| 03rd week of 2009 patent applcation highlights part 41 |
| Patent application number | Title | Published |
|---|
| 20090017441 | ASYMMETRIC CYANINE FLUORESCENT DYES - The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R | 2009-01-15 |
| 20090017442 | In-vitro diagnostic medical devices for determining saliva volume - The invention relates to a method of collecting saliva from the oral cavity for detecting a test substance, comprising the steps of (a) cleaning the oral cavity, (b) stimulating saliva secretion with a saliva-collecting solution, (c) removing the saliva-saliva collecting solution mixture from the oral cavity and collecting it in a container ( | 2009-01-15 |
| 20090017443 | Method for Detection of Hepatitus B Virus - To provide a method for detection or quantification of hepatitis B virus (HBV) antigens in serum and a simple and highly user-friendly method for sample treatment for use in the detection or quantification thereof. The method for treatment of a sample containing hepatitis B virus (HBV) is characterized in that release of HBV antigens and disruption of antibodies that bind to HBV antigens are carried out by treating a sample containing HBV with a treatment agent containing (1) an acidifying agent and (2) a protein denaturant or an amphoteric surfactant or cationic surfactant having an alkyl group and a tertiary amine or a quaternary ammonium salt within a molecule. | 2009-01-15 |
| 20090017444 | Screening method for modulators of viral transcription or replication - The invention provides methods to identify modulators of viral transcription or replication. | 2009-01-15 |
| 20090017445 | Method For Detecting And Removing Endotoxin - The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca | 2009-01-15 |
| 20090017446 | Method and Set of Tools for Checking the Crystallisation Conditions of Biological Macromolecules - The invention relates to a method and set of tools for checking and ascertaining the crystallisation conditions of biological macromolecules using the counter-diffusion technique which employs precipitating agents, additives and buffers. The concentration of the precipitating agent(s) in the medium (solution or gel) is greater than those currently used with other available checking techniques, such as batch, microbatch or vapour phase diffusion techniques, such that, as a result of the diffusion along the length of the capillary containing the biological macromolecule, a large number of concentrations of the precipitating agent(s) used in one experiment are checked. The set of tools or kit contains the necessary elements for performing said method. | 2009-01-15 |
| 20090017447 | Human Endogenous Retrovirus with Foamy-Like Properties and Uses Thereof - The invention relates to the discovery of a human endogenous retrovirus (HERV) family, Type I HERV-K (HML-2) which appear to be active in vitro and in vivo, infectious, and which have the have the salient features and properties of foamy retroviruses. Based on its natural replication in humans, and that it protects the host from viral and tumor transformation, this non-pathogenic endogenous virus could be developed as a replication competent gene therapy vector. It also is expected to have much higher efficacy than other vectors as it crosses the bloodbrain barrier and infects almost all cell types in the host (proliferating or not). It may naturally lyse tumor cells or infected cells, and thus could even be used without genetic modification. Of course, this vector could be used in traditional ways with it ability to replicate genetically removed. In addition to its value as a vector, as it is reactivated with infection, its detection could also be used to monitor the safety of gene therapy (irrespective of vector type used), as well as other biological therapies including vaccination, blood transfusion, transplantation and xenotransplantation. Finally it may be used to screen for new therapeutic and prophylactic treatments for a wide variety of diseases. | 2009-01-15 |
| 20090017448 | SCREENING TOOL FOR ANTIVIRAL AGENTS - A method is provided for screening anti-adenovirus agents. The method includes reducing the activation of the immune system of a small mammal, administering a human adenovirus vector to the small mammal, monitoring the tumor cells in the mammal, and analyzing infectious virus units within the tumor cells and the organs of the small mammal. Specifically, the immune system of the small mammal is suppressed using cyclophosphamide. The small mammal may be, but is not limited to, one of the following: mice, rabbits, cotton rats, hamsters, rats, and other small rodents. | 2009-01-15 |
| 20090017449 | COMPOUNDS AND METHODS FOR ASSAYING FUSION OF AN INDIVIDUAL, ENVELOPED VIRUS WITH TARGET MEMBRANE - Compositions and methods for monitoring viral fusion are provided. Methods of labelling virions are also provided. A novel, detectable label is provided. A mobile lipid bilayer is also provided. | 2009-01-15 |
| 20090017450 | Primer for detection of human papillomavirus - Disclosed are primers specific to the genome of HPV genotypes 11, 16, 18 and 31. Also disclosed are a kit for detecting the HPV genome comprising the primers and a method of detecting the HPV genome using the primers. | 2009-01-15 |
| 20090017451 | Generation of Recombinant Genes in Saccharomyces Cerevisiae - The present invention relates to methods for generating and detecting recombinant DNA sequences in | 2009-01-15 |
