10th week of 2012 patent applcation highlights part 40 |
Patent application number | Title | Published |
20120058840 | GOLF CLUB HEAD - A hollow golf club head includes a sole, a crown, a skirt, and a striking face. The golf club includes a junction interconnecting the sole, crown, and skirt to the striking face, the junction including at least one stiffening member. | 2012-03-08 |
20120058841 | Football tee with multiple ball supporting modes - A tee includes a ball receiving recess shaped like the outer surface of the tip of a football so that the bottom portion of that tip may be supported within the recess. The recess is discontinuous consisting of two laterally opposed recess portions with a rearwardly facing opening and forward ribs. The opening permits the kicker to see the entirety of the football down to the tip. Textured surfaces are provided that extend forward to a downwardly depending shoulder. The textured surfaces are devised so that a football can be supported horizontally on the textured surfaces for squib kicks. The facing terminations of the recess portions are sized and configured to allow a football to be leaned against the tee engaging those terminations to allow the ball to be supported with its tip on a ground surface for onside kicks. | 2012-03-08 |
20120058842 | MAGIC ARC - The purpose of the shooting aid is to provide the basketball player with a visual trajectory of the correct path from the free throw line to the basketball hoop. The unique Tubular Arc Guide design offers the basketball player one of the most effective methods to increase their ability to make a higher percentage of free throws. | 2012-03-08 |
20120058843 | HOCKEY STICK BLADE - A hockey stick blade assembly has forehand and backhand blade members with respective toe ends and heel ends, plus a bridging member interconnecting the two toe ends. The forehand member has a forehand contact face and a back face, and the backhand member has a backhand contact face and an inner face. The forehand member's heel end is attached or attachable to an elongate shaft. The backhand member's heel end lies closely adjacent to, and is preferably slidable relative to, the back face of the forehand member, creating a hollow zone bounded by the bridging member, the back face of the forehand member, and the inner face of the backhand member, and open at both its upper and lower ends. The blade assembly can be configured to provide any desired combination of forehand and backhand contact surface profiles. Flexing of the forehand member is accommodated by the slidability of the heel end of the backhand member relative to the forehand member. The blade assembly can be of unitary construction, or can constructed by mounting a backhand adapter to the backhand face of a convention hockey stick blade. | 2012-03-08 |
20120058844 | Composition of baseball's core - A baseball includes a core comprised of coconut fiber, rubber, and solvent; and a cover sewn on the core by stitches. The coconut fiber having a predetermined percentage by weight is crushed, the rubber having a predetermined percentage by weight is gelled, the coconut fiber and the rubber are mixed with the solvent having a predetermined percentage by weight, and the mix is subjected to molding, heating, and cooling to produce the core. | 2012-03-08 |
20120058845 | ELECTRONIC COMPONENT ENCLOSURE FOR AN INFLATED OBJECT - This document provides methods and materials for securely retaining electronic components within an inflatable object. For example, basketballs having a boot structure for securely retaining one or more electronic components (e.g., a sensor and/or a battery) within the basketball are provided. | 2012-03-08 |
20120058846 | PNEUMATIC INFLATION VALVE CORE FOR INFLATABLE SPORTS BALL - An inflatable sports ball and its pneumatic inflation valve core are provided. The pneumatic inflation valve core includes a passage penetrating the pneumatic inflation valve core in a lengthwise direction. The passage is provided for receiving an inflation needle which is served for inflating a ball bladder of an inflatable sports ball. When an inflation needle inserts into the passage of the pneumatic inflation valve core, since the pneumatic inflation valve core has adequate length, the pneumatic inflation valve core prevents the inflation needle from piercing through the ball bladder as the ball bladder is flat. | 2012-03-08 |
20120058847 | TENSIONER WITH EXPANDING SPRING FOR RADIAL FRICTIONAL ASYMMETRIC DAMPING - A tensioner is disclosed that may be part of a power system where the tensioner provides tension to an endless power transmitting element such as a belt, chain, or other continuous loop. The tensioner has an arm that is rotatable about a first axis and includes an arm arbor having a slot therethrough, a bushing having a protrusion and being positioned adjacent the arm arbor with the protrusion received in the arm arbor's slot, and a spring coupled to the arm urging the arm to rotate about the first axis into tensioning engagement with a power transmitting element. The spring is positioned where it can radially expand into contact with the protrusion of the bushing as the arm is rotated in a direction opposite the direction of tensioning engagement such that the bushing is urged radially outward relative to the arm arbor to provide frictional damping. | 2012-03-08 |
20120058848 | Tensioner With Expanding Spring For Radial Frictional Asymmetric Damping - A tensioner may be part of a power system to tension an endless power transmitting element. The tensioner includes an arm having an arm arbor with a slot therethrough that is rotatable about a first axis, a bushing having a sleeve that includes a cut-out and a removable sleeve-segment that has a protrusion thereon, the sleeve-segment being receivable in the cut-out with the protrusion in the slot, and a spring coupled to the arm for rotation of the arm about the first axis into tensioning engagement with a power transmitting element. The spring is positioned where it can radially expand into contact with the protrusion of the bushing, at least the protrusion on the sleeve-segment, as the arm is rotated in a direction opposite the direction of tensioning engagement such that the bushing is urged radially outward relative to the arm arbor to provide frictional damping. | 2012-03-08 |
20120058849 | FRICTION DRIVE BELT AND MANUFACTURING METHOD THEREOF - In a friction drive belt (B), a belt body ( | 2012-03-08 |
20120058850 | Auxiliary Drive Assembly For A Front Drive Assembly - A vehicle front drive assembly includes an auxiliary drive assembly for a vehicle which is driven by an engine which is cooled by a fan. The auxiliary drive assembly includes an input pulley for receiving torque from the engine, a fan drive pulley, a belt engaging the input pulley and the drive pulley and an auxiliary drive housing. The housing supports the belt and has a first opening adapted to receive a torque transmitting member which transmits torque from the engine to the input pulley. The housing has a second opening which receives a fan drive shaft which transmits torque from the fan drive pulley to the fan. | 2012-03-08 |
