Class / Patent application number | Description | Number of patent applications / Date published |
600368000 | Physical characteristics of blood | 25 |
20080228058 | Apparatus and Method for Detecting the Reproductive Status, in Particular the Oestrus Cycle, of a Mammal - An apparatus for detecting the reproductive status, in particular the oestrus cycle, of a mammal, comprising detecting means ( | 09-18-2008 |
20080249388 | SYSTEMS AND METHODS FOR COOLING OF INTRAVENOUS FLUID AND MONITORING OF IN VIVO CHARACTERISTICS - Intravenous sensor systems and methods for determining in vivo characteristics are disclosed, as well as systems for cooling bags of intravenous fluid. The intravenous sensor systems include a probe configured for placement in a peripheral vein. The probe includes one or more sensors for obtaining sensed information, such as body temperature, blood oxygen saturation level and blood pressure. An interface unit determines the in vivo characteristics based upon sensed information received from the one or more sensors. The determined in vivo characteristics may be displayed on the interface unit and/or transmitted to a remote computer. | 10-09-2008 |
20080275325 | Evanescent Catheter System - An evanescent catheter system is provided as a system having a structure of a tip portion of an optical fiber capable of securely measuring a fluorescence intensity or fluorescence spectrum of a substance around a catheter tip, without being hindered by optical absorption of hemoglobin in erythrocytes in blood, and being capable of calculating an existing amount of a fluorescence-emitting substance existing in an evanescent light generating part. A protecting layer | 11-06-2008 |
20100030054 | CEREBRAL VASCULAR REACTIVITY MONITORING - A monitoring device may include logic to receive arterial blood pressure data associated with a patient and receive tissue hemoglobin data associated with the patient. The logic may also calculate a linear correlation between the arterial blood pressure data and the tissue hemoglobin data. The correlation may be used to assess vascular reactivity. | 02-04-2010 |
20100081912 | Ultrasound-Optical Doppler Hemometer and Technique for Using the Same - According to embodiments, a sensor assembly and/or systems for ultrasound-optical measurements may provide information related to hemodynamic parameters. An ultrasound beam may be used to generate a Doppler field for optical elements of a sensor assembly. By combining information received from ultrasound and optical elements of the sensor assembly, more accurate values for hemodynamic parameters may be determined. | 04-01-2010 |
20100198037 | FEEDBACK SENSOR FOR REAL-TIME MANAGEMENT OF SICKLE CELL DISEASE - Described herein are devices, systems and methods for real-time (or near real-time) monitoring of red blood cell morphology, and in particular, monitoring of sickling to provide an indication of the risk of a the downstream consequences of sickling, such as the pain crises and associated hypoxic tissue damage which may occur as sickling progresses. The monitors describe herein may be continuous (e.g., sampling the subject continuously while worn or activated), or they may operate at a predetermine or selectable sampling rate. In some variations, the devices described herein are worn or applied to the patient non-invasively or minimally invasively. | 08-05-2010 |
20110060205 | System For The Noninvasive Determination Of Tracer Concentration In Blood - The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (C | 03-10-2011 |
20110077496 | PROCESS AND APPARATUS FOR NON-INVASIVE, CONTINUOUS IN VIVO MEASUREMENT OF HEMATOCRIT - The invention provides a method and apparatus obtaining a hematocrit from a sample of in vivo tissue. The method comprises irradiating the sample with a single incident wavelength on a sample of tissue, simultaneously measuring wavelength shifted (IE) and unshifted (EE) light emitted from the tissue, and determining a relative volume of light emitted from two phases, wherein the two phases comprise a first Rayleigh and Mie scattering and fluorescent phase associated with red blood cells, and a second, non-scattering phase associated with plasma. The hematocrit is calculated from the volume of light emitted by the first phase relative to the total volume of light emitted from the first and second phases. | 03-31-2011 |