| 20090017452 | METHODS AND COMPOSITIONS RELATING TO THE PHARMACOGENETICS OF DIFFERENT GENE VARIANTS - The present invention is directed to methods and compositions for determining the presence or absence of polymorphisms within an ABCC2, UGT1A1, and/or SLCO1B1 gene and correlating these polymorphisms with activity levels of their gene products and making evaluations regarding the effect on their substrates, particularly those substrates that are drugs. In addition, there are methods and compositions of evaluating the risk of an individual for developing toxicity or adverse event(s) to an ABCC2, UGT1A1, and/or SLCO1B1 substrate. In some embodiments, the invention concerns methods and compositions for determining the presence or absence of ABCC2 3972C>T variant and predicting or anticipating the level of activity of ABCC2 and determining dosages of an ABCC2 drug substrate, such as irinotecan, in a patient. Such methods and compositions can be used to evaluate whether irinotecan-based therapy, or therapy involving other ABCC2 substrates, may pose toxicity problems if given to a particular patient or predicting their efficacy. Alterations in suggested therapy may ensue based on genotyping results. | 2009-01-15 |
| 20090017453 | NICKING AND EXTENSION AMPLIFICATION REACTION FOR THE EXPONENTIAL AMPLIFICATION OF NUCLEIC ACIDS - The invention is in general directed to the rapid exponential amplification of short DNA or RNA sequences at a constant temperature. | 2009-01-15 |
| 20090017454 | BIOSENSORS, METHOD FOR OBTAINING THE SAME AND USES THEREOF - The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of the active site is naturally present in the form of a cystein (Cys) residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue. | 2009-01-15 |
| 20090017455 | Methods and systems for detecting and/or sorting targets - Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded-protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate. | 2009-01-15 |
| 20090017456 | DETECTION, IDENTIFICATION AND DIFFERENTIATION OF EUBACTERIAL TAXA USING A HYBRIDIZATION ASSAY - The present invention relates to a method for the specific detection and/or identification of | 2009-01-15 |
| 20090017457 | IDENTIFICATION OF MODULATORS OF SERINE PROTEASE INHIBITOR KAZAL AND THEIR USE AS ANTI-CANCER AND ANTI-VIRAL AGENTS - This invention describes a relevant etiology of cancer and a novel anti-cancer therapeutic strategy, based on the discovery that a protein named serine protease inhibitor (SPIK/SPINK/PSTI) was up-regulated by hepatitis B and C virus infections consequently suppressing the cell apoptosis. Accordingly, this invention provides an inhibitor of SPIK and/or a technology of suppression of over-expression of SPIK in cells. The inhibitors include: 1) chemical compounds, which can inhibit SPIK transcripts, protein activity, and gene expression, 2) SPIK siRNA (RNAi gene silence or dsRNA of SPIK, 3) DNA anti-sense and anti-SPIK antibody. Further, this invention provides a method of using the inhibitor as an anti-cancer agent to re-instate cancer cell apoptosis (e.g., serine protease dependent cell apoptosis). | 2009-01-15 |
| 20090017458 | DISEASE DIAGNOSIS APPARATUS AND METHOD USING PHOTOCURRENT OF AMORPHOUS SILICON - Provided is a disease diagnosis apparatus and method for detecting a specific disease. The disease diagnosis chip, includes: a light sensing layer; a probe molecule fixed on the light sensing layer; and an electrode connected to the light sensing layer to detect an electric signal corresponding to photoelectric charges of the light sensing layer. | 2009-01-15 |
| 20090017459 | MEASURING ANALYTES USING COMPETITIVE INTERFERENCE AND RECUPERATION OF ENZYME ACTIVITY - The present teaching generally discloses a method of measuring the concentration of an analyte in a solution. The method includes selecting a binding compound; selecting an analog to an analyte and conjugating the analog to a polynucleotide substrate to construct a reagent for measuring the amount of the analyte in an assay solution using a desired polynucleotide reaction that comprises a polymerization reaction, a cleavage reaction, or a recombination reaction. The binding of the reagent to the binding compound in the assay solution competes with the binding of the analyte to the binding compound in the assay solution. The method also includes selecting a desired enzyme for catalyzing the desired polynucleotide reaction. Reagents and kits are also provided. | 2009-01-15 |
| 20090017460 | DIFFERENTIAL EXPRESSION PROFILING ANALYSIS OF CELL CULTURE PHENOTYPES AND USES THEREOF - The present invention provides, among other things, systems and methods for identifying genes and proteins that regulate and/or are indicative of cell phenotypes based on expression profiling analysis. The present invention further provides methods of manipulating identified genes and proteins to engineer improved cell lines. | 2009-01-15 |
| 20090017461 | Diagnosis of Gynecological Neoplasms by Detecting the Levels of Oviduct-Specific Glycoprotein - The present invention provides a method for detecting cancer in a patient. A sample from the patient is provided, and the level of oviduct-specific glycoprotein (OGP) in the sample is determined and compared to a control sample. Increased levels of OGP in the sample as compared to the control indicates that the patient has cancer. In one aspect, the cancer is a gynecological cancer, such as ovarian cancer. Kits for conducting the methods of the invention are also provided. | 2009-01-15 |
| 20090017462 | Recombinase polymerase amplification - This disclosure describe three related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods may allow amplification of DNA up to hundreds of megabases in length. | 2009-01-15 |
| 20090017463 | METHODS FOR PREDICTING PROSTATE CANCER RECURRENCE - The present invention relates to the identification of four cytokine biomarkers in prostatic tissue that exhibit differential expression following prostatectomy that, in combination at least one other factor, are able to reliably predict the development of biochemical recurrence following surgery. This marker combination improves the risk stratification of patients after primary local treatment for localized prostate cancer. | 2009-01-15 |
| 20090017464 | METHODS FOR DRUG DISCOVERY, DISEASE TREATMENT, AND DIAGNOSIS USING METABOLOMICS - The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed. | 2009-01-15 |
