Class / Patent application number | Description | Number of patent applications / Date published |
540203000 |
Polycyclo ring system containing the hetero ring as one of the cyclos
| 70 |
540354000 |
Additional chalcogen bonded directly to the hetero ring
| 6 |
540362000 |
The 4-position of the hetero ring is unsubstituted or alkyl substituted only | 3 |
20080287674 | Inhibitors of Factor XA and Other Serine Proteases Involved in the Coagulation Cascade - Compounds useful as intermediates for synthesis of compounds of Formula (I): | 11-20-2008 |
20110015389 | 1,3 IMIDAZOLIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF CARBAPENEM - Preparation of new heterocyclic compounds characterised by 1,3-imidazolidine structure useful for stereoselective synthesis of optically pure key intermediates in 1β-methylcarbapenem production | 01-20-2011 |
20130035482 | BISPHOSPHONATE COMPOUNDS - Novel bisphosphonate cyclic acetal compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating bone metabolism disorders, such as abnormal calcium and phosphate metabolism. | 02-07-2013 |
540202000 |
Plural hetero atoms in the hetero ring | 2 |
20110301345 | METHOD FOR PRODUCING 1:1 ADDUCTS HAVING A LOW MONOMER CONTENT FROM HYDROXYALKYL(METH)ACRYLATES AND DIISOCYANATES - The present invention relates to the production and the use of 1:1 adducts having a low monomer content from hydroxyalkyl(meth)acrylates and diisocyanates. | 12-08-2011 |
20130012698 | METHOD TO PRODUCE URETONIMINE-MODIFIED ISOCYANATE COMPOSITION - A method to produce uretonimine-modified isocyanate composition comprises
| 01-10-2013 |
540201000 |
Heavy metal containing | 1 |
20160168071 | PHOSPHORAMIDITE DERIVATIVES IN THE HYDROFORMYLATION OF UNSATURATED COMPOUNDS | 06-16-2016 |
540364000 |
Nitrogen bonded directly at the 3-position of the hetero ring | 1 |
20120220765 | BETA-LACTAMYL PHENYLALANINE, CYSTEINE, AND SERINE VASOPRESSIN ANTAGONISTS - Substituted 2-(azetidin-2-on-1-yl)alkoxyalkylalkanoic acids and 2-(azetidin-2-on-1-yl)arylalkylalkanoic acids, and analogs and derivatives thereof are described. Methods for using the described compounds, and pharmaceutical compositions thereof, to treat disease states responsive to antagonism of one or more vasopressin receptors are also described. | 08-30-2012 |
Entries |
Document | Title | Date |
20080200669 | Processes For Production of Phenolic 4-Biphenylylazetidin-2-Ones - The present invention relates to processes for the production of phenolic 4-biphenylylazetidin-2-one derivatives of formula | 08-21-2008 |
20080227974 | Novel Substituted Azetidinones - Novel azetidinones and pharmaceutical compositions are described, as are the methods of using such compounds and compositions to treat subjects, including humans, suffering from hyperlipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis. | 09-18-2008 |
20080281092 | Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use - Compounds of the formula I, | 11-13-2008 |
20090030195 | 1-(2H)-ISOQUINOLONE DERIVATIVE - The present invention provides a compound having high antitumor activity, which is useful for therapeutic and preventive agents effective for proliferative diseases such as cancer; a production method thereof; an intermediate compound useful for such production; and a pharmaceutical composition comprising such a compound. The present invention provides a compound represented by the formula (1): | 01-29-2009 |
20090048441 | Process for the Preparation of Ezetimibe - The present invention relates to a cost effective and industrially advantageous process for the preparation of (3R,4S)-1-(4-Fluorophenyl)-3-[3(S)-3-(4-fluorophenyl)-3-hydroxypropyl)]-4-(4-hydroxyphenyl)-2-azetidinone, referred to here as Ezetimibe, it is represented as formula (1). | 02-19-2009 |
20090062527 | Process for Preparing Optically Active Alcohols - This invention relates to a process for producing optically active alcohols using asymmetric reduction of aromatic ketones. This process gives optically active alcohols in high enantioselectivity at large scale production. Aromatic ketones represented by formula (I) | 03-05-2009 |
20090093627 | Process for preparing intermediates of ezetimibe by microbial reduction - Processes of preparing an ezetimibe intermediate by microbial reduction and further converting the intermediate to ezetimibe are provided. Also provided is an ezetimibe intermediate with high diastereomeric excess. | 04-09-2009 |
20090099355 | Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids - The present invention relates to processes for the production of 4-(biphenylyl)azetidin-2-one phosphonic acid derivatives of formula | 04-16-2009 |
20090216009 | PROCESS FOR THE PRODUCTION OF EZETIMIBE AND INTERMEDIATES USED IN THIS PROCESS - An industrially easily realizable and economical process comprising only few steps, and built on new intermediates for the production of 1-(4-3(R)-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) according to the reaction scheme described herein. | 08-27-2009 |
20090247743 | PREPARATION OF BETA-AMINO ACIDS HAVING AFFINITY FOR THE ALPHA-2-DELTA PROTEIN - Disclosed are materials and methods for preparing optically active β-amino acids of Formula 1, | 10-01-2009 |