20120058851 | POWER TRANSMITTING TOOTHED BELT AND POWER TRANSMITTING DEVICE - A power transmitting toothed belt having improved positioning accuracy between the toothed belt and a pulley, increased durability, and reduced contact noise, comprising a rubber back layer, a plurality of core wires and a rubber layer having a plurality of belt teeth, wherein the belt teeth are at oblique angle with respect to the direction of the width of the belt. The belt teeth intersect with straight pulley teeth having a pitch equal to the pitch of the belt teeth. | 2012-03-08 |
20120058852 | TRANSMISSION FOR AN ELECTRIC OR HYBRID DRIVE - A transmission which is pre-eminently suitable for an electric and/or hybrid drive has an input which can be connected to an electromotor/generator, and an output which can be connected to a load. The transmission has two parallel transmission paths between the input and output, first coupling means being present in the first transmission path and second coupling means being present in the second transmission path. Furthermore, a gear reduction is present in at least either of the two transmission paths. The first coupling means are arranged such that they are not capable of dissipating significant power and the second coupling means are arranged such that they are capable indeed of dissipating significant power. | 2012-03-08 |
20120058853 | LUBRICATION SYSTEM FOR RIGHT-ANGLE DRIVES USED WITH UTILITY VEHICLES - A bearing lubrication device in a right angle gear reducer includes a gear housing having an interior portion and a lubricating fluid reservoir therein. An oil slinger, rotating pinion shaft, pinion shaft housing, and bearings for supporting the pinion shaft within the pinion shaft housing work together to provide a continuous supply of oil to the bearings. The pinion shaft includes two radially and longitudinally extending passageways therethrough which supply oil from a recess in one end of the pinion shaft to the bearings. Oil is slung from the reservoir into the recess of the rotating pinion shaft where it is forced outwardly and through the passageways to a chamber formed by the rotating pinion shaft, shaft housing and bearings. The roller bearings pump the oil from the chamber back to the fluid reservoir. Oil passageways in the shaft housing enable the return of oil from one bearing set. | 2012-03-08 |
20120058854 | TRANSMISSION DEVICE FOR WORK VEHICLES - Disclosed is a transmission device for work vehicles, said transmission device being capable of being used with high-horsepower engines, without an accompanying loss of power transmission efficiency or fuel economy. The transmission device is provided with: an input shaft ( | 2012-03-08 |
20120058855 | AXLE ASSEMBLY WITH TORQUE DISTRIBUTION DRIVE MECHANISM - An axle assembly with an input member, a first planetary gear set, a differential assembly, and a second planetary gear set. The first planetary gear set has a first transmission input that is driven by the input member. The differential assembly has a differential carrier and first and second differential output members received in the differential carrier. The second planetary gear set has a planet carrier coupled to the differential carrier for common rotation. A sun gear of the first planetary gear set is non-rotatably coupled to a sun gear of the second planetary gear set. | 2012-03-08 |
20120058856 | MULTI-SPEED TRANSMISSION - A transmission of the present invention has an input member, an output member, four planetary gear sets, a plurality of coupling members and a plurality of torque transmitting devices. Each of the planetary gear sets includes first, second and third members. The torque transmitting devices may include clutches and brakes. The torque transmitting devices are selectively engageable in combinations of at least two to establish at least nine forward speed ratios and at least one reverse speed ratio. | 2012-03-08 |
20120058857 | METHOD FOR OPERATING A DRIVE TRAIN - A method of operating a drive-train of a motor vehicle which comprises a hybrid drive with a combustion engine and an electric machine, a clutch connected between the combustion engine and the electric machine, a transmission connected between the electric machine and a drive output, and either a primary retarder connected between the electric machine and the transmission or a secondary retarder connected between the transmission and the drive output. In order to warm up hydraulic oil, when the clutch between the combustion engine and the electric machine is disengaged and a transmission gear is engaged, a braking torque is produced by either the primary or secondary retarder, in the drive-train, and the electric machine is operated in a torque-controlled manner such that it delivers a torque equal to the sum of a target torque determined in accordance with the driver's wish and the braking torque produced by either the primary or secondary retarder. | 2012-03-08 |
20120058858 | AUTOMOBILE DRIVING SYSTEM AND CONTROL METHOD THEREOF - An automobile driving system includes an engine and a transmission. The transmission includes a variable gear ratio mechanism and a gear ratio of the transmission can be set to infinity. A one-way clutch is provided at an output portion of the transmission. At a time of a engine stopping controller controlling to stop the engine, a transmission-and-control device uses inertia from the engine up to an input member of the one-way clutch as assisting force for driving operations of the variable gear ratio mechanism to change the gear ratio at the transmission to infinity or close to infinity, before the engine actually stops. | 2012-03-08 |
20120058859 | AUTOMATED WEIGHTLIFTING SPOTTING MACHINE - A weight training assistance apparatus which requires a user to overcome the force exerted by one or more weights comprising: one or more sensors for monitoring a user's activity by monitoring the position of an item indicative of the position of the weights during a weight training exercise; a processor in communication with said sensors; the processor enabled to dynamically compare the user's activity of the item during the exercise with a predetermined activity profile to determine a dynamic level of fatigue for the user; the processor further enabled to determine a response at a given moment based on the exercise undertaken, the current user activity and the determined dynamic level of fatigue; a load bearing device that is controllable by the processor, the load bearing device enabled to dynamically vary the magnitude of the net force exerted by the weight as determined by the response, the processor further enabled to maintain the magnitude of the force when the user's activity is within a predetermined limit of the predetermined activity profile. | 2012-03-08 |
