16th week of 2013 patent applcation highlights part 45 |
Patent application number | Title | Published |
20130096248 | TIRE TREAD FOR HIGH PERFORMANCE TIRES - Tires having treads constructed of a material that is based upon a cross-linkable rubber composition, the rubber composition in some embodiments including between 25 phr and 5.0 phr of a butadiene rubber and between 50 phr and 75 phr of a styrene-butadiene rubber (SBR). wherein the butadiene portion of the SBR has at least 50% vinyl content. The rubber composition may further include between 25 phr and 60 phr of a plasticizing resin having a glass transition temperature Tg of between 30° C. and 120° C. and between 25 phr 60 phr of a vegetable oil. The ratio of the vegetable oil phr to the high Tg resin phr may, in some embodiments, be between 0.75 and 3. Further, such rubber compositions may also be reinforced with between 100 phr and 200 phr of a silica filler. | 2013-04-18 |
20130096249 | NEW ORGANOSILICON COMPOUND, THERMOSETTING RESIN COMPOSITION CONTAINING THE ORGANOSILICON COMPOUND, HARDENING RESIN AND ENCAPSULATION MATERIAL FOR OPTICAL SEMICONDUCTOR - A solution is a liquid organosilicon compound represented by general formula (1) as described below: | 2013-04-18 |
20130096250 | PROCESS FOR IMPROVING HIDING EFFICIENCY IN PIGMENT PAINTS - The present invention relates to a process comprising the steps of a) contacting an aqueous dispersion of a TiO | 2013-04-18 |
20130096251 | CURABLE SILYL POLYMERS - Embodiments of the invention relate to crosslinkable silyl group-containing polymers and methods of producing them. In one embodiment a method of producing a silyl polymer is provided. The method includes reacting at least one natural oil based polyol with at least one isocyanate to form at least one prepolymer having at least one NCO group. The at least one natural oil based polyol includes the reaction product of hydroxymethylated fatty acids or esters thereof and at least one polyol initiator. The prepolymer having at least one NCO group is reacted with at least one amino functional alkoxy silane to form the silyl polymer, such that the silyl polymer includes at least one crosslinkable silyl group, at least one urethane group, and at least one urea group in each molecule. | 2013-04-18 |
20130096252 | TIN FREE SILYL-TERMINATED POLYMERS - Embodiments of the invention provide for methods of producing a composition comprising a crosslinkable silane-terminated polymer having at least one crosslinkable silyl group in each molecule. The method comprises providing a polymer having at least one unsaturated group and at least one alcoholic hydroxyl group in each molecule, adding to the polymer a compound having a hydrogen-silicon bond and a crosslinkable silyl group in each molecule and a hydrosilylation catalyst to thereby carry out a hydrosilylation reaction to form a composition comprising hydrosilylated polyoxyalkylene polymers, reacting the hydrosilylated polyoxyalkylene polymers with at least one isocyanate in the presence of a first tin-free catalyst to form an isocyanate reacted hydrosilylated polymer, and optionally reacting the isocyanate reacted hydrosilylated polymer with a polyol having a nominal functionality of at least 2 to form a polyol reacted crosslinkable silane-terminated polymer. | 2013-04-18 |
20130096253 | FIXING MATERIAL COMPRISING SILANE COMPOUND POLYMER AND PHOTONIC DEVICE SEALED BODY - A fixing material includes a silane compound polymer as the main component, the silane compound polymer being produced by condensing a silane compound mixture that includes at least one silane compound (1) shown by the following formula (1): R | 2013-04-18 |
20130096254 | PROCESS FOR THERMALLY STABLE OLEOPHOBIC LOW ADHESION COATING FOR INKJET PRINTHEAD FRONT FACE - A coating for an ink jet printhead front face, wherein the coating comprises an oleophobic low adhesion coating having high thermal stability as indicated by less than about 15 percent weight loss when heated to up to 300° C., and wherein a drop of ultra-violet (UV) gel ink or a drop of solid ink exhibits a contact angle of greater than about 45° and sliding angle of less than about 30° with a surface of the coating, wherein the coating maintains the contact angle and sliding angle after the coating has been exposed to a temperature of at least 200° C. for at least 30 minutes. | 2013-04-18 |
20130096255 | PROCESS FOR THE PREPARATION OF LOW-VISCOSITY, WATER-EMULSIFIABLE ALLOPHANATES WITH RADIATION-CURABLE GROUPS - The present invention relates to a process for the preparation of low-viscosity polyisocyanate reaction products which contain allophanate groups, can be readily emulsified in water and contain activated groups which react, by polymerization, with ethylenically unsaturated compounds under the action of actinic radiation. The present invention furthermore relates to the products which can be prepared by the process according to the invention and their use. | 2013-04-18 |
20130096256 | NOVEL CROSS-LINKER - Disclosed are novel cross-linkable end-cappers for oligo-and polyimides. End-capped oligo-and polyimides comprising such an end-capper may be cured at a lower temperature compared to oligo-and polyimides end-capped with PEPA. | 2013-04-18 |
20130096257 | SILICONE RELEASE COATING COMPOSITION OF CONDENSATION REACTION CURING TYPE - Disclosed herein is a silicone release coating composition of condensation reaction curing type including: (A) an organopolysiloxane having at least two silanol groups in one molecule; (B) (B-1) an organohydrogenpolysiloxane having at least three SiH groups in one molecule, and/or (B-2) an organopolysiloxane having at least three hydrolyzable groups directly bonded to a silicon atom in one molecule; (C) a compound of metal selected from Mg, Al, Ti, Cr, Fe, Co, Ni, Cu, Zn, Zr, W, and Bi, which functions as a condensation reaction catalyst; and (D) (D-1) a cocatalyst of an organic compound having a bond between a nitrogen atom and an oxygen atom and/or a bond between a nitrogen atom and a sulfur atom through 1 to 3 carbon atoms, or (D-2) a cocatalyst of an organic compound functioning as an oxygen multidentate ligand. | 2013-04-18 |
