05th week of 2013 patent applcation highlights part 49 |
Patent application number | Title | Published |
20130029822 | APPARATUS AND METHOD FOR INSERTION OF CAPSULES INTO FILTER TOWS - An apparatus for insertion of capsules into cigarette filter tows is disclosed. The apparatus may include a tow processing unit, a capsule insertion unit and a filter rod making unit. The capsule insertion unit may include a hopper, a belt, an inlet pipe, a capsule feeder wheel and a capsule insertion wheel. | 2013-01-31 |
20130029823 | Paperboard Cartons With Laminated Reinforcing Ribbons And Transitioned Scores And Method Of Making Same - A method of making reinforced paperboard cartons comprises the steps of advancing a web of paperboard along a path and progressively laminating at least one ribbon of reinforcing material to the advancing web of paperboard. The ribbon of reinforcing material, which also may be paperboard, has a width less than the width of the web of paperboard and is applied with adhesive at a selected location across the width of the web. The web and its laminated ribbon are cut into sheets of a predetermined size and the sheets are die-cut and scored with fold lines to form carton blanks. The fold lines may transition from non-reinforced to reinforced portions of the blank and a special transition zone is contemplated to accommodate the transition. The carton blanks are subsequently formed into cartons for receiving articles, the laminated reinforcing material providing reinforcement in selected portions of the cartons. Multiple ribbons and multiple layers of ribbons may be laminated to the web in respective selected locations to provide reinforcement in more than one portion of the cartons. Reinforcing ribbons may be deformed or altered to exhibit, for instance, corrugations or perforations prior to being adhered to the base sheet. Reinforced cartons and carton blanks made by the method also are provided. | 2013-01-31 |
20130029824 | TIER CAP FORMING APPARATUS - A pallet tier cap forming apparatus is provided for forming a horizontal planar paperboard blank into a pallet tier cap. The blank includes a generally rectangular center panel having four edges, and four flaps connected by fold lines with the center panel edges, respectively. A blank transport device initially displaces the blank laterally in a first diagonal direction for simultaneous engagement with a first orthogonally arranged pair of drag walls, and vertically upwardly, thereby to break downwardly about associated fold lines a first pair of adjacent flaps of the blank. The blank is further displaced laterally in the first direction, thereby to reversely fold back the first pair of flaps about the associated wall junctions toward an acute angle relative to the blank center panel. The blank is then displaced in the opposite diagonal direction, and the forming steps are repeated to fold downwardly simultaneously a second pair of flaps. | 2013-01-31 |
20130029825 | Apparatus and Method for Producing Printed Articles - A sheet processing apparatus that is adapted to receive or include at least one sheet input roll, and a substantially continuous sheet of material fed therefrom. The apparatus includes sheet processing equipment for processing the sheet after it has been unrolled off the input roll and at least one digital printer adapted to print a surface of the substantially continuous sheet within the sheet processing apparatus. | 2013-01-31 |
20130029826 | Multi-Web Multi-Collect Folder and Method - A folder for a printing press is provided. The folder includes a first cutting cylinder for cutting a first web into a plurality of first sheets, a second cutting cylinder for cutting the second web into a plurality of second sheets and for holding a second sheet, a transfer cylinder receiving at least one first sheet and at least one second sheet at a transfer location and a storage cylinder storing at least one of the plurality of second sheets cut from the web, the second cutting cylinder capable of transferring second sheets to the storage cylinder. A printing press and methods are also provided. | 2013-01-31 |
20130029827 | FOLDING DEVICE, FOLDING SYSTEM, AND FOLDING METHOD FOR DISPOSABLE WORN ARTICLE - A device including: a main folding mechanism for folding a diaper body in two at the crotch portion by rotating first and second main pads having first and second holding surfaces, respectively; and a sub-folding mechanism for folding the flap by rotating a side pad having a sub-holding surface for holding the flap with respect to the first main pad, wherein; a cut-out is formed at a position corresponding to the attachment portion of the second main pad, wherein the cut-out does not allow the attachment portion to be held by the second main pad but instead expose the attachment portion; with the first and second holding surfaces being closed while opposing each other and with the main body folded in two, the cut-out allows the flap to be attached to the attachment portion; and the side pad rotates from a position where it is open while lying next to the first main pad in the girth direction to a position where the sub-holding surface is closed while opposing the first holding surface, fitting into the cut-out. | 2013-01-31 |
20130029828 | SYSTEM COMPRISING CENTRIFUGAL SEPARATOR AND METHOD FOR CONTROLLING SUCH A SYSTEM - The present invention relates to a system comprising a hermetic centrifugal separator where the separator comprises a rotor including a separation chamber, an inlet channel for a mixture of components to be separated, a first outlet channel for receiving at least one separated light component, and a second outlet channel for receiving at least one separated heavy component. | 2013-01-31 |
20130029829 | SYSTEMS AND METHODS FOR SEPARATING CONSTITUENTS OF BIOLOGIC LIQUID MIXTURES - Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other factors. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants. | 2013-01-31 |
20130029830 | GLASS SUBSTRATE FOR FLAT PANEL DISPLAY AND METHOD FOR MANUFACTURING SAME - Provided are: a glass substrate for p-Si TFT flat panel displays that is composed of a glass having high characteristic temperatures in the low-temperature viscosity range, typified by the strain point and glass transition point, having a small heat shrinkage rate, and being capable of avoiding the occurrence of the problem regarding the erosion/wear of a melting tank at the time of melting through direct electrical heating; and a method for manufacturing same. The present glass substrate is composed of a glass comprising 52-78 mass % of SiO | 2013-01-31 |
