Class / Patent application number | Description | Number of patent applications / Date published |
623150110 | Hair or skin | 40 |
20090198336 | CELL CO-CULTURE FOR HAIR FOLLICLE PRODUCTION - This invention relates to methods of producing hair folliclesin vitro, compositions for producing hair follicles in vitro, in vitro produced hair follicles, methods of providing an in vitro produced hair shaft at an interfollicular or intrafollicular site, methods of treating hair loss by providing an in vitro produced hair shaft at an interfollicular or intrafollicular site and assays for studying the effect of test agents on hair biology. The invention also provides the similar methods and products which are, or use, immature follicles (“defined herein as proto-hairs”). The invention provides a method for in vitro production of a hair follicle or a proto-hair comprising co-culturing dermal papilla cells with keratinocytes, and optionally with melanocytes. | 08-06-2009 |
20100305699 | STRUCTURE OF NATURAL OR ARTIFICIAL HAIR FOR TRANSPLANTATION AND HAIR TRANSPLANTATION METHOD USING THE SAME - The present invention relates to a structure of a natural or artificial hair for a hair transplant and, more particularly, to a processed structure of a natural or artificial hair for transplantation, comprising: a number of fixing cut parts formed lengthwise on the outer circumferential surface line of a lower end part of a natural or artificial hair to be transplanted to a scalp of a person, that is, on the outer circumferential surface line of an insertion part to be inserted inside the scalp, the fixing cut part cut perpendicular to the outer circumferential surface line of the insertion part and formed along the outer circumference surface of the insertion part while having a predetermined angle toward the center of the hair. | 12-02-2010 |
20110202134 | Coated Substrate With Properties of Keratinous Tissue - Article of manufacture comprising a substrate and a coating layer. The coating layer comprises at least one coating material, and is stably affixed to the substrate to form a stable, coated surface. The coated surface has a texture that mimics the topography of mammalian keratinous tissue and demonstrates at least one physical property representative of mammalian keratinous tissue, selected from the group consisting of a total surface energy of from about 15 mJ/m | 08-18-2011 |
20120158138 | Adjustable Hair Transplantation Chair - A convertible chair, for example, a hair transplantation chair that permits movement of the patient during a procedure while the patient's head remains substantially stationary. The chair may include a head support and a plurality of body supports that may be mounted on a base, or on a cradle movably attached to the base. The chair can be configured for a follicular unit harvesting procedure and it could be also converted into a hair implantation configuration for hair implantation procedure. The patient remains in the chair during the procedure with his head substantially stationary, while various parts of his body may be repositioned, for example, by rotation of the cradle. The chair may be automated, or assisted with pneumatics, motors, foot pumps and the like. The chair is particularly useful for assisting robotic hair transplantation procedures. | 06-21-2012 |
20140088706 | HAIR TRANSPLANT MATERIAL - A hair transplantation material prepared by a process comprising: refrigerating a hair portion comprising a hair shaft, a hair root, and a cell-collagen layer; and sterilizing the refrigerated hair. | 03-27-2014 |
20140277453 | CILIARY IMPLANT, CILIARY AUGMENTATION - A prosthesis for eyelash replacement, restoration, or augmentation includes an implantable base serving a substrate at a ciliary implant site in proximity to a native eyelash line, and a plurality of artificial eyelash hairs secured to the implantable base at intervals along and extending from the implantable base to mimic the look of real human eyelashes. The implantable base may be composed of an absorbable material or a non-reactive, non-absorbable substance and may be curvilinear, rectangular, or round with an annular cross-section in shape. The plurality of artificial eyelash hairs are of a flexible material, preferably composed of a keratin-base or inert fiber, secured, knotted, permanently fixed to the implantable base to mimic native eyelash. A method of eyelash replacement, restoration, or augmentation comprises selecting a ciliary implant site in proximity to a native eyelash line, making an incision corresponding to the ciliary implant site deepened to a plane beneath the orbicularis muscle, and implanting at the ciliary implant site an orientated prosthesis implant base having, or adapted to securely receive, a plurality of artificial eyelash hairs, the prosthesis being oriented to replace, restore, or augment eyelashes. The incision is then closed. | 09-18-2014 |
