02nd week of 2010 patent applcation highlights part 44 |
Patent application number | Title | Published |
20100009862 | BIOMOLECULE SENSOR, METHOD FOR MANUFACTURING THE SAME, BIOMOLECULE DETECTION METHOD, AND BIOMOLECULE DETECTION SYSTEM - The present invention aims to improve detecting accuracy and reproducibility of a biomolecule sensor. The biomolecule sensor of the present invention includes single probe molecules orderly aligned and fixed on grid points on the surface of a substrate. Accordingly, in the biomolecule sensor of the present invention: probe molecules for detecting a biomolecule are orderly aligned and separately fixed; blocking for preventing non-specific adsorption is applied to a region other than the region of the probe molecules for detecting a biomolecule; and fluorescence enhancement is achieved by metal microparticles. | 2010-01-14 |
20100009863 | METHOD FOR ENGINEERING T-CELL RECEPTORS - The present invention provides a method for engineering a T-cell receptor domain polypeptide comprising at least one modification in a structural loop region of said T-cell receptor domain polypeptide and determining the binding of said T-cell receptor domain polypeptide to an epitope of an antigen, wherein the unmodified T-cell receptor domain polypeptide does not significantly bind to said epitope, comprising the steps of providing a nucleic acid encoding a T-cell receptor domain polypeptide comprising at least one structural loop region, modifying at least one nucleotide residue of at least one of said structural loop regions, transferring said modified nucleic acid in an expression system, expressing said modified T-cell receptor domain polypeptide, contacting the expressed modified T-cell receptor domain polypeptide with said epitope and determining whether said modified T-cell receptor domain polypeptide binds to said epitope. The present invention also covers modified T cell receptor domain polypeptides obtained by said method and their use and libraries containing said modified T cell receptor domain polypeptides. | 2010-01-14 |
20100009864 | Method for analysing amplified nucleic acids - An example embodiment of the present invention discloses a method for analyzing nucleic acids in a microfluidic device. The method includes the following steps: a) nucleic acids are amplified in a first chamber in the microfluidic device; b) the amplified nucleic acids are brought into contact with an additive including: i) monovalent cations and ii) an Mg2+ ion-binding agent, the additive being provided in a second chamber in the microfluidic device; and c) the amplified nucleic acids are hybridized on at least one probe oligonucleotide. | 2010-01-14 |
20100009865 | OLIGONUCLEOTIDE ARRAYS - The present invention provides for oligonucleotide arrays wherein the oligonucleotides comprise six-membered sugar-ring nucleosides, especially tetrahydropyran nucleosides, more specifically altritol nucleosides. The present invention also provides for the use of said oligonucleotide arrays for detecting target molecules in samples (diagnostic or experimental use). The present invention also provides for a method of detecting target molecules in samples by using said oligonucleotide arrays comprising six-membered sugar-ring nucleosides. | 2010-01-14 |
20100009866 | Surface Display of Whole Antibodies in Eukaryotes - Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are useful for screening libraries of recombinant immunoglobulins in eukaryote host cells to identify immunoglobulins that are specific for an antigen of interest. | 2010-01-14 |
20100009867 | MULTI-MODAL ION EXCHANGE CHROMATOGRAPHY RESINS - The present invention relates to a method of preparing a library of resins which are useful in chromatography, which method comprises creating a diversity of multi-modal ion exchange resins; and providing the diversity in a parallel system in which each resin is presented separated from the other resin(s). | 2010-01-14 |
20100009868 | Self-Assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing - The present invention provides combinatorial encoding nucleic acid tiling arrays and methods for their use and synthesis. | 2010-01-14 |
20100009869 | ANTIBODY LIBRARIES - The present invention relates to the production of antibody libraries. In particular, the present invention relates to the use of integrating retroviral vectors to generate libraries comprising a plurality of combinations of antibody light chains and heavy chains. The present invention thus provides improved methods of generating and screening antibody libraries comprising large numbers of unique antibodies. | 2010-01-14 |
20100009870 | BIOMOLECULE-IMMOBILIZED PLATE AND METHOD FOR FABRICATING BIOMOLECULE-IMMOBILIZED PLATE - There is provided a biomolecule-immobilized plate having a flat part, at least a surface of the flat part comprising a polymer material, wherein the flat part has an arithmetic average roughness of 0.1 nm˜5 nm, and a portion of the flat part has functional groups. Further, the biomolecule-immobilized plate is fabricated by irradiating the flat part of the plate surface which comprises the polymer material, with an ultraviolet ray under ozone atmosphere to produce functional groups having bonding ability to the biomolecules on a portion of the flat part. Thereby, it is possible to provide a biomolecule-immobilized plate having a surface of a high degree of smoothness on which functional groups are produced, a biomolecule-immobilized plate on which biomolecules are immobilized via functional groups, and methods for fabricating these biomolecule-immobilized plates easily and inexpensively. | 2010-01-14 |
