12th week of 2016 patent applcation highlights part 25 |
Patent application number | Title | Published |
20160083660 | FCC PROCESS WITH AN INTEGRATED SECONDARY REACTOR FOR INCREASED LIGHT OLEFIN YIELDS - A process for increasing the yields of propylene is presented. The process is an FCC process for producing light olefins, and utilizes a smaller secondary reactor that uses the same catalyst, or a different catalyst as in the FCC reactor. The FCC effluent is separated, and C4 and C5 olefins are recovered. The C4 and C5 olefins are passed to the secondary reactor for cracking to generate increased light olefin yields. | 2016-03-24 |
20160083661 | GASIFIER FOR SOLID CARBON FUEL - Gasifiers for the gasification of solid carbon-based fuels are disclosed herein. An example gasifier includes an inlet chamber for introducing fuel into the gasifier and a pyrolysis region for pyrolyzing the fuel introduced into the vessel. The pyrolysis region includes first means for admission of a pyrolysis agent. The example gasifier also includes a combustion region for incinerating pyrolysis gases originating from the pyrolysis region, where the combustion region includes second means for admission of a gasifying agent. Also, the example gasifier includes a reduction region for gasifying carbonized fuel originating from the pyrolysis region, an outlet for collecting gases originating from the reduction region, and a region for collecting and discharging ashes. In addition, the example gasifier includes active transfer means to actively transfer solid material from the pyrolysis region to the reduction region. In some examples, the active transfer means is located between the pyrolysis region and the combustion region, and the active transfer means includes a transfer chamber to prevent a direct flow of the solid material from the pyrolysis region to the reduction region, where the transfer chamber is permeable to the pyrolysis gases. | 2016-03-24 |
20160083662 | Method for Producing a Synthesis Gas - A method and system are provided for feeding a biomass material feed into a fluidized bed gasifier. The system includes a first plurality of screw conveyors disposed circumferentially around and connected to or integral with a gasifier shell of the fluidized bed gasifier, such that each of the first plurality of screw conveyors is in feed communication with a gasifier chamber defined by the gasifier shell. The system also includes a plurality of secondary receptacles, each individually coupled to a respective screw conveyor of the first plurality of screw conveyors, such that each of the plurality of secondary receptacles includes a secondary receptacle shell defining a secondary receptacle chamber in feed communication with the respective screw conveyor. The system further includes a plurality of primary receptacles, each including a primary receptacle shell defining a primary receptacle chamber in feed communication with at least two of the plurality of secondary receptacles. | 2016-03-24 |
20160083663 | Process for Resourcing Municipal Solid Waste - A process for converting organic MSW into liquid fuels or chemical products in almost quantitative yield via catalytic one-pot hydrolytic depolymerization of organic MSW. The organic MSW comprises all organic materials that exists in municipal solid waste, such as paper and paperboard, food scraps, yard trimmings, rubber, leather, textiles, wood, plastics, etc. The process is the first one over the world for resourcing municipal solid waste. | 2016-03-24 |
20160083664 | Cavitation Generation Ring, Apparatus for Producing Carbon-Based Fuel, and Method for Producing Carbon-Based Fuel - A cavitation generation ring configured to be housed in a part of a liquid communicating pipe, an apparatus for producing carbon-based fuel using the cavitation generation ring, and a production method of carbon-based fuel are disclosed. The production method comprises a petroleum decomposing step for decomposing a molecule of petroleum by cavitation, a water decomposing step for decomposing a molecule of water by cavitation, and a different-molecules composing step for composing the decomposed molecule of petroleum and the decomposed molecule of water by cavitation. | 2016-03-24 |
20160083665 | FUEL ADDITIVE COMPOSITION AND RELATED METHODS - Fuel additive compositions include a plurality of metal nanoparticles and a carrier that is dispersible in a hydrocarbon fuel. The metal nanoparticles can be spherical-shaped and/or coral-shaped metal nanoparticles. The carrier can be liquid, gel or solid and can be readily miscible or soluble in a hydrocarbon fuel such as gasoline, diesel, jet fuel, or fuel oil. The carrier can be a solid carrier configured to allow the hydrocarbon fuel to dissolve the solid carrier in order to release and disperse the metal nanoparticles within the hydrocarbon fuel. | 2016-03-24 |
20160083666 | PROCESS FOR MANUFACTURING A PART PROVIDED WITH A LUBRICATING SURFACE COATING, PART PROVIDED WITH SUCH A COATING AND TURBOMACHINE - A process for manufacturing a part provided with a lubricating surface coating ( | 2016-03-24 |
20160083667 | Lubricating Oil Composition With Enhanced Energy Efficiency - A method for reducing the friction coefficient of a lubricating oil composition in the lubrication of a mechanical device comprises formulating said lubricating oil composition with a carboxylic acid ester obtainable by reacting a mixture comprising at least on dicarboxylic acid and at least one branched C | 2016-03-24 |
