04-21 |
20110091920 | METHOD OF DIAGNOSING A CLINICAL CONDITION BY DETECTION OF A PAPP-A/proMBP COMPLEX - The present invention provides a method of diagnosing Down's syndrome, acute coronary syndrome or pre-eclampsia, or a predisposition to any of them, by a method comprising measuring the level of the human PAPP-A/proMBP complex in a body fluid sample. | 2011-04-21 |
20110091921 | NOVEL 12 ALPHA-HYDROXYSTEROID DEHYDROGENASES, PRODUCTION AND USE THEREOF - The invention relates to 12 α-hydroxysteroid dehydrogenases, nucleic acid sequences coding for the same, expression cassettes and vectors, recombinant microorganisms containing the corresponding coding nucleic acid sequences, a method for producing said 12 α-hydroxysteroid dehydrogenases, a method for enzymatic oxidation of 12 α-hydroxysteroids using said enzyme, a method for enzymatic reduction of 12-ketosteroids using said enzyme, a method for qualitative or quantitative determination of 12-ketosteroids and/or 12α-hydroxysteroids using said 12α-hydroxysteroid dehydrogenases and a method for production of ursodesoxycholic acid, comprising the enzyme-catalysed cholic acid oxidation using said 12 α-hydroxysteroid dehydrogenases. | 2011-04-21 |
20110091922 | Bio-Matrix Stretcher - Embodiments provide techniques for measuring and characterizing the dynamics of cell traction forces. Tunable elastic gel substrates can be disposed in multi-well plates. The gels can be of a uniform predetermined thickness. A multi-well plate can be loaded with gels of different shear moduli. An array of punch indenters can be attached to a loading platen such that the each indenter is aligned to a gel substrate. The indenters can apply tensile or compressive strains to the gel substrates. The magnitude, duration, and frequency of the strain can be controlled by a motor assembly coupled to a control system. The apparatus can be disposed in an incubator for long term cell culture experiments. The cell culture can be observed while a strain is applied. A ring-shaped indenter can be mounted on a microscope, coaxial to the objective lens, and lowered by a calibrated amount onto the underlying gel. | 2011-04-21 |
20110091923 | Compact Optical Reader System - A method and optical reader system for label-independent detection as defined herein. The reader system includes: a launch beam; a first lens; a receptacle for receiving at least one optical biosensor article, the article having a mask on one face, and the mask having at least one aperture there through for receiving and transmitting radiation from the collimated launch beam; an angular separator; and an imager to record the image of the optical biosensor article. | 2011-04-21 |
20110091924 | Method of evaluating cancer type - According to the method of evaluating cancer type of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and the cancer type in the subject is evaluated based on the concentration value of at least one of Glu, ABA, Val, Met, Pro, Phe, Thr, Ile, Leu, and His contained in the measured amino acid concentration data of the subject. | 2011-04-21 |
20110091925 | Processing of nanoparticles - Ligand-capped nanoparticles are dispersed in an organic solvent. There is then phase transfer of the nanoparticles introducing into the organic solvent an aqueous solution of polymer surfactant dissolved in water. The organic solvent and the aqueous solution are then mixed until the polymer forms micelles which encapsulate the nanoparticles in assemblies. The resultant nanoparticle assemblies in an aqueous phase may be used for any of a range of desired applications. It has been found that the assembly size can be tuned by control of any or a combination of method parameters such as concentration of polymer surfactant, and/or temperature of the phase change reaction, and/or rate of mixing, such as rotational rate of stirring. The nanoparticle assemblies find particular application as fluorescent biomarkers. | 2011-04-21 |
20110091926 | PERFUSABLE BIOREACTOR FOR THE PRODUCTION OF HUMAN OR ANIMAL TISSUES - A perfusable bioreactor is used for the production of human tissues, animal tissues or tissue equivalents. Their production is based on a structure cultivated in the interior, the interior being enclosed by an envelope and containing at least one inlet and one outlet for a liquid nutrient medium. Accordingly, the bioreactor can be connected to a unit for producing a perfusion pressure of the nutrient medium. This tissue replacement is particularly suitable for use in clinical/therapeutical applications. | 2011-04-21 |