20100009871 | DEVICES AND SYSTEMS FOR CREATION OF DNA CLUSTER ARRAYS - The present invention comprises systems and devices for isothermal amplification of polynucleotide sequences to produce DNA cluster arrays. | 2010-01-14 |
20100009872 | Single molecule loading methods and compositions - Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided. | 2010-01-14 |
20100009873 | Thermally Stable Compositions and Use Thereof in Drilling Fluids - A composition is comprised of a mixture of the reaction product of an amine and a poly-functional isocyanate, and the reaction product of (i) a carboxylic acid with at least two carboxylic moieties; (ii) a polyamine having an amine functionality of two or more; and a chemical selected from the group consisting of (i) alkoxylated alkyl amines, (ii) fatty acid amides and (iii) mixtures thereof, and it is used as a drilling fluid additive. | 2010-01-14 |
20100009874 | PRECIPITATED WEIGHTING AGENTS FOR USE IN WELLBORE FLUIDS - A method of formulating a wellbore fluid that includes precipitating a weighting agent from a solution; and adding the precipitated weighting agent to a base fluid to form a wellbore fluid is disclosed. Fluids and methods of formulating wellbore fluids that contain dispersant coated precipitated weighting agents are also disclosed. | 2010-01-14 |
20100009875 | Liquid Additives for the Stabilization of Lubricant Compositions - A lubricating oil composition comprising: (A) a base stock; and (B) a liquid additive package. The liquid additive package comprises: (i) an alkylated diphenylamine; (ii) at least 5 weight % of a phenyl naphthylamine, based on the weight of the additive package; and (iii) a sulfur-containing phenol. | 2010-01-14 |
20100009876 | LUBRICATING OIL COMPOSITION - Provided is a lubricating oil composition comprising a base oil for a lubricating oil, (A) a fatty acid partial ester compound, 0.5 to 1.5% by mass of (B) (b1) an aliphatic amine compound and/or (b2) an acid amide compound, 0.01 to 0.1% by mass of (C) a specific benzotriazole derivative and a specific amount of (D) a specific succinimide compound. It is a lubricating oil composition of an environmental regulation compliant type which is used for internal combustion engines such as gasoline engines, diesel engines, engines using dimethyl ether for fuel, gas engines and the like, which does not contain Mo base friction reducing agents and is reduced in ash, phosphorus and sulfur and in which a friction reducing effect, an oxidation stability and a corrosion inhibiting effect are enhanced. | 2010-01-14 |
20100009877 | LUBRICANT COMPOSITIONS AND METHODS OF MAKING SAME - Compositions are described that include a) from 15 weight percent to 60 weight percent of one or more random alkylene oxide interpolymers, each having a weight average molecular weight ranging from 250 g/mol to 2000 g/mol and comprising from 30 weight percent to 60 weight percent of polymer units derived from ethylene oxide; and b) from 40 weight percent to 85 weight percent of one or more alkylene oxide block interpolymers, each having a weight average molecular weight ranging from 1500 g/mol to 4000 g/mol and comprising from 40 weight percent to 90 weight percent propylene oxide blocks. The compositions have a first viscosity in the absence of water and a second viscosity that is at least 60 percent of the first viscosity when at least 10 weight percent water is present. Methods of lubricating surfaces, particularly, marine bearing surfaces with such compositions, are also described. | 2010-01-14 |
20100009878 | LUBRICATING OIL COMPOSITION - The present invention aims to provide a lubricating oil composition capable of use in for example the bearings of a high-speed main shaft having ceramics ball antifrication bearings operating under severe conditions of high speed and high load. | 2010-01-14 |
20100009879 | METHOD OF LUBRICATING A CONVEYOR BELT - The present invention relates to a method of lubricating a conveyor belt, wherein a lubricant concentrate containing at least 0.1 wt-% of at least one free fatty acid and at least one corrosion inhibitor is employed as a dry lubricant in a dry lubrication process. | 2010-01-14 |
20100009880 | LUBRICATING OIL COMPOSITION - The lubricating oil composition contains a base oil; (A) an acidic alkyl phosphate ester having a C6 to C20 alkyl group; (B) a dialkylamine and/or a trialkylamine; and (C) (c-1) a sulfur compound in an amount of 0.2 to 0.6 mass % as reduced to S, the sulfur compound containing no poly-sulfur bond which is equal to or longer than —S—S—S— in a molecule thereof and having an S content of the molecule of 15 mass % or more and (c-2) an optional thiophosphoric acid trihydrocarbyl ester in an amount of 0.1 to 1.0 mass %, the ester being represented by formula (I): | 2010-01-14 |
20100009881 | THERMALLY STABLE ZINC-FREE ANTIWEAR AGENT - There is disclosed a lubricant additive composition comprising a thermally stable, zinc-free, phosphorous-containing antiwear agent. Moreover, a lubricant composition comprising the disclosed additive composition is also disclosed. Methods for making and using the disclosed compositions are disclosed. | 2010-01-14 |
