04th week of 2009 patent applcation highlights part 36 |
Patent application number | Title | Published |
20090023117 | Books of the bible - The Book of the Bible game effectively teaches the order of the books from Genesis to Revelation. The game consists of 66 cards (one-half inch). Game pieces will vary in languages, fonts, colors and logos (personal and authorized organizations). First Level: Cards are placed on a flat surface with the names of the bible facing upward. The player must arrange the cards in which he/she believes to be the correct order of the books of the bible. Accuracy is determined by the sequence of numbers. The player continues this level until it is mastered. Second Level: Cards are placed on a flat surface with the numbers facing upward in the correct number sequence 1-66. Beginning with the first book of the bible the player must say the name of the book aloud before turning over the card. The player continues this level until it is mastered. | 2009-01-22 |
20090023118 | Mathematical education system - An apparatus for teaching mathematical concepts is set forth. The apparatus includes a display. A code for at least one ones number is selected from the group consisting of Arabic numerals 0,1,2,3,4,5,6,7,8,9. At least one non-numeric shape for at least one tens number is selected from sets of numbers, the sets of numbers consisting of 10-19, 20-29, 30-39, 40-49, 50-59, 60-69, 70-79, 80-89, and 90-99. The code and the at least one non-numeric shape are presented in association with one another on the display to form a numerical identity. The numerical identity has a value determined by the code and the at least one non-numeric shape. | 2009-01-22 |
20090023119 | Method for learning a foreign language - A method for learning a foreign language using a learning aid is provided. The learning aid includes a reading manual having a plurality of pages organized into a number of sections which are read in an orderly fashion in order to facilitate incremental advancement and masterfulness concerning the learning of a target language. The method involves building an active foreign language alphabet and language as it is done naturally in user's native language. | 2009-01-22 |
20090023120 | PROGRAM TO INTENSIVELY TEACH A SECOND LANGUAGE USING ADVERTISEMENTS - An immersion method teaches a student conversational speech aspects of a language (such as a second language) while, in the process, intensively exposing the student to a relevant conversational program (such as advertising) as an integral part of the teaching process. The method may include displaying, to the user/student, portions of video and audio of a conversational program (such as an advertisement in a second language), while causing a textual indication of the displayed audio to be simultaneously displayed (e.g., in the second language and a native language). The user may be prompted for information indicative of comprehension of the program by the user. Particularly in the case of advertising, information indicative of comprehension of the program can be very useful to the advertiser, as well as the prompting process itself serving to reinforce themes presented in the advertisement. | 2009-01-22 |
20090023121 | Word problem solving apparatus - The present invention provides a method and apparatus which assists a student in their approach and understanding to solving algebraic word problems. The invention includes a predetermined set of word problems. The student solves the word problem by selecting appropriate rate bars which are responsive to a selected word problem and placing the selected rate bars in proper placement with respect to a measurement line. The student also selects the proper equation, which also includes pre-solved solutions for the selected word problem. The student thus solves the problem through the use of the rate bars alone or in conjunction with a parallel solution provided in the pre-solved equation. | 2009-01-22 |
20090023122 | Motor Learning And Rehabilitation Using Tactile Feedback - There is disclosed a process for motor learning, for teaching motion, or for rehabilitation of a student, the student having a motor sensory system. Plural transducers may be coupled around at least one joint of a student, the transducers for providing kinesthetic sensations to the student through its motor sensory system. Tactile control signals may be provided to control operation of the transducers to guide motions of the student. | 2009-01-22 |
20090023123 | AUDIO INPUT DEVICE AND KARAOKE APPARATUS TO DETECT USER'S MOTION AND POSITION, AND ACCOMPANIMENT METHOD ADOPTING THE SAME - An audio input device and a karaoke apparatus to detect user's motion and position, and an accompaniment method adopting the same. According to the audio input device and the karaoke apparatus, at least one of user's motion information and position information is detected and transmitted to the karaoke apparatus through a USB interface. Accordingly, the user can use diverse functions of the karaoke apparatus more conveniently. | 2009-01-22 |
20090023124 | Software Application System as an Efficient Client or Case Management Tool - A web application that facilitates the interaction between an educational institution and its members for the purpose of assisting a student in need is described. The application provides an accessible and user-friendly system for members of an educational institution to provide and gather information. The application may perform various functions that allow rapid and efficient transmission of information regarding a student in need so that those needs may be addressed. | 2009-01-22 |
20090023125 | LOCK-IN TRAINING SYSTEM PROGRESS DISPLAY - A Lock-In Training system. The Lock-In Training system can include an appropriately programmed Web site and a user computer. The Lock-In Training system can also include an appropriately programmed stand-alone computer. Some embodiments of the invention allow student users to efficiently learn materials by taking Lock-In Training courses. A Lock-In Training course may include one or more Lock-In Training sessions. These sessions may include one or more Lock-In Training parts. These parts can include a group of questions and answers. The answers can include one or more keywords. A student user can lock-in material by entering keywords in response to questions. The questions may be presented in Introductory rounds and/or Retention rounds on one or more training days. | 2009-01-22 |