20120058860 | Trunk rotation - This trunk rotation device uses dynamic movement of one's body such as, shoulder, hip, knee, back, thigh, and abdominal musculature. The device provides a method for exercising the spinal column and the muscles of the torso, including those in the abdominal lumbar and thoracic regions involving rotational torque. In a preferred embodiment, the device is a golf exercise and flexibility apparatus. The golf exercise apparatus provides resistance to a golfer during a golf swing to strengthen and condition the muscles of the axial skeleton of the golfer in a functional posture. | 2012-03-08 |
20120058861 | TACTILE EXERCISE MAT - The present invention relates to a tactile exercise mat ( | 2012-03-08 |
20120058862 | Stride adjustment mechanism - In an elliptical step exercise apparatus a dynamic link mechanism can be used to vary the stride length of the machine. A control system can also be used to vary stride length as a function of various exercise and operating parameters such as speed and direction as well as varying stride length as a part of a preprogrammed exercise routine such as a hill or interval training program. In addition the control system can use measurements of stride length to optimize operation of the apparatus. | 2012-03-08 |
20120058863 | RESISTANCE EXERCISE TRAINER HAVING PORTABLE HAND-HELD WEIGHTS - The soft weight strength trainer includes a selectively fillable pouch with a strap positioned so that a person can fit a hand or foot in-between the strap and the fillable pouch. The soft weight strength trainer can be utilized in a variety of exercises that strengthen various muscle groups. None of the exercises that are performed with the soft weight strength trainer require a close fisted grip, which makes the soft weight strength trainer ideal for use by a person with reduced hand strength due to age or injury. Additionally, the soft weight strength trainer will not cause damage or injury if inadvertently dropped due to its non-rigid construction. | 2012-03-08 |
20120058864 | Physical Work-Out Device with Adjustable Elastic Bands - A physical work-out apparatus comprised of a mechanism for shortening elastic bands, and one or more elastic bands that are integrated into the mechanism in such a way that enables a user to shorten or lengthen the elastic bands. The apparatus can be integrated and attached to a harness worn on the user's back and chest. The mechanism enables the user to shorten or lengthen, according to need, the elastic band or bands. | 2012-03-08 |
20120058865 | SKIING EXERCISE APPARATUS - An apparatus and method for exercising using an apparatus that includes an upper assembly, equipped with pedal platforms or a snowboard attachment, which is pivotally attached to a lower frame assembly. The lower frame assembly includes ski pole attachments that enable a user to maintain balance while using the apparatus. When the user stands on the pedals, elastic members coupled to the lower frame assembly and the upper frame assembly maintain level of the upper assembly while also providing some resistance to lateral movement. As the user shifts weight to simulate downhill skiing, the resistance by the elastic members, and an adjustable brake component, provide strength and core exercises similar to skiing. | 2012-03-08 |
20120058866 | PROGRESSIVE RESISTANCE EXERCISE DEVICE - A device is provided that includes a post, an arm assembly being pivotably connected to the post at one or more connection points, a set of beams comprising an upper beam set and a lower beam set, wherein the upper beam set and the lower beam set each comprise one or more beams, the set of beams being pivotably connected to the post, wherein the post is connected to the upper beam set and the lower beam set such that the lower beam set and the upper beam set are positioned at a first distance apart from one another at their connection point with the post, a platform being pivotably connected to the set of beams, wherein the platform is connected to the upper beam set and the lower beam set such that the lower beam set and the upper beam set are positioned at a second distance apart from one another at their connection point with the platform and a lift tube having a length and being pivotably connected to the upper beam set at one or more connection points and the arm assembly at one or more connection points. | 2012-03-08 |
20120058867 | ABDOMINAL EXERCISER WITH ROTATABLE SEAT AND TANDEM PULLEY FEATURES - An abdominal exerciser has base and back frames pivotally mounted for movement between upright and recumbent positions, and a seat frame with cushion rotatable on the base frame. A low friction journal between the base and seat frames supports a user's weight. The journal is about 30 to 42% the distance from a rear end of the cushion to its front end so the user's coccyx is vertically aligned with the journal. Arms at each side of the base frame have a pair of extensions connected to either the base or seat frame, each with a U-shaped handhold lying in a plane at an acute angle of about 30 to 80 degrees to the horizontal. A pair of single pulleys or a pair of tandem pulleys are mounted near the rear of the base frame and are engaged by sleeve-covered springs for biasing the back frame toward the upright position. | 2012-03-08 |
20120058868 | EXERCISE DEVICE - An exercise device for achieving desired abdominal contractions during exercise movement includes a back support and a pair of leg blades removably attached to the back support. The device includes a back blade attached to the back support and extending upward from the lower end along a centerline of the back support, and a neck support assembly attached to the back blade. | 2012-03-08 |
20120058869 | BACK MACHINE AND METHOD - A back machine and method that can be employed by individuals particularly those with chronic back pain to stretch the lower back muscles, realign and strengthen the lower spine and also to reduce pain. The back machine includes a base portion and a frame portion. The frame portion includes a lower end attached to the base portion. The frame portion extends in a vertical direction from the base portion to a height that is substantially above that of an average user standing upright on said base portion. The back machine includes a handle bar portion, a right foot support elevated above the base; a right leg restraint adjacent to the right foot support; a left foot support elevated above the base; and a left leg restraint restraining movement of a user's left leg when elevated. | 2012-03-08 |
20120058870 | EXERCISE APPARATUS AND METHODS OF USE - The present invention includes an exercise apparatus adapted to exercise a user's gluteus muscles. The exercise apparatus and method of use allow the user to focus on and exercise gluteus muscles with specificity. Embodiments of the exercise apparatus include an upper body support, a foot support, and an exercise space. The exercise space is typically disposed substantially between an upper body support and a foot support, and permits substantial movement of a user's hips in both a forward direction and a rearward direction, substantially in or parallel to a user's sagittal plane. The exercise apparatus is adapted to load a user's gluteus muscles throughout a generally large range of gluteus muscle flexion and extension. | 2012-03-08 |