20130029831 | Homogeneous Process for the Hydrogenation of Carboxylic Acids and Derivatives Thereof - A homogenous process for the hydrogenation of the carboxylic acids and/or derivatives thereof in the presence of a catalyst comprising ruthenium, rhodium, iron, osmium or palladium, and an organic phosphine is described in which the hydrogenation is carried out in the presence of at least about 1% by weight water. A process for regenerating a catalyst comprising ruthenium, rhodium, iron, osmium or palladium and an organic phosphine is also described in which the regeneration is carried out in the presence of hydrogen and water. | 2013-01-31 |
20130029832 | STABILIZED AGGREGATES OF SMALL CRYSTALLITES OF ZEOLITE Y - This invention relates to stabilized aggregates of small primary crystallites of zeolite Y that are clustered into larger secondary particles. At least 80% of the secondary particles may comprise at least 5 primary crystallites. The size of the primary crystallites may be at most about 0.5 micron, or at most about 0.3 micron, and the size of the secondary particles may be at least about 0.8 micron, or at least about 1.0 μm. The silica to alumina ratio of the resulting stabilized aggregated Y zeolite may be 4:1 or more. | 2013-01-31 |
20130029833 | AGGREGATES OF SMALL CRYSTALLITES OF ZEOLITE Y - This invention relates to aggregates of small primary crystallites of zeolite Y that are clustered into larger secondary particles. At least 80% of the secondary particles may comprise at least 5 primary crystallites. The size of the primary crystallites may be at most about 0.5 micron, or at most about 0.3 micron, and the size of the secondary particles may be at least about 0.8 micron, or at least about 1.0 μm. The silica to alumina ratio of the resulting stabilized aggregated Y zeolite may be 4:1 or more. | 2013-01-31 |
20130029834 | Aluminoxane Catalyst Activators Derived From Dialkylalumium Cation Precursor Agents, Processes for Making Same, And Use Thereof In Catalysts And Polymerization Of Olefins - Compositions useful for activating catalysts for olefin polymerization, and methods for making same, are provided. Such compositions can be derived from at least: an organoaluminum compound, a carrier, an oxygen source, and, optionally, a Lewis base. | 2013-01-31 |
20130029835 | HYBRID CATALYSTS - There is provided a catalyst comprising metal nanoparticles supported on nanocrystalline cellulose and a homogeneous catalyst system comprising this catalyst colloidally suspended in a fluid. There is also provided a method of producing this catalyst and various uses thereof. | 2013-01-31 |
20130029836 | Composite Materials Formed With Anchored Nanostructures - A method of forming nano-structure composite materials that have a binder material and a nanostructure fiber material is described. A precursor material may be formed using a mixture of at least one metal powder and anchored nanostructure materials. The metal powder mixture may be (a) Ni powder and (b) NiAl powder. The anchored nanostructure materials may comprise (i) NiAl powder as a support material and (ii) carbon nanotubes attached to nanoparticles adjacent to a surface of the support material. The process of forming nano-structure composite materials typically involves sintering the mixture under vacuum in a die. When Ni and NiAl are used in the metal powder mixture Ni | 2013-01-31 |
20130029837 | Methods for Producing Metal-Containing Sulfated Activator-Supports - The present invention provides metal-containing sulfated activator-supports, and polymerization catalyst compositions employing these activator-supports. Methods for making these metal-containing sulfated activator-supports and for using such components in catalyst compositions for the polymerization of olefins are also provided. | 2013-01-31 |
20130029838 | EXHAUST GAS PURIFYING CATALYST - An exhaust gas purifying catalyst includes a substrate that defines an exhaust gas passage; a lower catalyst layer formed over the substrate, and an upper catalyst layer formed over the lower catalyst layer. The lower catalyst layer has a lower catalytic precious metal that contains at least one of Pt and Pd, and a lower-layer carrier that supports the lower catalytic precious metal. The upper catalyst layer has an upper catalytic precious metal that contains Rh, and an upper-layer carrier that supports the upper catalytic precious metal. The upper-layer carrier includes an inorganic mixed oxide that contains Ce, Zr, Al, Nd, and at least one element selected from the group consisting of rare earth elements other than Ce and alkaline earth elements. The Nd is unevenly distributed in covering layers that covers surfaces of interior regions within the inorganic mixed oxide. | 2013-01-31 |
20130029839 | CATALYSTS FOR THE OXIDATIVE REFORMING OF ALCOHOLS - The present invention relates to processes for the oxidative reforming of alcohols catalysed by metal catalysts on an oxide support that can be carried out at temperatures lower than 500° C., also showing a high conversion index, but maintaining a high selectivity as regards product distribution. Preferably, the starting material used in the processes is glycerol. | 2013-01-31 |
20130029840 | CERIA-ZIRCONIA BASE COMPOSITE OXIDE, METHOD FOR PRODUCING THE SAME, AND CATALYST FOR PURIFICATION OF EXHAUST GAS USING THE CERIA-ZIRCONIA BASE COMPOSITE OXIDE - A ceria-zirconia base composite oxide contains a composite oxide of ceria and zirconia. In the ceria-zirconia base composite oxide, a content ratio between cerium and zirconium in the composite oxide is in a range from 43:57 to 48:52 in terms of molar ratio ([cerium]: [zirconium]). An intensity ratio of a diffraction line at 2θ=14.5° to a diffraction line at 2θ=29° {I(14/29) value} and an intensity ratio of a diffraction line at 2θ=28.5° to the diffraction line at 2θ=29° {I(28/29) value}, which are calculated from an X-ray diffraction pattern obtained by an X-ray diffraction measurement using CuKa after heating under a temperature condition of 1100° C. in air for 5 hours, respectively satisfy the following conditions: | 2013-01-31 |
20130029841 | CATALYST COMPOSITIONS FOR PRODUCING MIXED ALCOHOLS - Catalyst compositions for producing mixed alcohols from a synthesis gas feed. The catalyst composition comprises a catalytic metal combination on a catalyst support, a first optional promoter and a second optional promoter, where the catalytic metal combination consists essentially of iridium, vanadium, and molybdenum. | 2013-01-31 |
20130029842 | CORE-SHELL TYPE METAL NANOPARTICLES AND METHOD FOR PRODUCING THE SAME - The present invention provides core-shell type metal nanoparticles having a high surface coverage of the core portion with the shell portion, and a method for producing the same. Disclosed is core-shell type metal nanoparticles comprising a core portion comprising a core metal material and a shell portion covering the core portion, wherein the core portion substantially has no {100 } plane of the core metal material on the surface thereof. | 2013-01-31 |
