Class / Patent application number | Description | Number of patent applications / Date published |
606152000 | Connector for nerve endings | 39 |
20090024150 | NERVE GUIDE - The aim of the invention is to provide a nerve guide that allows the axons to develop fairly freely during regeneration. For this purpose, the nerve guide is produced based on a shaped body from a cross-linked, resorbable, gelatin-based material. The shaped body is a tubular hollow body having a wall with an exterior surface and an interior surface, which wall defines a lumen. The nerve guide comprises a semipermeable layer surrounding the lumen. | 01-22-2009 |
20090099580 | METHODS AND APPARATUS FOR ENHANCED GROWTH OF PERIPHERAL NERVES AND NERVOUS TISSUE - A medical device comprises a tubular body having a lumen and a long axis; and a plurality of silk elements laid substantially parallel along the long axis of the lumen of the tubular body. A method of manufacturing the medical device comprises forming the tubular body and introducing the silk elements into the lumen of the tubular body so as to lie substantially parallel along the long axis of the lumen of the tubular body. The device can be used in a method for the regeneration of nerve cells comprising the implantation of a medical device at a site for regeneration of nerves. | 04-16-2009 |
20090209983 | POLYHYDROXYALKANOATE NERVE REGENERATION DEVICES - Nerve regeneration devices are provided with improved rates of axonal regeneration, and methods for their manufacture are also disclosed. The devices are formed from a biocompatible, absorbable polymer, known as poly-4hydroxybutyrate. Growth factors, drugs, or cells that improve nerve regeneration may be incorporated into the devices. The devices are administered by implantation preferably without the use of sutures. In one aspect, the device is in the form of a wrap that can be used easily to capture the severed nerve bundle ends during surgery, and formed into a conduit in situ. If desired, the edges of the wrap can be melted together to seal the conduit, and hold it in place A major advantage of the device is that it does not need to be removed after use since it is slowly degraded and cleared by the patient's body, yet remains functional in situ beyond the time required for nerve regeneration, and helps exclude scar tissue. The device also degrades in a cell-friendly manner, and does not release highly acidic or inflammatory metabolites. Furthermore, the device is flexible, strong, does not crush the regenerating nerve, is easy to handle, reduces surgical time by eliminating the need to harvest an autologous graft, and allows the surgeon to repair the nerve without a prolonged delay. | 08-20-2009 |
20100016874 | APPARATUS AND METHOD FOR CONNECTING TWO ELONGATE BODY TISSUES - An apparatus for connecting two elongate body tissues is described. A flexible outer surface has a first outer end longitudinally spaced from a second outer end. A flexible inner surface has a first inner end longitudinally spaced from a second inner end. A first end aperture is defined by a flexible connection between the first outer end and the first inner end. The first end aperture is configured to accept a first elongate body tissue. A second end aperture is defined by a flexible connection between the second outer end and the second inner end. The second end aperture is configured to accept a second elongate body tissue. The outer and inner surfaces are configured for relative eversion operative to longitudinally shift an instantaneous midpoint of the apparatus with respect to a reference location on the inner surface. A method of using the apparatus is also provided. | 01-21-2010 |
20100023031 | NEURAL GUIDE - A neural guide ( | 01-28-2010 |
20100057116 | POROUS MATERIAL CONDUIT AND METHOD FOR PREPARING THE SAME - The present invention provides a porous material conduit and a method for preparing the same, wherein the porous material conduit includes a porous material basal body and one or more conduit-shaped structures formed in the porous material basal body by laser, and method includes the steps of providing a porous material basal body and injecting a laser beam there into, so as to form a conduit-shaped structure in the porous material basal body to obtain a desired porous material conduit, thereby overcoming the drawback of damages to the porous material basal body caused by an uneven force applied when employing a conventional hole drilling technique. Moreover, a plurality of conduit-shaped structures in a multidirectional intersecting alignment may be easily obtained by adjusting relative displacements and varying the injection angle, of the laser beam with respect to the basal body and of the laser beam. | 03-04-2010 |
