Class / Patent application number | Description | Number of patent applications / Date published |
564192000 | Substituent Q is acyclic | 62 |
20100010261 | PRODUCTION OF AMINES - A process for the hydrogenation of carboxylic acids and/or derivatives, particularly amides, is described. The process includes reacting an acid or derivative such as an amide with a source of hydrogen in the presence of a catalyst system. The catalyst system obtainable by combining: (a) a source of ruthenium, and (b) a phosphine compound of general Formula I: (Formula I). The hydrogenation reaction is carried out in the presence of a low concentration of water or at low pressure or in the presence of a source of ammonia or the hydrogenation reaction is carried out in the absence of water or a combination of these factors is utilised. The invention also relates to the use of ammonia in the production of primary amines by hydrogenation of carboxylic acids and/or derivatives thereof or a process for the production of primary amines generally. | 01-14-2010 |
20100094053 | USE OF PERSONAL CARE COMPOSITION - Use of an alkyl monoethanolamide having an alky chain length from 10 to 14 for the manufacture of a composition for the treatment of scalp itch. | 04-15-2010 |
20120046496 | METHOD FOR PURIFYING GLYCERIN AND PRODUCTS OBTAINED THEREFROM - A method and system for purifying crude glycerin is provided in which a mixture is formed by blending glycerin, water, an organic solvent, and an acid. The acid being capable of reacting with soap impurities to form lipids that are soluble in the organic solvent and ionic salts that are soluble in the glycerin and water. Liquid-liquid extraction separates and partitions the organic solvents and lipids away from the glycerin, water, and ionic salts with the organic solvent and lipids being reclaimed for future use. Any residual trace amount of organic solvent that remains in the glycerin and water is separated and removed through the use of a clarifier system, with the formation of micro-bubbles arising from a diffuser facilitating the separation. Prior to collection of the purified glycerin product, the ionic salts are removed from the mixture through the use of an ionic exchange resin, electrodialysis, or electrodeionization, followed by the water being removed by evaporation. The resulting purified glycerin exhibits a purity level on the order of about 99.7% or more. | 02-23-2012 |
20150011794 | KETOXIME- AND AMIDE-FUNCTIONALIZED NANOMATERIALS - Ketoxime- and amide-functionalized nanomaterials. The nanomaterials including a nanomaterial comprising a carbon nanotube or a carbon nanofiber. At least one ketoxime group coupled to a first location on the nanomaterial, and at least one amide group coupled to a second location on the nanomaterial. | 01-08-2015 |
564193000 | Nitrogen in substituent Q | 5 |
564194000 | Benzene ring in a substituent E | 2 |
20090306429 | PREPARATION OF A QUATERNARY AMMONIUM HYDROXIDE AND USE THEREOF FOR THE PREPARATION OF A QUATERNARY AMMONIUM SALT - The invention relates to a process for the preparation of a quaternary ammonium hydroxide, in particular denatonium hydroxide, and the use thereof for the preparation of a quaternary ammonium salt, in particular of denatonium benzoate or a denatonium fatty acid derivative. Due to its extremely bitter taste, this latter compound is applied in the art as an aversive agent, biocide, antifoulant and flavorant. It is usually prepared from a quaternary ammonium halide in an organic environment, which after isolation and purification is converted to a hygroscopic and unstable hydroxide intermediate, which in turn is immediately converted to the salt of interest in the solvent in which it is prepared. It is now found that these isolation steps can be avoided by performing the reaction at aqueous conditions. This is more straightforwardly and does not require costly precautions to avoid contact while handling. Moreover, the process of the invention allows to produce the quaternary ammonium salt from a lignocaine compound in a one-pot synthesis involving mostly water. | 12-10-2009 |