20130029843 | SOL-GEL DERIVED COMPOSITIONS - Disclosed are sol gel derived materials obtained from at least one first precursor and at least one second precursor, as well as sol gel derived compositions containing a plurality of alkylsiloxy substituents obtained from such sol-gel derived materials. | 2013-01-31 |
20130029844 | Cyclotides Having Nematocidal Activity and Methods of Use Thereof - The invention provides novel cyclotide polypeptides, and variants and fragments thereof, obtained from Butterfly pea and having pesticidal activity against nematodes. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, biopesticide compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant-parasitic pests such as nematodes and insects. | 2013-01-31 |
20130029845 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS - Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, | 2013-01-31 |
20130029846 | Fungicidal Iminoderivatives - The present invention relates to the use of bicyclic amidine compounds of formula I as defined in the description, and the N-oxides, and salts thereof for combating harmful fungi, and also to compositions and seed comprising at least one such compound. The invention also relates to novel bicyclic amidines and processes and intermediates for preparing these compounds. | 2013-01-31 |
20130029847 | Early Applications of Encapsulated Acetamides for Reduced Injury in Crops - Methods of reducing injury to crop foliage and achieving weed control using encapsulated acetamide herbicides in pre-plant or preemergence crop plant applications are described. A composition comprising a first population of a particulate microencapsulated acetamide herbicide and a second population of a particulate microencapsulated acetamide herbicide is described wherein the application mixture exhibits a bimodal acetamide release profile. The compositions provide reduced crop injury through controlled herbicide release. | 2013-01-31 |
20130029848 | LOW-LOSS SUPERCONDUCTING DEVICES - Low-loss superconducting devices and methods for fabricating low loss superconducting devices. For example, superconducting devices, such as superconducting resonator devices, are formed with a (200)-oriented texture titanium nitride (TiN) layer to provide high Q, low loss resonator structures particularly suitable for application to radio-frequency (RF) and/or microwave superconducting resonators, such as coplanar waveguide superconducting resonators. In one aspect, a method of forming a superconducting device includes foaming a silicon nitride (SiN) seed layer on a substrate, and forming a (200)-oriented texture titanium nitride (TiN) layer on the SiN seed layer. | 2013-01-31 |
20130029849 | SUPERCONDUCTING MAGNET SYSTEM - A superconducting magnet system includes a coil support structure, superconducting coils, and electrically and thermally conductive windings. The superconducting coils and the conductive windings are supported by the coil support structure. Each conductive winding is electromagnetically coupled with a corresponding superconducting coil. Each conductive winding is electrically shorted. | 2013-01-31 |
20130029850 | Competitive Differential Screening - The invention is drawn to a novel method useful for screening. In particular, the present invention provides methods for competitive differential screening. In some preferred embodiments, the present invention provides methods for competitive differential screening that facilitate the identification of tight binders. In some preferred embodiments, the agents used in the methods of the present invention comprise tight and weak binders. In other embodiments, the present invention provides methods that utilize competitive binders that recognize and bind targets, but with binding that is less strong than that of binders of interest. | 2013-01-31 |
20130029851 | CALORIMETER SENSOR - A calorimeter device includes various components located on a common substrate. A first (calorimeter) integrated chip device is located on the substrate. This first device has a first microfluidic channel that has first side and a second side. A first heat sensing circuit is located on the first side of the first channel and a second heat sensing circuit is located on the second side of the channel, opposite the first side and facing the first heat sensing circuit. A second integrated chip device is located on the substrate and proximal to the first device. The second device includes a second microfluidic channel having a fourth side and fifth side. A third heat sensing circuit is located on the third side of the second channel. A fourth heat sensing circuit is located on the fourth side of the channel, opposite the third side and facing the third heat sensing circuit. | 2013-01-31 |
20130029852 | DETECTING AND CLASSIFYING COPY NUMBER VARIATION - The invention provides a method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions. CNV that can be determined according to the method include trisomies and monosomies of any one or more of chromosomes 1-22, X and Y, other chromosomal polysomies, and deletions and/or duplications of segments of any one or more of the chromosomes, which can be detected by sequencing only once the nucleic acids of a test sample. | 2013-01-31 |
20130029853 | CLASSIFICATION OF NUCLEIC ACID TEMPLATES - Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid. | 2013-01-31 |
20130029854 | Method for Determining an Attribute Profile of Biological Samples - A method of identifying attributes in a plurality of biological samples including the steps of determining a source tag sharing number “d” for each of the attributes; providing a plurality of pools for the source tag sharing number “d” wherein each pool comprising a pooled subset of biological samples; for each pool of the plurality of pools, producing at least one pooled pool comprising attribute-specific reaction products comprising a marker tag that uniquely identifies an attribute and a source tag identifying said pool; and identifying said attribute-specific reaction products to identify the attributes. If “d” is equal to or larger than a maximum pool size, the reaction products may not comprise a source tag identifying each pool. Attributes may be binned together. | 2013-01-31 |
20130029855 | Sieving of Nucleic Acid Samples - A method of selecting nucleic acid samples from a plurality of nucleic acid samples based on desired alleles including the steps of performing a first reaction in a plurality of pools of the alleles to be identified to produce reaction products including a source tag identifying said each pool; pooling the pools to provide pooled pools; for each of the desired alleles to be identified, performing a second reaction using said reaction products to produce allele-specific second reaction products comprising a marker tag and a derived source tag; identifying said allele-specific second reaction products to select nucleic acid sample. In some embodiments, the first reaction may not be performed. A source tag sharing number “d” may be determined for each of the alleles. Alleles may be binned together. | 2013-01-31 |