20100076465 | FIBRIN-BASED NERVE REPAIR CONDUIT AND METHOD OF PRODUCING THE SAME - A bioresorbable fibrin-based nerve repair conduit produced from tissue glue is disclosed. The nerve repair conduit may be in the form of a sheet or a tube, and may additionally comprise a serine protease, and/or Factor XIII and/or calcium ions. The serine protease is chosen from the group consisting of trombin, plasmin, elastases, and plasminogen activators, or combinations thereof. The nerve repair conduit may moreover be loaded with Schwann cells and/or Stem cells and/or growth factors, for better nerve regeneration. Further, a method of producing the above-mentioned nerve repair conduit is provided, comprising curing fibrinogen and serine protease containing fluids in the form of a fibrinogen-containing tissue glue, in a mould equipped with a central shaft creating a channel in the nerve repair conduit when removed. Moreover, use of a fibrinogen-based tissue glue for the preparation of a fibrin-based nerve repair conduit is described. A method of treating nerve damage by placing a nerve repair conduit according to the invention around at least one nerve stump and allowing the nerve repair conduit to guide the nerve stump during regeneration is also provided. | 03-25-2010 |
20100094318 | METHODS OF MAKING COLLAGEN FIBER MEDICAL CONSTRUCTS AND RELATED MEDICAL CONSTRUCTS, INCLUDING NERVE GUIDES AND PATCHES - The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices. | 04-15-2010 |
20100234863 | NANOFIBROUS CONDUITS FOR NERVE REGENERATION - A hollow fibrous conduit for promoting regeneration of a severed nerve, comprising a first end for coapting the conduit to a first end of a severed nerve and second end for coapting the conduit to a second end of the severed nerve, the hollow fibrous conduit comprising chitosan-poly(caprolactone) fibers. Methods for making the conduit and methods for using the conduit for nerve regeneration. | 09-16-2010 |
20100249811 | METHOD FOR THE MANUFACTURE OF NERVE REGENERATION-INDUCING TUBE - To provide a method for the manufacture of a nerve regeneration-inducing tube being excellent in pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, property of prevention of invasion of outer tissues and leakage resistance. | 09-30-2010 |
20110066169 | METHODS FOR TREATING AN INJURED NERVE PATHWAY - Methods and apparatus are provided for treating an injured or severed nerve pathway, wherein one or more microporous tubes are implanted into the nerve pathway to bridge the injured or severed region. A bioactive matrix including stem cells and nutrients is disposed within the microporous tube to facilitate growth of the stem cells and reestablishment of the sensory and motor conductive pathways through the injured or severed region. The microporous tube protects the bioactive matrix during development of the stem cells, and also retains the end regions in proper alignment during the nerve pathway regeneration. | 03-17-2011 |
20110082482 | Materials and Methods for Nerve Repair - The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of the subject invention comprise one or more chondroitin sulfate proteoglycan (CSPG)-degrading enzymes that promote axonal penetration into damaged nerve tissue. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods. The invention also pertains to kits for nerve repair. | 04-07-2011 |
20110125170 | HYDROGEL-GRAFTED DEGRADABLE NERVE GUIDES - The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve guides and methods for preparation of hydrogel-grafted nerve guides with encapsulated neurotrophic factors and a nanofiber mesh lining the inner surface of the guide. The present invention also provides methods for peripheral nerve repair using these hydrogel-grafted nerve guides. | 05-26-2011 |
20110137328 | Nerve Repair with a Hydrogel and Optional Adhesive - The subject invention provides materials and methods for effective nerve repair. In a preferred embodiment, the subject invention provides nerve repair methods comprising the use of a fibrin glue and a polyethylene glycol (PEG) hydrogel to coapt severed nerve stumps or nerve grafts. | 06-09-2011 |
20110137329 | NERVE REGENERATION EMPLOYING KERATIN BIOMATERIALS - A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery. | 06-09-2011 |
20110152898 | TISSUE ENGINEERED CONSTRUCTS - The present invention relates to a field of biocompatible membranes, tubes and conduits which comprising a photosensitizer which is capable of being crosslinked to form a three dimensional structure which can be implanted into a subject to assist in tissue bonding and nerve maintenance and development. Methods of making such membranes, tubes and conduits and kits comprising them are also described. | 06-23-2011 |
20110245852 | MEDICAL DEVICE - The present invention provides a peripheral nerve growth conduit for peripheral nerve repair, in particular conduits through which peripheral nerves can grow. The conduit includes poly-ε-caprolactone (PCL). Preferably, the inner (luminal) surface of the conduit comprises pits having a depth of 1-4 μm. Suitably, the conduit may also include poly-lactic acid (PLA). The inner surface of the conduit may have been treated with an alkaline composition. The present invention also provides a method for treating a peripheral nerve damage using a peripheral nerve growth conduit including poly-ε-caprolactone (PCL). The present invention also provides a kit for treating a peripheral nerve damage having a peripheral nerve growth conduit including poly-ε-caprolactone (PCL). | 10-06-2011 |
20110276066 | Multichannel collagen nerve conduit for nerve repair - The present invention relates to the fabrication of multichannel nerve conduits for use in the repair of nerve injury. In particular, the invention relates to collagen multichannel nerve conduits which are suitable for use in repair of peripheral nerves. | 11-10-2011 |
