Entries |
Document | Title | Date |
20080214986 | GELS WITH PREDETERMINED CONDUCTIVITY USED IN ELECTROPORATION OF TISSUE - Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues. | 09-04-2008 |
20080214987 | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances - A system and method of using a high-aspect ratio microdevice for treating, preventing or ameliorating a medical condition is provided. | 09-04-2008 |
20080214988 | Methods And Devices For Fractional Ablation Of Tissue - Methods and devices for ablating portions of a tissue volume with electromagnetic radiation (EMR) to produce lattices of EMR-treated ablation islets in the tissue are disclosed, including lattices of micro-holes, micro-grooves, and other structures. Also, methods and devices for using the ablated islets are disclosed, including to deliver chromophores, filler, drugs and other substances to the tissue volume. | 09-04-2008 |
20080269665 | CHEMOTHERAPY DELIVERY DEVICE - A system for delivering medicament to a patient is described. In a first embodiment, the system has a positive ion generator having an input and an output, a device for supplying a medicament, the device in fluid communication with the input, and a nebulizing catheter in fluid communication with the output, the nebulizing catheter configured to receive medicament ionized by the positive ion generator and to deliver the medicament to the patient. In another embodiment, the system has an intracorporeal catheter in fluid communication with the output, the intracorporeal catheter configured to receive medicament ionized by the positive ion generator and to deliver the medicament to the patient. In yet another embodiment, the system has a nebulizing catheter having an input and an output, a device for supplying a medicament, the device in fluid communication with the input, and a positive ion generator in fluid communication with the output, the positive ion generator configured to receive medicament nebulized by the by the nebulizing catheter and to deliver the medicament to the patient. | 10-30-2008 |
20080269666 | Microneedles and Methods for Microinfusion - Methods and devices are provided for delivering a drug to or withdrawing a fluid from a biological tissue, such the skin, sclera, cornea, and conjunctiva. One method includes the steps of inserting at least one microneedle into the biological tissue; partially retracting the at least one microneedle from the tissue; and then delivering at least one drug formulation into the biological tissue via the partially retracted at least one microneedle. The microneedle deforms and penetrates the biological tissue during the insertion step, and the retraction step at least partially relaxes the tissue deformation while maintaining at least part of the tissue penetration, facilitating drug delivery or fluid withdrawal. | 10-30-2008 |
20080287857 | Device and method for single-needle in vivo electroporation - Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single-needle electrode which provides for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue | 11-20-2008 |
20080287858 | Microneedle Arrays and Methods of Use Thereof - A method of treating a patient with a microneedle array having an active agent disposed on at least a portion of one or more of the microneedles, wherein the array with active agent is characterized by a first optical response when probed with a selected incident light spectrum. The array with active agent is applied to a skin surface, optionally allowed to remain on the skin surface for a specified time, and removed. The used array is probed with the selected incident light spectrum, a second optical response is sensed, and the difference between the first optical response and the second optical response is determined and compared to a predetermined threshold value. | 11-20-2008 |
20080287859 | Method and Apparatus to Monitor Patients and Treat with Intraosseous Fluids - Automatic external defibrillator apparatus may be provided for use in cooperation with an intraosseous apparatus. Apparatus and methods may also be provided to execute protocols calling for external defibrillation and drug delivery. The disclosure provides a medical apparatus including two electrodes, a processor, a display, a driver, a drug delivery slot, a drug delivery port, and a voltage source. The two electrodes may include an attachment operable to releasably connect the two electrodes to the patient. The processor may be operable to collect and analyze a rhythm associated with the patient's heart from the two electrodes. The display may be operable to communicate instructions to a user. The driver may be operable to insert an intraosseous device into a bone and associated bone marrow of the patient. The drug delivery slot may be operable to receive a drug. The drug delivery port may be operable to communicate the drug from the drug delivery slot to the patient via the intraosseous device. The voltage source may be operable to deliver an electric shock to the patient via the two electrodes. | 11-20-2008 |
20080294086 | Method and apparatus for delivering oxygen and/or other gases to tissue - A system comprising: a hollow tube having a distal end, a proximal end, and a lumen extending between the distal end and the proximal end; at least a portion of the tube comprising a porous membrane; and a gas-rich perfluorocarbon solution incorporated in the porous membrane; wherein the porous membrane has a porosity in the range of 0.001-200 microns, in order that: (i) the gas-rich perfluorocarbon solution is effectively incorporated into the porous membrane; and (ii) when the porous membrane is positioned in blood, the gas-rich perfluorocarbon solution elutes out of the porous membrane, in aggregations small enough to prevent the creation of embolisms in the blood, with the elution of the gas-rich perfluorocarbon solution into the blood varying between minutes and several hours, depending on the temperature and the hemodynamics of the blood. | 11-27-2008 |
20080300530 | STIMULATING CATHETER - An apparatus for delivery of a substance to an anatomical region in a body can include a catheter comprising a catheter body, and one or more electrically conductive elements supported by the catheter body and in electrical communication with one or more sources of electrical stimulus. The catheter body can comprise a lumen therein, a substantially closed distal end, and an infusion section configured to permit fluid to pass through the catheter body and that can have a length that is less than or equal to the length of the catheter body. In some embodiments, the apparatus can comprise a coiled member positioned within the lumen of the catheter body. The coiled member can comprise adjacent coils and can permit the uniform flow of the substance through one or more holes formed in the catheter body. | 12-04-2008 |
20080319373 | Compound Delivery Tube - A tube for selective administration of a compound. | 12-25-2008 |
20090005724 | Device and Method for Delivery of a Physiologically Active Substance Depending on a Measured Physiological Parameter | 01-01-2009 |
20090018486 | Diagnosis and treatment of vericocele and prostate disorders - A method for forestalling or therapy, at least partially, of BPH or prostate cancer comprising identifying a reflux of venous blood to the prostate and impeding the reflux by treating veins effecting or conveying the reflux, and related apparatus and kit. | 01-15-2009 |
20090018487 | Catheter-Based, Dual Coil Photopolymerization System - A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes an inner catheter received within an outer catheter and a fluid channeling structure mounted on the catheters with its proximal end attached to the outer catheter and its distal end attached to the inner catheter. The fluid channeling structure includes an elastomeric sleeve sandwiched between an inner elastic coil and an outer light emission coil. Light emission coil loops are interspaced with elastic coil loops. The light emission coil has a smaller diameter than the elastic coil, drawing the elastomeric sleeve down between loops of the elastic coil to form a helical channel. The coils and sleeve are stretched to provide a narrowed crossing profile for delivery, and are contracted at a treatment site to form a helical cavity between the sleeve and the vessel wall within which to perform interfacial photopolymerization. | 01-15-2009 |
20090030364 | Electroporation gene therapy gun system - A cartridge for administration of a bioactive agent may include a plurality of chambers, including at least a first chamber and a second chamber. Each of the chambers may contain a component of a composition to be administered to a tissue site of a subject. For example, the first chamber may contain the bioactive agent and the second chamber may contain a liquid for suspending the bioactive agent prior to administration to the tissue site. An apparatus for administering or delivering a bioactive agent may include the cartridge and may further include an energy source for providing an electrical pulse to the tissue site. The apparatus may further cause mixing of the bioactive agent with the liquid in the cartridge. For example, the apparatus may impact the cartridge to result in mixing of the bioactive agent with the liquid. A method for combining a bioactive agent with a liquid forms a composition for delivering to a tissue site. | 01-29-2009 |
20090030365 | Transdermal Drug Administration Apparatus Having Microneedles - It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device ( | 01-29-2009 |
20090036823 | Fluid flowing device and method for tissue diagnosis or therapy - A device and method for safely securing a multilumen device to a tissue, organ or solid tumor within the body of a human during a diagnostic or therapeutic procedure is described. The device is capable of securing the tumor by touching or piercing its surface and providing a coolant to the distal tip. Cooling the tip forms a cryogenically induced region that tightly binds the tip to the tumor, temporarily sealing the entry-track of the instrument. The device further provides at least one injecting/aspirating lumen that can dispense or aspirate a fluid within the tumor. Such construction allows injecting part or whole volume of the tumor while the cryogenically induced bond prevents back-flow of the injected substances through the entry-track. | 02-05-2009 |
20090043245 | DEVICE FOR ADMINISTERING AN INJECTION AND METHOD OF USING SAME - Device for administering an injection is generally discussed herein with particular discussions extended to devices for stimulating a cavity below the skin and administering a dosage in the stimulated cavity and method of using the same. The dosage can be medication for health and/or cosmetic treatments. The device includes a housing and a needle mounted thereto. A vacuum source is in communication with the housing for creating a vacuum inside the housing while a power source is in communication with the needle for supplying current to the needle. The combination current and vacuum stimulates a cavity for injection. A vacuum source may also be used to advance a piston to discharge medicament from a needle mounted on a syringe. | 02-12-2009 |
20090043246 | Magnetic Surgical Device to Manipulate Tissue in Laparoscopic Surgeries Performed with a Single Trocar or Via Natural Orifices - The present invention is related to surgical instruments incorporating the usage of magnets for application in minimally invasive surgery to perform abdominal surgery with a single incision through the navel which is the most widely used, this incision can also be done through some natural orifice like the vagina, mouth, etc. | 02-12-2009 |
20090043247 | Method and device for collagen growth stimulation - The invention provides an applicator for skin treatment having one or more RF electrodes. An article is located between the electrodes, such as a roller or flexible belt containing one or more protruding pins electrically isolated from the RF electrodes. The invention also provides a system for skin treatment comprising the applicator of the invention and a control unit. The invention further provides a method of treating skin disorders in which a section of the skin is heated while, essentially simultaneously, piercing one or more holes in the heated section of the skin. The method of the invention may be used, for example, in collagen remodeling. | 02-12-2009 |
20090076438 | Method for treating a sphincter - A method for treating a sphincter provides a polymer material having a liquid state. The method also provides a catheter having a distal end, a tissue piercing device carried by the distal end, and an energy delivery device coupled to the tissue piercing device. The tissue piercing device has a lumen. The method introduces the catheter into an esophagus and pierces an exterior sphincter tissue surface within with the tissue piercing device. The method advances the tissue piercing device into an interior sphincter tissue site and conveys the polymer material while in a liquid state through the lumen into the interior sphincter tissue site. The method delivers energy to the tissue piercing device to transform the polymer material into a less liquid state within the interior sphincter tissue site, to thereby remodel the sphincter. | 03-19-2009 |
20090082713 | METHOD OF ENHANCING IONTOPHORETIC DELIVERY OF A PEPTIDE - The present invention provides methods for the administration of a peptide to a body surface of the patient comprising treating said body surface by microporation and iontophoretically administering the peptide to the body surface. The present invention also encompasses a method of transdermally administering a peptide to the skin of a patient comprising treating the skin with microporation and iontophoretically administering said peptide to the skin. In one embodiment, the body surface or skin is microporated using one or more microneedles. | 03-26-2009 |
20090082714 | Systems and methods for treating superficial venous malformations like spider veins - Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a light-reactive agent, e.g., verteporfin, at or near an inner wall of a vein. The systems and methods activate the light-reactive agent by applying non-thermal light energy at a wavelength that activates the light-reactive agent to cause localize injury to the inner wall of the vein. | 03-26-2009 |
20090088680 | OPTICAL TISSUE INTERFACE METHOD AND APPARATUS FOR STIMULATING CELLS - In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells. | 04-02-2009 |
20090099501 | Spinal Cord's Epidural Space Detection By Using Fiber Optic Technology - The present invention provides a device and a method for effectively processing epidural anesthesia by providing the needle-localization information in real time. The idea of this invention is derived from the concept that different tissues due to their different composition have different optical properties, such as absorbance and reflection, so we can discriminate the tissue types where the needle reaches by their distinctive optical properties. In this device, the inner solid needle of the puncture needle used before is replaced by a hollow needle which filled with optical fibers, and the distal end of those optical fibers are connected with two light sources of different wavelengths and a light analyzer. Thus, while qualifying and comparing the optical properties of those tissues, these device and method can be very helpful during epidural anesthesia and also reduce the risk of the surgery. | 04-16-2009 |