20090023126 | Educational Apparatus Utilized in Teaching Children the Dangers of Drugs and Violence - The invention is an transparent apparatus shaped like a human doll, with an opening at its top and an open-end box as its base. The doll can be personalized with a photograph of the child playing with the doll. Several transparent slides to be inserted into or removed from the doll from its top are included, one with a stylized graph of a healthy person's internal organs; the rest, stylized graphs of partially damaged internal organs depicted as black areas as a result of drug use. The integration or disintegration of the image of the black areas of the slides depicts increasing or decreasing damage by drug use. Two non-transparent slides are included, one showing a slogan, the other healthy human organs not damaged by drug abuse. Slides and educational material containing visual illustrations of the death and destruction due to use of weaponry are also included. | 2009-01-22 |
20090023127 | TISSUE SYSTEM AND METHODS OF USE - Apparatus and methods of use of a tissue system for culture and perfusion. The apparatus comprises a needle for injecting a fluid into the tissue. | 2009-01-22 |
20090023128 | STORAGE DEVICE FOR CRYOPRESERVATION OF BIOLOGICAL SAMPLES - A cryopreservation storage device ( | 2009-01-22 |
20090023129 | WHITE BLOOD CELL DIFFERENTIATION REAGENT AND METHOD OF USE THEREOF - The present disclosure provides a white blood cell differentiation reagent comprising a fluorescent dye compound of Formula I, wherein R | 2009-01-22 |
20090023130 | Prevention of Transfusion Related Acute Lung Injury Using Riboflavin and Light - This invention is directed toward a method of preventing the formation of bioactive substances in a pathogen inactivated blood component. The steps include illuminating the blood component with light at a sufficient energy so that an alloxazine photosensitizer present in the blood component may be photolyzed to inactivate any pathogens which may be present; preventing the formation of bioactive substances in the pathogen inactivated blood component; and storing the pathogen inactivated blood component. | 2009-01-22 |
20090023131 | CIRCUIT ARRANGEMENT FOR INJECTING NUCLEIC ACIDS AND OTHER BIOLOGICALLY ACTIVE MOLECULES INTO THE NUCLEUS OF HIGHER EUCARYONTIC CELLS USING ELECTRICAL CURRENT - The invention relates to a novel circuit arrangement for electrotransfection or electrofusion, which enables the transportation of DNA and/or other biologically active molecules to the nucleus of higher eukaryotic cells or the fusion of cells, independent of cell division and with reduced cell mortality. | 2009-01-22 |
20090023132 | Hydraulic device for a blood analysis apparatus, associated method and analysis apparatus equipped with such a device - Hydraulic device for a blood analysis apparatus includes elements | 2009-01-22 |
20090023133 | GENOMIC MARKERS OF HEPATITIS B VIRUS ASSOCIATED WITH HEPATOCELLULAR CARCINOMA - The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC). | 2009-01-22 |
20090023134 | Neoplasia diagnostic compositions and methods of use - The invention generally features compositions and methods for the diagnosis and monitoring of a neoplasia (e.g., a prostatic neoplasia) in a subject, as well as methods of treatment selection. | 2009-01-22 |
20090023135 | DETECTION OF ENHANCED MULTIPLEX SIGNALS BY SURFACE ENHANCED RAMAN SPECTROSCOPY - Various methods of using Raman-active or SERS-active probe constructs to detect analytes in biological samples, such as the nucleic acid and/or protein-containing analytes in a body fluid are provided. | 2009-01-22 |
20090023136 | HSD3B1 sequence variants - Isolated HSD3B1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as are HSD3B1 allozymes. Methods for determining whether a subject contains an HSD3B1 sequence variant also are provided. | 2009-01-22 |
20090023137 | ESR1 and Cervical Cancer - The present invention provides methods and kits for detecting susceptibility to, or the incidence of, cervical cancer in a sample comprising determining the methylation status of the ESR1 gene, optionally as part of a panel of genes. Also provided are methods and kits which involve determining the expression levels of genes including the ESR1 gene in order to diagnose cervical cancer. | 2009-01-22 |
20090023138 | ORAL CANCER MARKERS AND THEIR DETECTION - Methods of detecting progression from precancer to cancer are provided utilizing toluidine blue staining as well as detecting allelic variation at microsatellite loci. An allelic variation in one or more locus is indicative of a progression from precancer to cancer. | 2009-01-22 |
20090023139 | Method For Site-Specifically Introducing Non-Natural Amino Acid Into Protien Using Mitochondrial Protein and Method For Effectively Preparing Trna - This invention is intended to provide a protein synthesis system used for producing a tryptophan analogue-containing non-natural-amino-acid-containing protein that satisfies the following conditions: (i) tRNA that transfers a non-natural amino acid is not recognized by an endogenous aminoacyl tRNA synthetase (aaRS); (ii) it is recognized selectively by aaRS exclusive for a non-natural amino acid; and (iii) endogenous tRNA is not recognized by aaRS exclusive for a non-natural amino acid. In the eukaryotic organism-derived cell-free protein synthesis system, a yeast mitochondrial tryptophanyl tRNA synthetase is used in combination with mitochondrial tRNA | 2009-01-22 |
20090023140 | CROSSLINKING AGENT, CROSSLINKING METHOD, METHOD OF CONTROLLING GENE EXPRESSION, AND METHOD OF EXAMINING GENE FUNCTION - The present invention provides a crosslinking agent which have photodegradable protective groups at two ends to crosslink double-stranded nucleic acid, a nucleic acid and a protein or a polypeptide, or proteins or polypeptides, in particular, double-stranded RNA; a method for crosslinking a double-stranded RNA or the like using the same; a method for regulating gene expression, which can control the expression of a target gene at an arbitrary timing and location; and a method for examining a gene function. | 2009-01-22 |
20090023141 | METHOD FOR DETECTING BACTERIA OF THE GENUS MYCOBACTERIUM (ACID-FAST BACTERIA) AND KIT FOR THE SAME - An object of the present invention is to provide an oligonucleotide for rapidly and conveniently detecting bacteria of the genus | 2009-01-22 |
20090023142 | Methods for Detecting Minimum Residual Disease - The present invention features methods and compositions for identifying markers of minimum residual disease (MRD), as well as markers of metastatic cells. The present invention further provides methods for detecting MRD and metastatic cell in a subject. | 2009-01-22 |
20090023143 | Predicting agent for metastasis - By disclosing part of metastasis mechanisms in cancer cells, the metastatic potential of cancer cells will be determinable. Anti-galectin-9 Ab against galectin-9 is contained as an effective component with or without others, thereby enabling the evaluation or detection of galectin-9 expression levels in cancer cells wherein the metastatic potential of the cancer cells can be assessed or detected. | 2009-01-22 |