20140379084 | SKIN WEFT AND METHOD FOR MANUFACTURING THE SAME - A skin weft with artificial hair attached thereto to provide various styling options or ample volumetric feeling. The skin weft comprises a stitched portion formed by stitching on a side edge of artificial hair composed of human hair or resin hair, a resin tape welded to a surface of the stitched portion, and a bonding component attached to a surface of the resin tape. The method for manufacturing the skin weft comprises the steps of forming a stitched portion by stitching one side edge of human hair or resin hair arranged and conveyed in the form of a sheet, and supplying a resin tape onto a surface of the stitched portion to form a bonding portion. Automatic mass production is achieved, thereby improving productivity and significantly reducing manufacturing costs. Additional means are unnecessary in the manufacturing process, thereby enabling an unskilled person to perform the task. | 12-25-2014 |
20150374489 | Ciliary Implant, Ciliary Augmentation - A prosthesis for eyelash replacement, restoration, or augmentation includes an implantable base serving a substrate at a ciliary implant site in proximity to a native eyelash line, and a plurality of artificial eyelash hairs secured to the implantable base at intervals along and extending from the implantable base to mimic the look of real human eyelashes. The implantable base may be composed of an absorbable material or a non-reactive, non-absorbable substance and may be curvilinear, rectangular, or round with an annular cross-section in shape. The plurality of artificial eyelash hairs are of a flexible material, preferably composed of a keratin-base or inert fiber, secured, knotted, permanently fixed to the implantable base to mimic native eyelash. A method of eyelash replacement, restoration, or augmentation comprises selecting a ciliary implant site in proximity to a native eyelash line, making an incision corresponding to the ciliary implant site deepened to a plane beneath the orbicularis muscle, and implanting at the ciliary implant site an orientated prosthesis implant base having, or adapted to securely receive, a plurality of artificial eyelash hairs, the prosthesis being oriented to replace, restore, or augment eyelashes. The incision is then closed. | 12-31-2015 |
20220133353 | HAIR TRANSPLANTER HAVING CORE SHAFT CONVEYING PORTION - A hair transplanter includes: a needle channel bundle including a center shaft, and a plurality of needle channels coupled to an outer circumference of the center shaft to be slidable up and down; a first spring configured to push down and move forward one of the plurality of needle channels; and a second spring configured to retract the needle channel, which moves forward, in an upward direction, wherein each of the needle channels includes a body portion having a tubular inner space, a needle coupled to a lower portion of the boy portion, and a core shaft disposed in the tubular inner space to be slidable. | 05-05-2022 |
623150120 | Skin | 31 |
20080281421 | Wound Closure System and Methods - Wound closure systems and methods are provided, containing a porous layer comprising a collagen material; a substantially non-porous synthetic layer contacting the porous layer, the porous layer and substantially non-porous layer capable of providing wound closure; and a transcutaneous component contacting the porous layer and the substantially non-porous synthetic layer. In various embodiments, the transcutaneous component is capable of receiving a cannula, glucose sensor, electrode, prosthesis, chest tube, medical instrument or bone, muscle, blood vessels, nerve, organ or combination thereof. | 11-13-2008 |
20110015739 | SYSTEMS AND METHODS FOR FORMING PATTERNED EXTRACELLULAR MATRIX MATERIALS - An extracellular matrix (ECM)-based scaffold suitable for artificial skin as well as other structures can be formed using a bioreactor fabricated with a pattern that introduces desired structural features, on the microscale and/or nanoscale, to ECM-precursors gelled in the bioreactor. The bioreactor can produce a finely patterned scaffold—over clinically relevant size scales—sufficiently robust for routine handling. Preformed ECM-based scaffolds can also have microscale and/or nano-scale structural features introduced into a surface thereof. ECM-based scaffolds may be formed with well-defined structural features via microetching and/or remodeling via ‘contact degradation.’ A surface-activated pattern can be used to degrade the ECM-based scaffold at contact regions between the pattern and the ECM. The produced ECM-based scaffolds can have structures of dimensions conducive to host tissue ingrowth while preserving the fibrous structure and ligand density of natural ECMs. | 01-20-2011 |
20110098815 | SKIN SUBSTITUTE MEMBRANE, MOLD, AND METHOD OF EVALUATING EXTERNAL PREPARATION FOR SKIN - A skin substitute membrane includes a surface on one side including a groove-shaped depressed portion and a planar portion, the depressed portion having a cross section having a chamfered V-letter shape, the surface having an arithmetic mean roughness Sa of more than or equal to 10 μm to less than or equal to 50 μm. The depressed portion has a width of more than or equal to 50 μm to less than or equal to 500 μm and a depth of more than or equal to 30 μm to less than or equal to 150 μm. A spectral transmittance for light of more than or equal to 290 nm to less than or equal to 400 nm in wavelength is more than or equal to 50% and less than or equal to 100%. | 04-28-2011 |