20100009882 | LUBRICATING OIL COMPOSITION FOR INTERNAL COMBUSTION ENGINE - A lubricating oil composition for an internal combustion engine, which includes a base oil, (A) at least one member selected from the group consisting of disulfide compounds represented by the general formula (I): | 2010-01-14 |
20100009883 | METHOD OF CLEANING A QUARTZ PART - A cleaning solution for a quartz part and a method for cleaning the quartz part are provided. The cleaning solution includes from about 5 to about 35 wt % of an ammonium compound, from about 7 to about 55 wt % of an acidic oxidizing agent, from about 5 to about 30 wt % of a fluorine compound and a remaining amount of water. Residual thin films and impurities on the surface of the quartz part may be removed while reducing the damage onto the quartz part. | 2010-01-14 |
20100009884 | Low Foaming Cleaner - Liquid compositions for cleaning, in particular medical instruments and air conditioning surfaces, said composition excluding surfactants and comprising one or more enzymes including a protease and optionally a hydrolase, a solvent system including a water soluble glycol ether solvent, at least one anionic hydrotrope, and wherein the molar ratio of said at least one hydrotrope to said glycol ether in the composition is selected to preserve the activity of said one or more enzymes. The hydrotrope is advantageously an anionic hydrotrope selected from the group consisting of water soluble anionic hydrotropes of the formula (I) and having no alkyl side chain greater than six carbons in length, for example a xylene sulfonate or cumene sulfonate salt. | 2010-01-14 |
20100009885 | COMPOSITION FOR REMOVING A PHOTORESIST, METHOD OF PREPARING THE COMPOSITION, METHOD OF REMOVING A PHOTORESIST AND METHOD OF MANUFACTURING A SEMICONDUCTOR DEVICE USING THE COMPOSITION - A composition for removing a photoresist includes about 5 to about 20 percent by weight of an alcoholamide compound, about 15 to about 60 percent by weight of a polar aprotic solvent, about 0.1 to about 6 percent by weight of an additive, and pure water. The alcoholamide compound is chemically structured as follows: | 2010-01-14 |
20100009886 | METHODS FOR MANUFACTURING AND USING A CLEANING COMPOSITION FOR HANDLING WATER HARDNESS - A method for providing a ready to use cleaning composition is provided. The method includes diluting a concentrate with water of dilution. The concentrate includes an anionic surfactant, an alkanolamine and a water hardness anti-precipitant mixture. The water hardness anti-precipitant mixture includes a maleic anhydride/olefin co-polymer and an EO-PO co-polymer. The EO-PO co-polymer having the formula: | 2010-01-14 |
20100009887 | Particle for Imparting a Fabric-Softening Benefit to Fabrics Treated Therewith and that Provides a Desirable Suds Suppression - The present invention relates to a particle comprising: (a) solid film-forming polymeric material; (b) liquid fabric-softening component; and (c) cationically charged polymeric material. | 2010-01-14 |
20100009888 | MICROEMULSION OR PROTOMICROEMULSION CLEANING COMPOSITION WITH DISRUPTING SURFACTANTS - A microemulsion or protomicroemulsion composition containing a disrupting surfactant for improved performance. | 2010-01-14 |
20100009889 | Dry Delivery Hypochlorite - This invention relates to dry powder forms of hypohalite, especially a dry powdered form of dilute or concentrated hypochlorite and hypochlorous acid compositions. The invention also relates to uses for these dry powders, such as for treating hard and soft inanimate surfaces, animate surfaces, air, and for deactivating allergens. | 2010-01-14 |
20100009890 | SOLVENT SYSTEM FOR MICROEMULSION OR PROTOMICROEMULSION AND COMPOSITIONS USING THE SOLVENT SYSTEM - A solvent system for use in a microemulsion or protomicroemulsion where the solvents are selected to have a Hansen parameter of δd to be from 15 to about 18; of δp to be from 0 to about 8 and of δH to be from 0 to about 12; such that the resulting Hansen parameter of the solvents comprises has a δd of from 15 to about 18; a δp from about 2 to about 8 and a δH of from about 5 to about 12. | 2010-01-14 |
20100009891 | Liquid cleansing compositions comprising microfibrous cellulose suspending polymers - The present invention relates to personal care liquid cleansing compositions comprising bacterially produced microfibrous cellulose (MFC) suspending polymers which have not previously been used in personal care compositions. | 2010-01-14 |
20100009892 | Multi-function surfactant composition - A surfactant concentrate is provided an admixture of a phosphonated amphoteric surfactant and a fluorosurfactant. The phosphonated surfactant may be used alone or in admixture with a second phosphonated surfactant, an additional amphoteric surfactant or a Zwitterionic surfactant. The fluorosurfactant may be either anionic, nonionic, or mixtures thereof. The surfactant composition may be used to formulate either a highly caustic detergent concentrate or an acid cleaner. The surfactant concentrate and cleaner made therefrom have a variety of uses. A highly caustic cleaner prepared from a surfactant concentrate is particularly usable in the brewing industry. | 2010-01-14 |