20110288569 | NERVE REGENERATION-INDUCING TUBE - The present invention provides a nerve regeneration-inducing tube in which collagen having excellent adhesive property, cell growth property and differentiation inducing property to nerve cells is used as a scaffold for the nerve regeneration. The nerve regeneration-inducing tube is characterized in using the collagen which is made the concentration of sodium chloride contained therein not more than 2.0% by weight or, preferably, 0.1 to 1.5% by weight in a dry state. Purification of collagen is carried out by means of an isoelectric precipitation where the pH is 6.0 or higher and is lower than 10.0. | 11-24-2011 |
20120109167 | NERVE GUIDE CONDUIT CONTAINING CARBON NANOTUBES - The embodiments herein relate to a conduit comprising an insulating material in a form of a tube having an inner surface and an outer surface, the inner surface having carbon nanotubes. | 05-03-2012 |
20120150205 | SILK NANOFIBER NERVE CONDUIT AND METHOD FOR PRODUCING THEREOF - The present invention relates to a silk nanofiber nerve conduit characterized in that fibroin nanofibers having a diameter of 200 to 400 nm, originated from silk fiber, are stacked layer upon layer to form a porous conduit-shape; and a method for producing thereof, more specifically, to a method for producing a silk nanofiber nerve conduit comprising: (Step 1) preparing a fibrous spinning solution; (Step 2) producing a silk nanofiber of conduit-shape by electrospinning the fibrous spinning solution prepared in step 1 into the cylindrical collecting part coated with polyethyleneoxide; and (Step 3) separating a silk nanofiber of conduit-shape produced in step 2 from the collecting part. The silk nanofiber nerve conduit of the present invention has excellent biocompatibility; allows the body fluid to be exchanged inter in and out of conduit through pores of the conduit, as well; has a proper elasticity, tensile strength, and tear strength. Due to these properties, the silk nanofiber nerve conduit of the present invention helps the regeneration of the nerve injury to recover a motor skill and a sensory function, and thus shows an excellent effect of nerve regeneration. Therefore, the silk nanofiber nerve conduit of the present invention can be used in treating a nerve injury instead of an existing synthetic polymeric nerve conduit. | 06-14-2012 |
20120203254 | Allogenic Vessel Nerve Conduit - The present invention relates to a method for repairing a peripheral nerve injury. The method comprises providing an immunologically inactive allogenic vessel at a peripheral nerve injury site and routing nerve tissue through the vessel lumen to bridge the peripheral nerve injury site. | 08-09-2012 |
20120221025 | ELECTROSPUN NERVE GUIDES FOR NERVE REGENERATION DESIGNED TO MODULATE NERVE ARCHITECTURE - Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide. | 08-30-2012 |
20130060266 | NEURAL PROSTHESIS AND METHOD FOR PRODUCING A NEURAL PROSTHESIS - The invention relates to a neural prosthesis, a neural prosthesis for use in the treatment of severed nerves and to a method for producing a neural prosthesis. Said neural prosthesis comprises a coupling element receptacle and at least one coupling element having a first and a second coupling section, wherein the coupling element is fixed by the coupling element receptacle, and wherein the first coupling section can be arranged on a first nerve region and the second coupling section on a second nerve region so that both nerve regions can be coupled by means of the neural prosthesis. | 03-07-2013 |
20130110138 | THREE-DIMENSIONAL SCAFFOLDS, METHODS FOR FABRICATING THE SAME, AND METHODS OF TREATING A PERIPHERAL NERVE OR SPINAL CORD INJURY | 05-02-2013 |
20130184724 | MEDICAL DEVICE - The present invention provides a peripheral nerve growth scaffold including poly ε-caprolactone (PCL) and microgrooves on an inner surface of the scaffold, the scaffold being adapted for use in treatment of damaged peripheral nerves. The microgrooves are suitably arranged as a pattern or array and preferably comprise sloping side walls, which arrangement has been found to provide a favourably environment for nerve and Schwann cell growth and proliferation. Experimental results demonstrate directed and aligned growth, which suitably reduces the rate of formation of neuromas. Embodiments comprising a PCL-PLA blend of the sloping side wall and a groove width greater than the spacing between adjacent grooves has been found to be particularly effective for directed cell growth and proliferation. | 07-18-2013 |
20130190786 | NEURAL IMPLANT - A neural implant comprising spider silk, especially a neural implant consisting of natural spider silk fibres. In particular, the present invention makes available spider silk for use for the production of a pharmaceutical composition whose medical indication is defects in nerves that are to be bridged. Thread-like spider silk is arranged essentially in an axial direction within a sheathing formed of spider silk threads. The sheathing can be knitted, woven, laced or braided of spider silk threads. | 07-25-2013 |
