Class / Patent application number | Description | Number of patent applications / Date published |
562465000 | Oxy | 53 |
20090005592 | HIGH SHEAR PROCESS FOR ASPIRIN PRODUCTION - Use of a high shear mechanical device in a process for production of acetyl salicylic acid, by contacting acetic anhydride with salicylic acid in a high shear device. The disclosed process makes possible a decrease in mass transfer limitations, thereby enhancing production of acetyl salicylic acid. A system for production of acetyl salicylic acid is also provided in which a reactor is configured to receive the output from a high shear device, which is configured to receive, via one or more inlets, acetic anhydride, and salicylic acid and generate a fine dispersion or emulsion of reactants. | 01-01-2009 |
20090221848 | PROCESS FOR PREPARING OCTENOIC ACID DERIVATIVES - The invention relates to a process for preparing chiral octenoic acid derivatives, which constitute important intermediates in the preparation of medicament active ingredients, and also to novel intermediates which are used in the process for preparing the octenoic acid derivatives mentioned. | 09-03-2009 |
20110275855 | SEPARATION OF AN ENANTIOMER MIXTURE OF (R)- AND (S)-3-AMINO-1-BUTANOL - The present invention relates to a process for separating an enantiomer mixture of (R)- and (S)-3-amino-1-butanol optionally protected on the oxygen atom, and to a process for preparing essentially enantiomerically pure (R)-3-amino-1-butanol which optionally bears a protecting group on the oxygen atom. | 11-10-2011 |
20120165567 | ONE POT MULTICOMPONENT SYNTHESIS OF SOME NOVEL HYDROXY STILBENE DERIVATIVES WITH ALPHA, BETA-CARBONYL CONJUGATION UNDER MICROWAVE IRRADIATION - The present invention provides a method for the preparation of some novel multiconjugated 2- or 4-hydroxy substituted stilbenes. The method provides one pot multicomponent approach wherein 3-4 step reaction sequences viz. condensation, decarboxylation and Heck coupling occur simultaneously which results in an enhanced yield of desired products and reduced reaction times | 06-28-2012 |
20150368138 | METHOD AND SYSTEM FOR THE INTEGRAL TREATMENT OF WASTEWATER FROM THE MAIZE INDUSTRY - A novel integral process for the treatment of wastewater, commonly known as nejayote, from the nixtamal, masa and tortilla industry, having an improved method for removing the insoluble fraction and a filtration system for separating and concentrating the fractions forming the nejayote. The method includes the steps of: (a) neutralizing the nejayote; (b) enzymatically hydrolysing the starch granules; (c) flocculating and separating the insoluble fraction. The system includes the steps of (a) microfiltration; (b) ultrafiltration for concentrating long-chain carbohydrates; (c) ultra/nano filtration for concentrating medium-size compounds; (d) nanofiltration/reverse osmosis for concentrating small molecules and obtaining water of sufficient quality that it can be re-used or safely discharged into the environment. In one embodiment of the invention, in order to remove unwanted phenolic compounds, the process includes a method including the steps of: (a) acidifying the effluents at pH<4; (b) flocculating and separating the unwanted insoluble fraction. | 12-24-2015 |
20160102047 | SUBSTITUTED N-PENTANAMIDE COMPOUNDS, PREPARATION METHOD AND THE USE THEREOF - The present invention relates to a (2R,3R)-3-(3-substituted phenyl)-2-methyl n-pentanamide compounds as shown in the formula I and the preparation method thereof, wherein, the substituents are as defined in the specification, the present invention further relates to a use of the above compounds for the preparation of tapentadol II or its pharmaceutically acceptable salt, and the intermediates involved in the preparation process | 04-14-2016 |
20160168076 | NOVEL PROCESS FOR THE PREPARATION OF LEVOTHYROXINE SODIUM | 06-16-2016 |
562466000 | Polycyclo ring system | 18 |
20120190888 | TREPROSTINIL PRODUCTION - The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil. | 07-26-2012 |
20120197041 | TREPROSTINIL PRODUCTION - The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil. | 08-02-2012 |
20120209026 | METHOD FOR PRODUCING A CARNOSIC ACID-RICH PLANT EXTRACT - A carnosic acid-rich plant extract can be produced by extracting a dried and comminuted plant material containing carnosic acid with supercritical CO | 08-16-2012 |
20120283470 | PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN.RTM. - This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil. | 11-08-2012 |
20130267734 | PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN.RTM. - This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil. | 10-10-2013 |
