11th week of 2011 patent applcation highlights part 39 |
Patent application number | Title | Published |
20110065075 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF FACIAL EMOTION SENSITIVITY - A method is presented to address quantitative assessment of facial emotion sensitivity of a subject, where the method comprises the steps of: (1) presenting at least one scene to the subject on a display, the scene comprising a plurality of faces and a background on a display, the plurality of faces comprising a plurality of facial expressions; (2) adjusting at least one facial expression on the scene; (3) receiving feedback from said subject via at least one input device; (4) quantitatively refining the received feedback; (5) modulating the adjusted facial expression relative to the accuracy of the received feedback; (6) (7) transforming the modulated facial expression; (8) calculating a critical threshold parameter; and (9) recording a critical threshold parameter onto a tangible computer readable medium. An apparatus for quantitative assessment of facial emotion sensitivity of a subject comprising a display device, an input device, a control device, and a tangible computer readable medium. In its simplest sense, a quantitative assessment profile of facial emotion sensitivity by psychophysical responses is generated on a tangible computer readable medium. | 2011-03-17 |
20110065076 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF SOCIAL CUES SENSITIVITY - A method is presented to address quantitative assessment of social cues sensitivity of a subject, where the method comprises the steps of: ( | 2011-03-17 |
20110065077 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF SPATIAL SEQUENCE MEMORY - A method is presented to address quantitative assessment of spatial sequence memory in a subject, where the method comprises the steps of: ( | 2011-03-17 |
20110065078 | METHOD AND SYSTEM FOR QUANTITATIVE ASSESSMENT OF SOCIAL INTERACTIONS NULLING TESTING - A method is presented to address quantitative assessment of social interactions nulling testing of a subject, where the method comprises the steps of: ( | 2011-03-17 |
20110065079 | METHOD USING EXERCISE TO RANDOMLY IDENTIFY CHAPTERS IN THE BIBLE FOR STUDY - A method for randomly identifying a chapter in the Bible from the number of repetitions of a physiological action that occurs during exercise. A physiological measuring device is attached to one or more body parts and the numerical cumulative occurrence of one or more physiological actions are recorded on the physiological measuring device over a period of time. A number is obtained having a sequence of three or more numerical digits reflecting the numerical cumulative occurrence from the physiological measuring device. One or more of the numerical digits are then selected randomly to identify a book in the Bible, and one or more of the numerical digits are selected randomly to identify a chapter in the identified book of the Bible. | 2011-03-17 |
20110065080 | TV-BASED KARAOKE - Combination of TV and karaoke machine allows for a new method of obtaining karaoke songs from the Internet, storing them locally at the TV, and subsequently playing audio of the song mixed with a singer's voice inputted through a USB microphone. | 2011-03-17 |
20110065081 | Electrically erasable writable educational flash card - The invention provides an electrically erasable writable educational flash card comprising electronic display that displays prescribed patterns such as text characters of a language, Arabic numbers, and graphics pictures of a learning subject. Two or more of such cards comprise a youth oriented subject learning educational flash card set. Such card has a look of conventional paper flash card but with advantages: user can erase and write the displaying contents—making the learning activities more enjoyable and effective; the card is ergonomically fitful for young children to play with; and the card does not consume conventional paper, which is made from plant, trees in particular, and therefore conserves forest and environment. The invention further provides an electronic card writer for user to electrically erase and write the contents on the card's display. Alternatively, a commercially available computer or an electronic paper printer can be adapted as an electronic card writer. | 2011-03-17 |
20110065082 | Device,system, and method of educational content generation - Device, system, and method of educational content generation. For example, a method of generating digital educational content comprises: (a) creating a digital learning object by: receiving user selection of a template from a repository of templates of digital learning objects, the template representing a composition of one or more digital educational content elements within a screen; receiving user selection of a layout from a repository of layouts of digital learning objects, the layout representing an on-screen arrangement of said one or more educational content elements within said screen; receiving user input of data for said template; receiving user input of parameters for said template; inserting the user input of data into said template; inserting the user input of parameters into said template; receiving user input of meta-data for said template; (b) applying said layout to said template containing therein (i) said user input of data and (ii) said user input of parameters and (iii) said user input of meta-data; (c) storing said digital learning object in a repository of digital learning objects. | 2011-03-17 |
20110065083 | Compositions and Methods for Enhancing the Viability of Animal Cells, Tissues, and Organ Explants - Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity. | 2011-03-17 |
20110065084 | INTEGRATED OXYGEN MEASUREMENT AND CONTROL FOR STATIC CULTURE VESSELS - A system and method for measuring and controlling oxygen in a culture vessel utilizes a non-invasive oxygen sensor and an agitator. A controller controls the agitator based on feedback supplied by the oxygen sensor. The agitator is used to increase oxygen transport into the liquid phase thereby raising the level of oxygen in the culture medium. The agitator driven equilibration results in precise control of the culture medium oxygen. | 2011-03-17 |
20110065085 | NOVEL HEPARIN ENTITIES AND METHODS OF USE - The present invention relates to immobilized biologically active entities that retain a significant biological activity following manipulation. The invention also comprises a medical substrate comprising a heparin entity bound onto a substrate via at least one heparin molecule, wherein said bound heparin entity is heparinase-1 sensitive. | 2011-03-17 |