20100010212 | Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophen- yl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe - The invention encompasses (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-2-azetidinone (Compound 2a) having an enantiomeric purity of at least about 97.5%. The invention also encompasses Compound 2a having a chemical purity of at least about 97%. The invention further encompasses processes for preparing Compound 2a from Compound 1 having the following formula: | 01-14-2010 |
20100168414 | PROCESSES FOR PREPARING EZETIMIBE AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION THEREOF - The invention relates, in general, to an improved process for converting compounds of Formula II (below) to compounds of Formula III (below), which are key intermediates for the synthesis of ezetimibe, or to ezetimibe itself, wherein in Formulas II and III, R represents hydrogen, alkyl, or a hydroxyl protecting group (e.g., benzyl group, a substituted benzyl group, or a silyl group). The invention further includes the use of the described process and the use of compounds of Formula III made by the described process for the preparation of ezetimibe. | 07-01-2010 |
20100298556 | Method for crystallization of azetidinonecarboxylic acid - The present invention relates to a method for crystallization of (2R)-2-{(3S, 4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-oxoazetidin-4-yl}propionic acid, and is characterized in that crystallization is carried out by mixing a solution containing the compound with a substituted aromatic hydrocarbon solvent and/or a halogenated hydrocarbon solvent. The method can provide a crystal of the compound with a high purity and a high yield while the content of 2S isomer is kept at a low level. | 11-25-2010 |
20110009617 | Ruthenium Catalysts and Uses Thereof - Ruthenium nanoparticles supported on non-cross-linked soluble polystyrene were prepared by reacting [RuCl | 01-13-2011 |
20110144326 | Method for manufacturing stereoselective preparation of 4-BMA using a chiral auxiliary and chiral auxiliary - The present invention relates to a process for preparing (3R,4S)-3-[[[R]-1′-t-butyldimethylsilyloxy]ethyl]-4-[(R)-1″-carboxyethyl]-2-azetidinone (beta-methylazetidin-2-one; 4-BMA), a key intermediate for the synthesis of carbapenem and penem antibiotics. Specifically, the present invention relates to a process comprising first, the preparation of a chiral auxiliary from cheap L-Phenylalaninol, and then the preparation of 4-BMA in high yield and high selectivity, under industrially mild condition. | 06-16-2011 |
20110144327 | PROCESS FOR THE SYNTHESIS OF AZETIDINONES - A process is provided for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, comprising reacting a β-(substituted-amino)amide, a β-(substituted-amino)acid ester, or a β-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride, wherein a quaternary ammonium moiety of the cyclizing agent is unsubstituted or substituted by one to four groups independently selected from the group consisting of alkyl, arylalkyl and arylalkyl-alkyl. | 06-16-2011 |
20120022248 | B-LACTAM COMPOUNDS - Novel methods for the production of enantiomerically pure (EP) β-lactams by decomposition of α-diazo-β-ketoamides. | 01-26-2012 |
20120029185 | NOVEL INTERMEDIATES IN THE PREPARATION OF 1,4-DIPHENYL AZETIDINONE - The process of the present invention relates to a method for the synthesis of a 1,4-diphenylazetidinone of formula (VIII) by using novel oxime intermediates. | 02-02-2012 |
20120083601 | PROCESS FOR THE SYNTHESIS OF AZETIDINONES - A process is provided for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, comprising reacting a β-(substituted-amino)amide, a β-(substituted-amino)acid ester, or a β-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride, wherein a quaternary ammonium moiety of the cyclizing agent is unsubstituted or substituted by one to four groups independently selected from the group consisting of alkyl, arylalkyl and arylalkyl-alkyl. | 04-05-2012 |
20120184731 | Method for synthesizing beta lactam compounds by decomposition of an alpha-diazo-beta-ketoamide using a fluorescent light source - Novel methods for the production of enantiomerically pure (EP) β-lactams by decomposition of α-diazo-β-ketoamides using fluorescent light. | 07-19-2012 |
20120208994 | AZETIDINONE COMPOUNDS AND MEDICAL USE THEREOF - Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R | 08-16-2012 |
20130190487 | PROCESS FOR THE PREPARATION OF EZETIMIBE AND DERIVATIVES THEREOF - The present invention relates to the method of preparing of ezetimibe and in particular to novel intermediates for its synthesis and an improved process for preparing such intermediates. Said intermediates may be obtained in high yields and purity in a fast and cost efficient manner. The present invention relates to a novel crystalline form of ezetimibe as well. | 07-25-2013 |
20150148533 | New Synthetic Route For The Preparation Of Beta-aminobutyryl Substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]Pyrazin-7-yl Compounds - The present invention relates to a process for preparing □-aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-α]pyrazin-7-yl compounds. | 05-28-2015 |
20160083402 | ORGANOBORON COMPOUNDS AND METHODS OF MAKING ORGANOBORON COMPOUNDS - Embodiments of the present disclosure provide for methods of making an organoboron compound, organoboron compounds, and the like. | 03-24-2016 |