20090023144 | METHOD AND ITS KIT FOR QUANTITATIVELY DETECTING SPECIFIC ANALYTE WITH SINGLE CAPTURING AGENT - The invention provides a method and its kit for quantitatively detecting a specific analyte with a single capturing agent. The quantitative detection of a specific analyte with a single capturing agent comprises: firstly combining the tested analyte with a solid phase capturing agent, then labeling analyte which has been trapped by the capturing agent with a report molecule; secondly eluting the labeled analyte from the complex, recombining the tested analyte with a new solid phase capturing agent, and ascertaining the content of analyte by detecting the report molecule's label signal. The kit of the invention comprises a capturing device, a detecting device, a report molecule for labeling and an analysis substance eluate. The advantages of the invention are the need of one single capturing agent, the capability of detecting for many analytes which can't be tested at present, wide application, high sensibility and low noise. The invention can be applied to diagnosis, medical expertise, new medicine development, application of protein micro array and chip, and fundamental research. | 2009-01-22 |
20090023145 | Methods of diagnosing or prognosing Alzheimer's disease - A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, comprising:
| 2009-01-22 |
20090023146 | DEVICE FOR PROCESSING AN ANALYTE AND A METHOD OF PROCESSING AND/OR DETECTING AN ANALYTE USING SAID DEVICE - The present invention relates to a device for processing an analyte and to a method of processing and/or detecting an analyte using said device. | 2009-01-22 |
20090023147 | DIAGNOSTICS AND THERAPEUTICS FOR OSTEOPOROSIS - Diagnostics and therapeutics for osteoporosis, which are bases upon the identification of a subjects IL-1 haplotype and genotype pattern are described. | 2009-01-22 |
20090023148 | Sensors for biomolecular detection and cell classification - A sensor device is provided for detecting an analyte in a sample in which an analyte is bound to a detection reagent to form a bound complex. The device comprises (a) a sample ( | 2009-01-22 |
20090023149 | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy - The present invention features methods, kits, and devices for predicting the sensitivity of a patient to a compound or medical treatment. The invention also features methods for identifying gene biomarkers whose expression correlates to treatment sensitivity or resistance within a patient population or subpopulation. | 2009-01-22 |
20090023150 | DNA Diagnostics Based on Mass Spectrometry - Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity. | 2009-01-22 |
20090023151 | Method For The Labeling And Detection Of Small Polynucleotides - Methods and kits for use in isolating, labeling or detecting a small polynucleotide of interest from a sample. The method entails hybridizing the small polynucleotide to a capture probe, lengthening the small polynucleotide by primer extension and/or ligation, and degrading the capture probe to provide a single stranded extension product. The kits include the capture probe and additional reagents for the extension, ligation and/or degradation reactions. | 2009-01-22 |
20090023152 | Transcription factor MHC class II genes, substances capable of inhibiting this transcription factor and medical uses of these substances - The present invention relates to a transcription factor of MHC class II genes and its derivatives, inhibitors down-regulating the expression of MHC class II molecules, process to identify these inhibitors and medical uses of these inhibitors. | 2009-01-22 |
20090023153 | Targeted modification of chromatin structure - Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences. | 2009-01-22 |
20090023154 | RELATING TO MARKING - The invention provides a marking system, markers and methods of use of such marking systems and markers which enable unique marking of articles and subsequent detection of that marking. In particular the invention provides a marking system, the marking system comprising a plurality of different DNA fragment types, each of the plurality of different DNA fragment types comprising a plurality of different length DNA fragments and a method in which a sample of the DNA fragment type is taken, amplified and analysed to determine the identity of the marker for an article. | 2009-01-22 |
20090023155 | Polyelectrolyte multilayer films at liquid-liquid interfaces and methods for providing and using same - The present invention is directed to methods for providing a polyelectrolyte multilayer film at a liquid-liquid interface. Such methods include steps of sequentially-depositing layers of cationic and anionic polyelectrolytes at a liquid-liquid interface that is formed between immiscible first and second liquids whereby a polyelectrolyte multilayer film is provided at the liquid-liquid interface. In certain preferred embodiments, the first liquid is an aqueous solution and the second liquid is a liquid crystal. In alternative embodiments, the first liquid is an aqueous solution and the second liquid is an oil. The invention further encompasses polyelectrolyte multilayer films provided by the disclosed methods as well as applications utilizing such materials. | 2009-01-22 |
20090023156 | Methods and reagents for quantifying analytes - The present invention relates to methods and reagents for quantifying analytes. More specifically, the present invention related to methods and reagents for measuring one or more analytes present in a sample. | 2009-01-22 |
20090023157 | Proteome epitope tags and methods of use thereof in protein modification analysis - Disclosed are methods for reliably detecting the presence of proteins, especially proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided. | 2009-01-22 |
20090023158 | Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase - The invention provides assays and methods for determining the substrate specificity of gamma secretase inhibitors and for identifying substrate-selective (and substrate isoform-selective) inhibitors of gamma secretase. The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a site specific or substrate specific manner. The invention provides isolated polypeptide sequences comprising modified gamma secretase substrates, and polynucleotide sequences encoding the polypeptide sequences. The invention also provides compounds that inhibit gamma secretase, pharmaceutical compositions comprising such compounds, and methods of treating Alzheimer's disease using such compounds. | 2009-01-22 |