20110065086 | Methods of producing homogeneous plastic-adherent aptamer-magnetic bead-fluorophore and other sandwich assays - Methods are described for assembly of DNA aptamer-magnetic bead (“MB”) conjugate plus aptamer-quantum dot (“QD”) aptamer-fluorescent nanoparticle or other aptamer-fluorophore, aptamer-chemiluminescent reporter, aptamer-radioisotope or other aptamer-reporter conjugate sandwich assays that enable adherence to glass, polystyrene and other plastics. Adherence to glass or plastics enables detection of surface-concentrated partitioning of fluorescence versus background (bulk solution) fluorescence in one step (without a wash step) even when the external magnetic field for concentrating the assay is removed. This assay format enables rapid, one-step (homogeneous) assays for a variety of analytes without wash steps that do not sacrifice sensitivity. | 2011-03-17 |
20110065087 | NOVEL HIV TARGETS - A set of cellular genes that were identified by siRNA screening as being essential for Human Immunodeficiency Virus (HIV) infection. These genes are host cellular factors involved in DNA repair, specifically in the base excision repair pathway. | 2011-03-17 |
20110065088 | METHOD AND DEVICES FOR RAPID DIAGNOSIS OF FOOT-AND-MOUTH DISEASE - A rapid immunoassay method and apparatus for detecting foot and mouth disease virus are disclosed. The method and test device permit pen-side testing of animals and provide test results within a relatively short time period. In a preferred embodiment, the method and apparatus provide a means for differentiating between FMDV-infected and FMDV-vaccinated animals. | 2011-03-17 |
20110065089 | NOVEL STRAIN OF SARS-ASSOCIATED CORONAVIRUS AND APPLICATIONS THEREOF - The invention relates to a novel strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from a sample collected in Hanoi (Vietnam), reference number 031589, nucleic acid molecules originating from the genome of same, proteins and peptides coded by said nucleic acid molecules and, more specifically, protein N and the applications thereof, for example, as diagnostic reagents and/or as a vaccine. | 2011-03-17 |
20110065090 | Asymmetrically branched polymer conjugates and microarray assays - A method of detection comprising a conjugate of a randomly and asymmetrically branched dendritic polymer. | 2011-03-17 |
20110065091 | Coronavirus, Nucleic Acid, Protein, and Methods for the Generation of Vaccine, Medicaments and Diagnostics - A new coronavirus is disclosed herein with a tropism that includes humans. Means and methods are provided for diagnosing subjects (previously) infected with the virus. Also provided are among others vaccines, medicaments, nucleic acids and specific binding members. | 2011-03-17 |
20110065092 | USE OF NONVIABLE PARTICLES COMPRISING AN INTERNAL CONTROL (IC) NUCLEIC ACID - The present invention relates to the use of non-viable particles (and in particular liposome particles, particles which are in the form of a viral protein coat, non-viable genetically modified organisms or particles made of synthetic polymers), comprising an internal control (IC) nucleic acid sequence as an internal control in nucleic acid-based analysis. The present invention further relates to non-viable particles comprising an IC nucleic acid and kits for carrying out the methods and uses of the invention. | 2011-03-17 |
20110065093 | NOVEL TOOL FOR THE ANALYSIS OF NEURAL CIRCUITS - The application relates to an isolated transsynaptic virus expressing an exogenous fluorescent activity sensor. Preferably, the transsynaptic virus is a rhabdovirus, e.g. rabies virus, or a herpesvirus, preferably an alphaherpesvirus, e.g. pseudorabies virus. The fluorescent exogenous activity sensor used in the transsynaptic virus can be a fluorescent protein Ca | 2011-03-17 |
20110065094 | METHOD AND KIT FOR DETECTION/IDENTIFICATION OF VIRUS-INFECTED CELL - Disclosed is a means for specifically detecting and identifying a virus-infected cell in a floating cell system by a simple manipulation and with high sensitivity. A virus-infected cell can be detected and identified by the following steps (1) to (5): (1) adding a first labeled antibody which has been labeled with a first labeling substance and is directed against a cell surface antigen specific to a target cell to a sample and allowing the mixture to react; (2) immobilizing a protein in the presence of an RNAstabilizing agent; (3) treating the protein with a surfactant; (4) adding a labeled nucleic acid probe for a nucleic acid specific to a target virus to cause the hybridization; and (5) detecting a cell labeled with both the first labeled antibody and the labeled nucleic acid probe by flow cytometry. | 2011-03-17 |
20110065095 | ANTI-(INFLUENZA A VIRUS SUBTYPE H5 HEMAGGLUTININ) MONOCLONAL ANTIBODY - A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody which can be used for the immunoassay are disclosed. The antibody or an antigen-binding fragment thereof of the present invention undergoes antigen-antibody reaction with hemagglutinin of H5 subtype influenza A virus, and the corresponding epitope of the antibody or an antigen-binding fragment thereof is located in a region other than the receptor subdomain (excluding C-terminal region thereof consisting of 11 amino acids), which antibody or an antigen-binding fragment thereof does not have neutralizing activity against the influenza A virus. | 2011-03-17 |
20110065096 | VIRAL DIAGNOSTIC METHOD AND WELL FOR USE IN SAME - The present invention relates to a single flat-based well suitable for use in a viral diagnostic method. More particularly, the well has a planar or flat base, as opposed to a curved base. The invention also relates to a viral diagnostic method that employs such single wells. In an embodiment of this method a specially developed tissue culture medium supplemented with hormones and enzymes is employed. | 2011-03-17 |
20110065097 | Apparatus and Method of Contaminant Detection for Food Industry - The present invention is a method and apparatus for contaminant detection in the food industry. Particularly, the method and apparatus involve collecting air samples containing aerosolized contaminate particles from a foodstuff and analyzing the sample for presence of a contaminate. Aerosol lab-on-a-chip and/or electronic nose devices are utilized for the detection of contaminant particles. | 2011-03-17 |
