08th week of 2014 patent applcation highlights part 31 |
Patent application number | Title | Published |
20140050614 | T-PIECE FOR CREATING TURBULENCE - Extracorporeal blood treatment methods are usually performed with anticoagulation of the blood. In regional anticoagulation with citrate, sometimes a blood clot is observed in the extracorporeal circulation at the point of addition of the calcium substitution solution. In such a case, the treatment must be interrupted. To prevent this, a spiral structure is provided for generating turbulence in the present addition point according to the invention in the form of a T-piece. | 2014-02-20 |
20140050615 | SYSTEMS AND METHODS FOR SALVAGING RED BLOOD CELLS FOR AUTOTRANSFUSION - Systems and methods for salvaging blood cells from an absorbent material are disclosed. In one exemplary aspect, such as system includes a rotatable basin having perforations to allow rinse solution from a stationary basin to reversibly flow therethrough to wash the blood cells from the absorbent material, thereby forming an effluent solution. The system further includes a hemoconcentrator in fluid communication with the stationary basin having first and second fluid outputs for discharging a diluent solution and a blood cell discharge solution from the effluent solution respectively. The blood cells can be salvaged from the blood cell discharge solution. The second fluid output is in fluid communication with the stationary basin for recycling the diluent solution as the rinse solution. | 2014-02-20 |
20140050616 | MONITORING SYSTEM FOR CARDIAC SURGICAL OPERATIONS WITH CARDIOPULMONARY BYPASS - A monitoring system for cardiac operations with cardiopulmonary bypass comprising: a processor operatively connected to a heart-lung machine; a pump flow detecting device connected to a pump of the heart-lung machine to continuously measure the pump flow value and send it to the processor; a hematocrit reading device inserted inside the arterial or venous line of the heart-lung machine to continuously measure the blood hematocrit value and to send it to the processor; a data input device to allow the operator to manually input data regarding the arterial oxygen saturation and the arterial oxygen tension; computing means integrated in the processor to compute the oxygen delivery value on the basis of the measured pump flow, the measured hematocrit value, the preset value of arterial oxygen saturation, and the preset value of arterial oxygen tension; and a display connected to the processor to display in real-time the computed oxygen delivery value. | 2014-02-20 |
20140050617 | DUAL OUTLET OXYGENATOR FOR TREATING BLOOD IN AN EXTRACORPOREAL BLOOD CIRCUIT - An apparatus for oxygenating blood including a housing and an oxygenator bundle. The housing defines a primary chamber, a blood inlet port open to the primary chamber, and a blood outlet region. The outlet region includes a blood outlet port, an outlet chamber open to the outlet port, and a partition. The partition establishes spaced apart, first and second passageways from the primary chamber to the outlet chamber. The oxygenator bundle is disposed within the primary chamber. A blood flow path is formed from the blood inlet port, through the oxygenator bundle and to the blood outlet port, and includes first and second outlet flow paths within the outlet chamber via the first and second passageways, respectively. The first and second outlet blood flow paths merge at the blood outlet port. A dual port blood outlet is created, increasing mixing of blood immediately upstream of the outlet port. | 2014-02-20 |
20140050618 | APPARATUS FOR MAKING EXTRACORPOREAL BLOOD CIRCULATION AVAILABLE - The present invention relates to an apparatus for making extracorporeal blood circulation available, in particular a heart-lung machine, comprising a venous connection and an arterial connection, between which a blood reservoir, a blood pump and a bubble detector for the detection of air bubbles are provided, with, downstream of the bubble detector, an arterial line leading to the arterial connection via an arterial clamp and a bypass leading via a bypass clamp back into the blood reservoir which is connected to a pump extracting air from the blood reservoir. In addition, the present invention relates to a method of operating such an apparatus. | 2014-02-20 |
20140050619 | Reaction Vessel - A reaction vessel ( | 2014-02-20 |
20140050620 | METHODS AND SYSTEMS TO COLLECT A BIOLOGICAL SAMPLE - Sample processing methods and systems to collect a biological sample. A device may be configured collect a predetermined volume of a sample in sample chamber, and seal the chamber upon activation. The device may be further configured to mix the mix the sample with a predetermined volume of a reagent and/or mix the sample and the reagent in a pre-determined ration. | 2014-02-20 |
20140050621 | BIOSENSOR AND BIOMATERIAL DETECTION APPARATUS INCLUDING THE SAME - Provided are a biosensor and a biomaterial detection apparatus including the same. The biomaterial detection apparatus comprises a light source to provide quantized photons; a substrate spaced apart from the light source; a single photonic sensor layer disposed on the substrate to sense the photons; and an adsorption layer disposed to cover the single photonic sensor layer, allow the photons to pass therethrough, and adsorb a biomaterial between the light source and the substrate. | 2014-02-20 |
20140050622 | SAMPLE ANALYZER - Each of a first measurement unit and a second measurement unit (sample analyzer) includes: a reagent storage section in which a plurality of holder parts are arranged side by side, each of the holder parts including a setting part in which a reagent container having an RFID tag attached thereto is set, and an antenna part which transmits/receives a radio wave to/from the RFID tag of the reagent container set in the setting part; and a left face part and a right face part which block a radio wave communication path between the antenna part of one of the holder parts and the RFID tag of the reagent container set in another one, of the holder parts, adjacent to the one of the holder parts. | 2014-02-20 |
20140050623 | APPARATUS FOR DETECTING DETERIORATION OF NOX SELECTIVE REDUCTION CATALYST - Apparatus for detecting deterioration of an NOx selective reduction catalyst in an exhaust passage of an internal combustion engine with improved accuracy, includes an NOx purification rate calculation unit for calculating the NOx purification rate in the NOx selective reduction catalyst based on the NOx concentration in the exhaust gas flowing into and out of the NOx selective reduction catalyst. A determination as to whether the NOx selective reduction catalyst is deteriorated is made based on the NOx purification rate at a time when the temperature of the NOx selective reduction catalyst is equal to or higher than a temperature (Tc | 2014-02-20 |