20130096258 | POLYMER CONJUGATES OF GLP-1 - Conjugates of a GLP-1 moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-1 polymer conjugate may include a GLP-1 moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-1 polymer conjugate may include a GLP-1 moiety covalently attached to a water-soluble polymer, wherein the GLP-1 moiety possesses an N-methyl substituent. | 2013-04-18 |
20130096259 | POLYMER COMPOSITIONS - The invention provides a composition comprising at least the following: A) a thermoplastic polyurethane; B) an elastomer; C) a polydiene-based polyurethane or a polydiol-based polyurethane; D) a polyoctenamer; and E) a resin selected from the group consisting of the following: i) an indene-coumarone resin, ii) an aromatic hydrocarbon resin, and iii) an aliphatically modified aromatic hydrocarbon resin. | 2013-04-18 |
20130096260 | RUBBER COMPOSITION CONTAINING TREATED SILICA AND PRODUCTS WITH COMPONENT THEREOF - The invention relates to rubber compositions containing a treated silica, particularly sulfur cured rubber compositions, and articles of manufacture having a component thereof such as, for example tires. The invention particularly relates to synthetic amorphous silica, particularly a precipitated silica, treated with a combination of allylsilane and dialkylsilane. | 2013-04-18 |
20130096261 | Cross-Linked Polyolefin Composition - A cross-linked composition, obtained by cross-linking polyolefin composition comprising, all percentages being by weight:
| 2013-04-18 |
20130096262 | ACTIVE POLYMERIC FILTERS - A compound includes a polymer where the polymer includes a pendant dioxirane moiety. Cost-effective, facilitated generation of a polymer including a pendant dioxirane moiety allows for the compound to be disposable or be easily recycled. The compound can be used in air purification and liquid purification to not only remove particulate matter, but also to destroy microorganisms and remove volatile organic compounds. | 2013-04-18 |
20130096263 | CROSSLINKED COMPOSITIONS AND ARTICLES PREPARED THEREFROM - The invention provides a crosslinked composition formed by thermally treating a composition comprising at least the following: A) an ethylene-based polymer that has a density less than, or equal to, 0.910 g/cc; B) an olefin-based polymer that has a melt viscosity less than, or equal to, 20,000 cP, at 350° F.; and C) a crosslinking agent. | 2013-04-18 |
20130096264 | POLYMERS FUNCTIONALIZED WITH NITROSO COMPOUNDS - A method for preparing a functionalized polymer, the method comprising the steps of: (i) polymerizing monomer with a coordination catalyst to form a reactive polymer; and (ii) reacting the reactive polymer with a nitroso compound. | 2013-04-18 |
20130096265 | MIKTOPOLYMER COMPOSITIONS - The present invention provides a block copolymer composition and method of making the same having the structures (A | 2013-04-18 |
20130096266 | BIMODAL POLYETHYLENE COMPOSITION AND ARTICLES MADE THEREFROM - The invention relates to a polyethylene composition with a bimodal molecular weight distribution and articles made therefrom, such as high topload blow moldings and transmission and distribution pipes. The composition comprises a low-molecular-weight (LMW) ethylene homopolymer component and a homogeneous, high-molecular-weight (HMW) ethylene interpolymer component, wherein the LMW component is characterized as having a molecular weight distribution, MWD | 2013-04-18 |
20130096267 | PROCESS FOR PRODUCING FUNCTIONALIZED POLYMERS - A method for preparing a functionalized polymer, the method comprising the steps of (a) polymerizing monomer in the presence of a coordination catalyst to form a polymer, (b) inhibiting said step of polymerizing with a Lewis base, and (c) reacting the polymer with a functionalizing agent. | 2013-04-18 |
20130096268 | MONODISPERSE POLYMERS CONTAINING (ALKYL)ACRYLIC ACID MOIETIES, PRECURSORS AND METHODS FOR MAKING THEM AND THEIR APPLICATIONS - This invention relates to monodisperse or nearly monodisperse (co)polymers containing acrylic or (α-substituted)acrylic acid moieties, polymeric precursors thereof as well as methods for making them by at least partial hydrolysis of said polymeric precursors. The invention also relates to compositions comprising such (co)polymers optionally in combination with polymer processing additives for use in various fields of technology including imaging applications. | 2013-04-18 |
20130096269 | ETHYLENE-BASED TERPOLYMER HAVING HIGH ELASTICITY AND PREPARATION METHOD THEREOF - The present invention relates to an ethylene-based terpolymer having high elasticity and a preparation method thereof, and more particularly, to a highly elastic, ethylene-based terpolymer, which comprises a specific molar ratio of a ethylene unit, a C | 2013-04-18 |
20130096270 | PORPHYRIN COPOLYMER CONTAINING THIENOTHIADIAZOLE UNITS, PREPARATION METHOD AND USES THEREOF - A porphyrin copolymer containing thienothiadiazole units, preparation method and uses thereof are disclosed. The copolymer has the structural formula (I), wherein: R | 2013-04-18 |
20130096271 | SALALEN LIGANDS AND ORGANOMETALLIC COMPLEXES - Use of homogeneous catalytic systems which include as a pre-catalyst a complex of a Group IV metal and a salalen ligand in the polymerization of alpha-olefins, is disclosed. The alpha-olefin polymers obtained are characterized by controlled levels of tacticity. Also disclosed are novel salalen ligands and novel complexes thereof with Group IV metals. | 2013-04-18 |
20130096272 | PROCESS FOR PREPARING A (METH)ACRYLATE COPOLYMER CONTAINING TERTIARY AMINO GROUPS BY FREE-RADICAL POLYMERIZATION IN SOLUTION - The invention relates to a process for preparing a (meth)acrylate copolymer containing quaternary ammonium groups from a monomer mixture selected from: (a) 80 to 99% by weight of a C1-C4-alkyl ester of acrylic acid or methacrylic acid; and (b) 20 to 1% by weight of an alkyl ester of acrylic acid or methacrylic acid with a quaternary ammonium group in the alkyl radical; and (c) 0 to 10% of further copolymerizable vinyl monomers whereby one or more polymerization initiators, optionally one or more molecular weight regulators and one or more solvents or of a solvent mixture are added to the monomer mixture to give a polymerization mixture, which is polymerized at temperatures from 30 to 120 C over a period of 2 to 24 hours, where the polymerization mixture is polymerized to a polymerization syrup with a conversion of the monomers to the copolymer of at least 99% by weight, where the polymerization syrup is subsequently degassed by distillation or by extrusion and the degassed polymerization syrup is further comminuted to a copolymer preparation in the form of a granulate or powder and where the copolymer preparation is characterized by a molecular weight (Mw) of 25.000 to 50.000, a polydispersity index of 2.0 to 3.0 and a residual solvent concentration of less than 10.000 ppm by weight. | 2013-04-18 |
