Class / Patent application number | Description | Number of patent applications / Date published |
530323000 | Peptides with at least one nonpeptide bond other than a disulfide bond joining two or more sequences of amino acid residues, e.g., homomeric heterodectic peptide other than cyclic disulfide, depsipeptides, etc. | 38 |
20080221303 | Method for the Preparation of Peptide-Oligonucleotide Conjugates - The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks. | 09-11-2008 |
20080234464 | Compound Having Amino Acid Residue or Peptide Residue and Process for Producing the Same - An object of the present invention is to provide a compound with a structure wherein amino acid or oligopeptide side chains are bonded to a main chain. | 09-25-2008 |
20090118467 | Macromolecular Compounds Having Controlled Stoichiometry - The following invention is directed to macromolecules having controlled stoichiometry and topology, processes for their production, and applications for their use. The macromolecules have a controlled functional moiety stoichiometry and include at least one dendritic motif having a surface layer formed from at least one surface building unit and at least one subsurface layer formed from at least one building unit, the surface building unit and building units having a hydrocarbon backbone bearing a carbonyl group and at least one amine group; and at least two different functional moieties on the building unit and/or surface building unit; where functional moiety stoichiometry refers to the number and type of functional moieties. | 05-07-2009 |
20090275730 | Temperature responsive depsipeptide polymer - There is provided a temperature responsive polymer compound which comprises a repeating unit represented by the following general formula (I): | 11-05-2009 |
20100099843 | DOLASTATIN 15 DERIVATIVES - Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, | 04-22-2010 |
20100145006 | SUPRAVALENT COMPOUNDS - Supravalent peptide compounds depicting enhanced efficacy, and which comprise at least bivalent peptide units that bind to a receptor target and are connected to a polymeric carrier unit are disclosed herein. | 06-10-2010 |
20100234563 | Methods for Preparing Internally Constrained Peptides and Peptidomimetics - The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 3 | 09-16-2010 |
20110166321 | DOUBLE-ACYLATED GLP-1 DERIVATIVES - The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1(7-37) (SEQ ID NO: 1), a second K residue at a position corresponding to position 26 of GLP-1(7-37), and a maximum of ten amino acid modifications as compared to GLP-1(7-37), wherein the first K residue is designated K | 07-07-2011 |
20110237776 | AROMATIC COMPOUNDS WITH SULFUR CONTAINING LIGANDS - Compounds useful as nutritional supplements, antioxidants, heavy metal chelators and/or as intermediates for producing other related compounds with like uses have a formula: | 09-29-2011 |
20110282029 | NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR - The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided. | 11-17-2011 |
20120029167 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND - A drug using the magnetic properties of a metal salen complex as represented by the following general formula in order to magnetize the intended drug by chemically binding the drug to a metal salen complex so that the drug can be delivered to the target diseased site. The drug can be delivered to the diseased site using the magnetic properties of the drug per se without using a carrier made of a magnetic substance as in the conventional methods. | 02-02-2012 |
20120046442 | ROMIDEPSIN SOLID FORMS AND USES THEREOF - The present disclosure provides solid forms of a compound of formula I. In some embodiments, the present disclosure provides crystalline forms of Compound I. In some embodiments, the present disclosure provides solvate forms of Compound I. In some embodiments, the present disclosure provides amorphous Compound I. | 02-23-2012 |
20120065369 | LONG LASTING FUSION PEPTIDE INHIBITORS FOR HIV INFECTION - This invention relates to enfuvirtide peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to enfuvirtide derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections. | 03-15-2012 |
20120077957 | Lactam-Bridged Melanocortin Receptor-Specific Peptides - Lactam-bridged melanocortin receptor-specific cyclic peptides of the formula | 03-29-2012 |
20120116051 | Polymer Conjugate Of Bioactive Substance Having Hydroxy Group - A polymer conjugate of a physiologically active substance, which enables drug release independent of a biological enzyme and can be expected to have a high therapeutic effect, is demanded. | 05-10-2012 |
20120157658 | METHODS, COMPOSITIONS, AND APPARATUSES FOR FORMING MACROCYCLIC COMPOUNDS - This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired reaction pathway that includes at least cyclization, and which are further capable of forming undesired oligomers through a undesired reaction pathway that includes undesirable oligomerization. Oligomerization of such reactions in the reaction medium is modulated to reduce formation of undesired oligomers and/or to reduce separation of the undesired oligomers from the reaction medium, relative to a corresponding unmodulated oligomerization reaction, thereby maximizing yields of the macrocyclic compound. The macrocyclic compound so formed is then recovered from the reaction medium. Preferably, the macrocyclic compound spontaneously separates from the reaction medium via phase separation. More preferably, the macrocyclic compound spontaneous precipitates from the reaction medium and therefore can be easily recovered by simple filtration. | 06-21-2012 |
20120190818 | TRIAZOLE MACROCYCLE SYSTEMS - The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production. | 07-26-2012 |
20120253008 | PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME - The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs. | 10-04-2012 |
