Class / Patent application number | Description | Number of patent applications / Date published |
549399000 | Chalcogen bonded directly to the hetero ring | 79 |
20080275258 | Epigallocatechin Dimers or Trimers Having Lipase Inhibitory Activity and/or Antioxidant Activity - It is intended to provide a lipase activity inhibitor which shows a high inhibitory activity on pancreatic lipase, regulates the absorption of fat from meals and/or contributes to the regulation or prevention of obesity, a food and a drink containing the same, and a tea-origin lipase inhibitor being highly preferable and not worsening taste. It is also intended to provide a method of producing the lipase inhibitor. It is further intended to provide antioxidative agent. To overcome these problems, an epigallocatechin dimer (oolong homo bis flavans) or trimer is added to foods or drinks. Thus, the absorption of fat from meals can be regulated and an antioxidative effect can be obtained. The above compounds can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid. | 11-06-2008 |
20090005580 | Compounds, compositions and methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. | 01-01-2009 |
20090048457 | PROCESS FOR PREPARATION OF RACEMIC NEBIVOLOL - A process of making racemic [2S*[R*[R*[R*]]]] and [2R*[S*[S*[S*]]]]-(±)α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] of the compound of the formula (I) and its pure [2S*[R*[R*[R*]]]]- and [2R*[S*[S*[S*]]]]-enantiomer compounds and pharmaceutically acceptable salts thereof. | 02-19-2009 |
20090099373 | COMPOSITIONS ENRICHED IN ANTHOCYANINS - This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin. | 04-16-2009 |
20090099374 | METHOD FOR PRODUCING FLAVAN DERIVATIVE - The present invention provides a method for producing flavan derivatives having various substituent groups with controlling the stereochemistry. The method of the present invention includes the steps of: hydratively condensing a phenol compound expressed by formula (I) and an alcohol compound expressed by formula (II) to from an epoxide compound of formula (III); opening the epoxy ring of the epoxide compound of formula (III) to form an iodine-containing compound of formula (IV); and cyclizing the iodine-containing compound to form the flavan derivative of formula (V). | 04-16-2009 |
20090124818 | METHOD OF PRODUCING PROANTHOCYANIDIN-CONTAINING MATERIAL - The method for producing proanthocyanidin-containing product of the present invention comprises the steps of providing a pine bark as a starting material, extracting the pine bark with at least one of water and an organic solvent, and treating the resultant extract with a synthetic resin adsorbent, wherein the pine bark has characteristics in that at least 7 wt % of solid material in terms of dry weight is obtained from a pine bark extract that is obtained by adding 10 parts by volume of an aqueous ethanol solution containing ethanol in the range of 50 to 80 volume % to one part by weight of the pine bark, and performing extraction at 80 to 85° C. for one hour. It is possible to conveniently and efficiently obtain proanthocyanidin-containing product that contains at least 10 wt % of OPCs. | 05-14-2009 |
20090203926 | PROCESS FOR SELECTIVELY EXTRACTING PROCYANIDINS - A process is described for selectively extracting cocoa procyanidins from an aqueous mixture of cocoa polyphenols by using a particular sequence of solvents to extract selected procyanidin monomers and/or oligomers. The solvents are n-butyl acetate, ethyl acetate, methyl acetate, diethyl ether, or mixtures of methyl acetate and diethyl ether. Preferably, the aqueous mixture of cocoa polyphenols is first extracted with n-butyl acetate. The mixtures of methyl acetate and diethyl ether are between 25:75 and 75:25 (v/v). | 08-13-2009 |
20100048920 | Preparation of (+)-Catechin, (-)-Epicatechin, (-)-Catechin, and (+)-Epicatechin and Their 5,7,3',4'-Tetra-O-Benzyl Analogues - Processes for preparing racemic mixtures of 5,7,3′,4′-tetra-O-benzyl-(±)-catechin and (±)-epicatechin involves (i) condensing 2-hydroxy-4,6-bis(benzyloxy)-acetophenone and 3,4-bis(benzyloxy)benzaldehyde, cyclizing the resulting compound, oxidizing the resulting compound; (ii) dihydroxylating (E)-3-(3′,4′-bis(benzyloxy)phenyl)prop-2-ene-1-ol and reducing the 1,2-diol; or (iii) coupling 3,5-bis(benzyloxy)phenol with (E)-3,5-bis(benzyloxy)-2-(3′,4′-bis(benzyloxy)phenyl)allyl)phenol and cyclizing the resulting chalcone. | 02-25-2010 |