20130331869 | Conductive polymeric composites of polycaprolactone fumarate and polypyrrole for nerve regeneration - A novel electrically conductive polymer composite composed of polycaprolactone fumarate-polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and Dorsal Root Ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in pre-formed scaffolds of PCLF resulting in an interpenetrating network of PCLF-PPy. PCLF-PPy composite materials possess electrical conductivity up to 6 mS cm | 12-12-2013 |
20130345729 | COMPRESSION AND KINK RESISTANT IMPLANTS - A compression and kink resistant tubular implant for nerve repair. The implant includes a tubular biopolymeric membrane and a polymeric supporting filament. Also provided is a shaped compression resistant implant for ridge augmentation in dental surgery. Methods for producing the implants are also provided. | 12-26-2013 |
20140081297 | BIODEGRADABLE NERVE GUIDES - The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve guides and methods for preparation of hydrogel-grafted nerve guides with encapsulated neurotrophic factors and a nanofiber mesh lining the inner surface of the guide. The present invention also provides methods for peripheral nerve repair using these hydrogel-grafted nerve guides. | 03-20-2014 |
20140100591 | METHOD FOR THE MANUFACTURE OF NERVE REGENERATION-INDUCING TUBE - A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution. | 04-10-2014 |
20140163587 | NERVE GUIDE CONDUIT - A nerve guide conduit comprising a first open cover, a second open cover and a connecting portion is provided. The first open cover has a first guiding recess, a first terminal surface and a second terminal surface opposite to the first terminal surface. The first guiding recess is extended to the second terminal surface from the first terminal surface. The second open cover has a second guiding recess, a third terminal surface and a fourth terminal surface opposite to the third terminal surface. The second guiding recess is extended to the fourth terminal surface from the third terminal surface. When the first open cover covers the second open cover, the first guiding recess and the second guiding recess together provide a nerve receiving space. The connecting portion connects the first open cover and the second open cover. | 06-12-2014 |
20140277001 | SYSTEM FOR PROVIDING FLUID FLOW TO NERVE TISSUES - Provided is an apparatus that includes a nerve conduit and a nested manifold for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit and nested manifold, and a conduit for providing fluid communication between the manifold and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue. | 09-18-2014 |
20140336681 | METHODS AND DEVICES FOR CONNECTING NERVES - A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may, for example, facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (e.g., a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time (e.g., at least 1 week). | 11-13-2014 |
20140379009 | IMPLANTABLE NERVE CONDUIT HAVING A POLYMER FIBER SPIRAL GUIDANCE CHANNEL - A nerve guidance conduit includes a spiral structured porous sheet decorated with channels on its surface and electrospun nanofibers in a parallel alignment with the channels and an outer tubular structure including randomly-oriented nanofibers. Such a structure provides augmented surface areas for providing directional guidance and augmented surfaces for enhancing and peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods. To prepare a nerve guidance conduit, porous polymer sheet is prepared by a solvent casting method while using a template of thin rods to form parallel channels on a surface of the sheet. Aligned nanofibers are deposited on the sheet parallel to the channels. The polymer sheet is then wound to form a spiral structure. A dense layer of randomly-oriented nanofibers may be deposited on the outside of the spiral. | 12-25-2014 |
20150032137 | DESIGN OF A CONDUIT FOR PERIPHERAL NERVE REPLACEMENT - A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection. | 01-29-2015 |
20150142026 | THERAPEUTIC ELECTROSPUN FIBER COMPOSITIONS - The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits. | 05-21-2015 |
20160074042 | NEURAL IMPLANT - A neural implant for bridging interruptions or defects within a nerve. The neural implant consists of thread-like spider silk formed from fibers of spider silk arranged around a carrier element. The carrier element consists of thread-like spider silk. The carrier element can carrier element be a plurality of pieces of spider silk arranged in parallel. The thread-like spider silk can be natural or modified spider silk, including chemically modified spider silk. | 03-17-2016 |
20160082149 | PERIPHERAL NERVE GROWTH CONDUIT - The present invention provides a peripheral nerve growth conduit for peripheral nerve repair, in particular conduits through which peripheral nerves can grow. The conduit includes poly-ε-caprolactone (PCL). Preferably, the inner (luminal) surface of the conduit comprises pits having a depth of 1-4 μm. Suitably, the conduit may also include poly-lactic acid (PLA). The inner surface of the conduit may have been treated with an alkaline composition. The present invention also provides a method for treating a peripheral nerve damage using a peripheral nerve growth conduit including poly-ε-caprolactone (PCL). The present invention also provides a kit for treating a peripheral nerve damage having a peripheral nerve growth conduit including poly-ε-caprolactone (PCL). | 03-24-2016 |