20090099502 | Microneedle Device And Transdermal Administration Device Provided With Microneedles - The present invention provides a microneedle device having a coating, which is effective even with a low molecular weight active compound and can sustain the effect of the drug for a long period of time, and a transdermal drug administration apparatus with microneedles. The microneedle device ( | 04-16-2009 |
20090131854 | Methods and Devices for Thermally Degrading Bacteria and Biofilm - Described herein are various implantable devices that include a heat generating element for degrading bacterial. In particular, the device can include a catheter having a heat generating element proximate to a distal end of the catheter for heating an outer surface of the catheter. | 05-21-2009 |
20090131855 | APPARATUS AND METHODS FOR DRUG RELEASE IN TISSUE ABLATION PROCEDURES - Tissue ablation probes and methods for treating tissue are provided. The tissue ablation probe comprises an elongated probe shaft, at least one electrode carried by the distal end of the probe shaft, and a pharmaceutical agent carried by the probe shaft. The pharmaceutical agent may be disposed on the electrode(s), the probe shaft, or a releasable portion associated with the electrode or the probe shaft. A method for treating tissue comprises introducing a tissue ablation probe to a tissue site, operating the tissue ablation probe to ablate tissue at the tissue site, and releasing a pharmaceutical agent from the tissue ablation probe at the tissue site. | 05-21-2009 |
20090171265 | Catheter-Based, Dual Balloon Photopolymerization System - A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter having a first inflatable member and a guidewire having a second inflatable member. The catheter has an extended tip distal to the first inflatable member that includes multiple perfusion ports. A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel. The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil. | 07-02-2009 |
20090204060 | Flexible Application Device for the High-Frequency Treatment of Biological Tissue - The invention concerns a flexible application device ( | 08-13-2009 |
20090216177 | CATHETER-TYPE IONTOPHORESIS DEVICE - A catheter-type iontophoresis device is adapted to cause a drug solution to permeate into a cancer site or the like of a digestive organ on a pinpoint basis by iontophoresis. | 08-27-2009 |
20090254019 | ELECTRODE INTRODUCER DEVICE - An electroporation device | 10-08-2009 |
20090259167 | METHODS AND COMPOSITIONS FOR DOSE-DEPENDENT PHOTODYNAMIC THERAPY OF DISORDERS - The invention provides methods and compositions for treating a tissue disorder in a subject by parenterally administering a solution of aminolevulinic acid (ALA) or a derivative thereof that is not greater than 1.0 percent by weight into a local subcutaneous or dermal region of the subject; and administering high fluence light to said bodily area to produce a phototoxic species in said local region, thereby treating a tissue disorder in the subject. | 10-15-2009 |
20090275878 | Steerable Catheter Device and Method for The Chemoembolization and/or Embolization of Vascular Structures, Tumours and/or Organs - The steerable catheter comprises a flexible tube, inside of which different conducts are arranged: one or more conducts for drug administration, vacuum conducts associated with different radiofrequency electrodes, conducts for the conductive wires that conducts the radiofrequency energy to the distal end of the catheter, conducts for the fibre optic cable/s that conducts the laser energy to the distal end of the catheter, a guiding wire for the catherization, and another components; the steerable catheter being connected from the proximal end to a energy unit and other pressure and/or dosing devices; and the steerable catheter optionally including an inflatable balloon to help occluding the vessel; and it also incorporates one or two electrode/s or conductive layer/s in the distal end of the catheter; the objective of the steerable catheter being the obtaining of better results in the embolization and/or chemoembolization treatments. | 11-05-2009 |
20090281477 | ELECTROPORATION DEVICE AND METHOD - Disclosed herein are methods and devices configured for pulsed voltage ablation that have two or more voltage delivery regions separated along a probe by electrically insulating regions. The electrically insulating regions are of sufficient lengths to allow the voltage delivery regions to be oppositely energized for delivering voltage pulses to treat cells within a predetermined ablation volume that can be delineated through representations indicating pulsed voltage ablation thresholds for cells. | 11-12-2009 |
20090287140 | ELECTRICAL STIMULATION AND INFUSION INTRODUCER ASSEMBLY - An electrical stimulation and infusion introducer assembly is provided for connection to an electrical electrode/electrode. The electrode extends through the lumen of an introducer needle of the introducer assembly. The introducer assembly includes a side port for introduction of liquids through the introducer needle without having to remove the electrode. The side port communicates with the central passageway of the introducer assembly, and the central passageway in turn communicates with the lumen of the needle. | 11-19-2009 |
20090287141 | Device and method for delivering therapeutic agents to an area of the body - A device, system and method deliver an agent to a soft mass, such as an area of the body, and more specifically the brain. One aspect includes creation of one or more channels, tunnels or grooves in tissue using a relatively small diameter, minimally-invasive stylet and then removing the stylet prior to infusion. The stylet-created channels become paths of increased hydraulic conductivity, through which the infusate will tend to flow and produce a predictable infusion pattern. Infusate will be carried into these channels with relatively low resistance, and then infuse outward from these channels into the surrounding tissue. By carefully positioning these channels, one can control and modify the preferred paths and duration of distribution. | 11-19-2009 |
20090299269 | VASCULAR STIMULATION TO AID INTRAVASCULAR CELL REPLACEMENT THERAPY - A system and method are described involving the use of a cell delivery catheter that incorporates a stimulating electrode to promote vasodilation prior to injection of cells at a target location within a blood vessel. The vasodilation may be produced locally and/or distally from the target location near the target organ. The technique may be applied not only to intra-coronary injection of cells to treat heart disease but to injection of cells in any blood vessel that feeds a target organ. | 12-03-2009 |
20090312690 | SELECTIVE PERIPHERAL NERVE PLEXUS IMPLANTABLE INFUSION DEVICE AND METHOD - The present invention relates to a closed system and method for selectively infusing anesthetics into a peripheral nerve or plexus. A method of providing long term pain management is disclosed herein. In the method, a catheter is surgically implanted to create an infusion site at a peripheral neural structure. An implantable pump and reservoir are surgically implanted in subcutaneous tissue. The pump is then operated to deliver a predetermined dosage of medication through the catheter into the infusion site, whereby pain management is provided. | 12-17-2009 |
20090318850 | LEAKAGE-RESISTANT TISSUE TREATMENT APPARATUS AND METHODS OF USING SAME - Apparatus and methods for treating skin conditions that deliver high frequency energy to a patient's tissue. The apparatus has a treatment tip configured to be removably coupled with a handpiece and a conduit inside the handpiece. The treatment tip includes an electrode configured to deliver the high frequency energy to a region of the tissue, a channel for circulating heat transfer fluid proximate to the electrode, and an inlet passage to the channel. The conduit includes a tubular sidewall with a lumen used to transfer the heat transfer fluid from the handpiece to the inlet passage of the treatment tip. When the treatment tip is coupled to the handpiece, a septum covering the inlet passage is configured to be pierced by the conduit to define an opening for coupling the conduit with the inlet passage. When the treatment tip is removed from the handpiece, the septum substantially seals the opening. | 12-24-2009 |
20090326439 | HIGH PRESSURE PRE-BURST FOR IMPROVED FLUID DELIVERY - A needle with multiple injection ports is used in connection with a high-pressure injection system to infuse a treatment solution into a treatment area below the dermis of the skin. The needle has multiple tines that extend outwardly from the injection ports while inside the treatment area to disrupt tissue in the treatment area and to create multiple pathways of infusion. The tines are withdrawn and the needle is partially withdrawn, and solution is injected from the needle into the treatment area at high pressure to infuse the tissue within the treatment area. The burst, infusion, and a treatment such as an energy or third solution may be interleaved and repeated multiple times. | 12-31-2009 |
20100030130 | PHARMACEUTICAL INTERVENTION FOR MODULATION OF NEURAL PLASTICITY - A stimulating medical device. The stimulating medical device comprises: a stimulating assembly implantable proximate to a recipient's neural system, the assembly having at least one agent delivery port and a plurality of electrical contacts; an electrical stimulation controller configured to generate electrical stimulation signals for application the neural system via one or more of the plurality of electrical contacts; a pharmaceutical agent source configured to provide a plasticity modulating agent to the at least one delivery port for application to the neural system; and a pharmaceutical agent controller configured to control one or more of the pharmaceutical agent source and the at least one delivery port to cause selective application of the plasticity modulating agent to the neural system to at least one of reinforce and activate one or more neural pathways within the system. | 02-04-2010 |
20100030131 | SYSTEMS AND METHODS FOR ANESTHETIZING EAR TISSUE - A system and method for use in iontophoretic anesthesia of a tympanic membrane are disclosed. The system generally includes an earplug and an electrode device. The earplug includes at least one sealing member for sealing the earplug in an ear canal. The method involves using the system on a human or animal subject. | 02-04-2010 |
20100056985 | ELECTROACTIVE POLYMER ACTIVATION SYSTEM FOR A MEDICAL DEVICE - An activation circuit for selectively providing an electrical current to one or more electroactive polymers (EAPs) in a medical device is disclosed. The activation circuit may include a sensor for sensing a measure related to a parameter of an elongated member and/or a balloon of the medical device. The electrical current may be provided to the one or more EAPs according to the sensed parameter of the elongated member and/or the balloon of the medical device. In some cases, the activation circuit may include a comparator for comparing the sensed measure to a threshold to determine when the electrical current is applied to the EAPs. The parameter may be a pressure, a fluid flow, a temperature, and/or other suitable parameter. | 03-04-2010 |
20100069824 | Photodynamic hyperthermic chemotherapy of cancer and therapeutic system therefor - A photodynamic hyperthermic chemotherapy of cancer comprising topically injecting a photosensitive dye agent, specifically indocyanine green, in the form of an acidic liquid formulation to a tumor or cancer tissue, or a surgically removed site thereof of a patient, and irradiating the tissue or site with light having such an output wavelength that the photosensitive dye agent absorbs the light and generates heat; and an apparatus and a system for photodynamic hyperthermic chemotherapy of cancer comprising a light source and a probe having a light introducing portion capable of topically irradiating a tumor or cancer tissue or a surgically removed site thereof of a patient with light derived from the light source by a continuous wave or a pulse wave at an output wavelength of 600 to 1600 nm and an output of 5000 mW or more. | 03-18-2010 |
20100081987 | Vacuum-Stabilized Ablation System - Cardiac ablation systems include vacuum-stabilized, irrigated ablation devices that have ablating elements capable of providing regions of relatively low pressure to maintain the ablating element in a stable position relative to the tissue, or minimize relative movement of the ablating element relative to the tissue. The ablation elements have integrated structures for vacuum-stabilization. The devices also include one or more electrodes for both orienting the ablating element as well as for diagnostic purposes. | 04-01-2010 |
20100121256 | Implantable and Refillable Drug Delivery Reservoir - Implantable drug delivery apparatuses and methods are described. An input port septum receives a therapeutic drug. An implantable delivery catheter holds a volume of the therapeutic drug and includes a proximal end in fluid communication with the input port septum, a distal end including an output septum for removing fluid from the catheter, and a drug permeable surface for diffusion of the therapeutic drug into nearby tissue. | 05-13-2010 |
20100125238 | Iontophoretic Therapeutic Agent Delivery System - A system for delivering one or more therapeutic agents contained on or within a delivery segment through a passageway, e.g., a blood vessel, for treatment of a localized region of the passageway, or for treatment of region adjacent to the localized region of the passageway, is provided. | 05-20-2010 |
20100125239 | Selective Drug Delivery In a Lumen - Methods and systems are disclosed for selective drug or fluid delivery in a lumen through a coating or fluid delivery channels. One system includes an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having a radially expandable balloon near the distal end and an energy delivery portion proximate the balloon for transmission of energy, a thermally changeable coating having a releasable drug coupled to the balloon, the thermally changeable coating being oriented to be urged against the body tissue when the expandable balloon expands and an energy source operatively coupled to the energy delivery portion configured to energize the energy delivery portion to heat and liquefy the thermally changeable coating to release the drug to the body tissue. | 05-20-2010 |
20100130912 | Patches and methods for the transdermal delivery of a therapeutically effective amount of iron - Embodiments of the invention provide patches for the transdermal delivery of iron-containing compositions to an individual suffering from an iron deficiency. Many embodiments provide an iontophoretic patch for the transdermal delivery of a therapeutically effective amount of iron. The patch comprises an electrode and a reservoir containing a composition comprising ionic iron for the delivery of the therapeutically effective amount of iron. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a therapeutically effective amount of iron to an individual suffering from one more forms of iron deficiency including iron deficiency anemia. Such methods can be used for treating and/or preventing the iron deficiency. The amount of delivered iron can be adjusted depending upon various treatment parameters such as patient weight and type and amount of iron deficiency. | 05-27-2010 |