20100324312 | NOVEL METHYLATED CATECHIN AND COMPOSITION CONTAINING THE SAME - A novel methylated catechin is provided which has stronger antiallergic activity than conventionally known methylated catechins such as epigallocatechin-3-O-(3-O-methyl)gallate and epigallocatechin-3-O-(4-O-methyl)gallate. | 12-23-2010 |
20110124887 | EPIGALLOCATECHIN DIMERS OR TRIMERS HAVING LIPASE INHIBITORY ACTIVITY AND/OR ANTIOXIDANT ACTIVITY - An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the absorption of meal-derived fat and/or which contributes to suppressing and preventing obesity, as well as a food or beverage that has such lipase activity inhibitor incorporated therein. Another object of the invention is to provide a lipase inhibitor of tea origin that suits most consumers' taste and which will not impair the flavor of the food or beverage when incorporated therein. Still another object of the invention is to provide a process for producing said lipase inhibitors. Further object of the invention is to provide antioxidants. To attain these objects, epigallocatechin dimers (oolong homobisflavans) or trimers are incorporated in foods or beverages. As a result, the absorption of meal-derived fat can be suppressed and, in addition, antioxidation effect is obtained. The compounds of the invention can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid. | 05-26-2011 |
20110160467 | Method for the Preparation of C-4 Coupled Flavonoids, Proanthocyanidins and Analogues Thereof - The invention relates to a novel process for the preparation of C-4 coupled flavonoids, proanthocyanidins and analogues thereof. According to a specific application of the invention, there is provided a method for the preparation of proanthocyanidins and proanthocyanidin analogues. | 06-30-2011 |
20110201831 | PROCESS FOR PREPARING NEBIVOLOL - The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent. | 08-18-2011 |
20120065410 | ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING - The object of the present invention is to provide an anti-obesity agent which contains a tea-derived component and which is safe and does not compromise the flavor of foods and beverages. | 03-15-2012 |
20120088923 | METHOD FOR PREPARING A COUMARIN COMPOUND, CHROMENE COMPOUND, AND METHOD FOR PREPARING A CHROMENE COMPOUND - Disclosed herein is a method for preparing a coumarin compound of formula (F), in which R | 04-12-2012 |
20120142947 | Stabilized 3-Hydroxyflavan Compositions and Methods Therefor - Compositions and methods are directed to covalent adducts between reducing agents and optionally substituted 3-hydroxyflavans, wherein the reducing agent is covalently bound to the B-ring of the 3-hydroxyflavan. Such adducts exhibit markedly increased stability towards oxidation as compared to the unmodified 3-hydroxyflavan. Particularly preferred 3-hydroxyflavans include green tea catechins, and especially EGCG, while especially preferred reducing agents include NAC and glutathione. | 06-07-2012 |
20120309991 | METHODS FOR EXTRACTING COCOA PROCYANIDINS AND EXTRACTS THEREOF - A cocoa extract which is rich in procyanidin monomers and oligomers is made by extracting de-fatted, unroasted, unfermented cocoa beans with organic solvents. The yield of procyanidins in an extract varies with type of solvent used, reaction temperature, reaction pH and whether or not the solvent is an aqueous solution. Extraction parameters can be optimized to increase procyanidin yield, and different conditions result in the preferential extraction of the higher or lower oligomers. A preferred extraction method is counter-current extraction method. | 12-06-2012 |
20130079532 | PROCESS FOR THE PREPARATION OF 2-HYDROXY-4-PHENYL-3,4-DIHYDRO-2H-CHROMEN-6-YL-METHANOL AND (R)-FESO-DEACYL - The present invention regards an improved and industrially advantageous process for the preparation of the 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol intermediates, also called “feso chromenyl” and (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol, also called “(R)-feso deacyl”, which are in turn used in the synthesis of fesoterodine and in particular of fesoterodine fumarate. This process utilises reagents which are non-toxic and manageable at industrial level and enables obtaining a new stable and non-hygroscopic crystalline form of the key intermediate “(R)-feso deacyl”, called form B. | 03-28-2013 |
20140121388 | ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING - The object of the present invention is to provide an anti-obesity agent which contains a tea-derived component and which is safe and does not compromise the flavor of foods and beverages. | 05-01-2014 |
20140213802 | (-)-Epigallocatechin Gallate Derivatives for Inhibiting Proteasome - A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula: | 07-31-2014 |