20130029856 | Transfer Or Interrogation Of Materials By Carrier And Receiving Devices Moving Independently And Simultaneously On Multiple Axes - Material transfer/interrogation devices (e.g. liquid handling workstations) have been designed in the past for transferring material from a source to a destination location or for interrogating a material at a location, where the locations remain fixed. The invention provides methods and apparatuses for transferring or interrogating materials by one or more carrier devices to one or more receiving devices, where the carrier and receiving devices move independently and simultaneously on multiple axes. In some embodiments, one or more of the carrier and receiving devices can move along an X, Z, Y, and Theta axis, which allows the source and destination locations to rotate and translate relative to each other. Due to this rotation and translation, containers can be positioned to minimize the distance traveled between a pick location from the source and a place location on the destination, greatly increasing the speed at which material transfer can occur. | 2013-01-31 |
20130029857 | METHOD FOR DETERMINING AN ALLELE PROFILE OF NUCLEIC ACID - A method of identifying alleles of polymorphic sites in a plurality of nucleic acid samples including the steps of determining a source tag sharing number “d” for each of the alleles; performing a first reaction in a plurality of pools of the alleles to be identified to produce reaction products including a source tag identifying said each pool; pooling the pools to provide pooled pools; for each of the alleles to be identified, performing a second reaction using said reaction products to produce allele-specific second reaction products comprising a marker tag and a derived source tag; identifying said allele-specific second reaction products to identify the alleles. If “d” is equal to or larger than a maximum pool size, the first reaction may not be performed. Alleles may be binned together. A microparticle comprising one or more capture probes each comprising an oligonucleotide complementary to a subsequence of a target polynucleotide. | 2013-01-31 |
20130029858 | Method of Drug Screening through Quantitative Detection by Atomic Force Microscopy and Effective Protein Chips Development through Method Thereof - A method for drug screening is provided. An atomic force microscopy (AFM) is used to obtain quantitative difference. At least one receptor is immobilized on a probe of the AFM and at least one ligand is immobilized on chips. By flowing a candidate drug on the chips or even applying different candidate drugs to different areas of each chip, drug screening is processed through measuring the binding force between the receptor and the ligand. Multiple drugs can be screened without weakening activity of the proteins during repeated drug screening processes. The drug screening process is cost saved and has high quality. Highly effective protein chips can be developed based on the present disclosure. | 2013-01-31 |
20130029859 | BIOMARKER ASSAY OF NEUROLOGICAL CONDITION - A process and assay for determining the neurological condition in a subject is provided whereby the level of one or more neuroactive biomarkers is measured in a sample obtained from the subject. The processes and assay include measurement of multiple neuroactive biomarkers for synergistic determination of a neurological condition such as neurological damage due to injury, disease, contact with a compound, or other source. | 2013-01-31 |
20130029860 | Methods Of Diagnosing Or Treating Prostate Cancer Using The ERG Gene, Alone Or In Combination With Other Over Or Under Expressed Genes In Prostate Cancer - The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and/or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene. | 2013-01-31 |
20130029861 | Method for Detecting a Plurality of Nucleotide Polymorphisms at a Single Wavelength Using a Plurality of Oligonucleotides Modified With Fluorescent Dye Having the Same or Close Detection Wavelength - The present disclosure includes a method for simultaneously detecting a plurality of nucleotide polymorphisms, comprising detecting a plurality of nucleotide polymorphisms at a single wavelength by using a plurality of oligonucleotides labeled with a dye, each of which hybridizes to a region containing each of the plurality of nucleotide polymorphisms. | 2013-01-31 |
20130029862 | Clinical application utilizing genetic data for effective medication management - The present disclosure relates a predictive method, based on a subject's genetic profile, which defines variability in a specific disease or condition to determine medication response, including determining select VNTR and SNP occurrence combinations which are associated with specific responses to medications, kits and DNA chips/arrays containing such combinations so as to effectuate better medication management. | 2013-01-31 |
20130029863 | METHOD FOR DETECTING MICROORGANISMS - The invention relates to the diagnostic field and to the characterization of antibiotic-resistant bacteria in a sample by detecting specific nucleotides in the CMY-2 gene. | 2013-01-31 |
20130029864 | BIOMARKERS FOR ALZHEIMER'S DISEASE - The invention relates to novel marker sequences for Alzheimer's disease, in particular Alzheimer's dementia, and their diagnostic use including a screening method in order to identify potential drugs for the treatment/prophylaxis of Alzheimer's disease by means of the said novel marker sequences. Moreover, the invention relates to a diagnostic device comprising said novel marker sequences for diagnosing Alzheimer's disease, particularly a protein array (chip) and its use hereto. | 2013-01-31 |
20130029865 | Stromal Antigen 2 (STAG2) Compositions and Methods - Compositions and methods related to stromal antigen 2 (STAG2) and its role in diverse human cancers, including nucleic acids, polypeptides, vectors, cells and cell lines. | 2013-01-31 |
20130029866 | CARDIOMYOCYTES FROM INDUCED PLURIPOTENT STEM CELLS FROM PATIENTS AND METHODS OF USE THEREOF - Human somatic cells obtained from individuals with a genetic heart condition are reprogrammed to become induced pluripotent stem cells (iPS cells), and differentiated into cardiomyocytes for use in analysis, screening programs, and the like. | 2013-01-31 |
