Class / Patent application number | Description | Number of patent applications / Date published |
564124000 | Preparing directly from cyano containing compound | 23 |
20080306299 | Method for the Production of Aminoalkane Acid Amides - The invention relates to a process for preparing aminoalkanamides by reacting cyanoalkanoic esters with a) ammonia or an amine and b) hydrogen in the presence of a catalyst, the reaction with component b) being started simultaneously or not later than a maximum of 100 minutes after commencement of the reaction of the cyanoalkanoic ester with component a). | 12-11-2008 |
20080319226 | Process For the Preparation of Highly Pure (E) N,N-Diethyl-2-Cyano-3-(3,4-Dihydroxy-5-Nitro Phenyl) Acrylamide (Entacapone) - A process for the preparation of highly pure (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide (Entacapone). It comprises condensing 3,4-dihydroxy-5-nitro benzaldehyde with N,N-diethyl cyano acetamide in an organic solvent in the presence of an organic base and an acid under reflux conditions followed by distilling off the solvent under vacuum and treating the residue with a lower aliphatic carboxylic acid at 40-8O0 C. The resulting residue is extracted with a chlorinated solvent and the solvent is distilled off under vacuum. The resulting residue is extracted with an organic solvent to obtain crude N,N-diethyl-2-cyano-3-3,4-dihydroxy-5-nitrophenyl)acrylamide. The crude product N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) acrylamide formed is treated with a mixture of organic alcohol and organic acid in the molar ratio of the crude product to organic alcohol 1:5 to 15 and crude product to organic acid 1:1 to 3 under reflux conditions. | 12-25-2008 |
20090118544 | Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine - A process for the industrial synthesis of the compound of formula (I) | 05-07-2009 |
20100036161 | Process for the synthesis of agomelatine - Process for the industrial synthesis of the compound of formula (I) | 02-11-2010 |
20110295035 | METHOD FOR PRODUCING PHENYLACETAMIDE COMPOUND - A method for producing a phenylacetamide compound represented by formula (1): | 12-01-2011 |
20130267738 | AGOMELATINE INTERMEDIATES AND PREPARATION METHOD THEREOF - The present invention relates to the intermediate compounds for preparation of agomelatine, as well as the preparation methods thereof. The intermediate of the present invention for preparation of agomelatine is compound A as shown in the following formula. Also provided are two novel intermediate compounds. When we use these new intermediate compounds to prepare agomelatine, it is simple to manipulate, well-controlled and with high purity, without complicated operations such as rectification and column chromatography separation, and suitable for industrial production. Meanwhile, the preparation methods of the two new intermediates themselves is simple and high yield, only using the most commonly-used 7-methoxy-tetralone as original starting material and undergoing one step of reaction to obtain the intermediates, followed by one more step of converting the intermediate compounds to desired product agomelatine. Said reaction processes are greatly simplified, with the reaction yield being improved and the difficulty in purification of previous method being overcome, as compare with the previous technique for preparation of agomelatine. Typically, the yield of the present invention is over 70%. | 10-10-2013 |
20130289307 | PROCESS FOR THE SYNTHESIS OF AGOMELATINE - Process for the industrial synthesis of the compound of formula (I) | 10-31-2013 |
564125000 | From HCN or cyanogen | 1 |
20100234640 | Method for controlling multiple pollutants - This invention provides a comprehensive solution which comprises the production of a bed of ash-containing hot char via the pyrolysis of coal which generates a hydrogen rich gas that, subsequent to its cleanup, can be synthesized into chemicals and/or transportation fuels, while the hot char is used to: (i) reduce SO | 09-16-2010 |
564126000 | Catalytic hydration only of nitrile | 6 |
20100331574 | HYDROXYAPATITE WITH SILVER SUPPORTED ON THE SURFACE THEREOF - An object of the present invention is to provide a hydroxyapatite with silver supported on the surface thereof, a new compound useful as a catalyst for the reaction of producing an amide compound by hydration of the corresponding nitrile compound. | 12-30-2010 |
20110021819 | PROCESS FOR PRODUCTION OF AMIDE COMPOUNDS - The present invention provides a method for producing an amide compound from a nitrile compound using a biocatalyst that realizes low cost, energy saving and low environmental burdens. The production method of the amide compound of the present invention is a method for producing an amide compound from a nitrile compound using a biocatalyst in a reactor, wherein the nitrile compound is reacted with the biocatalyst to produce the amide compound under such stirring conditions that the stirring power requirement is in the range of 0.08 to 0.7 kW/m | 01-27-2011 |