20140309439 | METHOD FOR EXTRACTING ANTHOCYANIN DERIVATIVES FROM A PLANT SOURCE - The present document describes a method for extracting anthocyanin derivatives from a plant source. The method comprises the step of separating a homogenized extract of plant source in a polar acidified solvent for obtaining a residual solid, and a filtrate mixed with the acidified polar solvent. The separation includes a coarse filtration done by centrifugation of the plant source extract, by a filtration with a first filter having a pore size of about 100 μm, and a fine filtration is done using a second filter having a pore size of about 10 μm. Then, the filtrate mixed with the acidified polar solvent is evaporated for substantially separating the acidified polar solvent from the filtrate to obtain a semi-solid extract of anthocyanin derivatives. | 10-16-2014 |
20140343303 | NOVEL EPIGALLOCATECHIN GALLATE TETRAMER AND VASCULAR ENDOTHELIAL FUNCTION IMPROVING AGENT CONTAINING THE SAME - Providing a compound capable of continuously taking and having a vascular endothelial function improving effect by enhancing NO function from the vascular endothelial cells. | 11-20-2014 |
20140371471 | CHEMICAL ENHANCEMENT BY NANOMATERIALS UNDER X-RAY IRRADIATION - A method for dynamic enhancement of chemical reactions by nanomaterials under hard X-ray irradiation. The nanomaterials were gold and platinum nanoparticles, and the chemical reaction employed was the hydroxylation of coumarin carboxylic acid. The reaction yield was enhanced 2000 times over that predicted on the basis of the absorption of X-rays only by the nanoparticles, and the enhancement was found for the first time to depend on the X-ray dose rate. The maximum turnover frequency was measured at 116×10-4 s-1 Gy-1. We call this process chemical enhancement, which is defined as the increased yield of a chemical reaction due to the chemical properties of the added materials. The chemical enhancement described here is believed to be ubiquitous and may significantly alter the outcome of chemical reactions under X-ray irradiation with the assistance of nanomaterials. | 12-18-2014 |
20150133681 | METHODS OF PURIFYING AND IDENTIFYING THE PRESENCE OF AND LEVELS OF PROCYANIDIN OLIGOMERIC COMPOUNDS - The invention provides methods of purifying and quantifying procyanidin oligomers from cocoa-containing sources. The methods advantageously provide ways to isolate commercially useful quantities of a range of procyanidin oligomers. | 05-14-2015 |
20160068503 | (-)-EPIGALLOCATECHIN GALLATE DERIVATIVES FOR INHIBITING PROTEASOME - A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula: | 03-10-2016 |
20160185742 | Method for Preparing Benzopyran Compound and Application thereof in Treating Pulmonary Fibrosis - The present invention opens to the public a method to prepare a benzopyran compound and its use for treating pulmonary fibrosis. A benzopyran compound has a structure (I): | 06-30-2016 |
20190144412 | Selenium-enriched tea polyphenol selenide preparation | 05-16-2019 |
549400000 | Plural chalcogens bonded directly to the hetero ring | 11 |
20080214844 | Icaritin and desmethylicaritin as anti-cancer agents - The antiproliferative effects of Icaritin or Desmethylicaritin on cancer cell lines, both in vitro, and in vivo, are disclosed. Experimental data show that Icaritin and Desmethylicaritin dramatically inhibit the growth of most malignant cells. In addition, both Icaritin and Desmethylicaritin have significant Anti-agiogenesis properties, inhibiting or eliminating entirely the development of new malignant cells. Further, no obvious side effects including nausea, hair loss or body weight loss were found in the animals treated with Icaritin or Desmethylicaritin, making both highly effective anti cancer drugs. | 09-04-2008 |
20090088580 | Method for Stabilizing Quercetin - This invention relates to a method for stabilizing quercetin by placing it in a solution containing vitamin B3 and vitamin C and assessing stability of the quercetin in the mixture. | 04-02-2009 |
20110021792 | SULFUR-CONTAINING PROANTHOCYANIDIN OLIGOMER COMPOSITION AND PRODUCTION METHOD THEREOF - Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging. | 01-27-2011 |
20110028742 | SULFUR-CONTAINING PROANTHOCYANIDIN OLIGOMER COMPOSITION AND PRODUCTION METHOD THEREOF - Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging. | 02-03-2011 |
20110190514 | PYRONE ANALOG COMPOSITIONS AND METHODS - Novel pyrone analogs are described which can enhance the effectiveness of a therapeutic agent when administered and/or reduce side effects caused by the administration of a therapeutic agent. | 08-04-2011 |