20130289304 | PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN.RTM. - This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil. | 10-31-2013 |
20130345471 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION - The compound according to Formula I is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a Formula I compound. | 12-26-2013 |
20140024856 | PROCESS FOR TREPROSTINIL SALT PREPARATION - Disclosed is a process for preparing a treprostinil salt. The process involves the step of dissolving treprostinil in a water-miscible organic solvent to form a treprostinil solution. The treprostinil solution is reacted with an aqueous basic solution containing an alkali metal cation to form treprostinil salt. Allowing crystallization of the treprostinil salt to take place, and then collecting the treprostinil salt formed. | 01-23-2014 |
20140275616 | SALTS OF TREPROSTINIL - Provided are novel treprostinil salts as well as methods for making treprostinil salts. | 09-18-2014 |
20150105582 | TREPROSTINIL PRODUCTION - The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil. | 04-16-2015 |
20150299091 | PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN.RTM. - This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil. | 10-22-2015 |
20160060205 | Method Of Preparing Fused Ring Indeno Compounds - The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride. With some embodiments, the fused ring indeno compound is represented by the following Formula (I-A), the dienophile is represented by the following Formula (II-A), and the lactone compound is represented by the following Formula (III-A): | 03-03-2016 |
562467000 | Carboxyl bonded directly to naphthylene ring system | 6 |
20090131713 | Process for the Preparation of Adapalene and Related Compounds - The invention provides an improved process for the preparation of a benzonaphthalene derivative including, in particular, the manufacture of high purity adapalene. The invention further includes a method for assessing the color of adapalene by means of a quantitative colorimetric measurement of the produced adapalene. | 05-21-2009 |
20090137841 | PROCESS FOR THE PREPARATION OF AROMATIC DERIVATIVES OF 1-ADAMANTANE - Process for the obtaining of 1-adamantane (tricycle[3.3.1.1 (3,7)]decane) derivatives, or of a pharmaceutically acceptable salt thereof, based on a carboxylation reaction, via metallation, of a precursor compound with an adequate leaving group. It also comprises the preparation of the precursor compound by means of a selective coupling of the corresponding boron, magnesium or zinc derivative with the corresponding disubstitute aromatic derivative. It is especially useful for the obtaining of Adapalene at industrial scale with good yield and high purity. | 05-28-2009 |
20100076219 | METHOD FOR PREPARATION OF 6-[3(1-ADAMANTYL) -4-METHOXYPHENYL]-2-NAPHTOIC ACID - A method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid is disclosed based on “one pot” synthesis approach including a direct synthesis of boronic acid derivative from 2-(1-adamantyl)-4-bromoanisole and cycloboranes with a subsequent Suzuki-Miyaura coupling with 6-halonaphthenoates and basic hydrolysis of the reaction product in ethylene glycol or 1,2-propanediol. | 03-25-2010 |
20100160677 | PROCESS FOR PREPARATION OF 6-[3-(1-ADMANTYL)-4-METHOXYPHENYL]-2-NAPHTOIC ACID. - A process for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid from 2-(1-adamantyl)-4-bromanisolee is disclosed, based on transformation of 2-(1-adamantyl)-4-bromanisole into a Grignard's reagent by using metallic magnesium, anhydrous lithium chloride and dibromoethane followed by transmetallation with borates to 3-(adamantyl)-4-methoxyphenylboronic acid, which is converted into 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid esters by Suzuki-Miyaura cross-coupling reaction with alkyl-6-halonaftoates catalyzed by Pd [0] or Pd/phosphine ligands and followed by basic hydrolysis in ethylene glycol or 1,2-propanediol of ester thus obtained into 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid. | 06-24-2010 |
20130030214 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS - The invention provides an improved process for the preparation of a benzonaphthalene derivative including, in particular, the manufacture of high purity adapalene. The invention further includes a method for assessing the color of adapalene by means of a quantitative colorimetric measurement of the produced adapalene. | 01-31-2013 |
20150141696 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS - The invention provides an improved process for the preparation of a benzonaphthalene derivative including, in particular, the manufacture of high purity adapalene. The invention further includes a method for assessing the color of adapalene by means of a quantitative colorimetric measurement of the produced adapalene. | 05-21-2015 |