20110196219 | Fetal Scalp Blood Analyzer - A hand-held analyzer for collecting a sample of blood from the scalp of a fetus and measuring the pH of the blood sample. The analyzer includes a probe with a blunt proximal end that facilitates a firm and positive placement of the probe against the scalp. The probe includes a capillary tube for collecting blood and an extensible lancet which at rest is positioned within the capillary tube. During operation, the lancet is extended to make an incision in the scalp. The lancet then retreats, and blood flows into the capillary tube. Sensors for measuring pH are in liquid communication with the capillary tube. A display on or near the hand-held analyzer shows a readout of the fetal scalp blood pH. Measuring the pH of the fetal scalp blood in utero can provide early detection of acidosis and likely hypoxia. | 08-11-2011 |
20120190955 | Intelligent drug delivery appliance - A system, method and apparatus for real time measurement and monitoring of various personal health parameters including controlled delivery of drugs/medications by intelligent pump appliances, intelligent inhalation appliances and intelligent skin patch appliances used in a standalone manner or in a wired or wireless networked configuration, in conjunction with various peripheral devices, other intelligent appliances, servers, RF ID Tags and stationary/mobile devices. The intelligent appliances relate to the measurement, monitoring and delivery of insulin/other drugs for the treatment of diabetes and other diseases. The method also additionally includes the application of intelligent appliances for pain management including visualization of organs and body locations exhibiting pain. | 07-26-2012 |
20130018245 | METHOD AND APPARATUS FOR EVALUATING VALUES REPRESENTING A MASS OR A CONCENTRATION OF A SUBSTANCE PRESENT WITHIN THE BODY OF A PATIENTAANM Chamney; PaulAACI HertsAACO GBAAGP Chamney; Paul Herts GBAANM Moissl; UlrichAACI Bad VilbelAACO DEAAGP Moissl; Ulrich Bad Vilbel DEAANM Wabel; PeterAACI DarmstadtAACO DEAAGP Wabel; Peter Darmstadt DEAANM Nier; VolkerAACI ReichelsheimAACO DEAAGP Nier; Volker Reichelsheim DEAANM Wieskotten; SebastianAACI Ober-RamstadtAACO DEAAGP Wieskotten; Sebastian Ober-Ramstadt DE - The present invention relates to a method for evaluating a value representing the mass or the concentration of a substance comprised by a tissue or a bodily fluid of a patient, the method including the steps of a) determining a relation between one or more calculated or measured value(s) reflecting the mass or the concentration and a distribution space of the patient or an approximation thereof, and b) assessing whether the relation fulfils a criterion. The present invention further relates to systems and computer programs for performing this method. | 01-17-2013 |
600369000 | Coagulation | 14 |
20080294029 | System to Measure Blood Coagulation Related Parameters - System to measure blood coagulation related parameters comprising one first channel ( | 11-27-2008 |
20090093697 | MEMS INTERSTITIAL PROTHROMBIN TIME TEST - A method of determining a prothrombin time is disclosed. A mediator is applied to a stratum corneum. The stratum corneum is penetrated to allow the mediator to enter a region containing interstitial fluid and interact with at least one capillary, causing blood and/or blood components to leak from the at least one capillary into the region containing interstitial fluid. A characteristic affected by the blood and/or blood components is measured in the region containing interstitial fluid which correlates to the prothrombin time. A system for measuring prothrombin time is also disclosed. The system has a mediator, one or more microneedles, and a processor directly or indirectly coupled to the one or more microneedles and configured to determine a coagulation change in blood or blood components in a region around the one or more microneedles after the one or more microneedles penetrate a stratum corneum. | 04-09-2009 |
20090198120 | Detection of restenosis risk in patients receiving a stent by measuring the characteristics of blood clotting including the measurement of maximum thrombin-induced clot strength - A method of selecting a stent for implantation in the circulatory system of a human being includes the steps of determining a threshold level of platelet hyper-coaguability (PHC). One marker of PHC is platelet-fibrin mediated clot strength (MA) of blood. MA above a threshold demonstrates a risk of restenosis that is relatively high. In practicing the method, a sample of blood is obtained from a patient who requires implantation of a stent, the blood sample is tested for its platelet-fibrin mediated clot strength, the clot strength of the blood sample is compared with the threshold level; if the blood sample has a clot strength below the threshold level, selecting a bare metal stent, and if the blood sample has a clot strength at or above the threshold level, selecting a drug-eluting stent. The method includes, in a preferred embodiment, use of a viscoelastic monitor to perform the testing step. Other markers of PHC may also be employed such as measurement of thrombin generation and/or platelet reactivity. | 08-06-2009 |