20130237712 | METHOD FOR ISOLATING FLAVONOID DIHYDROQUERCETIN (TAXIFOLIN) FROM CONIFER WOOD SPECIES - A method for isolating flavonoid Dihydroquercetin (taxifolin) from wood parts including lower portions of the trunk, referred to as butt logs, bark and roots. The method includes extracting either the particle-reduced chip fraction obtained by chipping or subdividing into chips the butt logs and roots, or dry cork fraction of the bark or powdered bark obtained as a residue in finishing of mechanical wood products with a polar solvent. The method further includes recovering the extract. The wood used in the method is a hardwood or a coniferous wood selected from wood of | 09-12-2013 |
20130281717 | METHOD FOR PRODUCING DIHYDROQUERCETIN - The invention relates to the chemical and pharmaceutical industry. The essence of the invention consists in that the bark is removed from Siberian or Dahurian larch wood, the wood is chopped and dried at 40-50° C. to a residual humidity of 15-25 percent. The dried wood is ground, and the soluble substances are extracted from the sawdust using a 75 percent aqueous solution of ethyl alcohol at a temperature of 40-50° C. with a ratio of raw material to extraction agent of 1:(6-7). The extraction agent is then distilled off, and the aqueous portion of the extract is cooled to 38-42° C. over a period of 20-30 minutes for the removal (sedimentation) of the heavy resinous impurities accompanying the DHQ. The resin-free aqueous DHQ extract is fed into a chromatographic column filled with the hydrophobic polyvinyl benzene-based sorbent LPS 500. The desired product is eluted with a 32-40 percent solution of ethyl alcohol. The eluate is collected in a single portion or is divided into two or three fractions, depending upon the required purity of the product obtained (DHQ). Each fraction is evaporated until the ethyl alcohol is completely removed, and the residue is crystallized from deionized water. The desired product is obtained with a purity level of 95.5-99.5 percent and a yield of 1.5-2.5 percent of the mass of absolutely dry wood. The technical effect includes simplifying the method, increasing its ecological compatibility and reducing its duration, while increasing the purity of the product obtained to 99.5 percent. | 10-24-2013 |
20140323745 | Polyphenolic selenium compound having functional group of alkali metal ion and selenium complex - A polyphenolic selenium compound having a functional group of alkali metal ion and selenium complex which has an aromatic ring is provided, wherein the aromatic ring comprises at least two functional groups, each of which is one member selected from the group consisting of oxygen functional group, sulphur functional group, phosphorus functional group and nitrogen functional group; and selenium complex functional group is formed by selenium, alkali metal ion and the functional group. The polyphenolic selenium compound having a functional group of alkali metal ion and selenium complex of the present invention has characteristics of over 20% selenium content and no toxicity. Because it has revolutionary effects in killing bacteria, virus and cancer cell, enhancing human immunity, removing oxygen free radicals and etc., it holds a vital medicinal value. | 10-30-2014 |
20140357876 | USE OF ICARITIN FOR THE PREPARATION OF COMPOSITION FOR TREATING CANCER - The present invention provides the use of Icaritin for the preparation of a composition for treating cancer, wherein the composition is orally administered to a patient at least one cycle, each cycle comprising a continuous 28-day dosing schedule, in which Icaritin is administered at least once daily, at a dosage of 400-1800 mg daily. The patients treated with Icaritin according to the present method receive better treatment, with reduced adverse effects. | 12-04-2014 |
20150080587 | PROCESS FOR THE MANUFACTURE OF TAXIFOLIN FROM WOOD - The invention relates to a process for the manufacture of taxifolin, comprising the following steps: stacking the wood particles in a percolator, extracting the wood particles in the percolator using ethanol to dissolve at least resins, oils, and taxifolin, discharging the ethanolic extract from the percolator, and purifying the ethanolic extract for the manufacture of taxifolin with the following steps in the specified order: preparing a mixture of water and the ethanolic extract, mixing the mixture at between 70° C. and 99° C. so that taxifolin in the aqueous phase of the mixture goes into the solution, cooling the mixture to below 65° C. for separating and removing the resin phase and the oil phase from the water phase, adding taxifolin seed crystals to the water phase, temperature controlling the water phase at between 0° C. and 30° C. for the crystallisation of taxifolin, and separating the crystallised taxifolin from the mother liquor. | 03-19-2015 |
