| 15th week of 2011 patent applcation highlights part 26 |
| Patent application number | Title | Published |
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| 20110086298 | SUBSTRATE HOLDING DEVICE, LITHOGRAPHY APPARATUS USING SAME, AND DEVICE MANUFACTURING METHOD - The substrate holding device of the present invention includes a holding unit that adsorbs and holds the substrate, a measuring section that measures a physical quantity relating to a adsorption force of the holding unit with the substrate mounted on the holding unit; and a control section that carries out a first determination based on a first condition and a measurement result obtained by the measuring section and a second determination based on a second condition that is different from the first condition and a measurement result obtained by the measuring section to select one of at least three preset operations based on the result of first and second determinations to thereby execute processing depending on the selected operation. | 2011-04-14 |
| 20110086299 | LIGHT SHOCK RESISTANT PROTECTIVE LAYER - Embodiments pertain to a novel imaging member, namely, an imaging member or photoreceptor comprising a removable protective outer layer which comprises light-absorbing material which substantially prevents any light absorption by the overcoat layer. Thus, the light-absorbing material reduces the intrinsic light shock suffered by conventional overcoat layers without negatively impacting electrical properties of the overcoat layer while improving print quality. | 2011-04-14 |
| 20110086300 | PHOTORECEPTOR SURFACE LAYER COMPRISING SECONDARY ELECTRON EMITTING MATERIAL - Presently disclosed embodiments relate to an improved electrophotographic imaging member or photoreceptor comprising a surface layer on the photoreceptor, where the surface layer comprises secondary electron emitting materials that act as a robust electrically active layer. Photoreceptors incorporating such materials into or on the surface will exhibit an increase photoreceptor life and also a reduction the operating voltage of bias charge roll (BCR) charging systems while maintaining excellent charge uniformity. | 2011-04-14 |
| 20110086301 | EMULSION AGGREGATION TONER COMPOSITION - A toner composition that includes at least one low molecular weight amorphous polyester resin, at least one high molecular weight amorphous polyester resin, at least one crystalline polyester resin, at least one wax, at least one biocide and at least one colorant, and wherein the toner composition has a minimum fusing temperature of from about 100° C. to about 125° C. | 2011-04-14 |
| 20110086302 | TONER COMPOSITIONS AND PROCESSES - An emulsion aggregation toner composition includes toner particles including: an unsaturated polymeric resin, such as amorphous resins, crystalline resins, and combinations thereof; an optional colorant; an optional wax; an optional coagulant; and an IR absorber. The use of an IR absorber may permit formation of color toners that have uniform gloss and crease properties, i.e., the IR absorbers may prevent gloss and crease differences between color and black toners. | 2011-04-14 |
| 20110086303 | TONER COMPOSITIONS AND PROCESSES - An emulsion aggregation toner composition includes toner particles including: an unsaturated polymeric resin, such as amorphous resins, crystalline resins, and combinations thereof; an optional colorant; an optional wax; an optional coagulant; and an IR absorber. The use of an IR absorber may permit formation of color toners that have uniform gloss and crease properties, i.e., the IR absorbers may prevent gloss and crease differences between color and black toners. | 2011-04-14 |
| 20110086304 | TONER COMPOSITIONS - The present disclosure provides toners and methods for their production. In embodiments, the toner may include a core/shell configuration, with a non-crosslinked resin and a crosslinked resin in the core, with a second non-crosslinked resin in the shell, pigment/pigments and a wax possessing both branched and linear carbons. | 2011-04-14 |
| 20110086305 | TONER, METHOD OF MANUFACTURING TONER, DEVELOPER, AND IMAGE FORMING METHOD - A toner including a mother toner comprising a binder resin and a calixarene having a halogen group, and a charge controlling agent having a halogen group that is present on a surface of the mother toner. The ratio of halogen ion to carbon ion on a surface of the toner is from 0.01 to 0.5, when determined by TOF-SIMS. The toner can be prepared by preparing a first liquid by dissolving or dispersing toner components including a calixarene having a halogen group and a binder resin and/or a precursor of the binder resin in an organic solvent; preparing a second liquid by emulsifying or dispersing the first liquid in an aqueous medium; removing the organic solvent from the second liquid; preparing a third liquid by washing the second liquid from which the organic solvent is removed; and adding a charge controlling agent having a halogen group to the third liquid. | 2011-04-14 |
| 20110086306 | TONER COMPOSITIONS - A toner having charge control agents which impart excellent triboelectric charging characteristics. In embodiments, the charge control agents include copolymers formed by an emulsion polymerization process. | 2011-04-14 |
| 20110086307 | CARRIER FOR TWO-COMPONENT DEVELOPER - A carrier, including a magnetic particulate core material and a resin layer on the core material, wherein the resin layer includes a resin obtained by heat treatment of a copolymer including a site derived from a monomer component having the following formula (1) and a site derived from a monomer component having the following formula (2), and includes a cross-linked material obtained by hydrolysis of the copolymer to produce a silanol group and condensation using an organotitanium compound: | 2011-04-14 |
| 20110086308 | TONER, VESSEL WITH THE TONER, DEVELOPER, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE AND IMAGE FORMING METHOD - Toner and a developer which are excellent in cleaning property and fixing property at low temperature, and capable of forming images with high quality are provided, along with a method for their production. A toner producing method involves dispersing and/or emulsifying an oil phase or a monomer phase containing a toner composition and/or a toner composition precursor in a water-based medium to granulate, | 2011-04-14 |
| 20110086309 | PHOTOSENSITIVE RESIN COMPOSITION, PHOTOSENSITIVE ELEMENT, METHOD OF FORMING RESIST PATTERN, AND PROCESS FOR PRODUCING PRINTED WIRING BOARD - The invention provides a photosensitive resin composition comprising (A) 100 parts by weight of a binder polymer having 10-65 parts by weight of a divalent group obtained from a specific styrene compound and its derivative, 5-55 parts by weight of a divalent group obtained from a specific (meth)acrylic acid ester and its derivative and 15-50 parts by weight of a divalent group obtained from (meth)acrylic acid, (B) a photopolymerizing compound and (C) a photopolymerization initiator. | 2011-04-14 |