20130041179 | AMIDE COMPOUND PRODUCTION CATALYST, AND PROCESS FOR PRODUCTION OF AMIDE COMPOUND - The present provides a high-efficiency amide compound production catalyst to be used in producing an amide compound through hydration of a nitrile compound and a production method using it. The amide compound production catalyst is for producing an amide compound through reaction of a nitrile compound and water, and comprises a manganese oxide catalyst containing bismuth and further containing yttrium or vanadium. The method for producing an amide compound comprises reacting a nitrile compound and water in a liquid phase in the presence of the amide compound production catalyst. | 02-14-2013 |
20130096344 | NITRILE HYDRATION CATALYZED BY RECYCLABLE RUTHENIUM COMPLEXES - A method for hydrating a nitrile derivative to generate an amide derivative is provided. The method includes mixing the nitrile derivative with a ruthenium catalyst complex in an aqueous solution to form a mixture, and reacting the nitrile derivative with water in the aqueous solution and in the presence of the ruthenium catalyst complex to form a reacted mixture comprising the amide derivative. The ruthenium catalyst complex is represented by the following structural formula: RuX | 04-18-2013 |
20160102046 | PROCESSES FOR THE SYNTHESIS OF 2-AMINO-4,6-DIMETHOXYBENZAMIDE AND OTHER BENZAMIDE COMPOUNDS - This invention provides a method for the synthesis of a 2-amino-4,6-dimethoxybenzamide and other benzamides of Compound I: wherein R | 04-14-2016 |
20160145196 | METHOD FOR PRODUCING A-HYDROXYISOBUTYRIC ACID AMIDE AND REACTOR - The present invention provides a method for producing α-hydroxyisobutyric acid amide by hydration of acetone cyanohydrin under the presence of a catalyst composed mainly of manganese oxide using a reactor in which at least two reaction regions are connected in series, the method being characterized by comprising: a step (B) of cyclically supplying at least a portion of a reaction liquid withdrawn from at least one reaction region to a first reaction region (I) in the reactor; and a step (b1) of further cyclically supplying at least a portion of the reaction liquid withdrawn from at least one reaction region to at least one reaction region other than the first reaction region. The method is also characterized in that an oxidizing agent is supplied to at least one reaction region in the reactor. | 05-26-2016 |
564129000 | Acid hydrolysis only of nitrile | 2 |
20120130127 | METHOD OF PREPARING 1-CHLOROACETAMIDO-1,3,3,5,5-PENTAMETHYLCYCLOHEXANE - Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, an intermediate in the synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof, comprising step (iii):
| 05-24-2012 |
20130211140 | METERING RING - The present invention relates to an apparatus for metering flowable media or gases, and to the use thereof. | 08-15-2013 |
564130000 | From acyclic nitrile | 7 |
20090131719 | Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine - A process for the industrial synthesis of the compound of formula (I) | 05-21-2009 |
20100217042 | PROCESS FOR WORKING UP DIACETONE ACRYLAMIDE SOLUTIONS FOR THE PREPARATION OF PURE DIACETONE ACRYLAMIDE - Improved process for working up diacetone acrylamide solutions, obtained by reaction of acetone or diacetone alcohol with acrylonitrile and sulfuric acid and subsequent dilution and neutralization, in which a) the organic phase obtained subsequent to the neutralization, which comprises the crude diacetone acrylamide, is hydrolyzed by addition of an aqueous alkaline solution in order to remove acrylamide, then b) after phase separation has been carried out, the organic phase, which comprises the crude diacetone acrylamide, is neutralized by addition of an acid, and c) in succession, low-boiling-point byproducts are removed by distillation in the presence of one or more polymerization inhibitors, then t-butylacrylamide is removed by distillation and, finally, the diacetone acrylamide is isolated by product distillation, and d) the diacetone acrylamide thus obtained is converted into its final form | 08-26-2010 |
20110245539 | PROCESS FOR THE PREPARATION OF N-VINYLCARBOXAMIDES - Process for the preparation of N-vinylcarboxamides by pyrolysis of a compound of the formula | 10-06-2011 |
20150148564 | PROCESS FOR PREPARING 2,2-DIBROMOMALONAMIDE - The present invention generally relates to a process for preparing 2,2-dibromomalonamide from 2,2-dibromo-3-cyanoacetamide. | 05-28-2015 |
564131000 | Which contains carbon to carbon unsaturation | 3 |
20080306300 | Stepwise Execution of Exothermic Reactions with Participation of Carbocations - The invention relates to a method for carrying out reactions with participation of carbocations, whereby the initial most strongly exothermic phase of the reaction is carried out at high temperature (60 to 120° C.) and short residence time (1 to 30 seconds) in a microreactor and the subsequent less exothermic phases are carried out at optionally lower temperatures in two or more residence time units with longer residence times (1 to 30 seconds). | 12-11-2008 |
20110263898 | ETHER-AMIDE COMPOUNDS AND PREPARATION AND USES THEREOF - Novel ether-amide compounds having the formula R | 10-27-2011 |
20140364648 | ETHER-AMIDE COMPOUNDS AND PREPARATION AND USES THEREOF - Ether-amide compounds having the formula R | 12-11-2014 |