20140050624 | Vacuum Truck Scrubber System - A system and method scrub a vapor. In embodiments, a vacuum truck scrubber system includes a liquid vat, a first carbon canister, a second carbon canister, and a third carbon canister. The first carbon canister and the second carbon canister each contain carbon. The liquid vat is connected to the first carbon canister. The first carbon canister is connected to the second carbon canister. A vapor having contaminants is fed to the liquid vat and is introduced from the liquid vat to the first carbon canister wherein a portion of the contaminants is removed from the vapor. The vapor is introduced from the first carbon canister to the second carbon canister wherein another portion of the contaminants is removed. The vacuum truck scrubber system also includes a monitoring system for reading and recording of sample measurements in the first carbon canister, the second carbon canister and the third carbon canister. | 2014-02-20 |
20140050625 | Hydrogen Generator Having Liquid Delivery Member - A hydrogen generator is provided for generating hydrogen gas for a fuel cell stack. The hydrogen generator includes container, and a first reactant storage area configured to contain a liquid first reactant. The hydrogen generator also includes a reaction area and a solid second reactant within the reaction area, and a hydrogen outlet. The hydrogen generator further includes a flexible liquid delivery member extending into the reaction area and configured to deliver liquid reactant from the first reactant storage area to the reaction area. The flexible liquid delivery member includes a flexible portion that flexes to allow the delivery member to move with the solid second reactant as the second reactant is consumed. | 2014-02-20 |
20140050626 | CATALYTIC FILTER MODULE AND CATALYTIC FILTER SYSTEM COMPRISING SAME - A catalytic filter module for gaseous fluids is disclosed comprising a block-shaped filter element, a catalytic element and a clean gas collecting and discharge arrangement. The catalytic element is substantially coextensive with the filter element, said filter element has a feed face and on its opposite side a discharge face from which filtrate exits to be received by the upstream face of the catalytic element. The gaseous fluid exits the catalytic element as clean gas at a clean gas face thereof opposite to the upstream face. The clean gas collecting and discharge arrangement comprises one or more channels extending across the whole clean gas face of the catalytic element deflecting and directing the clean gas flow transverse to the vertical of the clean gas face of the catalytic element to a clean gas discharge opening of the filter module at a side face thereof. | 2014-02-20 |
20140050627 | OFF GAS PURIFICATION DEVICE - An exhaust gas purification catalyst apparatus. The apparatus has a noble metal component for oxidizing NOx in an exhaust gas discharged from a diesel engine, a reducing agent spraying means for supplying the reducing agent selected from a urea component or an ammonia component, and a selective reduction catalyst (SCR) not comprising a noble metal for removing by reduction NOx by contacting with the reducing agent, in this order from the upstream side of an exhaust gas passage. Activity of the selective reduction catalyst (SCR) is maintained by setting that the noble metal component of the oxidation catalyst (DOC) comprises platinum and palladium, and ratio of platinum particles existing alone is 20% or less, or average particle diameter of the noble metal is 4 nm or larger, and by suppressing volatilization of platinum from the oxidation catalyst (DOC), even when catalyst bed temperature increases up to 900° C. | 2014-02-20 |
20140050628 | EXHAUST GAS PURIFICATION APPARATUS FOR INTERNAL COMBUSTION ENGINE - In an exhaust gas purification apparatus for an internal combustion engine which is provided with a selective reduction type catalyst disposed in an exhaust passage of the internal combustion engine, a reducing agent supply device for supplying an ammonia derived reducing agent to a portion of the exhaust passage at the upstream side of the selective reduction type catalyst, and a mixing device disposed in a portion of the exhaust passage at the upstream side of the selective reduction type catalyst and at the downstream side of the reducing agent supply device, the present invention has a problem to remove solid matter derived from the reducing agent, which is adhered to or deposited on the mixing device, in a suitable manner. In order to solve this problem, the present invention has a temperature raising device disposed in a portion of the exhaust passage upstream of said mixing device so as to blow a flame to said mixing device. | 2014-02-20 |
20140050629 | LAYERED COMPLEX OXIDE, OXIDATION CATALYST AND DIESEL PARTICULATE FILTER - Provided are a layered complex oxide that can lower PM oxidation temperature and increase oxidation rate, and a nitrogen oxides reduction catalyst, a three-way catalyst, a DPF and an oxidation catalyst, each of which includes the layered complex oxide. The layered complex oxide has a layered perovskite structure and has a composition represented by the formula: (Ln | 2014-02-20 |
20140050630 | MICROREACTOR FOR PHOTOREACTIONS - A microreactor for photoreactions includes a housing upper part, a lid plate made of a material that allows transmission of light, a flow path plate made of a material that suppresses light reflection and has a high thermal conductivity, and a housing lower part. Light is applied through a window of the housing upper part and the lid plate to a flow path of the flow path plate. The lid plate made of the material that allows transmission of light and the flow path plate made of the material that suppresses light reflection and has a high thermal conductivity are welded each other to form an integrated body. | 2014-02-20 |
20140050631 | DEVICE FOR TREATING GASES USING SURFACE PLASMA - A device for treating gases using surface plasma, including:
| 2014-02-20 |
20140050632 | FLUX ADDITION AS A FILTER CONDITIONER - Improvements in a gasification system and process for gasifying carbonaceous feedstock with improved energy efficiency. Improved methods and systems for more efficient removal of particulates from a raw synthesis gas while simultaneously providing a novel mechanism for fluxing agent addition to the gasification reactor. A conditioning agent, in the form of coarse fluxing agent particles, is added to the raw synthesis gas upstream from the particle filtration unit. The conditioning agent allows more rapid turnaround of the filtration unit following filter element replacement, extend filter life, facilitates the removal of filter cake from the particle filters, and combines with removed filter cake for recycling to the gasifier. Addition of fluxing agent via this route eliminates the need to premix fluxing agent with the carbonaceous feedstock, thereby maximizing the rate of feedstock addition to the gasification reactor. | 2014-02-20 |