20110270394 | METHOD AND MEMBRANE FOR SKIN REGENERATION - Skin regeneration or grafting is promoted utilizing a structure including a multi-layer sheet of collagen membrane material which includes a purified collagen barrier sheet material derived from natural collagen-containing tissue, the barrier sheet material including a barrier layer with an outer smooth barrier face and a fibrous face opposite the smooth barrier face. The structure further includes a matrix layer of collagen sponge material adjacent to the fibrous face. The matrix layer of collagen sponge material is resorbed by a body of a subject at a substantially faster rate than the barrier sheet material. | 11-03-2011 |
20120095557 | DERMAL MICRO-ORGANS, METHODS AND APPARATUSES FOR PRODUCING AND USING THE SAME - Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived, having dimensions selected so as to allow passive diffusion of adequate nutrients and gases to cells of the DMO and diffusion of cellular waste out of the cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in the DMO. Some embodiments of the invention provide methods and apparatuses for harvesting the DMO. An apparatus for harvesting the DMO to may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Other embodiments are described and claimed. | 04-19-2012 |
20120109300 | SKIN SUBSTITUTE MEMBRANE, MOLD, AND METHOD OF EVALUATING EXTERNAL PREPARATION FOR SKIN - A skin substitute membrane includes a surface on one side including a groove-shaped depressed portion and a planar portion, the depressed portion having a cross section having a chamfered V-letter shape, the surface having an arithmetic mean roughness Sa of more than or equal to 10 μm to less than or equal to 50 μm. The depressed portion has a width of more than or equal to 50 μm to less than or equal to 500 μm and a depth of more than or equal to 30 μm to less than or equal to 150 μm. A spectral transmittance for light of more than or equal to 290 nm to less than or equal to 400 nm in wavelength is more than or equal to 50% and less than or equal to 100%. | 05-03-2012 |
20120323325 | AUTOLOGOUS IN SITU TISSUE ENGINEERING - A kit that may be used to process autologous skin tissue that is grafted to the patient's wound for in situ growth of new skin tissue may include: a skin collection packet, a skin processing packet, a skin tissue application packet, and a wound preparation packet. | 12-20-2012 |
20130006355 | ARTIFICIAL SKIN - The present invention relates to a method for producing artificial skin, comprising: adding a matrix metalloproteinase inhibitor and a heparanase inhibitor to an artificial skin formation culture medium comprising human epidermal keratinocytes and human dermal fibroblasts, culturing the cells in the artificial skin formation culture medium, and forming artificial skin. | 01-03-2013 |
20130013068 | Acellular Dermal Allografts And Method Of Preparation - A method for preparing a sterilized human acellular dermal allograft where the dermal allograft is sterilized by irradiation and has a greatly reduced bio-burden and enzymatic and antigenic activity. This product line of allografts can be easily used by surgeons in soft tissue replacement or repair and has an extended shelf life, of up to at least about three years. | 01-10-2013 |
20130060335 | Device for cell spraying, manufacturing of the device, method for spraying with the device and a cell suspension sprayed with the device - The invention provides a description of a method and a device suitable for producing a cell suspension spray with living cells, and the produced cell preparation, suitable for grafting to a patient. In contrast to other methods, the spraying is performed through a disposable needle which is inserted into a disposable air tube; which provides a cell distribution avoiding spray nozzles. Small suspension droplets are provided instead of cell nebulization. By using medical grade sterile Luer-lock disposables from medical routine praxis, biocompatibility and easy application is addressed. In applying the method and/or in using the device, cells suitable for grafting to a patient are dispersed in a solution and sprayed with the device for distribution over the recipient graft site. | 03-07-2013 |
20130085570 | FENESTRATOR DEVICE AND RELATED METHODS - Devices, kits and/or methods for, or related to, creating a plurality of openings in a skin graft or skin substitute are described. The devices can have a plurality of perforating elements extending from a perforation component that can be safely held and manipulated by a user. The user can apply sufficient force to the perforating elements against the skin graft or skin substitute to enable the extended ends of the perforating elements to pass through the skin graft or skin substitute as to create openings therethrough. | 04-04-2013 |
20130085571 | COMPOSITION AND METHOD OF PREPARATION OF POLYSACCHARIDE GEL-BASED ARTIFICIAL, BIODEGRADABLE SKIN SCAFFOLDS - An artificial, biodegradable skin scaffold includes a biodegradable polysaccharide hydrogel composition having a Young's modulus of at least about 10 MPa and, preferably, includes an additional biodegradable polysaccharide hydrogel composition with the two biodegradable polysaccharide hydrogel compositions contacting one another and the additional biodegradable polysaccharide hydrogel composition preferably having a Young's modulus of less than about 10 MPa. | 04-04-2013 |