20160083668 | Fatty Sorbitan Ester Based Friction Modifiers - A friction modifier composition for reducing friction in a lubricant comprising a fatty acid sorbitan ester that is solid or semi-solid. The fatty acid sorbitan ester is capable of being released into a lubricant at a rate of less than or equal to 0.15 grams per minute. | 2016-03-24 |
20160083669 | FUEL-EFFICIENT ENGINE OIL COMPOSITION - The present invention provides am engine oil composition with excellent fuel saving properties, which comprises a lubricating base oil with a saturate content of 70 percent by mass or more and a viscosity index of 90 or greater and a star polymer as a viscosity index improver in an amount of at least 4 percent by mass or more on the basis of the total mass of the engine oil composition, the ratio (B/A) of (B) the high temperature high shear viscosity at 1×10 | 2016-03-24 |
20160083670 | WATER-SOLUBLE METAL WORKING OIL AGENT - A water-soluble metal working oil agent which can be prevented from being scattered in the form of mists for a long period when used for the cutting processing, grinding processing and the like of metallic materials is provided. A method for producing the water-soluble metal working oil agent is described. The water-soluble metal working oil agent includes a polyalkylene oxide having a weight average molecular weight of 100,000 to 1,000,000 and water. | 2016-03-24 |
20160083671 | POLYALKYLENE GLYCOL-BASED INDUSTRIAL LUBRICANT COMPOSITIONS - A lubricant composition comprises as a lubricant base, an oil soluble polyalkylene glycol suitable for use as a lubricant in an industrial oil, grease or metal working fluid; and an additive comprising (1) alkylated phenyl-α-naphthylamine; and (2) 2,2,4-trialkyl-1,2-dihydroquinoline. | 2016-03-24 |
20160083672 | LUBRICATING OIL COMPOSITION FOR REFRIGERATORS - Provided is a lubricating oil composition for a refrigerator which uses a base oil including as the main component at least one kind of oxygen-containing compounds selected from polyoxyalkylene glycols, polyvinyl ethers, copolymers of poly(oxy)alkylene glycols or monoethers thereof and polyvinyl ethers, polyol esters, and polycarbonates. The lubricating oil composition for a refrigerator is used for a refrigerator that uses, as a refrigerant, a fluorine-containing organic compound, which is a refrigerant applicable to current car air conditioner systems or the like and has a specific polar structure, and has favorable sealing property, a low coefficient of friction factor in a sliding part, and excellent stability as well as excellent compatibility with the refrigerant. | 2016-03-24 |
20160083673 | METHODS FOR PRODUCING OIL FORMULATIONS BY MEANS OF CERTAIN CARBODIIMIDES - The present invention relates to a novel method for preparing stabilised oil formulations by means of certain carbodiimides. | 2016-03-24 |
20160083674 | ENZYME BASED PRODUCTS FOR CAR WASHES - The present invention relates to a liquid composition soluble in water or other polar substance and its use for vehicle cleansing and care, in particular for all the treatments provided in the washing steps of vehicles. The composition comprises at least one active enzymatic component. | 2016-03-24 |
20160083675 | CLEANING LIQUID COMPOSITION - The purpose of the present invention is to provide a cleaning liquid composition useful in cleaning substrates, etc., which have undergone treatment such as chemical mechanical polishing (CMP) in a process for manufacturing electronic devices such as semiconductor elements. This cleaning liquid composition for cleaning substrates having Cu wiring includes one or more basic compounds and one or more heteromonocyclic aromatic compounds containing a nitrogen atom, and has a hydrogen ion concentration (pH) of 8-11. | 2016-03-24 |
20160083676 | METHOD AND APPARATUS FOR HIGH EFFICIENCY POST CMP CLEAN USING ENGINEERED VISCOUS FLUID - Embodiments of the present apparatus and methods for post CMP clean. More particularly, embodiments provide apparatus and methods for removing nano sized particles. One embodiment provides a method for cleaning a substrate. The method includes exposing the substrate to a viscoelastic fluid to remove small particles from the substrate. The viscoelastic fluid comprising a viscosity adjustor and an aqueous base. | 2016-03-24 |
20160083677 | STRUCTURED DETERGENT PARTICLES AND GRANULAR DETERGENT COMPOSITIONS CONTAINING THE SAME - This relates to structured detergent particles with mid-level surfactant activity, which contain 35-50 wt % of a C | 2016-03-24 |
20160083678 | DEVICE AND METHOD FOR HEATING A FERMENTABLE STARTING MATERIAL FOR BEVERAGE PRODUCTION - A device and a method for heating a fermentable starting material for beverage production wherein a heat transporting medium is transported in a heat transporting medium circuit in a first flow direction via a heat storage device for storing/emitting heat, a heating medium for heating the heat transporting medium, and a heat emission chamber in which the heat is transferred from the heat transporting medium to the fermentable starting material flowing in a line. | 2016-03-24 |