| 20110086310 | POSITIVE RESIST COMPOSITION AND METHOD FOR PRODUCTION OF MICROLENS - There is provided a positive resist composition excellent in transparency, heat resistance, and refractive index particularly for forming a microlens and for forming a planarization film; and a microlens and a planarization film formed from the positive resist composition. A positive resist composition comprising a component (A): an alkali-soluble polymer comprising a unit structure having a biphenyl structure; a component (B): a compound having an organic group to be photolyzed to generate an alkali-soluble group; and a component (C): a solvent. The positive resist composition wherein the alkali-soluble polymer as the component (A) is a polymer comprising a unit structure of Formula (1): | 2011-04-14 |
| 20110086311 | BASE GENERATOR, PHOTOSENSITIVE RESIN COMPOSITION, PATTERN FORMING MATERIAL COMPRISING THE PHOTOSENSITIVE RESIN COMPOSITION, AND PATTERN FORMING METHOD AND ARTICLE USING THE PHOTOSENSITIVE RESIN COMPOSITION - A photosensitive resin composition which is excellent in resolution, low in cost, and usable in a wide range of structures of polymer precursors each of which is reacted into a final product by a basic substance or by heating in the presence of a basic substance. The photosensitive resin composition includes a base generator which has a specific structure and generates a base by exposure to electromagnetic radiation and heating, and a polymer precursor which is reacted into a final product by the base generator and by a basic substance or by heating in the presence of a basic substance. | 2011-04-14 |
| 20110086312 | Positive-Working Photoimageable Bottom Antireflective Coating - The present invention relates to a positive bottom photoimageable antireflective coating composition which is capable of being developed in an aqueous alkaline developer, wherein the antireflective coating composition comprises a polymer comprising at least one recurring unit with a chromophore group and one recurring unit with a hydroxyl and/or a carboxyl group, a vinyl ether terminated crosslinking agent of structure (7), and optionally, a photoacid generator and/or an acid and/or a thermal acid generator, where structure (7) is | 2011-04-14 |
| 20110086313 | METHOD AND SYSTEM OF MANUFACTURING SEMICONDUCTOR DEVICE - In one embodiment, a method is disclosed for manufacturing a semiconductor device. The method can forms a resist film on a substrate. The method can expose a portion of the resist film. The portion is formed on a device area of the substrate and the device area includes a center portion of the substrate. After the exposing the device area, the method can apply a reaction control process for controlling expansion of a reacted region in the resist film. After the applying the reaction control process, the method can expose another portion of the resist film and the another portion is formed on a peripheral area surrounding the device area. After the exposing the peripheral area, the method can heat the resist film, and after the heating, the method can develop the resist film. | 2011-04-14 |
| 20110086314 | MELTS - A light-attenuating composition and method of using it are described. The light-attenuating composition may be selectively applied to a radiant energy sensitive material on the substrate. Actinic radiation applied to the composite chemically changes portions of the radiant energy sensitive material not covered by the light-attenuating composition. The light-attenuating composition attenuates light in at least the UV range and is water-soluble or water-dispersible. | 2011-04-14 |
| 20110086315 | EXPOSURE APPARATUS, EXPOSURE METHOD, AND DEVICE MANUFACTURING METHOD - A first driving section and a second driving section apply a drive farce in an X-axis direction, a Y-axis direction, a Z-axis direction, and a θx direction, respectively, with respect to one end and the other end of a fine movement stage whose one end and the other end in the Y-axis direction are each supported, so that the fine movement stage is relatively movable with respect to a coarse movement stage within an XY plane. Accordingly, by the first and the second driving sections making drive forces in directions opposite to each other in a θx direction apply simultaneously to one end and the other end of the fine movement stage (refer to the black arrow in the drawing), the fine movement stage (and the wafer held by the stage) can be deformed to a concave shape or a convex shape within a YZ plane. | 2011-04-14 |
| 20110086316 | COATING AND DEVELOPING APPARATUS AND COATING AND DEVELOPING METHOD - Disclosed is a coating and developing apparatus including (a) a first liquid process module to sequentially perform a first liquid process by a first chemical liquid, and a second liquid process by the first chemical liquid again; (b) a buffer module to sequentially store the respective substrates which have been subjected to the first liquid process and have not yet been subjected to the second liquid process; and (c) a second liquid process module to sequentially perform a third liquid process by a second chemical liquid. In particular, the third liquid process to be performed on a first substrate of the substrate group is started before the first liquid process performed on a last substrate of the substrate group is ended, in such a manner that right after the first liquid process is performed on the last substrate, the second liquid process is to be performed on the first substrate. | 2011-04-14 |
| 20110086317 | DOUBLE-SIDED PHOTOSENSITIVE COLOR PHOTOGRAPHIC PAPER AND METHOD OF MANUFACTURING THE SAME - The present invention relates to a double-sided photosensitive color photographic paper and a method for manufacturing the same. The photographic paper comprises a paper base, and a first photosensitive layer and a second photosensitive layer provided on two opposite sides of the paper base, respectively, wherein a silver shading layer is coated between the paper base and the first photosensitive layer and/or between the paper base and the second photosensitive layer. The function of the silver shading layer is to block majority of light so that light exposed to one side of the photographic paper will not expose to the photosensitive layer on the other side of the photographic paper. Therefore, undesired images on the other photosensitive layer and degradation of the original imaging quality can be avoided. Sliver in the silver shading layer can be removed during the development of the photographic paper, and the final viewing quality of the photographic paper will not be impacted. | 2011-04-14 |
| 20110086318 | METHOD AND APPARATUS FOR MAINTAINING STABLE FLAME CONDITIONS IN A GAS BURNER - A gas burner apparatus comprising a burner base disposed over a gas burner, a burner head disposed over the burner base, and one or more burner covers disposed over the burner head. A method comprising a burner base over a gas burner, providing a burner headwith one or more burner ports over the burner base, providing one or more burner covers over the burner head, and sliding one or more burner covers over at least one of the one or more burner ports. | 2011-04-14 |