20130103151 | DERMAL MICRO-ORGANS, METHODS AND APPARATUSES FOR PRODUCING AND USING THE SAME - Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for harvesting the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO. | 04-25-2013 |
20130184821 | TREATMENT OF LEG ULCERS USING PLACENTA DERIVED COLLAGEN BIOFABRIC - The present invention provides a method of treating a leg ulcer comprising contacting the leg ulcer with a collagen biofabric. The leg ulcer may be a venous, arterial, diabetic or decubitus (pressure) ulcer. The invention further provides kits comprising one or more pieces of collagen biofabric for the treatment of a leg ulcer. | 07-18-2013 |
20130218274 | SHREDDED TISSUE GRAFTS AND METHODS FOR MAKING AND USING THE SAME - Described herein are shredded tissue grafts composed of one or more placental components. The compositions have numerous medical applications with respect to wound healing and complications associated with wound healing. Methods for making the shredded tissue graft compositions are also described herein. | 08-22-2013 |
20130238092 | Composite for Thermo-Sensitive Cell-Tissue Transplanted Scaffold and Use thereof - A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. The present invention further provides a method for treating a patient with a skin defect, consisting of (a) providing said patient with a composite consisting of a N-isopropylacrylamide (NIPAAm) layer polymerized with a biodegradable layer containing gelatin and a layer of polypropylene (PP) non-woven, wherein a bone marrow derived mononuclear cell with CD45 negative and glycophorin A negative is cultivating on the biodegradable layer; (b) covering said composite on the skin defect of the patient; and (c) treating the composite with water below 25° C. to strip off the layer of polypropylene (PP) non-woven. | 09-12-2013 |
20130289724 | AMNION AND CHORION WOUND DRESSING AND USES THEREOF - An improved wound dressing is described. The wound dressing contains an allograft having at least one layer of human amnion and chorion tissues that has a size and shape appropriate for covering a wound, a base sheet for securing the allograft over the wound, and optionally a support layer to protect the allograft. Methods of preparing the wound dressing and using it in wound healing are also described. The products and methods improve the performance of the wound healing, e.g., by accelerating wound healing, reducing scar formation, inflammation and risk of infection. | 10-31-2013 |
20140067064 | DRIED AND IRRADIATED SKIN EQUIVALENTS FOR READY USE - The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes. | 03-06-2014 |
20140277454 | Absorbent Substrates For Harvesting Skin Grafts - Methods and devices for management of fluids during skin graft transplantation are disclosed. In one aspect of the invention, absorbent substrates for transplanting skin grafts are disclosed having a surface adapted to contact at least one excised skin graft and engage said graft for removal from a donor site; a sealing member at least partially surrounding an absorbent material disposed within the enclosure; wherein at least a portion of the skin-contacting surface is porous and in fluid communication with the absorbent layer to capture fluids. | 09-18-2014 |
20140343676 | Skin Substitute and Wound Dressing with Variable Pore Sizes - An improved skin substitute is presented comprised of a silicone layer backed up with a woven nylon fabric layer, the silicone layer possessing a regular pattern of slits that permit the porosity of the skin substitute to be adjusted by clinicians by means of applying tension to the skin substitute that differentially opens the slits. A variety of therapeutic substances can be applied to the skin substitute to promote healing, including aloe and other medicinal preparations. | 11-20-2014 |
20140350680 | PROCESS FOR MODIFYING THE SURFACE MORPHOLOGY OF A MEDICAL DEVICE - The present invention relates to a process for modifying the surface morphology of a medical device. The modified surface has, among other advantageous properties, an improved capacity for sorption or conjugation of a variety of bioactive agents, the addition of which will turn the medical device into a localized drug delivery system. | 11-27-2014 |
20150018948 | ORBICULAR TISSUE EXPANDER - Provided herein is a tissue stretching device configured for orbicular expansion of a tissue placed therein. Methods of use of the device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods making use of the same. | 01-15-2015 |