20110091927 | MOTOR NEURONS DEVELOPED FROM STEM CELLS - The present invention provides a method for directing differentiation of neural progenitors with a caudal and ventral specification into motor neurons comprising culturing neural progenitors in a culturing medium comprising a basic medium supplemented by at least one inhibitor of the Notch signaling pathway whereby said neural progenitors differentiate into postmitotic motor neurons. The resulting motor neurons may be used for drug development, as carriers, e.g. for gene therapy of protein delivery as well as for transplantation for the purpose of treating a motor neuron disease. | 2011-04-21 |
20110091928 | Agent for Recruitment of Bone-Marrow-Derived Pluripotent Stem Cell Into Peripheral Circulation - The present invention for the first time demonstrated that: | 2011-04-21 |
20110091929 | MEANS AND METHODS FOR ASSESSING LIVER ENZYME INDUCTION - The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction. Finally, the present invention pertains to the use of a group of analytes or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing the pro-pathological effect of liver enzyme induction in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver enzyme induction markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, galactose, 3- and 5-Methoxysphingosine, Cholesterol, Threonic acid, 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, Glycerol, Glycerophosphate, Dodecanol, myo-Inositol-2-monophosphate. | 2011-04-21 |
20110091930 | WELL-BASED FLOW SYSTEM FOR CELL CULTURE - A well-based flow system for cell culture is described which provides for flow of culture containing compounds for drug screening to be exposed to cells seeded on a membrane. The flow of medium may be planar or radial and means are provided for the removal of waste media through fluid outlets in fluid communication with the assay well plates through conduits. Methods of using the system for cell culture and drug toxicity screening are also provided including coculturing cells such as hepatocytes, stem cells, fibroblasts and smooth muscle cells and selectively exposing cells to test compounds. | 2011-04-21 |
20110091931 | Methods and Kits for Determining Oxygen Free Radical (OFR) Levels in Animal and Human Tissues as a Prognostic Marker for Cancer and Other Pathophysiologies - Described herein are methods and techniques for the determination of reactive oxygen species in resected animal and human tissues. Also described herein are methods for determining the efficacy of anti-oxidant, oxidative stress modulatory, or anti-inflammatory drug chemoprevention or chemotherapy for the prevention and/or therapy of chronically inflamed and/or progressive cancers and pathophysiologies. | 2011-04-21 |
20110091932 | Automated extraction and purification of samples using optical tweezers - An apparatus and method for purifying a forensic sample using an automated extraction and purification system includes optical tweezers; an input channel through which the sample is introduced; a chamber which receives the sample from the input channel; a collection channel through which selected particles of the sample are removed; and an output through which unselected particles of the sample are removed. At least one buffer input channel is provided. The input channel may allow sedimentation of the sample into the chamber by gravity. In another arrangement, the system includes an optical trapping system; a first channel through which the sample is introduced; a second channel through which buffer is introduced; wherein the optical tweezers are used to move selected particles of the sample from the first channel to the second channel. The selected particles may be sperm. The optical tweezers preferably utilize holographic optical trapping. | 2011-04-21 |