20100076224 | NOVEL TRIHALOMETHIONINE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING THE SAME - A compound represented by the formula (I) is used as an active ingredient in a medicament for treatment or prevention of infectious diseases caused by protozoa or bacterium. | 03-25-2010 |
564197000 | The compound is acyclic | 3 |
20090124832 | OLIGOAMINE COMPOUNDS AND DERIVATIVES THEREOF FOR CANCER THERAPY - Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers. | 05-14-2009 |
20090312577 | Process for Production of Beta-Amino-Alpha-Hydroxy Carbonxamide Derivative - Provided is a process for production of a β-amino-α-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a β-(N-protected)amino-α-hydroxycarboxylic acid is reacted with an amine to conversion to a β-(N-protected)amino-α-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a β-amino-α-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity β-amino-α-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process. | 12-17-2009 |
20100094054 | COMPOSITION FOR EXTERNAL APPLICATION TO SKIN - The present invention provides a composition for external application to skin containing one type or two or more types of compounds selected from the group consisting of aminoacetoamide compounds represented by the following general formula (1) and salts thereof. | 04-15-2010 |
564199000 | Carbonyl in substituent Q | 2 |
20110087051 | Alkylene Oxide-Adducted Hydrocarbyl Amides - Provided herein are products produced by:
| 04-14-2011 |
564200000 | Benzene ring in a substituent E | 1 |
20110105795 | PROCESS FOR PREPARATION OF TERIFLUNOMIDE - The present invention provides a process for preparing Teriflunomide of formula (I). | 05-05-2011 |
564201000 | Hydroxy, bonded directly to carbon, or ether in substituent Q (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal) | 4 |
20090221853 | PROCESS FOR THE PREPARATION OF 2-CHLOROETHOXY-ACETIC ACID-N,N-DIMETHYLAMIDE - According to the present invention, 2-chloroethoxy-acetic acid-N,N-dimethylamide of the Formula (I) is prepared by reacting 2-hydroxyethoxy-acetic acid-N,N-dimethylamide of the Formula (II) in a solvent optionally in the presence of a catalyst with thionyl chloride and removing the solvent by distillation. | 09-03-2009 |
20120302791 | ETHER-AMIDE COMPOUNDS AND USES THEREOF - Novel ether-amide compounds are described. Uses of the compounds, in particular as solvents, for example in phytosanitary formulations are also described. | 11-29-2012 |
20160046762 | METHOD FOR PURIFYING POLYETHYLENE GLYCOL HAVING ONE AMINO GROUP - A method for purifying a polyethylene glycol compound having one amino group, which includes (A) preparing an aqueous solution of the compound having a pH of 1 to 5, (B) an extracting step of mixing the aqueous solution with a mixed organic solvent to cause layer separation into organic and aqueous layers, wherein a ratio of an organic solvent I is 25 to 65% by mass and a ratio of an organic solvent II is 75 to 35% by mass, the organic solvent I is selected from an aromatic hydrocarbon and an ester, the organic solvent II is a halogenated hydrocarbon, and a mixing ratio Y of I to II, temperature T (° C.) at mixing, and molecular weight M of the compound satisfy the following relationship: | 02-18-2016 |
20160200669 | METHOD FOR RECOVERING FLUORINATED EMULSIFIER | 07-14-2016 |
564204000 | Carbon to carbon unsaturation in substituent Q | 4 |
20090149674 | METHOD FOR THE CONTINUOUS PRODUCTION OF ALKYL AMINO ACRYL AMIDES - The invention relates to a method for the continuous production of alkyl amino acryl amides by reacting alkyl acrylates with high-boiling amines. A specific preparation technique is used in order to achieve hitherto unobtainable product qualities. Very high spatial, temporal and overall yields can also be obtained. | 06-11-2009 |
20140187818 | BACTERIAL STRAIN RHODOCOCCUS AETHERIVORANS VKM Ac-2610D PRODUCING NITRILE HYDRATASE, METHOD OF ITS CULTIVATION AND METHOD FOR PRODUCING ACRYLAMIDE - The invention relates to a bacterial strain belonging to the genus | 07-03-2014 |