| 20110086319 | FUEL GAS IGNITION SYSTEM FOR GAS BURNERS INCLUDING DEVICES AND METHODS RELATED THERETO - Featured is a gas burner ignition system using miniaturized hot surface igniters of various types configurations and material systems: The ignition system includes an electronic microprocessor which controls both the igniter operation and all functions of the ignition system. | 2011-04-14 |
| 20110086320 | COLORED FLAME CANDLE - A candle flame candle which is constructed of a center wick and a body of wax surrounding the center wick except a tip portion of wick wherein the wick is impregnated with at least one of a coloring agent and a color enhancer. | 2011-04-14 |
| 20110086321 | JAW HOLD OPEN APPARTUS - This document discloses, among other things, an apparatus for preventing closure of an animal mouth. A harness is fitted around the neck and the lower jaw of the animal and maintains an intraoral piece at a position in the back of the mouth. It also includes a method for holding the animal's jaw open. | 2011-04-14 |
| 20110086322 | METHOD FOR DESIGNING ORTHODONTIC APPARATUS - A method of producing a customized orthodontic appliance ( | 2011-04-14 |
| 20110086323 | Self-Ligating Bracket for Orthodontics - The bracket comprising
| 2011-04-14 |
| 20110086324 | METHOD FOR MAKING AND USING A TEMPLATE FOR LOCATING A DENTAL IMPLANT AND COMPONENTS RELATING THERETO - A method for making a template for a dental implant osteotomy in an edentulous space of a patient's mandible or maxilla, and components relating thereto. The method includes the steps of forming a dental cast of the patient's mandible or maxilla, drilling a hole into the dental cast wherein the location and orientation of the hole correspond to a desired location and orientation of the dental implant osteotomy, inserting a guide post into the hole, magnetically attaching a sleeve having a longitudinal gap to the guide post, applying a molding material to a portion of the dental cast and to a portion of an outer surface of the sleeve, allowing the molding material to cure, and removing the cured template including the sleeve embedded therein from the dental cast, whereby using the template in the patient's mouth provides a guide means for drilling the osteotomy. | 2011-04-14 |
| 20110086325 | IMPLANT AND A METHOD FOR USING THE SAME - A dental implant for coupling an artificial tooth to a jawbone of a patient is provided. The dental implant comprises an elongated body having a first end threaded bone-engaging portion for engaging the dental implant with the jawbone and a second end, and wherein the dental implant is adapted to operate as a conduit for bone grafting material by enabling introduction of the bone grafting material into a grafting space extending between said elongated body and the patient's jawbone surrounding it. Preferably, the dental implant comprises a plurality of longitudinal grooves located at the external surface of the threaded bone-engaging portion of the dental implant, or comprises circumferentially located openings, to allow delivery of bone grafting material into the grafting space. | 2011-04-14 |
| 20110086326 | DENTAL PROSTHETIC DEVICE AND ACCESSORY THEREOF - Provided is a dental prosthetic device that are adapted for replacing a lost tooth and recovering a damaged tooth. An adjusting member is attached to an adjacent tooth to the lost or damaged tooth to adjust the slope and undercut of the adjacent tooth and to install an artificial tooth. | 2011-04-14 |
| 20110086327 | Combination UCLA Impression Coping and Installation Procedure - A UCLA castable abutment and impression taking component are combined into one unit. The shape of the plastic distal end of the UCLA abutment is fabricated so that it will have one or more undercuts as well as one or more anti-rotation features to allow it to be used while taking an impression of the abutment's relationship to the implant using the indirect transfer method. The combination of an anti-rotation and undercut feature allow the UCLA abutment to be gripped by the impression. The unit includes a bore to allow a fixation screw to fixate the unit to either an implant or implant analog. | 2011-04-14 |
| 20110086328 | METHOD AND APPARATUS FOR PRODUCING A DENTAL IMPLANT - A dental implant may be produced having an organic shape corresponding to the root shape of a tooth the implant replaces. Following atraumatic extraction of the tooth, the implant may be inserted and subsequently graft to the root socket. Features of the implant maximize compatibility and positive outcomes. | 2011-04-14 |
| 20110086329 | DEVICE AND METHOD FOR DELIVERING AN ORAL CARE AGENT - An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time. | 2011-04-14 |
| 20110086330 | ETHNIC AWARENESS EDUCATION GAME SYSTEM AND METHOD - A game system for ethnic awareness education game play includes a video display device, a remote controller for controlling the video display device, and a video display device readable media. The media is operable to cause the video display device to: display a first question; display the correct answer to the first question; display a second question after displaying the correct answer to the first question; and terminate game play when a termination prompt is received from the remote controller. | 2011-04-14 |
| 20110086331 | SYSTEM FOR TEACHING WRITING BASED ON A USERS PAST WRITING - A computer-assisted system including a memory storing samples of a user's past writing including mistakes and corrections thereof and a writing learning processor employing the samples of the user's past writing including mistakes and correactions thereof for providing lessons, exercises, games and tests to the user. | 2011-04-14 |
| 20110086332 | SIMULATION SYSTEM FOR TRAINING IN ENDOSCOPIC PROCEDURES - A simulation system for training in endoscopic procedures includes an endoscope apparatus, which includes an operating part with at least one valve, a control device to generate a virtual image of an endoscopic operating scene depending on an actuation of the valve and a display device to display the virtual image, the endoscope apparatus includes for example a siphoning line, an insufflation line and/or a flushing line upon which the valve acts. The simulation system includes pressure-generating means to impact the siphoning line, the insufflation line and/or the flushing line with reduced or excess pressure, sensor means to measure pressure and/or flow in the siphoning line, the insufflation line and/or the flushing line and transmission means to transmit the measured values provided by the sensor means to the control device to be used in generating the virtual image. | 2011-04-14 |