562468000 | Plural rings bonded directly to the same carbon | 2 |
20100016633 | NOVEL BIS(FORMYLPHENYL)ALKANE AND NOVEL POLYNUCLEAR PHENOL DERIVED FROM THE SAME - Manufacture a novel bis(formylphenyl)alkane according to General Formula (1), as well as a novel polynuclear phenol derived therefrom, by causing a bis(hydroxymethyl-hydroxyphenyl)alkane to react with hexamethylene tetramine in the presence of an acid and hydrolyzing the reaction product, and then using the obtained bis(hydroxy-formylphenyl)alkane as a direct material and causing this material to react with halogenated alkoxycarbonyl hydrocarbon in the presence of a base. | 01-21-2010 |
20130184490 | PROCESS TO PREPARE S-2-HYDROXY-3-METHOXY-3,3-DIPHENYL PROPIONIC ACID - Disclosed is a process for the preparation of S-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid (I) the key intermediate for the preparation of Ambrisentan [(+)-2(S)-(4,6-Dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionic acid]. Ambrisentan of the formula (IA) is approved under the trademark “Letairis ®” by the US Food and Drug Administration for the treatment of Pulmonary artery hypertension (PAH). | 07-18-2013 |
562470000 | Oxy, not bonded directly to a ring, in same side chain as carboxyl, or salt thereof | 7 |
20080293965 | Process for the Dynamic Resolution of (Substituted) (R)- or (S)- Mandelic Acid - The present invention relates to a process for the resolution of mandelic acid derivative enantiomers from (racemic) mixtures by salt formation (see, for example, formula IIa) with chiral base cyclic amides, and racemisation of the unresolved enantiomer in the same process, wherein an additional racemising base may optionally be used, employing an acid:total base (i.e. cyclic amide and optional additional base) molar ratio of at least 1:1; provided that the cyclic amide base is present in a molar ratio of at least 0.75; and to the use of the resolved mandelic acid derivatives as intermediates suitable for large-scale manufacturing of, for example, pharmaceutical compounds; wherein R is selected from CHF | 11-27-2008 |
20090240079 | Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases - The present invention relates to a pharmaceutical composition useful for treating or preventing inflammatory disease and cell damage, and a method for treating or preventing inflammatory disease and cell damage. The present invention uses the 2-hydroxybenzoic acid derivative represented by the specific chemical formula or its pharmaceutically acceptable salt. The compound of the present invention is useful for treating or preventing cell damage and inflammatory disease including gastritis, gastric ulcer, pancreatitis, colitis, arthritis, diabetes, arteriosclerosis, nephritis, hepatitis, Alzheimer's disease, Parkinson's disease and Lou Gehrig's disease. | 09-24-2009 |
20100004483 | Novel Process For The Synthesis Of (E)-Stilbene Derivatives Which Makes It Possible To Obtain Resveratrol And Piceatannol - A subject-matter of the present invention is a novel process for the synthesis of (E)-stilbene derivatives targeted at obtaining in particular resveratrol and piceatannol. | 01-07-2010 |
20100185012 | METHOD FOR PRODUCING OPTICALLY ACTIVE TRANS-2-AMINOCYCLOHEXANOL AND INTERMEDIATE OF OPTICALLY ACTIVE TRANS-2-AMINOCYCLOHEXANOL - A method of producing optically active trans-2-aminocyclohexanol includes allowing racemic trans-2-aminocyclohexanol to react with optically active 2-methoxyphenylacetic acid to produce an optically active 2-methoxyphenylacetic acid salt of optically active trans-2-aminocyclohexanol and separating the salt. An optically active 2-methoxyphenylacetic acid salt of optically active trans-2-aminocyclohexanol is also provided. The method makes it possible to produce optically active trans-2-aminocyclohexanol with ease and a high yield from an industrially-advantageous, inexpensive raw material. | 07-22-2010 |
20110009664 | METHOD FOR PREPARING OPTIONALLY SUBSTITUTED P-HYDROXYMANDELIC COMPOUNDS AND DERIVATIVES THEREOF - The invention relates to a method for preparing optionally substituted P-hydroxymandelic compounds and derivatives thereof. The method for preparing the mandelic compounds of the invention comprises condensing in water, in the presence of an alkaline agent, an aromatic compound bearing at least one hydroxyl group and having a free para position, with glycoxylic acid, wherein said method is characterised in that said reaction is carried out in a piston-flow reactor. | 01-13-2011 |
20110124910 | CRYSTALLINE POTASSIUM SALT OF LIPOXIN A4 ANALOGS - This invention is directed to the crystalline potassium salt of a lipoxin A | 05-26-2011 |