20120058871 | MACHINE TOOL INCLUDING TOOL RADIUS ADJUSTING DEVICE - A tool radius adjusting device executes an operation for adjusting the tool radius of a boring holder in parallel with execution of a machining program for executing an operation of a spindle head and an operation of a tool changer. A carrier control unit determines whether the tool changer is executing a tool changing process. When the tool changing process is not being executed, the carrier control unit allows the carrier device to execute an operation for picking the boring holder out from the tool magazine and an operation for returning the boring holder, of which the tool radius has been adjusted, to the tool magazine. | 2012-03-08 |
20120058872 | MACHINE TOOL GUIDE CARRIAGE ASSEMBLY - The invention relates to a machine tool guide carriage assembly, comprising a first linear guide track having at least two first parallel guide rails, wherein a first carriage is mounted on the guide track in a linearly displaceable manner, which carriage surrounds a free space in which a second carriage can be linearly displaced at a right angle to the first guide track, wherein the free space is formed by two bearing elements that are arranged at a distance from each other. | 2012-03-08 |
20120058873 | Box making machines - A corrugated box making machine has a vacuum transfer mechanism for moving corrugated boards along a path of conveyance including stations having printing and die cutter mechanisms which operate on the boards. The printing mechanisms include a print and impression cylinder, the latter being mounted in a vacuum housing that also holds drive rolls for moving the boards along the path during which the boards are held against the rolls by vacuum in the housing. The latter is movable substantially above the print cylinder to provide convenient access for maintenance of the print cylinder or replacement of its printing plates. | 2012-03-08 |
20120058874 | DISPOSABLE CONTAINERS AND METHOD OF MAKING THE SAME - A polyhedron disposable container formed from flexible weldable plastic film and a method of forming the same are provided. The container has opposite ends and an openings that accommodates a port at the center of at least one of such ends. The container also has multiple sides and an opening on at least one such side located midway between the edges of such side. | 2012-03-08 |
20120058875 | Quarter folder apparatus - A quarter folder for signatures which has a deflector or guide means to maintain a side of the signatures in an arcuate configuration. | 2012-03-08 |
20120058876 | CRYSTALLIZED GLASS WITH NEGATIVE COEFFICIENT OF THERMAL EXPANSION AND METHOD FOR MANUFACTURING THE SAME - A crystallized glass with negative coefficient of thermal expansion includes 38 wt % to 64 wt % of silica (SiO2); 30 wt % to 40 wt % of alumina (Al2O3); and 5 wt % to 12 wt % of lithium oxide (Li2O) as a basic component, and further includes more than one component selected from the group consisting of 0.5 wt % to 15 wt % of zirconia (ZrO2), 0.5 wt % to 6.5 wt % of titanium dioxide (TiO2), 0.5 wt % to 4 wt % of phosphorus pentoxide (P2O5), 2 wt % to 5 wt % of magnesium oxide (MgO), and 0 wt % to 5 wt % of magnesium fluoride (MgF2) in addition to the basic components. The crystallized glass may have a high negative coefficient of thermal expansion so that it has an advantage that it can be used as a thermal expansion compensation material according to the temperatures of all kinds of glasses and similar products thereof. | 2012-03-08 |
20120058877 | LOW THERMAL EXPANSION FILLER, METHOD FOR PREPARING THE SAME AND GLASS COMPOSITION - An object of the present invention is to provide a low thermal expansion filler for low thermal expansion glasses which has a low coefficient of thermal expansion and exhibits superior flowability in a molten state, and a glass composition containing the same. | 2012-03-08 |
20120058878 | Low Dielectric Glass And Fiber Glass - Glass compositions are provided that are useful in a variety of applications including, for example, electronics applications, reinforcement applications, and others. Some embodiments of glass compositions can provide desirable dielectric constants, desirable dissipation factors, and/or desirable mechanical properties while also having desirable fiber forming properties. | 2012-03-08 |
20120058879 | Dark Neutral Green Gray Soda-Lime Glass Composition - The present invention relates to a dark neutral green gray soda-lime glass composition comprising, as a colorant ingredient per 100 weight parts of a base glass composition, 1.4 to 2.5 weight parts of total Fe | 2012-03-08 |
20120058880 | HIGH TRANSMITTANCE GLASS - A high transmittance glass includes: SiO | 2012-03-08 |
20120058881 | CERAMIC PRODUCT - The invention relates to a ceramic product, manufactured from a mixture made of natural and/or synthetic inorganic non-metal raw materials, at least one binder and optionally further additives. In order to provide ceramic products allowing for disadvantages known from the prior art to be eliminated, at least with respect to corrosion and erosion, it is proposed that the ceramic products are manufactured from a mixture comprising a) at least 10% by weight (based on the weight of all solids of the mixture) oxidic components, b) 0.05 to 2.7% by weight (based on the weight of all solids of the mixture) at least one organic-based binder, acting as a solubilizer in the mixture, and c) 3 to 10% by weight (based on the weight of all solids of the mixtures) hydrous dispersing agent, and that the ceramic product contains less than 0.1% by weight (based on the total weight of the ceramic product) of carbon after the use thereof at temperatures above 600° C. | 2012-03-08 |
20120058882 | CERAMIC NANOCOMPOSITE MATERIAL AND METHOD OF MANUFACTURING THEREOF - Ceramic nanocomposite and methods for manufacturing thereof. One method comprising: receiving a fired green ceramic body comprising ceramic matrix; introducing to the fired green ceramic body submicron particles; and introducing at least one type of location-controlling dopant at an amount that is sufficient to cover the majority of the ceramic matrix grain boundaries, as well as the majority of the interfaces between the submicron particles and the ceramic matrix grains but less than an amount that would result in a concentration that exceeds the bulk solubility limit of the location-controlling dopant ions in the ceramic matrix, at the ceramic nanocomposite sintering temperature. | 2012-03-08 |