20130096273 | ULTRAVIOLET LIGHT ABSORBING MATERIALS FOR INTRAOCULAR LENS AND USES THEREOF - A method for reducing the transmittance of ultraviolet radiation through an intraocular lens to 10% or less at 370 mm Additionally, a method for preventing the transmittance of at least 90% of ultraviolet radiation at 370 nm through a foldable intraocular lens comprising: (a) incorporating a monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety into at least one polymer and (b) forming the polymer into a material suitable for use as an intraocular lens, wherein the monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety comprises 0.10 to 0.15 weight percent of the overall dry polymer. | 2013-04-18 |
20130096274 | SILYL-TERMINATED POLYMERS - Embodiments of the invention provide for compositions including a crosslinkable silane-terminated polymer having at least one crosslinkable silyl group in each molecule. The crosslinkable silane-terminated polymer comprises a reaction product of at least a isocyanate capped hydrosilylated polymer and a polyol having a nominal functionality of at least 2 which is at least one of a polycarbonate polyol, a natural oil based polyol, a polyoxyalkyleneamine, a difunctional aromatic amine, a polybutyloxide polyether polyol, and a polytetramethylene glycol. | 2013-04-18 |
20130096275 | VANCOMYCIN B HYDROCHLORIDE CRYSTALLINE FORM 1 - Vancomycin B Hydrochloride Crystalline Form 1, compositions containing it and methods of prevention or treatment of bacterial infections using it are disclosed. | 2013-04-18 |
20130096276 | PROTEIN CAPABLE OF BINDING SPECIFICALLY TO IMMUNOGLOBULIN, AND IMMUNOGLOBULIN-BINDING AFFINITY LIGAND - An object of the present invention is to create a novel engineered Protein A ligand having better antibody dissociation properties in the acidic condition compared with known engineered Protein A ligands. The present invention provides a protein having an affinity for an immunoglobulin, including an amino acid sequence obtained by introducing, into an amino acid sequence derived from any of E, D, A, B and C domains of Protein A, at least one amino acid substitution at any one or more of amino acid residues corresponding to positions 31 to 37 of the A, B and C domains (positions 29 to 35 of the E domain, positions 34 to 40 of the D domain), which are conserved in all the domains, the protein having a lower affinity for an Fab region of an immunoglobulin than a protein having the amino acid sequence before introduction of the substitution. | 2013-04-18 |
20130096277 | PROCESSES AND INTERMEDIATES - A process for preparing enantioselectively a compound of formula I-1a or I-1b: | 2013-04-18 |
20130096278 | THIOSULFONATE COMPOUND, REVERSIBLE CATIONIZATION AGENT FOR PROTEIN AND/OR PEPTIDE, AND METHOD FOR SOLUBILIZATION - The object of the present invention is to provide a novel thiosulfonate compound, a reversible cationization agent for protein and/or peptide, which can reversibly cationize a wider range of proteins and peptides with high stability of quality and accuracy and which are useful for a high degree of purification and recovery, as well as, a method for solubilization for protein and/or peptide using the agent. | 2013-04-18 |
20130096279 | PROCESS FOR THE PURIFICATION OF A GROWTH FACTOR PROTEIN - A process of purifying a Growth Factor Protein in a purification sequence employing chromatography characterized in that
| 2013-04-18 |
20130096280 | METHODS AND COMPOSITION FOR SECRETION OF HETEROLOGOUS POLYPEPTIDES - The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns recombinant polypeptides and uses thereof. | 2013-04-18 |
20130096281 | METHODS AND COMPOSITIONS FOR DISPLAYING A POLYPEPTIDE ON A YEAST CELL SURFACE - Provided herein are methods and compositions for use in displaying a polypeptide (e.g., an antibody polypeptide or an antibody polypeptide fragment) on the surface of a yeast cell. Exemplary yeast that can be used in conjunction with various methods and compositions disclosed herein include those of the genus | 2013-04-18 |
20130096282 | THERAPEUTIC ANTIBODIES AGAINST FLAGELLATED PSEUDOMONAS AERUGINOSA - Improved antibodies are provided selected from human, dual-specific, chimeric or humanized antibodies, wherein said human chimeric and humanized antibodies specifically bind to flagellin type A or type B of | 2013-04-18 |
20130096283 | Method of Supplementing Culture Media to Prevent Undesirable Amino Acid Substitutions - The present invention relates to methods of reducing substitution of amino acids during the production of polypeptides of interest in mammalian cells. By varying the concentration of amino acids in the culture medium, heterogeneity of the polypeptide's amino acid sequence is decreased, leading to higher yields of functional protein. | 2013-04-18 |
20130096284 | METHOD FOR PURIFYING PROTEIN USING AMINO ACID - In large-scale purification of proteins such as antibodies, an economic high-purity purification method is required. The present invention relates to a method for purifying a protein, including one or more chromatographic processes, in which an amino acid; or a dipeptide, an oligopeptide, or a polyamino acid thereof is included in a buffer solution used in at least one chromatographic processes (equilibration buffer, wash buffer, and elution buffer), thereby purifying a high-purity protein with a very small quantity of the impurity (e.g., polymers or host cell proteins). | 2013-04-18 |