| 20090017465 | Compound Screening Using Cardiomyocytes - This invention provides populations human cells of the cardiomyocyte lineage. The cells are obtained by causing cultures of pluripotent stem cells to differentiate in vitro, and then harvesting cells with certain phenotypic features. Differentiated cells bear cell surface and morphologic markers characteristic of cardiomyocytes, and a proportion of them undergo spontaneous periodic contraction. Highly enriched populations of cardiomyocytes and their replicating precursors can be obtained, suitable for use in a variety of applications, such as drug screening and therapy for cardiac disease. | 2009-01-15 |
| 20090017466 | SEPARATION-FREE ASSAY METHOD - This invention relates to a separation-free assay method employing a binding partner label and a nonspecifically binding label, wherein a signal from said binding partner label or said nonspecifically binding label is measured in a binding event, said method comprising the use of a) two or more binding partners, and a directly luminescent binding partner label adsorbed and/or covalently coupled to at least one of said binding partners; and b) said nonspecifically binding label, wherein i) said nonspecifically binding label is able to affect the signal of said binding partner label, or ii) said binding partner label is able to affect the signal of said nonspecifically binding label; and wherein at least one of said binding partners is a mobile binding partner and at least one other of said binding partners is a labeled ligand. | 2009-01-15 |
| 20090017467 | COMPOSITION EXHIBITING A VON WILLEBRAND FACTOR (vWF) PROTEASE ACTIVITY COMPRISING A POLYPEPTIDE CHAIN WITH THE AMINO ACID SEQUENCE AAGGILHLELLV - The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production. | 2009-01-15 |
| 20090017468 | METHOD OF SCREENING COMPOUND DIRECTLY ACTIVATING GLYCOGEN SYNTHASE - The present invention provides a therapeutic agent for diabetes comprising a compound directly activating glycogen synthase as an active ingredient. The present invention further provides a method for screening compounds directly activating glycogen synthase. | 2009-01-15 |
| 20090017469 | Use of Holographic Sensor - The present invention relates to a process for the detection of an analyte in a sample, comprising a) bringing the sample into contact with a first ligand which binds specifically to the analyte and which is immobilised on a substrate, and b) prior to or subsequent to step (a), bringing the sample into contact with a second ligand which binds specifically to the analyte and which includes a label: wherein the substrate comprises a holographic sensor comprising a support medium having a hologram disposed therein or thereon and the label causes an optical property of the sensor to change by interaction of the sensor with the label or, following the additional step of contacting the substrate with a reagent, by interaction of the sensor with a species produced by reaction of the label with the reagent, thereby indicating the presence of bound analyte. | 2009-01-15 |
| 20090017470 | Immunological analytical reagent for the determination of advance glycosylation end products (AGEs) - The invention provides a reagent for determination of Advance Glycosylation End Products (AGEs), comprising a suspension disposed with displaying carrier and the antigen or antibody immobilized on the surface of the said displaying carrier; and a test strip, comprising of: a base plate, and constitutive parts provided on said base plate, said constitutive parts consisting of a water absorption pad for the sample, a porous fiber membrane, a displaying carrier fiber block and at least one immobilized substance. After infusing the said reagent into the said test strip, the immunological reaction of the AGEs antigen or antibody can be determined based on the agglutination phenomenon or accompanied changes of absorbance or color and the presence or raised level of the AGEs in the diabetic patient can be known accordingly such that the practitioner can prevent the occurrence of the complicated condition, or block further the progression of the complications at the earlier stage. | 2009-01-15 |
| 20090017471 | SOLUBLE ErbB3 METHOD OF DETECTION - The present invention discloses a method using human soluble ErbB3, for example p85-sErbB3, as a negative regulator of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention also discloses p85-sErbB3 binding to heregulin with an affinity comparable to that of full-length ErbB3, and competitively inhibiting high affinity heregulin binding to ErbB2/ErbB3 heterodimers on the cell surface of breast carcinoma cells. The present invention also uses p85-sErbB3 to inhibit heregulin-induced phosphorylation of ErbB2, ErbB3, and ErbB4 in cells, as a negative regulator of heregulin-stimulated signal transduction, and as a block for cell growth. The present invention is also directed to nucleic acids and expression vectors encoding p85-sErbB3, host cells harboring such expression vectors, and methods of producing the protein. The present invention discloses a method of therapeutically treating human malignancies associated with heregulin-mediated cell growth such as breast and prostate cancer. | 2009-01-15 |
| 20090017472 | BIOMARKERS PREDICTIVE OF THE RESPONSIVENESS TO TNFalpha INHIBITORS IN AUTOIMMUNE DISORDERS - The invention provides methods for predicting responsiveness to TNFα inhibitors in a subject suffering from an autoimmune disorder, such as rheumatoid arthritis. The methods involve assaying for expression of one or more biomarkers in the subject that are predictive of responsiveness to TNFα inhibitors. A preferred biomarker of the invention is CD11c. The methods can further comprise selecting a treatment regimen with a TNFα inhibitor in an autoimmune disorder subject based upon expression of the biomarker(s) in the subject. The methods can further comprise administering a TNFα inhibitor to the subject according to the selected treatment regimen. Kits that include means for measuring expression of one or more biomarkers that are predictive of responsiveness to TNFα inhibitors for an autoimmune disorder are also provided. Methods of preparing and using databases, and computer program products therefore, for selecting an autoimmune disorder subject for treatment with a TNFα inhibitor are also provided. | 2009-01-15 |