20160251329 | FLUOROPHORE 3-HYDROXYFLAVONE | 09-01-2016 |
549401000 | Chalcogen bonded directly to the ring carbon para to the ring oxygen (e.g., chromones, etc.) | 42 |
20100076206 | PROCESS FOR PREPARING NEBIVOLOL - The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula, wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol. | 03-25-2010 |
20110009646 | RUTHENIUM-DIAMINE COMPLEX AND METHODS FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS - There are provided a novel ruthenium-diamine complex, and methods for selectively producing an optically active alcohol and an optically active amine, which are important as precursors for the synthesis of medicinal drugs and functional materials, using the ruthenium-diamine complex as a catalyst. | 01-13-2011 |
20110213166 | FLUORINATED 4-OXO-CHROMAN-7-CARBOXYLATES - The present invention is directed to compositions comprising fluorinated 4-oxo-chroman-carboxylates, particularly fluorinated 4-oxo-chroman-7-carboxylate, and a process for making the same. The compounds are useful as intermediates in the production of agricultural chemicals, and also as chain terminators in condensation polymerization reactions, particularly when it is desired to provide a polymer having a relatively low surface energy. | 09-01-2011 |
20110282077 | PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL - The object of the present invention is to solve the problems in the prior arts, and to find more improved reaction conditions for suppressing the racemization of the product and obtaining an optically active alcohol at a high optical purity. The inventors achieved to solve the above problems by using a solvent system that is capable of resolving both an asymmetric catalyst and a formate salt, allowing the hydrogen source and the asymmetric catalyst to be present in the same phase. | 11-17-2011 |
20120209012 | COMPOUNDS, COMPOSITIONS AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. | 08-16-2012 |
20130158276 | RUTHENIUM-DIAMINE COMPLEXES AND METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS - Provided is a catalyst for asymmetric reduction, which can be produced by a convenient and safe production method, has a strong catalytic activity, and has excellent stereoselectivity. The present invention relates to a ruthenium complex represented by the following formula (1): wherein R | 06-20-2013 |
20140051871 | RUTHENIUM-DIAMINE COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND - Provided is a ruthenium complex that is represented by general formula (1*) and is useful as an asymmetric reduction catalyst. | 02-20-2014 |
20160067696 | RUTHENIUM-DIAMINE COMPLEXES AND METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS - Provided is a catalyst for asymmetric reduction, which can be produced by a convenient and safe production method, has a strong catalytic activity, and has excellent stereoselectivity. The present invention relates to a ruthenium complex represented by the following formula (1): wherein R | 03-10-2016 |
20160145228 | FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES IN THE PRESENCE OF UREAS OR THIOUREAS - The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one urea or thiourea. | 05-26-2016 |
20160152588 | FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES | 06-02-2016 |
20160168110 | FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES IN THE PRESENCE OF ACIDS | 06-16-2016 |
20160168111 | FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES IN THE PRESENCE OF PHENOLS OR THIOPHENOLS | 06-16-2016 |
549402000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to the hetero ring | 3 |
20090264664 | PREPARATION FOR EXTERNAL APPLICATION COMPRISING SALT OF MAST CELL DEGRANULATION INHIBITOR HAVING CARBOXYL GROUP WITH ORGANIC AMINE - Mast cell degranulation inhibitors having a carboxyl group have not been developed as external preparations due to the low transdermal permeability thereof. By formulating external preparations thereof, side effects on the internal organs by oral administration can be avoided. Some of the mast cell degranulation inhibitors show drastically inferior photostability, which is also one cause of suppressed development of the drug as an external preparation. | 10-22-2009 |