20110065098 | METHODS AND REAGENT KITS FOR IMPROVING ACCURACY OF SAMPLE CLASSIFICATION - The present invention relates to methods for increasing the accuracy of sample classification characterized by the detection of the protein YKL-40 and the protein MASP2 in the samples and methods for determining the efficacy of a drug in treating a cancer in an individual, as well as reagent kits for the same uses. | 2011-03-17 |
20110065099 | METHOD OF PRETREATING SPECIMEN AND IMMUNOASSAY USING THE SAME - The present invention provides a method of pretreating a specimen, which allows measurement according to an immunoassay to be carried out on a specimen from nasal secretion while preventing non-specific reactions. According to this method, the specimen from nasal secretion is treated with a protease beforehand and then an immunoassay is performed. As the protease, it is preferable to use semi-alkaline protease (EC 3.4.21.63). Furthermore, it is preferable that a substance to be pretreated by the pretreatment method according to the present invention is an influenza virus contained in the specimen from nasal secretion. The immunoassay preferably is an immunoagglutination assay. Examples of the immunoagglutination assay include a turbidimetric immunoassay, a latex turbidimetric immunoassay, and a latex agglutination assay that is performed on a slide glass. | 2011-03-17 |
20110065100 | Transcription biomarkers of biological responses and methods - This invention provides transcription regulatory control sequences, the activity of which function as biomarkers for a variety of biological responses. This invention also provides expression constructs in which a biomarker transcription regulatory sequence is operably linked with a sequence for a reporter. Cells that comprise these expression constructs can be used in assays to identify conditions that modulate activity of the biological response. | 2011-03-17 |
20110065101 | Multiple-sample microfluidic chip for DNA analysis - Aspects of the disclosure provide a microfluidic chip. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain for electrophoretic separation. The first domain includes at least a first reaction reservoir designated for PCR amplification based on a first sample, and a second reaction reservoir designated for PCR amplification based on a second sample. The second domain includes at least a first separation unit coupled to the first reaction reservoir to received first amplified DNA fragments based on the first sample, and a second separation unit coupled to the second reaction reservoir to received second amplified DNA fragments based on the second sample. The first separation unit is configured to perform electrophoretic separation for the first amplified DNA fragments, and the second separation unit is configured to perform electrophoretic separation for the second amplified DNA fragments. | 2011-03-17 |
20110065102 | OSTEOARTHRITIS-SENSITIVE GENE - It is an object of the present invention to provide a method and kit for diagnosing osteoarthritis which involves genetic diagnosis or hemodiagnosis. The present invention provides a method for diagnosing a genetic susceptibility of a subject to osteoarthritis, which comprises detecting at least one polymorphism selected from polymorphisms existing in a gene (Dual Intracellular on Willebrand factor A gene; DIVA gene), encoding the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence substantially homologous thereto, in a DNA-containing sample collected from the subject, wherein an allele frequency of one of alleles is higher in arbitrary osteoarthritis group than in arbitrary non-osteoarthritis group. | 2011-03-17 |
20110065103 | USE OF RNA FOR REPROGRAMMING SOMATIC CELLS - The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically, the present invention provides methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in particular pluripotency, by introducing RNA encoding factors inducing the de-differentiation of somatic cells into the somatic cells and culturing the somatic cells allowing the cells to de-differentiate. | 2011-03-17 |
20110065104 | REAL-TIME ASSAYS OF NEURO-HUMORAL FACTORS TO ASSESS CARDIOVASCULAR STRESS - The present invention relates to rapid assays for neuro-humoral factors modulated in response to cardiovascular stress and integration of data obtained from such assays to provide profiles of response to cardiovascular stress that can guide therapy. | 2011-03-17 |
20110065105 | Novel transcription factor-based biosensor - The present invention provides for a system comprising a BmoR transcription factor, a σ | 2011-03-17 |
20110065106 | Recombinase polymerase amplification - This disclosure describe three related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of the bacterial RecA and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods has the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods allow amplification of DNA up to hundreds of megabases in length. | 2011-03-17 |
20110065107 | Detection of gleevec resistance - The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin- | 2011-03-17 |
20110065108 | Urine Transport Medium - A method of stabilizing a patient sample such as a urine sample to prevent degradation of nucleic acids for subsequent analysis for pathogen detection involves adding a stabilizing solution to an aliquot of the sample. A stabilizing solution comprising a chaotrope, a non-ionic detergent, and a buffer preserves urine samples for at least 28 days at room temperature for storage and transportation to an analytical facility for screening for pathogen nucleic acids. | 2011-03-17 |
20110065109 | RNA INTERFERENCE MEDIATING SMALL RNA MOLECULES - Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a | 2011-03-17 |
20110065110 | Method For The Extraction And Purification Of Nucleic Acids On A Membrane - The invention relates to a method for the extraction and detection of nucleic acids on a membrane, making it possible to identify the microorganisms present in low concentration in a liquid or gaseous medium, as well as a novel lysis composition comprising guanidium chloride and between 0.1 and 1% N-Lauroyl-Sarcosine (NLS) making it possible to implement this method. | 2011-03-17 |
20110065111 | Compositions For Use In Genotyping Of Klebsiella Pneumoniae - The present invention relates generally to identification and characterization of genotypes of | 2011-03-17 |