20120058883 | HIGH-STRENGTH TRANSPARENT ZIRCONIA SINTERED BODY, PROCESS FOR PRODUCING THE SAME, AND USES THEREOF - Translucent zirconia sintered bodies have had a problem that incorporation of titania improves translucency but lowers mechanical strength. The invention provides: a zirconia sintered body containing titanium oxide, the sintered body containing 6-15 mol % yttria and 3-20 mol % titania and having an in-line transmission of 50% or higher when examined at a sample thickness of 1 mm and a measuring wavelength of 600 nm; and a zirconia sintered body having especially high translucency which is a high-quality transparent zirconia sintered body that contains 3-20 mol % titania and 6-15 mol % yttria and has an in-line transmission, as measured at a wavelength of 600 nm, of 73% or higher and a haze value of 2.0% or less and that is highly translucent and is undimmed (cloudless). The invention further relates to a production process in which a powder having the composition is molded and thereafter subjected to ordinary-pressure primary sintering and hot isostatic pressing (HIP) under specific conditions. | 2012-03-08 |
20120058884 | FIBER INCLUDING SILICA AND METAL OXIDE - Techniques for coating a fiber with metal oxide include forming silica in the fiber to fix the metal oxide to the fiber. The coated fiber can be used to facilitate photocatalysis. | 2012-03-08 |
20120058885 | METHODS AND APPARATUSES FOR DILUTE PHASE IMPREGNATION OF A MILLED SORBENT WITH A CHEMICAL COMPOUND IN AN AQUEOUS SOLUTION - The present disclosure relates to apparatus designed to impregnate a sorbent. In some embodiments apparatus of the disclosure may comprise a mixing vessel having either a conical mixing chamber or an cylindrical mixing chamber designed to increase the contact surface area and/or contact/residence time of a sorbent and impregnant to produce compositions comprising an impregnated sorbent. Apparatus of the disclosure may also comprise one or more atomizers operable to produce atomized droplets of impregnant. The disclosure also provides methods for impregnation of a milled sorbent or an un-milled sorbent. Methods of the disclosure provide several technical advantages and may be cost effective. Impregnant sorbent compositions produced by methods and/or apparatus of the disclosure may have higher concentrations of an impregnant, a more uniform distribution of an impregnant and may have a greater sorbent efficiency. | 2012-03-08 |
20120058886 | Nano-Linked Metallocene Catalyst Compositions and Their Polymer Products - The present invention provides polymerization catalyst compositions employing novel dinuclear metallocene compounds. Methods for making these new dinuclear metallocene compounds and for using such compounds in catalyst compositions for the polymerization and copolymerization of olefins are also provided. | 2012-03-08 |
20120058887 | METHOD FOR MAKING SINGLE-PHASE ANATASE TITANIUM OXIDE - This invention relates to methods of making single phase nanocrystalline titanium dioxide. It is hereby provided a method for preparing single-phase anatase type titanium dioxide photocatalyst having a particle size of nano level at near room temperatures without the need for a sintering process at high temperatures. | 2012-03-08 |
20120058888 | Method for manufacture of noble metal alloy catalysts and catalysts prepared therewith - The invention provides a method for manufacturing supported noble metal based alloy catalysts with a high degree of alloying and a small crystallite size. The method involves using polyol solvents as reaction medium and comprises a two-step reduction process in the presence of a support material. In the first step, the first metal (transition metal; e.g. Co, Cr, Ru) is activated by increasing the reaction temperature to 80 to 160° C. In the second step, the second metal (noble metal; e.g. Pt, Pd, Au) is added and the slurry is heated to the boiling point of the polyol solvent in a range of 160 to 300° C. The catalysts manufactured according to the method are used as electrocatalysts for polymer electrolyte membrane fuel cells (PEMFC), direct-methanol fuel cells (DMFC) or as gas phase catalysts for CO oxidation or exhaust gas purification. | 2012-03-08 |
20120058889 | Composition containing carbon nanotubes, catalyst for producing carbon nanotubes, and aqueous dispersion of carbon nanotubes - Disclosed is a composition containing carbon nanotubes which meets all of the following conditions (1) to (4). (1) When observed via transmission electron microscopy, at least 50 out of every 100 carbon nanotubes are double-walled carbon nanotubes. (2) The carbon nanotubes have an average outer diameter in the range of 1.0 to 3.0 nm. (3) During thermogravimetric analysis under atmosphere at a temperature increase rate of 10° C./minute, a high temperature combustion peak is at 700 to 850° C., and the relationship between low temperature weight loss (TG(L)) and high temperature weight loss (TG(H)) is TG(H)/(TG(L)+TG(H))≧0.75. (4) The composition containing carbon nanotubes has a volume resistance value between 1.0×10 | 2012-03-08 |
20120058890 | METHODS FOR INDIVIDUALIZING TRICHOMES - A method for individualizing a trichome from an epidermis of a non-seed portion of a trichome-bearing plant in the | 2012-03-08 |
20120058891 | Oxadizine-Substituted Arylamides - Novel dioxazine- and oxdiazine-substituted arylamides of the formula (I) | 2012-03-08 |
20120058892 | N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)ARYLCARBOXAMIDES AND THEIR USE AS HERBICIDES - N-(Tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of the formula (I) are described as herbicides. | 2012-03-08 |
20120058893 | HERBICIDALLY ACTIVE KETOSULTAMS AND DIKETOPYRIDINES - Ketosultams and diketopyridines of the formula (I) and use thereof as herbicides are described. | 2012-03-08 |
20120058894 | SYNERGISTIC COMBINATIONS WHICH ARE COMPATIBLE WITH CULTIVATED PLANTS AND WHICH COMPRISE HERBICIDES SELECTED FROM THE GROUP CONSISTING OF BENZOYLCYCLOHEXANEDIONES FOR USE IN RICE CROPS - Synergistic combinations are provided which are compatible with cultivated plants and which comprise herbicides selected from the group consisting of benzoylcyclohexanediones for use in rice crops | 2012-03-08 |
20120058895 | COMPOSITIONS AND METHODS FOR CONTROLLING PESTS WITH GLYCOLIPIDS - Biosurfactants produced by microbes are used to control pests. The biosurfactants can be produced by cultivating a biosurfactant-producing microbe, producing a fermentation broth, and obtaining the biosurfactant from the fermentation broth. Alternately, the biosurfactants can be produced in situ in the environment of the pests by applying a carbon substrate to the pests' environment, which permits naturally-occurring biosurfactant-producing microbes to grow and to generate the biosurfactants. The biosurfactants have pesticidal qualities, and can be used to control a variety of pests, while being biodegradable and otherwise avoiding adverse environmental effects that have often been associated with conventional synthetic pesticides. | 2012-03-08 |