20130096285 | HIGHLY EFFICIENT LIGNIN-BASED WATER-REDUCING AGENT WITH HIGH DEGREE OF SULFONATION AND HIGH MOLECULAR WEIGHT, AND PREPARATION METHOD THEREOF - This invention discloses a high-performance lignin-based water reducer with high degree of sulfonation and high molecular weight and its preparation method. This water reducer exhibits an excellent water-reducing performance, its water-reducing rate of this lignin-based water reducer reaches 25% at a dosage of 0.70 wt %, which is higher than that of the naphthalene-based water reducer and the sulfonated lignin water reducer prepared by oxidation and sulfonation of alkali lignin, and 28-days compressive strength ratio of the concrete with this water reducer to the concrete without this water reducer is up to 150:100. Furthermore, the water reducer of present invention will not be crystallized in winter, and the concrete iron won't be corroded. The water reducer of the present invention makes the concretes having a low bleeding rate, excellent properties of workability, anti-freeze and anti-carbonization. | 2013-04-18 |
20130096286 | SYNTHESIS OF AZO BONDED IMMUNOREGULATORY COMPOUNDS - Methods are disclosed for preparing compounds of Formula I: | 2013-04-18 |
20130096287 | Restricted Immunoglobulin Heavy Chain Mice - Mice having a restricted immunoglobulin heavy chain locus are provided, wherein the locus is characterized by a single polymorphic human V | 2013-04-18 |
20130096288 | siRNA conjugate and preparation method thereof - Provided are an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalently bonding siRNA and a polymeric compound for improving the in vivo stability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the in vivo stability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relative low concentration. Therefore, the conjugate can advantageously be used as not only an siRNA treatment tool for cancers and other infectious disease, but also a novel type siRNA delivery system. | 2013-04-18 |
20130096289 | HYDROXYMETHYL SUBSTITUTED RNA OLIGONUCLEOTIDES AND RNA COMPLEXES - The present invention is directed to RNA oligonucleotides or complexes of RNA oligonucleotides, denoted herein together as RNA complexes, containing at least one, but optionally more that one, hydroxymethyl substituted nucleotide monomer(s). By a hydroxymethyl substituted nucleotide monomer is understood a nucleotide monomer containing a hydroxymethyl group (that may be unsubstituted, O-substituted for example with a conjugating group, or converted into an optionally substituted or conjugated aminomethyl group). This hydroxymethyl group is not partaking in formation of an internucleotide linkage and is not the hydroxymethyl group (containing the 5′-hydroxy group) of a natural RNA monomer. The RNA complexes of the invention may be useful for therapeutic applications, diagnostic applications or research applications. | 2013-04-18 |
20130096290 | SINGLE STRANDED EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION - The invention provides compositions and methods for reducing expression of a target gene in a cell, involving contacting a cell with an isolated double stranded nucleic acid (dsNA) in an amount effective to reduce expression of a target gene in a cell. The dsNAs of the invention possess a single stranded extension (in most embodiments, the single stranded extension comprises at least one modified nucleotide and/or phosphate back bone modification). Such single stranded extended Dicer-substrate siRNAs (DsiRNAs) were demonstrated to be effective RNA inhibitory agents compared to corresponding double stranded DsiRNAs. | 2013-04-18 |
20130096291 | New Method of Using N-Thio Compounds for Oligonucleotide Synthesis - A method for synthesizing an oligonucleotide which comprises using a sulfurizing agent of general formula (I) for sulfurizing at least one phosphorus internucleotide linkage of a precursor of the oligonucleotide, wherein R is an aryl group or a heteroaryl group, which is bonded to the S-atom through an annular carbon atom; and R | 2013-04-18 |
20130096292 | POLYNUCLEOTIDE CAPTURE MATERIALS, AND METHODS OF USING SAME - Methods for processing polynucleotide-containing biological samples, and materials for capturing polynucleotide molecules such as RNA and/or DNA from such samples. The RNA and/or DNA is captured by polyamindoamine (PAMAM (Generation 0)) bound to a surface, such as the surface of magnetic particles. The methods and materials have high efficiency of binding RNA and of DNA, and of release, and thereby permit quantitative determinations. | 2013-04-18 |
20130096293 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY - Methods and compositions relating to CDP-epothilone conjugates are described herein. | 2013-04-18 |
20130096294 | SIALIC ACID DERIVATIVES - An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy succinimide, to form an amide or hydrazide product. The product has a useful functionality, which allows it to be conjugated, for instance to proteins, drugs, drug delivery systems or the like. The process is of particular utility for derivatising amine groups introduced in sialic acid terminal groups of polysialic acids. | 2013-04-18 |
20130096295 | Maltoside and Phosphocholine Derivatives, Uses thereof and Methods of Preparing Artificial Lipid Structures Thereof - Disclosed are saccharide and phosphocholine derivatives. The derivatives include azide and alkyne derivatives which form one end of a variable length carbon chain. The opposite end of the variable length carbon chain is covalently linked to the saccharide or phosphocholine. The saccharide may be, for instance, a maltoside. The alkyne and azide derivatives of the saccharides and phosphocholine may be reacted together to form amphiphilic molecules useful in cellular membrane studies and applications. By adjusting the length of the carbon chain, the biochemical and biophysical properties of the resultant 1,4-disubstituted 1,2,3-triazole compounds may be custom tailored for the intended application. Resultant molecules may form micelles, bicelle, lipid bilayers and other like structures useful in the isolation and purification of membrane bound or membrane associated proteins and biochemical components. The saccharides and phosphocholine molecules may be alternatively substituted as desired to provide additional flexibility in designing the desired end product. | 2013-04-18 |