20110065112 | METHOD FOR IDENTIFYING LINEAGE-RELATED ANTIBODIES - In certain embodiments, the method may comprise: a) obtaining the antibody sequences from a population of B cells; b) grouping the antibody sequences to provide a plurality of groups of lineage-related antibodies; c) testing a single antibody from each of the groups in a bioassay and, after the first antibody has been identified, d) testing further antibodies that are in the same group as the first antibody in a second bioassay. In another embodiment, the method may comprise: a) testing a plurality of antibodies obtained from a first portion of an antibody producing organ of an animal; b) obtaining the sequence of a first identified antibody; c) obtaining from a second portion of said antibody producing organ the sequences of further antibodies that are related by lineage to said first antibody; and, c) testing the further antibodies in a second bioassay. | 2011-03-17 |
20110065113 | RECURRENT GENE FUSIONS IN PROSTATE CANCER - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for prostate cancer. | 2011-03-17 |
20110065114 | STEROIDOGENESIS MODIFIED CELLS AND METHODS FOR SCREENING FOR ENDOCRINE DISRUPTING CHEMICALS - An isolated steroidogenesis modified cell comprising one or more steroid biosynthesis knock down nucleic acid operatively linked to a promoter, wherein the steroid biosynthesis knock down nucleic acid reduces the expression of a gene selected from the group CYP21A2, CYP11A1, CYP17A1, CYP19A1, 3-βHSD1, 3-βHSD2, 17-βHSD1, StAR, HMGR, CYP11B2, CYP11B1, 5α-Reductase 2, SULT1E1, CYP3A4 and UTG1A1, wherein the cell comprises reduced expression of one or more of said genes. The cells are useful for identifying endocrine disruptors. Accordingly, the disclosure includes in a further aspect a screening assay for identifying an endocrine disruptor comprising:
| 2011-03-17 |
20110065115 | METHODS FOR IDENTIFYING AN INCREASED LIKELIHOOD OF RECURRENCE OF BREAST CANCER - Methods of identifying a mammal having an increased likelihood of recurrence of breast cancer includes identifying in a breast tissue sample of the mammal expression of at least two genes selected from the group consisting of Hs.125867 (EVL), Hs.591847 (NAT1), Hs.208124 (ESR1), Hs.26225 (GABRP), Hs.408614 (ST8SIA1), Hs.480819 (TBC1D9), Hs.504115 (TRIM29), Hs.523468 (SCUBE2), Hs.532082 (IL6ST), Hs.592121 (RABEP1), Hs.79136 (SLC39A6), Hs.82128 (TPBG), Hs.95243 (TCEAL1), Hs.95612 (DSC2), Hs.654961 (FUT8), Hs.1594 (CENPA), Hs.184339 (MELK), Hs.26010 (PFKP), Hs.592049 (PLK1), Hs.370834 (ATAD2), Hs.437638 (XBP1), Hs.444118 (MCM6), Hs.469649 (BUB1), Hs.470477 (PTP4A2), Hs.473583 (YBX1), Hs.480938 (LRBA), Hs.524134 (GATA3), Hs.531668 (CX3CL1), Hs.532824 (MAPRE2), Hs.591314 (GMPS), Hs.83758 (CKS2) and Hs.99962 (SLC43A3) and subsets of the genes. | 2011-03-17 |
20110065116 | Method for Detecting ATP - Methods are provided for detection of concentrations of less than 3.4 picomolar of adenosine triphosphate (ATP) using recombinant luciferase in the luciferin-luciferase reaction. Aspects include a low pH composition for use in detecting the presence of ATP. The low pH composition can include low concentrations of detergents and can be used in combination with methods for reading, calculating and interpreting luminescence generated by the ATP-luciferin-luciferase reaction. | 2011-03-17 |
20110065117 | Mesothelioma Specific Transferred Promoter And Use Thereof - Provided is a promoter showing transcriptional activity in a mesothelioma-specific manner and showing low transcriptional activity in other kinds of cancer cells and normal cells including mesothelium. Also provided are applications of the promoter, and more specifically, a gene therapy vector and a therapeutic agent for mesothelioma each including the promoter. The promoter includes a CRI1 gene-derived promoter, which is one kind of mesothelioma markers. The use of a vector including a cell death-inducing gene or a cell lysis-inducing gene as a transgene and carrying the CRI1 gene-derived promoter upstream of the transgene can induce a cell death or cell lysis action in a mesothelioma-specific manner. That is, the gene therapy vector and the therapeutic agent for mesothelioma each include a virus vector carrying the CRI1 gene-derived promoter. | 2011-03-17 |
20110065118 | Drug Screening Using Islet Cells and Islet Cell Progenitors from Human Embryonic Stem Cells - This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High quality populations of islet cells can be produced in commercial quantities for use in research, drug screening, or regenerative medicine. | 2011-03-17 |
20110065119 | REVERSE PROGENY MAPPING - Provided is a method for mapping traits in organisms, in particular in plants. The method comprises a) providing a population of SDR-0 organisms, in particular plants, that each arise from one member of a population of unreduced cells resulting from second division restitution, in particular a population of unreduced spores; b) producing SDR-1 progeny populations of each of these SDR-0 organisms; c) phenotyping the SDR-1 progeny populations to identify segregating traits within each SDR-1 progeny population; d) if segregating progeny are present in a SDR-1 progeny population, genotyping the corresponding SDR-0 organism and comparing the genotype thereof with the genotype of the other SDR-0 organisms to identify heterozygous chromosomal regions associated with the occurrence of the segregating trait identified in the SDR-1 progeny population. | 2011-03-17 |
20110065120 | Method and a Reagent kit to Improve the Accuracy of Sample Classification - A method for increasing the veracity of classification by detecting protein YKL-40 and MASP2 levels in the samples, comprises detecting the content of the YKL-40 and MASP2 in the samples; the ratio of the content of YKL-40 to the that of MASP2 acted as variable, receiving the ROC curve according to the sensitivity and specialty of the difference threshold value to the diagnosis for the cancer, calculating an area under the curve AUC; classifying the samples according to the value of the AUC, sensitivity and specialty. And a kit for detecting the protein YKL-40 and MASP2 levels in the samples. | 2011-03-17 |
20110065121 | METHOD FOR THE DETECTION OF APOPTOSIS - Methods for the detection of apoptosis by measuring apoptotic bodies shed by apoptotic cells are provided, as are kits to carry out such methods. | 2011-03-17 |
20110065122 | METHOD FOR ACCESSING MICROBIAL DIVERSITY - A method of interfering with quorum sensing regulation of genes to promote cell growth is disclosed. The method of is aimed at accessing microbial biodiversity. The method involves obtaining an environmental sample comprising at least one novel (uncultivated in the laboratory) microorganism, contacting the environmental sample with an effective amount of an agent or combination of agents which interferes with the quorum sensing regulation of genes, growing the treated sample in a culture medium containing the quorum sensing signal disrupting agent or agents, and analyzing the colonies of microorganisms grown to demonstrate genetic novelty. | 2011-03-17 |