20100121171 | METHOD OF MEASURING BLEEDING VOLUME - A method of measuring blood clotting ability of a patient. A known volume of blood is dispensed on a reference disc of blotter paper, such that at least one reference blotch is formed on the reference disc. The surface area of the reference blotch formed on the reference disc, such that a relationship between the volume of blood and the surface area of the reference blotch can be obtained. An incision is made at the patient. A piece of blotter paper to the incision is applied to the incision to collect blood flowing therefrom, such that at least one blotch is formed on the piece of blotter paper. The surface area of the blotch formed on the piece of blotter paper is measured. The volume of the blood absorbed blood by the blotter paper is calculated according to the relationship between the blood volume and the surface area of the blotch. | 05-13-2010 |
20100286497 | Method and Apparatus for Determining One or More Blood Parameters From Analog Electrical Signals - Embodiments of the present invention relate to a system and method for in vivo measurement of blood parameters by processing analog electrical signals from a plurality of photodetectors. In some embodiments, it is possible to determine one or more blood parameters according to (i) a first electrical signal from a first detector and (ii) a second electrical signal from a second photodetector. A difference analog electrical signal is generated, indicative of a difference between the light response signal at the first location and light response signal at the second location, is generated. One or more blood parameters may be detected according to the difference analog electrical signal. | 11-11-2010 |
20110112390 | APPARATUS AND METHOD FOR BLOOD CLOTTING DIAGNOSTICS - In order to be able still more precisely to determine the blood clotting activity in a patient according to the invention there is provided a method of extracorporeal determination of the blood clotting activity of a blood sample of an individual, in which the clotting time which elapses until the blood sample reaches a given degree of clotting or the degree of clotting reached by the blood sample within a given time is measured or in which in a corresponding manner the fibrinolysis time or the degree of fibrinolysis of a blood sample which has previously clotted to a certain degree is measured, the method being characterised in that measurement of the clotting/fibrinolysis time or the degree of clotting/fibrinolysis is effected with the exclusion of air. In addition according to the invention there is proposed a corresponding apparatus for the extracorporeal determination of the blood clotting activity wherein the apparatus has a measurement chamber for measuring the clotting time, the degree of clotting, the fibrinolysis time or the degree of fibrinolysis of a blood sample, the apparatus being characterised in that the measurement chamber is of such a configuration that measurement of the clotting/fibrinolysis time or the degree of clotting/fibrinolysis is effected with the exclusion of air. | 05-12-2011 |
20120035450 | BLOOD COAGULATION SYSTEM ANALYZER, AND BLOOD COAGULATION SYSTEM ANALYSIS METHOD AND PROGRAM - A blood coagulation system analysis device capable of analyzing a blood coagulation system with high accuracy, and a method and a program for analysis of a blood coagulation system are proposed. | 02-09-2012 |
20120130215 | Optical measurement of parameters related to motion of light-scattering particles within a fluid by manipulating analog electrical signals - The present invention relates to an apparatus and method for optical measurement of a parameter related to motion of light-scattering particles within a fluid by manipulating analog electrical signals. In some embodiments, first and second analog signals are respectively obtained from first and second photodetectors respectively located at first and second locations. A technique is disclosed for boosting a fraction of an analog electrical signal attributable to light scattering fluctuations and/or to stochastic effects and/or to speckle measurements and/or to DLS measurements. According to this technique, a hybrid analog signal or a difference analog signals is obtained from the first and second analog signals, and is analyzed. Exemplary fluids include but are not limited to biological fluids (e.g. blood plasma). Teachings disclosed herein may be employed in vitro or in vivo. | 05-24-2012 |