| 20090017473 | Compositions and methods for the diagnosis and treatment of tumor - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. | 2009-01-15 |
| 20090017474 | SYSTEMS AND METHODS FOR DETECTING ABNORMAL CELLS - Systems and methods of interrogating clusters of cells for two or more biological markers that do not, or rarely, occur in the same cell during normal cellular growth, development and function, to indicate the existence of cells that are part of a local area where a pre-neoplastic or neoplastic lesion may be present. The relationship among cells is maintained while interrogating the clusters of cells to facilitate the examination and determination of the existence of possible dysplasia. | 2009-01-15 |
| 20090017475 | Method to Determine Pseudo-Allergic Reactions - Method and kit for determining the possible appearance of adverse reactions (such as anaphylactoid reactions) in patients in need to undergo to an administration of a pharmaceutical compound. The method for determining potential hypersensitivity in a patient to pseudo-allergic reactions comprises adding a predetermined amount of a compound with anaphylatoxic activity to a sample of the patient's blood and determining the amount of activation of the patient's basophil cells in said blood sample. The compound with anaphylatoxic activity is preferably selected from C3a, C5a, analogs of C3a or C5a, derivatives of C3a or C5a, and mixtures thereof. | 2009-01-15 |
| 20090017476 | Multiple Component Nanoparticles for Multiplexed Signaling and Optical Encoding - The present invention provides multiple-luminophore silica nanoparticles for multiplexed signaling in bioanalysis. In specific embodiments, two inorganic luminophores, Tris(2,2′-bipyridyl)osmium(II) bis(hexafluorophosphate) (OsBpy) and Tris(2,2′-bipyridyl)dichlororuthenium(II) hexahydrate (RuBpy), or three organic luminophores 5-Fluorescein isothiocyanate (5-FITC), 5-carboxyrhodamine 6G, succinimidyl ester (5-CR6G, SE), 6-carboxy-X-rhodamine, succinimidyl ester (6-ROX, SE) can be simultaneously entrapped inside silica nanoparticles at controlled ratios, with desirable sizes and required surface functionality. Single-wavelength excitation with multiple emission endows the nanoparticles with optical encoding capability for rapid and high-throughput multiplexed detection. | 2009-01-15 |
| 20090017477 | METHOD FOR DETERMINATION OF CONCENTRATION, CHARGE OR UNIT SIZE OF A SUBSTANCE - This invention relates to a method comprising the steps of a) contacting a sample containing a sample substance and a solid phase comprising a signal element, and optionally a substance containing a signal element, i.e. a signal element substance; wherein at least one of said sample substance, said solid phase, and said signal element substance comprises a signal element; wherein the surface of the solid phase contains no specific binding partners; and wherein the solid phase is capable of binding said sample substance nonspecifically, preferably through adsorption, to said solid phase, and b) detecting a signal change resulted from binding of said sample substance and/or signal element substance to said solid phase, and/or change in distance from said sample substance and/or said signal element substance to said solid phase. | 2009-01-15 |
| 20090017478 | HIGH-THROUGHPUT ENZYME-LINKED IMMUNO ABSORBENT ASSAY (ELISA) FOR DETERMINATION OF RHO-KINASE (ROK) ACTIVITY - The invention is referring to an assay for measuring the activity of a ROK (Rho Kinase) protein by means of a biotinylated peptide. | 2009-01-15 |
| 20090017479 | LY6H GENE - The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SEQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like. | 2009-01-15 |
| 20090017480 | BIOAMPLIFICATION FOR MICROBIAL SENSOR SIGNAL TRANSDUCTION - A process of detection of the causative agent of Johne's disease ( | 2009-01-15 |
| 20090017481 | Method For Identifying at Least Two Groups of Microorganisms - The present invention relates to a method for identifying at least two groups of microorganisms expressing the same enzymatic activity, comprising the following steps:
| 2009-01-15 |
| 20090017482 | Luminogenic and nonluminogenic multiplex assay - A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided. | 2009-01-15 |
| 20090017483 | Analytical instrument having improved arrangement of reagent section and analytical method - The present invention relates to an analytical instrument ( | 2009-01-15 |
| 20090017484 | MARKERS FOR ATHEROSCLEROSIS - A method for the diagnosis, prognosis or identification of a predisposition towards atherosclerosis and the susceptibility to the development of atherosclerotic plaques and/or vascular obstruction is described, the method comprising analysing a sample to determine the percentage frequency of multiple sub-populations of T-lymphocytes and comparing the data obtained against comparative and/or control data. | 2009-01-15 |
| 20090017485 | Alzheimer's Disease Examination Method - [Problems] To enable convenient and accurate examination of Alzheimer's disease. | 2009-01-15 |
| 20090017486 | METHOD AND TEST KIT FOR THE IDENTIFICATION OF COMPOUNDS SPECIFICALLY MODULATING THE ACTION OF CORTICAL AXO-AXONIC CELLS - The present invention provides a method for identifying an agent capable of specifically modulating or eliminating the action of axo-axonic cells, an experimental kit for performing the said method and compounds identifiable by the said method, as well as methods for the treatment or prevention different neurological symptoms by modulating the activity of axo-axonic cells. | 2009-01-15 |