20110065123 | Methods for diagnosis of Clostridium difficile and methods and vectors for recombinant toxin expression - Cell-based methods for rapid real time assay of a presence of | 2011-03-17 |
20110065124 | Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses - The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. | 2011-03-17 |
20110065125 | CONTROLLED PLATELET ACTIVATION TO MONITOR THERAPY OF ADP ANTAGONISTS - A method is provided of determining whether an individual has reduced ability to form platelet thrombi due to inhibition of platelet activation initiation, signal transduction and/or GPIIb/IIIa blockade. A blood sample is obtained from the individual being assessed. The blood sample is mixed in combination with 1) an anticoagulant; 2) sufficient buffer to maintain the pH and salt concentration of the anticoagulated blood within a range suitable for platelet aggregation; 3) a platelet GPIIb/IIIa receptor ligand immobilized on a solid surface; 4) one or more agents to enhance a signal transduction pathway and 5) a receptor activator. The combination is incubated under conditions for agglutinating particles. Platelet-mediated agglutination is assessed in the agitated mixture. The absence of agglutination indicates that the individual has a reduced ability to form platelet thrombi. | 2011-03-17 |
20110065126 | SUBSTANCE-IMMOBILIZING SUBSTRATE, SUBSTANCE-IMMOBILIZED SUBTRATE, AND ANALYSIS METHOD - The present invention relates to a substance-immobilizing substrate for immobilizing a substance to be detected by chemiluminescence. The substance-immobilizing substrate of the present invention comprises a metal portion composed of at least one metal selected from the group consisting of chromium and molybdenum, or an alloy of the metal on at least a portion of a surface of the substrate. The present invention further relates to a substance-immobilized substrate wherein a substance is immobilized on the substance-immobilizing substrate. The substance is immobilized on the metal portion and the substrate is used for detecting the immobilized substance by chemiluminescence. The present invention further relates to an analysis method comprising directly or indirectly detecting by chemiluminescence a substance that is immobilized on a substrate. The substrate comprises a metal portion composed of at least one metal selected from the group consisting of chromium and molybdenum, or an alloy of the metal on at least a portion of a surface of the substrate, and the substance is immobilized on the metal portion. | 2011-03-17 |
20110065127 | Detection of Degradative Enzymes and Biomolecules in Bodily Fluids - Provided herein are methods, kits and compositions useful in detecting degradative enzymes and biomolecules in bodily fluid samples. | 2011-03-17 |
20110065128 | Methods for Assessing CDK5 Activation and Function - As described herein, signaling events occurring in neurons or at neuronal synapses have been identified that involve Cdk5 and various other molecules which bind to, are activated by, and/or activate Cdk5. Of particular relevance are interactions that stimulate calpain cleavage of p35 into p25, which binds Cdk5 in pathologic states. Assays to identify modulators of these interactions are provided. | 2011-03-17 |
20110065129 | INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION - This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation. | 2011-03-17 |
20110065130 | Diagnosing and Grading Gliomas Using a Proteomics - The present invention provides for a proteomic approach to grading gliomas, and for predicting patient survival. In addition to employing global protein expression patterns, such as by mass spectrometry, particular target proteins whose expression is altered in various gliomas can be used to predict the stage/classification of a glioma, as well as to indicate whether a given patient will be a short- or long-term survivor. | 2011-03-17 |
20110065131 | ASSAYS FOR MUTAGENESIS DETECTION - The disclosure provides methods, systems, and kits for assaying an agent for mutagenic properties. The methods systems and kits utilize a DEL selectable marker and a colorimetric detection systems. Also included are methods systems and kits that utilize a DEL selectable marker and a regent that detects mitochondrial activity. | 2011-03-17 |
20110065132 | Identification of Actinobacillus actinomycetemcomitans Antigens for use in the Diagnosis, Treatment and Monitoring of Periodontal Diseases - Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by | 2011-03-17 |
20110065133 | O-ring Systems and Methods for Quantification of Multiplex Biomarkers in Multiple Samples - Kits and methods of using O-rings having apertures are provided herein. O-rings are useful for incubating with a sample fluid potentially having one or more biomarkers, in order to detect the presence of the biomarkers. O-rings can be readily organized in a trackable manner prior to and during incubation with the sample fluid. O-rings can also be readily transferred and organized into one or more trackable arrays for detecting the presence of bound biomarkers and measuring the signaling product generated by bound detect molecule-linked enzymes present in a homogeneous solution with a spectrophotometer. | 2011-03-17 |
20110065134 | SYNTHETIC PEPTIDES IMMUNO-REACTIVE WITH RHEUMATOID ARTHRITIS AUTO-ANTIBODIES - Embodiments of the present invention relate to a three dimensional matrix of selected, synthetic peptide mimic sequences that are preferentially recognized by auto-antibodies, specifically by autoimmune antibodies, to be detected in patients afflicted with rheumatic arthritis, enabling enhanced sensitivity and specificity in detection of these antibodies in pre-symptomatic patients, in patients showing symptoms as well as patients confirmed positive for rheumatoid arthritis. | 2011-03-17 |
20110065135 | LIPOSOME COMPOSITION, ITS PRODUCTION PROCESS, AND METHOD FOR ANALYZING ANALYTE USING THE SAME - A liposome composition capable of including a chemical substance such as an electrochemiluminescent substance in an internal aqueous phase of the liposome at a higher concentration, and a production method thereof, as well as an analytical method of an analyte that enables an analyte to be analyzed with a high sensitivity using the liposome composition are provided. In a liposome composition containing a liposome, and a chemical substance enclosed in an internal aqueous phase of the liposome, a lipid bilayer composing the liposome has a positive or negative charge, and the chemical substance has a charge opposite to the charge of the lipid bilayer. | 2011-03-17 |