20150057751 | ACELLULAR DERMAL GRAFT - An acellular dermal graft is provided. The acellular dermal graft may be useful in minimizing side effects caused after transplantation since an environment favorable for formation of new blood vessels and proliferation of autologous tissues is provided by forming a multi-penetration structure in an acellular dermal tissue, removing a basement membrane layer and/or subjecting corners to slope cutting, and transplantation is stably performed within a short transplantation time due to improved extensibility and flexibility of tissues. The acellular dermal graft may be useful in reducing a time required to recover tissues after transplantation since the transplantation is stably performed due to improved grafting reaction with a host tissue by enhancing uptake of fibroblasts and promoting angiogenic activities. Also, the acellular dermal graft may be useful in maintaining smooth external appearance since hypodermic implantation is easily performed upon transplantation, and the skin at a graft site does not protrude after transplantation. | 02-26-2015 |
20150119985 | FILLER FOR REMOVING WRINKLES - The present invention relates to a filler for removing wrinkles, comprising: a slim and long tubular main body penetrating through the subcutaneous tissue; and a through-hole provided so as to enable the cells of the peripheral tissue of the main body to move to the inside of the main body so as to form a fibrous tissue, the through-hole being formed so as to communicate with a hollow portion formed inside the main body in the longitudinal direction from the outer peripheral surface of the main body. The filler for removing wrinkles according to the present invention is not deformed or moved by the pressure of a skin or external forces after being inserted into the subcutaneous tissue, and can be applied to various body parts having wrinkles, including body parts having deep wrinkles so as to achieve (semi)permanent effects. | 04-30-2015 |
20150119986 | SYSTEM AND METHOD FOR PERFORMING MINIMALLY INVASIVE FACELIFTS - A system for performing minimally invasive facelifts is provided. The system includes a plate having a base having a top surface and an opposing bottom surface. The base has a plurality of through holes formed therein that extends between the top surface and the bottom surface. A plurality of barbs extends outwardly from the bottom surface. At least one anchor screw is adapted to secure the plate to the bone of patients. A method for performing minimally invasive facelifts is also provided. | 04-30-2015 |
20150290359 | ARTIFICIAL DERMIS FOR TRANSPLANTATION AND METHOD FOR PRODUCING SAME - Artificial dermis for transplantation includes a wound contact layer that includes a porous sheet consisting of a biodegradable material, the porous sheet satisfying the following Equation, Equation: X2/X1≦0.8. In the porous sheet, when a line parallel to a wound contact face and a line perpendicular to a wound contact face of equal length are drawn, X1 represents a number of points of intersection between the line parallel to the wound contact face and pore walls; and X2 represents a number of points of intersection between the line perpendicular to the wound contact face and pore walls. | 10-15-2015 |
20150366655 | SKIN PRINTING AND AUTO-GRAFTING - An apparatus and method for the production of substitute skin that advantageously reduces the amount of donor dermal cells needed from non-wound areas of a patient having a wound to be auto-grafted is reduced by using all of the harvested skin cells. A 3D printer is used to construct a wound graft product from the harvested skin cells without wasting any of the harvested skin cells. In a case of an irregularly shaped wound, wastage of harvested skin associated with trimming is avoided. | 12-24-2015 |
20160135946 | PATCH-TYPE ARTIFICIAL SKIN PREPARATION - The present invention addresses the problem of providing an artificial skin preparation which requires no suturing or the like when treating a wound area with a dried collagen vitrigel membrane material as an artificial skin, and also is less likely to cause contamination or the like with an exudate, and is free from the risk of secondary damage by replacement thereof. The artificial skin preparation for solving the problem includes at least an adhesive film, an adhesion-preventing sheet, and a dried collagen vitrigel membrane material in this order, and is characterized in that the adhesion-preventing sheet has a sufficient size for preventing the adhesion of the collagen vitrigel membrane to an adhesive layer of the adhesive film and is attached to the adhesive layer of the adhesive film at a position corresponding to the position of the dried collagen vitrigel membrane material, and the dried collagen vitrigel membrane material is made easily detachable from the adhesion-preventing sheet when the adhesive film is peeled off while fixing and holding the dried collagen vitrigel membrane material on the surface of the adhesion-preventing sheet during attachment. | 05-19-2016 |
20160143726 | Process for Preparing Tissue Regeneration Matrix - The present invention is directed to a process for making a tissue regeneration matrix. The process comprises providing a collagen-glycosaminoglycan-tropoelastin dispersion; freeze-drying the dispersion to provide a porous freeze-dried matrix; and then crosslinking the porous freeze-dried matrix. The present invention is also directed to a tissue regeneration matrix prepared by the process. | 05-26-2016 |
20160166731 | SKIN PRINTING AND AUTO-GRAFTING | 06-16-2016 |
20160250015 | STRETCHABLE ELECTRONICS FOR ARTIFICIAL SKIN | 09-01-2016 |