| 20110086333 | EDUCATIONAL TOOL FOR LEARNING QUANTUM SCIENCE - A rotational operator is applied once or twice to a product of a wave function of quantum mechanics for a dynamic system and a unit vector in a θ-direction in a polar coordinate system (r, θ, φ) to obtain a first or second vector function, respectively. A starting coordinate is substituted into the first or second vector function to obtain a starting value of the vector function, and a next coordinate a small distance away from the starting coordinate in a direction of the starting value of the vector function is calculated. This process is iterated and segments linking the coordinates one after another are drawn on a medium, such as a sheet, as a magnetic or electric line of force. The process is iterated with replacing the initial starting coordinate with another initial one to obtain another magnetic or electric line of force. | 2011-04-14 |
| 20110086334 | Chez Educational System - The educational system is an educational delivery system through the use of “live” video instruction by a certified instructor and is coordinated with specific sequential support materials for the student as directed by a facilitator of the program. The curriculum is created and performed by the “live” instructor. The prototype curriculum employs a chemistry content titled | 2011-04-14 |
| 20110086335 | WEAR AND WRITE DRY-ERASE NOTEPAD - A portable dry erase notepad for instantly jotting down notes, daily tasks, measurements for engineering and construction, grocery lists, phone numbers, e-mail and home addresses, sketches, etc. while in the car, in the workplace, in class; and at a meeting, party, or any event. The portable dry erase notepad includes a note screen comprises a rectangular panel of dry erase material with rounded edges and or a material being metallic or plastic with a gloss-white dry-erase coating. The note screen is framed in a leather or vinyl faux leather exterior cover that securely seats the note screen leaving the clear or white dry-erase surface exposed. An elastic loop is sewn into the margins of the exterior cover for securing a dry erase marker pen alongside. The dry erase marker pen is equipped with an eraser. The backside of the exterior cover is selectively equipped with a variety of attachment mechanisms, primarily an elastic fabric cuff with hook and look insets for secure wrist-attachment, though a belt clip and/or retractable tether are also provided. The portable dry erase notepad is aesthetically and looks good on the wrist or body, even with the integral marker docked thereto for convenient access, and offers an instant resource for jotting down notes, daily tasks, grocery lists, phone numbers, e-mail and home addresses, measurements or sketches, etc. virtually anywhere. | 2011-04-14 |
| 20110086336 | Reproductive cell maintenance system - Extracts obtained from the genus | 2011-04-14 |
| 20110086337 | FLUID TRANSFER CONTROL FOR REAL-TIME PCR - The present invention provides a fluid transfer control method, the method based on measurements of intensities of dyes within the fluid to be transferred. In more detail, the present invention makes use of control dyes and quencher molecules for the fluid transfer controls. | 2011-04-14 |
| 20110086338 | Bacteriophage/Quantum-Dot (Phage-QD) Nanocomplex to Detect Biological Targets in Clinical and Environmental Isolates - The invention is related to a non-biotinylated bacteriophage that comprises a nucleic acid sequence encoding a biotinylation domain, a complex that comprises a biotinylated bacteriophage and a biotin-specific ligand conjugated bioconjugate, and a method of detecting a bacterial cell in a sample comprising contacting the sample with a non-biotinylated bacteriophage that comprises a nucleic acid sequence encoding a biotinylation domain, wherein the bacteriophage is specific to the bacterial cell. | 2011-04-14 |
| 20110086339 | ELIMINATION OF PATHOGENIC INFECTION IN FARMED ANIMAL POPULATIONS - Animal husbandry has always been susceptible to the ravages of pathogenic infections. Poultry flus and cattle diseases are but two examples that have dire consequences for animals and adversely affect the economic fortunes of farmers. A testing and culling methodology is presented that can eliminate pathogens from an infected herd. The sensitivity of PCR to detect very low levels of nucleic acid of an infecting pathogen is utilized to identify infected animals. In addition, it has been discovered that PCR analysis of manure samples can accurately identify infected animals and offspring for those species that consume placental remains after birth. Mink Aleutian Disease Virus (mADV) is one of several deadly DNA parvoviruses that can quickly reach epidemic proportions in a mink herd. PCR primers have been developed that generate amplicons to detect and identify the mADV. In addition, a previously unidentified strain of mADV has been discovered, genomically sequenced, and substantially detailed. | 2011-04-14 |
| 20110086340 | METHODS, DEVICES, KITS AND COMPOSITIONS FOR DETECTING ROUNDWORM - Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a mammalian sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, whipworm, and heartworm. Confirmation of the presence or absence of roundworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated. | 2011-04-14 |
| 20110086341 | FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION - The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats. | 2011-04-14 |
| 20110086342 | Hepatocellular Carcinoma-Associated Gene - The present invention provides a method for evaluating cancer, which comprises the following steps of:
| 2011-04-14 |
| 20110086343 | METHOD FOR THE SCREENING OF BACTERIAL ISOLATES - Present invention relates to a method to determine the genotype of organisms by RAPD analysis and more specifically, to establish the relatedness of individual organisms across and within species. RAPD uses genotypic information of an organism to give an organism specific DNA fragment of different sizes. The present invention provide methods and a set of oligonucleotide primers for performing amplification and other enzymatic reactions on nucleic acid molecules that have been collected directly as environmental DNA or DNA derived form pure isolates. More specifically, the present invention relates to a novel method of genetic analysis using a set of sub-sequence, which occurs as inverted repeats in different genome with different frequencies. All bacterial cultures used in this study have been isolated from activated biomass collected from effluent treatment plants. The bacteria have been sub-cultured repeatedly to obtain pure cultures. All plating has been carried out on Luria Broth plates with 2% agar. The 16S rRNA gene has been amplified using universal primers to confirm the eubacterial nature of the isolates. The primers used to amplify a 1466-bp product were 27F forward primer 5′-AGAGTTTGATCMTGGCTCAG-3′ and 1492 reverse primer 5′-TACGGYTAC-CTTGTTACGACTT-Hence, in defined conditions two genome samples could be differentiated from each other. These features are applicable to DNA fingerprinting, marker assisted selection, genotyping, and high throughput laboratory screening methods for culturable microbes from any environmental niche. | 2011-04-14 |