| 20090017487 | BIOGAS PRODUCTION FROM BMR PLANTS - Methods and compositions to produce biogas and fertilizer from plant material that have reduced lignin content relative to a wild-type plant material, for example, a brown midrib (BMR) plant, are disclosed. Methane yields from BMR plants including BMR corn are significantly higher, thereby increasing the efficiency of methane production. Anaerobic digestion of plant material derived from BMR plants results in an increased methane yield. | 2009-01-15 |
| 20090017488 | Methods for Identifying Modulators of Ion Channels - The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels. | 2009-01-15 |
| 20090017489 | Methods For Modulating The Development Of Dopamine Neuron By The Dopamine D2 Receptor And Compositions Thereof - The present invention relates to a composition for modulating the activation of Nurr1, the composition comprising an agonist or an antagonist of a dopamine D2 receptor, methods for modulating the activation of Nurr1 by the dopamine D2 receptor, a method and composition for treating Nurr1-related diseases using the dopamine D2 receptor, and methods for screening a modulator of a dopamine D2 receptor of a test compound. Accordingly, the activation of Nurr1 can be modulated by treating the dopaminergic neurons with the agonist or the antagonist of the dopamine D2 receptor, thereby enhancing or inhibiting generation of the dopaminergic neurons. | 2009-01-15 |
| 20090017490 | DNA Fragment Method for Producing Transformant for Protein Production and Utilization Thereof - An expression vector is constructed by transferring recombinant tomato mosaic virus (ToMV) cDNA, in which a coat protein gene of ToMV having a suppressor against a virus resistant reaction has been substituted by a GFP gene, into the downstream of a promoter capable of inducing steroid hormone-dependent transcription. In a transformed tobacco BY-2 cell obtained by transferring the above expression vector into a tobacco BY-2 cells, steroid hormone-dependent transcription is induced, thereby enabling the amplification of mRNA of the GFP gene and induction of the expression of GFP. | 2009-01-15 |
| 20090017491 | APPARATUS AND METHOD FOR BIOLOGICAL SAMPLE PROCESSING - An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples. | 2009-01-15 |
| 20090017492 | SVPH1-26 DNA and polypeptides - DNA encoding SVPH1-26 polypeptides and methods for using the encoded proteinase and polypeptides are disclosed. SVPH1-26 is expressed in testis. | 2009-01-15 |
| 20090017493 | Gene SMS 02 - The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 2009-01-15 |
| 20090017494 | TICK OCTOPAMINE RECEPTOR NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF - The present invention relates to tick octopamine receptor nucleic acid molecules; to tick octopamine receptor proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes inhibitory compounds, particularly those that specifically inhibit tick octopamine receptor activity, as well as the use of such compounds to treat animals. | 2009-01-15 |
| 20090017495 | ESCHERICHIA COLI-DERIVED VACCINE AND THERAPY AGAINST BOTULISM - A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing | 2009-01-15 |
| 20090017496 | Co-expression of multiple protein chains or subunits - A recombinant genetic construct is provided that includes at least two expression cassettes. Each cassette encodes for a chain or subunit of a target protein. The genetic construct preferably targets any expressed protein to the secretory pathway of the host cell. An application of present invention is found in expressing the two chains of human insulin through two separate expression cassettes on the same methylotrophic yeast expression vector. Mature, bioactive human insulin molecules are secreted through this method without resorting to any post-translational cleavage process. | 2009-01-15 |
| 20090017497 | METHOD FOR MAKING INSULIN PRECURSORS AND INSULIN PRECURSOR ANALOGUES HAVING IMPROVED FERMENTATION YIELD IN YEAST - Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 Å. | 2009-01-15 |
| 20090017498 | Fibroblast Growth Factor-Like Polypeptides - The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with FGF-like polypeptides. | 2009-01-15 |
| 20090017499 | RANK LIGAND-BINDING POLYPEPTIDES - The present invention relates to a polypeptide having an amino acid sequence that differs from and is at least 70% identical to the amino acid sequence of hRANK, and which has a binding affinity to RANKL that is at least as high as the binding affinity of hRANK to RANKL, as determined by the functional competition assay described herein. | 2009-01-15 |
| 20090017500 | INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES - The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids. | 2009-01-15 |
| 20090017501 | INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES - The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids. | 2009-01-15 |
| 20090017502 | INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES - The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids. | 2009-01-15 |
| 20090017503 | Method and Apparatus for Saccharide Precipitation From Pretreated Lignocellulosic Materials - A method for separating saccharide components and lignin fractions from a concentrated acid treated lignocellulosic biomass is disclosed. The method involves precipitating the saccharide components by adding an organic solvent to the biomass slurry. The acid may then be recovered, for example, by filtration or by countercurrent washing and the organic solvent may be flashed and recycled. During acid recovery and organic recovery steps, two main lignocellulose components (hemicellulose and lignin) as well as minor components such as acetic acid are separated as well. The method decreases the amount of cellulase required for hydrolysis, increases hydrolysis rates, reduces formation of inhibitor molecules, increase sugar yields, produces high value by-products such as high quality lignin and hemicellulose, and decreases energy and equipment costs. | 2009-01-15 |