20100130913 | INTEGRATED CATHETER AND PULSE GENERATOR SYSTEMS AND METHODS - Disclosed herein, among other things, is a system for providing pacing during revascularization. An embodiment of the system includes an angioplasty or stent delivery catheter system having a catheter, a balloon and an inflation device adapted to inflate and deflate the balloon for delivery of a stent. The embodiment also includes a programmable pulse generator and at least one electrode integrated with the angioplasty catheter system, where the pulse generator is connected to the electrode. In various embodiments, at least one integrated sensor is connected to the angioplasty catheter system. The sensor is adapted to sense a parameter indicative of flow restoration and trigger the pulse generator to begin pacing based on the parameter. | 05-27-2010 |
20100168647 | NON-CONTACT ELECTRODE BASKET CATHETERS WITH IRRIGATION - Catheter systems and methods are disclosed. An exemplary catheter includes an outer tubing housing and an inner fluid delivery tubing, the inner fluid delivery tubing having at least one fluid delivery port. The catheter also includes a deployment member movable axially within the inner fluid delivery tubing. A plurality of splines are each connected at a proximal end to the outer tubing and at a distal end to deployment member. A seal is provided between the outer tubing and the inner fluid delivery tubing. A gasket is provided between the deployment member and the inner fluid delivery tubing. Both the seal and the gasket are configured to prevent blood or other fluid from ingressing into the outer tubing. | 07-01-2010 |
20100174225 | DRUG DELIVERY DEVICE - The present disclosure presents systems, devices and methods for injection of drugs, substances and/or chemicals to a patient and for improving their effectiveness once they are injected are disclosed. Additional treatment can be applied to a tissue region on the patient into which a drug (e.g., insulin) is injected, to expose the tissue region to various forms of energy or a substance to improve the drug's pharmacokinetic and/or pharmacodynamic profile. | 07-08-2010 |
20100174226 | METHOD AND APPARATUS FOR THE ULTRASONIC CLEANING OF BIOFILM COATED SURFACES - To treat body surfaces, such as the sinuses, which are coated with biofilms, the surface is irrigated and suctioned with a fluid which may contain a biocide or other chemical agent for disrupting the biofilm while ultrasonic energy is applied to the fluid barrier formed over the biofilm. Action of the fluid enhanced by the ultrasonic energy tends to remove sections of biofilm which are suctioned out of the site. An electrical field may also be applied to the biofilm to enhance the disruptive action. Apparatus for practicing this method to treat chronic rhinosinusitis comprises an elongated tube adapted to be inserted into sinus cavities through the nose or mouth. The tube includes a first lumen which feeds an irrigating fluid containing biocides and/or biofilm-disruptive chemicals to the treatment site and a second lumen which suctions fluid from the site. An ultrasound horn extends through the tube and its distal end introduces ultrasonic energy into the fluid layer overlying the biofilm. In an alternative embodiment, the tube includes a pair of electrodes which establish an electric field across the biofilm, accelerating degradation. | 07-08-2010 |
20100191173 | TREATMENT SYSTEM FOR SURGERY AND CONTROL METHOD OF TREATMENT SYSTEM FOR SURGERY - A treatment system for surgery includes: a handpiece driving apparatus for supplying electric energy to a handpiece, the handpiece including a treatment portion insertable into a body cavity; a perfusion apparatus for perfusing liquid in the body cavity, the perfusion apparatus being capable of adjusting pressure in the body cavity; and a control circuit for controlling the pressure in the body cavity to a different level in conjunction with an output state of the handpiece driving apparatus and changing a flow rate of the perfusion liquid. | 07-29-2010 |
20100191174 | HAND-HELD ELECTRICAL STIMULATION DEVICE - Apparatuses and methods for the safe and efficient electrical stimulation of tissue. The apparatuses of the present invention are preferably hand-held and are capable of providing electrical waveforms that are effective in promoting wound healing, improving circulation, stimulating peripheral nerves, administering pharmaceutical compounds via electrophoresis, and electroporating DNA into tissue. The present invention also generally contemplates the safe and efficient transfection of DNA into mammalian tissue via electroporation. Particularly, apparatuses of the present invention are useful in the delivery of DNA vaccines and in gene therapy. The present invention also preferably provides for the direct measurement of in vivo tissue resistance. Tissue resistance measurements may then be used to adjust stimulation intensity during electroporation or electrostimulation, so as to avoid damaging tissue during operation of the unit. | 07-29-2010 |
20100191175 | Thrombolysis Catheter - A thrombolysis catheter apparatus is disclosed comprising: (a) an elongated thrombolysis catheter portion comprising a plurality of independently controllable electroactive polymer actuators, which provide a curvature to the thrombolysis catheter based upon received control signals; (b) a control unit coupled to the plurality of actuators and sending the control signals to the plurality of actuators; and (c) an occlusion removal device. Also disclosed is a method of treating an arterial occlusion by advancing the thrombolysis catheter portion through the arterial vasculature of a patient to a position proximate the occlusion, while controlling the shape of the thrombolysis catheter portion using the control unit. The occlusion is then removed using the occlusion removal device. | 07-29-2010 |
20100198135 | SYSTEMS AND METHODS FOR ANESTHETIZING EAR TISSUE - A system and method for use in iontophoretic anesthesia of a tympanic membrane are disclosed. The system generally includes an earplug and an electrode device. The earplug includes at least one sealing member for sealing the earplug in an ear canal. The sealing member includes microholes which vent fluid above a certain pressure threshold. A headset may connect the earplug to a second earplug. The method involves using the system on a human or animal subject. | 08-05-2010 |
20100204639 | DIAGNOSIS AND TREATMENT OF VARICOCELE AND PROSTATE DISORDERS - A method for forestalling or therapy, at least partially, of BPH or prostate cancer comprising identifying a reflux of venous blood to the prostate and impeding the reflux by treating veins effecting or conveying the reflux, and related apparatus and kit. | 08-12-2010 |
20100204640 | MEDICAL DEVICE, IN PARTICULAR FOR ELECTROPORATION TREATMENT - A medical device, in particular for electroporation treatment, characterized by having:
| 08-12-2010 |
20100210997 | Medical Device for Placement of Continuous Regional Anesthesia Catheters - A medical device for placement of regional anesthesia catheters. The device comprises a hollow shaft needle, a plunger attached to the posterior end of the needle, a housing dimensioned so that plunger can slide inside the housing with friction, a regional anesthesia catheter preloaded inside the needle, a protective cover sheath covering the catheter, and a catheter adaptor attached to posterior end of the sheath and the catheter. The medical device allows a practitioner to quickly and effectively place a regional anesthesia catheter inside an organism without the use of an assistant, and with minimal risk of contaminating the catheter before it enters the organism's body. At the end, the needle is withdrawn inside the housing and disposed. | 08-19-2010 |
20100228182 | DISSECTION HANDPIECE AND METHOD FOR REDUCING THE APPEARANCE OF CELLULITE - A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes. | 09-09-2010 |
20100262068 | Method for creating an autologous radiofrequency capsule for containing filling solutions - A method for creating an autologous radiofrequency capsule for containing filling solutions, whose particularity is that it comprises the combined use of bipolar radiofrequencies and of filling or bio-revitalizing solutions based on hyaluronic acid or similar products. | 10-14-2010 |
20100262069 | Photodynamic Bone Stabilization Systems and Methods for Reinforcing Bone - Photodynamic bone stabilization systems are disclosed herein. In an embodiment, a photodynamic bone stabilization system includes a catheter having an elongated shaft with a proximal end adapter, a distal end releasably engaging an expandable portion, and a longitudinal axis therebetween; a light-conducting fiber configured to transmit light energy to the expandable portion; a light-sensitive liquid monomer comprising an initiator, wherein the initiator is activated when the light-conducting fiber transmits the light energy to initiate polymerization of the light-sensitive liquid monomer; and a cooling medium configured to control polymerization temperature, wherein the catheter comprises an inner void sufficiently designed to pass the light-sensitive liquid monomer into the expandable portion, and wherein the catheter comprises an inner lumen sufficiently designed to pass the light-conducting fiber into the expandable portion and configured to circulate the cooling medium. | 10-14-2010 |
20100268151 | Intracranial Implant Emitting Light Between 450 nm and 600 nm - An intracranial implant emitting light having a wavelength between blue and yellow light | 10-21-2010 |
20100274178 | Fluid flowing device and method for tissue diagnosis or therapy - A device and method for safely securing a multilumen device to a tissue, organ or solid tumor within the body of a human during a diagnostic or therapeutic procedure is described. The device is capable of securing the tumor by touching or piercing its surface and providing a coolant to the distal tip. Cooling the tip forms a cryogenically induced region that tightly binds the tip to the tumor, temporarily sealing the entry-track of the instrument. The device further provides at least one injecting/aspirating lumen that can dispense or aspirate a fluid within the tumor, and an outer sheath or guide. Such construction allows injecting part or whole volume of the tumor while the cryogenically induced bond prevents back-flow of the injected substances through the entry-track. | 10-28-2010 |
20100280433 | PROSTATE GLAND ELECTROCHEMICAL-THERAPEUTIC DEVICE - A prostate gland electrochemical-therapeutic device is provided. The prostate gland electrochemical-therapeutic device includes a probe unit and an electrode unit. The probe unit is adapted for introducing a saline solution into a patient's prostate gland. The electrode unit then conducts an electrochemical reaction on the saline solution introduced in the prostate gland to generate a strong acid solution and/or a strong alkaline solution for curing the prostate gland thereby. | 11-04-2010 |
20100298762 | Methods and Devices for Improved Efficiency of RNA Delivery to Cells - The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided. | 11-25-2010 |
20100318019 | ELECTROPHYSIOLOGY DEVICES EMPLOYING ELECTRICALLY CONDUCTIVE POLYMER CONDUCTORS AND METHODS OF MANUFACTURING SUCH DEVICES - A medical tubular body that may be used in an implantable medical lead, a catheter, a sheath and introducer is disclosed herein. The medical tubular body may include a tubular layer formed of an electrically insulating polymer and an electrically conductive polymer strip imbedded in and longitudinally extending through the insulating polymer. | 12-16-2010 |
20100318020 | ELECTROCHEMICAL THERAPEUTIC AGENT DELIVERY DEVICE - A therapeutic agent delivery device and method for eluting a therapeutic agent to a target location are disclosed. The device may comprise a first conductive element, a second conductive element, an electrochemical composition including an electrolyte and a therapeutic agent, and a permeable membrane covering the electrochemical composition. The first conductive element and the second conductive element are adapted to be connected to a voltage source. When the voltage source is connected to the first conductive element and the second conductive element, an electrochemical reaction occurs causing the therapeutic agent to pass through the permeable membrane and thereby to elute to a target location. | 12-16-2010 |
20100331761 | Apparatus and Method for Dermatological Wound Healing - A method is provided for treating a dermatological wound. A first step of the method includes providing an iontophoretic apparatus. The iontophoretic apparatus includes at least one surface for contacting a surface of the dermatological wound, a current source electrically coupled to the apparatus, a suction mechanism operably coupled to the apparatus, and a source of therapeutic molecules. A second step of the method includes placing the at least one surface of the iontophoretic apparatus into contact with at least a portion of the dermatological wound surface. A third step of the method includes activating the current source so that a plurality of therapeutic molecules is delivered to the dermatological wound. A fourth step of the method includes activating the suction mechanism to remove fluid and/or debris from the dermatological wound. The second, third, and fourth steps of the method are repeated until the dermatological wound is sufficiently healed. | 12-30-2010 |
20100331762 | Refillable Reservoir Lead Systems - Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body. | 12-30-2010 |
20110009806 | MEDICAL DEVICE HAVING ONE OR MORE ACTIVE STRANDS - The present embodiments provide an elongate medical device comprising a plurality of strands twisted in a generally helical manner to form a tubular shape having a longitudinal axis. A first strand of the plurality of strands is moveable with respect to at least a second strand of the plurality of strands. Actuation of the one or more strands may perform a medical function or actuate an associated distal component. A working lumen of the tubular member may remain unobstructed for delivery of medical components or fluids. | 01-13-2011 |
20110009807 | VARIABLE CURRENT DENSITY SINGLE NEEDLE ELECTROPORATION SYSTEM AND METHOD - This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue. | 01-13-2011 |
20110046540 | Apparatus for Trans-Cerebral Electrophoresis and Methods of Use Thereof - The present invention provides apparatus and methods for the delivery of therapeutic agents to target tissues by electromigration. The utilization of electric fields according to the methods of the invention aids in the distribution and targeting of therapeutic agents, in particular, where standard means of agent application in the target tissue is insufficient to achieve prophylactic or therapeutic results. In particular embodiments, the present invention utilizes a convective force in combination with the developed electric fields to further increase the flux of the therapeutic agent or to further improve distribution of the therapeutic agent within the target tissues. | 02-24-2011 |
20110087155 | TRANSMUCOSAL DRUG DELIVERY DEVICE AND METHOD INCLUDING ELECTRICALLY-ACTUATED PERMEATION ENHANCEMENT - Intralumenal devices and methods are provided for transmucosal drug delivery. The device may comprise a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion. | 04-14-2011 |
20110092883 | TRANSDERMAL DRUG ADMINISTRATION APPARATUS AND TRANSDERMAL DRUG ADMINISTRATION UNIT - According to one embodiment, a transdermal drug administration apparatus includes a first member having a protrusion on a facing surface opposed to a skin and a guide hole in the protrusion and a second member having a needle portion located in the guide hole and movable in a first direction across a surface of the skin. | 04-21-2011 |