20130029867 | CONCENTRATION MEASUREMENT METHOD AND CONCENTRATION MEASUREMENT SYSTEM - A concentration measurement method for measuring the concentration of a target molecule, capable of carrying out a quantitative measurement of the concentration by use of a chip. A relationship between concentration of a target molecule of a calibration liquid, found with respect to a calibration chip identical in performance to the measurement chip and a measured quantity of light is found when the probe molecule and the target molecule undergo bonding reaction in a condition where the specific probe molecule and the target molecule undergo bonding reaction using the calibration chip. The concentration of a target molecule in the measured target liquid is worked out on the basis of the measured quantity of light, found in the step of finding the measured quantity of light by use of a relationship found with respect to a calibration chip | 2013-01-31 |
20130029868 | METHODS AND KITS FOR THE DETECTION OF CANCER INFILTRATION OF THE CENTRAL NERVOUS SYSTEM - This invention relates to methods to detect the presence of cancer infiltration of the Central Nervous System (CNS) based on the detection of soluble proteins, preferably, in cerebrospinal fluid samples and vitreous fluid. The invention also relates to kits to perform the methods of the invention. | 2013-01-31 |
20130029869 | Molecular Profile For the Diagnosis of Metabolic Myopathies - Provided is a method for determining whether an individual is at risk for, or has a metabolic muscle disease. The method involves testing a biological sample obtained or derived from an indivdival for the presence or absence of at least one mutation from a plurality of mutations in genes related to muscle metabolism and identifying the individual as having or at risk for developing a metabolic muscle disease based on the presence or absence of the mutation. | 2013-01-31 |
20130029870 | MATERIALS AND METHODS FOR DIAGNOSIS OF ASTHMA - The present invention pertains to materials and methods for diagnosing and/or determining the prognosis and likelihood of developing asthma. In one embodiment, methods of the invention comprise the use of single nucleotide polymorphic markers of asthma. Markers of the invention are present in the atria natriuretic peptide (NPPA) gene, and serve as a marker for genetic susceptibility of a person or animal in developing asthma. | 2013-01-31 |
20130029871 | METHODS OF STRATIFYING ADOLESCENT IDIOPATHIC SCOLIOSIS, ISOLATED NUCLEIC ACID MOLECULES FOR USE IN SAME AND KITS USING SAME - A method of stratifying a subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting Paired-like homeodomain transcription factor 1 (Pitx1) expression in the cell sample; whereby the results of the detecting step enables the stratification of the subject having AIS as belonging to an AIS subclass. | 2013-01-31 |
20130029872 | ARRAY FOR DETECTING BIOLOGICAL SUBSTANCE, ASSAY SYSTEM AND ASSAY METHOD - Provided are a device, whereby cells, a bacterium or a virus can be quantified in a single unit, an assay system and an assay method. A subject to be assayed such as cells, a bacterium or a virus, which are present on a sensor, can be quantified by using a sensor equipped with multiple electrodes, said electrodes being similar in size to the subject to be assayed, detecting, concerning each electrode, the presence or absence of the subject in the vicinity of the electrode, and adding up the electrodes in which the subject is detected. | 2013-01-31 |
20130029873 | METHODS AND COMPOSITIONS FOR DIAGNOSING PULMONARY FIBROSIS SUBTYPES AND ASSESSING THE RISK OF PRIMARY GRAFT DYSFUNCTION AFTER LUNG TRANSPLANTATION - A method for determining pulmonary fibrosis subtype and/or prognosis in a subject having pulmonary fibrosis comprising: a. determining an expression profile by measuring the gene expression levels of a plurality of genes selected from genes listed in Table 1, 2, 3, 4 7, 8, 9, and/or 10, in a sample from the subject; and b. classifying the subject as having a good prognosis or a poor prognosis based on the expression profile; wherein a good prognosis predicts decreased risk of post lung transplant primary graft dysfunction, and wherein a poor prognosis predicts an increased risk of post lung transplant primary graft dysfunction. | 2013-01-31 |
20130029874 | MICRORNA MARKERS FOR RECURRENCE OF COLORECTAL CANCER - The present invention concerns methods and compositions for identifying a miRNA profile for a particular condition, such as colorectal cancer, and using the profile in the diagnosis and/or prognosis of a patient for a condition, such as colorectal cancer and colorectal cancer recurrence or response to therapy. | 2013-01-31 |
20130029875 | TEMPLATED ISLET CELLS AND SMALL ISLET CELL CLUSTERS FOR DIABETES TREATMENT - Substrates and devices for culturing cells are disclosed, along with methods of using the same. The substrates and devices include top surfaces with one or more divots disposed therein. Each divot is defined by an opening in the top surface, a rounded bottom surface spaced from the opening, and an interior side-wall surface extending between the rounded bottom surface and the opening. The top surface of the substrates and devices are optionally walled to form wells containing one or more divots. The substrates and devices may be used for reaggregating cells, for example, to form small islet cell clusters and for high throughput testing methodologies. | 2013-01-31 |
20130029876 | Nucleic Acids and Libraries - The invention relates to a nucleic acid comprising the following contiguous elements arranged in the 5 prime to 3 prime direction; a promoter; a selectable marker; a cloning site for receipt of a nucleic acid segment, said segment comprising a candidate miRNA target sequence; and a poly adenylation signal, said elements arranged such that a transcript directed by said promoter comprises said selectable marker, said candidate miRNA target sequence, and said poly adenylation signal in that order. Suitably the miRNA test sequence is or is derived from a 3′UTR. The invention also relates to methods for making and screening libraries. | 2013-01-31 |
20130029877 | METHODS FOR OPTIMIZING OPTICAL MAPPING CONDITIONS - The invention generally relates to methods and apparatuses for optimizing conditions for optical mapping. In certain embodiments, methods of the invention involve providing a substrate including a gradient of silanes in a first direction, introducing to the substrate, a gradient of enzyme activity in a second direction, contacting a plurality of enzymes and a plurality of nucleic acids to the substrate, and analyzing enzymatic activity and interaction of the nucleic acids with the substrate, thereby determining the optimal conditions for optical mapping of the nucleic acid. | 2013-01-31 |
20130029878 | Method for Assaying Histone Methylation Enzyme Activity - Provided are a method for measuring histone methyltransferase activity, a method for screening for compounds that inhibit histone methyltransferase activity, a reagent kit for measuring histone methyltransferase activity, and a kit for screening for compounds that inhibit histone methyltransferase activity. A substrate compound represented by general formula (I): R | 2013-01-31 |