20160083679 | PHOTO-BIOREACTOR SYSTEM AND METHOD FOR PRODUCTION OF BIO-MATERIALS - A photo-bioreactor and method of operating are described. The photo-bioreactor includes a reactor vessel arranged to contain a fluid medium within which bio-material is grown, and at least one light-emitting rod extending into the reactor vessel, wherein the light-emitting rod has an elongate tubular member characterized by a length along a longitudinal axis and a width along an axis normal to the longitudinal axis, and designed with an outer wall that encloses one or more light-emitting devices arranged along the longitudinal axis, the outer wall being transparent to at least part of the light emitted by the one or more light-emitting devices into the reactor vessel. The photo-bioreactor further includes a drive system coupled to the elongate tubular member, and operatively configured to rotate the light-emitting rod about the longitudinal axis within reactor vessel, and circulate the fluid medium through the reactor. | 2016-03-24 |
20160083680 | BIOMATERIAL HANDLING DEVICE - A biomaterial handling device is described that will provide for functionality for performing both IVF procedures and washing techniques in a single device. Disclosed embodiments provide increased protection to biomaterial samples during processing and handling. Embodiments of the invention reduce labor intensive processes for both IVF and washing treatments and address reduced risks of contamination of biological samples by providing an increasingly sterile environment. | 2016-03-24 |
20160083681 | AUTOMATED CELL AND TISSUE BIOPRINTER - The present invention are directed to a novel automated cell bioprinter and related methods for making three-dimensional tissue constructs with spatial organization of cells that provides: (i) organized cell placement and spatial assembly of multiple cell types in a reproducible manner (ii) direct and non-contact assembly of multiple cell types and/or cell layers without exerting damaging forces on the cells or tissues, (iii) retention of cell viability and functionality during assembly steps and long periods of culture, (iv) minimal use of harmful and toxic chemicals such as profuse amounts of mineral oil and buffer reagent, and (v) efficient layer-to-layer assembly of cell layers within the three-dimensional construct while (vi) avoiding the use of complicated surface treatments that prevents scale-up, and (vii) avoiding mutation-inducing radiations such as UV used to photocrosslink hydrogels. | 2016-03-24 |
20160083682 | Unitary 3D Culture Device - A continuous device for culturing mammalian cells in a three-dimensional structure for the transplantation or implantation in vivo is described. The culturing device comprises (a) a scaffold formed by a matrix of interconnected growth surfaces spaced at regular intervals and (b) a fluid distribution means at the inlet and the exit of the growth areas. The device is particularly useful for culturing bone cells for dental implants or bone reconstruction. | 2016-03-24 |
20160083683 | Anaerobic Digester System - Embodiments provide a bioreactor system for the bioconversion of biomass into products and renewable energy, and a method for the same. | 2016-03-24 |
20160083684 | ETHANOL PRODUCTION DEVICE AND PROCESS THROUGH CONTINUOUS SOLID-STATE FERMENTATION AND HAVING SELF-CONTROL SYSTEM - The present invention belongs to the technology field of microbial fermentation for producing fuel ethanol. It specifically relates to a device and process having self-control system for producing fuel ethanol. The process mainly comprises the two steps of strain addition and continuous solid-state fermentation, that is, adding the fermentation bacterial strains into crushed raw materials before the crushed materials entering into the continuous solid-state fermentation tank and then the above materials mixed with bacteria are fermented in the continuous solid-state fermentation tank, making the fermentable sugars into ethanol. | 2016-03-24 |
20160083685 | HARVESTING AND PURIFICATION OR PERFUSION YIELDER (HAPPY) DEVICE - A modular device comprising one or more porous substrate subunits comprising a binding substrate that is capable of interacting with a target biological product, either during, or at the end of a manufacturing cycle; and methods of using the device to harvest or purify a biological product. | 2016-03-24 |
20160083686 | DEVICE AND METHOD FOR AUTOMATIC PROCESSING OF CULTURE PLATES FOR MICROBIOLOGICAL SAMPLES - An automatic processing device of culture plates ( | 2016-03-24 |
20160083687 | METHOD AND DEVICE - The present invention relates to a method for the deformation and/or fragmentation of a cell, spore or virus, the method comprising: (i) bringing a liquid sample containing the cell, spore or virus into contact with a first surface of a vibratable plate having at least one aperture, and causing the plate to vibrate; and (ii) passing the sample of the cell, spore or virus through the at least one aperture in the vibrating plate so as to cause deformation and/or fragmentation of the cell, spore or virus. It also concerns a device for carrying out the method. | 2016-03-24 |
20160083688 | IMPROVED METHODS FOR MAKING RIBOSOMES - A platform for preparing a sequence defined biopolymer in vitro is disclosed. The platform includes a ribosome-depleted cellular extract ribosomal RNAs prepared by in vitro transcription and purified ribosomal proteins depleted of ribosomal RNAs. A method of synthesizing and assembling ribosomes in vitro for use in the platform is provided, as well as a method for preparing a sequence defined biopolymer in vitro using assembling ribosomes and the platform. | 2016-03-24 |
20160083689 | ANIMAL PROTEIN-FREE MEDIA FOR CULTIVATION OF CELLS - The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes. | 2016-03-24 |