20110092884 | Device for Skin Treatment - Disclosed herein is a device for skin treatment, which precisely transmits high-frequency energy to a target portion of skin tissue without causing a burn on the outer layer of the skin, thus artificially damaging the portion and inducing a wound curing reaction, therefore leading to the regeneration of skin and the propagation of collagen. The device prevents the surface of skin from suffering an injury during insertion, alleviates pain, and keeps the depth to which the needle is inserted into the skin uniform. The device includes a plurality of needles coated with an insulator except for sharp ends. A needle holding unit holds the needles. A drive unit directly or indirectly transmits a force to the needle holding unit, thus allowing the needles to be inserted into the skin. An electromagnetic wave transmitting unit is electrically connected to the needles and transmits electromagnetic waves to the needles. | 04-21-2011 |
20110118656 | Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject - A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more sheaths configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more applicators supported by the one or more sheaths and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject. | 05-19-2011 |
20110125081 | Drug delivery apparatus guided by Micro Electrical Field Network for target cell of liver - A drug delivery apparatus guided by micro electrical field network for target cells of liver comprises a low-voltage micro- electrical field generator and a drug delivery catheter which gets into a liver through an endoscope or indwelling catheter along blood vessels, wherein at least two drug infusion holes and a first array of electrodes are provided at the front end of the drug delivery catheter; a second array of electrodes is set on the exterior of the liver; the first array of electrodes and the second array of electrodes are connected with the pulse output terminal of the low-voltage micro-electrical field generator; the drug delivery catheter is connected through with a drug transportation device. | 05-26-2011 |
20110130708 | Directional Delivery of Energy and Bioactives - Systems and methods are disclosed for the treatment of a target tissue by directionally delivering energy and/or bioactive materials to achieve a therapeutic effect. A balloon catheter system having a balloon portion and a plurality of electrodes may be energized to selectively deliver energy, bioactive materials, or a combination thereof to target tissue including tissues disposed about a lumen. The tissue may be targeted by applying energy, making tissue impedance analysis, and further selectively energizing electrodes through the use of an energy source with a controller. | 06-02-2011 |
20110130709 | SYSTEMS AND METHODS FOR ELECTRIC FIELD ASSISTED DELIVERY OF THERAPEUTIC AGENTS - Methods of iontophoretically delivering therapeutic agents to diseased tissue, such as for tumor therapy, are disclosed. In one embodiment, the distal end of an endoscopic device is transorally introducing into the gastro-intestinal tract. A delivery element is advanced from the endoscopic device through a wall of the gastro-intestinal tract and into an adjacent pancreas. A therapeutic agent is delivered from the delivery element into the pancreas, an electric field is generated to drive the emitted therapeutic agent into surrounding tissue of the pancreas, causing the emitted agent to penetrate the surrounding tissue. | 06-02-2011 |
20110144566 | Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject. | 06-16-2011 |
20110152748 | Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject - A method for enhancing an immune response in a vertebrate subject is described. The method includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject. | 06-23-2011 |
20110152749 | EYE INJECTION DEVICE - An injection device for injecting a product into an eye, said device comprising an injection needle and a support on which the injection needle is fixed, said device being characterized in that it comprises a locating mark disposed in such a way that the latter can be placed in contact with a defined bearing region of the surface of the eye, before any contact of the injection needle with said surface, and can then be kept in contact with said bearing region during a stage of penetration of said injection needle through said surface of the eye. | 06-23-2011 |
20110152750 | Systems devices, and methods including catheters configured to monitor and inhibit biofilm formation - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject. | 06-23-2011 |
20110152751 | Systems, devices, and methods including catheters having UV-Energy emitting coatings - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject. | 06-23-2011 |
20110152752 | Systems, devices, and methods including catheters having components that are actively controllable between transmissive and reflective states - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject. | 06-23-2011 |
20110160642 | PEGYLATED LIPOSOMAL FORMULATIONS FOR PHOTODYNAMIC TREATMENT OF INFLAMMATORY DISEASES - A PDT treatment system designed to treat all types of human inflammatory disorders. A suitable drug delivery system is developed to target proliferating cells, at inflamed sites, populated with macrophages and other inflammatory mediators. The hydrophobic photosensitizer is loaded into the liposomal bilayer formed of synthetic phospholipids; at least one of the synthetic phospholipids is conjugated to polyethylene glycol (PEG) molecules, to prevent accumulation in the liver and spleen. Further, (PEG) formulated photosensitizer increases the circulatory half-life of the drug, enhances solubility, and modifies pharmacokinetic and pharmacodynamic properties. The formulation, thus, leads to a higher amount of delivered drug to the diseased target synovial tissue, increasing clinical effectiveness. In one embodiment, pegylated liposomes loaded with mTHPC are administered to diseased synovial joints, followed by light irradiation. Activated photosensitizer induces cytotoxic effect in the diseased synovial cells, thus preventing further inflammation and joint erosion and minimizing joint damage. | 06-30-2011 |
20110160643 | Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject. | 06-30-2011 |
20110160644 | Systems, devices, and methods including catheters configured to release ultraviolet energy absorbing agents - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject. | 06-30-2011 |
20110190689 | INTRAVAGINAL THERAPY DEVICE - An intravaginal treatment device (ITD) provides therapeutic light and fluid treatments. Vision systems throughout supporting networks and devices allow for directed control of the treatment processes. The ITD uses illumination to gather various types of imager data that is used to identify and conditions, monitor the treatment process, and evaluate treatment efficacy. Specific frequency light emissions and associated fluids are used to reduce overabundant flora, at least assist in elimination of fungal, viral and bacterial invaders, and enhance the detection process. Several configurations and sizes of ITDs with light and fluid therapy, also have a built in optics assembly (camera, light sources, etc.) for capturing intravaginal still images and video of vaginal channels, cervix, cervical channels, uterus and fallopian tubes. Some ITD configurations are also wearable and include full fluid delivery infrastructure unlike some other ITDs with external components. Supporting devices include local and remotely located computing devices such as laptops, smart phones, and independent monitors. ITDs can be fully or partially inserted via the vaginal channel, and operate in a stand-alone mode or pursuant to remote control. Therapy procedures may be preset or programmed to deliver continuous, periodic and scheduled performance with various underlying parameters defined in the preset or programming processes. | 08-04-2011 |
20110208112 | MEDICAL DEVICE FOR INJECTING LOCAL ANESTHETIC - A medical device for injecting a liquid medicine into an organism. The device comprises a needle, an injection tube attached to the posterior end of the needle and a housing having a conduit at the distal end. The needle being placed inside the housing in such a way that the needle can move from a position where entire length of needle is situated within the housing and the conduit to a position where the needle is protruded out of the housing. The device allows an anesthesia provider to perform a nerve block more safely and efficiently. In one embodiment of the device, an injection pad is used to single handedly inject syringes of liquid medicine into the injection tube. | 08-25-2011 |
20110238002 | DEVICE FOR PHOTO-DYNAMIC THERAPY OF A LIVING ORGANISM'S TISSUES - Devices for photo-dynamic therapy of a living organism's tissues comprising an optical light exposure system (I) containing at least one source of light ( | 09-29-2011 |
20110251545 | Cell Reservoirs Created by Polymer Plugs - Described herein generally are catheter systems used to deliver cells and other bioactive materials to a target location within the vascular system of the human body, and methods of delivering cells and other bioactive materials to such target locations. | 10-13-2011 |
20110264029 | IONTOPHORETIC DELIVERY SYSTEM - Methods, systems and other embodiments associated with administering ionotophoretic medicines are presented. A method of administering ionotophoretic medicines includes applying a voltage across a body tissue and an iontophoretic solution including medicine. At least some of the iontophoretic solution including medicine is then injected into the body tissue without requiring the iontophoretic transportation of the iontophoretic solution including medicine through the skin. The iontophoretic solution is typically injected while the voltage is applied. The voltage causes an ionic current of iontophoretic medicine to flow which disperses the medicine within the body tissue toward body tissue connected to the voltage. | 10-27-2011 |
20110264030 | DELIVERY APPARATUS AND ASSOCIATED METHOD - A delivery apparatus for delivering a cargo to a target site of internal body tissue is provided. The delivery apparatus comprises a flexible tubular member having a distal end adapted for insertion proximate to the target site. A first electrode is configured for insertion within the flexible tubular member such that the first electrode is capable of being disposed proximate to the target site. A second electrode is configured to cooperate with the first electrode to form an electric field. A delivery component has a cargo carried thereby and is coupled with the first electrode. The delivery component is configured to degrade when exposed to the electric field such that the cargo is released to the target site upon degradation thereof. An associated method is also provided. | 10-27-2011 |
20110288468 | DRUG-DELIVERY ACCESSORY FOR AN IMPLANTABLE MEDICAL DEVICE - An implantable drug-delivery sleeve for an elongate component of an implantable medical device. The sleeve includes a tubular substrate having a lumen configured to receive the elongate component so as to allow relative displacement of the substrate and the elongate component, wherein the substrate is shaped so as to be retained stationary at a desired position along the elongate component, and a drug releasably carried by the substrate. | 11-24-2011 |
20110288469 | SURGICAL DEVICE AND METHOD FOR PERFORMING COMBINATION REVASCULARIZATION AND THERAPEUTIC SUBSTANCE DELIVERY TO TISSUE - A surgical device is provided for both ablating a channel in a patient's tissue and also delivering a therapeutic agent. The device includes an elongated multi-lumen tube, an elongated tissue ablating assembly, and a therapeutic agent delivery assembly. The therapeutic agent is capable of being delivered into the channel and/or to the surrounding tissue. The device may further include a second multi-lumen tube also capable of delivering therapeutic agents. A method is also provided for using such a surgical device to ablate a channel in a patient's tissue and also deliver a therapeutic agent to the tissue, for example, for transmyocardial revascularization or other procedures. | 11-24-2011 |
20110319809 | CATHETER DEVICE FOR DELIVERY ENERGY TO A VEIN - The present disclosure relates to devices, systems, and methods associated with a catheter device for delivering energy to a vein. One or more catheter devices include a cooling device, an infusion device, and an energy delivery device for delivering energy to a vein to treat incompetent valves. | 12-29-2011 |
20120016291 | ROBOTICALLY CONTROLLED INTRAVASCULAR TISSUE INJECTION SYSTEM - A robotic catheter system includes a controller including a master input device and instrument driver in communication with the controller. An elongate flexible guide instrument is operatively coupled to the instrument driver. A fluid injection needle may be advanced from, or retracted into, a distal portion of the guide instrument. | 01-19-2012 |
20120035530 | DRUG RELEASING COATINGS FOR MEDICAL DEVICES - The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups. | 02-09-2012 |
20120059308 | PERIPHERAL NERVE BLOCK CATHETER - An anesthetic nerve block catheter and methods of using the anesthetic nerve block catheter to perform a nerve block or continuous nerve block procedure are disclosed. | 03-08-2012 |
20120078161 | Apparatus for electrically mediated delivery of therapeutic agents - Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state. | 03-29-2012 |
20120078162 | METHOD AND DEVICE FOR ELECTROMOTIVE DELIVERY OF MACROMOLECULES INTO TISSUE - Electromotive delivery of macromolecules can be provided using a delivery device including a first chamber for contacting a macromolecule delivery medium to a surface of a tissue or other anatomy of a patient; and a second chamber for contacting a receiving medium to the patient. A first electrode can be disposed in the first chamber so as to not directly contact the macromolecule delivery medium. A second medium having a buffering agent can be used to keep the first electrode from coming into direct contact with the macromolecule delivery medium. A second electrode can be disposed within the receiving medium in the second chamber such that the second electrode does not directly contact the patient. An electric field can be generated using the first and second electrodes in order to cause the macromolecule delivery medium to move into the tissue of interest from the first chamber of the delivery device. | 03-29-2012 |
20120078163 | METHOD OF GENERATING CONNECTIVE TISSUE - A method of generating bone or connective tissue in a subject in need thereof, the method comprising: (a) implanting a scaffold in a damaged region of the subject, the scaffold comprising a tissue growth promoting agent; and (b) enhancing uptake of the tissue growth promoting agent into cells located on the scaffold, wherein the enhancing is effected by induced poration of the cells thereby generating bone or connective tissue in the subject. Kits for generating bone or connective tissue are also provided. | 03-29-2012 |
20120089078 | METHODS AND SYSTEMS FOR TOXIN DELIVERY TO THE NASAL CAVITY - Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity. | 04-12-2012 |
20120143120 | METHOD AND DEVICE FOR TREATING MICROSCOPIC TUMORS REMAINING IN TISSUES FOLLOWING SURGICAL RESECTION - This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement. | 06-07-2012 |
