Class / Patent application number | Description | Number of patent applications / Date published |
564384000 | The aryl ring or ring system and amino nitrogen are bonded directly to the same acyclic carbon, which carbon additionally has only hydrogen or acyclic hydrocarbyl substituents bonded directly thereto | 23 |
20090326272 | Method for Producing Optically Active 1-(Fluoro-, Trifluoromethyl- or Trifluoromethoxy-Substituted Phenyl) Alkylamine N-Monoalkyl Derivative - There is provided a method for producing an optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative, which includes the steps of conducting reductive alkylation of an optically active secondary amine and a formaldehyde (including an equivalent thereof) or lower aldehyde in the presence of a transition metal catalyst under a hydrogen gas atmosphere, thereby converting the secondary amine to an optically active tertiary amine of the formula, and subjecting the tertiary amine to hydrogenolysis. The target optically active compound can be produced efficiently by this production method. | 12-31-2009 |
20110092739 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules - The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, dsRNA, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, to relevant cells and/or tissues, such as in a subject or organism. Such novel cationic lipids, microparticles, nanoparticles and transfection agents are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism. The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP). | 04-21-2011 |
20140073815 | AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH A CYCLIC GROUP - This invention provides a compound of the formula (I): | 03-13-2014 |
20150094492 | PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE - The present invention relates to a process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine by hydrogenation of N-[(5-chloro-2-isopropylphenyl)methylene]cyclopropanamine over specific platinum catalysts. | 04-02-2015 |
20160002146 | METHOD FOR PRODUCING HALOGEN-N,N-DIMETHYLBENZYLAMINES - The invention relates to a method for producing halogen-N,N-dimethylbenzylamines wherein halogen=chlorine or bromine, preferably chloro-N,N-dimethylbenzylamines, preferably ortho-chloro-N,N-dimethylbenzylamine (o-Cl-DMBA), by reductive amination in the absence of sulfur. | 01-07-2016 |
564385000 | Forming amine group directly by reduction, other than by reductive amination | 3 |
20090192334 | Process for producing highly purified xyltlenediamine - A method of producing xylylenediamine from xylene. In the method, xylene is converted into dicyanobenzene by ammoxidation. The produced dicyanobenzene is extracted into an organic solvent. The extract is then distilled to separate dicyanobenzene from the organic solvent. After added with a solvent, the separated dicyanobenzene is hydrogenated in a liquid phase. Finally, the hydrogenation product is purified by distillation to obtain a highly pure xylylenediamine. The method is conducted in a simple and low energy-consuming process. | 07-30-2009 |
20120142968 | Nitrogen and Hindered Phenol Containing Dual Functional Macromolecular Antioxidants: Synthesis, Performances and Applications - Disclosed are compounds represented by structural formula (I): | 06-07-2012 |
20140316163 | NITROGEN AND HINDERED PHENOL CONTAINING DUAL FUNCTIONAL MACROMOLECULAR ANTIOXIDANTS: SYNTHESIS, PERFORMANCES AND APPLICATIONS - Disclosed are compounds represented by structural formula (I): | 10-23-2014 |
564386000 | Forming directly by amination which replaces halogen or forming amine group directly by hydrolysis | 2 |
20120123163 | PROCESS FOR THE PREPARATION OF 2,2-DIFLUOROETHYLAMINE STARTING FROM A BENZYLAMINE COMPOUND - Process for the preparation of 2,2-difluoroethylamine of the formula (I) | 05-17-2012 |
20130046111 | Method for the Hydrolysis of Substituted Formylamines into Substituted Amines - An improved method for the synthesis of substituted formylamines and substituted amines via an accelerated Leuckart reaction. The Leuckart reaction is accelerated by reacting formamide or N-alkylformamide and formic acid with an aldehyde or a ketone at a preferred molar ratio that accelerates the reaction. The improved method is applicable to various substituted aldehydes and ketones, including substituted benzaldehydes. An accelerated method for the hydrolysis of substituted formylamines into substituted amines using acid or base and a solvent at an elevated temperature. The improved method is useful for the accelerated synthesis of agrochemicals and pharmaceuticals such as vanillylamine, amphetamine and its analogs, and formamide fungicides. | 02-21-2013 |
564387000 | The aryl ring or ring system is polycyclo | 7 |
20090216047 | Purification process - Purification process for the preparation of the allylamine pharmaceutical terbinafine of formula I | 08-27-2009 |
20100267988 | PROCESSES FOR PREPARING INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF CINACALCET - The invention relates, in general, to an improved process for preparing compounds (e.g., 3-(3-trifluoromethylphenyl)propanal (Compound III, below)), which are key intermediates for the synthesis of cinacalcet, its salts and/or solvates thereof, as well as the use of such compounds prepared by such process for the preparation of cinacalcet and/or its salts or solvates. | 10-21-2010 |