20130029879 | Methods and Systems for Cell State Quantification - Systems, methods, libraries, kits, and computer software tools are provided for designing and producing engineered cells. Such engineered cells can be used for cell state quantification, such as genome, transcriptome and/or proteome quantification. In one aspect, an engineered cell having a plurality of artificially designed oligonucleotides introduced into the genome of the cell is provided. The oligonucleotides are each located in proximity of a gene of interest encoding a protein of interest, and are different from one another. The oligonucleotides can each encode a unique peptide tag for each protein of interest, wherein each peptide tag has a unique quantitatively measurable value such as mass-to-charge ratio which can be quantified by a mass spectrometer. The engineered cell is capable of expressing a plurality of proteins of interest each fused to its corresponding unique peptide tag, wherein each peptide tag is capable of being released therefrom. | 2013-01-31 |
20130029880 | METHODS OF SYNTHESIZING HETEROMULTIMERIC POLYPEPTIDES IN YEAST USING A HAPLOID MATING STRATEGY - Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell. The transformed haploid cells, each individually synthesizing a non-identical polypeptide, are identified and then genetically crossed or fused. The resulting diploid strains are utilized to produce and secrete fully assembled and biologically functional hetero-multimeric protein. | 2013-01-31 |
20130029881 | SELECTIVE TERMINAL TAGGING OF NUCLEIC ACIDS - Methods are provided for adding a terminal sequence tag to nucleic acid molecules for use in RNA or DNA amplification. The tag introduced may be used as a primer binding site for subsequent amplification of the DNA molecule and/or sequencing of the DNA molecule and therefore provides means for identification and cloning of the 5′-end or the complete sequence of mRNAs. | 2013-01-31 |
20130029882 | Nucleic Acids and Libraries - The invention relates to a nucleic acid comprising the following contiguous elements arranged in the 5 prime to 3 prime direction; a promoter; a selectable marker; a cloning site for receipt of a nucleic acid segment, said segment comprising a candidate miRNA target sequence; and a poly adenylation signal, said elements arranged such that a transcript directed by said promoter comprises said selectable marker, said candidate miRNA target sequence, and said poly adenylation signal in that order. Suitably the miRNA test sequence is or is derived from a 3′UTR. The invention also relates to methods for making and screening libraries. | 2013-01-31 |
20130029883 | GAS GENERATING SYSTEM FOR STIMULATION AND DELIQUIFICATION - A gas generating system for use in stimulation or in deliquification/dewatering includes a foam generating agent, a foam enhancing agent and a gas generating additive. The foam generating agent is absorbed or adsorbed on a first plurality of substrates and the foam boosting agent is absorbed or adsorbed on a second plurality of substrates. The gas generating additive preferably includes an acidic component contained within a releasing mechanism container and a carbonate or bicarbonate contained within a releasing mechanism container. The use of encapsulated substrate permits the staged and targeted delivery of treatment chemicals in fractures extending from the wellbore or in the wellbore itself. | 2013-01-31 |
20130029884 | BIOCIDE FORMULATIONS - Biocide compositions comprising biocide, surfactant, and solubilizing agent. The preferred biocide is parachlorometaxylenol. The biocide composition is useful in oil and gas drilling operations, such as hydraulic fracturing, as well as treating aqueous slurries in ore mining operations. The biocide compositions are effective in controlling microorganisms even in the presence of high salt content water and at high temperatures. | 2013-01-31 |
20130029885 | METHOD FOR PRODUCING EXPANDED GLASS GRANULES AND EXPANDED GLASS GRANULES AND THE USE THEREOF - The invention relates to a method for producing expanded glass granules. To this end, starting materials are provided, comprising 80% to 95% glass and 5% to 20% sodium silicate hydrate having a water of crystallization content between 1 and 2 wt %, in relation to the solids content. After the glass is ground, the starting materials are mixed, the ground starting materials are granulated into raw granules, and the raw granules are mixed with a release agent, the mixture comprising the raw granules and the release agent is heated to a processing temperature. In a first partial step, the pores on the surfaces of the particles of the raw granules are closed, and in a second partial step, the water of crystallization is dissolved from the sodium silicate hydrate and caused to thermally expand, whereby the particles of the raw granules expand and form the expanded glass granules. | 2013-01-31 |
20130029886 | METHOD OF CONTROLLING THE CORROSION RATE OF ALLOY PARTICLES, ALLOY PARTICLE WITH CONTROLLED CORROSION RATE, AND ARTICLES COMPRISING THE PARTICLE - A composite particle comprises a core, a shielding layer deposited on the core, and further comprising an interlayer region formed at an interface of the shielding layer and the core, the interlayer region having a reactivity less than that of the core, and the shielding layer having a reactivity less than that of the interlayer region, a metallic layer not identical to the shielding layer and deposited on the shielding layer, the metallic layer having a reactivity less than that of the core, and optionally, an adhesion metal layer deposited on the metallic layer. | 2013-01-31 |
20130029887 | PROCESS AND APPARATUS FOR MANUFACTURING GREASE - A process and corresponding apparatus and system for use in preparing soaps from fatty acid containing oil compositions, and in turn, for preparing greases by the use of such soaps in combination with one or more base oils. | 2013-01-31 |
20130029888 | LUBRICATING GREASE COMPOSITION - A lubricating grease composition for extra heavy duty extreme pressure applications comprises a major amount of a synthetic base oil a lithium complex thickener, at least one extreme pressure agent; and at least 5 wt. % of molybdenum disulfide, based on a total weight of the lubricating grease composition. | 2013-01-31 |
20130029889 | Low-Ash Lubricating Oils for Diesel Engines - The lubricant for a sump-lubricated, compression-ignited engine may contain an amount of a C12-C24 carboxylic acid-based fuel additive or component obtained by migration from the fuel. Good lubricant performance is obtained by including in the lubricant a boron-containing additive in an amount to provide about 2 to about 500 ppm B to the lubricant, provided that the total sulfated ash level is less than 0.8 weight percent. | 2013-01-31 |