| 20090017504 | Method for preparing 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (ginsenoside M1) by using sanqi leaves and stems - The present invention provides a method for preparing 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (Ginsenoside M1) by using Sanqis leaves and stems. The method of the invention includes the steps of: (a) provides powder of Sanqi leaves and stems; (b) provides a fungus for fermenting the Sanqi leaves and stems, wherein the fermentation temperature is ranged from 20-50° C., the fermentation humidity is ranged from 70-100%, the pH value is ranged from 4.0-6.0, and the fermentation period is ranged from 5-15 days; (c) extracts and collects the fermentation products; and (d) isolates 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol from the fermentation products. | 2009-01-15 |
| 20090017505 | Process and device for mixing microdroplets - In a process for mixing microdroplets ( | 2009-01-15 |
| 20090017506 | CONTINUOUS FERMENTATION PROCESS TO PRODUCE BACTERIAL CELLULOSIC SHEETS - A process to obtain multiple bacterial cellulose sheets without the need to replace new fermentation medium in the tray is provided. The medium is prepared and medium components in water are dissolved. The medium is sterilized and heated to 115° C. for 20 minutes, cooled to 30° C., inoculated with a suspension of bacteriae, and distributed in the trays that are left to rest. The sheets are harvested and drained over the corresponding trays. Further steps include repetition of the fermentation in the trays left to rest and harvest of the sheets from the trays, draining them over the corresponding trays until the volume of medium in the tray is 15%-25% of the initial volume. Then, a new medium should be added. Fermentation and draining is repeated until the volume of medium in the tray is 15%-25% of the initial volume, when new medium is added and the cycle is re-started. | 2009-01-15 |
| 20090017507 | DRY GRANULATED PRODUCT CONTAINING L-LYSINE AS MAIN COMPONENT - Hydrochloric acid, sulfuric acid or an L-lysine solution having an equivalent ratio of anion/L-lysine higher than 0.95 is added to a raw material L-lysine solution having an equivalent ratio of anion/L-lysine lower than 0.68 to adjust the equivalent ratio of anion/L-lysine of the raw material solution to be in the range of 0.68 to 0.95, and the obtained L-lysine solution or a concentrate thereof is granulated and dried to obtain a dry granulated product having a high L-lysine content and showing low caking property and low hygroscopic property. | 2009-01-15 |
| 20090017508 | Streptomyces Avermitilis Gene Directing The Ratio of B2:B1 Avermectins - The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of | 2009-01-15 |
| 20090017509 | METHOD FOR THE PRODUCTION OF RAMIPRIL - An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method. | 2009-01-15 |
| 20090017510 | Enzymic method for the enantioselective reduction of keto compounds - The invention relates to an enzymatic method for the enantioselective reduction of organic keto compounds to the corresponding chiral hydroxy compounds, an alcohol dehydrogenase from | 2009-01-15 |
| 20090017511 | ALCOHOL PRODUCT PROCESSES - The present invention relates to processes for production of an alcohol product from granular starch comprising a pre-treatment at an elevated temperature below the initial gelatinization temperature of said granular starch followed by simultaneous saccharification and fermentation, and optionally recovery of ethanol. | 2009-01-15 |
| 20090017512 | APPARATUS AND METHODS FOR THE PRODUCTION OF ETHANOL, HYDROGEN AND ELECTRICITY - The compositions, methods and apparatus of the present invention allow the production of electricity, ethanol and hydrogen, and combinations thereof. In some embodiments, the invention provides a process for generating electricity or hydrogen comprising supplying a microbial catalyst and a fuel source to a microbial fuel cell or a bio-electrochemically assisted microbial reactor (BEAMR), respectively, under thermophilic conditions. In other embodiments, the invention provides a process of generating ethanol and electricity or ethanol and hydrogen comprising supplying a microbial catalyst and a fuel source to a fermentation vessel in operable relation with a microbial fuel cell or a BEAMR system, respectively, wherein the microbial catalyst has a cellulolytic activity, an ethanologenic activity, and an electricigenic activity. Other embodiments include compositions and apparati for practicing the invention. | 2009-01-15 |
| 20090017513 | PROCESS FOR PRODUCING HYDROCARBON MOLECULES FROM RENEWABLE BIOMASS - Provided is a process for producing hydrocarbon molecules from biomass utilizing microorganisms that are resistant to extreme heat and pressure, that comprise nucleic acid molecules encoding enzymes which degrade compounds selected from the group consisting of cellulose, lignin, xylan and hemicellulose, and which are capable of generating hydrocarbon molecules from the degraded cellulose, lignin, xylan and hemicellulose. | 2009-01-15 |
| 20090017514 | MEMBRANE SUPPORTED BIOREACTOR FOR CONVERSION OF SYNGAS COMPONENTS TO LIQUID PRODUCTS - Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO | 2009-01-15 |
| 20090017515 | Process for Microbial Production of a Valuable Compound - The present invention relates to a process for the production of a valuable compound by cultivation of a microorganism comprising cultivating the microorganism in a medium wherein all nutrients are provided in excess over the whole cultivation period and wherein a suitable amount of oxygen is fed to the culture to maintain the culture under conditions of oxygen limitation. | 2009-01-15 |