20140050633 | Device for Multi Phase and Single Phase Contacting - A multiphase contacting stage is provided that includes a first rotatable disc having a hollow disc-shaped cavity, an input port and an output port, and a second rotatable disc, where the second rotatable disc has a channeled cavity, an input port and an output port, and is disposed in the hollow disc-shaped cavity of the first rotatable disc, where the first rotatable disc and said second rotatable disc are concentric about an axis, where the multiphase contacting stage operates to integrate centrifugal separation and countercurrent mass transfer of a material for separation. | 2014-02-20 |
20140050634 | STEAM STERILIZER - A sterilizer having a cassette for holding metal instruments or medical devices. The cassette includes a metallic container that defines a sterilization chamber. The container has at least one outer surface. A plurality of spaced-apart, elongated rails extend along the at least one outer surface of the container. Each of the rails includes a free, longitudinal edge wherein the edges of the rails lie in a first plane. An insulating shell encases the metallic container and the plurality of rails. An outer surface of the insulating shell lies in the first plane. A receiving unit includes a housing having an outer surface and an inner surface. The inner surface engages the edges of the rails and the outer surface of the insulating shell when the cassette is disposed within the inner housing. A plurality of spaced-apart elongated ribs extends along the outer surface of the housing. | 2014-02-20 |
20140050635 | AUTOMATIC DEVICE FOR THE SYNTHESIS OF PEPTIDE-BASED RADIOACTIVE DRUGS FOR DIAGNOSTIC AND/OR THERAPEUTIC USE - Device for the synthesis of peptide-based radioactive drugs, for diagnostic and/or therapeutic use, includes: a frame; a closing case for the frame; a first disposable main module; a second disposable module, slidingly associated with the first module; a third disposable test-tube holder module, reversibly fixable to the frame ( | 2014-02-20 |
20140050636 | TEST REAGENT CONTAINER - A test reagent container including a discharge port, formed by depressing a projecting part formed on a container bottom part, through which content can be easily and reliably discharged. The test reagent container includes: a bottom part; a peripheral wall raised approximately perpendicularly from a periphery of the bottom part; and a storage part defined by the bottom part and peripheral wall. A projecting part is formed on the bottom part in a projecting manner toward outside the container. A proximal end of the projecting part is formed in a bendable manner relative to the bottom part, and an easily breakable part is formed on a periphery of the projecting part except for the proximal end of the projecting part. The easily breakable part is broken when the projecting part is depressed from outside the container to be pushed into the inside of the container to form a discharge port. | 2014-02-20 |
20140050637 | PUNCHING DEVICE WITH GRIPPER UNIT - The invention relates to a punching device for processing samples, in particular dried samples, applied to a sample card, preferably liquids containing DNA, such as blood, saliva and the like, comprising at least one punching means with a punch and a lower die, wherein the punch is movable between a resting position at a distance from the lower die and a punching position closer to the lower die. The punching means has a receiving opening, into which a sample card from a sample card container can be introduced by means of a movable gripping unit ( | 2014-02-20 |
20140050638 | Microwell Covers for Microplates - Covers for microwells, the covers comprising open portions to allow a pipette access to one or more wells and impermeable portions which prevent the liquids from getting into wells shielded by the impermeable portion. The open portions and impermeable portions are preferably arranged and sized to align with alternating rows of wells in a particular microplate. Preferred covers are movably positioned on the microplate. Automated dispensing apparatus for use with microplates and microwell covers comprises a programmable controller, and suitable interfaces which allow the apparatus to be programmed, and which control a dispensing head such that pipettes are moved in the desired manner in order to take advantage of the protective features of the microwell covers. The apparatus also preferably comprises at least one transfer mechanism for moving a cover relative to a microplate at a dispensing station. | 2014-02-20 |
20140050639 | SEPARATION METHOD FOR POTASSIUM FROM AQUEOUS KOH SOLUTIONS - The process described herein demonstrates a more efficient and effective way to remove certain chemicals from industrial waste water. Specifically, the invention set forth demonstrates a method comprised of at least two steps in which up to 96% of potassium can be removed from an aqueous solution comprising potassium hydroxide. | 2014-02-20 |
20140050640 | MERCURY SORBENTS - Disclosed herein are methods for the on-site manufacture of aqueous-based mercury sorbent compositions prepared using a process water. The sorbent compositions may be aqueous-based materials manufactured from a silica containing precursor, a metal species, and a sulfur-based species, in the presence of a process waters, such as a process water from a coal-fired power plant. | 2014-02-20 |
20140050641 | MERCURY SORBENTS - Disclosed are methods for the on-site manufacture of aqueous-based mercury sorbent compositions prepared using a process water. The sorbent compositions may be aqueous-based materials manufactured from a silica containing precursor, a metal species, and a sulfur-based species, in the presence of a process waters, such as a process water from a coal-fired power plant. | 2014-02-20 |
20140050642 | METHOD AND DEVICE FOR MONITORING A REDUCING AGENT SOLUTION COMPOSITION IN THE EXHAUST GAS SYSTEM OF AN INTERNAL COMBUSTION ENGINE - A method for monitoring a reducing agent solution composition in an exhaust gas system of an internal combustion engine with metered injection of the reducing agent solution upstream of an SCR catalytic converter comprises metering injection of the reducing agent solution into the exhaust gas stream, determining a measured variable of a change in water content in the exhaust gas stream in response to the injected reducing agent solution, and determining at least one indicator value of a composition of the reducing agent solution at least based on the determined measured variable. In this way, deviations from the standard composition may be taken into account during metering or be displayed as an error. | 2014-02-20 |
20140050643 | Flur-Gas purification and reclamation system and method thereof - A flue-gas purification system includes a flue-gas cycling system, a reactor, and an absorbent adding system having at least a catalytic absorbent, wherein the catalytic absorbent is being gasified for reacting with the flue-gas in the reactor in a homogenous gas-gas phase reacting manner. Therefore, the purification system has fast reaction rate between the pollutants of the flue-gas and the catalytic absorbent, which is preferably ammonia, to efficiently remove pollutants, so as to effectively purify the flue-gas. | 2014-02-20 |