20100009893 | Microcapsules - Microcapsules comprising a core of fragrance and a shell of aminoplast polymer, the composition of the shell being from 75-100% of a thermoset resin comprising 50-90%, preferably from 60-85%, of a terpolymer and from 10-50%, preferably from 10-25%, of a polymeric stabilizer; the terpolymer comprising: (a) from 20-60%, preferably 30-50% of moieties derived from at least one polyamine, (b) from 3-50%, preferably 5-25% of moieties derived from at least one aromatic polyol; and (c) from 20-70%, preferably 40-60% of alkylene or alkylenoxy moieties having 1 to 6 methylene units, preferably 1 to 4 methylene units and most preferably 1 methylene unit; the microcapsules additionally optionally comprising up to 25%, preferably up to 10% of a cationic polymer. The microcapsules are useful for the storage and dissemination of fragrance in various products, such as laundry products and fabric care products. | 2010-01-14 |
20100009894 | Extended Delivery of Ingredients from a Fabric Softener Composition - A controlled delivery system for active ingredients, like a fragrance, for use in fabric softener products, such as tumble dryer sheets, rinse added liquids, and similar products, is disclosed. The delivery system enhances performance of an active ingredient, such as a fragrance. The controlled delivery system contains polymeric micro-particles highly loaded with the active ingredient. Other active ingredients that can be incorporated into a fabric softener composition using the delivery system include ironing aides, silicone fluids, antiwrinkle agents, antistatic agents, optical brighteners, fabric crisping agents, bleaching agents, germicides, fungicides, flow agents, and surfactants. | 2010-01-14 |
20100009895 | METHOD FOR SELECTIVE LOCALIZATION OF ACTIVE AGENTS AT AND IN MITOCHONDRIA AND CORRESPONDING ACTIVE AGENTS - The present invention relates to novel methods for selective localization of active agents both at and in mitochondria within living cells, as well as corresponding active agents that penetrate through the cell membrane into the cells without further adjuvants and there can be localized both at and in mitochondria. These active agents are substituted with at least one monohydroxy mononitrophenyl rest or monohydroxy dinitrophenyl rest. | 2010-01-14 |
20100009896 | CAPTURE AGENTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS - Multi-ligand capture agents comprising two or more ligands are described, and related compositions, methods and systems. | 2010-01-14 |
20100009897 | POLYPEPTIDE HAVING LARVAE GROWTH INHIBITING OR INSECTICIDAL EFFECT ON SCARABAEIDAE INSECTS AND POLYNUCLEOTIDE ENCODING THE SAME - Through screening using an antibody to a polypeptide that constitutes a parasporal body in sporangia of | 2010-01-14 |
20100009898 | PROTEASE RESISTANT INSULIN ANALOGUES - The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided. | 2010-01-14 |
20100009899 | Novel Insulin Derivatives - The present invention relates to insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the α-amino group of the N-terminal amino acid residue of the B chain or to the ε-amino group of a Lys residue present in the B chain of the parent insulin, the side chain being of the general formula: | 2010-01-14 |
20100009900 | SUBSTITUTED INDOLE-O-GLUCOSIDES - Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed. | 2010-01-14 |
20100009901 | Mineral Amino Acid Polysaccharide Complex - This document provides complexes comprising a mineral-amino acid compound and a polysaccharide. For example, the document provides compositions containing such complexes and methods of making and using such complexes. | 2010-01-14 |
20100009902 | Glycoconjugation Using Saccharyl Fragments - The present invention provides conjugates between a substrate, e.g., peptide, glycopeptide, lipid, etc., and a modified saccharyl fragment bearing a modifying group such as a water-soluble polymer, therapeutic moiety or a biomolecule. The conjugates are linked via the enzymatic conversion of the activated modified saccharyl fragment into a glycosyl linking group that is interposed between and covalently attached to the substrate and the modifying group. The conjugates are formed from substrates by the action of a sugar transferring enzyme, e.g., a glycosyltransferase. For example, when the substrate is a peptide, the enzyme conjugates a modified saccharyl fragment moiety onto either an amino acid or glycosyl residue of the peptide. Also provided are pharmaceutical formulations that include the conjugates. Methods for preparing the conjugates are also within the scope of the invention. | 2010-01-14 |
20100009903 | Methods for Promoting Wound Healing and/or Reducing Scar Formation - The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein. | 2010-01-14 |
20100009904 | Modified Exedins and Uses Thereof - Novel exendins with modifications at one or more of following positions: 2, 14, 27 or 28 and polyethylene glycol derivatives thereof are provided. These compounds are useful in treating type 2 diabetes as GLP-1 receptor agonists. | 2010-01-14 |
20100009905 | Compositions and Methods for Detection, Prognosis and Treatment of Colon Cancer - The present invention relates to methods of detection, prognosis and treatment of colon cancer using a plurality genes or gene products present in normal and neoplastic cells, tissues and bodily fluids. Additional uses include identifying, monitoring, staging, imaging and treating colon cancer and non-cancerous diseases of the colon as well as determining the effectiveness of therapies alone or in combination for an individual. | 2010-01-14 |