20160083690 | MICROCARRIERS FOR STEM CELL CULTURE AND FABRICATION THEREOF - A method for manufacturing polycaprolactone microcarriers is disclosed together with uses of the microcarriers. | 2016-03-24 |
20160083691 | SYSTEMS AND METHODS FOR PROCESSING CELLS - The present invention efficiently and cost-effectively extracts and collects cells from a tissue. The inventors have discovered that the tissue can be effectively fragmented and the resulting cells can be purified using a system or kit with multiple components. An advantage of the present invention is that tissue processing takes place in a closed system such that sterility can be maintained throughout the process, even if certain components are removed during processing, for example through the use of valves, clamps, and heat seals. Furthermore, any or all of the steps can be automated or manually accomplished, according to the specific needs of the application or the user. | 2016-03-24 |
20160083692 | ELECTROACTIVE POLYMERIC SCAFFOLDS AND METHOD FOR DELIVERING NERVE GROWTH FACTOR TO NERVE TISSUE - A polymerizable unit that yields an electrochemically responsive polymer (advantageously pyrrole) is anchored by polymerization within a polycaprolactone matrix to form an electroactive scaffold upon which cells can be cultured and in which the micro- and nano-topological features of the polycaprolactone matrix are preserved. A scaffold manufactured in accordance with the preferred embodiment can support Schwann cells, which produce nerve growth factor when electrically stimulated. Nerve growth factor has been demonstrated to promote the regeneration of nerve tissue. By implanting the scaffold on which Schwann cells have been cultured into damaged nerve tissue and applying a voltage across the scaffold, nerve growth factor is produced, thereby promoting repair of the damaged nerve tissue. | 2016-03-24 |
20160083693 | COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO CELL POPULATIONS COMPRISING BETA-LIKE CELLS - Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells. | 2016-03-24 |
20160083694 | COMPOSITIONS AND METHODS TO PREVENT AAV VECTOR AGGREGATION - Compositions and methods are provided for preparation of concentrated stock solutions of AAV virions without aggregation. Formulations for AAV preparation and storage are high ionic strength solutions (e.g. μ˜500 mM) that are nonetheless isotonic with the intended target tissue. This combination of high ionic strength and modest osmolarity is achieved using salts of high valency, such as sodium citrate. AAV stock solutions up to 6.4×10 | 2016-03-24 |
20160083695 | NOVEL BACTERIOPHAGE AND ANTIBACTERIAL COMPOSITION COMPRISING THE SAME - Provided is a novel bacteriophage ΦCJ23 (KCCM11365P). In addition, the present invention relates to an antibacterial composition including the bacteriophage ΦCJ23 (KCCM11365P) as an active ingredient. Further, provided is a method of preventing and/or treating infectious diseases by avian pathogenic | 2016-03-24 |
20160083696 | NOVEL BACTERIOPHAGE AND ANTIBACTERIAL COMPOSITION COMPRISING THE SAME - Provided is a novel bacteriophage ΦCJ20 (KCCM11362P). In addition, the present invention relates to an antibacterial composition including the bacteriophage ΦCJ20 (KCCM11362P) as an active ingredient. Further, the present invention is a method of preventing and/or treating infectious diseases by enterotoxigenic | 2016-03-24 |
20160083697 | NOVEL BACTERIOPHAGE AND ANTIBACTERIAL COMPOSITION COMPRISING THE SAME - Provided is a novel bacteriophage ΦCJ20 (KCCM11362P). In addition, the present invention relates to an antibacterial composition including the bacteriophage ΦCJ20 (KCCM11362P) as an active ingredient. Further, the present invention is a method of preventing and/or treating infectious diseases by enterotoxigenic | 2016-03-24 |
20160083698 | LONE STAR VIRUS - This disclosure concerns the isolation, identification and sequencing of a unique | 2016-03-24 |
20160083699 | HIGH EFFICIENCY FLP SITE-SPECIFIC RECOMBINATION IN MAMMALIAN CELLS USING AN OPTIMIZED FLP GENE - The present invention provides an optimized FLP site-specific recombinase coding sequence and methods for its use. This genetically engineered FLP gene displays a marked increase in recombination efficiency compared to the native FLP gene and is therefore useful in a wide array of molecular applications. | 2016-03-24 |
20160083700 | PHYTASE - Polypeptides having phytase activity and polynucleotide sequences encoding the phytases are provided. The gene expresses the phytase at a level of at least 7 g/L to 40 g/L. The phytase have higher specific activity, retain activity at low pH, and retain activity at high temperature. The phytase can be used in a variety of compositions including food, feed, pharmaceuticals, and cleaning. | 2016-03-24 |
20160083701 | METHODS FOR MODULATING CYCLIC NUCLEOTIDE-MEDIATED SIGNALING IN CARDIAC MYOCYTES AND COMPOSITIONS - The invention provides a polypeptide possessing anti-hypertrophic activity in a cardiac myocyte, wherein the polypeptide is a mutant variant derived from wild-type PDE3A1 protein and wherein the wild-type PDE3A1 protein has the amino acid sequence given in SEQ ID NO:1 at amino acid position 146 to 1141. | 2016-03-24 |