20110065136 | Methods and Devices for Detecting Glomerulonephritis and Associated Disorders - Methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described. | 2011-03-17 |
20110065137 | Methods and Devices for Detecting Obstructive Uropathy and Associated Disorders - Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described. | 2011-03-17 |
20110065138 | Quantitative Method For Detecting Yessotoxins In Fishery Products On Based On The Activation That The Toxin Produces In Cellular Phosphodiesterases And Therapeutic Use Of This Activation - The present invention relates to a quantitative method for detecting yessotoxins in fishery products based on the activation the toxin produces on cellular phosphodiesterases and the therapeutic use of this activation. The cellular target of yessotoxin (YTX) and its analogs is the activation of phosphodiesterases (PDEs). The PDEs-YTX bond produces a measurable signal. The bond can be quantified by means of an affinity biosensor or by fluorescence. The biosensor detects biomolecular interactions and allows determining the presence of YTX due to its interaction with PDEs. The variations in the degradation rate of the fluorescent derivative anthraniloyl-cAMP are determined by means of plate fluorescence. The rate at which the PDEs degrade this molecule increases in the presence of YTX. YTX inhibits immunological activation of mastocytes in rats and induces a cytotoxic effect in human hepatocarcinoma cells, which implies two therapeutic uses of YTXs as an antiallergic and antitumor compound. | 2011-03-17 |
20110065139 | DIAGNOSTIC DEVICE FOR IDENTIFYING RUPTURE OF MEMBRANE DURING PREGNANCY - A diagnostic device is provided for distinguishing between amniotic fluid and urine in female secretion. The device can be employed as a panty shield or can be adhered onto a panty shield or can be employed in a simple pad that is pressed against a substrate provided with female secretion. | 2011-03-17 |
20110065140 | PROGRAMMABLE ELECTROMAGNETIC ARRAY FOR MOLECULE TRANSPORT - An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more coils individually, to reverse the current for one or more coils individually, and to generate a specific magnetic flux distribution and gradient across two or more coils; wherein the metal core head is at one end of the coil and the metal core head has a geometry to create a desired magnetic flux, intensity and gradient, in a region of interest between two adjacent coils; further wherein the device is functionally coupled to a fluidic device to concentrate and transport magnetic particles in a fluid without fluidic movement of the fluid. | 2011-03-17 |
20110065141 | Method of Diagnosing Pancreatic Cancer with the Use of N-Binding Type Sugar Chains - The present invention is to provide a novel marker for diagnosing pancreatic cancer, a method for determining if a subject has pancreatic cancer utilizing the marker, etc. The present inventors collected blood from patients of 78 cases in total including patients of 24 cases with pancreaticobiliary-duct benign disorder (16 gallstone cases and 8 pancreatitis cases) and patients of 54 cases with pancreatic cancer, and mass spectrometry was performed on N-linked sugar chains in plasma. From the 74 mass-spectrometric peaks detected, 65 sugar chains were extracted based on the results of PAM analysis. These extracted sugar chains were then used to predict pancreatic cancer or pancreaticobiliary-duct benign disorder, to correctly diagnose 74% cases. Further, a T-test was performed between the two groups, the group of pancreaticobiliary-duct benign disorder and the group of pancreatic cancer, which identified two sugar chains, the sugar chain of m/z 3031 and the sugar chain of m/z 2362, as sugar chains demonstrating significant difference (p<0.05) and exhibiting 2-fold or greater difference in expression levels between the two groups. The rate of correct detection when using these sugar chains was calculated with six classifiers, all of which gave the result of about 70% correct detection. | 2011-03-17 |
20110065142 | SEBOCYTES, SEBOCYTE-CELL LINE AND USES THEREOF - Adipose cells (sebocytes) are described, The invention especially relates to sebaceous gland cells and to a sebaceous gland cell line with the property of being continuously grown over many sub-cultures. The sebocytes are excellently suited for useful applications. | 2011-03-17 |
20110065143 | Multiphoton Scanning Flow Cytometer for Multicellular Aggregates - A flow cytometry system suitable for characterizing multicellular aggregates during culture and before implantation combines a low shear flow channel with a multiphoton laser scanning microscope, the latter permitting the characterization of interior and exterior cells in optical isolation from other cells for a representative sampling of fluorescent activity. Imaging capabilities permit sophisticated statistical measurements reflecting individual cell characteristics. | 2011-03-17 |
20110065144 | METHOD OF MEASURING EFFECTS OF COMPONENTS ON CELL REACTIVE OXYGEN SPECIES PRODUCTION - A method of determining the effects of a test component on intracellular ROS levels. The method can be used in marketing or in screening for useful components in reducing ROS levels in cells adversely affected by increased ROS generation. | 2011-03-17 |
20110065145 | WATER MAMAGEMENT - A method for detecting and enumerating viable microorganisms in a sample suspected of containing said microorganisms (1) contacting said microorganisms of said sample with at least one repair compound and a growth medium, and (2) incubating the product of steps (1), and (3) detecting and quantifying said viable microorganisms, in which the microorganisms are of the species | 2011-03-17 |
20110065146 | Expression of HIV polypeptides and production of virus-like particles - The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered. | 2011-03-17 |
20110065147 | Methods and reagents for modulating cholesterol levels - The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human). | 2011-03-17 |
20110065148 | PEPTIDES AND USES THEREOF - The present invention relates to monovalent fucose-binding peptides. The peptides may be recombinantly produced or chemically synthesized. Preferably the peptides are derived from a lectin, in particular | 2011-03-17 |