20150315619 | METHOD FOR PRODUCING AMIDE COMPOUND - The invention pertains to a technique for suppressing a decrease in nitrile hydratase activity and improving the productivity of the amide compound in the course of producing an amide compound from a nitrile compound using a biocatalyst. Specifically, the invention pertains to a method for producing the corresponding amide compound from a nitrile compound in the presence of a biocatalyst having nitrile hydratase activity, wherein the method for producing an amide compound using a nitrile compound is characterized in that the zinc concentration of the nitrile compound is 0.4 ppm or less. | 11-05-2015 |
564206000 | Purification or recovery | 1 |
20090287020 | PROCESS FOR PRODUCING HIGH-PURITY N-VINYLCARBOXAMIDES - Disclosed is a process for producing high-purity N-vinylcarboxamides comprising: (A) a step of dissolving a crude N-vinylcarboxamide in an alcohol having 1 to 3 carbon atoms, the crude N-vinylcarboxamide containing 50 to 97% by mass of an N-vinylcarboxamide; (B) a step of adding an aliphatic hydrocarbon having 5 to 10 carbon atoms to the composition obtained in the step (A) to precipitate a crystal of the N-vinylcarboxamide; and (C) a step of separating the crystal of the N-vinylcarboxamide precipitated in the step (B). | 11-19-2009 |
564209000 | Halogen, bonded directly to carbon, in substituent Q | 8 |
20090043130 | Fluoroalkyl surfactants - A compound of formula (I): | 02-12-2009 |
20110054217 | HYDROGENATION OF IMINES - The present invention relates to a process for the asymmetric hydrogenation of imines with hydrogen under elevated pressure in the presence of a catalyst system. In particular the present invention relates to the use of the said catalytic system for the enantioselective hydrogenation of prochiral ketimines to asymmetric amines leading to the formation of herbicides. | 03-03-2011 |
20140221689 | PERFLUOROPOLYETHER URETHANE ADDITIVES HAVING (METH)ACRYL GROUPS AND HARD COATS - Fluorocarbon- and urethane-(meth)acryl-containing additives and hardcoats. The hardcoats are particularly useful as a surface layer on an optical device. | 08-07-2014 |
564210000 | Ring in a substituent E | 5 |
20090082596 | Process for the Preparation of Adamantanamines - The invention relates to a process for preparing certain adamantanamines, of formula | 03-26-2009 |
564211000 | Benzene ring in a substituent E | 4 |
20140018578 | NEW METHOD FOR THE SYNTHESIS OF RASAGILINE - We have developed a new method for the synthesis of Rasagiline (Formula 1) based on the alkylation of trifluoroacetyl protected aminoindan. This protection enabled us to carry out an alkylation of aminoindan with a high yield and purity under very mild conditions with a wide range of reaction conditions and reagent selection. Considering the ease, purity and high yields of introducing and removal of the trifluoroacetyl group, this approach is a highly practical and economical way for the synthesis of rasagiline or its pharmaceutically acceptable salts. | 01-16-2014 |
564212000 | A ring or polycyclo ring system in a substituent E is attached indirectly to the carboxamide nitrogen or to an amino nitrogen in substituent E by acyclic nonionic bonding | 2 |
20080293969 | 18F-Labeled Daa Analogues and Method of Labeling These Analogues as Positron Emission Tomography (Pet) Tracers For Imaging Peripheral Benzodiazepine Receptors - Methods for selecting novel DAA analogues for a peripheral type benzodiazepine receptor were labeled with | 11-27-2008 |
20090043131 | Process for the Preparation of Florfenicol - The present invention relates to a method for the preparation of Florfenicol from Fluoroamine compound, namely (1R,2S)-1-[4-(methylsulfonyl)phenyl]-2-amino-3-fluoro-1-propanol (II), by reaction with dihaloacetic acid ester in an organic solvent in presence of an inorganic base. | 02-12-2009 |
564214000 | The compound is monocyclic | 1 |