20110091933 | METHOD OF TREATING MICROORGANISM - A method of treating microorganisms which can solve conventional problems in a treatment of counting the number of microorganisms, a proliferation treatment of microorganisms and a purification treatment of microorganisms is provided. A method of treating microorganisms in which any one of the intended treatments of a treatment of counting the number of microorganisms, a proliferation treatment of microorganisms and a purification treatment of microorganisms is carried out, the method including, before carrying out an intended treatment step, a pretreatment step of packing a predetermined amount of a sample solution containing the microorganisms in a closed container 22 and subjecting the closed container to high speed oscillating motion. | 2011-04-21 |
20110091934 | Laccase Variants - The present invention relates to variants of a parent laccase. The present invention also relates to polynucleotides encoding the variant laccases and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes. | 2011-04-21 |
20110091935 | PRODUCTION OF RECOMBINANT PROTEINS IN SYNTHETIC MEDIUM - The invention relates to a method for the production of recombinant proteins by eucaryotic cells in synthetic culture media, wherein said eucaryotic cells are transfected with a composition comprising a synthetic transfection reagent based on a polyhydroxylated polyalkyleneimine. | 2011-04-21 |
20110091936 | PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA - The present invention relates generally to glutamine-free cell culture media supplemented with arginine. The invention further concerns the production of recombinant proteins, such as antibodies, in arginine-supplemented glutamine-free mammalian cell culture. | 2011-04-21 |
20110091937 | Method of Producing Clostridium Botulinum Toxin Using Media Containing Plant-Derived Components and Flexible Closed Container - Provided are a method of producing | 2011-04-21 |
20110091938 | Starch Hydrolysis - Disclosed is a method for hydrolyzing starch. The starch is subjected to hydrolysis in the presence of a neutral calcium salt, the hydrolysis being conducted at a pH ranging from about 5.0 to about 5.5. The calcium salt may be a non-toxic and label-friendly salt such as calcium sulfate, calcium chloride or calcium phosphate, preferably naturally existing salts. The enzymatically catalyzed hydrolysis may be quenched using an organic acid, such as citric acid, preferably an acid that exists in nature, or with heat. Certain processing and product quality advantages may be realized via the disclosed method. The method may provide a variety of hydrolyzed products, including maltodextrins, syrup solids, and the like. | 2011-04-21 |
20110091939 | Methods and Compositions for Removing Specific Target Nucleic Acids - The present invention provides methods, compositions and kits for removing specific target nucleic acid(s) from a nucleic acid sample. In particular, present invention provides a blocker oligonucleotide to prevent the target nucleic acid from binding to captor oligonucleotides, thus removing the target nucleic acid from a captor-binding nucleic acid pool. The present invention can be applied, for example, to remove high abundance mRNAs/cDNAs in high throughput nucleic acid sequencing. | 2011-04-21 |
20110091940 | HIGHLY DISORDERED CELLULOSE - Disclosed are methods and systems for treating cellulose to make it more accessible for enzymatic or chemical modification. The invention includes treating cellulose with an alkali in an alcohol/water co-solvent system. The treatment decrystallizes or deaggregates the cellulosic material. The methods and systems increase the efficiency of enzymatic or chemical modifications of cellulose for use as biofuels or cellulose derivatives. | 2011-04-21 |
20110091941 | Process For Producing Fermentation Products - The invention relates to processes for hydrolyzing lignocellulose-containing material. The invention also relates to processes of producing fermentation products including a hydrolysis process of the invention. | 2011-04-21 |
20110091942 | PROCESS FOR PRODUCTION OF CIS-4-HYDROXY-L-PROLINE - Development of a method of economically and efficiently producing cis-4-hydroxy-L-proline. The present invention provides L-proline cis-4-hydroxylase. This enzyme may be derived from | 2011-04-21 |
20110091943 | SEMI-CONTINUOUS AND CONTINUOUS ENZYMATIC HYDROLYSIS PROCESS - The present invention relates to an semi-continuous or continuous process for the regioselective enzymatic hydrolysis of alcohol groups protected e.g. as esters or amino-acid esters or phosphate groups The process of the present invention is useful for instance for the selective enzymatic hydrolysis of pyranosides or furanosides having more than one hydrolysable groups. | 2011-04-21 |