| 20110086344 | METHODS OF CHARACTERIZING SMALL NUCLEIC ACID MOLECULES - The invention generally relates to methods of characterizing small nucleic acid molecules, such as plasmids or nucleic acid molecules obtained from a virus. In certain embodiments, the invention provides a method of characterizing a small circular nucleic acid molecule, the method including performing rolling circle amplification on a small circular nucleic acid molecule, thereby producing a concatamer, and generating an optical map of the concatamer, thereby characterizing the small circular nucleic acid molecule. | 2011-04-14 |
| 20110086345 | ISOLATION AND USE OF RYANODINE RECEPTORS - The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm ( | 2011-04-14 |
| 20110086346 | Novel haplotype tagging single nucleotide polymorphisms and use of same to predict childhood lymphoblastic leukemia - The present invention is directed to novel haplotype tagging single nucleotide polymorphisms (SNPs) in specific regions outside the HFE gene that serve as a reliable biomarker for a decreased risk for childhood lymphoblastic leukemia (ALL) in a child. There is provided herein methods and reagents for assessing the haplotype tagging SNPs selected from the group consisting of rs807212, rs198853, rs9467664, rs2213284, rs2230655 and rs12346. The method useful in applying these SNPs in predicting a decreased risk of childhood lymphoblastic leukemia (ALL) is also disclosed. | 2011-04-14 |
| 20110086347 | CELL DETECTION, MONITORING AND ISOLATION METHOD - The present invention relates generally to a method for identifying or distinguishing one type of cell from other cells within a population of cells. The present invention further provides the detection, monitoring and isolation of sub-populations cell types within a population of cells including a biological entity comprising such cell types. Kits, diagnostic agents and panels of nucleic acid probes for identifying and distinguishing cell types also form part of the present invention. The detection of particular cell types is based upon the use of a labelled probe that hybridizes to chromosomal DNA at the flanking sequences of a deletion. Alternatively two probes with distinguishable reporter molecules are used wherein only one probe is capable of hybridizing to chromosomal DNA in one cell type whereas both are capable of hybridizing to chromosomal DNA in another cell type. The methods are useful in the identification of cells with copy number variations, chromosomal deletions, additions or aberrations. | 2011-04-14 |
| 20110086348 | METHOD FOR ASSESSING HEART DISEASE - A method for assessing heart disease in a subject includes generating an expression profile of at least two or more miRNAs in a sample from the subject. The miRNAs can be selected from the group consisting of hsa-miRNA-1, hsa-miRNA-7, hsa-miRNA-29b, has-miRNA-125b, hsa-miRNA145, hsa-miRNA-181b, hsa-miRNA-214, hsa-miRNA-342, hsa-miRNA-378 and combinations thereof. | 2011-04-14 |
| 20110086349 | Proliferation Signatures and Prognosis for Gastrointestinal Cancer - This invention relates to methods and compositions for determining the prognosis of cancer in a patient, particularly for gastrointestinal cancer, such as gastric or colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as gastric or colorectal cancer, based on cell proliferation signatures. In various aspects, the invention relates to a method of predicting the likelihood of long-term survival of a cancer patient, a method of determining a treatment regime for a cancer patient, a method of preparing a personalized genomics profile for a cancer patient, among other methods as well as kits and devices for carrying out these methods. | 2011-04-14 |
| 20110086350 | ELIMINATION OF PATHOGENIC INFECTION IN FARMED ANIMAL POPULATIONS - Animal husbandry has always been susceptible to the ravages of pathogenic infections. Poultry flus and cattle diseases are but two examples that have dire consequences for animals and adversely affect the economic fortunes of farmers. A testing and culling methodology is presented that can eliminate pathogens from an infected herd. The sensitivity of PCR to detect very low levels of nucleic acid of an infecting pathogen is utilized to identify infected animals. In addition, it has been discovered that PCR analysis of manure samples can accurately identify infected animals and offspring for those species that consume placental remains after birth. Mink Aleutian Disease Virus (mADV) is one of several deadly DNA parvoviruses that can quickly reach epidemic proportions in a mink herd. PCR primers have been developed that generate amplicons to detect and identify the mADV. In addition, a previously unidentified strain of mADV has been discovered, genomically sequenced, and substantially detailed. | 2011-04-14 |
| 20110086351 | ELIMINATION OF PATHOGENIC INFECTION IN FARMED ANIMAL POPULATIONS - Animal husbandry has always been susceptible to the ravages of pathogenic infections. Poultry flus and cattle diseases are but two examples that have dire consequences for animals and adversely affect the economic fortunes of farmers. A testing and culling methodology is presented that can eliminate pathogens from an infected herd. The sensitivity of PCR to detect very low levels of nucleic acid of an infecting pathogen is utilized to identify infected animals. In addition, it has been discovered that PCR analysis of manure samples can accurately identify infected animals and offspring for those species that consume placental remains after birth. Mink Aleutian Disease Virus (mADV) is one of several deadly DNA parvoviruses that can quickly reach epidemic proportions in a mink herd. PCR primers have been developed that generate amplicons to detect and identify the mADV. In addition, a previously unidentified strain of mADV has been discovered, genomically sequenced, and substantially detailed. | 2011-04-14 |
| 20110086352 | Label Free Detection of Nucleic Acid Amplification - Provided are methods and devices for label-free detection of nucleic acids that are amplified by polymerase chain reaction. A solution containing the components necessary for a PCR is introduced to a microfluidic amplification chamber and an electric field applied to a confined region in which PCR occurs. PCR product generated in the confined region is detected by measuring an electrical parameter that is, for example, solution impedance. The devices and methods provided herein are used, for example, in assays to detect one or more pathogens or for point-of-care tests. In an aspect, the PCR product is confined to droplets and the assay relates to detecting an electrical parameter of a flowing droplet, thereby detecting PCR product without a label. In an aspect, the PCR occurs in the droplet. | 2011-04-14 |