20090023159 | Method for the in vitro diagnosis of alzheimer's disease using a monoclonal antibody - The invention relates to a method for the in vitro diagnosis of Alzheimer's disease using a monoclonal antibody. Said antibody can bind at least to amino acids 12-16 of the β-amyloid peptide, specifically detecting the neuritic plaques which are characteristic of Alzheimer's disease, without detecting diffuse plaques which are not defining characteristics of the disease. Within the neuritic plaques, the monoclonal antibody can detect a different sub-group in the composition of the different deposited isoforms of the β-amyloid peptide, which is associated with the disease progression stage. In addition, the antibody can bind to isoforms of the β-amyloid peptide in biological fluids such as urine. As a result, the inventive monoclonal antibody, the cell lines that produce said antibody and compositions containing same can be used in the in vitro diagnosis of Alzheimer's disease and in determining the disease progression stage. | 2009-01-22 |
20090023160 | Antibodies specific for CYP1B1 - Antibodies that can specially bind to cytochrome P450 CYP1B1 and methods of making them are disclosed, in particular antibodies that bind to amino acid sequence VNQWSVNHDPVKWPN or PExFDPARFLDKDGy, where x is D or N and y is L or F, or an antigenic fragment thereof. The antibodies can be used in the diagnosis or treatment of cancers linked to enhanced CYP1B1 expression, including breast cancer, prostate cancer, colorectal cancer, liver cancer and ovarian cancer. | 2009-01-22 |
20090023161 | STRUCTURAL BASIS FOR TARGETING HIV-1 GAG PROTEINS TO THE PLASMA MEMBRANE FOR VIRUS ASSEMBLY - The present invention provides for testing methods to determine an effective testing agent that affects the activity of the HIV Gag protein at the plasma membrane of a cell, and specifically, effecting changes in the structural conformation of at least one fatty acid of PI(4,5)P | 2009-01-22 |
20090023162 | METHOD FOR THE IDENTIFICATION OF ATYPICAL P-ANCA - The invention relates to a method for the identification of atypical p-ANCA, kits suitable for the same and application of said method to the diagnosis of chronic inflammatory intestinal diseases and autoimmune liver diseases. | 2009-01-22 |
20090023163 | Method of Measuring Enzyme Activity and Method of Evaluating Compound - It is intended to provide a method of measuring an activity, which is a method of measuring an activity of an enzymatic reaction in which a lipid-soluble reaction product is formed by catalyzing an addition reaction of two or more kinds of substrates, characterized by comprising a labeling step in which any one of the substrates is labeled, a reaction step in which an enzymatic reaction is carried out in the presence of an enzyme, all substrates and an acceptor, and a detection step in which the reaction product is detected by bringing the labeled molecule and a molecule to be detected close to each other via the acceptor and transferring an energy generated by the labeled molecule to the molecule to be detected, and a method of evaluating a compound utilizing the method of measuring an activity. By the methods of the invention, it is possible to perform a treatment from the enzymatic reaction to the measurement of an enzyme activity with the simple steps and it is possible to provide a method of measuring an enzyme activity which can be applied to an HTS evaluation system. | 2009-01-22 |
20090023164 | COMPOSITIONS AND METHODS FOR THE DETECTION OF HIV-1/HIV-2 INFECTION - This invention relates to compositions and methods or the detection of immunodeficiency virus infection, especially immunodeficiency virus-1 (HIV-1) infection. The invention particularly concerns compositions and methods that may be used in HIV vaccine recipients whose sera may contain vaccine-generated anti-HIV-1 antibodies. | 2009-01-22 |
20090023165 | Methods for Early Diagnosis of Kidney Disease - The invention provides reagents and methods for diagnosing kidney disease in a human or animal. | 2009-01-22 |
20090023166 | Method For the in Vitro Diagnosis of Autoimmune Immune Response by Detection of Antibodies Directed Against The Pentraxin 3 Antigen - A method for the in vitro diagnosis of an autoimmune immune response in an individual by detection, in a biological fluid from said individual, of antibodies directed against the pentraxin 3 (PTX3) antigen, characterized in that the presence of antibodies directed against the PTX3 antigen (anti-PTX3 antibodies) are determined in a biological fluid from the individual, and kits for implementing the method. | 2009-01-22 |
20090023167 | METHOD, REAGENT AND KIT FOR DETERMINATION OF CHOLESTEROL IN REMNANT-LIKE PARTICLES (RLP) - The present invention provides a method, a reagent and a kit for simple and sensitive determination of cholesterol in remnant-like particles without separation of components of a sample. A method for quantitatively determining remnant-like particle cholesterol in a sample, which comprises: in an aqueous medium containing the sample and in the presence of a combination of specific surfactants and a phospholipid-hydrolyzing enzyme, allowing remnant-like particle cholesterol in the sample to react with cholesterol esterase and cholesterol oxidase or cholesterol dehydrogenase (in the presence of oxidized coenzyme); and determining the formed hydrogen peroxide or reduced coenzyme. | 2009-01-22 |
20090023168 | Method of screening placental proteins responsible for pathophysiology of preeclampsia, and marker for early diagnosis and prediction of preeclampsia - The present invention relates to a method of screening placental proteins responsible for pathophysiology of preeclampsia, and a marker for early diagnosis and prediction of preeclampsia. In accordance with one aspect of the present invention, there is provided a method of screening placental proteins responsible for pathophysiology of preeclampsia by 2D E-proteomics analysis, comprising: isolating placental proteins from a placental tissue; separating the isolated proteins two-dimensionally through 2D electrophoresis; and comparing and analyzing the separated proteins based on scanned gel images and differences in the images between normal placental proteins and preeclamptic placental proteins, wherein the comparison and analysis of the placental proteins based on the scanned gel images and differences in the images are accomplished by selecting proteins with differences of 140% or more between two placentas. | 2009-01-22 |
20090023169 | High throughput sarcomeric assay - The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts. | 2009-01-22 |