20100009906 | Anticancer Treatments - A method of treating the human body for cancer comprises administering an effective therapeutic amount of docetaxel in combination with an effective therapeutic amount of ET-743. | 2010-01-14 |
20100009907 | Glucagon-Like Peptides and Uses Thereof - The present invention relates to non-mammalian Glucagon-like peptides (nmGLP-1), analogs thereof, related nucleic acids, and processes production of such peptides. The nmGLP-1 peptides and analogs thereof of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent obesity, reducing body weight, controlling glycemia, controlling or reducing appetite, and reducing food intake. | 2010-01-14 |
20100009908 | Galectin 9-Polymer Conjugates - Galectin 9, which is an immune function-controlling factor belonging to a new class that is different from known cytokines and is expected to be used as a therapeutic drug for various immune-related diseases such as an autoimmune disease, has disadvantages (such as high sensitivity to protease and poor solubility) to be solved in developing therapeutic drugs. Therefore, there is a need to overcome these disadvantages. Chemically modified galectin 9, prepared by conjugating a polymer (for example, poly(ethylene glycol: PEG) to galectin 9, in particular, stabilized galectin 9, is verified to exert higher solubility with improvements in pharmacodynamics and pharmacokinetics (for example, prolongation of action potential duration, such as prolongation of blood half-life and others) and in suppression of hemagglutination and thus has excellent characteristics as a drug. | 2010-01-14 |
20100009909 | PEPTIDES BINDING THE PHOSPHATASE 2A PROTEIN - The invention relates to novel synthetic or natural E4orf4 or Bcl-2 peptides particularly useful in antitumoral, antiviral and antiparasitic treatments, said peptides being less than 30 amino acids long and binding in vitro to a phosphatase 2A protein holoenzyme or one of its subunits. The invention also relates to polynucleotides encoding the novel peptides, vectors expressing same, as well as antibodies identifying same and probes identifying transcripts thereof. | 2010-01-14 |
20100009910 | METHODS FOR ADMINISTERING LONG-LASTING HYPOGLYCEMIC AGENTS - The present invention relates to methods and pharmaceutical compositions relating to administering hypoglycemic agents and/or GLP-1 agonists wherein the mean maximum plasma concentration (Cmax) and/or Area Under the Curve (AUC) values of the hypoglycemic agent are increased and/or sustained. | 2010-01-14 |
20100009911 | Osteogenic synergic composition - The invention relates to an osteogenic synergic composition comprising at least one osteogenic growth factor, and at least one growth factor having a chemoattractant and angiogenic capacity. It also relates to the method for the preparation thereof and to the use thereof for the preparation and production of pharmaceutical products for use in bone reconstruction and regeneration, in the form of topical compositions, for example implants, pastes or gels. | 2010-01-14 |
20100009912 | INSECTICIDAL EXTRACT FROM LEGUME PLANTS AND METHOD OF PREPARING THE SAME - The invention may be summarized as follows. The present invention provides insecticides comprised of naturally-occurring compounds, such as, for example, PA1b-related peptides and terpenoid saponins. The present invention also provides for identification and characterization of a synergistic insecticidal effect between peptides and saponins extracted from plants. Furthermore, simplified extraction procedures are provided that avoid the use of a chloroform defatting step or a column chromatography step. | 2010-01-14 |
20100009913 | Uses for Yerba Santa - Methods of in vitro propagation of plants of the genus | 2010-01-14 |
20100009914 | METHOD OF PROTECTING SENSITIVE MOLECULES FROM A PHOTO-POLYMERIZING ENVIRONMENT - In one embodiment, the present invention is a substrate system of photo-polymerizable monomers and bioactive molecules admixed with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature. Upon polymerization, the monomers produce a cross-linked structure and the shielded bioactive molecules are protected from attack in the polymerized environment. In different aspects, the substrate system is used for drug delivery and tissue engineering and protection of enzymes, proteins and growth factors. In another embodiment, the present invention is a drug delivery system of photo-polymerizable monomers, drug molecules associated with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature, and a photopolymerizing means for polymerizing the monomers to produce a cross-linked structure including the drug molecules. | 2010-01-14 |
20100009915 | COMPOSITIONS COMPRISING FUNGAL IMMUNOMODULATORY PROTEIN AND USE THEREOF - This invention relates to a method for stimulation or an activation of immunological function directed to activate natural killer cells and macrophages or increase production of serum antibody in a patient in need of such stimulation or activation, comprising administering an isolated and/or purified polypeptide of a fungal immunomodulatory protein. This invention also relates to a method for suppressing proliferation of a cancer cell and a method for suppressing a tumor cell mobility, comprising providing to the tumor cell a purified polypeptide of a fungal immunomodulatory protein. | 2010-01-14 |