20160083702 | NOVEL PHOSPHOTRIESTERASE ENZYMES, METHODS AND COMPOSITIONS RELATED THERETO - The instant invention provides methods and related compositions for identifying polypeptides with improved stability and/or enzymatic activity in comparison to native forms, wherein the identified polypeptides comprise one or more non-natural amino acids. In certain embodiments, the present invention relates to novel phosphotriesterase enzymes comprising one or more non-natural amino acids. In a particular embodiment, the instant invention provides novel phosphotriesterase enzymes with greater stability and/or enhanced activity in comparison to native forms of the enzyme. The present invention also relates to compositions comprising novel phophotriesterase enzymes, such as prophylactics, decontaminants, animal feedstocks, and assay kits. | 2016-03-24 |
20160083703 | POLYPEPTIDES HAVING ALPHA AMYLASE ACTIVITY - The present invention relates to polypeptides having alpha-amylase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2016-03-24 |
20160083704 | POLYPEPTIDES HAVING ALPHA AMYLASE ACTIVITY - The present invention relates to polypeptides having alpha-amylaseactivity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2016-03-24 |
20160083705 | ENZYME COMPOSITIONS FOR THE IMPROVEMENT OF FERMENTATION PROCESSES AND BY-PRODUCTS - The present technology relates to novel enzyme compositions for the use in processes of producing a fermentation product, in particular ethanol. The use of the disclosed enzyme composition results in improving the quality of by-products in the fermentative production process since they are capable of optimal degrading components in the fermented mash in the fermentation process. | 2016-03-24 |
20160083706 | BORONATE-MEDIATED DELIVERY OF MOLECULES INTO CELLS - Cargo molecules carrying one or more phenylboronate moieties useful for cellular uptake of the cargo molecules. Phenylboronate can be ligated, crosslinked or otherwise bonded to the cargo molecules. Cargo molecules include peptides and proteins. The phenylboronate groups are optionally conjugated to the cargo molecule via linking moieties that can be selectively cleaved, such cleavable linkers can allow the phenylboronate groups to be removed from the cargo molecule after the boronated cargo molecule is introduced into the cell. The invention includes certain phenylboronates which are boronation reagents, certain boronated oligopeptides and certain boronated peptides and proteins. The invention also includes kits for enhancing cellular uptake of cargo molecules by boronation with one or more phenylboronates or boronated oligopeptides. | 2016-03-24 |
20160083707 | PLANT LECTINS AS CARRIERS OF ASSOCIATED DRUG SUBSTANCES INTO ANIMAL AND HUMAN CELLS - The current invention involves the use of protein lectins produced by plants including the non-toxic carbohydrate binding subunits (B subunits) of plant “AB toxins” (PTB lectins) as delivery vehicles for mobilizing associated drug substances for delivery to animal and human cells. The resulting protein fusions or conjugates retain lectin carbohydrate specificity for binding to cells and cellular trafficking activity so as to deliver an associated drug compound to the site of disease manifestation. One embodiment of this invention concerns the ability of ricin toxin B subunit, as a model PTB lectin, to deliver enzyme replacement therapeutic drugs to cells of several organs of the body including the brain and central nervous system, eyes, ears, lungs, bone, heart, kidney, liver, and spleen for treating lysosomal diseases. | 2016-03-24 |
20160083708 | COLD-ADAPTED PROTEASE DERIVED FROM PSEUDOALTEROMONAS ARCTICA PAMC 21717 AND USES THEREOF - A cold-adapted protease derived from | 2016-03-24 |
20160083709 | COLD-ADAPTED PROTEASE DERIVED FROM PSEUDOALTEROMONAS ARCTICA PAMC 21717 AND USES THEREOF - A cold-adapted protease derived from | 2016-03-24 |
20160083710 | COMPOSITIONS AND METHODS COMPRISING PROTEASE VARIANTS - The present invention provides protease variants, compositions comprising protease variants, and methods of using such protease variants and compositions. | 2016-03-24 |
20160083711 | ASPARTIC PROTEASES - The invention relates to aspartic proteases, and particularly to aspartic proteases for plants. Disclosed are modified plant aspartic proteases, and methods for their manufacture, and uses thereof. Particularly contemplated are the uses of aspartic proteases in clotting milk. | 2016-03-24 |
20160083712 | CSN5 POLYPEPTIDES AND USES THEREOF FOR SCREENING THERAPEUTIC AGENTS - The present invention relates to mutated CSN5 polypeptides and their use in a method of screening modulators of CSN5 activity that could be used as therapeutic agents. | 2016-03-24 |
20160083713 | NOVEL PEPTIDYL ALPHA-HYDROXYGLYCINE ALPHA-AMIDATING LYASES - The present patent application concerns an enzyme capable of catalysing the conversion of a α-hydroxyglycine to an α-amide and the use of such enzymes for producing a C-terminal α-amidated peptide. | 2016-03-24 |
20160083714 | MUTANT CYAA POLYPEPTIDES AND POLYPEPTIDE DERIVATIVES SUITABLE FOR THE DELIVERY OF IMMUNOGENIC MOLECULES INTO A CELL - The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host. The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin. | 2016-03-24 |
20160083715 | ELECTRONIC EXPRESSION OF THE INWARD RECTIFIER IN CARDIOCYTES DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS - Systems and methods are provided for improving action potential morphology in iPSC-derived cardiac myocytes and utilizing such myocytes. Improved morphology may include, for example, physiological resting membrane potentials. Membrane voltages of the myocyte are measured and a synthetic inward rectifying current is applied to the myocyte based on the membrane voltage. | 2016-03-24 |