20140050644 | CHARGE-INDUCED SELECTIVE REDUCTION OF NITROGEN - A selective catalytic reduction system (SCR) or selective non-catalytic reduction (SNCR) system include a reagent charging apparatus configured to apply one or more electrical charges to a NOx reducing reagent. The electrical charges enhance mixing of the reagent with fluids carrying NOx and/or enhance reactivity of the reagent with NOx. | 2014-02-20 |
20140050645 | WET SCRUBBER FOR REMOVING SULFUR DIOXIDE FROM A PROCESS GAS - A wet scrubber ( | 2014-02-20 |
20140050646 | SUPERHARD BORON OXYNITRIDE AND METHOD FOR PRODUCING THE SAME | 2014-02-20 |
20140050647 | APPARATUS AND METHOD FOR THE CONDENSED PHASE PRODUCTION OF TRISILYLAMINE - The present invention is directed to a condensed phase batch process for synthesis of trisilylamine (TSA). An improved synthesis process that incorporates a solvent to help promote a condensed-phase reaction between ammonia gas (or liquid) and liquified monochlorosilane (MCS) in good yields is described. This process facilitates the removal of the byproduct waste with little to no reactor down time, substantial reduction of down-stream solids contamination and high-purity product from first-pass distillation. | 2014-02-20 |
20140050648 | PREPARATION OF CHLOROSILANES FROM VERY FINELY DIVIDED ULTRA-PURE SILICON - The invention provides a process and apparatus for preparing chlorosilane from the reaction of very finely divided ultra-pure silicon with hydrogen chloride, the very finely divided ultra-pure silicon being fed into a solid bed of metallurgical silicon, the feed line for ultra-pure silicon and the fixed bed having a certain minimum temperature. | 2014-02-20 |
20140050649 | Methods Apparatus for Manufacturing Geometric Multi-Crystalline Cast Materials - Methods are provided for casting one or more of a semi-conductor, an oxide, and an intermetallic material. With such methods, a cast body of a geometrically ordered multi-crystalline form of the one or more of a semiconductor, an oxide, and an intermetallic material may be formed that is free or substantially free of radially-distributed impurities and defects and having at least two dimensions that are each at least about 10 cm. | 2014-02-20 |
20140050650 | SUPERHARD CARBON NITRIDE AND METHOD FOR PRODUCING THE SAME | 2014-02-20 |
20140050651 | System and process for trapping sulfur dioxide and carbon dioxide by ammonia absorption at atmospheric pressure - A system and a process for capture and absorption of sulfur dioxide and carbon dioxide by an ammonia method at normal pressure are disclosed. The system has a dilute ammonia water supply device connected with sulfur dioxide and carbon dioxide absorption devices; an induced draft fan is connected with a heat exchanger connected with the sulfur dioxide absorption device; a sulfur dioxide absorption tower is connected with a carbon dioxide absorption tower; cooling devices in the sulfur dioxide and carbon dioxide absorption towers share a cooling water inlet and outlet pipe; the sulfur dioxide and carbon dioxide absorption devices respectively restore ammonia concentration to original ammonia water concentration by supplementing concentrated ammonia water; the sulfur dioxide and carbon dioxide absorption devices respectively pump solutions into the heat exchangers, then the solutions enter crystallization tanks; solid-liquid separation is performed through centrifuges, and the liquid continues to circulate in the system. | 2014-02-20 |
20140050652 | GRAPHENE AND ITS GROWTH - The present invention provides graphene nuclei including monolayer single-crystalline graphene nuclei and a method of growing from them two-dimensional graphene dendrites, with aspect ratio of the main branches increasing with growth time, on catalytic metal surface using thermal chemical vapor deposition. By controlling the supply rates of the carbon etching gas and the carbon deposition species, it results in graphene branches being merged to form a two-dimensional monolayer single-crystalline graphene plate and further allows multiple graphene plates to merge and form a large-area continuous monolayer graphene plate. | 2014-02-20 |
20140050653 | Process for Producing Fluorine-Containing Combined Salt - Disclosed is a process for producing a fluorine-containing complex salt, characterized by that, on a reaction mother liquor containing a plurality of cation species and a fluoroanion in a state that they have been dissolved in a solvent, a trigger for accelerating decomposition of the fluoroanion is allowed to act, thereby precipitating a complex salt containing a plurality of cation species and fluorine, as a solid, from the reaction mother liquor. According to this process, it is possible to produce a monodispersed fluorine-containing complex salt with uniform particle size and shape. | 2014-02-20 |
20140050654 | CERIA-ZIRCONIA-MIXED OXIDE PARTICLES AND PROCESS FOR THEIR PRODUCTION BY PYROLYSIS - Described is a process for the production of mixed oxide particles. The process comprises providing a mixture comprising a solvent, one or more precursor compounds of ceria, one or more precursor compounds of zirconia, and one or more precursor compounds of one or more rare earth oxides other than ceria and/or one or more precursor compounds of yttria; forming an aerosol of the mixture; and pyrolyzing the aerosol of to obtain mixed oxide particles. The content of the rare earth oxides other than ceria and/or of yttria in the mixed oxide particles is comprised in the range of from 0.1 to 4.9 wt.-% based on the total weight of the rare earth oxides, yttria, and zirconia contained in the mixed oxide particles. Also describes are mixed oxide particles obtained from flame spray pyrolysis and to their use as an oxygen storage component, a catalyst, and/or as a catalyst support. | 2014-02-20 |
20140050655 | SYNTHESIS OF METAL OXIDE-BASED THERMOELECTRIC MATERIALS FOR HIGH TEMPERATURE APPLICATIONS - Nanowire synthesis and one dimensional nanowire synthesis of titanates and cobaltates. Exemplary titanates and cobaltates that are fabricated and discussed include, without limitation, strontium titanate (SrTiO | 2014-02-20 |
20140050656 | SURFACE-TREATMENT METHOD OF CATHODE ACTIVE MATERIAL AND CATHODE ACTIVE MATERIAL FORMED THEREFROM - The present invention provides a method for treating the particle surface of a cathode active material for a lithium secondary battery, the method comprising (a) preparing a cathode active material having a lithium compound; (b) generating a plasma from a gas comprising at least one of a fluorine-containing gas and a phosphorus-containing gas as a part of a reactive gas; and (c) removing lithium impurities present on the particle surface of the cathode active material with the plasma. In accordance with the present invention, the amount of the lithium impurities present on the particle surface of the cathode active material can be reduced to suppress a side reaction of the lithium impurities and an electrolyte. | 2014-02-20 |