| 20110086353 | Identification of MicroRNAs (miRNAs) in Fecal Samples as Biomarkers for Gastroenterological Cancers - A simple, rapid, inexpensive, and promising commercial biomarker assay method for multiple diseases is described herein. The present invention detects miRNA-based biomarkers in human stool specimens. The method of the present invention amplifies miRNA directly from stool specimens without any prior miRNA extraction. Differential expression of specific microRNAs in stool of colorectal cancer CRC and adenoma patients suggest fecal microRNAs as a novel potential biomarker for colorectal neoplasia detection. The method of the present invention has diagnostic, prognostic, and therapeutic relevance for gastroenterological cancers/colorectal cancer and as well as further acquired or hereditary GI diseases. | 2011-04-14 |
| 20110086354 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR AMPLIFICATIONS - The present invention concerns in general PCR reaction mixtures comprising a mixture of hot-start primers and non-hot-start primers for a given target sequence, including multiplex PCR reaction mixtures; methods utilizing same for detection of one or more target polynucleotide sequences; and kits comprising same. | 2011-04-14 |
| 20110086355 | BRCA1 mRNA EXPRESSION LEVELS PREDICT SURVIVAL IN BREAST CANCER PATIENTS TREATED WITH NEOADJUVANT CHEMOTHERAPY - The invention relates to methods for predicting the clinical outcome of a patient which suffers from breast cancer based on the expression levels of BRCA1, wherein low BRCA1 expression levels are indicative of a good prognosis. Moreover, the invention relates to methods for predicting the response to a neoadjuvant therapy based on a combination of an anti-metabolite, an intercalating agent and an alkylating agent of a patient which suffers from breast cancer based on the expression levels of BRCA1. | 2011-04-14 |
| 20110086356 | METHOD FOR MEASURING DNA METHYLATION - The present invention relates to a method of measuring the content of methylated DNA in a DNA region of interest in a genomic DNA contained in a biological specimen, and so on. | 2011-04-14 |
| 20110086357 | Methods for Evaluating a Disease Condition by Nucleic Acid Detection and Fractionation - This invention relates to the discovery that both non-particle and particle associated nucleic acids are present in blood plasma and serum and can be used to evaluate disease conditions. | 2011-04-14 |
| 20110086358 | PROBE, PROBE SET, PROBE CARRIER, AND TESTING METHOD - A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 4 and mutated sequences thereof. | 2011-04-14 |
| 20110086359 | LATERAL FLOW ASSAYS - Assays and methods including mobile tagged single stranded nucleic acid reagents pre-loaded on an analysis device, which are preferably tagged, but not labeled and are complementary to a strand (preferably the anti-sense strand in double stranded DNA targets) of the target nucleic acid. The assay also includes a running buffer that includes a dye or other detectable label that nonspecifically binds only to double stranded nucleic acids. In addition, the analysis device includes a detection zone including one or more test zones that have an immobilized tag that binds to the tag on the mobile nucleic acid reagent. | 2011-04-14 |
| 20110086360 | METHOD FOR DETECTION OF IDIOPATHIC INTERSTITIAL PNEUMONIA - The present invention provides a method for detecting idiopathic interstitial pneumonia, which comprises measuring the expression level of a periostin gene or the amount of a periostin protein in a biological sample. Thereby, a method for detecting idiopathic interstitial pneumonia using a marker is provided. | 2011-04-14 |
| 20110086361 | AMPLIFICATION OF NUCEIC ACIDS USING TEMPERATURE ZONES - The present invention relates to the amplification and detection of amplified nucleic acid sequences employing methods and devices with distinct temperature zones. The methods and devices of the present invention may be used for quantitative analysis of target nucleic acid sequences, for simultaneous quantitative analysis of multiple target nucleic acid sequences or for analyzing a sample for the presence of a target nucleic acid. | 2011-04-14 |
| 20110086362 | High-Throughput Method for Quantifying Sialylation of Glycoproteins - Provided herein methods and kits for detecting and/or quantifying sialic acid content of glycosylated molecules that does not require purification of the glycosylated molecule of interest or purification of the labeled product. The methods and kits provided herein are fast and suitable for high-throughput use. | 2011-04-14 |
| 20110086363 | Method and apparatus to conduct kinetic analysis of platelet function in whole blood samples - Adhesion of platelets to blood vessel walls is the first step that promotes arrest of bleeding by interaction of the platelet receptors with various extracellular matrix proteins that become exposed on vascular injury. A flow chamber is provided for use in analyzing or studying platelet function, in whole blood, either as part of a batch process or in real time. In the flow chambers, an inert polydimethylsiloxane (PDMS) surface is plasma-activated and a homobifunctional cross-linker is used to immobilize platelet-binding proteins onto a chamber wall surface. Immobilized collagen and fibrinogen may thus be assayed by continuously monitoring the adhesion of ADP and Ca | 2011-04-14 |
| 20110086364 | DETECTION OF CANNABIS USE - A binding partner, especially an antibody fragment that specifically recognizes an antigen-antibody immune complex between anti-THC and THC (tetrahydrocannabinol), is disclosed. The binding partner facilitates a non-competitive homogenous immunoassay for detection of | 2011-04-14 |
| 20110086365 | Method for Sensing a Chemical - The present invention relates to a method for detecting an analyte ( | 2011-04-14 |
| 20110086366 | METHODS FOR ASSESSING THE RISK OF ADVERSE EVENTS UPON TREATMENT WITH IGG4 ANTIBODIES - The invention relates to methods and kits for assessing the risk, for an individual, of developing an adverse event upon treatment with a therapeutic antibody which is capable of Fab-arm exchange, said method comprising the steps of: a) providing a sample from an individual who is a candidate for treatment with said therapeutic antibody, b) assaying said sample for the presence of circulating IgG4 antibodies that binds an antigen known or suspected to be associated with a causative agent of said adverse event, and c) assessing, on the basis of the outcome of the assay of step b), the risk that the individual will develop said adverse event upon treatment with the therapeutic antibody, wherein the risk of development of said adverse event increases with increased level of said circulating IgG4 antibodies. | 2011-04-14 |
| 20110086367 | PHARMACEUTICALS FOR INFLUENCING THE REACTION OF THE HUMAN IMMUNE SYSTEM - The present invention uses the potency and efficacy of human glycoprotein-A repetitions predominant protein (GARP), the gene of which is located on chromosome 11q13-11q14 in the reprogramming of antigen-specific effector T-helper cells, which are CD4 | 2011-04-14 |
