Class / Patent application number | Description | Number of patent applications / Date published |
548405000 | Boron containing | 27 |
20080300413 | Methods of Preparing Hetercyclic Boronic Acids and Derivatives Thereof - In the context of synthesizing heterocyclic boronic acid compounds, a convergent synthetic methodology is particularly efficient for preparing boropyrrolidines and derivatives of boropyrrolidines. | 12-04-2008 |
20090054663 | COUPLING PROCESS FOR GENERATING REACTIVE BORON-CONTAINING DERIVATIVES OF N-SUBSTITUTED PYRROLE-2-CARBONITRILES TO PRODUCE BIARYLS - A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds. | 02-26-2009 |
20090105487 | CONJUGATED COMPOUNDS CONTAINING HETEROATOM-CENTER-ARYLSILANE DERIVATIVES AND THEIR APPLICATION - The present invention discloses conjugated compounds containing heteroatom-centered arylsilane derivatives and their applications as host materials, electron transport materials, or hole transport materials in an organic electroluminescent device. The general structure of the conjugated compounds containing heteroatom-centered arylsilane derivatives is as follows: | 04-23-2009 |
20090203923 | Boron-dipyrrin compounds comprising thienyl groups, preparation method thereof and chemosensor comprising the same - Disclosed are (i) a boron-dipyrrin compound having thienyl groups, (ii) a preparation method thereof and (iii) a chemosensor comprising the boron-dipyrrin compound having thienyl groups. More particularly, the present invention provides a boron-dipyrrin compound having thienyl group, furyl (OC4H3) group or selyl (SeC4H3) group, which is represented by the following formula (1), a preparation method thereof and a chemosensor comprising the above boron-dipyrrin compound having thienyl groups, characterized in that the chemosensor exhibits variations in colors and fluorescent properties caused by reaction of the boron-dipyrrin compound with metal ions, including, but not limited to, Cu | 08-13-2009 |
20090318707 | NOVEL MALEIMIDE DERIVATIVE - A compound represented by the following general formula (I): | 12-24-2009 |
20100036133 | NOVEL ZWITTERIONIC DYES FOR LABELING IN PROTEOMIC AND OTHER BIOLOGICAL ANALYSES - The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics. | 02-11-2010 |
20100036134 | Subphthalocyanine derivative having phosphorus derivative as axially substituted group, method for manufacturing the same and optical film using the same - A novel subphthalocyanine derivative having a phosphorus derivative-substituted group as an axially substituted group which has an excellent solubility, a method for producing the same and an optical film containing the same, are provided without impairing excellent properties peculiar to the original subphthalocyanines. The novel subphthalocyanine derivative is represented by the following chemical formula (1), and it is applicable for optical films. | 02-11-2010 |
20100076201 | Carbazole Derivative and Method for Producing the Same - To provide a method for producing a wide variety of carbazole derivatives which have a simple and uncomplicated process and in which variations in the yield, purity, etc. of a desired substance which are caused by an aryl group introduced is reduced as much as possible. A method for producing a carbazole derivative represented by General Formula (1) is provided, in which 9-[4-(10-phenyl-9-anthryl)phenyl]-9H-carbazole having an active site at the 3-position of the carbazole skeleton and an aromatic compound having an active site are coupled. | 03-25-2010 |
20100087658 | METHODS AND INTERMEDIATES FOR SYNTHESIS OF SELECTIVE DPP-IV INHIBITORS - Methods and intermediates for the synthesis of selective inhibitors of dipeptidyl peptidase IV (DPP-IV) are provided. Coupling of a carboxylate salt with a boro-proline derivative provides a protected form of a DPP-IV inhibitor, which may be deblocked to yield the medicinal compound. The carboxylate salt can be a crystalline form of a sodium salt or a dicyclohexylammonium salt. The inhibitor can be used in the treatment of diabetes. | 04-08-2010 |
20100204484 | CRYSTALLINE SYNTHETIC INTERMEDIATE FOR PREPARATION OF A DPP-IV INHIBITOR AND METHOD OF PURIFICATION THEREOF - The invention provides a crystalline form of a synthetic intermediate useful in the preparation of a DPP-IV inhibitor, a method for preparing the crystalline form of the intermediate, and a method of using the crystalline form of the intermediate in the preparation of the inhibitor. | 08-12-2010 |
20110015407 | METHOD FOR THE PREPARATION OF ATORVASTATIN AND INTERMEDIATES USED THEREIN - The present invention relates to a novel method for preparing atorvastatin. According to the present invention, provided are a novel intermediate of the preparation of atorvastatin and a method of preparing large amounts of atorvastatin in a safe manner using the intermediate. | 01-20-2011 |
20110054187 | DIFLUOROBORADIAZAINDACENE DYES - The invention relates to difluoroboradiazaindacene dyes of the formula (1) | 03-03-2011 |
20110207941 | SYNTHESIS OF AMINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF - The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, | 08-25-2011 |
20120220782 | SYNTHESIS OF AMINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF - The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, | 08-30-2012 |
20120245362 | SYNTHESIS OF BORON DIPYRROMETHENES WITH LASER PROPERTIES - A family of three 8-alkyl boron dipyrromethenes 1, 2, and 3 has been prepared. These compounds are characterized by emission in the green region of the electromagnetic radiation spectrum and exhibit an almost double laser efficiency than other commercial dyes and much greater photostability. The 8-alkyl boron dipyrromethenes are prepared by catalytic hydrogenation (reduction) of the corresponding 8-alkenyl boron dipyrromethenes, which are obtained by Liebeskind-Srogl coupling of thiomethylboron dipyrromethene with an alkenyl boronic acid. | 09-27-2012 |