20100009916 | SELECTIVE VPAC2 RECEPTOR PEPTIDE AGONISTS - The present invention encompasses peptides that selectively activate the VPAC2 receptor and are useful in the treatment of diabetes. | 2010-01-14 |
20100009917 | Modulating Enzymatic Processes by Addition of Diolcontaining Substances - The present invention relates to a method for increasing the selectivity of an enzyme, which method comprises performing the reaction in the presence of an enhancing compound selected from one of ethylene glycol, propylene glycol or glycerol. | 2010-01-14 |
20100009918 | METHOD FOR THE ADMINISTRATION OF LIGANDS, AGONISTS OF LIGANDS OF THE TNF FAMILY WITH REDUCED TOXICITY - The present invention concerns the use of a multimerized form of ligands of the TNF family for the preparation of a medicament for injection into an appropriate cavity of the body, for the treatment of diseases wherein cell proliferation has to be controlled wherein the ligand of the TNF family is selected among Fas ligand, CD40L, TRAIL and APRIL. | 2010-01-14 |
20100009919 | Apolipoprotein A1 Mimetics and Uses Thereof - The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also provides pharmaceutical compositions and methods of treatment for elevated levels of plasma cholesterol. | 2010-01-14 |
20100009920 | TTK AS TUMOR MARKER AND THERAPEUTIC TARGET FOR LUNG CANCER - Disclosed herein is a method for determining kinase activity of TTK for EGFR and methods of screening for modulators of this kinase activity. Also disclosed are methods and pharmaceutical compositions for preventing and/or treating lung cancer that use or include such modulators. Methods for diagnosing lung cancer using the kinase activity of TTK for EGFR protein as an index as well as methods for assessing and prognosing lung cancer are also provided. | 2010-01-14 |
20100009921 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR PEPTIDE TREATMENT - Disclosed are compositions and methods for treating a patient with a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins, wherein the pharmaceutical composition is in the form of an emulsified nasal spray comprising: a macrocyclic permeation enhancer, a liquid carrier comprising water, and a therapeutically effective amount of a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins; wherein the macrocyclic permeation enhancer is a Hsieh enhancer emulsified in the liquid carrier; and wherein the Hsieh enhancer has the following structure: | 2010-01-14 |
20100009922 | HYPOTENSIVE PEPTIDES FROM SOY PROTEINS AND METHOD OF PREPARATION - A method for preparing an anti-hypertension peptide composition, using a microbe which is intrinsic to common soybean food and capable of producing protease. The composition mainly contain peptides with a molecular weight of less than 10 kD which are produced by decomposition of soy proteins by the microbe in a fermentation process. The composition is shown to have an ACE inhibitory activity and an effect of lowering blood pressure when administered to a mammalian subject. | 2010-01-14 |
20100009923 | Antigens Targeted by Pathogenic Al4 T Cells in Type 1 Diabetes and Uses Thereof - Provided are oligopeptide antigens to A14-like T cells, and mouse proteins comprising those antigens. The oligopeptide antigens comprise the amino acid sequence XX(I/D/F/L)ENY(I/L)(E/W/Y)(L/M) or VMLENYTHL. Additionally provided are methods for treating a mammal having or at risk for type 1 diabetes using these antigens, or compounds which reduce or eliminate expression of these antigens. Kits comprising these antigens, and methods for determining whether a mammal is at risk for or has type 1 diabetes are also provided. | 2010-01-14 |
20100009924 | Compositions and methods for improving cardiovascular function - The present invention relates to methods for supplementing the diet of subjects suffering from cardiovascular disease. D-Ribose is given long term alone or in combination with vasodilators in order to improve or maintain the diastolic or systolic function of the subjects. | 2010-01-14 |
20100009925 | 18-MEMBERED MACROCYCLES AND ANALOGS THEREOF - The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically | 2010-01-14 |
20100009926 | PH-SENSITIVE POLYMERIC MICELLES FOR DRUG DELIVERY - Mixed micelles containing poly(L-histidine-co-phenylalanine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed. | 2010-01-14 |
20100009927 | Anti-Inflammatory and Anti-Allergy Extracts from Nettle - The present invention relates in part to nettle extracts that are useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions. | 2010-01-14 |
20100009928 | COMPOSITIONS INCLUDING TRICIRIBINE AND TAXANES AND METHODS OF USE THEREOF - This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation. | 2010-01-14 |
20100009929 | COMPOSITIONS INCLUDING TRICIRIBINE AND BORTEZOMIB AND DERIVATIVES THEREOF AND METHODS OF USE THEREOF - This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation. | 2010-01-14 |
20100009930 | TREATMENT OF UTERINE CANCER AND OVARIAN CANCER WITH A PARP INHIBITOR ALONE OR IN CONBINATION WITH ANTI-TUMOR AGENTS - In one aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent. | 2010-01-14 |