20130096296 | Methods for Synthesizing Acylated Cellulose Through Instillation of an Acidic Catalyst - Instilling an acidic catalyst to a reaction mixture can be beneficial during the acylation of cellulose. Methods described herein can comprise preparing a reaction mixture comprising an acylating agent and cellulose, instilling a catalyst comprising an acid to the reaction mixture, and reacting the cellulose with the acylating agent in the presence of the catalyst, thereby forming an acylated cellulose. | 2013-04-18 |
20130096297 | Methods for Synthesizing Acylated Cellulose Through Instillation of an Acidic Catalyst - Instilling an acidic catalyst to a reaction mixture can be beneficial during the acylation of cellulose. Methods described herein can comprise preparing a reaction mixture comprising an acylating agent and cellulose, instilling a catalyst comprising an acid to the reaction mixture at an overall catalyst loading level of about 1% or less by weight of the cellulose, and reacting the cellulose with the acylating agent in the presence of the catalyst, thereby forming an acylated cellulose. | 2013-04-18 |
20130096298 | Methods for Synthesizing Acylated Cellulose Through Instillation of an Acidic Catalyst - Instilling an acidic catalyst to a reaction mixture can be beneficial during the acylation of cellulose. Methods described herein can comprise preparing a reaction mixture comprising an acylating agent and cellulose, instilling a catalyst comprising an acid to the reaction mixture at an overall catalyst loading level of about 10% to about 20% by weight of the cellulose, and reacting the cellulose with the acylating agent in the presence of the catalyst, thereby forming an acylated cellulose. | 2013-04-18 |
20130096299 | NOVEL CEPHEM DERIVATIVE - Provided is a cephem compound which has a wide antimicrobial spectrum, and in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical composition comprising the same. | 2013-04-18 |
20130096300 | LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL - Cell permeable metal ion indicator compounds and methods of their use and synthesis are described. The compound comprises a metal chelating moiety (M | 2013-04-18 |
20130096301 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME - The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein. | 2013-04-18 |
20130096302 | PYRROLOPYRAZINES AND PYRAZOLOPYRAZINES USEFUL AS INHIBITORS OF PROTEIN KINASES - The present invention relates to compounds useful as inhibitors of Aurora protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. | 2013-04-18 |
20130096303 | PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES THEREOF - The present invention provides an improved process for preparing HMG-CoA reductase inhibitors such as rosuvastatin calcium, fluvastatin sodium, and pitavastatin calcium under a mild condition, using a novel amide-bond-containing compound having R | 2013-04-18 |
20130096304 | NILOTINIB HCL CRYSTALLINE FORMS - Crystalline forms of Nilotinib HCl are described. | 2013-04-18 |
20130096305 | DEUTERATED HIV ATTACHMENT INHIBITORS - Deuterated piperazine and piperidine HIV attachment inhibitor compounds are set forth. The present invention provides compounds of Formula I, the pharmaceutically acceptable salts and/or solvates (e.g., hydrates) thereof, their pharmaceutical formulations, and their use in patients suffering from or susceptible to a virus such as HIV. The compounds of Formula I, their pharmaceutically acceptable salts and/or solvates are effective antiviral agents, particularly as inhibitors of HIV. They are useful for the treatment of HIV and AIDS. | 2013-04-18 |
20130096306 | METHOD OF SYNTHESIS OF FERROQUINE BY CONVERGENT REDUCTIVE AMINATION - The invention relates to a method of synthesis of ferroquine of formula (F) or of its metabolite of formula (Fm): | 2013-04-18 |
20130096307 | METHOD OF SYNTHESIZING A COMPLEX [CO (NNS) 2] ACTIVE AGAINST THE MALARIA PARASITE PLASMODIUM - Metal complex of Cobalt (11) containing a dithio-based ligand have been synthesized and characterized by elemental analysis, mass spectrometry, Proton NMR and FT-IR spectrometry. A single crystal X-ray structure of the cadmium complex has been analyzed. The metal complex was subjected to biological tests on falcipain-2 (FP-2) and falcipain-3 (FP-3) cysteine protease enzymes from the malaria parasite Plasmodium falciparum. They were further tested in vitro against chloroquine resistant strain (W2). Whereas the potency of the metal complexes was weaker than the control regarding the FP-2 and FP-3, the potency of metal complexes was found to be exceedingly greater than the control when tested against the chloroquine resistant strain (W2) with a strength ratio of (0.5). This paper describes the synthesis, characterization and biological results of the said metal complex containing the deprotonated 3-[1-(2-pyridyl) ethylidene] hydrazinecarbodithioate ligand (FIG. | 2013-04-18 |
20130096308 | Method of Synthesizing the Complex [FE(NNS)2] Active Against the Malaria Parasite Plasmodium Falciparum - Metal complex of Iron (U) containing a dithio-based ligand have been synthesized and characterized by elemental analysis, mass spectrometry, Proton NMR and FT-ER spectrometry. A single crystal X-ray structure of the cadmium complex has been analyzed. The metal complex was subjected to biological tests on falcipain-2 (FP-2) and falcipain-3 (FP-3) cysteine protease enzymes from the malaria parasite | 2013-04-18 |
20130096309 | NOVEL RHODAMINE DYES AND CONJUGATES - The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products. | 2013-04-18 |
20130096310 | ISOQUINOLINE DERIVATIVE - A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a pharmaceutical. | 2013-04-18 |
20130096311 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED 1-ALKYLTETRAZOLYL OXIME DERIVATIVES - The present invention relates to a process for the preparation of 5-substituted 1-alkyltetrazolyl oxime derivatives. | 2013-04-18 |
20130096312 | Process for Preparing 4-hydroxypyridines - The present invention relates to a process for preparing 4-hydroxypyridines of formula I | 2013-04-18 |