20140050657 | PROCESS FOR MANUFACTURING LITHIUM TITANIUM OXIDES - Provided is a process for manufacturing, at a low cost and efficiently, lithium titanium oxides which are useful for electricity storage devices. A desired lithium titanium oxide can be obtained by heating at least both (1) a titanium compound and (2) a lithium compound that has a volume-mean particle diameter of | 2014-02-20 |
20140050658 | SOLID/HEAT-TRANSFER GAS REACTOR COMPRISING GAS DIFFUSERS WITH REDUCED RISKS OF BLOCKING - A module for a solid/heat-transfer gas reactor, including a plurality of diffusers each including a top portion supporting the solid reagent, and a portion for diffusing reactive/heat-transfer gas, situated under the top portion. | 2014-02-20 |
20140050659 | METHODS OF CONTROLLING POLYMORPHISM IN ORGANIC-FREE SYNTHESIS OF NA-ZEOLITES AND ZEOLITE CRYSTALS FORMED THEREFROM - Methods of controlling crystal polymorphism in organic-free synthesis of Na-Zeolites and the zeolite crystals formed using those methods are provided. The methods disclosed herein create certain types of zeolite crystals more efficiently than other previously known methods. The methods also create certain types of zeolite crystals in a form and concentration not previously disclosed. The methods disclosed herein generally comprise using solutions with varying ratios of silicon (Si), aluminum (Al), hydroxide (OH), and water. Some implementations of the invention disclosed include efficient methods of producing nearly pure cancrinite (CAN), methods of obtaining sodalite in solutions with a high Si/Al ratio, and a method of forming thin, platelet-like ANA crystals with a width of less than about 1 μm and a length of at least about 3 μm. | 2014-02-20 |
20140050660 | T-Cell Redirecting Bispecific Antibodies for Treatment of Disease - The present invention concerns compositions and methods of use of T-cell redirecting complexes, with at least one binding site for a T-cell antigen and at least one binding site for an antigen on a diseased cell or pathogen. Preferably, the complex is a DNL™ complex. More preferably, the complex comprises a bispecific antibody (bsAb). Most preferably, the bsAb is an anti-CD3×anti-CD19 bispecific antibody, although antibodies against other T-cell antigens and/or disease-associated antigens may be used. The complex is capable of targeting effector T cells to induce T-cell-mediated cytotoxicity of cells associated with a disease, such as cancer, autoimmune disease or infectious disease. The cytotoxic immune response is enhanced by co-administration of interferon-based agents that comprise interferon-α, interferon-β, interferon-λ1, interferon-λ2 or interferon-λ3. | 2014-02-20 |
20140050661 | NOVEL ANTI-CXCR4 ANTIBODIES AND THEIR USE FOR THE TREATMENT OF CANCER - The present invention relates to a novel isolated antibody, or the derived compounds or functional fragments of same, capable of binding to CXCR4 but also of inducing conformational changed of the CXCR4 homodimers and/or heterodimers. | 2014-02-20 |
20140050662 | PROSTATE SPECIFIC ANTIGEN AGENTS AND METHODS OF USING SAME FOR PROSTATE CANCER IMAGING - The invention provides a family of agents that target the prostate specific antigen, which can be used as imaging agents or therapeutic agents. The agents can be used to image prostate cancer as well as other physiological processes in a subject. | 2014-02-20 |
20140050663 | Labeled A4B2 Ligands and Methods Therefor - Contemplated compositions and methods are employed to bind in vitro and in vivo to an α4β2 nicotinic acetylcholine receptor in a highly selective manner. Where such compounds are labeled, compositions and methods employing such compounds can be used for PET and SPECT analysis. Alternatively, and/or additionally contemplated compounds can be used as antagonists, partial agonists or agonists in the treatment of diseases or conditions associated with α4β2 dysfunction. | 2014-02-20 |
20140050664 | SOY, LENTIL OR EXTRACT STABILIZED, BIOCOMPATIBLE GOLD NANOPARTICLES - The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from soy or lentil plant material or a reactive extract thereof of the plant material. The gold nanoparticles of the invention can be fabricated with an environmentally friendly method for making biocompatible stabilized gold nanoparticles. The nanoparticles can be introduced in vivo to conduct enhanced imaging. The nanoparticles can also be introduced in vivo to conduct therapy. | 2014-02-20 |
20140050665 | METHOD FOR THE TREATMENT OR PROPHYLAXIS OF LYMPHANGIOLEIOMYOMATOSIS (LAM) AND ANIMAL MODEL FOR USE IN LAM RESEARCH - Treatment of lymphangioleiomyomatosis with the MEK1/2 inhibitor CI-1040 delayed the development of primary tumors and blocked the estrogen-induced lung metastases in treated animals. Such treatment also reduced the number of circulating ELT3 cells and decreased their lung colonization after intravenous injection. | 2014-02-20 |
20140050666 | SCAVENGER RECEPTOR UPTAKE FOR FABRY DISEASE ENZYME REPLACEMENT THERAPY - The present invention relates to a composition comprising a lysosomal enzyme conjugated to a negatively charged scavenger receptor ligand. In some embodiments, the lysosomal enzyme is conjugated to the scavenger receptor ligand by way of a linker. The present invention also relates to a composition comprising lysosomal enzyme encapsulated by a liposome, said liposome externally comprising a negatively charged scavenger receptor ligand. The invention further encompasses a method of treating a lysosomal storage disease with the compositions listed above. The invention further encompasses a method of treating a lysosomal storage disease with an acylated, acetylated, or aconitylated lysosomal enzyme. | 2014-02-20 |
20140050667 | RENAL FUNCTION ANALYSIS METHOD AND APPARATUS - A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule. | 2014-02-20 |
20140050668 | VISUALIZATION OF LIPID METABOLISM - The present invention relates to the field of in vivo determination of enzyme activity. It also allows visualization of organisms, organs, tissues and cells. In particular, the present invention provides a method of in vivo visualization and a composition suitable for in vivo determination and/or visualization of enzyme activity by methods such as Magnetic Resonance Imaging, also called Magnetic Resonance Tomography (MRI or MRT), or Magnetic Particle Imaging (MPI). In particular, the activity of the enzyme lipoprotein lipase affects the signals received and allows conclusions on the lipid metabolism of an organism, an organ system, an organ, a tissue and a cell of interest, This method can be employed, e.g., for diagnosis of cardiac disorders, of tumor prognosis and of disorders of the lipid metabolism. The composition used comprises superparamagnetic iron oxide nanocrystals (SPIO) incorporated in the core of lipid micelles designated nanosomes. | 2014-02-20 |