20090023170 | Methods And Kits For The Detection of Biotoxic and Antibiotic Residues - The invention provides a kit for the detection of antibiotic residues comprising inducible bacterial spores which produce an induced enzyme after germination and induction; a germinant that triggers rapid germination of said spores; an inducer that triggers the production of the specific enzyme of interest; a substrate upon which said enzyme acts; and a detector of the activity of said enzyme on said substrate. | 2009-01-22 |
20090023171 | Method for determining specific groups constituting heparins or low molecular weight heparins - The invention provides methods for analysing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quaternary ammonium salt. The methods of the invention may be used to analyse samples without pre-treatment or to analyse samples that have been partially or exhaustively depolymerised and, optionally, reduced. Specific saccharides can be detected. | 2009-01-22 |
20090023172 | GTP Cyclohydrolase II as a Target for Fungicides - The present invention relates to the identification of fungal GTP cyclohydrolase II as a target for fungicides, to a method for identifying antifungal agents based on fungal GTP cyclohydrolase II, and also to the use of compounds identified as fungicides via the abovementioned method. | 2009-01-22 |
20090023173 | Luminescence-based methods and probes for measuring cytochrome P450 activity - The invention provides compounds, compositions, methods, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step methods using luminogenic molecules, e.g. luciferins or coelenterazines, that are cytochrome P450 substrates and that are also bioluminescent enzyme, e.g., luciferase, pro-substrates are provided. The present method further provides a method for stabilizing and prolonging the luminescent signal in a luciferase-based assay using luciferase stabilizing agents such as reversible luciferase inhibitors. | 2009-01-22 |
20090023174 | METHODS AND COMPOSITIONS FOR DETECTING IMMUNE RESPONSES - Methods and compositions for detecting immune responses and antigen-specific cells are described herein. | 2009-01-22 |
20090023175 | Device for sampling a fluid and detecting an analyte therein - Provided is a device for detecting an analyte in a fluid comprising a first compartment ( | 2009-01-22 |
20090023176 | Devices, systems and methods for isometric and isotonic contraction of blood vessels using an isovolumetric myograph - The present invention discloses devices, systems and methods for the isovolumic measurement of vasoactivity in a blood vessel ( | 2009-01-22 |
20090023177 | ASSAYS AND METHODS FOR DETERMINING STIM2 ACTIVITY - The present invention provides assays and methods for determining levels of STIM2 activity, thus providing tools for the characterization and study of the regulation of intracellular calcium levels. | 2009-01-22 |
20090023178 | Parkin Substrate and Assay - The invention provides in vitro, ex vivo, and in vivo assays for Parkin activity, in which Parkin-mediated ubiquitination of a Sept4 protein is measured. The assays may be used to screen for agents that modulate Parkin protein ligase activity. | 2009-01-22 |
20090023179 | Reagent, Medium, and Method for Detection of Alicyclobacilus Acidoterrestris - To supply the reagent, medium, and method for detection of | 2009-01-22 |
20090023180 | Reduction of Shading in Microalgae - Methods provided herein are directed to increasing the efficiency of light utilization of photosynthetic microorganisms. Also provided are screening assays, genetic constructs, and photosynthetic microorganisms for increasing light utilization efficiency and production of molecules such as ATP, oxygen, hydrogen, and recombinant proteins. Methods provided herein can be performed with any photosynthetic microorganism, including prokaryotic and eukaryotic microorganisms. | 2009-01-22 |
20090023181 | Method and Device for Detection of Erythromycin-Induced Clindamycin Resistance - A device and method are provided for determination of erythromycin-induced clindamycin resistance. The device is preferably a test panel containing one or more wells each having a known concentration(s) of erythromycin and known concentration(s) of clindamycin. After inoculation of the wells with a sample and incubation, the wells are analyzed for growth and to determine whether sample contains a microorganism that expresses erythromycin-induced clindamycin resistance. | 2009-01-22 |
20090023182 | COMPLEMENTARY METABOLIZING ORGANISMS AND METHODS OF MAKING SAME - The invention provides a non-naturally occurring set of microbial organisms. The set of organisms includes: at least a first constituent complementary metabolizing organism (CMO) exhibiting the ability to metabolize a first carbon substrate and having substantially impaired metabolic capacity for a second carbon substrate, and at least a second constituent complementary metabolizing organism (CMO) exhibiting the ability to metabolize the second carbon substrate and having substantially impaired metabolic capacity for the first carbon substrate, wherein a co-culture of the at least first and second CMOs exhibit simultaneous metabolism of a mixture having the first and second carbon substrates compared to either CMO alone. Simultaneous metabolism of a mixture having first and second carbon substrates can include an enhanced rate of metabolism of the first and second substrates compared to either CMO alone. Also provided is a bioprocess for producing a chemical compound. The bioprocess includes co-culturing a non-naturally occurring set of microbial organisms in a mixture having at least a first and a second carbon substrate under conditions sufficient for biosynthesis of a target chemical compound, the set of non-naturally occurring microbial organisms including: at least a first constituent complementary metabolizing organism (CMO) exhibiting the ability to metabolize the first carbon substrate and having substantially impaired metabolic capacity for the second carbon substrate, and at least a second constituent complementary metabolizing organism (CMO) exhibiting the ability to metabolize the second carbon substrate and having substantially impaired metabolic capacity for the first carbon substrate, wherein a co-culture of the at least first and second CMOs exhibit simultaneous metabolism of a mixture having the first and second carbon substrates compared to either CMO alone. Simultaneous metabolism of a mixture having first and second carbon substrates can include an enhanced rate of metabolism of the first and second substrates compared to either CMO alone. | 2009-01-22 |