20160083716 | Highly Simplified Lateral Flow-Based Nucleic Acid Sample Preparation and Passive Fluid Flow Control - Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays. | 2016-03-24 |
20160083717 | ANTIGEN SCREENING SYSTEM - Methods and compositions for identifying antigens of human lymphocytes are provided herein. | 2016-03-24 |
20160083718 | EXPANDED RADIX FOR POLYMERIC TAGS - A method having steps of (a) providing nucleic acids having a tag sequence (N | 2016-03-24 |
20160083719 | Method for Producing Compound Containing Heterocycle - An object of the present invention is to provide a method of stably introducing a heterocycle into a substrate peptide by using an azoline backbone introducing enzyme. | 2016-03-24 |
20160083720 | METHOD FOR THE SYNTHESIS OF A BIFUNCTIONAL COMPLEX - Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes. | 2016-03-24 |
20160083721 | MULTIPLEXED SEQUENTIAL LIGATION-BASED DETECTION OF GENETIC VARIANTS - The present invention provides multiplexed sequential ligation-based analysis of genetic variants in a mixed sample, including copy number variations and single nucleotide polymorphisms. The invention employs the techniques of sequential ligation and amplification. | 2016-03-24 |
20160083722 | COMPOSABILITY AND DESIGN OF PARTS FOR LARGE-SCALE PATHWAY ENGINEERING IN YEAST - Expression cassettes comprising promoter and terminator combinations are provided and can be used to tune gene expression. Synthetic yeast promoters and methods of making them also are provided. | 2016-03-24 |
20160083723 | USE OF POST-TRANSCRIPTIONAL GENE SILENCING FOR IDENTIFYING NUCLEIC ACID SEQUENCES THAT MODULATE THE FUNCTION OF A CELL - Described herein are methods for identifying nucleic acid sequences that modulate the function of a cell, the expression of a gene in a cell, or the biological activity of a target polypeptide in a cell. The methods involve the use of double stranded RNA expression libraries, double stranded RNA molecules, and post-transcriptional gene silencing techniques. | 2016-03-24 |
20160083724 | METHODS FOR SAMPLE PREPARATION - The disclosure provides for single amplification and double amplification methods for preparing nucleic acid samples for sequencing. | 2016-03-24 |
20160083725 | PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR INFLAMMATORY DISEASE, AND METHOD FOR SCREENING PROPHYLACTIC AND/OR THERAPEUTIC DRUG FOR INFLAMMATORY DISEASE - Provided are a novel prophylactic and/or therapeutic drug for an inflammatory disease and a method for searching for the same. | 2016-03-24 |
20160083726 | Compositions and Methods for the Treatment of Parkinson Disease by the Selective Delivery of Oligonucleotide Molecules to Specific Neuron Types - The invention provides a conjugate comprising (i) a selectivity agent which binds specifically to one or more neurotransmitter transporters selected from the group consisting of a dopamine transporter (DAT), serotonin transporter (SERT) or a norepinephrine transporter (NET) and (ii) a nucleic acid capable of specifically binding to a target molecule which is expressed in the same cell as the neurotransmitter transporter wherein said target molecule is α-synuclein or the mRNA encoding α-synuclein. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interest and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of imaging agents to the cells for diagnostic purposes. | 2016-03-24 |
20160083727 | MIRNA FOR REGULATING FABP6 GENE AND METHOD OF USING THE SAME - A molecular marker miRNA for sheep breeding. The target gene of the miRNA is FABP6, and the miRNA inhibits the expression of the gene FABP6 in the adipose tissue of sheep. | 2016-03-24 |
20160083728 | Methods and Compositions for Enhancing the Therapeutic Effect of Anti-Tumor T Cells - Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of Forkhead Box protein 1 (Foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of Forkhead Box protein 1 (Foxp1) expression, viral vectors containing such molecules, T cells transduced with these viruses for adoptive therapies, and any small molecules that bind to and inactivate Foxp1. These compounds and methods have applications in cancer therapy either alone or in combination with other therapies that stimulate the endogenous immune system in the environment of the cancer, e.g., tumor. | 2016-03-24 |
20160083729 | PHASE CHANGING FORMULATIONS OF NUCLEIC ACID PAYLOADS - The present invention is based, at least in part, upon discovery of a process for identifying phase changing peptides. Such phase changing peptides are capable of enhancing in vitro and in vivo delivery of oligonucleotides (e.g., dsRNAs) in lipidic, vesicular, micellar and/or naked oligonucleotide formulations. | 2016-03-24 |
20160083730 | SYSTEMS COMPRISING NON-IMMUNOGENIC AND NUCLEASE RESISTANT NUCLEIC ACID ORIGAMI DEVICES FOR MOLECULAR COMPUTATION - Systems acting as logic gates and systems exhibiting quorum sensing are provided, wherein said systems comprise at least one effector nucleic acid origami device, at least one regulator nucleic acid origami device, at least one input and at least one output, and the nucleic acid origami devices are non-immunogenic and/or resistant to nucleases. | 2016-03-24 |
20160083731 | APTAMER-RNAi THERAPEUTIC COMPOSITIONS - A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of RORγ2 is described herein. Pharmaceutical compositions comprising the recombinant nucleic acid, particularly topical compositions are also described. Methods of treating inflammatory disease using the pharmaceutical composition are also described. | 2016-03-24 |