20140050669 | USE OF RADIOGRAPHIC CONTRAST AGENTS FOR DETECTING DENTAL CARIES - The present invention provides methods of imaging dental tissue. More particularly, the invention relates to a method of imaging dental caries by administering a topical intra-oral composition that provides enhanced radiographic imaging. | 2014-02-20 |
20140050670 | MULTIFUNCTIONAL NANOPARTICLES - The invention provides a nanoparticle for delivery of therapeutic agents, comprising a polymeric nanosphere and one or more detection agents, said detection agents for use in detecting the location of the nanoparticle. The invention further provides a transfection agent comprising an aforementioned nanoparticle. | 2014-02-20 |
20140050671 | THERANOSTIC NANOPARTICLE AND METHODS FOR MAKING AND USING THE NANOPARTICLE - Nanoparticle having a poly(beta-amino ester) coating. The poly(beta-amino ester) coating includes one or more therapeutic agents that can be delivered by the particle and one or more anchoring groups that couple the polymer to the nanoparticle's core surface. In certain embodiments, the poly(beta-amino ester) includes one or more polyalkylene oxide groups. The poly(beta-amino ester) can further include a targeting agent to target the nanoparticle to a site of interest and a diagnostic agent that allows for imaging of the particle. Methods for making and using the nanoparticles are also provided. | 2014-02-20 |
20140050672 | EPIDERMAL COOLING - In one aspect, an epidermal coolant dispensable by an aerosol container includes a phase change material that changes phase between about 28-degrees and 40-degrees Celsius. The coolant also includes a solvent in which the phase change material is dissolved and a surfactant. The coolant may further include a propellant to express the product from the aerosol container. In another aspect, an epidermal coolant includes a porous material and a phase change material retained in the porous material. The phase change material has a melting point between about 0-degrees Celsius and about 65-degrees Celsius and is retained in the porous material when the phase change material is in either the solid or liquid phase. | 2014-02-20 |
20140050673 | Oil-Based Foamable Carriers And Formulations - A waterless foamable carrier and pharmaceutical composition which is suitable for external and internal administration is disclosed. The composition is single phase and includes at least one liquid oil; and a glyceride. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described. | 2014-02-20 |
20140050674 | Method for Improving Penetration or Long Term Adhesion of Compositions to Dental Tissues and Compositions Usable in Said Method - This invention concerns a method of improving penetration of compositions to dentin, enamel, dental pulp or cement and dental compositions for restoration or decoration of teeth, for use in pulp medication comprising, for root canal disinfection and/or obturation and for desensitizing. This invention also concerns uses of DMSO for improving the bond strength of dental composition and in preparing dental compositions. Further the invention concerns a new method of treating teeth so that penetration of components is increased. | 2014-02-20 |
20140050675 | ANTIOXIDANT COMPOSITIONS FOR SOFT ORAL TISSUE AND METHODS OF FORMULATION AND USE THEREOF - One embodiment of the invention is directed to an oral antioxidant composition including between 0.0001% and 5.0% w/w antioxidant, wherein the antioxidant includes cinnamic acid derivative, tetrahydrocurcuminoids, or phloretin and an orally pharmaceutically acceptable carrier. The composition may have a pH of at least 5.0. According to still further embodiments, the composition may also include between 0.0001% and 5.0% w/w of one or two more additional antioxidants that include cinnamic acid derivative, tetrahydrcurcuminoids, phloretin, or a stilbene derivative. In more particular embodiments, the cinnamic acid derivative may include trans-ferulic acid, the tetrahydrocurcuminoids may include tetrahydrcurcuminoids CG™, or the stilbene derivative may include resveratrol. Other embodiments may relate to methods of treating or preventing an oral disease by applying topically an antioxidant composition as described above. | 2014-02-20 |
20140050676 | Method for Treating Skin with Retinoids and Retinoid Boosters - A skin care product comprising from about 0.001% to about 10% of a retinoid, in combination with 0.0001% to about 50% of a combination of retinoid boosters. | 2014-02-20 |
20140050677 | Personal care and medicinal products incorporating bound organosulfur groups - Personal care products useful for the maintenance of personal appearance and good health and minor treatments that do not require professional health care, as well as products that provide a combination of anti-oxidant, anti-inflammatory, antimicrobial, and anti-aging properties and are suitable for use without a prescription. The products utilize biomembrane permeable organosulfur compounds that can redox cycle between thiol, disulfide, and thiosulfinate forms in response to antioxidants and oxidants that are inside and outside of cells. Example products include an antioxidant skin lotion with anti-inflammatory, antimicrobial, anti-arsenicosis, anti-aging, and deodorant properties. | 2014-02-20 |
20140050678 | USE, AS ANTIDANDRUFF AGENT, OF (ETHOXYHYDROXYPHENYL) ALKYL KETONE OR ETHOXYHYDROXYALKYLPHENOL COMPOUNDS - The present invention relates to the use, as an antidandruff agent, of a compound of formula: | 2014-02-20 |
20140050679 | COSMETIC COMPOSITION COMPRISING A CUCURBIC ACID COMPOUND AND A BLEND OF SULFONIC AND ACRYLIC POLYMERS - The invention relates to a cosmetic composition comprising, in a physiologically acceptable aqueous medium, a cucurbic acid compound of formula (I) | 2014-02-20 |
20140050680 | DAPSONE TO TREAT ROSACEA - The methods described herein provide treatment of rosacea using topical formulations of dapsone. The methods also provide treatment of rosacea with topical dapsone in combination with other active agents, including metronidazole. The methods avoid negative hematologic side effects, including hemolysis and hemolytic anemia, that are associated with oral administration of dapsone. | 2014-02-20 |
20140050681 | METHOD OF PHOTOSTABILIZING UV ABSORBERS, PARTICULARLY DIBENZYOLMETHANE DERIVATIVES, E.G., AVOBENZONE, WITH CYANO-CONTAINING FUSED TRICYCLIC COMPOUNDS - A photostabilized photoactive composition comprising a mixture of a photoactive compound that develops a singlet excited state, or fluoresces when subjected to UV radiation and an effective amount of an excited state quencher comprising a cyano-containing fused tricyclic compound of formula (I): | 2014-02-20 |
20140050682 | REMOVABLE COLOR LAYER FOR ARTIFICIAL NAIL COATINGS AND METHODS THEREFOR - The present disclosure relates to a nail coating system comprising a basecoat, a color layer, and a topcoat. The system of the present disclosure may be applied to natural and/or pre-existing artificial nail coatings. The present disclosure relates generally to compositions for natural and artificial nail coatings, and particularly, but not by way of limitation, to polymerizable compositions and color layers polymerized therefrom. The disclosure further relates to methods of making a polymerized color layer. | 2014-02-20 |