20120238943 | METHODS OF ELECTRIC FIELD INDUCED DELIVERY OF COMPOUNDS, COMPOSITIONS USED IN DELIVERY, AND SYSTEMS OF DELIVERY - In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of delivering a compound, a composition, and the like. | 09-20-2012 |
20120238944 | Device for Actively Removing a Target Cell from Blood or Lymph of a Vertebrate Subject - Devices, systems, and methods are described herein for controlling the level of one or more target cell types in the blood fluid and/or lymph fluid of a vertebrate subject. Devices, systems, and methods are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to the at least one lumen; one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; at least one reactive component disposed in the at least one treatment region; and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen. | 09-20-2012 |
20120238945 | Device for Actively Removing a Target Cell from Blood or Lymph of a Vertebrate Subject - Devices, systems, and methods are described herein for controlling the level of one or more target cell types in the blood fluid and/or lymph fluid of a vertebrate subject. Devices, systems, and methods are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to the at least one lumen; one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; at least one reactive component disposed in the at least one treatment region; and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen. | 09-20-2012 |
20120259268 | PHOTODYNAMIC THERAPY FOR TUMORS WITH LOCALIZED DELIVERY - Methods and systems for treatment of hypoxic tumors are provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering an oxygenating agent to the tumor tissue via the delivery device and radiating the tumor tissue with radiation. Methods and systems of treatment of tumors are also provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering a photosensitizing agent to the tumor tissue via the delivery device, and radiating the tumor tissue with light. | 10-11-2012 |
20120259269 | IONTOPHORESIS DRUG DELIVERY SYSTEM AND METHOD FOR DENERVATION OF THE RENAL SYMPATHETIC NERVE AND IONTOPHORETIC DRUG DELIVERY - A system for denervation of the renal sympathetic nerve and iontophoresis drug delivery includes an iontophoresis catheter fitted with a drug coated balloon. The balloon contacts the vessel wall when inflated. One or more electrodes are associated with a surface of the balloon, and may be disposed on an outer surface of the balloon. The electrodes are operably coupled to an energy source configured to produce a bipolar or monopolar electric field between two balloon electrodes and/or between one balloon electrode and another electrode placed in contact with the patient's body. The drug-delivery catheter produces an electric potential gradient within adjacent tissue, that, facilitates iontophoresis delivery of a drug. The catheter can also include a store of one or more drugs to be delivered to the targeted tissue. | 10-11-2012 |
20120277661 | METHOD AND APPARATUS FOR DELIVERY OF THERAPEUTIC AGENTS - Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention comprises means for the controlled administration of the therapeutic agent through an orifice to the patient, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and means for generating an electrical signal operatively connected to the electrodes. | 11-01-2012 |
20120289888 | Irreversible Electroporation and Tissue Regeneration - A method and device are herein described to treat a target region of tissue, using at least one energy delivery device coupled to a power source and positioned in a treatment position so as to irreversibly electroporate tissue to ablate a target region, and introduce regenerative materials into a treated region. | 11-15-2012 |
20120316488 | Method and Devices for Treating Atrial Fibrillation by Mass Ablation - Apparatus and method for ablating target tissue including a non-linear area of tissue in the left atrium of a patient. The method can include selecting an ablation apparatus having an ablator with a tissue engagement section, penetrating a chest cavity of the patient, and identifying the target tissue. The method can also include positioning the ablation apparatus adjacent to the target tissue so that the tissue engagement section can transfer ablation energy to the target tissue. The method can further include energizing the tissue engagement section with ablation energy in order to create a footprint on the non-linear area of tissue in the left atrium and to reduce an overall mass of excitable tissue in the left atrium. | 12-13-2012 |
20120316489 | METHOD AND SYSTEM FOR TREATING CANCER - A method and system for treating cancer of a patient are disclosed. In a first aspect, the method comprises injecting bleomycin into the patient and administering excorporeal ultrasound to a localized area of the cancer, wherein the bleomycin more readily enters the localized area to treat the cancer of the patient. In a second aspect, the system comprises an injection unit for injecting bleomycin into the patient and an ultrasound module for administering excorporeal ultrasound to a localized area of the cancer, wherein the bleomycin more readily enters the localized area to treat the cancer of the patient. | 12-13-2012 |
20130012865 | CODON-OPTIMZED HEPATITIS B VIRUS CORE ANTIGEN (HBCAG) - A needle device for the delivery of therapeutic material into tissue comprising a connection to a pressure generation element, a lumen adapted for the passage of a therapeutic material, and a needle barrel, wherein each needle barrel comprises an opening adapted to control and deliver a pressure transmitted from the pressure generation element into a tissue to cause an increase in the permeability of a cell membrane to the therapeutic material. | 01-10-2013 |
20130012866 | APPARATUSES FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS - Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation. | 01-10-2013 |
20130012867 | METHODS AND APPARATUS FOR PERFORMING A NON-CONTINUOUS CIRCUMFERENTIAL TREATMENT OF A BODY LUMEN - Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided. | 01-10-2013 |
20130041310 | Oral Mucosal Electroporation Device and Use Thereof - The present invention relates to electroporation (EP) devices that are able to generate an electroporation causing electrical field at the mucosal layer, and preferably in a tolerable manner. Further, it includes the generation of a protective immune response, cellular and/or humoral, using the oral EP device along with a genetic construct that encodes an immunogenic sequence. | 02-14-2013 |
20130053758 | Triple Balloon Occlusion and Infusion Catheter - Disclosed are balloon catheters for forming liquid cast biodegradable arterial stents, typically, the balloon catheters include multiple balloons and multiple ports and include an element for promoting or initiating curing of a polymer solution via polymerization or cross-linking. | 02-28-2013 |
20130060188 | PHOTOCATALYTIC DISINFECTION OF IMPLANTED CATHETERS - An implantable catheter is provided that may be disinfected without removal from the body of a patient, using a photocatalytic method to activate a reaction on the catheter surface that generates oxidizing agents in the form of Reactive Oxygen Species (“ROS”) and thus destroy microorganisms in a biofilm that is present or forming. A catheter system includes the implantable catheter, a light source, and a source of power operably connected to the light source. Methods are also provided for disinfecting the implantable catheter in vivo. | 03-07-2013 |
20130072852 | SYSTEMS AND METHODS FOR TREATING PATHOGENIC INFECTION - An internal anatomic target that is infected by pathogenic microorganisms is treated using an applicator configured for delivering a therapeutic solution thereto and an UV light-emitting device transmits UV light thereon. | 03-21-2013 |
20130102954 | CURRENT APPLICABLE MULTI-NEEDLE SYRINGE, AND AUTOMATIC INJECTION DEVICE - Disclosed is an electrical signal applicable multi-needle syringe. The present invention comprises: a hollow cylinder; a needle hub closely coupled to the rear end of the cylinder; a plurality of needles placed at regular intervals inside the cylinder in such a way that the front ends are further protruded compared with the front end of the cylinder and the drug which is injected through the needle hub is sucked through the rear ends; a first electrode stored inside the cylinder, and commonly connected to a part of the plurality of needles; and a second electrode stored inside the cylinder, and commonly connected with the rest of the plurality of needles. Therefore, it is possible to inject a drug and to simultaneously apply a high frequency directly into the skin through a multi-needle injected into the skin by applying a high frequency between the first electrode and the second electrode, thereby promoting the activation of the injected drug. | 04-25-2013 |
20130110031 | BIOCOMPATIBLE DRUG DELIVERY APPARATUS AND METHODS | 05-02-2013 |
20130178788 | ELECTROOSMOTIC CONVECTION-ENHANCED DELIVERY SYSTEM - Apparatuses and methods for electrokinetic transport of fluids to patients. Drug-containing solutions may be placed in vial-like reservoir, which is connected to an apparatus such as a traditional catheter or other device capable of holding a drug-containing solution. Instead of a vial-like reservoir, a doped infusion pad or a gel may be used as a source of the drug-containing solution. The reservoir and apparatus may thus be the same component. The methods and apparatuses disclosed herein may also be used to transport fluid alone to achieve a clinical effect. The apparatus is placed at the point of drug delivery. The counter-electrode may be placed in or on a patient. Current is passed from the reservoir to the counter-electrode. Through electrokinetic transport, drug-containing solution is delivered along a current path from the drug source to the counter-electrode. A hollow fiber catheter for use in electrokinetic transport is also disclosed. | 07-11-2013 |
20130197426 | SYSTEMS AND METHODS FOR ANESTHETIZING EAR TISSUE - A system and method for use in iontophoretic anesthesia of a tympanic membrane are disclosed. The system generally includes an earplug and an electrode device. The earplug includes at least one sealing member for sealing the earplug in an ear canal. The method involves using the system on a human or animal subject. | 08-01-2013 |
20130261533 | SINGLE OPERATOR ANESTHESIA AND DRUG DELIVERY SYSTEM - The single operator anesthesia and/or drug delivery system disclosed herein incorporates a variable-output nerve stimulator and an aspirating syringe pump, both of which are controlled via a needle with controls for stimulation and aspiration/injection on the needle itself. Pre-set injection pressures can be monitored and regulated via the syringe pump. Further pressures can be objectively limited by the syringe pump. With this system, the single operator can with sterile conditions, incorporate ultrasound, nerve stimulation, and landmark palpation while simultaneously performing the block without any help from another caregiver/operator. This system can easily store or translate to the electronic medical record the specifics of the block, including for example pressures and stimulation level). The present invention further provides a means to remove all direct human elements of a nerve block and perform a nerve injection robotically or from a remote location. | 10-03-2013 |
20130267888 | METHODS AND APPARATUS TO INACTIVATE INFECTIOUS AGENTS ON A CATHETER RESIDING IN A BODY CAVITY - Methods and apparatus for the inactivation of infectious agents in, on or around a catheter residing in a patient's body cavity. The method comprises transmitting non-ultraviolet sterilizing electromagnetic radiation (EMR) substantially axially along an optical element in the catheter body. Through delivery of the sterilizing EMR to particular areas of highest infection, the present disclosure is able to inactivate the major sources of infection in catheters. | 10-10-2013 |
20130281915 | VACUUM ENABLED DEVICE WITH MICRO-NEEDLE INSERT FOR ACNE TREATMENT - Methods and an apparatus for extracting an underlying sebum of a pilosebaceous unit for the treatment of acne or closed comedones is disclosed. The method includes placing a vacuum suction pressure device on a surface of a skin area to be treated for an acne condition, applying the vacuum suction pressure on the surface of the skin area to pull the skin area into an aperture opening of the vacuum suction pressure device and to extract an underlying sebum of the pilosebaceous unit, puncturing the surface of the skin area containing at least one pilosebaceous unit with at least one micro-needle insert unit recessed into the aperture opening of the vacuum suction pressure device to create a lesion on the pilosebaceous unit and applying a subsequent dose of vacuum suction pressure or an application of broad band light to the skin area to be treated. | 10-24-2013 |
20130296767 | Methods and Apparatus for Performing a Non-Continuous Circumferential Treatment of a Body Lumen - Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided. | 11-07-2013 |
20130303972 | METHODS AND APPARATUS FOR REDUCING COUNT OF INFECTIOUS AGENTS IN INTRAVENOUS ACCESS SYSTEM - The device disclosed herein may be affixed over a transparent dressing overlying the catheter entry point, or may be used independent of such a dressing. The device may be affixed to the catheter insertion site using an adhesive or fastening band, or through other methods. Depending on context, the device may be used continuously or periodically, and may be affixed such that it is directly abutting a transparent dressing or directly adjacent to the skin surface, or it may be spaced a certain distance from the skin. If spaced from the skin, light may be directed from the light sources, either directly or indirectly through optical conduits. Preferably the light sources will be positioned such that light from the light sources overlaps at one or more areas on the skin, especially the catheter entry point. | 11-14-2013 |
20130324910 | ABLATION DEVICE WITH DRUG DELIVERY COMPONENT AND BIOPSY TISSUE-SAMPLING COMPONENT - An ablation device includes a handle assembly, an ablation electrode extending from the handle assembly, and one or more delivery needles extending from the handle assembly. The ablation electrode includes an ablation needle. The ablation needle includes a distal end portion including a drug delivery port defined therethrough. The ablation device also includes and a biopsy tool extending from the handle assembly. | 12-05-2013 |
20130324911 | ABLATION DEVICE WITH DRUG DELIVERY COMPONENT - An ablation system includes a source of electrosurgical energy, a source of coolant fluid, and an ablation electrode assembly operatively connected to the source of electrosurgical energy and fluidly-coupled to the source of coolant fluid. The ablation electrode assembly includes a hub defining a chamber therein and one or more electrically-conductive ablation needles extending from the hub. The ablation system also includes one or more delivery needles extending from the hub. The one or more delivery needles are selectively moveable from a first position, wherein the distal end of the delivery needle is disposed proximal to the distal end portion of the ablation needle, to at least a second position, wherein at least the distal end of the delivery needle is disposed distally beyond the distal end portion of the ablation needle. | 12-05-2013 |
20140005591 | Devices and Methods for Photodynamically Modulating Neural Function in a Human | 01-02-2014 |
20140005592 | COSMETIC DEVICE USING HIGH-FREQUENCY WAVES | 01-02-2014 |