20100094026 | METHOD OF SCREENING COMPOUND USEFUL IN TREATING ALLERGIC DISEASE - The present invention provides a method of screening for a compound useful for treatment of an allergic disease by identifying a molecule targeted by Intal upon exertion of its efficacy as an anti-allergic agent (hereinafter referred as a target) and using the target, as well as a new type of anti-allergic agent comprising a compound obtainable by the screening as an active ingredient for treatment of an allergic disease. | 04-15-2010 |
20150353519 | THERAPEUTIC AGENT FOR DISEASE BASED ON INHIBITORY EFFECT OF MACROPHAGE MIGRATION INHIBITORY FACTOR - A benzopyran derivative represented by general formula [1], or a salt thereof, is useful in therapeutic or preventive treatment of disease, wherein said therapeutic or preventive treatment is effective because said benzopyran derivative, or salt thereof, binds to MIF, has an MIF inhibitory effect, and inhibits MIF. | 12-10-2015 |
549403000 | Benzene ring bonded directly to the hetero ring (e.g., flavones, etc.) | 27 |
20080306286 | Isolation, Purification and Synthesis of Procyanidin B2 and Uses Thereof - Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin B2 in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus | 12-11-2008 |
20090062555 | Synthesis of Isoflavone - The invention provides a process of manufacturing an isoflavone of the general formula 7 | 03-05-2009 |
20090259055 | Catalytic enantioselective synthesis of flavanones and chromanones - Various chromanone, flavanone and abyssinone compounds as can be prepared enantioselectively using a chiral thiourea catalyst. | 10-15-2009 |
20090287001 | Process for the Manufacture of Hydroxylated Isoflavones - A process for the preparation of hydroxylated isoflavones by reacting in a Hoesch reaction using an alkanoic acid alkyl ester as solvent a phenol with a phenylacetonitrile to yield a 1,2-diphenyl-ethanone and transforming the ethanone into an isoflavone by well-known methods. | 11-19-2009 |
20100048921 | PHARMACEUTICALLY ACTIVE COMPOUNDS - This invention relates to pharmaceutically active compounds consisting of an isoflavone or isoflavone-glycoside and an amino acid, a peptide or peptide derivate with 2 to 5 amino acids which is covalently bonded to these, as well as pharmaceutically acceptable salts or solvates of these compositions as well as to the use of those substances for the production of pharmaceutical compositions, in particular for the treatment of thrombocyte aggregation and tumor therapy. | 02-25-2010 |
20100056812 | COMPOSITION FOR TREATING CANCER CELLS AND PREPARATION METHOD FOR THE SAME - A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells. | 03-04-2010 |
20100081832 | COMPOSITION FOR TREATING CANCER CELLS AND PREPARATION METHOD FOR THE SAME - A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells. | 04-01-2010 |
20100121082 | PROCESS FOR PREPARING 2,4-DIHYDROXYPHENYL 4-METHOXYBENZYL KETONES - The invention relates to a process for preparing 2,4-dihydroxyphenyl 4-methoxybenzyl ketones of the formula (I) by Friedel-Crafts acylation in hydrogen fluoride (HF). | 05-13-2010 |
20100121083 | ANTI-VIRAL AGENT - Provided is an antiviral agent with high antiviral activities and low side effects (cytotoxicity). Specifically provided is an antiviral agent comprising as an effective component at least one member selected from the group consisting of 5,7,4′-trihydroxy-3′,5′-dimethoxyflavone, 3-hydroxypyridine, p-hydroxybenzaldehyde and vanillin. | 05-13-2010 |
20100191003 | METHOD FOR PRODUCING GLYCOSIDE AGLYCONE - It is intended to provide a method for producing aglycone from a glycoside efficiently at low cost without using an acid catalyst or an organic solvent. The method for producing aglycone, characterized by bringing a glycoside into contact with high temperature high pressure water. The temperature of the high temperature high pressure water is generally from 100 to 374° C., preferably from 140 to 320° C., more preferably from 200 to 300° C. The pressure of the high temperature high pressure water may be not lower than the saturated water vapor pressure at the temperature, i.e., a pressure at which the liquid state is maintained. | 07-29-2010 |
20100261916 | METHOD FOR RESOLUTION OF A MIXTURE OF PINOCEMBRIN OPTICAL ISOMERS, ESPECIALLY A PINOCEMBRIN RACEMATE - The present invention relates to a method for resolution of a mixture of pinocembrin optical isomers, in particular a pinocembrin racemate, using a chiral primary amine or a chiral sulfinamide. The present invention also relates to a (R)-(+)-pinocembrin obtained by the method. | 10-14-2010 |