20120116118 | Method for Producing (2,4-Dimethylbiphenyl-3-yl)Acetic Acids, the Esters Thereof and Intermediate Compounds - The present invention relates to a novel process for preparing substituted and unsubstituted (2,4-dimethylbiphenyl-3-yl)acetic acids and their esters of the formula (I) using homogeneous and heterogeneous palladium catalysts, and also the intermediates 4-tert-butyl-2,6-dimethylphenylacetic acid and 4-tert-butyl-2,6-dimethylmandelic acid, and to processes for their preparation. | 05-10-2012 |
562471000 | Oxy, bonded directly to a ring, in same side chain as carboxyl, or salt thereof | 4 |
20090082592 | GREEN CATALYTIC PROCESS FOR THE SYNTHESIS OF ACETYL SALICYLIC ACID - The present invention provides a green catalytic process for the synthesis of acetyl salicylic acid using solid acid catalysts at atmospheric pressure. The invention involve the solid acid catalyst such as sulfated transition metal oxides namely nano-crystalline sulfated zirconia, sulfated titania; modified zeolites namely zeolite H-beta, H—Y, H-ZSM-5 and K-10 montmorillonite clay in a solvent free environment using salicylic acid and acetic anhydride with yield about 95% and high selectivity (100%). The solid acid catalysts can be recovered, regenerated and reused. | 03-26-2009 |
20100210872 | Method for making hindered phenolic antioxidant - A method for making a hindered phenolic antioxidant based on Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate uses a methanol solution containing alkali metal methoxide as a catalyst solution, wherein the catalyst solution is filtered with a filter device with a filter pore diameter of less than 50 μm to remove insoluble matters therefrom before used in a transesterification process where methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate and 1-Octadecanol are taken as reactants to obtain a crude product of Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate having high conversion rate and low color, and the crude product further undergoes a purification process for crystallization, filtering and drying to obtain a product of Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate having high purity and low color. | 08-19-2010 |
20160185695 | METHOD FOR THE PREPARATION OF PHENOLS - The present invention relates to a method for the preparation of phenols, in which an aryldiazonium salt, which is prepared by the diazotisation of a corresponding aromatic, primary amine, is decomposed by heating in a mixture containing hot water, a mineral acid and an organic solvent, wherein the organic solvent contains a ketone of formula (I) R | 06-30-2016 |
562472000 | Halogen | 1 |
20080275270 | Process for Preparing Quaternary Acid and Ammonium Salts - A process for preparing a quaternary ammonium salt of a fibric acid, represented by the following reaction scheme: | 11-06-2008 |
562473000 | Carboxyl, or salt thereof, bonded directly to a ring | 14 |
20120178964 | Catalyst, Use Thereof and Process of Hydrogenating Aryl Aldehydes - This invention provides a catalyst and the use thereof and a process for hydrogenating carboxyaryl aldehydes with selectivity to hydroxyalkylaryl monocarboxylic acids. The catalyst comprises iridium. | 07-12-2012 |
20120197042 | PROCESS FOR PREPARING HIGHLY BRANCHED POLYHYDROXYBENZOIC ACID ALKOXYLATES - The invention relates to a process for preparing hyperbranched polyhydroxybenzoic acid alkoxylates, comprising the steps of:
| 08-02-2012 |
20130131378 | PROCESS FOR PREPARING 4-NITRO-OXY-METHYL-BENZOIC ACID - This invention relates to a new process for preparing 4-nitro-oxy-methyl-benzoic acid, comprising the following steps: a) reaction of 4-chloromethyl-benzoic acid with silver nitrate and in the presence of an acid as a catalyst in acetonitrile at reflux temperature, followed by cooling and adding of a polar aprotic solvent; b) separation of the silver salts by filtration, followed by washout with a polar aprotic solvent; c) precipitation of the 4-nitro-oxy-methyl-benzoic acid with water from the filtrate obtained in step b); and d) drying of the 4-nitro-oxy-methyl-benzoic acid. | 05-23-2013 |
20130204037 | Catalytic alkylation of alcohols to liquid ethers and organic compounds to alkylated products - A catalytic process is taught for non-oxidative alkylation of organic compounds, comprising alcohols, alkanes, glycols, ethers, aldehydes, ketones, carboxylic acids, esters, amines, thiols or phosphines, by alkyl groups produced from alcohols or glycols, forming products comprising ethers and other higher molecular weight alkylated compounds. The process is conducted at a reflux temperature below 200° C. in the presence of an acid, alkali or neutral salt dehydrating agent comprising sulfuric acid, phosphoric acid or their salts, lime or anhydrous calcium sulfate in the absence of zero valent metals and air. Specifically, this catalytic process converts ethanol to ethyl butyl ethers, ethyl hexyl ethers and dibutyl ethers or oxygenated gasoline as well as amines comprising n-butyl amine plus butanol to dibutyl amine and butyl hexyl amines at ambient pressure. This same catalytic alkylation chemistry, which does not constitute a condensation reaction, alkylates 4-hydroxybenzoic acid using ethanol to 4-ethoxyethylbenzoic acid products. | 08-08-2013 |