| 20110086368 | METHOD FOR IMMUNE RESPONSE DETECTION - A method for detecting one or more immunological response factors that is expressed in response to a therapeutic treatment and/or disease using a piezoelectric microcantilever sensor (PEMS) to assess a patient's immunological response. The method involves measuring a frequency shift of the PEMS caused by binding the immunological response factors to one or more receptors on the PEMS. The method may be used to determine the effectiveness of a prescribed therapeutic treatment and/or monitor the progress of a disease. | 2011-04-14 |
| 20110086369 | FLUORESCENT COMPOUNDS FOR THE DIAGNOSIS OF INFECTIONS, PRODUCTION METHOD, AND APPLICATIONS THEREOF - The present invention describes novel fluorescent compounds analogous to alkyl phospholipids, containing highly photostable fluorescent groups in the structure thereof and emitting in the visible spectrum wavelength zone. Said compounds are easily introduced to microorganisms, enabling the detection and identification of these organisms by means of fluorescence microscopy. The novel fluorescent compounds can also diagnose, rapidly and easily, the presence of pathogenic microorganisms characterised in that they are resistant to treatment with alkyl phospholipids. | 2011-04-14 |
| 20110086370 | Protease Detection - A polypeptide comprising a chromogenic amino acid. The chromogenic amino acid is flanked by at least one amino acid to the N and C termini thereof. The amine group of the chromogenic amino acid has a pKa of less than 5. The chromogenic amino acid is capable of reacting with a conjugated aldehyde. The polypeptide comprises a target sequence for a target protease which is capable of cleaving the peptide bond comprising the amino group of the chromogenic amino acid. | 2011-04-14 |
| 20110086371 | URINE AND SERUM BIOMARKERS ASSOCIATED WITH DIABETIC NEPHROPATHY - Use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof. | 2011-04-14 |
| 20110086372 | BIOMARKERS ASSOCIATED WITH NEPHROPATHY - Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof. | 2011-04-14 |
| 20110086373 | CHOLESTEROL SENSOR - A method for the determination of the amount of cholesterol in a sample is provided. The method typically provides a breakdown of the HDL and LDL cholesterol contents of the sample. | 2011-04-14 |
| 20110086374 | Novel Cell-Based Phosphodiesterase Assays - The present invention relates to improved cell-based assays for the in vivo assessment of phosphodiesterase (PDE) activity using cyclic nucleotide-gated channels as cyclic nucleotide sensors, and for the assessment of the effect of PDE modulating compounds. | 2011-04-14 |
| 20110086375 | DEVICES AND METHODS FOR PRODUCTION OF CELL AGGREGATES - The present application provides methods and devices for the production and recovery of cell aggregates. In one embodiment, the device is a microwell device with a high density of microwells. The application also provides a device for extracting cell aggregates such as stem cells or embryoid bodies from well plates. Such cell aggregates are used for the differentiation of pluripotent stem cells such as embryonic stem cells, in the fields of developmental biology and regenerative medicine/tissue engineering. | 2011-04-14 |
| 20110086376 | In-Vivo Platelet Function Test By Online Bleeding Volume Measurement - A method for remotely determining a patient's excessive bleeding tendency and a patient's resistance to blood thinning medication is disclosed. An incision is made in the patient's forearm. Blood oozing out of the incision is absorbed into a blotter paper until the bleeding stops. Blotches of blood formed on the blotter paper are captured as an image and sent to a service provider who calculates a value associated with the bleeding volume of the patient. The service provider retransmits a value associated with the bleeding volume back to the medical professional. To determine the resistance to blood thinning medication, one incision is made in the patient prior to administration of blood thinning medication. Blood oozing out of the incision is collected on blotter paper until the patient stops bleeding. A second incision is made in the patient. A second set of blotter paper is used to collect the blood oozing out of the incision until the bleeding stops. Both sets of blotter paper are sent to a service provider to calculate a value associated with the difference in bleeding volume. The service provider then retransmits the value associated with the difference in bleeding volume to the medical professional. | 2011-04-14 |
| 20110086377 | Bead Manipulations on a Droplet Actuator - A droplet actuator comprising: (a) a base substrate comprising electrodes configured for conducting droplet operations on a droplet operations surface thereof; (b) a droplet comprising one or more beads situated on the droplet operations surface; (c) a barrier arranged in relation to the droplet and the electrodes such that a droplet may be transported away from the beads using one or more droplet operations mediated by one or more of the electrodes while transport of the beads is restrained by a barrier. Related methods and kits are also provided. | 2011-04-14 |
| 20110086378 | Cartridge For a Biological Sample - An assay device comprising a compartment adapted to receive a sealed removable cartridge, wherein said cartridge is adapted to contain a biologic sample and internally comprises two or more assay locations, wherein said cartridge is adapted to facilitate two or more assays of said biologic sample; and an actuator adapted to interface with said cartridge to transport said biologic sample towards at least one of said assay locations. | 2011-04-14 |
| 20110086379 | Method of Differentiating Stem Cells - The present disclosure provides methods of generating germ layers from stem cells comprising culturing the stem cells in a culture medium having an osmolality less than 340 mOsm/kg. The present disclosure also includes a method to generate different cell lineages from the germ layers as well as to detect them by immunological methods. The present disclosure further provides methods for the generation, isolation, cultivation and propagation of committed progenitor cells and for the production of differentiated cells from the three germ layers. The present disclosure also provides culture media for use in inducing the three germ layers. | 2011-04-14 |
| 20110086380 | DEVICE FOR STORING A BIOLOGICAL SAMPLE AND FOR PREPARING THE BIOLOGICAL SAMPLE - A device for storing a biological sample ( | 2011-04-14 |
| 20110086381 | METHOD FOR EVALUATION OF FUNCTION OF PHAGOCYTE - A novel convenient method for evaluating the function of a phagocyte is provided. The method assays sCD14-ST, which is a humoral factor specifically produced in phagocytosis by the phagocyte and which is stable enough for use in an assay. Also provided is a method for detecting diseases associated with the phagocytosis by the phagocyte. | 2011-04-14 |