20090023183 | Method For Preparing Recombinant Peptide From Spider Venom and Analgesic Composition Containing The Peptide - The present invention relates to a method for producing a recombinant, spider toxin peptide and analgesic compositions containing said peptide. More specifically, the present invention relates to a method in which the gene for GsMTx4 is subcloned into a vector, so that it is linked to a secretion signal sequence of the alpha factor and under the control of methanol-inducible alcohol oxidase (AOX) promoter to construct a recombinant yeast expression plasmid. Yeast cells are transformed with this plasmid to produce the GsMTx4 peptide and analgesic compositions containing said peptide. The recombinant yeast expression system of the present invention affords a more stable method for producing GsMTx4 than its natural route. Thus the GsMTx4 peptide and its derivatives produced by the method of this invention can be used in the cure of related diseases such as heart failure as the peptide specifically inhibits mechanosensitive ion channels. | 2009-01-22 |
20090023184 | Novel Tachykinin Peptides, Precursor Peptides Thereof And Genes Encoding The Same - Tachykinin peptide isolated and purified from the posterior salivary gland | 2009-01-22 |
20090023185 | Avidin Mutants - Two circularly permuted avidin monomers are designed. The circularly permuted monomers (cpAvd5→4 and cpAvd6→5) are fused and the resulting fusion peptides (dcAvd) form a pseudo-tetrameric dual-chain avidin, which is biologically active in biotin binding and shows similar structural characteristics as wild-type avidin. The dcAvd makes the development of dual-affinity avidins possible by allowing the adjustment of the ligand binding properties in the half of the binding sites differently than in the rest of the sites. The present invention provides further a single-chain avidin (scAvd) where two dcAvd-molecules are fused together via a linker to form a single polypeptide with four binding sites for biotin. | 2009-01-22 |
20090023186 | USE OF VALPROIC ACID FOR ENHANCING PRODUCTION OF RECOMBINANT PROTEINS IN MAMMALIAN CELLS - Culturing cells for the commercial production of proteins for diagnosis and therapy is a costly and time consuming process. The equipment required is expensive, and production cost are high. In order to provide commercially viable processes it is desirable to use cell lines which produce large quantities of product with each production run. However, most cells do not produce large quantities of desired product per se either because they do not produce a large quantity of product per unit of time (specific productivity) or because they do not survive long enough in the culture medium (time). Here, we identified that addition of a valproic acid compound to the culture medium increases overall (batch) yield and titer. More importantly, compared to the widely used sodium butyrate, batch yields using a valproic acid compound as a medium additive are significantly higher. | 2009-01-22 |
20090023187 | Method of obtaining a product sugar stream from cellulosic biomass - A process for obtaining a product sugar stream from cellulosic biomass is disclosed. In one process, the cellulosic biomass is pretreated at a pH between about 0.4 to 2.0 by adding one or more than one acid to produce a pretreated cellulosic biomass comprising acetic acid. One or more than one base is then added to the pretreated cellulosic biomass to adjust the pretreated cellulosic biomass to a pH of about 4.0 to about 6.0 to produce a neutralized cellulosic biomass comprising inorganic salt and acetate salt. The neutralized biomass is then hydrolyzed by cellulase enzymes to produce a crude sugar stream. Insoluble residue is separated from the crude sugar stream and the resulting clarified sugar stream is treated using ion exclusion chromatography at about pH 5.0 to about 10.0 to produce one or more raffinate streams and a product stream. The raffinate stream comprises inorganic salts and acetate salts, and the product stream comprises sugar. The product stream may then be fermented or otherwise further processed. In an alternate process, a product sugar stream is obtained from a crude sugar stream that is produced from conversion of cellulosic biomass to sugar. The cellulosic biomass may be produced using any suitable method. In this process the crude sugar stream is treated using ion exclusion chromatography at about pH 5.0 to about 10.0 to produce one or more than one raffinate stream comprising sulfate and acetate salts, and a product stream comprising sugar, and the product sugar stream is obtained. | 2009-01-22 |
20090023188 | Heparin/heparosan synthase from P. multocida and methods of making and using same - The presently claimed and disclosed invention relates, in general, to dual action heparin synthases and, more particularly, to dual action heparin synthases obtained from | 2009-01-22 |
20090023189 | APPARATUS AND METHODS FOR PREPARATION OF SUBTANTIALLY UNIFORM EMULSIONS CONTAINING A PARTICLE - Methods and systems for forming water-in-oil emulsions are described. For example, an apparatus is described which includes: a first compartment containing a plurality of particles dispersed in an aqueous phase; a second compartment containing an oil phase; a porous layer separating the first and second compartments; and a device for applying pressure to the first compartment. A method is described which includes: moving an oil phase relative to a surface of a porous layer while simultaneously forcing an aqueous composition comprising particles through the porous layer and into the flowing dispersion medium thereby forming droplets of the aqueous composition containing particles dispersed in the oil phase. The aqueous composition can include one or more nucleic acid templates and reagents for amplifying the nucleic acids such as PCR reagents. A porous partition is described comprising a first and second major surfaces and at least two straight through pores comprising a cross sectional shape selected from a polygon, an oval, an oblong, a dumbbell, a bowtie and irregular shapes thereof. Aqueous droplets containing an oligonucleotide attached to a particle and reagents can be used as a microreactor for nucleic acid amplification. | 2009-01-22 |
20090023190 | SEQUENCE AMPLIFICATION WITH LOOPABLE PRIMERS - The present disclosure relates to the amplification of target nucleic acid sequences. This can be accomplished via the use of various primers. The use of these primers, as described herein, results in nucleic acid structures that can reduce the amplification of nonspecific hybridization events (such as primer dimerization) while allowing the amplification of the target nucleic acid sequences. | 2009-01-22 |
20090023191 | Gene RCS 23 - The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 2009-01-22 |