20110091944 | ADIPATE (ESTER OR THIOESTER) SYNTHESIS - The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention relates to a method for preparing 6-amino caproic acid (6-ACA), a method for preparing 5-formyl valeric acid (5-FVA), and a method for preparing caprolactam. Further, the invention relates to a host cell for use in a method according to the invention. | 2011-04-21 |
20110091946 | Enzymatic Process for Obtaining a Fatty Ester - The aim of the present invention is to obtain fatty esters from fatty acids derived from vegetable oils and butters, through an enzymatic process, so that said esters can act as emollients, emulsifiers and co-emulsifiers with differentiated performance, having high spreadability and slidability compared to the prior-art products. More specifically, the present invention relates to an enzymatic process for obtaining a fatty ester, comprising: a) obtaining a fatty acid through the enzymatic hydrolysis (saponification) of vegetable oils and butters selected from cupuagu butter, sapucainha butter, ucu{acute over (υ)}ba butter, murumuru butter, palm olein, pataua oil, tucuma oil, inaja oil, passion fruit oil, pequi oil and nasturtium oil; b) reacting the fatty acid with a fatty alcohol selected from capric alcohol, caprylic alcohol, isoamylic alcohol, lauric alcohol, myristic alcohol, lorol (70:30 mixture of lauric alcohol and myristic alcohol), cetyl alcohol, stearyl alcohol, cetostearyl alcohol (70:30 mixture of cetyl alcohol and stearyl alcohol), sorbitol, sorbitan, glycerin, polyglycerin, other polyols and mixture thereof, in the presence of an enzyme, in at least one reactor, at a temperature of from 40 to 80 QC; c) stirring the reaction solution; d) removing moisture from the reaction medium; e) vacuum filtering said solution to obtain the fatty ester. The fatty esters obtained through the process of the present invention can be used in the preparation of cosmetic compositions. | 2011-04-21 |
20110091947 | High-Purity Purification Method for Omega-3 Highly Unsaturated Fatty Acids - The present invention relates a high-purity purification method for omega-3 highly unsaturated fatty acids. More specifically, it relates to a high-purity purification method for omega-3 highly unsaturated fatty acids which is both environmentally friendly and easy to implement and comprises the steps of: a) preparing a fatty acid ethyl ester (FAEE) by ethanolysis of a natural oil or fat, using ethanol, in the presence of an enzyme catalyst extracted from at least one microorganism selected from the group consisting of | 2011-04-21 |
20110091948 | MICROORGANISM CAPABLE OF PRODUCING IMPROVED POLYHYDROXYALKANOATE AND METHOD OF PRODUCING POLYHYDROXYALKANOATE BY USING THE SAME - The present invention relates to a microorganism which is capable of producing a polyhydroxyalkanoate (PHA) and satisfies the requirements: (1) expression of a phbA gene is repressed or a catalytic activity of an enzyme encoded by the gene is repressed; (2) expression of a bktB gene is enhanced or a catalytic activity of an enzyme encoded by the gene is increased; and (3) a polyhydroxyalkanoate synthase gene and a crotonyl-CoA reductase gene are introduced thereinto. Culture of this microorganism enables efficient production of P(3HB-co-3HH), which is a PHA having excellent flexibility and being applied to a variety of applications, with an inexpensive carbon source. | 2011-04-21 |
20110091949 | Process for Producing D-Mannitol - High concentration of free cells of heterofermentative lactic acid bacteria (LAB) in a resting or slowly growing state are used to convert fructose into mannitol. Efficient volumetric mannitol productivities and mannitol yields from fructose are achieved in a process applying cell-recycle, continuous stirred tank reactor and/or circulation techniques with native LAB cells or with LAB cells with inactivated fructokinase gene(s). Mannitol is recovered in high yield and purity with the aid of evaporation and cooling crystallization. | 2011-04-21 |
20110091950 | POLYPEPTIDES HAVING ALPHA-GLUCURONIDASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to isolated polypeptides having alpha-glucuronidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2011-04-21 |