20100009931 | ASSOCIATION OF A TENSOR AGENT OR DEVICE AND A SACCHARIDE COMPOUND - The invention concerns a composition for topical application on the skin comprising, in a physiological acceptable medium, at least one saccharide compound which augments the expression of mechanoreceptors in skin cells and at least one tensor agent. The invention also concerns a skin care health kit comprising (a) a composition comprising at least one tensor agent and (b) a composition comprising at least one saccharide compound which increases the expression of mechanoreceptors in skin cells. The invention also concerns a kit comprising (a) a composition comprising at least one saccharide compound which augments the expression of mechanoreceptors in skin cells and (b) a tensor device designed to apply and/or maintain in a controlled manner mechanical constraints on the skin. The invention also concerns a process for cosmetic treatment of the skin comprising the simultaneous or sequential application of said compositions and/or tensor devices. | 2010-01-14 |
20100009932 | Liquid Satiety Enhancing Composition - The present invention relates to shelf-stable satiety enhancing and/or satiating liquid compositions that can be used as satiety enhancing and/or satiating composition in a method of treating or preventing any of a variety of diseases and/or disorders associated with overeating and/or excessive caloric intake of a subject. It was found that liquid compositions comprising specific combinations of pectins and alginates, can be used to reduce the tendency of a subject to overeat and/or to reduce caloric intake of a subject. These compositions have acceptable taste and texture characteristics, are convenient and/or economical to manufacture and, in particular, are stable during manufacture and storage, and, upon ingestion, gelate in the strongly acidic environment that prevails in the stomach. | 2010-01-14 |
20100009933 | HYDROXYLATED AMIDE SKIN MOISTURIZER - The invention relates to the cosmetic use, as a skin moisturizer, of a compound of formula (I): with (i) R | 2010-01-14 |
20100009934 | BETA ADRENERGIC RECEPTOR AGONISTS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS - The invention features a method of treating a B-cell proliferative disorder by administering to a patient a BAR agonist, e.g., formulated for administration by a route other than inhalation (such as for oral or intravenous administration), in an amount effective to treat the B-cell proliferative disorder. The BAR agonist may be administered as a monotherapy or in combination with one or more other agents, e.g., a PDE inhibitor, an A2A receptor agonist, or an antiproliferative compound, in amounts that together are effective to treat the B-cell proliferative disorder. The invention further features pharmaceutical compositions and kits including a BAR agonist, alone or in combination with additional agents, for the treatment of a B-cell proliferative disorder. | 2010-01-14 |
20100009935 | RESISTANCE-REPELLENT RETROVIRAL PROTEASE INHIBITORS - Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided. | 2010-01-14 |
20100009936 | CHEMICAL COMPOUNDS - The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immuno-suppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SIP receptors. | 2010-01-14 |
20100009937 | PESTICIDE FORMULATION WITH STREAMING BIREFRINGENCE - A pesticide composition exhibiting streaming birefringence and methods for making the pesticide composition are disclosed. In one embodiment, the pesticide composition comprises an active ingredient and a surfactant adjuvant. | 2010-01-14 |
20100009938 | METHOD TO IDENTIFY AND TREAT SUBJECTS RESISTANT TO ACETYL SALICYLIC ACID - The invention relates to the use of acetyl salicylic acid (ASA) in combination with MRP4 channel inhibitors for the treatment of all diseases related to so-called ASA resistance. Particularly preferred among the MRP4 channel inhibitors is dipyridamole. The invention also relates to an in-vitro diagnostic method for identifying ASA-resistant patients and to the associated kit for implementing the diagnostic method. | 2010-01-14 |
20100009939 | CONCURRENT DRUGS - The present invention provides a combination drug which is useful for the prevention or treatment of thromboembolism. A pharmaceutical agent comprising an antiplatelet agent in combination with a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: | 2010-01-14 |
20100009940 | 2-Methylene-(20E)-20(22)-Dehydro-19-Nor-Vitamin D Analogs - This invention discloses 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-(20E)-20(22)-dehydro-19-nor-1α,25-dihydroxyvitamin D | 2010-01-14 |
20100009941 | 2-Methylene-20(21)-Dehydro-19-Nor-Vitamin D Analogs - This invention discloses 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-20(21)-dehydro-19-nor-1α,25-dihydroxyvitamin D | 2010-01-14 |
20100009942 | 2-Methylene-(17Z)-17(20)-Dehydro-19,21-Dinor-Vitamin D Analogs - This invention discloses 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs, and specifically 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-1α, 25-dihydroxyvitamin D | 2010-01-14 |
20100009943 | 2-Methylene-(22E)-25-(1-Methylene-Hexyl)-26,27-Cyclo-22-Dehydro-19-Nor-Vit- amin D Analogs - This invention discloses 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-1α,24(R)-dihydroxyvitamin D | 2010-01-14 |
20100009944 | 19-Nor-Vitamin D Analogs with 1,2-Dihydrofuran Ring - 19-nor-vitamin D analogs having an additional dihydrofuran ring connecting the 1α-oxygen and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds exhibit selective in vitro and in vivo activities, making them therapeutic agents for the treatment or prophylaxis of autoimmune diseases, some types of cancers, secondary hyperparathyroidism, psoriasis, or other skin diseases. | 2010-01-14 |