20160083732 | SYNTHETIC LETHALITY IN CANCER - There is described herein compounds, compositions and methods for inducing synthetic lethality in a cancer cell(s). | 2016-03-24 |
20160083733 | NOVEL TREATMENT OF METABOLIC DISEASES - Antagonists of Mammalian Sterile 20-like kinase (MST) 1 for use in the treatment and prevention of metabolic diseases, in particular diabetes and obesity are described. | 2016-03-24 |
20160083734 | COMPOSITIONS AND METHODS FOR TREATING CANCER - A method of one or more of, inhibiting motility, migration, dispersal, and metastasis of a cell that expresses an RPTP, which is proteolytically cleaved to form intracellular fragments in the cell includes administering to the cell an amount of an agent effective to inhibit one or more of the catalytic activity and function of the proteolytically cleaved intracellular domain-containing fragments of the RPTP. | 2016-03-24 |
20160083735 | PROMOTER - The current invention reports a promoter having the nucleic acid sequence of SEQ ID NO: 02, or SEQ ID NO: 03, or SEQ ID NO: 04, or SEQ ID NO: 06, which is a 5′ shortened SV40 promoter with reduced promoter strength especially useful for the limited expression of heterologous polypeptides or selectable markers. | 2016-03-24 |
20160083736 | METHOD OF ASSEMBLING MULTI-FRAGMENT DNA MOLECULE AND USE THEREOF - A method of assembling multi-fragment DNA molecule, the method including: 1) constructing a vector system including an acceptor vector A1, a first donor vector B1, and a second donor vector B2, and each of the acceptor vector A1, the second donor vector B2, and the second donor vector B2 including a multiple cloning site; 2) introducing a first target sequence L | 2016-03-24 |
20160083737 | AGROBACTERIUM BACTERIUM TO BE USED IN PLANT TRANSFORMATION METHOD - This invention relates to the | 2016-03-24 |
20160083738 | PRODUCTION OF BACTERIAL MICROCOMPARTMENTS IN EUKARYOTIC CELLS - The invention relates to eukaryotic organisms such as vascular plants that include recombinant microcompartments. | 2016-03-24 |
20160083739 | METHOD FOR MODULATING EXPRESSION OF SPECIFIC PROTEIN USING SPECIFIC TRANSCRIPTION FACTOR, ISOPRENOID-PRODUCING PLANT HAVING TRANSGENE ENCODING SPECIFIC TRANSCRIPTION FACTOR, AND METHOD FOR PRODUCING POLYISOPRENOID USING ISOPRENOID-PRODUCING PLANT - The present invention provides methods for enhancing the polyisoprenoid biosynthesis pathway. The present invention further provides isoprenoid-producing plants having an enhanced polyisoprenoid biosynthesis pathway, and methods for producing a polyisoprenoid using such an isoprenoid-producing plant. The present invention relates to methods for regulating the expression of specific protein(s) by a specific transcription factor; isoprenoid-producing plants into which has been introduced a gene encoding a specific transcription factor; and methods for producing a polyisoprenoid using such an isoprenoid-producing plant. | 2016-03-24 |
20160083740 | PLANT REGULATORY ELEMENTS AND USES THEREOF - The invention provides recombinant DNA molecules and constructs, as well as their nucleotide sequences, useful for modulating gene expression in plants. The invention also provides transgenic plants, plant cells, plant parts, and seeds comprising a recombinant DNA molecule comprising a DNA molecule operably linked to heterologous transcribable DNA molecule, as are methods of their use. | 2016-03-24 |
20160083741 | Increasing the Content of Long Chain Fatty Acids in Seed Oil - Provided are plants that express, or overexpress, a pPLAIIIδ protein. Constitutive or seed-specific expression of pPLAIIIδ protein in | 2016-03-24 |
20160083742 | Modified Plants for Producing Aroma/Fine/Specialty Chemicals - The present disclosure describes genetically modified plants that contain one or more exogenous genes associated with aroma/fine/specialty compound biosynthesis, which are capable of producing aroma/fine/specialty compounds. | 2016-03-24 |
20160083743 | PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME - The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a FSM1-like (Fruit Sant/Myb) polypeptide, or a PIF3-like (PHYTOCHROME INTERACTING FACTOR) polypeptide, or an Uroporphyrinogen III decarboxylase (UROD) polypeptide, or an AS-MTT (Abiotic Stress Membrane Tethered Transcription factor) polypeptide, or an EXO-1 polypeptide, or a YiAP2 (Yield increasing Apetala 2) polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a FSM1-like polypeptide, which plants have enhanced yield-related traits relative to corresponding wild type plants or other control plants. The invention also provides constructs useful in the methods of the invention. | 2016-03-24 |
20160083744 | METHOD FOR SPEEDING UP PLANT GROWTH AND IMPROVING YIELD BY ALTERING EXPRESSION LEVELS OF KINASES AND PHOSPHATASES - Transgenic plants having increased growth rate and increase yield are disclosed, and methods for making the same. In one embodiment, the method comprises: transforming a plant or plant cell with a nucleic acid molecule comprising a plant kinase and/or phosphatase gene selected from NG6, NG21, NG24, NG28, and NG32, and over-expressing said kinase and/or phosphatase gene in the plant or plant cell. | 2016-03-24 |