20140171680 | ANAEROBIC CONVERSION OF 4-CARBOXYBENZALDEHYDE IN IONIC LIQUIDS - A method of decreasing an amount of an aromatic aldehyde in a product is described. The method includes reacting the aromatic aldehyde in the presence of a reaction medium comprising a nucleophilic solvent, or an ionic liquid and a carboxylic acid, the reaction taking place in the absence of a hydrogenating agent and an oxidizing agent, to form aromatic carboxylic acid, an aromatic alcohol, or both. | 06-19-2014 |
20140235892 | PROCESS FOR THE PREPARATION OF A BENZENE DERIVATIVE - A substituted benzene derivative is prepared in a process, which includes
| 08-21-2014 |
20160068461 | SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION - The compound according to Formula I is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a Formula I compound. | 03-10-2016 |
562474000 | Halogen | 2 |
20090182168 | PROCESS FOR THE SELECTIVE DEPROTONATION AND FUNCTIONALIZATION OF 1-FLUORO-2-SUBSTITUTED-3-CHLOROBENZENES - 1-Fluoro-2-substituted-3-chlorobenzenes are selectively deprotonated and functionalized in the position adjacent to the fluoro substituent. | 07-16-2009 |
20130253222 | METHOD FOR PRODUCING 2-BROMO-4,5-DIALKOXY BENZOIC ACID - Provided is a method for effectively producing a 4,5-dialkoxy-2-hydroxybenzoic acid from an inexpensive raw material. | 09-26-2013 |
562475000 | Phenolic hydroxy or metallate | 5 |
20140081044 | Acetylene Bridged Linkers and Metal-Organic Frameworks (MOFs) Produced Thereof - Described are acetylene bridged linkers, metal-organic frameworks produced thereof, processes for producing the linkers and the metal-organic frameworks, and the use of the metal-organic frameworks. The metal-organic frameworks possess an enhanced ability to adsorb and desorb high amounts of gases, in particular methane or hydrogen. The metal-organic frameworks have a high porosity and, thus, a high inner surface. | 03-20-2014 |
20160009621 | CATALYSTS FOR THE MECHANOCATALYTIC OXIDATIVE DEPOLYMERIZATION OF POLYMER-CONTAINING MATERIALS AND METHODS OF MAKING OXIDIZED REACTION PRODUCTS USING SAME | 01-14-2016 |
562476000 | Poly phenolic hydroxy or metallate | 2 |
20110060161 | PROCESS FOR THE SYNTHESIS OF FLUORINATED ETHERS OF AROMATIC ACIDS - Fluorinated ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diketone ligand that coordinates to copper. The fluorinated ethers of aromatic acids made using the process described herein can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved. | 03-10-2011 |
20130046109 | INTEGRATED PROCESSES FOR THE PREPARATION OF POLYBENZIMIDAZOLE PRECURSORS - An integrated process is provided for efficiently preparing 2,4,5-triaminaphenol, starting with nitration of 2,6-dihalobenzene; high purity salts thereof; and complexes of 2,4,5-triaminophenol aromatic diacids, which are precursors for making polybenzimidazole polymer for high performance fibers. The process design eliminates several costly intermediate drying and recrystallization steps. The handling of solid materials with possible skin sensitizing properties and toxicity is avoided, thereby eliminating human and environmental exposure. | 02-21-2013 |
562477000 | Salicyclic acid per se or salt thereof | 1 |
20090012326 | Use of Salicylate as an Antidote for Paraquat Intoxications in Mammals - The present invention concerns to the use of salicylate in the treatment of mammal intoxications caused by the herbicide paraquat (PQ). It was achieved, for the first time, 100% of survival 30 days after the administration to Wistar rats, by intraperitoneal route, of a PQ dose that, in the absence of treatment, is itself 100% lethal at the end of 6 days. The administration of salicylate, two hours after PQ, reversed the PQ toxicity and extended the life of the animals to the levels of the control group. | 01-08-2009 |
562478000 | Phenolic hydroxy or metallate | 1 |
20110028758 | Trans-cinnamic acid derivative, its preparation mathod and the use - A compound of formula (I) or its pharmaceutically acceptable salt is prepared by ring opening of osthol under basic condition. The compound of formula (I) or its pharmaceutically acceptable salt has activity of selectively inhibiting tumor cells and lower toxicity, and can be used for preparing anti-tumor drugs. | 02-03-2011 |