| 20090017516 | TARGET PHYSIOLOGICAL FUNCTION INACTIVATOR USING PHOTOSENSITIZER-LABELED FLUORESCENT PROTEIN - An object of the present invention is to provide a method of generating reactive oxygen species in a light irradiation-dependent manner, so as to inactivate any target physiological function. The present invention provides a target physiological function inactivator which consists of a photosensitizer-labeled fluorescent protein, wherein fluorescence resonance energy transfer (FRET) from the fluorescent protein to the photosensitizer occurs as a result of light irradiation, so that the photosensitizer can be excited to generate reactive oxygen species. | 2009-01-15 |
| 20090017517 | Preparation of Negative-Stranded RNA Viruses by Electroporation - The present invention encompasses methods of preparing non-segmented negative-stranded RNA viruses from cells utilizing electroporation. | 2009-01-15 |
| 20090017518 | Magnetic particles and fabrication method thereof - A magnetic particle and fabrication method thereof. The magnetic particle comprises a polymer core, a magnetic material layer covering the polymer core, and a silicon containing layer covering the magnetic material layer. In addition, the magnetic particle may further comprise a coupling agent on the silicon containing layer, and an active molecule connected to the coupling agent. The magnetic particles provide controllable size, uniform diameter distribution, high magnetization, improved storage stability, and modified surface for targeting biomolecules for biomaterial separation and environmental analysis. | 2009-01-15 |
| 20090017519 | Enzyme preparations for use as biocatalysts - The invention is directed to enzyme preparations which are obtainable by enzyme immobilizates which comprise enzymes or microorganisms containing enzymes immobilized on an inert carrier being provided with a silicone coating obtained by hydrosilylation, to a process for producing such enzyme preparations and to the use of enzyme preparations as an industrial biocatalyst. | 2009-01-15 |
| 20090017520 | Process and Materials for Production of Glucosamine - The present invention relates to a method and materials for producing glucosamine by fermentation of a genetically modified microorganism. Included in the present invention are genetically modified microorganisms useful in the present method for producing glucosamine, as well as recombinant nucleic acid molecules and the proteins produces by such recombinant nucleic acid molecules. | 2009-01-15 |
| 20090017521 | Chimaeric phages - The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provide chimaeric phages having a coat comprising a protein mixture. The protein mixture comprises a fusion protein having a proteinaceous molecule fused to a functional form of a phage coat protein and a mutant form of the phage coat protein, wherein the mutant form is impaired in binding to a host cell receptor. The invention further provides new phage collections, novel helper phages and methods and means for producing chimaeric phages, infectious phages and helper phages. | 2009-01-15 |
| 20090017522 | Polynucleotides Encoding Promyostatin Polypeptides - The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can specifically hybridize to such polynucleotides. The present invention also provides an isolated polynucleotide encoding a mature myostatin peptide. | 2009-01-15 |
| 20090017523 | Virus purification methods - Provided is a method for purifying a virus from a host cell, the method comprising: a) culturing host cells, b) infecting the host cells with a virus, c) treating the cell culture with nuclease, and d) lysing the host cells to provide a lysate comprising the virus. The virus may be recombinant adenovirus. Further provided are methods for purifying a recombinant virus expressing a heterologous protein capable of binding nucleic acid, comprising: a) culturing host cells, b) infecting the host cells with recombinant virus, c) lysing the host cells to provide a lysate comprising the recombinant virus, d) subjecting the recombinant virus to anion exchange chromatography and size exclusion chromatography, wherein the virus-containing mixture is buffer exchanged at least once with a solution comprising at least 2 M NaCl, or another salt providing an equivalent ionic strength. | 2009-01-15 |
| 20090017524 | PRODUCT FOR THE TREATMENT OF WASTEWATERS AND SEWAGE - Biodegradable support carrying a mixture of non-pathogenic bacteria that synergistically cooperate in decomposing the organic pollutants present in toilet wastewaters and in sewage collection and processing tanks. | 2009-01-15 |
| 20090017525 | S-TRIAZINE-HERBICIDE-DEGRADING BACTERIA, PRODUCT FOR THE BIOREMEDIATION AND METHOD OF BIOREMEDIATION - The present invention provides a bacterial strain which is able to degrade or mineralize s-triazine compounds, such as simazine, which corresponds to | 2009-01-15 |
| 20090017526 | METHOD OF USING ENDOPHYTIC FUNGI TO DECONTAMINATE AND DECOMPOSE HUMAN AND ANIMAL WASTES - A method of treating human and/or animal waste products comprising contacting the waste products with an effective amount of | 2009-01-15 |
| 20090017527 | ADVANCED GENETIC VACCINES - Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for inducing an enhanced immune response against a selected antigen. | 2009-01-15 |
| 20090017528 | Nucleic Acid Hybridization Device - The present invention relates to a hybridization device coupled by means of vibration to shorten the time needed for hybridization. This hybridization device of the present invention comprises an oscillation generating unit; a spacer attached to the top of the oscillation generating unit, which wraps around to form a tank, and the tank is loaded with a transmission solution; a loading plate having a loading face was paved with at least one nucleic acid probe, and the flip side of the loading face is a transmission face, which covers on top of the spacer to form a closed space, and is attached with the transmission solution. The vibration generated by the oscillation generating unit can be propagated to the loading plate through the transmission solution to promote the effective mixing of the nucleic acid to be analyzed and the probe, further to shorten the time needed for nucleic acid hybridization and to increase the detection sensitivity. | 2009-01-15 |