20130096313 | METHODS FOR PREPARING RUTHENIUM CARBENE COMPLEX PRECURSORS AND RUTHENIUM VINYLCARBENE COMPLEXES - A method for preparing a ruthenium carbene complex precursor includes reacting a ruthenium refinery salt with a hydrogen halide to form a ruthenium intermediate, and reacting the ruthenium intermediate with an L-type ligand to form the ruthenium carbene complex precursor. A method for preparing a ruthenium vinylcarbene complex includes converting a ruthenium carbene complex precursor into a ruthenium hydrido halide complex, and reacting the ruthenium hydrido halide complex with a propargyl halide to form the ruthenium vinylcarbene complex. A method for preparing a ruthenium carbene complex includes converting a ruthenium carbene complex precursor into a ruthenium carbene complex having a structure (PR | 2013-04-18 |
20130096314 | METHODS FOR PREPARING RUTHENIUM CARBENE COMPLEX PRECURSORS AND RUTHENIUM CARBENE COMPLEXES - A method for preparing a ruthenium carbene complex precursor includes reacting a ruthenium refinery salt with a hydrogen halide to form a ruthenium intermediate, and reacting the ruthenium intermediate with an L-type ligand to form the ruthenium carbene complex precursor. A method for preparing a ruthenium vinylcarbene complex includes converting a ruthenium carbene complex precursor into a ruthenium hydrido halide complex, and reacting the ruthenium hydrido halide complex with a propargyl halide to form the ruthenium vinylcarbene complex. A method for preparing a ruthenium carbene complex includes converting a ruthenium carbene complex precursor into a ruthenium carbene complex having a structure (PR | 2013-04-18 |
20130096315 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 2013-04-18 |
20130096316 | Novel Method for Preparation of Bisnorcymerine and Salts Thereof - The present invention includes a novel method of preparing N | 2013-04-18 |
20130096317 | REDUCTION OF ALDEHYDES AND KETONES TO ALCOHOLS - The embodiments described herein provide a reduction of an aldehyde or a ketone, such as a Meerwein-Ponnorf-Verley (MPV) reaction of an aldehyde or ketone. In some embodiments, the reaction occurs in the presence of Al[OC(CH | 2013-04-18 |
20130096318 | MESO-BILIVERDIN COMPOSITIONS AND METHODS - Methods and materials for producing meso-biliverdin are provided where the methods include reacting phycocyanobilin with an amphoteric compound in a solvent to yield meso-biliverdin. | 2013-04-18 |
20130096319 | PROCESS FOR PREPARATION OF AMISULPRIDE - The present invention is related to a novel process for the preparation of amisulpride (I) which involves: methylation of 4-amino-salicylic-acid (VI) with dimethyl sulphate and base, optionally in presence of TBAB to obtain 4-amino-2-methoxy methyl benzoate (VII) and (ii) oxidation of 4-amino-2-methoxy-5-ethyl thio benzoic acid (IX) or 4-amino-2-methoxy-5-ethyl thio methyl benzoate (X) with oxidizing agent in the presence of sodium tungstate or ammonium molybdate to give 2-methoxy-4-amino-5-ethyl-sulfonyl benzoic acid (IV) or 2-methoxy-4-amino-5-ethyl-sulfonyl methyl benzoate (XI) respectively. | 2013-04-18 |
20130096320 | ORGANIC SEMICONDUCTIVE MATERIAL PRECURSOR CONTAINING DITHIENOBENZODITHIOPHENE DERIVATIVE, INK, INSULATING MEMBER, CHARGE-TRANSPORTING MEMBER, AND ORGANIC ELECTRONIC DEVICE - An organic semiconductive material precursor containing a dithienobenzodithiophene derivative expressed by General Formula I: in General Formula I, X and Y represent groups bonded together, upon application of external stimulus, to form X—Y which is eliminated from the compound expressed by General Formula I; R | 2013-04-18 |
20130096321 | CRYSTALLINE ROTIGOTINE BASE AND PREPARATION PROCESS THEREFOR - An isolated and pure crystalline rotigotine base of polymorph Form I, and processes for producing the crystalline rotigotine base are disclosed. Also disclosed is a transdermal patch for the delivery of rotigotine base using the disclosed isolated and pure form of rotigotine base, which can be used in treatment of Parkinson's Disease and other disorders ameliorated or treated by rotigotine, including restless leg syndrome. | 2013-04-18 |
20130096322 | METHOD OF BIOBASED CHEMICAL PRODUCTION FROM CRUDE BIOGLYCERIN OF RECYCLED OIL, GREASE, AND FAT ORIGIN - A method of production of value-added, biobased chemicals, derivative products, and/or purified glycerin from bioglycerin of recycled oil, grease, and/or fat origin is described herein. A method of purification of bioglycerin of recycled oil, grease, and/or fat origin is also described herein. The method of purification of bioglycerin of recycled oil, grease, and/or fat origin described provides methods for desalinating, decolorizing, and/or concentrating bioglycerin of recycled oil, grease, and/or fat origin for the production of biobased chemicals, derivative products, and/or purified glycerin. | 2013-04-18 |
20130096323 | NOVEL MIXTURE AND COMPOUNDS FROM MYCELIA OF ANTRODIA CAMPHORATA AND USE THEREOF - The present invention relates to a compound derived from mycelium of | 2013-04-18 |
20130096324 | PROCESS FOR PREPARING OPTICALLY ACTIVE ANTROCIN - The present invention relates to a process of preparation of optically active antrocin. At first, to introduce the correct configuration of trans-decalone, alkyl aluminum/TMSCN was used to react with decalenone. The resulting racemic nitrile-decalone was resolved with chiral diol by ketalization to produce two chromatography separable diasteromers. After a simple column chromatography, optically pure compounds were obtained. Formylation was a critical step for the lactone formation. The rest of the synthesis is straight forward through oxidation and olefination. Accordingly, the total synthesis was completed in 10 steps with 7% overall yield from commercially available 6-methoxy-2-tetralone. | 2013-04-18 |
20130096325 | POLYMORPHIC FORMS OF LUBIPROSTONE - There is provided a crystalline form of Lubiprostone, termed APO-II and methods for making APO-II. APO-II is a polymorphic form of Lubiprostone. | 2013-04-18 |
20130096326 | METHOD OF BIOBASED CHEMICAL PRODUCTION FROM CRUDE BIOGLYCERIN - A method of purification and production of value-added, biobased chemicals and derivative products from crude bioglycerin is described herein. The present method provides methods for desalinating, decolorizing, and concentrating bioglycerin for the production of biobased chemicals or purified bioglycerin. | 2013-04-18 |
