Class / Patent application number | Description | Number of patent applications / Date published |
548200000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to the thiazole ring | 21 |
20080293950 | Production Process of Compound Having Anti-Hcv Action and Intermediate Thereof - A method whereby a compound having HCV replication inhibitory activity and desired optical activity can be synthesized selectively and at high yield in a small number of steps by using a compound having a specific chiral auxiliary as a starting compound is provided. | 11-27-2008 |
20100204482 | HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS MICROBIOCIDES - The invention relates to a fungicidally active compound of formula (I): | 08-12-2010 |
20100240903 | CRYSTALLINE TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS - The invention relates to crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. | 09-23-2010 |
20130090479 | THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES - The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions. | 04-11-2013 |
548201000 | The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens | 17 |
20090030210 | Process for Producing Optically Active 2-Alkylcysteine, Derivative Thereof, and Processes for Production - There is provided a process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by allowing cells of microorganism or treated products thereof having an activity of stereoselective hydrolysis of the amide bond of a 2-alkyl-L-cysteinamide or a salt thereof to act on a 2-alkylcysteinamide consisting of a mixture of D- and L-isomers or a salt thereof; and allowing the obtained 2-alkyl-L-cysteine and 2-alkyl-D-cysteinamide to react with an aldehyde or a ketone, or an acetal or ketal thereof, so as to derive therefrom a 4-alkylthiazolidine-4-carboxylic acid or a salt thereof and a 4-alkylthiazolidine-4-carboxamide or a salt thereof, thereby efficiently separating and obtaining a 2-alkyl-L-cysteine or a salt thereof, or a 2-alkyl-D-cysteine or a salt thereof. There is also provided a process for producing a 4-alkylthiazolidine-4-carboxylic acid or a salt thereof from the 2-alkylcysteine or a salt thereof. | 01-29-2009 |
20090203919 | METHOD FOR PRODUCING CRYSTAL POLYMORPHS OF 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLECARBOXYLIC ACID - A method for producing crystal A of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid by dissolving 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in methanol or a mixed solvent of methanol and water (the volume ratio of methanol to water is 90/10 or more), then adding water until the ratio of methanol to water becomes 7/3, and further adding a specific amount of a seed crystal at a specific timing during the addition of water. | 08-13-2009 |
20110184185 | Methods Of Preparing Thiazolidines - The present invention provides methods of preparing thiazolidines, and in particular methods of preparing ribose-cysteine. | 07-28-2011 |
20110282069 | HIGH-PURITY FEBUXOSTAT AND THE METHOD FOR PREPARATION - A febuxostat which purity is not less than 99.0%, method for preparation thereof, and pharmaceutical composition thereof. The method for preparation includes recrystallizing febuxostat in a mixed solvent. The said pharmaceutical composition can be used in manufacture of medicaments for treating diseases associated with hyperuricemia. | 11-17-2011 |
20110313169 | PROCESS FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE THROUGH COUPLING USING TRANSITION METAL CATALYST - A process for efficiently producing, through few steps either a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or an intermediate therefore. The process is a novel coupling process which comprises subjecting a compound represented by formula (1) to coupling reaction with a compound represented by formula (2) in the presence of a transition metal compound to thereby obtain a compound represented by formula (3). | 12-22-2011 |
20120108821 | PROCESS FOR PRODUCING CRYSTALS OF POLYMORPHIC 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLECABOXYLIC ACID BY POOR-SOLVENT ADDITION METHOD - Disclosed is a process for producing A-form crystals of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected from the group consisting of 1-propanol, 2-propanol, ethanol, and acetone; a step of cooling the solution; and a step of adding to the solution a hydrocarbon solvent as a poor solvent. | 05-03-2012 |
20130123507 | BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF - The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description. | 05-16-2013 |
20130158272 | METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING PALLADIUM COMPOUND - The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C | 06-20-2013 |
20130165662 | PREPARATION OF FEBUXOSTAT - Processes for preparing febuxostat. | 06-27-2013 |
20130172571 | PROCESS TO PREPARE ETHYL 4-METHYL-2-(4-(2-METHYLPROPYLOXY)-3-CYANOPHENYL)-5-THIAZOLECARBOXYLATE - Disclosed is a process for the preparation of Ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate (I) the key intermediate for the preparation of [2-[3-cyano-4-(2-Methyl-propoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (Febuxostat, I(A)) is approved under the trademark Uloric® by the US Food and Drug Administration for the treatment of hyperuricemia and gouty arthritis. | 07-04-2013 |
20130184466 | PROCESS FOR PREPARING THE CRYSTALLINE FORM II OF FEBUXOSTAT - The present invention relates to a novel process for preparing the crystalline form II of febuxostat by crystallization of a solvent selected from ethyl acetate, methyl acetate or ethyl formiate. | 07-18-2013 |
20130225830 | POLYMORPHS OF FEBUXOSTAT - The present invention provides new crystalline forms of febuxostat, pharmaceutical compositions comprising same, methods for their preparation and use thereof in treating hyperuricaemia. | 08-29-2013 |
20130245278 | PROCESS FOR THE PREPARATION OF FEBUXOSTAT - An improved and efficient process for the preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat) that is substantially free from amide by-product is provided. | 09-19-2013 |
20130303780 | PROCESS FOR THE PREPARATION OF 2-ARYLTHIAZOLE DERIVATIVES - The present invention relates an improved process for the preparation of 2-arylthiazole derivatives which are intermediates of Febuxostat and further conversion to Febuxostat or pharmaceutically acceptable salts thereof. | 11-14-2013 |
20140249318 | THERAPEUTIC AGENT AND PREVENTIVE AGENT FOR DEMYELINATING DISEASE - The object of the present invention is to provide a novel therapeutic or preventive agent for demyelinating disease. The present invention is a therapeutic or preventive agent for demyelinating disease, containing as an active ingredient a 2-phenylthiazole compound represented by Formula (I) | 09-04-2014 |
20150141658 | PREPARATION OF FEBUXOSTAT - Processes for preparing febuxostat. | 05-21-2015 |
20160058740 | USE OF PIDOTIMOD TO TREAT IRRITABLE BOWEL SYNDROME - The present invention is directed to the use of pidotimod, or a physiologically acceptable salt thereof, to treat irritable bowel syndrome. For the treatment of the present invention, pidotimod, or a physiologically acceptable salt thereof, may be administered either by oral route or rectally. | 03-03-2016 |