20110065149 | METHOD OF PRODUCING FUSED PROTEIN - Described herein is a polynucleotide encoding a fusion protein comprising two or more polypeptide domains and a polypeptide linker joining the domains, wherein the sequence of the polynucleotide encoding the polypeptide linker is selected such that when the mRNA transcribed from the polynucleotide is translated in a host cell transfected with the polynucleotide, the translation rate of the mRNA region encoding the polypeptide linker is slower than the translation rate of the mRNA region encoding the polypeptide domain immediately upstream thereof. Also provided are a vector transfected with the polynucleotide of the present invention so that the polynucleotide can be expressed in the host cell; a host cell transformed by that vector; and a process for producing a fusion protein comprising culturing the host cell, and recovering the fusion protein thus produced. | 2011-03-17 |
20110065150 | REACTION VESSEL COMPRISING ELECTRICALLY CONDUCTING POLYMER AS A HEATING ELEMENT - A reaction vessel for conducting a chemical or biochemical reaction, such as a polymerase chain reaction wherein electrically conducting polymer is arranged to act as a heating element. The profile of the electrically conductive polymer differs in different regions of the vessel so as to control thermal gradients. The profile of the electrically conductive polymer may be arranged to either increase or reduce the thermal gradient. Reaction systems comprising combinations of vessels of the invention and apparatus for heating them, as well as particular reactions vessels are also described and claimed. | 2011-03-17 |
20110065151 | NUCLEIC ACID AMPLIFICATION WITH SINGLE STRAND DNA BINDING PROTEIN - A method is disclosed in which circular DNA molecules are amplified preferentially in a mixture of circular DNA molecules and linear DNA molecules by the inclusion of single strand DNA binding protein. | 2011-03-17 |
20110065152 | PROCESS FOR PRODUCTION OF GALACTOOLIGOSACCHARIDES (GOS) - The present invention deals with an improved process for the production of high yield of pure Galactooligosaccharides using microbial whole cells in a reactor with cross flow hollow fiber microfiltration system. The process is economical as cell biomass is used repeatedly and eliminated the need to carry out downstream processing for the removal of mono and disacchacrides from the final product. | 2011-03-17 |
20110065153 | METHOD OF PRODUCING L-LYSINE - The ability and speed with which a coryneform bacterium can produce L-lysine are improved when the coryneform bacterium contains an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized. This is accomplished by successively enhancing the DNA coding for dihydrodipicolinate reductase, the DNA coding for dihydrodipicolinate synthase, the DNA coding for diaminopimelate decarboxylase, and the DNA coding for diaminopimelate dehydrogenase. | 2011-03-17 |
20110065154 | Deracemisation of Amines - The present invention relates to a method for the deracemisation or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. The invention also provides a method for selecting a suitable enzyme, particularly a suitable amine oxidase, and for the generation of novel enzymes suitable for use in the deracemisation method. | 2011-03-17 |
20110065155 | Productions of Organic Acid Salts from Digested Biomass and Their Uses and Self Cleaning Emitter Therefor - A method and means of producing organic acids (such as acetic acid) and calcium-, magnesium-, iron-organic acid salts (mostly acetates) from readily available, digested biomass (or biomass rich trash or waste) and limestone, or magnesium rich stone, or iron oxides is described. The invention also relates to the use of inexpensive, common chemicals in a process for treating water and for the separation of microbes from fresh water or saltwater. The treatments include denitrification, flocculation-separation of microbes and suspended particles, and removing dissolved phosphates (i.e., those rendered insoluble by the process) from water. Other benefits of induced bio-flocculation include separating microbes for use as animal feed or separating fatty algae harvested in the production of bio-diesel. A two way emitter for use with the process is also described. | 2011-03-17 |
20110065156 | PROCESS OF PRODUCTION OF VANILLIN WITH IMMOBILIZED MICROORGANISMS - A unique, innovative, and efficient system in order to convert ferulic acid into vanillin which involves the immobilization of actinomycetes in an effective solid support structure which is comprised of one or more pieces of a material, that is configured so as to allow effective aeration. | 2011-03-17 |
20110065157 | PHOTOBIOREACTOR FOR ALGAE GROWTH - The present invention provides a flow-through photobioreactor containing at least one thermoplastic multi-wall sheet having an upper layer and a lower layer having arranged there between at least two sidewalls, at least one inner wall and two or more end caps. Also provided is a process for the production of a biofuel with the inventive photobioreactor. The photobioreactor and process of the present invention have the following advantages: genetically engineered microbes that give higher yields cannot escape into the environment, water in the system does not evaporate, no weeding (presence of unwanted algae), UV light from the sun is filtered out by the reactor walls, temperature control is possible, CO | 2011-03-17 |
20110065158 | REGULATION OF PLANT METABOLISM - We describe a plant and plant cell which is modified to enhance the production of plant-derived oil in particular in non-seed tissue and including methods for the processing of plant derived biomass materials. | 2011-03-17 |
20110065159 | BIOMASS HYDROLYSIS - High-yielding method for chemical hydrolysis of lignocellulose into monosaccharides. The process of the invention can additionally be applied to cellulose, xylan and related biomass polysaccharides, such as galactan, mannan, or arabinan. The method is employed for hydrolysis of a biomass polysaccharide substrate. The process is carried out in an ionic liquid in which cellulose is soluble in the presence of catalytic acid at a temperature sufficiently high to initiate hydrolysis. Water is added to the reaction mixture after initiation of hydrolysis at a rate controlled to avoid precipitation yet avoid undesired sugar dehydration products such ad HMF. Hydrolysis product is useful as feedstock for fermentations including fermentation processes for ethanol, butanol and other fuels. | 2011-03-17 |