20110015411 | INHIBITOR FOR GROWTH OF BACTERIA OF GENUS LEGIONELLA, BATH AGENT AND CLEANING AGENT - A growth inhibitor of bacteria of the genus | 01-20-2011 |
20110190515 | SUBSTITUTED 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES, PREPARATION AND USES THEREOF - The invention concerns novel substituted 1,3-diphenylprop-2-en-1-one derivatives, pharmaceutical compositions comprising same, their therapeutic uses, in particular for treating cerebral ischemia. The invention also concerns a method for preparing said derivatives. | 08-04-2011 |
20120059176 | ANTI-INFLAMMATORY MODALITIES - Anti-inflammatory modalities are described with reference to select isoflavonoid compounds, compositions containing same and the use of said compounds and/or compositions in treatment, particularly for the treatment of inflammatory diseases and related conditions. | 03-08-2012 |
20120165558 | REGULARLY STACKED MULTILAMELLAR AND RANDOMLY ALIGNED UNILAMELLAR ZEOLITE NANOSHEETS, AND THEIR ANALOGUE MATERIALS WHOSE FRAMEWORK THICKNESS WERE CORRESPONDING TO ONE UNIT CELL SIZE OR LESS THAN 10 UNIT CELL SIZE - The present invention relates to microporous molecular sieve materials and their analogue molecular sieve materials having a crystalline unilamellar or multilamellar framework with a single unit cell thickness in which layers are aligned regularly or randomly, the molecular sieve materials being synthesized by adding an organic surfactant to the synthesis composition of zeolite. In addition, the present invention relates to micro-mesoporous molecular sieve materials activated or functionalized by dealumination, ion exchange or other post treatments, and the use thereof as catalyst. These novel materials have dramatically increased external surface area by virtue of their framework with nano-scale thickness, and thus exhibit improved molecular diffusion, and thus have much higher activities as catalyst and ion exchange resin than conventional zeolites. In particular, the materials of the present invention exhibit high reactivity and dramatically increased catalyst life in various organic reactions such as carbon-carbon coupling, alkylation, acylation, etc. of organic molecules. | 06-28-2012 |
20120289715 | Synthesis of C-3 Coupled Biflavonoids and C-3 Coupled Biflavonoid Analogues - The invention relates to methods for the preparation of an optically inactive and optically active compounds which are selected from the group consisting of C-3 coupled biflavonoids and C-3 coupled biflavonoid analogues from a starting material or intermediate which are respectively selected from the group consisting of optically inactive or optically active flavan-3-ols and optically active flavan-3-ones, the method comprising the steps of (a) providing an optically inactive or active compound having a flavan-3-ol structure or a compound which is a flavan-3-one, (b) if a compound having a flavan-3-ol structure with a hydroxy group on the C-3 carbon is selected as starting material, converting the hydroxy group on the C-3 carbon of the compound having the flavan-3-ol structure to an oxo group to form a flavan-3-one of that compound, (c) providing a compound having a nucleophilic aromatic moiety, which compound is selected from the group of compounds having a nucleophilic aromatic moiety and which have flavonoid base structures and compounds having a nucleophilic aromatic moiety and which do not have a flavonoid base structure, (d) contacting the flavan-3-one provided by step (a) or obtained by step (b) with the compound containing the nucleophilic aromatic moiety in the presence of a Lewis acid; (e) forming a first intermediate compound wherein the oxo group on the C-3 carbon is converted to a hydroxy group by virtue of nucleophilic addition when the compound containing the nucleophilic aromatic moiety is contacted to the C-3 carbon of the flavan-3-one, (f) subjecting the first intermediate compound to dehydration so as to introduce a double bond between the C-3 carbon and C-4 carbon of the intermediate compound with the concomitant removal of the hydroxy group from the C-3 carbon to form an optically active flavene compound which is substituted by the nucleophilic aromatic moiety on the C-3 carbon, (g) optionally subjecting the resultant flavene compound to hydroboration-oxidation hydration thereby removing said double bond between the C-3 carbon and the C-4 carbon with the concomitant introduction of a hydroxy group at the C-4 carbon to form a second intermediate compound, (h) further optionally oxidizing the second intermediate compound of step (g) thereby converting the hydroxy group at the said C-4 carbon to an oxo group, thereby forming a biflavonoid or biflavonoid analogue which is substituted by the selected nucleophilic aromatic moiety on the C-3 carbon, (i) further optionally, and alternatively to step (h), subjecting the resultant flavene compound of step (f) to OsO | 11-15-2012 |