20120058896 | HERBICIDAL COMPOSITION - The present invention relates to a herbicidal composition having a synergistic herbicidal effect against weeds, said herbicidal composition including 3-[(5-difluoromethoxy-1-methyl-3-trifluoromethylpyrazol-4-yl)methylsulfonyl]-4,5-dihydro-5,5-dimethylisoxazole and salts thereof as a component A and a component B selected from the group consisting of paraquat, ametryn, acetochlor, clodinafop-propargyl, diclofop-methyl, cycloxydim, tepraloxydim, tralkoxydim, amidosulfuron, mesosulfuron-methyl, sulfosulfuron, tribenuron-methyl, imazamethabenz-methyl, imazamox, imazapic, florasulam, hexazinone, chlorotoluron, pyraflufen-ethyl, metazachlor, S-metolachlor, isoxaben, fluroxypyr, qinclorac and pinoxaden. | 2012-03-08 |
20120058897 | Auxin Herbicide Composition - An aqueous liquid herbicide composition comprising a solution of at least one of 2,4-D and dicamba in the form of the monomethylamine salt and at least one of 2,4-D and dicamba in the form of the dimethylamine salt wherein the molar ratio of monomethylamine to dimethylamine is in the range of from 1:20 to 4:6. | 2012-03-08 |
20120058898 | HERBICIDE RESISTANT SUNFLOWER PLANTS - Sunflower plants having increased resistance to herbicides relative to wild-type sunflower plants are provided. These plants contain a new genetic mutation in the AHAS gene which confers broad-spectrum resistance to AHAS-inhibiting herbicide. An herbicide-tolerant sunflower crop production system and new and powerful weed control option for sunflower growers are provided. | 2012-03-08 |
20120058899 | HERBICIDAL COMPOSITIONS - Crystal growth of cloquintocet mexyl hydrate is inhibited by polymeric carboxylate compounds. | 2012-03-08 |
20120058900 | HARDWARE ARCHITECTURE OF ANALYZERS - An analytical apparatus and a method for isolating and analyzing at least one analyte are described, comprising at least one module for receiving and dispensing a sample to be analyzed, at least one module for isolating said analyte to be analyzed, at least one module for analyzing said analyte, wherein said modules (i) to (iii) are arranged along an axis. | 2012-03-08 |
20120058901 | ASSAY FOR THE DETECTION OF RECURRENCE IN BREAST CANCER USING THE NOVEL TUMOR SUPPRESSOR DEAR1 - Certain aspects of the present invention relate to new diagnostic and prognostic methods involving DEAR1, a gene is located on the short arm of human chromosome 1. Specifically, analysis of expression or structure of this gene for prognosis or recurrence risk assessment is disclosed. | 2012-03-08 |
20120058902 | METHOD OF MEASURING ADAPTIVE IMMUNITY - Compositions and methods for measuring adaptive immune receptor (T cell receptor and immunoglobulin) diversity are described, and find uses for assessing immunocompetence and other purposes. Means are provided for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. Lymphoid (B- and T-cell) adaptive immune receptor diversity is quantified by calculating the number of uniquely rearranged, CDR3-containing immunoglobulin (Ig) or T-cell receptor (TCR) variable region-encoding genes from sample cells such as blood cells. | 2012-03-08 |
20120058903 | Gel Microdrop Composition and Method of Using the Same - A gel microdrop composition is provided. In certain embodiments, the gel microdrop composition contains a polymer matrix, an effector particle that releases an effector molecule into the polymer matrix, a first reporter particle that emits a first optically detectable signal and a second reporter particle that emits a second optically detectable signal that is distinguishable from the first optically detectable signal, where the effector particle and said first and second reporter particles are encapsulated by the polymer matrix. Methods of screening that employ the gel microdrop composition and methods of making the gel microdrop composition are also disclosed. | 2012-03-08 |
20120058904 | SPECIES-SPECIFIC PRIMER SETS AND IDENTIFICATION OF SPECIES-SPECIFIC DNA SEQUENCES USING GENOME FRAGMENT ENRICHMENT - Targeted sequencing of genetic regions that differ between two DNA preparations uses genomic fragment enrichment. This method can be used to study genetic variation among closely related species and microbial communities, particularly for identifying sources of fecal pollution. | 2012-03-08 |
20120058905 | DNA Sequences Encoding Caryophyllaceae and Caryophyllaceae-Like Cyclopeptide Precursors and Methods of Use - Naturally-occurring and modified recombinant nucleic acid molecules have been isolated that encode linear pre-cursors of cyclopeptides of the Caryophyllaceae (Ccps) and Caryophyllaceae-like (Clcps) type V1 class of cyclopeptides. Such nucleic acid molecules are useful for producing cyclopeptides and their linear precursors by recombinant methods. | 2012-03-08 |
20120058906 | COMBINATORIAL ANTIBODY LIBRARIES AND USES THEREOF - Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided. | 2012-03-08 |
20120058907 | Mixtures of binding proteins - Described are methods for producing libraries of cells expressing at least two separate single polypeptide chain binding proteins, in which the binding proteins have different target epitopes. Such libraries are made by integration of the nucleic acid sequences encoding the polypeptide chains into the genome of the host cell, and selecting for cells that have successfully integrated these nucleic acids. The selected cells are preferably subjected to a cloning step. Mixtures of binding proteins are produced without having to individually produce each of the components of the mixture. A library of cells wherein essentially each cell encodes at least two single polypeptide chain binding proteins having different target epitopes is also herewith provided, as well as methods for producing a composition comprising at least two separate single polypeptide chain binding proteins having different target epitopes. | 2012-03-08 |
20120058908 | Universal Tags, Probes and Detection Methods For Multiple Targets Detection of Biomolecules - The present invention provides universal tags, probes and detection methods for multiple targets detection of biomolecules. The universal tag in the present invention is a fragment of DNA, RNA, peptide nucleic acid, or LNA, and is 3-20 mer in length. The probe in the present invention contains in order from 3′ terminus to 5′ terminus, a nucleotide sequence which is reverse complementary to a target molecule or a portion of the target molecule, and a nucleotide sequence which is reverse complementary to the universal tag; or said probe contains in order from 3′ terminus to 5′ terminus, a nucleotide sequence which is reverse complementary to the universal tag, and a nucleotide sequence which is reverse complementary to a target molecule or a portion of the target molecule. | 2012-03-08 |
20120058909 | IL-17 HOMOLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF - The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases. | 2012-03-08 |
20120058910 | METHOD FOR DIAGNOSING ACUTE LYMPHOMIC LEUKEMIA (ALL) USING MIR-125b - Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins. | 2012-03-08 |
20120058911 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-181b - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 2012-03-08 |