20120277406 | Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates - The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, | 11-01-2012 |
20130023644 | BETA-AMINO ACIDS - Disclosed are β-amino acid monomers containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the α and β carbons of the peptide backbone and β-polypeptides made from such monomers. Method of generating combinatorial libraries of polypeptides containing the β-peptide residues and libraries formed thereby are disclosed. | 01-24-2013 |
20130144035 | COMPOSITIONS AND METHODS FOR LEUKOCYTE-TARGETING MULTI-VALENT IMAGING PROBES - The present application discloses a new multivalent peptide ligand specifically targeting polymorphonuclear leukocytes (PMNs) with favorable pharmacological parameters to monitor sites of inflammation for imaging. The detailed synthesis, characterization, and pharmacological evaluation of the ligands are reported here. Two separate peptide binding ligands for formyl peptide and tuftsin receptors were chosen to link together based on the high expression levels of the two receptors on activated PMNs The heterobivalency and pegylated links were incorporated in the structural design to improve the sensitivity of the detection and to improve the bioavailability along with blood clearance profile, respectively. Two chemical constructs: cFLFLF-(PEG) | 06-06-2013 |
20130158232 | METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND - The disclosure relates to the field of candidate drug testing and drug development. Described are methods for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule able to react with the at least first and second reactive group; and contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage. The coupling reaction may be performed in solution, such as an aqueous solution. Furthermore, described is a method for selecting a candidate drug compound comprising providing a library of the compounds and determining the binding of a target molecule to the compounds. | 06-20-2013 |
20130197190 | METHOD FOR PRODUCING SURFACTIN AND SALT THEREOF - The method for producing a surfactin or a salt thereof according to the present invention comprises the steps of adding an organic solvent containing a branched alkyl alcohol to a culture fluid containing the surfactin or the salt thereof, or to a solution obtained by removing an insoluble component from the culture fluid, and extracting the surfactin or the salt thereof with the organic solvent, | 08-01-2013 |
20140005355 | PROCESS FOR PREPARATION OF CASPOFUNGIN ACETATE AND INTERMEDIATES | 01-02-2014 |
20140080995 | Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates - The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, | 03-20-2014 |
20140100355 | Solution Phase Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates - The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula I, | 04-10-2014 |
20140135473 | BIS-SULFHYDRYL MACROCYCLIZATION SYSTEMS - The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production. | 05-15-2014 |
20140296478 | METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND - The disclosure relates to the field of candidate drug testing and drug development. Described are methods for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule able to react with the at least first and second reactive group; and contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage. The coupling reaction may be performed in solution, such as an aqueous solution. Furthermore, described is a method for selecting a candidate drug compound comprising providing a library of the compounds and determining the binding of a target molecule to the compounds. | 10-02-2014 |
20150073121 | NOVEL CROSS-LINKED PEPTIDES CONTAINING NON-PEPTIDE CROSS-LINKED STRUCTURE, METHOD FOR SYNTHESIZING CROSS-LINKED PEPTIDES, AND NOVEL ORGANIC COMPOUND USED IN METHOD - The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link. | 03-12-2015 |
20150126707 | DAPTOMYCIN ANALOGUES AND A METHOD FOR THE PREPARATION OF DAPTOMYCIN OR A DAPTOMYCIN ANALOGUE - A method for the synthesis of daptomycin or a daptomycin analogue is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogues can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues. Daptomycin analogues can include a different fatty acid in the side arm of the daptomycin analogue. | 05-07-2015 |
20150141615 | ALDEHYDE ACETAL BASED PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES - The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I employing an aldehyde acetal intermediate, | 05-21-2015 |
20150361110 | SUPER LEWIS ACIDIC BORATE ESTERS AS 18F-LABELED PET PROBES - Compounds having a 1-bora-1-fluoro-2,6,7-trioxabicyclo[2.2.2]octane moiety wherein the fluorine is | 12-17-2015 |
20160015823 | PEPTIDE-DENDRIMER CONJUGATES AND USES THEREOF - The invention relates to dendrimers conjugated to multiple targeting peptides and one or more therapeutic, diagnostic, or imaging agents for delivery of such agents across the blood-brain barrier and into certain cell types including, cells expressing the LRP-1 receptor. Also described are methods of making compounds that comprise dendrimers conjugated to targeting peptides and therapeutic, diagnostic, or imaging agents. | 01-21-2016 |
20160031936 | TRIAZOLE MACROCYCLE SYSTEMS - The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production. | 02-04-2016 |
20160046673 | MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITY - The invention describes peptide ligands specific for human plasma Kallikrein. | 02-18-2016 |
20160060294 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF - Antiproliferative compounds having a structure represented by formula (II), where n, R | 03-03-2016 |
20160130300 | INHIBITORS OF HEPATITIS C VIRUS - Compounds of Formula I are disclosed | 05-12-2016 |
20160194357 | Novel NPR-B Agonists | 07-07-2016 |