20110105799 | PROCESS FOR THE SYNTHESIS OF CINACALCET HYDROCHLORIDE - There is described a process for the preparation of cinacalcet hydrochloride (I) which includes the steps of: a) reacting (R)-(+)-1-(1-naphthyl)ethylamine (II) with 3-[3-(trifluoromethyl)phenyl]propenaldehyde (III) to afford the non isolated intermediate (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino-N-[1-(1-naphthyl)ethylamine (IV); b) reducing the non isolated intermediate (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino-N-[-1-(1-naphthyl)ethylamine (IV) with a sequential addition of:—a solution of sodium borohydride, methanol and a base,—oxalic acid and − a base to obtain (R)—N-[3[3-(tifluoromethyl)phenyl]-2-propenyl]-1-(1-naphthyl)ethylamine (V) by passing through the precipitation of the oxalate salt of compound (V) after the addition of oxalic acid; c) hydrogenating (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenyl]-1-(1-naphthyl)ethylamine (V) thus obtaining (R)—N-(3-(3-(trifluoromethyl)phenyl]propyl]-1-(1-naphthyl)ethylamine cinacalcet base (VI), which is retaken in ethyl acetate; and d) treating the solution of cinacalcet base (VI) in ethyl acetate with hydrochloric acid to afford cinacalcet hydrochloride (I). | 05-05-2011 |
20110295037 | PROCESSES FOR PREPARING CINACALCET HYDROCHLORIDE AND POLYMORPHIC FORMS THEREOF - The invention relates to cinacalcet hydrochloride, new polymorphic crystalline forms of cinacalcet hydrochloride, amorphous cinacalcet hydrochloride and synthetic processes for their preparation. | 12-01-2011 |
20130178654 | PROCESS FOR CINACALCET HYDROCHLORIDE - 3-[3-(Trifluoromethyl)phenyl]propionaldehyde is a key intermediate for the preparation of cinacalcet hydrochloride. The present invention provides a novel process for the preparation of 3-[3-(trifluoromethyl)phenyl]propionaldehyde. The present invention also provides an improved process for preparation of cinacalcet hydrochloride in high yields. The present invention further provides a process for purification of cinacalcet hydrochloride. | 07-11-2013 |
20150080608 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE - Method for preparing cinacalcet hydrochloride having the steps of heating (R)-1-naphthyl ethylamine (Formula I) and 3-(trifluoromethyl)benzene (Formula II) | 03-19-2015 |
20160023987 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS - The present invention relates to fungicidal benzocycloalkene carboxamides or their thiocarboxamide derivatives of formula (I), their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. | 01-28-2016 |
564388000 | Plural amino methylene groups bonded directly to the same benzene ring | 2 |
20130296609 | METHOD FOR PRODUCING XYLYLENEDIAMINE - Provided is a method for stably and economically producing xylylenediamine with a high yield and long catalyst service life by hydrogenating dicyanobenzene that is obtained by ammoxidating xylene. By bringing an aqueous basic solution into contact with a dicyanobenzene-absorbed liquid, which is obtained by bringing an ammoxidation reaction gas into contact with an organic solvent, under specified temperature conditions, and subjecting a base and a carboxylic acid in the dicyanobenzene-absorbed liquid to a neutralization reaction so as to form an aqueous phase that contains a water-soluble salt, and then subjecting an organic phase and the aqueous phase to liquid-liquid separation so as to remove the aqueous phase, it is possible to remove the carboxylic acid contained in the dicyanobenzene-absorbed liquid with high selectivity while inhibiting loss of the dicyanobenzene. By subjecting the raw material dicyanobenzene, which is obtained by separating low boiling point compounds from the post liquid-liquid separation organic phase by distillation under reduced pressure, to hydrogenation, xylylenediamine is produced with a high yield and the service life of the hydrogenation catalyst is extended. | 11-07-2013 |
20130303805 | PRODUCTION METHOD FOR AMINO COMPOUND - The present invention relates to a process for producing an amino compound by subjecting a polyamine and an alkenyl compound to addition reaction in the presence of an alkali metal hydride compound which is capable of supplying the amino compound in a stable manner without occurrence of odor. | 11-14-2013 |
564389000 | Benzyl amines having hydroxy or ether oxygen bonded directly to the benzene ring (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal) | 2 |
564390000 | Ortho hydroxy benzyl amines | 2 |
20110040125 | NITROGEN AND HINDERED PHENOL CONTAINING DUAL FUNCTIONAL MACROMOLECULAR ANTIOXIDANTS: SYNTHESIS, PERFORMANCES AND APPLICATIONS - Disclosed are compounds represented by structural formula (I): | 02-17-2011 |
20130217919 | ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS - Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds. | 08-22-2013 |
564391000 | Benzyl amines wherein the benzene ring has no other substituents | 2 |
20080262268 | Crystallization Method for Benzphetamine - There is disclosed a method for the crystallization of benzphetamine hydrochloride from an organic medium by the steps of removing water from the system to a very low level and then reducing the temperature of the organic medium to provide crystallization of the acid salt. In the event that crystallization does not occur upon lowering the temperature of the medium, it has been discovered that gentle heating of the organic medium results in crystallization of the acid salt. It has also been discovered that higher temperature crystallization has been provided by removal of methamphetamine from the composition. The crystalline benzphetamine hydrochloride can then be isolated by typical liquid/solid separation means such as filtration or centrifugation. | 10-23-2008 |
20160176803 | PROCESS FOR THE ETHERIFICATION OF AMINO ALCOHOLS AT LOW TEMPERATURES | 06-23-2016 |