20090036713 | PROCESS FOR THE HYDROGENATION OF IMINES - The present invention relates to a process for the hydrogenation of imines with hydrogen in the presence of iridium catalysts. In particular the present invention relates to a process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of an iridium catalysts and with or without an inert solvent, wherein the reaction mixture comprises a phosphonium chloride, bromide or iodide in the presence or in the absence of an acid, which can be an organic or inorganic acid, soluble or insoluble in the reaction mixture. Suitable imines are especially those that contain at least one (Formula I) group. If the groups are substituted asymmetrically and are thus compounds having a prochiral ketimine group, it is possible in the process according to the invention for mixtures of optical isomers or pure optical isomers to be formed if enantioselective or diastereoselective iridium catalysts are used. | 02-05-2009 |
564215000 | Q is hydrogen or a lower saturated alkyl substituent | 35 |
20080207949 | Method For The Production Of N,N-Dimethylacetamide (Dmac) - A process for preparing N,N-dimethylacetamide (DMAC) by continuously reacting methyl acetate (MeOAc) with dimethylamine (DMA) in the presence of a basic catalyst, wherein MeOAc is used in the form of a methanolic solution which is obtained as a by-product in the preparation of polyTHF by transesterifying polyTHF diacetate with methanol. | 08-28-2008 |
20090143622 | Method For The Synthesis Of Substituted Formylamines And Substituted Amines - An improved method for the synthesis of substituted formylamines and substituted amines via an accelerated Leuckart reaction. The Leuckart reaction is accelerated by reacting formamide or N-alkylformamide and formic acid with an aldehyde or a ketone at a preferred molar ratio that accelerates the reaction. The improved method is applicable to various substituted aldehydes and ketones, including substituted benzaldehydes. An accelerated method for the hydrolysis of substituted formylamines into substituted amines using acid or base and a solvent at an elevated temperature. The improved method is useful for the accelerated synthesis of agrochemicals and pharmaceuticals such as vanillylamine, amphetamine and its analogs, and formamide fungicides. | 06-04-2009 |
20110004020 | PROCESS FOR PRODUCING ORGANIC CARBOXYLIC ACID AMIDES - The present invention relates to a process for producing organic carboxylic acid amides by nitrile hydrolysis of a nitrile compound at certain temperature and pressure in the presence of a catalyst to produce an organic carboxylic acid amide. | 01-06-2011 |
20110082316 | METHOD FOR THE PRODUCTION OF N,N-DIMETHYLACETAMIDE (DMAC) - A process for preparing N,N-dimethylacetamide (DMAC) by continuously reacting methyl acetate (MeOAc) with dimethylamine (DMA) in the presence of a basic catalyst, wherein MeOAc is used in the form of a methanolic solution which is obtained as a byproduct in the preparation of polyTHF by transesterifying polyTHF diacetate with methanol. | 04-07-2011 |
20120010430 | METERING RING - The present invention relates to an apparatus for metering flowable media or gases, and to the use thereof. | 01-12-2012 |
20130079556 | SILVER-CATALYZED SYNTHESIS OF AMIDES FROM AMINES AND ALDEHYDES - The invention provides a method for producing amides via the reaction of aldehydes and amines with oxygen adsorbed on a metallic silver or silver alloy catalyst. An exemplary reaction is shown in Scheme 1 : (I), (II), (III) | 03-28-2013 |
564216000 | Purification or recovery | 2 |
20100240927 | METHOD FOR PREPARATION OF PARTICLES - The present invention relates to a new method for preparing micron-sized particles which comprises introducing in the particle formation vessel a solute solution in a solvent and a compressed fluid under supercritical conditions, wherein the vessel in which the particles are formed is at a pressure comprised between atmospheric pressure and 15 bar. The particles obtained present a small size, a limited size distribution, and low agglomeration. Particles with suitable fluidity can furthermore be prepared from products, for example, pharmaceutical active ingredients and/or excipients, with a low glass transition temperature. | 09-23-2010 |