20140050683 | HETEROCYCLIC RESORCINOL DERIVATIVES, PREPARATION OF SAME AND COSMETIC USES THEREOF - The invention relates to a compound of general formula (I) | 2014-02-20 |
20140050684 | COSMETIC PROCESS FOR TREATING HUMAN BODY ODOR USING A 4-(3-ETHOXY-4-HYDROXYPHENYL)ALKYL KETONE OR 2-ETHOXY-4-HYDROXYALKYLPHENOL COMPOUND - The present invention relates to a cosmetic process for treating human body odor, in particular underarm odor, which consists in applying to human keratin materials a composition containing, in a cosmetically acceptable medium, at least one 4-(3-ethoxy-4-hydroxyphenyl)alkyl ketone or 2-ethoxy-4-hydroxyalkylphenol compound of formula (I) below: | 2014-02-20 |
20140050685 | EXISTING SHAMPOO/CONDITIONER COMPANY PRODUCT this time with 55% Water 45% Existing Company Shampoo/Conditioner Ingredient Solution - Existing Shampoo/Conditioner Company Product this time with 55% Water 45% Existing Company Shampoo Ingredient Solution is disclosed. It takes less time to shampoo and rinse the hair. There is a better chance of the shampoo to penetrate and be distributed through the hair evenly. | 2014-02-20 |
20140050686 | AGENT FOR KERATINOUS FIBERS, COMPRISING AT LEAST ONE ACRYLATE/GLYCERYL ACRYLATE COPOLYMER, AT LEAST ONE FILM-FORMING AND/OR SOLIDIFYING POLYMER AND AT LEAST ONE ESTER OIL - The present invention is an agent for treating keratinous fibers, particularly human hair, comprising: (a) at least one glyceryl acrylates/acrylates copolymer; (b) at least one film-forming and/or setting polymer; and (c) at least one ester oil. The agent may additionally comprise a polyol such as glycerin. The agent is best suited for temporarily deforming hairs into a desired shape or style and for the general caring of hair. | 2014-02-20 |
20140050687 | BETAINE ESTERS AND PROCESS FOR MAKING AND USING - A variety of betaine esters, including dialkylaminoalkyl cocoate betaines and dialkylaminoalkyl hydrogenated cocoate betaines are disclosed. These betaines can be advantageously prepared in high yield and purity by a three-step transiterification chemoenzymatic process or a two-step direct esterficiation chemoenzymatic process. These betaine esters have excellent surfactant properties. | 2014-02-20 |
20140050688 | Hair Care Compositions - Compositions and methods are disclosed for imparting a long-wearing shine to keratin fibers, including hair. The compositions comprise an aminosilicone polymer having a viscosity from about 800 to about 1,600 mm | 2014-02-20 |
20140050689 | TISSUE GRAFTED WITH A BIODEGRADABLE POLYMER - Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto compounds are described. Also described are the methods and compositions wherein the tissue is fixed using biodegradable crosslinkers. Methods and compositions for making radio-opaque tissue are also described. Methods and compositions to obtain a degradable implantable tissue-synthetic biodegradable polymer composite are also described. Compositions and methods of incorporating substantially water-insoluble bioactive compounds in the implantable tissue are also disclosed. The use of membrane-like implantable tissue to make an implantable drug delivery patch are also disclosed. Also described are the compositions and methods to obtain a coated implantable tissue. Medical applications implantable tissue such as heart valve bioprosthesis, vascular grafts, meniscus implant, drug delivery patch are also disclosed. | 2014-02-20 |
20140050690 | NANOPARTICLE CONTAINING PROSTAGLANDIN I 2 DERIVATIVE - There is provided a beraprost sodium-containing nanoparticle that contains beraprost sodium among other prostaglandin I | 2014-02-20 |
20140050691 | SYNTHESIS MODELS FOR ANTIMICROBIAL AGENTS VIA THE HALOGENATION OF ORGANIC/INORGANIC COMPOSITES - A method of forming a biocidal halogenated organic/inorganic composite material may include providing at least one inorganic precursor, providing at least one organic agent, precipitating an organic/inorganic composite material by contacting the at least one inorganic precursor with the at least one organic agent, and halogenating the organic/inorganic composite material by contacting the organic/inorganic composite material with a halogen. Also, a halogenated organic/inorganic composite material may include an inorganic composition comprising a metal oxide and a halogenated organic composition. The inorganic composition and the halogenated organic composition are dispersed throughout the composite material. | 2014-02-20 |
20140050692 | POLYESTERS AND METHODS OF USE THEREOF - The invention provides polymers and methods for the treatment of pain and inflammation. | 2014-02-20 |
20140050693 | BIOLOGICAL ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY - Increased in vivo and/or in vitro stability is imparted to a biologically active protein by fusing to an amino acid sequence consisting of at least about 100 amino acid residues, which consist essentially of Alanine, Serine and Proline, which form a random coil conformation. Specific examples are described. Also described are related nucleic acids, vectors and cells encoding such amino acids; compositions of biologically active proteins fused to a random coil domain, and methods of making and using the compounds and compositions of the invention. | 2014-02-20 |
20140050694 | Method of Treating Transplant Rejection and Autoimmune Diseases - A method of treating autoimmune diseases and transplant rejection, comprising the step of treating the autoimmune or transplant patient with an effective amount of SU-5416 is disclosed. | 2014-02-20 |
20140050695 | Hepatitis C Virus Inhibitors - The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection. | 2014-02-20 |
20140050696 | NOVEL BISAMINOQUINOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS PREPARED THEREFROM AND THEIR USE - The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and/or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention. Methods of treating disease states and/or conditions in which inhibition of autophagy plays a favorable treatment role including rheumatoid arthritis, malaria, antiphospholipid antibody syndrome, lupus, chronic urticaria and Sjogren's disease, with compounds according to the present invention represent additional aspects of the invention. | 2014-02-20 |
20140050697 | ANALYSIS OF HCV GENOTYPES - A method for predicting response of a patient infected with HCV-1a to interferon treatment. | 2014-02-20 |
20140050698 | RECOMBINANT SUPER-COMPOUND INTERFERON AND USES THEREOF - This invention provides a method for treating tumors in a subject, comprising administering to the subject an effective amount of a recombinant interferon, wherein the interferon has the amino acid sequence of SEQ ID NO:2 and is encoded by the nucleotide sequence SEQ ID NO:1, wherein the tumors are selected from the group consisting of skin cancer, basal cell carcinoma, liver cancer, thyroid cancer, rhinopharyngeal cancer, solid carcinoma, prostate cancer, esophageal cancer, pancreatic cancer, superficial bladder cancer, hemangioma, epidermoid carcinoma, cervical cancer, glioma, leucocythemia, acute leucocythemia, chronic leucocythemia, lymphadenoma, and polycythemia vera. | 2014-02-20 |