20130190584 | METHOD AND APPARATUS FOR CHARACTERIZATION OF CLOT FORMATION - Methods, apparatus and systems for characterizing changes in at least one physical property of soft tissue. A series of acoustic pulses is generated and directed into the soft tissue such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the tissue. Waves reflected off the tissue, or a flexible member that moves with the tissue, are received and measured to estimate at least one characteristic of the physical displacement induced thereby. Repetition of the generating, receiving and estimating steps provides characterization of the at least one physical property over time. Methods, apparatus and systems for characterizing at least one physical property of blood, by generating a series of acoustic pulses and directing the series of pulses into the blood such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the blood. Acoustic pulses and/or optical waves reflected from the blood, or a flexible member in contact with the blood that moves with the blood, are received and measured to estimate at least one characteristic of the physical displacement induced thereby. | 07-25-2013 |
20130310672 | METHOD OF MEASURING BLEEDING VOLUME - A method of measuring blood clotting ability of a patient. A known volume of blood is dispensed on a reference disc of blotter paper, such that at least one reference blotch is formed on the reference disc. The surface area of the reference blotch formed on the reference disc, such that a relationship between the volume of blood and the surface area of the reference blotch can be obtained. An incision is made at the patient. A piece of blotter paper to the incision is applied to the incision to collect blood flowing therefrom, such that at least one blotch is formed on the piece of blotter paper. The surface area of the blotch formed on the piece of blotter paper is measured. The volume of the blood absorbed blood by the blotter paper is calculated according to the relationship between the blood volume and the surface area of the blotch. | 11-21-2013 |
20140128707 | METHOD OF PREDICTING A BLOOD DILUTION RISK VALUE - The present invention provides for a clinical decision support system which makes use of a numerical model which dynamically describes a blood dilution of a blood circulation. Based on measured coagulation data and maybe other patient information, loss of hemostatic balance is predicted based on calculations of certain protein concentrations. Additionally, a calculation arrangement translates at least some of the calculated values of concentrations of human blood proteins into a risk value which risk value describes a risk of clotting and/or embolism and/or bleeding. A time development of that risk value is displayed to the user. | 05-08-2014 |
20140364712 | NANOENHANCED HEMOSTATIC DEVICE AND METHODS FOR MAKING A LAYER HAVING HEMOSTATIC PROPERTIES - Devices and methods relate to inducing or promoting hemostasis. The hemostasis device may include a support layer having a first surface and an opposing second surface. The device may include a layer, the layer disposed on the first surface. The layer may include a target surface configured to contact a target site. The layer may include a monolayer of about 100% graphene or may include laser-reduced graphene oxide. The device may include a sensor configured to measure a level of hemostasis of the target site. The methods relate to a method of manufacturing a hemostatic device including a monolayer of graphene or a layer of laser-reduced graphene oxide. | 12-11-2014 |
20150025348 | Assessing Coagulation - Devices and methods for assessing coagulation include a channel configured such that shear stress, in a first portion of the channel, applied to blood drawn through the channel by a vacuum-tube attached to an outlet of the channel approximates physiological shear stresses. | 01-22-2015 |
20150305681 | Optical Blood-Coagulation Sensor - Hand-held optical thromboelastographic sensor and method of using the same for simultaneous assessment of multiple parameters of blood coagulation at a point-of-care. The sensor includes an optical system registering laser speckle intensity associated with a stationary blood sample and data-processing circuitry programmed to derive the multiple parameters from speckle intensity. The circuitry may be part of a mobile device configured to operate without communication with a central server and/or data storage. | 10-29-2015 |