20120058912 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING let-7g - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 2012-03-08 |
20120058913 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-16b - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 2012-03-08 |
20120058914 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-203 - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 2012-03-08 |
20120058915 | METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-10a - The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis. | 2012-03-08 |
20120058916 | DIAGNOSTIC METHODS FOR LIVER DISORDERS - The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein. | 2012-03-08 |
20120058917 | Nucleic Acids and Libraries - The invention relates to a nucleic acid comprising the following contiguous elements arranged in the 5 prime to 3 prime direction; a promoter; a selectable marker; a cloning site for receipt of a nucleic acid segment, said segment comprising a candidate miRNA target sequence; and a poly adenylation signal, said elements arranged such that a transcript directed by said promoter comprises said selectable marker, said candidate miRNA target sequence, and said poly adenylation signal in that order. Suitably the miRNA test sequence is or is derived from a 3′UTR. The invention also relates to methods for making and screening libraries. | 2012-03-08 |
20120058918 | CELL LINES EXPRESSING CFTR AND METHODS OF USING THEM - Disclosed herein are cells and cell lines that stably express CFTR and methods for using those cells and cell lines. The invention also includes techniques for creating these cells and cell lines. The cells and cell lines of this invention are physiologically relevant. They are highly sensitive and provide consistent and reliable results in cell-based assays. | 2012-03-08 |
20120058919 | Method For Rapid Detection And Evaluation Of Cultured Cell Growth - Provided is a method and growth chamber for the rapid and accurate detection of growth and metabolism of a cellular microorganism in isolation within one or a plurality of wells containing a population of microorganisms in a non-liquid, culture medium, wherein the cells are distributed at not greater than one cell per well at plating. Further provided is a gelled culture medium containing a non-toxic, water-soluble, phosphorescent compound which measures oxygen content (partial oxygen pressure) of a microorganism also contained therein, by oxygen-dependent quenching of phosphorescence; or the gel contains a fluorescent pH indicator that demonstrates growth of the microorganism by pH-dependent intensity change or wavelength shift in the emission spectrum. | 2012-03-08 |
20120058920 | Method for Identifying Inhibitors Against Dengue Virus - The present invention concerns a method for identifying inhibitors against dengue virus subtypes 1, 2, 3 or 4 and its use in a high throughput mode. | 2012-03-08 |
20120058921 | PROCESS FOR PRODUCING A PURIFIED SYNTHESIS GAS STREAM - A process for producing a purified synthesis gas stream from a feed synthesis gas stream comprising besides the main constituents carbon monoxide and hydrogen also hydrogen sulphide, HCN and/or COS, the process comprising the steps of: (a) removing HCN and/or COS by contacting the feed synthesis gas stream with a catalyst in a HCN/COS reactor in the presence of steam/water, to obtain a synthesis gas stream depleted in HCN and/or in COS; (b) converting hydrogen sulphide in the synthesis gas stream depleted in HCN and/or in COS to elemental sulphur, by contacting the synthesis gas stream with an aqueous reactant solution containing solubilized Fe(III) chelate of an organic acid, at a temperature below the melting point of sulphur, and at a sufficient solution to gas ratio and conditions effective to convert H | 2012-03-08 |
20120058922 | NOVEL FORMULATIONS OF WATER-SOLUBLE POLYMERS AND STABILIZING ADDITIVES FOR INJECTING A SINGLE COMPOUND USEABLE IN INJECTION FLUIDS FOR CHEMICAL ENHANCED OIL RECOVERY - Composition based on anionic polymers or water-soluble amphoteric (co)polymers suitable for viscosifying the injection fluids for oil recovery, characterized in that, before dilution with the injection fluid, it further contains at least 3 stabilizing agents selected from the group comprising oxygen reducing agents, precipitating agents, free radical scavengers, complexing agents and sacrificial agents, the said stabilizing agent being suitable for preventing the chemical degradation of the polymer once the polymer is introduced into the injection fluid. | 2012-03-08 |
20120058923 | Self-Lubricating Surface Coating Composition for Low Friction or Soft Substrate Applications - A bearing having a surface and a self-lubricating surface coating composition deposited on the surface, wherein the self-lubricating surface coating composition includes a curable acrylate composition having a metallic composition. The metallic composition having a metallic acrylate compound according to Formula I: | 2012-03-08 |
20120058924 | WORKING FLUID FOR BRITTLE MATERIAL AND WORKING FLUID FOR HARD MATERIAL - Provided is a water-containing working fluid for a brittle material and a hard material, which includes (A) water, (B) a water soluble polymeric compound having an oxygen-containing group and a number average molecular weight of 6,000 to 3,000,000, and (C) a nonionic surfactant having a clouding point of 10 to 70° C. in a 1% by mass aqueous solution. In a loose-abrasive grain method, the working fluid allows a slurry thereof to be supplied into the working gap sufficiently and has excellent abrasive grain dispersion stability and excellent properties to wash and disperse cutting swarf. In a method using a fixed-abrasive grain wire saw, the working fluid rarely causes detachment of the fixed abrasive grains and has excellent properties to wash and disperse cutting swarf. | 2012-03-08 |
20120058925 | WATER-SOLUBLE PROCESSING OIL AGENT - To provide a water-soluble working fluid which less adversely affects the human body and the ecological system as compared with conventional water-soluble working fluids, which has high rotting resistance, and which provides excellent working performance. | 2012-03-08 |
20120058926 | POLY PHOSPHATE FUNCTIONALIZED ALKYL POLYGLUCOSIDES FOR ENHANCED FOOD SOIL REMOVAL - A cleaning composition including a primarily C | 2012-03-08 |
20120058927 | Bleach Granules Comprising An Active Coating - The invention relates to co-granules containing a granule core and a sheath or coating layer surrounding the granule core. Said co-granules are characterised in that the granule core contains a) at least one bleach activator, a2) between 0 and 20 wt. % of the total quantity of at least one bleach catalyst contained in the co-granule, and c) at least one binding agent, and the sheath or coating layer contains d) between 80 and 100 wt. % of the total quantity of the at least one bleach catalyst contained in the co-granule, and e) at least one coating agent. The co-granules are advantageously suitable for producing cleaning products and detergents and especially products for washing crockery in a machine. | 2012-03-08 |