20140050699 | HETEROCYCLIC INHIBITORS OF GLUTAMINASE - The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel heterocyclic compounds of the invention. | 2014-02-20 |
20140050700 | EX-VIVO TREATMENT OF PERIPHERAL BLOOD LEUKOCYTES WITH IFN-Lambda - The present invention provides a method of treating Th2-associated diseases and disorders by modulating the expression or secretion of IL-4, IL-5 and IL-13 using interferon lambda (IFN-λ). For Th2-associated diseases and disorders, cells of a patient having a Th2-associated disease or disorder are treated ex vivo, with IFN-λ and returned to the patient. The present invention also provides a method of ex vivo treatment, in conjunction with co-administration of IFN-λ | 2014-02-20 |
20140050701 | CAPSID-MODIFIED rAAV VECTOR COMPOSITIONS HAVING IMPROVED TRANSDUCTION EFFICIENCIES, AND METHODS OF USE - Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using novel capsid-protein-mutated rAAV vector constructs in a variety of diagnostic and therapeutic applications including, inter alia, as delivery agents for diagnosis, treatment, or amelioration of one or more symptoms of disease or abnormal conditions via in situ and/or ex vivo mammalian gene therapy methods. Also disclosed are large-scale production methods for capsid-modified rAAV expression vectors, viral particles, and infectious virions having improved transduction efficiencies over those of the corresponding, un-modified, rAAV vectors, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications. | 2014-02-20 |
20140050702 | Compositions and Methods for Reducing Blood Alcohol Content - Disclosed are compositions and methods for reducing blood alcohol content following alcohol consumption. The inventive compositions and methods rapidly reduce blood alcohol content and alleviate symptoms of intoxication in a subject having an elevated blood alcohol content due to alcohol consumption. | 2014-02-20 |
20140050703 | EQUOL-PRODUCING LACTIC ACID BACTERIA-CONTAINING COMPOSITION - An equol-producing lactic acid bacteria-containing composition comprises, as an essential component thereof, a lactic acid bacterial strain belonging to the genus | 2014-02-20 |
20140050704 | STEM CELL CULTURE METHOD - Methods for culturing pluripotent stem cells on fiber scaffolds are provided which result in the expansion of the number of stem cells without loss of pluripotency. Cells obtained by such methods, implants containing such cells and medical methods using such cells are also disclosed. | 2014-02-20 |
20140050706 | Compositions Comprising Human Embryonic Stem Cells and Their Derivatives, Methods of Use, and Methods of Preparation - The present invention relates to a pharmaceutical composition comprising of preparations of human embryonic stem (hES) cells and their derivatives and methods for their transplantation into the human body, wherein transplantation results in the clinical reversal of symptoms, cure, stabilization or arrest of degeneration of a wide variety of presently incurable and terminal medical conditions, diseases and disorders. The invention further relates to novel processes of preparing novel stem cell lines which are free of animal products, feeder cells, growth factors, leukaemia inhibitory factor, supplementary mineral combinations, amino acid supplements, vitamin supplements, fibroblast growth factor, membrane associated steel factor, soluble steel factor and conditioned media. This invention further relates to the isolation, culture, maintenance, expansion, differentiation, storage, and preservation of such stem cells. | 2014-02-20 |
20140050707 | MIR-150 FOR THE TREATMENT OF BLOOD DISORDERS - The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor cells respectively. | 2014-02-20 |
20140050708 | Compositions and Methods for Treating Cancer - The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer. | 2014-02-20 |
20140050709 | REVERSING THE EFFECTS OF THE TUMOR MICROENVIRONMENT USING CHIMERIC CYTOKINE RECEPTORS - Disclosed are compositions and methods related to rendering ineffective Th1 T cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. Tumor-specific T cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a Th1 immunostimulatory/activating signal. The T cells employ a chimeric antigen receptor having exodomains for IL10, IL13 and/or IL4 fused with the signal transducing endodomains for IL2 and/or IL7. | 2014-02-20 |
20140050710 | METHODS FOR PREPARING ACCESSORY CELLS AND USES THEREOF FOR PREPARING ACTIVATED NK CELLS - The present invention relates to a method for preparing accessory cells, said accessory cells may themselves be used for preparing activated NK cells that may be used in various therapeutic protocols (e.g. cancer treatment). More particularly, the present invention relates to a method for preparing an accessory cell comprising the steps consisting of i) providing a cell and ii) inhibiting in said cell the expression of a gene encoding for a Killer-Cell Immunoglobulin-like Receptor(s) (KIR) ligand. | 2014-02-20 |
20140050711 | PRODUCTION OF RED BLOOD CELLS AND PLATELETS FROM STEM CELLS - This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a stem cell into a MEP in culture in the presence of an aryl hydrocarbon receptor (AhR) agonist. In some embodiments the stem cell is a pluripotent stem cell. In some embodiments the MEP co-expresses CD41 and CD235. In some embodiments the number of MEPs produced in the culture increases exponentially. Methods of making a red blood cell (RBC) by culturing a MEP in the presence of an AhR agonist are also provided. Methods of making a megakaryocyte and/or a platelet, comprising culturing a MEP in the presence of an AhR modulator are also provided. In some embodiments the AhR modulator is an AhR antagonist. This disclosure also provides compositions comprising at least 1 million MEPs per ml and compositions in which at least 50% of the cells are MEPs. | 2014-02-20 |
20140050712 | DISORDERS IMPLICATING PUFA OXIDATION - Some aspects of the invention provide for a method of treating hepatic disorders, lipidemias and cardiac-related risk factors using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds. | 2014-02-20 |
20140050713 | CHIMERIC ANTIBACTERIAL POLYPEPTIDES - Provided herein are antibacterial compositions and methods of making and using the compositions. | 2014-02-20 |
20140050714 | USE OF HSP70 AS A REGULATOR OF ENZYMATIC ACTIVITY - The present invention concerns a method for modulating the enzymatic activity of an enzyme, wherein said enzyme interacts with BMP, said method comprising the step of administering or inducing Hsp70, or a functional fragment or variant thereof, in a form suitable for allowing interaction between BMP and Hsp70, or said functional fragment or variant thereof, and thereby modulating the enzymatic activity of an enzyme interacting with BMP. | 2014-02-20 |