| 20110086382 | ORGAN-ON-A-CHIP-DEVICE - A self-contained organ-on-a-chip device includes at least one medium feed reservoir and at least one organ growth section including at least one organ cavity. The at least one medium feed reservoir is configured to connect to the at least one organ growth section by a microfluidic feed channel and the at least one organ cavity. | 2011-04-14 |
| 20110086383 | APPARATUS AND METHODS FOR TREATING ALLOGRAFT PRODUCTS - Apparatus for treating allografts, having a sonication tank configured to transmit ultrasonic energy to the interior of the tank; a treatment canister rotatably positioned in said sonication tank, and configured to receive allografts therein; and a treatment fluid source in fluid communication with said treatment canister. Methods of treating allografts and methods for determining microbial contamination using the apparatus. | 2011-04-14 |
| 20110086384 | IDENTIFICATION OF BACTERIAL SPECIES AND SUBSPECIES USING LIPIDS - The use of free, extractable lipids found in bacteria for identification of bacterial species and subspecies is described. Bacteria have been found to differ sufficiently in their extracted lipid compositions to effect identification using thin layer chromatographic techniques. | 2011-04-14 |
| 20110086385 | PROCESS FOR THE PRODUCTION OF BIOGAS - A container ( | 2011-04-14 |
| 20110086386 | ALGAE BIOMASS FRACTIONATION - A method of fractionating biomass, by permeability conditioning biomass suspended in a pH adjusted solution of at least one water-based polar solvent to form a conditioned biomass, intimately contacting the pH adjusted solution with at least one non-polar solvent, partitioning to obtain an non-polar solvent solution and a polar biomass solution, and recovering cell and cell derived products from the non-polar solvent solution and polar biomass solution. Products recovered from the above method. A method of operating a renewable and sustainable plant for growing and processing algae. | 2011-04-14 |
| 20110086387 | MUTANT NANOARCHAEUM EQUITANS A523R DNA POLYMERASE AND ITS USE - Disclosed herein is a mutant Neq A523R DNA polymerase consisting of an amino acid sequence of SEQ ID NO: 2 wherein alanine at amino acid position 523 in a Nanoarchaeum equitans DNA polymerase (Neq DNA polymerase) consisting of an amino acid sequence of SEQ ID NO: 1 has been substituted with arginine by site-directed mutagenesis. Also disclosed are a gene consisting of a nucleotide sequence encoding the mutant Neq A523R DNA polymerase, a recombinant vector comprising the gene, and a transformant transformed with the vector. In addition, disclosed are a PCR kit comprising the mutant Neq A523R DNA polymerase having excellent performance compared to the wild-type Neq DNA polymerase, and a method for preparing the Neq A523R DNA polymerase. | 2011-04-14 |
| 20110086388 | CHAPERONE-ASSISTED PROTEIN EXPRESSION AND METHODS OF USE - The present disclosure provides methods of utilizing chaperone proteins for the production of active protein such as those encoded by the genes of natural biosynthetic clusters. The methods provided herein have applicability for a wide variety of genes ranging from small fatty acid biosynthetic genes to large non-ribosomal peptide synthetase genes. | 2011-04-14 |
| 20110086389 | Compositions and Methods for Expressing In-Frame Multimeric Proteins - The present invention concerns methods and compositions for making and using multimeric, single chain proteins of a defined structure. In various embodiments the invention involves a bank or collection of one or more monomer nucleic acid species with each such nucleic acid species encoding a protein monomer subunit species and divided into separate subspecies, each bearing a distinct pair of position-specific subcloning restriction endonuclease recognition sites for cassette style cloning into an expression vector and making multimeric, single chain proteins of a defined structure. | 2011-04-14 |
| 20110086390 | Product and Process for Transformation of Thraustochytriales Microorganisms - Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms. | 2011-04-14 |
| 20110086391 | Expression Vector - An expression vector for expressing a target polypeptide in a prokaryotic cell is provided. The vector comprises a promoter operably linked to a polynucleotide encoding the target polypeptide operably linked to a eukaryotic secretion leader sequence, the eukaryotic secretion leader sequence encoding a signal peptide sequence selected from the group consisting of: a) MLKRSSWLATLGLLTVASVSTIVYA; b) MKKATFITCLLAVLLVSNPIWNA; c) MKVSAAALAVILIATALCAPASA; d) MKVSTAFLCLLLTVSAFSAQVLA; and e) MKCLLLALGLALACAAQA. Processes for expressing polypeptides and prokaryotic microorganisms comprising such vectors are also provided. | 2011-04-14 |
| 20110086392 | Methods for Repairing Degraded DNA - The present invention provides methods and kits for repair of degraded DNA which may then be used as a template for efficient amplification by a number of different amplification reactions. The method relies upon a series of enzymatic activities provided by DNA repair enzymes. | 2011-04-14 |
| 20110086393 | METHOD TO PRODUCE SINGLE STRANDED DNA OF DEFINED LENGTH AND SEQUENCE AND DNA PROBES PRODUCED THEREBY - A method for producing a single stranded DNA (ssDNA) molecule of a defined length and sequence is disclosed. This method enables the preparation of, inter alia, probes of greater length than can be chemically synthesized. The method starts with a double stranded molecule, such as genomic, double stranded DNA (dsDNA) from any organism. A fragment of the starting molecule (dsDNA) is amplified by specific primers engineered to introduce cleavage sites on either side of the desired sequence. Cleavage steps on the amplified, engineered fragment are combined with a phosphate removal step, thereby creating a construct that can be digested with an exonuclease without damage to the desired ssDNA. Probes, which hybridize with large gaps between the ends of the probes, are also disclosed. | 2011-04-14 |
| 20110086394 | Nucleic Acid Amplification - The present invention provides methods for the amplification of nucleic acid molecules. Methods for amplifying target polynucleotides, including mRNA, using oligonucleotides, DNA and RNA polymerases are provided. The invention further provides compositions and kits for practicing the methods, as well as methods which use the amplification products. | 2011-04-14 |
| 20110086395 | NOVEL MICROORGANISM AND ITS USE IN LIGNOCELLULOSE DETOXIFICATION - An isolated microorganism is provided which is | 2011-04-14 |
| 20110086396 | D-AMINO ACID OXIDASE, AND METHOD FOR PRODUCTION OF L-AMINO ACID, 2-OXO ACID, OR CYCLIC IMINE - The present invention relates to novel D-amino acid oxidase isolated and purified from | 2011-04-14 |
| 20110086397 | ENHANCED PRODUCTION OF TAXOL AND TAXANES BY CELL CULTURES OF TAXUS SPECIES - This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known | 2011-04-14 |