20130096327 | METHOD FOR PREPARING CHLOROHYDRINS AND METHOD FOR PREPARING EPICHLOROHYDRIN USING CHLOROHYDRINS PREPARED THEREBY - A method of preparing chlorohydrins and a method of preparing epichlorohydrin by using chlorohydrins prepared using the method are provided. The method of preparing chlorohydrins by reacting polyhydroxy aliphatic hydrocarbon with a chlorination agent in the presence of a catalyst includes at least one combination of a series of unit operations including a first reaction step, a water removal step, and a second reaction step, in that respective order, wherein the method further includes purifying chlorohydrins from a reaction mixture discharged from a final reaction step of the plurality of reaction steps. The method of preparing epichlorohydrin includes reacting chlorohydrins prepared using the method of preparing chlorohydrins, with an alkaline agent. | 2013-04-18 |
20130096328 | PROCESS FOR PREPARING AN EPOXIDE FROM AN OXYGENATE - The invention relates to an integrated process for preparing an epoxide from an oxygenate, wherein the production of a lower olefin from the oxygenate and the subsequent epoxidation of the lower olefin is combined and wherein isobutene, a by-product of the lower olefin production, is converted into a hydroperoxide that is used for the conversion of the lower olefin into the corresponding epoxide. | 2013-04-18 |
20130096329 | PROCESS FOR PREPARING AN EPOXIDE FROM AN OXYGENATE - The invention relates to an integrated process for preparing an epoxide from an oxygenate, wherein the oxygenate is converted into a lower olefin and the lower olefin is subsequently epoxidised, and wherein isobutane obtained after hydrogenation and subsequent normal/iso separation of C4 hydrocarbons obtained as by-product of the oxygenate conversion, is converted into a hydroperoxide that is used for the conversion of the lower olefin into the corresponding epoxide. | 2013-04-18 |
20130096330 | EPOXIDATION PROCESS WITH ADDED MODERATOR - A method for the epoxidation of an olefin comprising the steps of reacting a feed gas composition containing an olefin, oxygen, and a moderator having an optimal moderator concentration in the presence of an epoxidation catalyst at a first temperature and having a first selectivity; and increasing the optimal moderator concentration to a second moderator concentration and whereby the first selectivity is lowed to a second selectivity and the first temperature to a second temperature. | 2013-04-18 |
20130096331 | INTERESTERIFICATION OF LOW SATURATE SUNFLOWER OIL AND RELATED METHODS AND COMPOSITIONS - A method of producing a interesterified oil includes providing sunflower oil comprising no more than about 4% total saturated fat and interesterifying the sunflower oil. Another method of producing a interesterified oil includes providing sunflower oil comprising about 3.3% or less total combined palmitic acid (16:0) and stearic acid (18:0), and interesterifying the sunflower oil. | 2013-04-18 |
20130096332 | METHOD FOR INCREASING THE CONTENT OF DOCOSAHEXAENOIC ACID IN FAT-CONTAINING MATERIALS OR IN FATS AND OILS - To provide a fat-and-oil in which the content of docosahexaenoic acid is increased. A process for producing highly unsaturated fatty acids comprising culturing a stramenopile capable of producing highly unsaturated fatty acids in a culture medium containing an inhibitor for fatty acid desaturases; fats-and-oils in which the content of highly unsaturated fatty acids, particularly docosahexaenoic acid produced by the relevant method, is increased. A method for enhancing the productivity of highly unsaturated fatty acids in stramenopiles, comprising culturing a stramenopile in a culture medium containing an inhibitor for fatty acid desaturases; stramenopiles having the enhanced productivity of highly unsaturated fatty acids, generated by the relevant method. Particularly, the process for producing highly unsaturated fatty acids, the method for enhancing the productivity of highly unsaturated fatty acids, and the stramenopile having the enhanced productivity of highly unsaturated fatty acids, wherein the stramenopile is a microorganism classified into | 2013-04-18 |
20130096333 | Chiral Heterogeneous Catalyst for Assymmetric Nitroaldol Reaction - The present invention relates to the preparation of highly efficient chiral heterogeneous catalyst for asymmetric nitroaldol reaction, wherein Henry reactions of various aldehydes such as aromatic, aliphatic, α,β-unsaturated aldehydes, alicyclic aldehydes and nitroalkenes were carried out to produce optically active β-nitroalcohols in high yield, with moderate to excellent enantioselectivity (ee up to >99%) in presence of a base and an optically active chiral heterogeneous catalyst. | 2013-04-18 |
20130096334 | Magnetic Nanoparticle-Supported Glutathione as a Sustainable Organocatalyst - This invention relates to the use of nano-organocatalysts, and, more specifically, to the use of magnetic nanomaterial-supported organocatalysts. It is an object of the present invention to provide “green” catalysts and protocols. According to one embodiment of the invention, a nano-organocatalyst in the form of a magnetic nanomaterial-supported organocatalyst is provided. According to other embodiments of the invention, glutathione and cysteine are provided as organocatalysts and magnetic nanomaterial-supported glutathione and magnetic nanomaterial-supported cysteine are provided for use as nano-organocatalysts. According to another embodiment of the invention, a method of using a recyclable magnetic nanomaterial-supported organocatalyst using a totally benign aqueous protocol, without using any organic solvent in the reaction or during the workup, is provided. According to a further embodiment of the invention, a recyclable magnetic nanomaterial-supported organocatalyst for various organocatalytic reactions, including but not limited to Paal-Knorr reactions, aza-Michael addition and pyrazole synthesis, is provided. | 2013-04-18 |