20140012182 | ALZHEIMER'S DISEASE TREATMENT WITH MULTIPLE THERAPEUTIC AGENTS DELIVERED TO THE OLFACTORY REGION THROUGH A SPECIAL DELIVERY CATHETER AND IONTOPHORESIS - This invention describes the administration of multiple therapeutic agents with insulin in conjunction with bexarotene, ketamine, monoclonal antibodies Etanercept, IGF-1, and acetylcholine esterase inhibitors physostigmine, for treatment of Alzheimer's disease and other neurodegenerative diseases. Insulin, improves memory; also augments and amplifies the effects of the adjuvant therapeutic agents (paracrine and intracrine effects) and consequently reduces the β amyloid, its soluble precursors, prevents damage to the neuronal skeletal network (taupathy), and blocks glutamate excitotoxicity, reduces brain inflammation, prevents apoptosis, and increases the acetylcholine levels in the neurons and synapses; by using a combination of insulin, bexarotene, ketamine, Etanercept, IGF-1, and physostigmine therapeutic agents. The results are achieved by using the specially designed Iontophoresis incorporated olfactory mucosal delivery (ORE) catheter device located at the olfactory nerves, sphenoid sinus, and adjacent structures described here, to transport the large molecules of therapeutic agents to treat AD delivered to the CNS bypassing BBB from ORE. | 01-09-2014 |
20140018723 | Apparatuses for Renal Neuromodulation and Associated Systems and Methods - Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation. | 01-16-2014 |
20140039380 | DIRECT ACCESS ATHERECTOMY DEVICES AND METHODS OF USE - An atherectomy device and method has cannula systems having lumens adapted for insertion of a blood filter and an atherectomy catheter useful for performing atherectomy directly on a patient's cardiovascular tissue. Other embodiments include a lumen for arterial perfusion useful in providing oxygenated blood to the aorta during cardiopulmonary bypass. The distal end of the atherectomy catheter includes an assembly that has a pincer, a loop with or without a mesh, laser, hydraulics, or other suitable mechanism adapted for removing atheroma from a cardiac or vascular tissue. Methods of using the systems for vascular atherectomy are also disclosed herein. | 02-06-2014 |
20140121587 | INJECTION NEEDLE AND DEVICE - Several needle assemblies and intracellular delivery devices that are used for the delivery of prophylactic and/or therapeutic material (i.e., delivered agents) into a tissue of a subject are disclosed. Preferably, the needle assemblies and/or the intracellular delivery devices comprise needles and/or needle electrodes, which are disposed in an array (e.g., a Y-type array having three outer needles and a center needle), wherein each needle in the array has a closed end and a plurality of apertures along each needle barrel, and the apertures on the needle barrels of the outer needles of the array are positioned to deliver the delivered agent toward the apertures of the center needle and/or an adjacent needle, but not outside of the active zone defined by the area within the needle array and the apertures on the needle barrel of the center needle are positioned to deliver the delivered agent toward the outer needles. | 05-01-2014 |
20140142492 | ELECTRO-MICRONEEDLE INTEGRATED BODY FOR IN-SITU CUTANEOUS GENE TRANSFER AND METHOD OF MANUFACTURING SAME - Provided is an electro-microneedle integrated body in which a dissolving microneedle and an electrode for electroporation are integrated into one, which enables a focused and efficient intracutaneous gene release for percutaneous gene delivery and intracellular gene delivery occurring in one in-situ treatment site The electro-microneedle integrated body according to the present invention includes an electrode for electroporation which is contacted with skin of a human body to apply an electric field pulse, including a base part and a plurality of electrode parts protruding from the base part, and a microneedle adhered to each electrode part and inserted into the skin of a human body, including a biocompatible and biodegradable viscous material and a genetic material, wherein the microneedle degrades within the skin, and the electric field pulse is applied through the electrode for electroporation in a site in which the microneedle is inserted. | 05-22-2014 |
20140148753 | SYSTEMS AND METHODS FOR MAKING AND USING AN ELECTRICAL STIMULATION SYSTEM WITH PHOTONIC STIMULATION CAPABILITIES - An electrical stimulation lead includes electrodes disposed along a distal end portion of a lead body; terminals disposed along a proximal end portion of the lead body; and stimulation conductors electrically coupling the terminals to the electrodes. A light-emitter is disposed along the distal end portion of the lead body. A light source is disposed along the at least one lead body and converts received electrical power into light. An optical transport medium is disposed along the at least one lead body. The optical transport medium extends between the light source and the light-emitter. A light source conductor electrically couples the light source and the terminals. A drug-dispensing port is defined along the distal end portion of the lead body. A drug-delivery channel is in fluid communication with the at least one drug-dispensing port and extends to the proximal end portion of the lead body. | 05-29-2014 |
20140163453 | Photodynamic Bone Stabilization and Drug Delivery Systems - Photodynamic bone stabilization and drug delivery systems are disclosed herein. In an embodiment, a photodynamic bone stabilization and drug delivery system of the present disclosure includes an insertion catheter having an inner void for passing at least one light-sensitive liquid, and an inner lumen; an expandable portion releasably engaging a distal end of the insertion catheter, wherein the expandable portion comprises an inner expandable portion in communication with the inner lumen of the insertion catheter and sufficiently designed to maintain a light-sensitive liquid therein; and an outer expandable portion, surrounding the inner expandable portion, sufficiently designed to house and release at least one additive from the outer expandable portion in an outward direction from the inner expandable portion; and a light-conducting fiber sized to pass through the inner lumen of the insertion catheter and into the inner expandable portion for delivering light energy to the light-sensitive liquid. | 06-12-2014 |
20140180196 | TUNED RF ENERGY AND ELECTRICAL TISSUE CHARACTERIZATION FOR SELECTIVE TREATMENT OF TARGET TISSUES - A catheter and catheter system can use energy tailored for remodeling and/or removal of target material along a body lumen, often of atherosclerotic material of a blood vessel of a patient. An elongate flexible catheter body with a radially expandable structure may have a plurality of electrodes or other electrosurgical energy delivery surfaces to radially engage atherosclerotic material when the structure expands. An atherosclerotic material detector system may measure and/or characterize the atherosclerotic material and its location, optionally using impedance monitoring. | 06-26-2014 |
20140188035 | METHODS AND DEVICES FOR IN VIVO TARGETED LIGHT THERAPY - Catheter-based systems for in-vivo targeted light therapy include a first type of catheter configured for photo-activating photosensitive substances in tissue, and a second type of catheter configured for photo-degrading photosensitive substances in tissue. The catheters may be configured to produce light using a variety of light sources, such as light emitting diodes (LEDs) and fiber optics. The light transmission is directed to tissue in such a way that only portions of tissue in a treatment area are exposed to light, depending upon whether the tissue is diseased or healthy. | 07-03-2014 |
20140200503 | SYSTEMS, DEVICES, AND METHODS FOR ISOLATION OF STEM CELLS - The present disclosure relates, in some embodiments, to apparatus, systems, methods, and compositions for purifying cells (e.g., adipocytes, stem cells) from mammalian tissues (e.g., adipose tissues). For example, the present disclosure relates to apparatus, systems, methods, and compositions for purifying and/or preserving adipocytes and/or stem cells from fat tissue of a mammalian subject according to some embodiments. | 07-17-2014 |
20140200504 | APPARATUS AND METHOD FOR DELIVERING INTRALUMINAL THERAPY - A catheter and methods for luminal therapy are provided wherein a catheter has an outer balloon with a multiplicity of apertures for infusing one or more therapeutic agents into a vessel wall, an intermediate balloon having a multiplicity of apertures offset from the apertures of outer balloon to serve as a baffle that reduces jetting and promotes uniform distribution of therapeutic agent exiting through the outer balloon, and an impermeable inner balloon disposed within the intermediate balloon that enables the intermediate and outer balloons to be forced into engagement with the vessel wall to dilate the vessel and disrupt plaque lining the vessel wall and to also facilitate the uniform delivery of the therapeutic agent. The outer balloon may include protrusions that contact the vessel wall to disrupt the plaque, bumpers to reduce washout during infusion of therapeutic agents; the intermediate balloon may include a texture, ribs or protrusions on its outer surface to prevent adhesion to the outer balloon during dilation of the vessel; and the catheter may include a guide wire lumen sized to accept an energy delivery device to delivery energy that enhances uptake of the therapeutic agent or prolongs therapeutic effectiveness of the agent. | 07-17-2014 |
20140207050 | USE OF LOCAL ANESTHESIA AND ELECTRICAL STIMULATION IN PERIPHERAL WOUND TREATMENT - A wound therapy method that results in improved wound healing for conditions including diabetic foot ulcers, pressure ulcers, and arterial and venous ulcers is described. The wound therapy method uses local anesthetic injections in an area surrounding the wound combined with electrical stimulation causing local and deep muscle contraction in the same area. The method leads to increased vasodilation, increased tissue oxygen levels at the target site, and increased blood flow to the target site. This causes local angiogenesis and tissue perfusion that increases wound healing rates and decreases future wound occurrences. | 07-24-2014 |
20140213961 | TREATMENT OF MOOD AND/OR ANXIETY DISORDERS BY ELECTRICAL BRAIN STIMULATION AND/OR DRUG INFUSION - A system and method for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to treat mood and/or anxiety disorders uses an implantable system control unit (SCU), specifically an implantable signal/pulse generator (IPG) or microstimulator with one or more electrodes in the case of electrical stimulation, and an implantable pump with one or more catheters in the case of drug infusion. In cases requiring both electrical and drug stimulation, one or more SCUs are used. Alternatively and preferably, when needed, an SCU provides both electrical stimulation and one or more stimulating drugs. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. | 07-31-2014 |
20140221905 | Device and Methods for Enhanced Multi-Delivery of Biologically Active Substances Into an Organism and To Prevent Local Irritation - Transnasal delivery of medication directly to a patient's brain is achieved using an iontophoresis wire cooperable with a medication administration device. A controller regulates an electric charge to the iontophoresis wire. The iontophoresis wire is insertable into each nasal cavity. This wire is preferably encased in a tube, through which the medication will be transnasally delivered. A cleaning solution may also be delivered to the nasal cavity after treatment to reduce irritation from the iontophoresis. | 08-07-2014 |
20140257171 | EAR MEDICATION DISPENSER WITH SENSOR - A device for dispensing medication to the ear with a tympanic membrane sensor and medication dispenser which dispenses medication upon identification of the tympanic membrane by the sensor is provided. Also provided are methods for using the device to dispense medications to the ear. | 09-11-2014 |
20140276359 | APPARATUS AND METHOD FOR TISSUE REJUVENATION - A method and an apparatus of applying carboxytherapy to a subject is disclosed. The method comprises the steps of: contacting a target body surface of the subject with a treatment device comprising a plurality of hollow needles attached to a contact surface of a housing and a CO | 09-18-2014 |
20140276360 | ELECTROPHORECTIC DRUG COATED BALLOON AND CONDUCTIVE POLYMER COATING - Balloon catheter configured to deliver a therapeutic agent upon provision of electric potential to the balloon, the catheter comprising an electrode disposed proximate the outer surface of the expandable member, a coating disposed on at least a portion of the outer surface, the coating including a therapeutic agent; and a power source in electrical communication with the electrode is described. | 09-18-2014 |
20140276361 | SYSTEMS AND METHODS FOR TREATING GLAUCOMA - A glaucoma treatment system includes: a cannula body configured to be positioned in an area of Schlemm's canal; an illumination guide extending along the cannula body; at least one drug source coupled to the cannula body; a cross-linking agent source coupled to the cannula body; and an illumination source coupled to the illumination guide. The at least one drug source includes a drug that promotes outflow of aqueous humor through the trabecular meshwork and into Schlemm's canal. The cannula body delivers the drug from the at least one drug source to the area of Schlemm's canal, and in response to changes in the outflow of aqueous humor, delivers the cross-linking agent to the area of Schlemm's canal. The illumination guide delivers photo-activating light from the illumination source to the area of Schlemm's canal. The photo-activating light activates the cross-linking agent, thereby stabilizing changes in the area of Schlemm's canal. | 09-18-2014 |
20140276362 | APPARATUS AND METHOD FOR TISSUE REJUVENATION - A method for treating skin in a subject is disclosed. The method comprises the steps of administering a stem cell composition into a target body site in the subject by subcutaneous, intradermal or topical delivery, and contacting the target body site with a treatment device designed for introducing CO | 09-18-2014 |
20140309579 | BALLOON CATHETER METHOD FOR REDUCING RESTENOSIS VIA IRREVERSIBLE ELECTROPORATION - Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The invention provides a balloon catheter with a particular electrode configuration. Also provided is a method whereby vascular cells in the area of the artery subjected to the trauma are subjected to irreversible electroporation which is a non-thermal, non-pharmaceutical method of applying electrical pulses to the cells so that substantially all of the cells in the area are ablated while leaving the structure of the vessel in place and substantially unharmed due to the non-thermal nature of the procedure. | 10-16-2014 |
20140316326 | DEVICE FOR THE TREATMENT OF AN OCULAR DISEASE - The present invention relates to an injection device comprising: —a first support ( | 10-23-2014 |