20110065160 | TREATMENT OF EUKARYOTIC CELLULAR BIOMASS - The application describes a process for treating a eukaryotic cell-derived biomass-containing stream including: (i) passing the stream through a chamber; (ii) pressurizing_the stream; (iii) introducing a gas into the pressurized stream, the gas being soluble within the eukaryotic cell-derived biomass; and (iv) depressurizing the stream to cause the solubilised gas to expand and disrupt the eukaryotic cell-derived biomass. The biomass may be derived from plant or animal materials. | 2011-03-17 |
20110065161 | BIPOLAR SOLID STATE MARX GENERATOR - A high-voltage bipolar rectangular pulse generator using a high efficiency solid-state boosting front-end and an H-bridge output stage is described. The topology of the circuit generates rectangular pulses with fast rise time and allows easy step-up input voltage. In addition, the circuit is able to adjust positive or negative pulse width, dead-time between two pulses, and operating frequency. The intended application for such circuit is algae cell membrane rupture for oil extraction, although additional applications include biotechnology and plasma sciences medicine, and food industry. | 2011-03-17 |
20110065162 | IRE-1alpha INHIBITORS - Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies. | 2011-03-17 |
20110065163 | Small Enzyme-Containing Granules - The invention provides small enzyme-containing granules having an inorganic salt core and an enzyme-containing layer coated over the core, and methods for producing such granules. The majority of the enzyme granules are less than 300 μm in diameter. The granules are suitable for incorporation into compositions such as cleaning, textile processing, and animal feed compositions. | 2011-03-17 |
20110065164 | DOUBLE-LABELLING AGENTS BASED ON VINYL SULPHONE - The invention relates to labelling agents containing a compound with two labelled molecules and a vinyl sulphone group. The invention also relates to the compounds, the method for obtaining these and the uses thereof in the marking of biomolecules and, more specifically, proteins. | 2011-03-17 |
20110065165 | METHOD FOR CULTURING PLANKTONIC MICROALGAE - The present invention relates to a method for culturing planktonic microalgae, comprising: culturing planktonic microalgae with a culture substrate containing a visible light transmissive fiber with a hydrophilic surface, where a space diameter between the fibers is from 10 μm to 500 μm. | 2011-03-17 |
20110065166 | NOx Removal System for Biogas Engines at Anaerobic Digestion Facilities - Provided herein are methods, devices and systems comprising a reactor that is operatively connected to: (a) a biogas production unit for converting waste to a biogas stream; and (b) an engine that utilizes the biogas stream from the biogas producing unit to produce energy and an engine exhaust. | 2011-03-17 |
20110065167 | Degradation of Hydrophobic Ester Pesticides and Toxins - The present invention relates to methods for degrading hydrophobic ester pesticides and toxins. In particular, the present invention relates to the use of insect esterases, and mutants thereof, in the bioremediation of hydrophobic ester pesticides and toxins residues, such as pyrethroid residues, contaminating the environment and horticultural commodities. | 2011-03-17 |
20110065168 | Preparation of Pregabalin and Related Compounds - Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed. | 2011-03-17 |
20110065169 | APPARATUS FOR HOUSING AN ORGAN DURING EVALUATION AND PRESERVATION - A vessel for housing an organ such as lungs from a mammal ex-vivo, for evaluation or preservation. A liquid solution suitable for evaluation or preservation of the lungs surrounds the organ, at least partly. The solution is circulated via an outlet and an inlet. Two pressure chambers are arranged between the walls of the vessel and the organ. A gas is introducible to the pressure chamber in order to expand the pressure chamber for occupying the spaces surrounding the organ. Then, the pressure inside the pressure chambers is increased in order to push the solution to a higher level so that the organ is immersed in the solution without necessitating addition of further solution. Alternatively, the vessel is exposed to an under pressure and the pressure chambers are open to the atmosphere. In a further alternative embodiment, a solution collection space has variable volume. | 2011-03-17 |
20110065170 | DEVICE FOR THE PRESERVATION OF A HEPATIC GRAFT IN NORMOTHERMIA - The invention relates to a device for the preservation of a hepatic graft in normothermia comprising a receptacle in which said hepatic graft is housed in a preservation solution, an arterial perfusion circuit, a portal perfusion circuit, at least one flow sensor of a perfusion circuit, and at least one pressure sensor of a perfusion circuit. For the purpose of increasing the preservation of the hepatic graft, the preservation device additionally comprises an arterial oxygenator connected to the arterial perfusion circuit, a portal oxygenator connected to the portal perfusion circuit, at least one arterial perfusion pump, at least one portal perfusion pump, a temperature exchange module configured to maintain the temperature inside the receptacle in normothermia, and a pressure and flow control device. | 2011-03-17 |
20110065171 | METHODS AND DEVICES RELATED TO A REGULATED FLOW ELECTROPORATION CHAMBER - The electroporation chamber and its related devices combine the features of an electroporation chamber that acts as a manifold for regulation of sample flow with those of a flow electroporation device to form a regulated flow electroporation device. The invention further comprises a novel regulated flow electroporation chamber that enables conditions in which a sample is uniformly processed in individual fractions or volumes in a fully closed (sterile) system. | 2011-03-17 |
20110065172 | DIRECT MIXING AND INJECTION FOR HIGH THROUGHPUT FLUIDIC SYSTEMS - A system and method of mixing and injecting discrete sample mixtures into a flow cytometer or other sample analysis apparatus may generally comprise a sample injection guide coupling a liquid handling apparatus with a sample analysis apparatus and facilitating injection of discrete sample mixtures into a fluidic system of the apparatus. | 2011-03-17 |
20110065173 | Vector - A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor. | 2011-03-17 |
20110065174 | HEPATITIS C VIRUS CODON OPTIMIZED NON-STRUCTURAL NS3/4A FUSION GENE - Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nucleic acids and peptides, as well as methods of making and using the aforementioned compositions including, but not limited to, diagnostics and medicaments for the treatment and prevention of HCV infection. | 2011-03-17 |