20090023192 | Process for Producing Ethanol - A process for producing ethanol including a combination of biochemical and synthetic conversions results in high yield ethanol production with concurrent production of high value coproducts. An acetic acid intermediate is produced from carbohydrates, such as corn, using enzymatic milling and fermentation steps, followed by conversion of the acetic acid into ethanol using esterification and hydrogenation reactions. Coproducts can include corn oil, and high protein animal feed containing the biomass produced in the fermentation. | 2009-01-22 |
20090023193 | ANAEROBIC REACTOR AND CORRESPONDING METHOD FOR DIGESTING ORGANIC MATERIAL - The present invention is an anaerobic reactor and preferably a vertically oriented plug flow anaerobic reactor for producing methane from various organic materials. The organic materials preferably have a high organic content. The reactor includes cutting members for cutting bridged or agglomerated material within the reactor. The present invention also includes a process for producing methane from an organic feed stock by continuously charging an organic material into the top portion of a vertically oriented vessel and rotating one or more cutting members at a sufficiently slow rate so that the cutting members cut through bridged or agglomerated material but do not substantially mix contents within the reactor, anaerobically digesting the organic material under mesophilic or thermophilic conditions to produce methane while allowing the organic material to propagate downward through the vessel in a plug flow-like manner and collecting methane gas produced from the anaerobic digestion of the organic material. | 2009-01-22 |
20090023194 | DEVICE AND METHOD FOR THE CULTIVATION AND GENERATION OF BIOLOGICAL MATERIAL IN A NUTRIENT MIST - The present invention relates to a device and a method for the cultivation and generation of biological material. | 2009-01-22 |
20090023195 | Bio-based method for making mannitol - Mannitol is produced in a highly efficient fermentative method using | 2009-01-22 |
20090023196 | Stocks of replication-deficient adenovirus - Presented are ways to address the problem of replication-competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with a selected vector are suited for large scale production of recombinant adenoviruses. A system for use with the invention produces replication-defective adenovirus. The system includes a primary cell containing a nucleic acid based on or derived from adenovirus and an isolated recombinant nucleic acid molecule for transfer into the primary cell. The isolated recombinant nucleic acid molecule is based on or derived from an adenovirus, has at least one functional encapsidation signal and at least one functional Inverted Terminal Repeat, and lacks overlapping sequences with the nucleic acid of the cell. Otherwise, the overlapping sequences would enable homologous recombination leading to replication-competent adenovirus in the primary cell into which the isolated recombinant nucleic acid molecule is to be transferred. | 2009-01-22 |
20090023197 | Method for purifying a viral suspension - The invention relates to a method for obtaining viruses from a liquid viral suspension, according to which:
| 2009-01-22 |
20090023198 | OPTIMIZING EXPRESSION OF ACTIVE BOTULINUM TOXIN TYPE A - Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/A in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/A from such nucleic acid molecules, expression constructs and cells. | 2009-01-22 |
20090023199 | MICRO-ORGANISM PRODUCTION SYSTEM AND METHOD - A micro-organism production system having at least one micro-organism growth unit for maintaining therein micro-organisms in solution. Upon the receipt of a predetermined amount of live organisms, liquid and nutrients within the at least one micro-organism growth unit and the application of radiation thereto, the system produces the rapid growth of micro-organisms within the at least one micro-organism growth unit. | 2009-01-22 |
20090023200 | PARTICLE FOR DETECTING ENZYME ACTIVITY, METHOD FOR DETECTING THE ENZYME ACTIVITY AND ENZYME ACTIVITY DETECTION DEVICE BY THE USE THEREOF - An object is to provide a particle for detecting an enzyme activity wherein by measuring an intensity of a fluorescence wavelength in a sample solution, it is possible to not only detect the presence or absence of an enzyme but also accurately perform a quantitative analysis of the enzyme in the sample solution, handleability is excellent as well as measurement accuracy and quantitative property can be enhanced because the present invention is hardly influenced by absorbed moisture and weighing errors hardly occur, and further productivity is remarkably excellent because complicated steps such as a step of cleaving and purifying a synthesized peptide and a step of lyophilizing are not required upon production thereof. | 2009-01-22 |
20090023201 | NUCLEIC ACID DETECTING CASSETTE AND NUCLEIC ACID DETECTING APPARATUS - In a nucleic acid detecting cassette in which a heating treatment chamber and a liquid delivery channel are constituted of a stationary member and flexible members, the heating treatment chamber is held by convex heating sections from both sides, whereby the heat treatment chamber and the liquid delivery channel are spatially separated from each other. Thus, it is possible to automatically execute a consistent process including nucleic acid amplification and other required treatments of the object sample as well as detection of a target nucleic acid. | 2009-01-22 |
20090023202 | NUCLEIC ACID ANALYSIS DEVICE AND NUCLEIC ACID ANALYZER USING THE SAME - The present invention relates to a nucleic acid analysis device for analysis of nucleic acid in a sample through fluorometry, in which a localized surface plasmon by light irradiation, and in which a nucleic acid probe or a nucleic acid synthase for the analysis of the nucleic acid in the sample is disposed in a region of generation of the surface plasmon. The present invention allows the fluorescence intensifying effect of the surface plasmon to be produced efficiently and also enables the immobilization of a DNA probe or the nucleic acid synthase in a region on which the fluorescence intensifying effect is exerted, thus making it possible to carry out a measurement on the base elongation reaction without having to remove the unreacted substrate with the fluorescent molecule. | 2009-01-22 |