20140316327 | CONTINUOUS ANESTHESIA NERVE CONDUCTION APPARATUS, SYSTEM AND METHOD THEREOF - The invention generally relates to a continuous anesthesia nerve conduction apparatus and method thereof, and more particularly to a method and system for use in administering a continuous flow or intermittent bolus of anesthetic agent to facilitate a continuous or prolonged nerve block. In one embodiment, the apparatus includes a sheath having a proximal end, a distal end and at least one lumen extending from the proximal end to the distal end. The sheath also includes an embedded conductive element for transmitting an electrical signal from a proximal portion of the sheath to a distal portion of the sheath. A cannula is arranged in the at least one lumen of the sheath and has a distal end protruding from a distal portion of the sheath. The cannula is electrically coupled to at least a portion of the embedded conductive element and is configured to provide nerve stimulation. | 10-23-2014 |
20140316328 | CONTINUOUS ANESTHESIA NERVE CONDUCTION APPARATUS, SYSTEM AND METHOD THEREOF - The invention generally relates to a continuous anesthesia nerve conduction apparatus and method thereof, and more particularly to a method and system for use in administering a continuous flow or intermittent bolus of anesthetic agent to facilitate a continuous or prolonged nerve block. In one embodiment, the apparatus includes a sheath having a proximal end, a distal end and at least one lumen extending from the proximal end to the distal end. The sheath also includes an embedded conductive element for transmitting an electrical signal from a proximal portion of the sheath to a distal portion of the sheath. A cannula is arranged in the at least one lumen of the sheath and has a distal end protruding from a distal portion of the sheath. The cannula is electrically coupled to at least a portion of the embedded conductive element and is configured to provide nerve stimulation. | 10-23-2014 |
20140323951 | DEVICES FOR DELIVERING SUBSTANCES THROUGH AN EXTRA-ANATOMIC OPENING CREATED IN AN AIRWAY - Devices and methods for delivering substances to lung tissue through an extra-anatomic passage created in an airway. | 10-30-2014 |
20140330196 | APPARATUS FOR STIMULATING HAIR GROWTH AND/OR PREVENTING HAIR LOSS - A device to stimulate a scalp comprising an array of stimulating elements adapted to pierce the skin of the scalp no deeper than a thickness of a dermis, wherein the stimulating elements are arranged along a circumference of at least one wheel and the wheel is adapted to roll over the scalp. | 11-06-2014 |
20140343481 | SKIN TREATMENT SYSTEMS AND METHODS USING NEEDLES - A device for treating the skin comprises a handpiece assembly having a distal end and a proximal end and a tip on the distal end of the handpiece assembly. The handpiece assembly includes a fluid delivery conduit, a waste conduit and/or an energy delivery conduit. Further, the tip is configured to contact the skin. The tip comprises a peripheral lip and a plurality of needles generally positioned within the peripheral lip. The tip also comprises at least one opening in fluid communication with a fluid delivery conduit, at least one opening in fluid communication with a waste conduit and/or an energy contact point in electrical communication with an energy contact point and energy conduit in the main body portion. The plurality of needles may be movable with respect to the peripheral lip through the use of a pneumatic or other force. | 11-20-2014 |
20140343482 | ENDOLUMINAL DRUG DELIVERY DEVICES AND METHODS - A device and method for delivering a drug from inside a body lumen to tissue surrounding the body lumen. An endoluminal drug delivery device includes a dual-lumen catheter for housing a guidewire and a needle connectable to a drug source. The guidewire exits the catheter through an opening at the distal end, and the needle exits the catheter through an exit port in the outer wall of the catheter. A distal portion of the catheter has a single lumen and includes a taper, allowing the distal tip to act as a dilator. The device optionally includes a catheter lumen splitter and/or a handpiece assembly. A method of delivering fluid to tissue surrounding a body lumen includes inserting a guidewire into the body lumen, tracking the device over the guidewire, deploying the needle through the exit port to the tissue, delivering fluid, and retracting the needle into the catheter. | 11-20-2014 |
20140350455 | Intraluminal Activation System And Method Of Activating An Inactive Agent - An intraluminal activation system for activating an inactive agent includes a catheter defining an inflation lumen and a medical device lumen. A longitudinal distal segment of the catheter defines a transparent treatment region. An inflation balloon is disposed at the distal end of the catheter and over at least a portion of the transparent treatment region. An elongate energy transmission wire is configured to transmit activation energy from a proximal end thereof to a distal end thereof. The activation system has a configuration in which the balloon is expanded, the energy transmission wire is received within the medical device lumen such that the distal end of the energy transmission wire is within the transparent treatment region, and activation energy is emitted from the energy transmission wire, through the transparent treatment region, through the balloon, and toward the inactive agent. | 11-27-2014 |
20140350456 | ELECTROPORATION APPLIANCE COMPRISING AN OBLONG APPLICATOR, RING ELECTRODES AND A SEAT FOR A SYRINGE - A dynamic electroporation appliance comprises an oblong isolating applicator ( | 11-27-2014 |
20140358069 | METHOD AND APPARATUS FOR DERMATOLOGICAL TREATMENT AND TISSUE RESHAPING - The present invention provides improved methods and apparatus for skin treatment and tissue remodeling. The apparatus includes an array of needles that penetrate the skin and serve as electrodes to deliver radio frequency current or other electrical or optical energy into the tissue being treated, causing thermal damage in controlled patterns. The damaged regions promote beneficial results such as uniform skin tightening by stimulation of wound healing and collagen growth. | 12-04-2014 |
20140364798 | Indwelling Nerve Block Catheters - A nerve block catheter system employs an indwelling, flexible catheter comprising a tissue lock to retain the catheter tip in pharmacologically proximity to a target nerve and optionally, a decoupler that insulates the tip of the catheter from proximal tissue movement. | 12-11-2014 |
20140371665 | METHOD AND APPARATUS FOR CANCER TREATMENT - An apparatus for treating solid tumors having at least one hollow needle having at least one perforation, at least one ground electrode, a pump for delivering a chemotherapeutic agent through the perforation in the hollow needle, one or more power supplies connected to the hollow needle and the ground electrode capable of delivering a pulse of alternating current between the hollow needle and the ground electrode of at least 1000 volts and no more than 1 millisecond duration, a direct current between the hollow needle and the ground electrode between about 1 mA and 100 mA, and a second alternating current having a frequency range between about 1 MHz and 1000 MHz. | 12-18-2014 |
20140378890 | APPARATUS AND METHOD FOR DELIVERING INTRALUMINAL THERAPY - A catheter and methods for luminal therapy are provided wherein a catheter has an outer balloon with a multiplicity of apertures for infusing one or more therapeutic agents into a vessel wall, an intermediate balloon having a multiplicity of apertures offset from the apertures of outer balloon to serve as a baffle that reduces jetting and promotes uniform distribution of therapeutic agent exiting through the outer balloon, and an impermeable inner balloon disposed within the intermediate balloon that enables the intermediate and outer balloons to be forced into engagement with the vessel wall to dilate the vessel and disrupt plaque lining the vessel wall and to also facilitate the uniform delivery of the therapeutic agent. The outer balloon may include protrusions that contact the vessel wall to disrupt the plaque, bumpers to reduce washout during infusion of therapeutic agents; the intermediate balloon may include a texture, ribs or protrusions on its outer surface to prevent adhesion to the outer balloon during dilation of the vessel; and the catheter may include a guide wire lumen sized to accept an energy delivery device to delivery energy that enhances uptake of the therapeutic agent or prolongs therapeutic effectiveness of the agent. | 12-25-2014 |
20150011928 | METHOD AND APPARATUS FOR AUTOMATED ACTIVE STERILIZATION OF FULLY IMPLANTED DEVICES - The current invention provides this advance in infection control via its unique application of active sterilization to a catheter or implant. While most catheters, and many implants, are passive devices, the current invention will provide an active component as a integral part of the implanted catheter or device to continuously or intermittently sterilize the exposed surfaces/areas of the device. This active sterilization may be accomplished by a variety of mechanisms, including, application of heat, RF, microwave, ultrasound, ultraviolet radiation or other energy capable of sterilizing the device or dislodging any problematic Biofilm that may form. The active sterilization may also employ the pumping of a sterilizing chemical from all attached drug reservoir, the use of electricity or freezing temperatures or any other mechanism for either inhibiting, killing or dislodging any infectious material in contact with the implant. One major advantage of this design is that through the use of small, battery powered or inductively powered sterilization element, the implanted catheter or device can be effectively sterilized without requiring the standard removal surgery, waiting period, then replacement of the infected device. This is expected to translate into greatly improved outcomes (particularly for devices where infection may be catastrophic, ie a prosthetic knee or hip), greatly improved costs, and greatly improved longevity of susceptible devices (ie IV ports, etc.). | 01-08-2015 |
20150018753 | SYSTEMS AND METHODS FOR IN VIVO IRRADIATION OF BLOOD - Systems and methods for illumination of a vascular space and its contents using an electromagnetic energy source that supplies a plurality of wavelengths ranging from ultraviolet to infrared are shown. Illumination can be performed using multiple wavelengths, simultaneously or sequentially, and can be performed in accordance with a protocol where an initial illumination produces an effect that is at least partially reversed by a subsequent illumination. Illumination protocols can be stored on a database and accessed via a user interface displayed on the electromagnetic energy source. The database can be used to store data related to performance of system components, and such data can be used to override or modify an illumination protocol. | 01-15-2015 |
20150025444 | LASER-ASSISTED TRANSDERMAL DELIVERY OF NANOPARTICULATES AND HYDROGELS - Methods and systems for laser assisted delivery of therapeutic agents include preparing a site with an ultraviolet laser beam, at a wavelength appropriate for tissue ablation, such that an opening is produced in a surface of the site's tissue; and applying one or more agents to the prepared site, such that the agents penetrate the tissue through the opening to a predetermined depth. | 01-22-2015 |
20150025445 | LASER-ASSISTED TRANSDERMAL DELIVERY OF NANOPARTICULATES AND HYDROGELS - Systems for laser assisted delivery of therapeutic agents include an ultraviolet laser configured to produce a laser beam at a wavelength appropriate for tissue ablation; a lens configured to focus and direct the laser beam to a site, such that an opening is produced in a surface of the site's tissue; a nozzle having an aperture that emits the laser beam and that controls delivery of one or more agents to the site; and an imaging device configured to monitor a depth of penetration of the one or more agents into the site's tissue. | 01-22-2015 |
20150032046 | ENERGY-BASED TREATMENT METHODS FOR REFRACTORY GOUT - A method of performing a medical procedure is disclosed. The method includes: positioning an energy delivery device configured to deliver energy adjacent uric acid (UA) crystals having a resonance frequency; applying energy to tissue through the energy delivery device at a predetermined frequency thereby resonating the UA crystals; debulking at least a portion of the UA crystals; and removing at least a portion of the debulked UA crystals. | 01-29-2015 |
20150057599 | PULMONARY ARTERY ABLATION CATHETER - A multi-pole synchronous pulmonary artery radiofrequency ablation catheter, wherein an adjustment apparatus is arranged on a control handle; a catheter body is hollow, and a cavity is arranged therein; a lead wire, a temperature sensing wire and a pull wire are arranged in the cavity; one end of the catheter body is flexible, and the flexible end is connected to an annular ring; the other end of the catheter body is connected to the control handle; one end of the pull wire is connected to the flexible end, and the other end of the pull wire is connected to the adjustment apparatus on the control handle, the tension of the pull wire is adjusted through the adjustment apparatus to achieve radian control of the flexible end; a shape memory wire is arranged in the annular ring, one end of the shape memory wire extends to the end of the annular ring and the other end of the shape memory wire passes through the root of the annular ring and is fixed on the flexible end of the catheter body; the annular ring is provided with an electrode group with each electrode connected to the lead wire and temperature sensing wire; the lead wire and temperature sensing wire go through the catheter body and are electrically connected to the control handle. The device uses cold saline perfusion method to protect the vascular intima and possesses advantages of simple operation, short operation time and controllable precise ablation. The device can be used to treat pulmonary hypertension with pulmonary denervation. | 02-26-2015 |
20150065944 | DRUG-DELIVERY DEVICE FOR USE WITH ABLATION DEVICE - A drug-delivery device includes a body configured for attachment to a handle of an ablation device, a shaft portion defining a passageway therein, and a delivery lumen to provide for drug delivery to tissue. The body includes a proximal portion, a distal portion, and a contoured portion disposed therebetween. The contoured portion is configured for engagement with a contoured portion of the handle of the ablation device. The shaft portion includes a proximal end and a distal end. The proximal end of the shaft engages with an opening defined in the distal end of the body. The passageway of the shaft portion is configured to receive the delivery lumen slideably moveably therein. The delivery lumen includes a proximal portion and a distal portion. The drug-delivery device also includes a knob member coupled to the proximal portion of the delivery lumen. | 03-05-2015 |
20150065945 | SPINAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS - Methods for treating a patient using therapeutic spinal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including modulating nerves of one or more targeted organs proximate one or more dorsal root ganglia, stellate ganglia, vertebral ganglia, or cervical ganglia of the nerves using an intravascularly-positioned therapeutic element. One or more measurable physiological parameters corresponding to at least one condition associated with sympathetic activity in the targeted organs and/or central sympathetic activity in the patient can thereby be reduced. | 03-05-2015 |