20120058928 | Alkaline Protease Variants - An alkaline protease variant derived from an alkaline protease consisting of an amino acid sequence represented by SEQ ID NO: 2 or consisting of an amino acid sequence having an identity of 90% or more therewith, which variant has mutations wherein one or more amino acid residues at positions selected from (a) position 6, (b) position 15, (c) position 16, (d) position 65, (e) position 66, (f) position 82, (g) position 83, (h) position 204, (i) position 319, and (j) position 337 of the amino acid sequence represented by SEQ ID NO: 2, or at positions corresponding thereto are substituted with the following amino acid residues: (a) or a position corresponding thereto: Typ, Leu, Val, Ile, Met, Tyr, Gln, Lys, Thr, Phe, Arg, Ser, Cys, Ala, or His; (b) or a position corresponding thereto: Glu, Met, Asp, Val, Gln, Arg, Cys, Trp, Ala, or Phe; (c) or a position corresponding thereto: Met, Glu, Arg, Val, Lys, Phe, Tyr, Ile, His, Asp, or Cys; (d) or a position corresponding thereto: Trp; (e) or a position corresponding thereto: His, Trp, Ser, or Leu; (f) or a position corresponding thereto: Ala, Glu, Gln, Ser, Cys, Gly, H is, Lys, Arg, Met, or Asn; (g) or a position corresponding thereto: Ala, Ser, or Cys; (h) or a position corresponding thereto: Glu, Asp, Cys, Val, Thr, Pro, His, Ile, Trp, Ser, Asn, Lys, or Arg; (i) or a position corresponding thereto: Trp, Val, Thr, Leu, Ile, Cys, Glu, Lys, Tyr, Arg, Phe, Gln, Met, Pro, Asp, Asn, H is, or Ser; and (j) or a position corresponding thereto: Arg, Gly, Ser, Lys, Gln, Thr, His, Ala, Cys, or Val. | 2012-03-08 |
20120058929 | CARRIER SYSTEM FOR FRAGRANCES - The present invention relates to a carrier system for fragrances, to the production thereof and to the use of the carrier system in various fields of industry. | 2012-03-08 |
20120058930 | POLYPEPTIDES HAVING LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 2012-03-08 |
20120058931 | Drug target that promotes secretory granule-granule fusion - Munc18 proteins facilitate formation of SNARE complexes known to mediate membrane fusion. Much is known about the fusion of secretory granule (SG) to plasma membrane, mediated by Munc18a-SNARE complexes. It has been found that another Munc18 isoform, Munc18b, mediates SG-SG fusion which causes potentiation of secretion. The present invention has identified specific site mutations within Munc18b which further increased (called KR mutant) or reduced (called E59K mutant) SG-SG fusion compared to wild type (WT) Munc18b, causing amplification or reduction of insulin secretion, respectively. Compounds identified that mimic the actions of Munc18b-WT and Munc18b-KR mutant which increase SG-SG fusion, and those which mimic Munc18b-E59K mutant that block SG-SG fusion, are useful for treating and/or preventing diseases and/or conditions, whose underlying bases are a deficiency or excess of SG-SG fusion, respectively. These compounds also include conserved domains in Munc18a and Munc18c that mimic the KR and E59K sites in Munc18b. | 2012-03-08 |
20120058932 | ACTIVE INGREDIENT-PEPTIDE CONSTRUCT FOR EXTRACELLULAR CONCENTRATION - The present invention relates to an active ingredient-peptide construct for extracellular concentration, a process for the concentration of active ingredients in an extracellular space of a multicellular object, the use of the active ingredient-peptide construct according to the invention for the production of a medicinal product and a pharmaceutical composition containing the active ingredient-peptide construct according to the invention. | 2012-03-08 |
20120058933 | SYNTHETIC PEPTIDES AND PEPTIDE MIMETICS - The present invention provides Parotid Secretory Protein peptides, nucleic acids encoding the peptides, and methods of using the peptides, and methods of screening GL13 mimetics. | 2012-03-08 |
20120058934 | TREATMENT OF DISEASES - The invention provides a method of inhibiting vascular hyperpermeability in an animal in need thereof. The method comprises administering an effective amount of a diketopiperazine, a prodrug of a diketopiperazine or a pharmaceutically-acceptable salt of either of them to the animal, wherein the diketopiperazine has the formula set forth in the specification. | 2012-03-08 |
20120058935 | ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEREFORE - The invention features antimicrobial compositions comprising β-amyloid peptides, oligomers, and analogs thereof, and methods of using them for the prevention or treatment of an infection. | 2012-03-08 |
20120058936 | COMPOSITIONS AND METHODS FOR ELIMINATION OF GRAM NEGATIVE BACTERIA - Oral drug delivery formulations which specifically administer antibacterial agents to the ileum, caecum, and/or the colon, without significant administration elsewhere in the gastrointestinal tract, are disclosed. The formulations include, as actives, a combination of a macrolide or aminoglysoside, or quinolone antibacterial and an anti-Gram-negative lipopeptide (polymyxin) antibacterial agent or other peptide antibacterials effective against Gram-negative bacteria. The formulations can be used to treat infections or unwanted colonization in the colon, and to provide effective decontamination of the colonic flora from unwanted or potentially pathogenic bacteria. | 2012-03-08 |
20120058937 | Prodrugs of Neuraminidase Inhibitors - A new class of neuramidase inhibitor prodrugs is provided characterized by a prodrug moiety of a carboxyl group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide or a carbonyl ethoxy tripeptide, a guanidine group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide, a carbonyl ethoxy tripeptide; a primary alcohol modified to form an esterified single amino acid, dipeptide or tripeptide of zanavimir of the unaltered therapeutic agent. Exemplary therapeutic agents so modified to form prodrugs include zanavimir, oseltamivir and peramivir. The prodrug has increased oral bioavailability relative to the unaltered neuraminidase inhibitor and is effective in the inhibition of viral infections involving neuraminidase in the viral reproductive cycle. | 2012-03-08 |
20120058938 | NUTRITIONAL COMPOSITION INDUCING A POSTPRANDIAL ENDOCRINE RESPONSE - The invention concerns the use of a nutritional composition for the treatment of disorders which are associated with malfunctioning in the uptake and use of food-derived energy in the human body. In particular, the invention concerns the use of a nutritional composition for the treatment of a disorder, which is mediated by a postprandial endocrine or neurological response in a human body, wherein the nutritional composition comprises one or more of a specific protein fraction, a specific carbohydrate fraction and a specific nutritional fiber fraction. | 2012-03-08 |
20120058939 | AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF - Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention. | 2012-03-08 |