20130029890 | Lubricating Oil Composition and Method for Operating Automatic Transmission - A lubricating oil composition containing a bis-type alkenyl-substituted succinimide which is prepared by reaction of succinic anhydride substituted with 2-alkenyl group having a branched structure in β-position with alkylenepolyamine or a compound derived from the bis-type alkenyl-substituted succinimide by post-treatment in combination with a mixture of an overbased sulfonate having a C | 2013-01-31 |
20130029891 | TURBINE OIL COMPRISING AN ESTER COMPONENT - Provided is a turbine oil formulation comprised of a base oil selected from the group consisting of Group II, III and IV base oils and mixtures thereof, and an ester component comprised of at least one diester or triester species having ester links on adjacent carbons. The formulation exhibits less than 6 mg of sludge/100 ml of turbine oil, and is imminently suitable for use as a turbine oil. | 2013-01-31 |
20130029892 | LUBRICATING OIL COMPOSITION FOR INTERNAL COMBUSTION ENGINES - Provided is a lubricant oil composition for an internal combustion engine which is characterized by including a base oil having a viscosity index of 125 or higher and a Noack evaporation amount (250° C.×1 h) of 15% by mass or less, and, based on a total amount of the composition, from 0.1 to 10% by mass of (A) a C | 2013-01-31 |
20130029893 | Process for Preparing a Turbine Oil Comprising an Ester Component - Provided is a process for preparing a turbine oil formulation comprised of a base oil selected from the group consisting of Group II, III and IV base oils and mixtures thereof, and an ester component comprised of at least one diester or triester species having ester links on adjacent carbons. The formulation exhibits less than 6 mg of sludge/100 ml of turbine oil and is imminently suitable for use as a turbine oil. | 2013-01-31 |
20130029894 | MULTIPHASE LIQUID DETERGENT COMPOSITION - The invention relates to a multiphase liquid detergent composition comprising at least two visually distinct liquid phases and a surfactant. At least one of the visually distinct phases has a high shear viscosity between about 100 cps and 15,000 cps at 20° C., a medium shear viscosity between about 5,000 cps and about 60,000 at 20° C., and a low shear viscosity between about 10,000 cps and 500,000 cps at 20° C. The present invention further relates to methods of cleaning dishware using such multiphase liquid detergent compositions. | 2013-01-31 |
20130029895 | MULTIPHASE LIQUID DETERGENT COMPOSITION - The invention relates to a multiphase liquid detergent composition comprising at least one cleaning phase and at least one benefit phase, a surfactant, and a crystalline structurant. The crystalline structurant being substantially present in a non-lamellar phase. The invention also relates to a multiphase liquid detergent composition comprising at least two visually distinct liquid phases, a surfactant, and at least two incompatible or reactive materials. The first incompatible or reactive material is distributed in a first visually distinct phase and a second incompatible or reactive material is distributed in a second visually distinct phase. The present invention further relates to methods of cleaning dishware using such multiphase liquid detergent compositions. | 2013-01-31 |
20130029896 | DETERGENTS HAVING ACCEPTABLE COLOR - This disclosure relates to detergent compositions containing tiron, a ligand capable of binding iron, an iron-displacing species, and iron. Methods for altering the color in a tiron-containing detergent composition are also disclosed. | 2013-01-31 |
20130029897 | Mutated Alkaline Cellulase - The present invention provides a mutant alkaline cellulase having enhanced anti-redeposition ability. The present invention provides a mutant alkaline cellulase having an amino acid sequence in which at least amino acid residue selected from the amino acid residues at the positions corresponding to positions 58, 45, 52, 56, 60, 64, 66, 71, 103, 119, 122, 123, 124, 125, 127, 130, 140, 161, 164, 175, 176, 178, 179, 181, 193, 194, 195, 196, 197, 199, 202, 203, 217, 225, 227, 228, 251, 267, 272, 276, 277, 280, 282, 297, 310, 312, 318, 324, 345, 354, 356, 357, 360, 363, 368, 418, 419, 420, 421, 422, 453, 454, 455, 457, 458, 459, 494, 495, 496, 500, 501, 502, 503, 504, 550, 551, 552, 604, 605, 606, 607, 608, 640, 641, 642, 644, 645, 646, 683, 684, 685, 690, 691, 692, 693, 694, 739, 740, and 741 of the amino acid sequence of an alkaline cellulase set forth in SEQ ID NO: 2 or of the amino acid sequence of an alkaline cellulase having at least 70% identity with the amino acid sequence of SEQ ID NO: 2, is substituted with other amino acid residue. | 2013-01-31 |
20130029898 | Composition - A liquid detergent composition has a thickening system which comprises;
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20130029899 | CONCENTRATED FATTY ACYL AMIDO SURFACTANT COMPOSITIONS - A surfactant concentrate is provided that includes
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20130029900 | NOVEL MAYTANSINOID DERIVATIVES WITH PEPTIDE LINKER AND CONJUGATES THEREOF - The invention relates to novel cell-binding agent-cytotoxic agent conjugate having a peptide linkers and more specifically to conjugates of formula (I). The invention also provides novel cytotoxic agents of formula (II), linker compounds represented by formula (III), and drug-linker compounds represented by formula (IV). The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. | 2013-01-31 |
20130029901 | METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH - Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (R | 2013-01-31 |
20130029902 | CXC CHEMOKINE RECEPTOR 4 (CXCR4) ANTAGONISTIC POLYPEPTIDE - A peptide having the following amino acid sequence: | 2013-01-31 |
20130029903 | Azuvirin Peptides - Azuvirin peptides are small peptide agents useful in delivering functional moieties, such as sensitizers, chemotherapeutic agents and the like to cancer cells expressing ephrin receptors. The peptides are also useful for administration to a patient suffering from a viral infection, or to an individual facing exposure to a viral infection, especially one caused by the HIV-1 retrovirus. | 2013-01-31 |
20130029904 | HCV COMBINATION THERAPY - Aspects of this invention include methods comprising administering a combination of a Compound (1) below, including particular en crystalline forms thereof and pharmaceutically acceptable salts thereof, with at least one further selected HCV inhibiting compound as described herein for the treatment of Hepatitis C Viral (HCV) infection The methods can be conducted administering the Compound (1) and the at least one further selected HCV inhibiting compound separately or together, including as a regimen of treatment. | 2013-01-31 |