20150073330 | ALZHEIMER'S DISEASE TREATMENT WITH MULTIPLE THERAPEUTIC AGENTS DELIVERED TO THE OLFACTORY REGION THROUGH A SPECIAL DELIVERY CATHETER AND IONTOPHORESIS - This invention describes the administration of multiple therapeutic agents with insulin in conjunction with bexarotene, ketamine, monoclonal antibodies Etanercept, IGF-1, and acetylcholine esterase inhibitors physostigmine, for treatment of Alzheimer's disease and other neurodegenerative diseases. Insulin, improves memory; also augments and amplifies the effects of the adjuvant therapeutic agents (paracrine and intracrine effects) and consequently reduces the β amyloid, its soluble precursors, prevents damage to the neuronal skeletal network (taupathy), and blocks glutamate excitotoxicity, reduces brain inflammation, prevents apoptosis, and increases the acetylcholine levels in the neurons and synapses; by using a combination of insulin, bexarotene, ketamine, Etanercept, IGF-1, and physostigmine therapeutic agents. The results are achieved by using the specially designed Iontophoresis incorporated olfactory mucosal delivery (ORE) catheter device located at the olfactory nerves, sphenoid sinus, and adjacent structures described here, to transport the large molecules of therapeutic agents to treat AD delivered to the CNS bypassing BBB from ORE. | 03-12-2015 |
20150080785 | ALZHEIMER'S DISEASE TREATMENT WITH MULTIPLE THERAPEUTIC AGENTS DELIVERED TO THE OLFACTORY REGION THROUGH A SPECIAL DELIVERY CATHETER AND IONTOPHORESIS - This invention describes the administration of multiple therapeutic agents with insulin in conjunction with bexarotene, ketamine, monoclonal antibodies Etanercept, IGF-1, and acetylcholine esterase inhibitors physostigmine, for treatment of Alzheimer's disease and other neurodegenerative diseases. Insulin, improves memory; also augments and amplifies the effects of the adjuvant therapeutic agents (paracrine and intracrine effects) and consequently reduces the β amyloid, its soluble precursors, prevents damage to the neuronal skeletal network (taupathy), and blocks glutamate excitotoxicity, reduces brain inflammation, prevents apoptosis, and increases the acetylcholine levels in the neurons and synapses; by using a combination of insulin, bexarotene, ketamine, Etanercept, IGF-1, and physostigmine therapeutic agents. The results are achieved by using the specially designed Iontophoresis incorporated olfactory mucosal delivery (ORE) catheter device located at the olfactory nerves, sphenoid sinus, and adjacent structures described here, to transport the large molecules of therapeutic agents to treat AD delivered to the CNS bypassing BBB from ORE. | 03-19-2015 |
20150094645 | APPARATUS FOR APPLICATION OF A PULSED RADIO FREQUENCY THERAPY IN A VASCULAR SYSTEM OR ANOTHER CAVITY OR TISSUE OF THE HUMAN OR ANIMAL BODY - The invention relates to an apparatus for application of a pulsed radio frequency therapy in a vascular system or another cavity or tissue of the human or animal body comprising a catheter with at least one electrode disposed thereon for insertion into the vascular system or another cavity or the tissue of the human or animal body; a probe with at least one further electrode disposed thereon, wherein the probe is insertable via the catheter into the vascular system or the other cavity or the tissue of the human or animal body; and a generator electrically connected with the electrodes for generating a pulsed electro-magnetic field between the electrodes. | 04-02-2015 |
20150119792 | LIGHT DEGRADABLE DRUG DELIVERY SYSTEM FOR OCULAR THERAPY - A system and method for delivering a payload to ocular tissue includes a solution of light-degradable nanoparticles encapsulating the payload. The solution may be introduced to the ocular tissue by way of injection or through a contact lens into which the solution is embedded. A light source delivers a beam of light to the ocular tissue at the location where the solution was introduced to initiate breakdown of the particles, releasing the payload. The light source may be a laser, LED, LCD or arc lamp emitting in the ultraviolet light range. | 04-30-2015 |
20150119793 | APPARATUS AND METHOD FOR TREATING A NEUROMUSCULAR DEFECT - A method is provided for treating a neuromuscular defect in a subject. One step of the method includes locating a target nerve. After locating the target nerve, a treatment probe is provided. The treatment probe includes an elongated body member having a proximal end portion and a distal end portion. The distal end portion includes an energy delivery mechanism for stimulating or ablating the target nerve, a monitoring mechanism, and a fluid aspiration/delivery mechanism. Next, the target nerve is verified as an appropriate target for ablation by stimulating and then monitoring the target nerve via the energy delivery mechanism and the monitoring mechanism, respectively. After verifying the target nerve, a tumescent fluid is injected into the tissue surrounding the target nerve. An electric current is then delivered to the energy delivery mechanism to substantially ablate the target nerve. | 04-30-2015 |
20150119794 | METHODS TO REGULATE POLARIZATION AND ENHANCE FUNCTION OF CELLS - Methods and compositions to controllably regulate cells at a target site. A quantum dot-targeting agent complex is administered to a patient in need of therapy, and the complex is stimulated using an implanted fiber optic system. In embodiments, the system includes an electrical sensor that detects and monitors electrical activity of the stimulated controllably regulated cells, and relays this information to a controller that can regulate further stimulation. | 04-30-2015 |
20150126922 | COAXIAL DUAL FUNCTION PROBE AND METHOD OF USE - An energy delivery probe for use in tissue ablation and method of use is presented. The energy delivery device has at least a first energy delivery member and a second energy delivery member that have handle members positioned along a longitudinal axis, each handle member having a proximal and distal end. The distal end of the first handle member is releasably coupled to the proximal end of the second handle member and a portion of each member is defined in a coaxially surrounding relationship to each other along the longitudinal axis. The method of using the probe involves identifying a tissue to be ablated, providing the energy delivery probe, inserting at least a portion of the energy delivery probe into the identified tissue, delivering electrical energy through the energy delivery probe to the identified tissue, and ablating the identified tissue such that at least a first ablation zone is formed. | 05-07-2015 |
20150133850 | SELECTIVE MODULATION OF RENAL NERVES - Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including selectively neuromodulating afferent or efferent renal nerves. One or more measurable physiological parameters corresponding to systemic sympathetic overactivity or hyperactivity in the patient can thereby be reduced. Selectively neuromodulating afferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a renal pelvis. This can include, for example, neuromodulating via fluid within the renal pelvis. Selectively neuromodulating efferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a portion of a renal artery or a renal branch artery proximate a renal parenchyma. This can include, for example, neuromodulating via a therapeutic element within the portion of the renal artery or the renal branch artery. | 05-14-2015 |
20150314063 | DELIVERY OF A THERAPEUTIC FLUID - Systems, methods and devices for delivering a therapeutic fluid into tissue are disclosed. The system includes an infusion set having a catheter for delivery of a dose of therapeutic fluid into a tissue via an infusion tube, a treatment element that applies treatment to the tissue proximate to the catheter, a catheter adaptor having a first transponder, a pump adaptor, in communication with the catheter adaptor, having a second transponder that communicates with the first transponder, and an infusion detection sensor that detects an infusion of the therapeutic fluid. Upon detection of an infusion of the therapeutic fluid by the infusion detection sensor, the second transponder communicates a signal indicative of the detected infusion to the first transponder causing the catheter adaptor to apply treatment using the treatment element. At least one of a strength and a duration of the treatment corresponds to a dose of the infused therapeutic fluid. | 11-05-2015 |
20150320998 | Device, system and method for killing viruses in blood - A device, system and method for killing viruses in blood. An iontophoretic terminal delivery system includes a smart catheter, aleated electrode within the smart catheter, a terminal and an electrical system. Ultrasound cannulation is used to guide the smart catheter of the iontophoretic terminal delivery system into a vein of the patient. Electrical power is provided to the aleated electrode of the smart catheter, thereby releasing positively charged ionized silver nanoparticles into the blood stream that attract negatively charged viruses in order to effectively destroy them. The smart catheter includes two micro fluid chips, a Lab On Chip that counts viral loads as well as patient progress in real time, and a Polymerase Chain Reaction chip, which checks for other viruses or infections. Collected data is passed to the terminal where it is stored and made available in a digitized format. Together these chips form a redundant biosensing system. | 11-12-2015 |
20150359995 | Over-the-Needle Catheter Insert - The present disclosure is directed to an over-the-needle (OTN) catheter assembly having a structural member configured therein. The OTN catheter assembly includes a catheter coaxially mounted onto a needle. In one embodiment, the structural member includes a coil insert that is embedded into an interior wall of the catheter, thereby preventing kinking of the catheter when being inserted within a patient. In another embodiment, the structural member may be a separate and removable coil insert that is inserted into the catheter after the OTN catheter assembly has been placed in a targeted site within the patient and the needle is removed. In a further embodiment, the structural member may be a separate and removable solid insert having a blunt distal end that is inserted into the catheter after the OTN catheter assembly has been placed in a targeted site within the patient and the needle is removed. Thus, the structural member is capable of advancing the catheter to one or more targeted sites within the patient, if desired, without causing further discomfort to the patient. | 12-17-2015 |
20160015930 | CONVECTION ENHANCED DELIVERY DEVICE AND SYSTEM - A convection enhanced delivery device comprises a support member and an elongated microcatheter carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit carried by the support member. The fluid conduit includes a conduit lumen that extends in a second direction different than the first direction. The conduit lumen is in fluid communication with the catheter lumen. An inlet port and a connecting port are also carried by the support member. The inlet port is in fluid communication with the fluid conduit. The connecting port is separate from the inlet port and is in fluid communication with the fluid conduit. The connecting port is configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member. | 01-21-2016 |
20160038591 | METHOD AND APPARATUS FOR BOOSTING VACCINE EFFICACY - A method and an system for vaccinating a mammalian subject. The method includes the steps of: arranging a source of electromagnetic radiation proximate to a target zone of skin of the mammalian subject; controlling the source of electromagnetic radiation to deliver a dose of electromagnetic radiation to the target zone determined to create one or more thermally-denatured zones in the target zone; and intradermally injecting a vaccine within the target zone to vaccinate the mammalian subject. The system for vaccinating a subject may include an electromagnetic radiation source configured to be arranged proximate to a target zone on an exterior of the subject; a user control configured to selectively cause the electromagnetic radiation source to deliver a dose of electromagnetic radiation toward the target zone to create one or more thermally-denatured zones in the target zone; and a vaccine-delivery system configured to deliver a vaccine to the target zone. | 02-11-2016 |
20160051806 | Ductus side-entry jackets and prosthetic disorder response systems - Provided are means for the direct and continuous connection of a catheter to the lumen of any tubular anatomical structure, or ductus, without medically significant leakage. A port implanted at the body surface with piping to a periductal collar allows drug or radionuclide delivery that bypasses the upstream lumen. The port allows injection, infusion, or attachment of an automatic ambulatory pump. A superparamagnetic nanoparticle carrier-bound drug, for example, can be introduced into the lumen to pass downstream until the carrier particles, with or without the drug still bound, are drawn into the lumen wall by a magnetized jacket surrounding the ductus. Such constitutes a method of drug targeting whereby a segment of a vessel or the territory supplied by a branch of that segment can be circumscribed for exposure to the drug. A jacket with side-entry connector positioned in surrounding relation to a lesion requiring treatment can itself be magnetized. | 02-25-2016 |
20160095597 | RAPID CLOSING SURGICAL CLOSURE DEVICE - A surgical or wound closure device utilizes a slide fastener for rapidly closing a surgical incision or wound with precise apposition of the sides of the incision. The surgical closure devices are configured for linear incisions, shaped incisions, such as used for wedge biopsy or excisional biopsy, and long incisions, such as used for laparotomy or surgical removal of redundant skin. The surgical closure device may be adhered to the patient's skin prior to making an incision and is subsequently used for closing the incision. | 04-07-2016 |
20160106931 | RAPID CLOSING SURGICAL CLOSURE DEVICE - A surgical or wound closure device utilizes a slide fastener for rapidly closing a surgical incision or wound with precise apposition of the sides of the incision. The surgical closure devices are configured for linear incisions, shaped incisions, such as used for wedge biopsy or excisional biopsy, and long incisions, such as used for laparotomy or surgical removal of redundant skin. The surgical closure device may be adhered to the patient's skin prior to making an incision and is subsequently used for closing the incision. | 04-21-2016 |
20160129155 | MUSCULOSKELETAL TISSUE FABRICATION - Described herein are methods of fabricating human cell-based engineered musculoskeletal tissues (hCEMTs) using three dimensional fabrication technology that involves injectable materials with in situ polymerization/solidification capability and/or solid free-form fabrication. Also described is the usage of hCEMTs for tissue repair and drug testing. | 05-12-2016 |
20160143776 | A DEVICE FOR DELIVERY OF COMPOSITIONS TO THE EYE - The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle. | 05-26-2016 |
20160183821 | FLEXIBLE ELECTRODE TIP WITH HALO IRRIGATION - The instant disclosure relates generally to a tip electrode for delivering irrigant to a distal portion of the tip electrode and irrigated catheter tips incorporating such a tip electrode. The distal portion of the tip electrode can have additional fluid ports on the distal edge of the tip to provide additional fluid flow to that region. | 06-30-2016 |
20160193388 | ELECTROCHEMICAL DISINFECTION OF IMPLANTED CATHETERS | 07-07-2016 |
20160193477 | System and Method for Treating a Vein | 07-07-2016 |