20120253050 | SYNTHESIS OF 8-AMINO BORON DIPYRROMETHENES HAVING BLUE FLUORESCENCE - A family of six 8-amino boron dipyrromethenes having Formulas 1, 2, 3, 4, 6, and 7 has been prepared. The presence of the amine group alters the emission properties of the boron dipyrromethene, such that these compounds are characterized by unexpected blue fluorescence, providing for potential use as lasers. The compound having formula 1 has very high quantum yield. The 8-amino boron dipyrromethenes are prepared in a straightforward, high yield synthesis by substituting an amine group for the thiomethyl group at the 8 position in 8-thiomethyl boron dipyrromethene. The compounds having Formulas 6 and 7 may be used to incorporate peptides and proteins, thus providing biomolecules marked with fluorescent fragments. | 10-04-2012 |
20140018545 | Inhibitors of Dipeptidylpeptidase IV - The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. In particular, the inhibitors of the present invention are improved over those in the prior art by selection of particular classes of sidechains in the P1 and/or P2 position of the inhibitor that contain a carboxylic acid moiety. The compounds of the present invention can have a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease. | 01-16-2014 |
20140051863 | FLUORESCENT PROBES FOR DETECTION OF COPPER - The invention provides fluorescent sensors for the selective detection of a metal such as copper. The sensors may be considered to be derivatives of cyanine, fluorescein, rhodamine, rhodol, Tokyo green, or BODIPY. The sensors find particular use in detecting copper in cells and living animals. | 02-20-2014 |
20140058115 | Boron Dipyrromethenes With Laser Properties - A family of three 8-alkyl boron dipyrromethenes 1, 2, and 3 has been prepared. These compounds are characterized by emission in the green region of the electromagnetic radiation spectrum and exhibit an almost double laser efficiency than other commercial dyes and much greater photostability. The 8-alkyl boron dipyrromethenes are prepared by catalytic hydrogenation (reduction) of the corresponding 8-alkenyl boron dipyrromethenes, which are obtained by | 02-27-2014 |
20140094615 | Automated Synthesis of Small Molecules Using Chiral, Non-Racemic Boronates - Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification. | 04-03-2014 |
20140187791 | Carbazole Derivative and Method for Producing the Same - To provide a method for producing a wide variety of carbazole derivatives which have a simple and uncomplicated process and in which variations in the yield, purity, etc. of a desired substance which are caused by an aryl group introduced is reduced as much as possible. A method for producing a carbazole derivative represented by General Formula (1) is provided, in which 9-[4-(10-phenyl-9-anthryl)phenyl]-9H-carbazole having an active site at the 3-position of the carbazole skeleton and an aromatic compound having an active site are coupled. | 07-03-2014 |
20150031896 | COMPOUNDS FOR ORGANIC ELECTRONIC DEVICES - The present invention relates to the improvement of organic electroluminescent devices, in particular blue-emitting devices, by using compounds of the formula (1) as dopants in the emitting layer. | 01-29-2015 |
20150065729 | BORON SUBPHTHALOCYANINE COMPOUNDS AND METHOD OF MAKING - A compound comprising a boron subphthalocyanine moiety, a plurality of solubilizing substituents positioned on peripheral cyclic groups of the boron subphthalocyanine moiety and an axial substituent positioned on the boron atom of the boron subphthalocyanine moiety. The plurality of solubilizing substituents comprise an oxygen or sulfur containing functional group and a substituted or unsubstituted, linear, branched or cyclic, aliphatic or aromatic terminal hydrocarbyl group that is 8 or more carbon atoms in length, the hydrocarbyl group optionally containing one or more heteroatoms. The axial substituent is selected from the group consisting of halogen, alkyloxy, haloalkyloxy, ester, carbonyl substituted alkyl, carbonyl substituted haloalkyl, alkylaryloxy, haloalkylaryloxy, alkyl sulfonyl, haloalkyl sulfonyl, alkylaryl sulfonyl and haloalkylaryl sulfonyl. The compound is not one of the following compounds: a) Phenoxytrispentadecylphenoxyboronsubphthalocyanine, b) Chlorotrispentadecylphenoxyboronsubphthalocyanine, or c) 3-Pentadecylphenoxytrispentadecylphenoxyboronsubphthalocyanine. Processes for making the compound are also taught. | 03-05-2015 |
20150105562 | METHOD FOR PREPARING BORINIC ACID DERIVATIVES AND NOVEL BORINIC ACID DERIVATIVES - The present invention relates to a method for preparing borinic acid derivatives and novel borinic acid derivatives. The preparing method of the present invention provides borinic acid derivatives of general formula (2): | 04-16-2015 |
20150141660 | Substrates and Inhibitors of Antiplasmin Cleaving Enzyme and Fibroblast Activation Protein and Methods of Use - The presently disclosed and claimed inventive concepts include inhibitors of antiplasmin cleaving enzyme (APCE) and fibroblast activation protein alpha (FAP) which can be used in various therapies related to disorders of fibrin and α | 05-21-2015 |
20150329567 | Automated Synthesis of Small Molecules Using Chiral, Non-Racemic Boronates - Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification. | 11-19-2015 |
20160002270 | SYNTHESIS AND USE OF FLUORINATED COMPOUNDS - The invention is directed to the preparation of fluorinated compounds and their use in organic synthesis. In particular, the invention is directed to methods of reacting compounds of structure with R | 01-07-2016 |