20120289716 | METHOD FOR HIGH-SPEED FLUOROMETHYLATION AND PROCESS FOR PREPARATION OF PET TRACER USING SAME - Provided are: a method for rapid fluoromethylation, by which a fluoromethyl group can be easily bonded to an aromatic-ring carbon of an aromatic compound with little generation of by-products; and a process for preparation of a PET tracer using the same. The method is characterized by cross-coupling an organoboron compound in which an aromatic ring is bonded to a boron atom with FCX | 11-15-2012 |
20130116450 | METHOD FOR ENANTIOSELECTIVE HYDROGENATION OF CHROMENES - A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A preferred Ir catalyst has a chiral phosphineoxazoline ligand. Enantiomeric chromanes of high stereoselective purity can be obtained. | 05-09-2013 |
20130231492 | FLAVONE DERIVATIVES AND THEIR PREPARATIVE METHOD AND MEDICAL USE - Flavone derivatives, preparative method of the derivatives and use thereof as medicaments for treating diabetes. The structure of the derivatives is presented by formula 1: In the structure, R | 09-05-2013 |
20130296582 | INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS - The present invention provides compounds and methods of inhibiting and treating metastatic prostate cancer. The compounds include MEK4 inhibitors. In another aspect the invention provides methods of identifying inhibitors of metastatic prostate cancer by screening for inhibitors of MEK4. | 11-07-2013 |
20140031567 | Method of Converting Fustin to Fisetin - The present invention relates to a method for converting fustin into fisetin through the gas bubbling treatment of a solution containing fustin. | 01-30-2014 |
20140296543 | PRENYLFLAVANONE COMPOUNDS FOR MODULATING DIABETES - The present invention is directed to a novel use of prenylflavanone compounds for control of blood glucose and treatment or prevention of diabetes. | 10-02-2014 |
20150148551 | GENISTEIN FOR REDUCING LEVELS OF STORAGE COMPOUNDS IN THE TREATMENT AND/OR PREVENTION OF LYSOSOMAL STORAGE DISEASES (LSDS) - The subject of the invention is genistein for use in non-enzymatic method of treatment and/or prevention of the lysosomal storage diseases (LSDs) i.e. diseases with the underlying defect in degradation and resulting accumulation of organic compounds in lysosomes, to reduce the level of storage of organic compounds by reducing the rate of efficiency of accumulating organic substances synthesis and/or by increasing the rate of efficiency of cellular deposits degradation. | 05-28-2015 |
20160074358 | PPAR alpha/gamma Dual Agonist and Its Application - The present invention discloses a PPAR α/γ dual agonist and its application. The PPAR α/γ dual agonist comprises an effective amount of the compounds represented by formula I or/and its pharmaceutically acceptable derivative. Wherein. R | 03-17-2016 |
20160096815 | T-TYPE CALCIUM CHANNEL INHIBITOR - The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this compound or a solvate of this compound. The present invention also provides: this T-type calcium channel inhibitor; a pharmaceutical product containing this T-type calcium channel inhibitor; and a therapeutic agent or prophylactic agent for diseases, the effective action of which is a T-type calcium channel inhibitory action. (In formula (1), each of R | 04-07-2016 |
20160137623 | METHOD FOR SEPARATING FLAVONOID SUBSTANCES IN CAMELLIA NITIDISSIMA CHI BASED ON A MAGNETIC NANOPARTICLES-PAMAM NANO COMPOSITES - The present invention discloses a method for separating flavonoid substances in | 05-19-2016 |
20160145229 | EXTRACTION SEPARATION METHOD OF A FLAVONE COMPONENT BASED ON GRAPHENE - The present invention refers to the technical field of flavone component extraction, and provides an extraction separation method of a flavone component based on amination graphene. The flavone components comprise flavones, flavanols, isoflavones, flavanones, flavanonols, flavanones, anthocyanidins, chalcones, and chromones etc. The extraction separation method is adsorption extraction, and amination graphene is taken as a medium of adsorption extraction. The extraction separation method of the flavone components based on amination graphene is superior in separation speed and product purity, low cost and convenient operation. | 05-26-2016 |