20130096335 | PROCESS FOR SYNTHESIS OF SILANE DIPEPTIDE ANALOGS - The invention provides a method of preparing silane dipeptide analogs, comprising the steps of treating a solution of a substituted 1,2-oxasilolane with lithium metal to form a solution of the dilithium salt of a substituted 3-hydroxypropylsilanol, and reacting the solution of the dilithium salt of the substituted 3-hydroxypropylsilanol with a substituted enamine. | 2013-04-18 |
20130096336 | ALKYNYL-SUBSTITUTED INDENOFLUORENES USEFUL IN ELECTRONIC AND ELECTRO-OPTICAL DEVICES - Indenofluorenes that include at least two alkynyl-containing substituents. | 2013-04-18 |
20130096337 | Process for Preparation of Optically Active Compounds using Transfer Hydrogenation - A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drug substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmetric catalytic reduction and transfer hydrogenation, thereby providing an improved route to forming drug substances such as rivastigimine and rivastigimine hydrogen tartrate. | 2013-04-18 |
20130096338 | ASYMMETRIC CYCLIZATION PROCESSES USING UNSATURATED NITRO COMPOUNDS - Disclosed are processes of forming a compound (33), (35) or (37) | 2013-04-18 |
20130096339 | METHOD FOR PRODUCING 1-AMINO-1-ALKOXYCARBONYL-2-VINYLCYCLOPROPANE - It is an object of the present invention to provide a novel method for producing (1R,2S)/(1S,2R)-1-amino-1-alkoxycarbonyl-2-vinylcyclopropane which is useful as a synthetic intermediate of therapeutic agents for hepatitis C and a synthetic intermediate thereof. According to the present invention, when a trans-2-butene derivative having a leaving group at each of the 1- and 4-positions is reacted with a malonic ester in the presence of a base, a specific amount of an alkali metal alkoxide or an alkali metal hydride is used as the base, and further a specific amount of a malonic ester is used to produce a cyclopropane diester, and further, chiral or achiral 1-amino-1-alkoxy-carbonyl-2-vinylcyclopropane and a salt thereof are synthesized using the cyclopropane diester. | 2013-04-18 |
20130096340 | AMINO ACID GROUP-MODIFIED ORGANOPOLYSILOXANE AND SILANE, AMINO ACID GROUP-CONTAINING COMPOUND, AND PRODUCTION METHOD THEREOF - An amino acid-modified organopolysiloxane is provided. It has an amino acid derivative bonded to at least one silicon atom of the organopolysiloxane segment constituting the backbone of the organopolysiloxane via an amide bond represented by the following general formula (1): | 2013-04-18 |
20130096341 | Methanol Carbonylation System with Multiple Absorber Feed Options - A methanol carbonylation system | 2013-04-18 |
20130096342 | DEPOLYMERIZATION OF POLYLACTIC ACID - The invention provides energy efficient depolymerization of polyesters such as post-consumer polylactic acid. Ultrasonic induced implosions can be used to facilitate the depolymerization. The expanding market of polylactic acid-based plastic products, such as water bottles and packaging materials, has raised concerns of contaminating the recycling stream, which is largely filled with petroleum-based plastics. Thus the development of an energy efficient and economically viable PLA recycling process is urgently needed. Post consumer PLA was exposed to methanol as the suspension media in the presence of organic or ionic salts of alkali metals such a potassium carbonate and sodium hydroxide as depolymerization catalysts to provide high quality lactic acid monomers in high yield. | 2013-04-18 |
20130096343 | PROCESS FOR REMOVING, ISOLATING AND PURIFYING DICARBOXYLIC ACIDS - A process for removing, isolating and purifying dicarboxylic acid from fermentation broths, which includes the following steps: 1) removal of the biomass and any solids present from the fermentation broth in two successive stages, 2) removal of the dicarboxylic acid solution from the biomass-free fermentation broth by simulated moving bed (SMB) chromatography, 3) fine purification of the dicarboxylic acid solution, 4) multistage evaporative concentration and crystallization, and 5) separation and drying of the crystals. | 2013-04-18 |
20130096344 | NITRILE HYDRATION CATALYZED BY RECYCLABLE RUTHENIUM COMPLEXES - A method for hydrating a nitrile derivative to generate an amide derivative is provided. The method includes mixing the nitrile derivative with a ruthenium catalyst complex in an aqueous solution to form a mixture, and reacting the nitrile derivative with water in the aqueous solution and in the presence of the ruthenium catalyst complex to form a reacted mixture comprising the amide derivative. The ruthenium catalyst complex is represented by the following structural formula: RuX | 2013-04-18 |
20130096345 | Modafinil Compositions - Polymorphs and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and discussed. In addition, said forms are described as useful for the treatment of many conditions including, but not limited to, narcolepsy. | 2013-04-18 |
20130096346 | RESOLUTION METHODS FOR ISOLATING DESIRED ENANTIOMERS OF TAPENTADOL INTERMEDIATES AND USE THEREOF FOR THE PREPARATION OF TAPENTADOL - Provided herein is an improved and industrially advantageous optical resolution method for resolving (2R,3R)/(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol, and use thereof for the preparation of tapentadol or a pharmaceutically acceptable salt thereof. Provided further herein is an improved and industrially advantageous optical resolution method for resolving (2R,3R)/(2S,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine, and use thereof for the preparation of tapentadol or a pharmaceutically acceptable salt thereof. Disclosed also herein is an improved, commercially viable and industrially advantageous process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof in high yield and purity. | 2013-04-18 |
20130096347 | NOVEL PROCESS FOR PREPARING HIGHLY PURE TAPENTADOL OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF - Provided herein is a novel, commercially viable and industrially advantageous process for the preparation of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol (Tapentadol), or a pharmaceutically acceptable salt thereof, and its intermediates, in high yield and purity. Provided also herein are novel solid state forms of tapentadol intermediates and processes for their preparation thereof. Provided further herein is a purification process for preparing highly pure tapentadol hydrochloride. | 2013-04-18 |