20120071691 | METHOD FOR SEPARATING A MIXTURE COMPRISING THREE COMPONENTS BY SIMULATED MOVING BED CHROMATOGRAPHY - A method for separating a mixture of components by simulated moving bed chromatography: (1) feeding the simulated moving bed such that the eluting power of the liquid phase in the second zone is greater than that of the liquid phase in the third zone, trapping the target component inside the second and the third zone; (2) a solvent for dissolving the mixture to be separated, instead of the feeding solution, is fed into the simulated moving bed through the feeding port, and the eluting power of the liquid phase in the second zone is maintained greater than that of the liquid phase in the third zone, thereby both the pre-impurity and the post-impurity are rinsed off completely, and the target component trapped in the second and the third zone is further purified; and (3) the target component trapped in the simulated moving bed is rinsed off the bed. | 03-22-2012 |
564217000 | Ring in a substituent E | 27 |
20090299096 | Amidoadamantanes and Method for Producing the Same - The invention relates to 1-formamido-adamantane derivatives of formula (I), which carry the substituents R | 12-03-2009 |
20090299097 | Method for Producing 1-Formamido-3,5-Dimethyladamantane - The invention relates to a method for producing 1-formamido-3,5-dimethyladamantane in only two reaction steps by direct formamide formation of 1,3-dimethyladamantane, the 1,3-dimethyladamantane being reacted with formamide in concentrated acids. | 12-03-2009 |
20110082317 | PROCESS FOR THE MANUFACTURE OF MEMANTINE AND INTERMEDIATE PRODUCT. - The present invention relates to a process for manufacturing N-Formyl-1-amino-3,5-dimethyladamantane, an intermediate product in the overall process of producing 1-Amino-3,5-dimethyladamantane hydrochloride (Memantine). Therein, the process comprises the following steps:
| 04-07-2011 |
20150105587 | Amorphous Amides - An amorphous amide compound of the formula | 04-16-2015 |
564218000 | Benzene ring in a substituent E | 23 |
20090216046 | SELECTIVE ACYLATION OF 4-SUBSTITUTED-1,3-PHENYLENEDIAMINE - This invention is directed to a method of selectively acylating a compound of formula (II): (II), wherein: R | 08-27-2009 |
20100160683 | Process for Production of 2-(Substituted Phenyl)-3,3,3-Trifluoropropene Compound - There is provided a novel process for production of a 2-(substituted phenyl)-3,3,3-trifluoropropene. | 06-24-2010 |
20120245388 | 4-(TRICHLOROMETHYLTHIO) ANILINES, METHOD FOR PRODUCTION THEREOF, AND METHOD FOR PRODUCING 4-(TRIFLUOROMETHYLTHIO) ANILINES - There are provided a 4-(trichloromethylthio)aniline represented by the general formula (II): | 09-27-2012 |
20120253072 | PROCESS FOR THE PREPARATION OF AROMATIC FORMAMIDES - The invention relates to a process for the preparation of formamides by reacting aromatic amines with a formic acid ester in the presence of a catalyst, wherein the catalyst is a phosphorus-containing acid or a Lewis-acidic metal salt. | 10-04-2012 |
564219000 | A ring or polycyclo ring system in a substituent E is attached indirectly to the carboxamide nitrogen or to an amino nitrogen in substituent E by acyclic nonionic bonding | 9 |
20080207950 | Enantioselective Synthesis of a Sterically Hindered Amine - Compounds of the formula (I) wherein R is phenyl, or phenyl substituted by Cl, Br, C | 08-28-2008 |
20090299098 | Catalytic Metathesis of Secondary Amides - The invention provides methods and reagents for the metathesis of secondary amides via a transacylation mechanism employing catalytic quantities of an imide initiator and a Brønsted base. Equilibrium-controlled exchange between various amide reactant pairs is demonstrated for substrates bearing a variety of N-alkyl and N-aryl substituents. | 12-03-2009 |
20100036165 | Process for obtaining the crystalline form V of agomelatine - Process for obtaining the crystalline form V of the compound of formula (I): | 02-11-2010 |
20110313198 | AGOMELATINE HYDROHALIDE COMPLEX AND PREPARATION METHOD THEREOF - The present invention relates to a complex of agomelatine and to preparation thereof. The hydrogen halide complex of agomelatine obtained through the present method is more soluble, more stable, and of higher purity than agomelatine itself, making it more suitable to be used in pharmaceutical preparation. Using this method, product of high purity can be obtained through a simple process, without having to incur further complicated steps. | 12-22-2011 |