20090023203 | Sensor Device for Interrogation of Changes in the Contents of a Sealed Container - A device and method allowing evaluation of the contents of a sealed primary container by means of an integral sensor which is separated from the contents of the sealed primary container yet provides information on quality of the contents of the primary container without breaking the sealed system. The integral sensor device includes a biosensor retained within a plastic construct by a gated-pore membrane. Pores in the membrane open in response to an environmental change in the primary container allowing the contents of the primary container to contact the biosensor. Status of the contents of the primary container can be determined by inspection of the biosensor, visually or via a fiberoptic probe, through the optical window of the plastic construct. | 2009-01-22 |
20090023204 | A Device for the Storage and Treatment of Biodegradable Wet Solid Waste - The present invention relates to a device for the storage and treatment of biodegradable wet solid waste, especially for vegetarian household waste materials. The device consists of a bucket shaped container with a mesh bottom and a removable cover with a hole at the center. The container is provided with a leachate collection basket at the bottom, which is mounted on an iron stand to hold the device. Openings are provided on the lateral surface of the basket for ventilation. The waste is added to the container from the top by hand lifting the lid. The ventilation facilitates degradation of the material in side the container, reducing the release of odour and, leachate. The volume of the waste also gets reduced because of self-compaction. In one embodiment the storage and treatment device is provided in the form of a house hold kit. | 2009-01-22 |
20090023205 | Method for the separation of living cells - The present in invention relates to a method for the separation of living cells from a mixture of dead and living cells which optionally can also possibly contain cell fragments. | 2009-01-22 |
20090023206 | MICROINJECTION APPARATUS AND METHOD OF INJECTING FLUID - A microinjection apparatus allows a capillary to stick into an object. A discharge pressure is supplied to the capillary. The supplied discharge pressure allows the discharge of a first fluid from the tip end of the capillary. The first fluid is injected into the object. The remains of the object possibly adhere to the tip end of the capillary. A pipe member defines a flow passage for a second fluid directed toward the tip end of the capillary. The second fluid thus flows toward the tip end of the capillary. The second fluid allows the removal of the remains from the tip end of the capillary. The mentioned action of removing the remains does not interrupt the injection of the first fluid into the object. The injection of the first fluid is continuously applied to the objects with efficiency. | 2009-01-22 |
20090023207 | CHROMOSOME 3p21.3 GENES ARE TUMOR SUPPRESSORS - Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3. | 2009-01-22 |
20090023208 | Cultivation of Primate Embryonic Cells - The invention relates to methods for culturing human embryonic stem cells by culturing the stem cells in an environment essentially free of mammalian fetal serum and in a stem cell culture medium including amino acids, vitamins, salts, minerals, transferring, insulin, albumin, and a fibroblast growth factor that is supplied from a source other than just a feeder layer the medium. Also disclosed are compositions capable of supporting the culture and proliferation of human embryonic stem cells without the need for feeder cells or for exposure of the medium to feeder cells. | 2009-01-22 |
20090023209 | SOLUTION FOR THE INDEFINITE MAINTENANCE OF NUCLEIC ACIDS IN THE CELL OF ORIGIN THEREOF - The invention relates to a product having characteristics which enable a biological sample obtained from an individual to be maintained under conditions such that the quality of nucleic acids later extracted is not affected, thereby guaranteeing the integrity of the sample regardless of the time that elapses between the sample being obtained and the nucleic acid being extracted. A solid (organic) or liquid (blood, semen, cell culture) biological sample from a eukaryote or prokaryote is mixed in a solution comprised of a mixture of trisodium ethylenediaminetetraacetic acid (EDTA), sodium fluoride (NaF), and saturation with thymol (extracted from | 2009-01-22 |
20090023210 | B-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST ANTHRAX LETHAL TOXIN - The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of β-cyclodextrin. Per-substituted alkylamino derivatives displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition of one of the alkylamino derivatives to the bilayer lipid membrane with multiple PA channels caused a significant decrease in membrane conductance. Thus, the invention also provides methods for protection against anthrax toxicity. | 2009-01-22 |
20090023211 | Blood platelet lysate and method of producing the same - A method of preparing a blood platelet lysate starting from platelet-rich plasma from whole blood of animals, to which blood a citrate has been added to prevent coagulation, is described. The method is characterised by concentrating the platelet-rich plasma by ultrafiltration to obtain a plasma that is richer in platelets, adding water for lysis of the platelets included, adding Ca | 2009-01-22 |
20090023212 | Method for transforming soybean (Glycine max) - The present disclosure provides methods for the transformation of soybean cells or tissue and regeneration of the soybean cells or tissue into transformed plants. The disclosed methods utilize an explant prepared from an immature soybean inflorescence, shoot apex, leaf axillary, shoot axillary, or combination thereof which can be induced directly to form shoots that give rise to transgenic plants via organogenesis. | 2009-01-22 |
20090023213 | Method to increase the rate of transgenic embryo formation after inoculation of immature cotyledons with agrobacterium - The present disclosure provides methods for the transformation of soybean cells or tissue and regeneration of the soybean cells or tissue into transformed plants. The disclosed methods utilize an explant prepared from an immature soybean cotyledon which can be induced directly to form shoots that give rise to transgenic plants via embryogenesis. | 2009-01-22 |
20090023214 | Rescue of Plant Cell Cultures and Suspensions After Cryopreservation-Induced Damage - The subject invention relates to recovery of cryopreserved plant cell cultures after cryopreservation. The use of canine IL-4 and human gamma interferon is exemplified in some preferred embodiments. | 2009-01-22 |
20090023215 | Novel reagents for transfection of eukaryotic cells - Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes. | 2009-01-22 |
20090023216 | Double-Stranded Oligonucleotides - Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions. | 2009-01-22 |