20160083745 | MATERIALS AND METHOD FOR INCREASING A PLANT'S RESISTANCE TO STRESS - Method of increasing resistance to a pathogen or a pest in a plant comprising introducing into the plant and expressing therein a polynucleotide comprising a nucleotide sequence encoding a Qua-Quine Starch (QQS) polypeptide; method of producing a plant with increased resistance to a pathogen or a pest comprising crossing a plant obtained in accordance with the above method with a second plant to produce progeny plants and selecting progeny plants with increased resistance to a pathogen or a pest; a plant with increased resistance to a pathogen or a pest; a seed of the plant; a hybrid of the plant; and a seed of the hybrid plant. | 2016-03-24 |
20160083746 | METHODS AND COMPOSITIONS FOR TARGETED GENE MODIFICATION - Disclosed herein are methods and compositions for gene targeting utilizing fusion molecules comprising a recombinase domain and a sequence-specific DNA-binding domain. | 2016-03-24 |
20160083747 | INTRACELLULAR TRANSLATION OF CIRCULAR RNA - A circular mRNA molecule possessing features resembling native mammalian mRNA demonstrates improved translation, while retaining the properties of an extremely long half-life inside cells. This circular mRNA is functional inside mammalian cells, being able to compete against native cellular mRNAs for the eukaryotic translation initiation machinery. The invention possesses additional RNA elements compared to a previous invention containing only an IRES element for successful in vitro or in vivo translation. | 2016-03-24 |
20160083748 | TISSUE PREFERENTIAL CODON MODIFIED EXPRESSION CASSETTES, VECTORS CONTAINING SAME, AND USES THEREOF - Described herein are synonymously altered gene sequences which express protein in differing levels within secretory as compared to non-secretory target tissue. An expression cassette comprising an open reading frame (ORF) for a protein under the control of regulatory sequences which direct expression of the product in cell, which ORF has been modified to preferentially increase expression levels in a selected tissue, wherein the modified ORF is characterized by a triplet frequency of any one of Tables 3-12, 16 or 17. | 2016-03-24 |
20160083749 | SUBFAMILY E SIMIAN ADENOVIRUSES A1302, A1320, A1331 AND A1337 AND USES THEREOF - Recombinant vectors comprise simian adenovirus A1302 (SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. | 2016-03-24 |
20160083750 | Microbial derived isoprene and methods for making the same - Provided herein is a gaseous isoprene composition comprising isoprene, carbon dioxide and water, wherein the isoprene is in an amount between about 0.1% and about 15% by volume; wherein the carbon dioxide is in an amount between about 0.04% and about 35% by volume; wherein the water is in an amount greater than about 70% of its saturation amount. Also provided herein is a liquid isoprene composition comprising isoprene in an amount of at least 65% by weight and carbon dioxide in an amount between about 0.01% and about 1% by weight. | 2016-03-24 |
20160083751 | METHOD FOR PRODUCING ALDEHYDE FROM CO2 - The invention provides recombinant microorganisms capable of producing isobutyraldehyde using CO | 2016-03-24 |
20160083752 | MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING SUCCINATE RELATED THERETO - Provided herein is a non-naturally occurring microbial organism (NNOMO) having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as succinate. Also provided herein are methods for using such an organism to produce succinate. | 2016-03-24 |
20160083753 | METABOLIC EVOLUTION OF ESCHERICHIA COLI STRAINS THAT PRODUCE ORGANIC ACIDS - This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids. | 2016-03-24 |
20160083754 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as poly carboxylic acids and poly carboxylic acid derivatives. | 2016-03-24 |
20160083755 | CLOSTRIDIUM CADAVERIS STRAIN AND USES OF THE SAME - An isolated | 2016-03-24 |
20160083756 | PROCESS FOR PRODUCING AN ORGANIC COMPOUND - A process of producing an organic compound and/or an intermediary compound includes feeding carbon dioxide to a culture of Cyanobacteria cells and subjecting the culture to light, wherein the cells are capable of expressing a nucleic acid molecule that confers the ability to convert a glycolytic intermediate into said organic/intermediary compound. The expression of the nucleic acid molecule is under the control of a regulatory system which responds to a change in the concentration of a nutrient in the culture. | 2016-03-24 |
20160083757 | ENZYMATIC PROCESS FOR THE PRODUCTION OF MANNOSYLERYTHRITOL LIPIDS FROM LIGNOCELLULOSIC MATERIALS - The present invention relates to processes for the production of microbial glycolipids, mannosylerythritol lipids (MEL), from lignocellulosic carbon source. These processes are characterized in that the use of lignocellulosic materials for the production of a microbial glycolipids, MEL, comprising a fermentation preferably using fungi of the genus | 2016-03-24 |
20160083758 | ACYL-ACP THIOESTERASES AND MUTANTS THEREOF - Novel plant acyl-ACP thioesterase genes of the FatB and FatA classes and proteins encoded by these genes are disclosed. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Expression of the novel and/or mutated FATB and FATA genes is demonstrated in oleaginous microalga host cells. Furthermore, a method for producing an oil elevated in one or more of C12:0, C14:0, C16:0, C18:0 and/or C18:1 fatty acids includes transforming a cell with novel and/or mutated FATB and/or FATA genes, e.g., having an N-terminal deletion. The cells produce triglycerides with altered and useful fatty acid profiles. | 2016-03-24 |
20160083759 | ENGINEERED KETOREDUCTASE POLYPEPTIDES - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine. | 2016-03-24 |