20130245321 | SPHINGOSINE KINASE TYPE 1 INHIBITORS - Provided are novel compositions and analogs which are useful in a number of applications, indications and diseases, as well as for monitoring pharmakinetics and patient management. These compounds and analogs are applicable to treating tumors of the central nervous system, e.g., glioblastoma (GBM). | 09-19-2013 |
20130289308 | PROCESS FOR THE SYNTHESIS OF AGOMELATINE - Process for the industrial synthesis of the compound of formula (I) | 10-31-2013 |
20140051887 | PHARMACEUTICALLY ACCEPTABLE COCRYSTALS OF N-[2-(7-METHOXYL-1-NAPHTYL)ETHYL]ACETAMIDE AND METHODS OF THEIR PREPARATION - The present invention relates to novel solid forms of agomelatine (I), specifically novel phaamaceutically acceptable cocrystals thereof, as well as to methods of preparing them. Three pharmaceutically acceptable cocrystals of (I) that have physico-chemical properties acceptable for pharmaceutical development were obtained. | 02-20-2014 |
20140221690 | PROCESS FOR THE PREPARATION OF CRYSTALLINE FORMS OF AGOMELATINE AND NOVEL POLYMORPH THEREOF - The invention concerns a new process for the preparation of two crystalline forms of agomelatine, in particular a process for preparation of form I and a new form of agomelatine, here called form VII. | 08-07-2014 |
20150291508 | PROCESS FOR THE PREPARATION OF CRYSTALLINE FORM OF AGOMELATINE - The invention concerns a new process for the preparation of crystalline form I of agomelatine by freeze-drying. | 10-15-2015 |
564221000 | Plural rings in a substituent E | 10 |
20090156862 | Formoterol Tartrate Process and Polymorph - A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. | 06-18-2009 |
20090234162 | Radioactive Halogen-Labeled Phenyloxyaniline Derivatives - A radioactive halogen-labeled phenyoxyaniline derivative represented by the following formula: wherein R | 09-17-2009 |
20100125150 | CRYSTALLINE FORM OF A BETA2 ADRENERGIC RECEPTOR AGONIST - The invention provides a novel β | 05-20-2010 |
20100249459 | Formoterol Tartrate Process and Polymorph - A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. | 09-30-2010 |
20110092736 | Process for Preparing Substituted Biphenylanilides - The present invention relates to a process for preparing substituted biphenylanilides of the formula I | 04-21-2011 |
20110105796 | Tetraarylborate Process for the Preparation of Substituted Biphenyls - The present invention relates to a process for the preparation of substituted biphenyls by reacting aryl halides with tetraarylborates in the presence of palladium catalysts. | 05-05-2011 |
20110313199 | PROCESSES FOR PREPARING SUBSTANTIALLY PURE ARFORMOTEROL AND ITS INTERMEDIATES - Provided herein are improved, convenient and industrially advantageous processes for the preparation of N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (Arformoterol) or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided further herein is an improved and industrially advantageous process for the preparation of a substantially enantiomerically pure arformoterol intermediate, (R)-4-methoxy-α-methyl-N-(phenylmethyl)benzeneethanamine. | 12-22-2011 |
20130296607 | Acetamide Stereoisomer - The compound of formula (I) | 11-07-2013 |
20160083334 | PROCESS FOR THE PREPARATION OF ARFORMOTEROL OR SALT THEREOF - Provided is an improved process for the preparation of arformoterol L-(+)-tartrate, and more specifically provided is a novel process for the preparation of arformoterol L-(+)-tartrate via arformoterol D-(−)-tartrate. | 03-24-2016 |
564222000 | Polycyclo ring system in a substituent E | 1 |
20110263900 | PROCESS FOR MANUFACTURING ADAMANTANE DERVATIVES WITH HIGH YIELD - The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reacting said substituted 1-bromo-adamantane with an amide, wherein the substituted 1-bromo-adamantane is used in the form of a mixture comprising bromine as obtained in step (0), wherein in step (0) a bromine:substituted adamantane molar ratio of from [2.5:1] to less than [5:1] is employed. | 10-27-2011 |