20130029905 | FORMULATION CONTAINING CURCUMINOIDS EXHIBITING ENHANCED BIOAVAILABILITY - The present invention relates to a formulation containing curcuminoids exhibiting enhanced in vivo bioavailability and resultant improved efficacy, said formulation comprising curcuminoids and a gel forming, non digestive and soluble dietary polysaccharide fiber galactomannan and proteins derived from fenugreek [ | 2013-01-31 |
20130029906 | METHOD OF REGULATING PPAR, OBESITY RELATED PATHWAYS AND THEIR ASSOCIATED METABOLIC IMPACT - It is disclosed a method of modulating a peroxisome proliferator activated receptor (PPAR) activity in a patient comprising administering to said subject an effective amount of a malleable protein matrix (MPM), uses thereof and pharmaceutical compositions comprising MPM for treating obesity related disorders and their associated metabolic impact by modulating PPAR activity. | 2013-01-31 |
20130029907 | Novel Polypeptides That Bound to IL-23 Receptor and Inhibit Binding of IL-23 and Cell Signaling Thereof - The present invention relates to novel polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The novel polypeptides of the present invention has a core structure of WX | 2013-01-31 |
20130029908 | CERBERUS/COCO DERIVATIVES AND USES THEREOF - The invention relates to Cerberus/Dan/Gremlin polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11. Preferred polypeptides are Coco or Cerberus derivatives. | 2013-01-31 |
20130029909 | TREATMENT OF CANCER - Provided are methods relating to compositions that include a CDP-topoisomerase inhibitor, e.g., a CDP-camptothecin or camptothecin derivative conjugate, e.g., CRLX101. | 2013-01-31 |
20130029910 | METHOD OF TREATING PROSTATE CANCER WITH GnRH ANTAGONIST - The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and/or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect. The present disclosure also provides for methods for treating prostate cancer in a patient with a history of at least one cardiovascular event, wherein administration of degarelix to the subject decreases the likelihood of developing or experiencing an additional cardiovascular event compared to treatment with a gonadotrophin releasing hormone (GnRH) agonist. | 2013-01-31 |
20130029911 | ALBUMIN FUSION PROTEINS - The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention. | 2013-01-31 |
20130029912 | TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA, HEMOLYTIC ANEMIAS AND DISEASE STATES INVOLVING INTRAVASCULAR AND EXTRAVASCULAR HEMOLYSIS - Methods for treating subjects having complement-mediated hemolytic disorders, such as paroxysmal nocturnal hemoglobinuria (PNH) and other hemolytic anemias, the method comprising administering an effective amount of a composition that inhibits the activity of the complement alternative pathway. | 2013-01-31 |
20130029913 | ARTIFICIAL PLATELETS - Therapeutic agents suitable for use as artificial platelets are described. The agents comprise a fibrinogen binding precursor bound to an insoluble carrier, wherein the fibrinogen binding precursor can be converted by a wound site specific agent, such as thrombin, to a fibrinogen binding component bound to the carrier. The fibrinogen binding component has increased ability to bind fibrinogen compared to the fibrinogen binding precursor. The agents may be used to treat patients with deficiencies in their own platelets, such as hereditary or acquired defects of platelet numbers (thrombocytopenia) or function (thrombasthenia). | 2013-01-31 |
20130029914 | SEBUM SECRETION-BLOCKING COMPOSITION, AND FOOD OR BEVERAGE CONTAINING SAME - An object is to provide a sebum secretion inhibiting composition and a food or drink product using the same. The present inventors have conducted extensive studies and consequently found that the sebum secretion is inhibited by orally ingesting a collagen peptide, which is hydrolyzed collagen, and provide an oral sebum secretion inhibiting composition comprising a collagen hydrolysate and a food or drink product containing the composition. | 2013-01-31 |
20130029915 | CROSSLINKED HUMAN OR ANIMAL TISSUE PRODUCTS AND THEIR METHODS OF MANUFACTURE AND USE - Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation. | 2013-01-31 |
20130029916 | TREATMENT OF MULTIPLE SCLEROSIS WITH COMBINATION OF LAQUINIMOD AND GLATIRAMER ACETATE - This invention provides a method of treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the patient laquinimod as an add-on therapy to or in combination with glatiramer acetate. This invention also provides a package and a pharmaceutical composition comprising laquinimod and glatiramer acetate for treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention also provides laquinimod for use as an add-on therapy or in combination with glatiramer acetate in treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention further provides use of laquinimod and glatiramer acetate in the preparation of a combination for treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome. | 2013-01-31 |
20130029917 | USE OF A PEPTIDE HYDROLYSATE OF PEA AS MOISTURIZING ACTIVE AGENT - The invention relates to the cosmetic use of a peptide hydrolysate of pea ( | 2013-01-31 |
20130029918 | METHODS FOR REDUCING VEIN IRRITATION - The present invention provides compositions for delivering highly water-soluble drugs (such as vinca alkaloids) and methods of using such compositions. | 2013-01-31 |
20130029919 | TWO PART FORMULATION SYSTEM FOR OPTHALMIC DELIVERY - Ophthalmic products and related methods are described herein. These methods include a stabilizing composition comprising a therapeutically active agent which is separated from a liquid vehicle composition by a barrier. The barrier may be removed to allow the two compositions to mix to provide an ophthalmically acceptable liquid comprising the therapeutically active agent. | 2013-01-31 |
20130029920 | Metal Nanoparticles - A metal nanoparticle-phosphopeptide complex comprising a metal nanoparticle and a phosphopeptide is provided. The phosphopeptide comprises two or more contiguous peptide motifs and two or more phosphorus-containing groups capable of interacting with the surface of the metal nanoparticle. The amino acids at the equivalent position in each peptide motif have similar structural and/or electronic properties. Each phosphorus-containing group is bound to an amino acid in the two or more contiguous peptide motifs. Methods for preparing the metal nanoparticle-phosphopeptide complex are also provided. | 2013-01-31 |
20130029921 | INHIBITING PEPTIDES DERIVED FROM TREM-LIKE TRANSCRIPT 1 (TLT-1) AND USES THEREOF - The present invention relates to polypeptides fragments derived from the protein TLT-1 and their uses for the treatment of inflammatory conditions and more particularly for the treatment of sepsis. | 2013-01-31 |