| 20090017529 | SCALABLE WALL BIOREACTOR FOR CULTURE OF PLANT AND ANIMAL TISSUES - A flexible wall bioreactor is described that uses a small droplet size mist unit, a lower rate ambient air flow rate, and a flexible wall culture chamber to provide an environment that allows for the growth of dense root matrix, shoot cultures, and 2 and 3 dimensional animal tissues. | 2009-01-15 |
| 20090017530 | Viral vectors whose replication and, optionally, passenger gene are controlled by a gene switch activated by heat in the presence or absence of a small-molecule regulator - The present invention relates to conditionally replicating viruses or pairs of viruses containing a gene switch that is activatable by transient heat or other proteotoxic stress in the presence or absence of a small molecule regulator. The gene switch controls the expression of a gene for a protein required for efficient viral replication and may also control the activity of a passenger gene. | 2009-01-15 |
| 20090017531 | METHOD FOR ISOLATING PLASMIDS FROM SUSPENDED BACTERIAL OR YEAST CELLS - A method for isolating plasmids from suspended bacterial or yeast cells using a filter matrix, at least one lysing substance being added to the suspension and predamaging or completely lysing the predominant portion of the suspended cells, at least one conformation-altering substance being added to the suspension to alter the conformation of the plasmids to be isolated so as to promote retention of the cell components in or at the filter matrix. The suspension is thereupon moved through the filter matrix and the cells if not yet lysed then being lysed to completion upon contact with the filter matrix and the released plasmids being retained in or at the filter matrix. | 2009-01-15 |
| 20090017532 | Vector - A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor. | 2009-01-15 |
| 20090017533 | OPTIMIZED MESSENGER RNA - The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common codons. | 2009-01-15 |
| 20090017534 | SLO2 AND SLO4, NOVEL POTASSIUM CHANNEL PROTEINS FROM HUMAN BRAIN - The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods of screening for potassium channel activators and inhibitors using biologically active Slo2 and Slo 4, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Slo2 and Slo 4. | 2009-01-15 |
| 20090017535 | MODIFIED GREEN FLUORESCENT PROTEINS AND METHODS FOR USING SAME - The present invention provides nucleic acid molecules encoding mutant fluorescent proteins as well as proteins encoded by these nucleic acids. In addition, host-cells, stable cell lines and transgenic organisms comprising the above-referenced nucleic acid molecules are provided. The subject protein and nucleic acid compositions find use in a variety of different applications and methods, particularly for labeling of biomolecules, cells, or cell organelles. | 2009-01-15 |
| 20090017536 | MODIFIED VACCINIA ANKARA VIRUS VARIANT AND CULTIVATION METHOD - The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a medicament or vaccine. A method is provided for inducing an immune response in individuals who may be immune-compromised, receiving antiviral therapy, or have a pre-existing immunity to the vaccine virus. In addition, a method is provided for the administration of a therapeutically effective amount of the virus, or its recombinants, in a vaccinia virus prime/vaccinia virus boost inoculation regimen. The present invention relates to a method of virus amplification in primary cells which are cultivated in a serum free medium. Viruses produced by this method are advantageously free of any infectious agents comprised in animal sera. | 2009-01-15 |
| 20090017537 | hT2R54 Receptor Polypeptides and Nucleic Acid Sequences - Functional assays that detect the effect of a particular compound or compounds on the activation of at least one human T2R polypeptide are provided. These assays include e.g., assays which detect the effect of said compound on intracellular calcium, second messengers such as cAMP, cGMP, current e.g., by use of voltage-clamp or patch-clamp, techniques, fluorescence polarization or FRET assays, and the like. These assays are useful in identifying compounds that putatively elicit or modulate (inhibit or enhance) bitter taste in human subjects, e.g. bitter taste blockers. The effect of identified compounds on taste may be further evaluated in human or animal taste tests. | 2009-01-15 |
| 20090017538 | Mammalian MDM2 Binding Proteins and Uses Thereof - Isolated nucleic acid sequences encoding mammalian binding protein and polypeptide sequences for the mammalian MDM2 binding protein are provided. Also provided are vectors containing these nucleic acid sequences, host cells which express these proteins and antibodies targeted to these proteins. In addition, methods and compositions for modulating the G | 2009-01-15 |
| 20090017539 | METHODS AND MEANS FOR STEM CELL PROLIFERATION AND SUBSEQUENT GENERATION AND EXPANSION OF PROGENITOR CELLS, AS WELL AS PRODUCTION OF EFFECTOR CELLS AS CLINICAL THERAPEUTICS - The invention provides means and methods for stem cell proliferation and subsequent generation and expansion of progenitor cells. The invention in particular provides media and other culture conditions for the same. The cells are preferably used as effector cells as clinical therapeutics. | 2009-01-15 |
| 20090017540 | METHOD OF CULTURING CELLS UNDER REGULATION IN THE EXTENSION DIRECTION - [Problems]Relating to a bioassay method with the use of cultured cells and cell culture for a therapeutic purpose in the case of determining the efficacy of a drug or the like or examining the toxicity thereof, it is intended to provide a method of culturing cells under regulation in the extension direction and a cell culture plate. | 2009-01-15 |