20100009945 | 19-NOR-VITAMIN D ANALOGS WITH 3,2-DIHYDROFURAN RING - 19-nor-vitamin D analogs having an additional dihydrofuran ring connecting the 3β-oxygen and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds exhibit selective in vitro and in vivo activities, making them therapeutic agents for the treatment or prophylaxis of autoimmune diseases, some types of cancers, metabolic bone diseases, osteomalacia, osteopenia, secondary hyperparathyroidism, psoriasis, or other skin diseases. | 2010-01-14 |
20100009946 | 2-Methylene-19,26-Dinor-(20R,22E,25R)-Vitamin D Analogs - This invention discloses 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20R,22E,25R)-1α,25-dihydroxyvitamin D | 2010-01-14 |
20100009947 | 2-Methylene-19,26-Dinor-(20S,22E,25R)-Vitamin D Analogs - This invention discloses 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20S,22E,25R)-1α,25-dihydroxyvitamin D | 2010-01-14 |
20100009948 | Combined calcium, magnesium and vitamin D supplements - The present invention relates to oral nutritional and therapeutic products which are useful for providing vitamins and minerals required for bone health. The present invention is an oral nutritional and therapeutic composition of calcium succinate, magnesium R-(+)-alpha-lipoate, and Vitamin D for use in the maintenance of bone health, the optimization of bone growth, reducing the risk of bone fracture, and the prevention and treatment of osteoporosis. The pharmaceutical products and methods of the present invention are particularly useful in building bone mass, quality, and density during growth, maintaining bone mass, quality, and density over time, reducing bone fracture risk, and treating osteoporosis in men and women. | 2010-01-14 |
20100009949 | NOVEL METHOD - The invention provides for the use of Vitamin D compounds such as 1-alpha-fluoro-25-hydroxy-16,23E-diene-26,27-bishomo-20-epi-chole-calciferol, in the prevention or treatment of prostate cancer. | 2010-01-14 |
20100009950 | SUBSTITUTED ETHANOLAMINES - The present invention relates to new substituted ethanolamine adrenergic receptor modulators, pharmaceutical compositions thereof, and methods of use thereof. | 2010-01-14 |
20100009951 | Ciclesonide containing sterile aqueous suspension - The present invention relates to a sterile aqueous suspension containing ciclesonide, a microgel and a water soluble ionic polymer. The present invention provides a sterile aqueous suspension in which ciclesonide is dispersed homogeneously over a long period of time. | 2010-01-14 |
20100009952 | CONTROLLED RELEASE CORTICOSTEROID COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS - Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s). | 2010-01-14 |
20100009953 | CYCLOSPORIN DERIVATIVES FOR TREATING OCULAR AND DERMAL DISEASES AND CONDITIONS - The present invention provides a method for the treatment of ocular or dermal diseases and/or conditions, e.g. an aqueous deficient dry eye state, uveitis or phacoanaphylactic endophthalmitis in an eye, or balanitis, psoriasis, or atopic dermatitis of the skin, said method comprising administering, topically to the eye or the skin, a therapeutically effective amount of a novel cyclosporin A derivative selected from the group consisting of compounds represented by the formula: | 2010-01-14 |
20100009954 | BETA-LACTAMASE INHIBITORY COMPOUNDS - Inhibitors of the enzyme beta-lactamase are provided. The compounds are adapted to inhibit beta-lactamase as produced by beta-lactam resistant bacterial strains. Methods of treatment of beta-lactam resistant bacterial infections in patients are provided. | 2010-01-14 |
20100009955 | PHARMACEUTICAL COMPOSITIONS OF CEFIXIME - A pharmaceutical suspension formulation comprising a dose greater than 100 mg/5 ml Cefixime and pharmaceutically acceptable excipients. | 2010-01-14 |
20100009956 | NOVEL SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS - Substituted heteroaryl nitrile salts of Formula I, | 2010-01-14 |
20100009957 | NOVEL INHIBITORS OF BETA-LACTAMASE - A class of 7-oxo-2,6-diazabicyclo-[3.2.0]-heptane-6-sulfonic acid compounds substituted at the two position of the bicyclic ring with a heterocyclylaminocarbonyl group or a carbocyclylaminocarbonyl group are β-lactamase inhibitors. The compounds and their prodrugs and pharmaceutically acceptable salts are useful in the treatment of bacterial infections in combination with β-lactam antibiotics. In particular, the compounds are suitable for use with β-lactam antibiotics (e.g., imipenem and ceftazidime) against micro-organisms resistant to β-lactam antibiotics due to the presence of the β-lactamases. | 2010-01-14 |
20100009958 | QUINAZOLINE DERIVATIVES - Quinazoline derivatives of the following formula: | 2010-01-14 |
20100009959 | Pentacyclic Indole Derivatives as Antiviral Agents - The present invention relates to pentacyclic indole derivatives of formula (I): wherein A, Ar, R | 2010-01-14 |
20100009960 | PYRIDONE/HYDROXYPYRIDINE 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS - Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure formula (I) enantiomers, diastereomers, solvates, salts, tautomers or prodrugs thereof wherein, A, W, X, Y and R | 2010-01-14 |
20100009961 | DIPEPTIDYL PEPTIDASE-IV INHIBITORS - The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes. | 2010-01-14 |