Class / Patent application number | Description | Number of patent applications / Date published |
514464000 | Bicyclo ring system having the hetero ring as one of the cyclos (e.g., methylenedioxyphenyl group, etc.) | 66 |
20080214661 | Process To Obtain Dibenzylbutyrolactonic, Tetrahydrofuranic Lignans And Their Synthetic And Semi-Synthetic Derivatives, Their Analgesic And Anti-Inflammatory Activities, Topical And/Or Systemic Formulations Containing Said Lignans And Their Respective Therapeutic Method - A process to obtain dibenzylbutyrolactonic lignans from (-)-cubebin, isolated from a | 09-04-2008 |
20080275110 | Sesamin/Episesamin Compositions - Sesamin and episesamin are incorporated at specified weight ratios in oral compositions so that the oral absorption of episesamin and/or its transfer into blood circulation is increased. Sesamin and episesamin are also incorporated at specified weight ratios in oral compositions so that the physiological activities of sesamins are enhanced. | 11-06-2008 |
20080275111 | Novel Use of Lignan Compounds - The present invention relates to the novel use of lignan compounds represented by Formula I. More particularly, the present invention relates to a pharmaceutical composition for treating or preventing a brain disease, comprising a lignan compound represented by Formula I or a | 11-06-2008 |
20080319055 | Cooling Compounds - A method of providing a cooling sensation to the skin or the mucous membranes of the body by applying thereto a compound of Formula I | 12-25-2008 |
20090012157 | Sesamol Derivatives as Novel Inhibitors of Arachidonic Acid Formation - The invention relates to a novel class of inhibitor of arachidonic acid useful for treating inflammatory conditions. Specifically, the invention relates to hydrophobic and hydrophilic derivatives of sesamol that confer lower toxicity and increased circulatory lifetimes than pure sesamol. | 01-08-2009 |
20090042976 | Antimicrobial therapy for bacterial infections - The disclosure provides a molecular genetic approach of targeted mutagenesis and heterologous expression, coupled with in vitro and in vivo models of bacterial pathogenesis, to demonstrate that the | 02-12-2009 |
20090118363 | SESAMIN-CLASS COMPOUND-CONTAINING FOODS OR BEVERAGES FOR ANIMALS - Methods for treating coats and/or body odors of animals are provided. Foods and beverages for nonhuman animals that can be used in the methods are provided. | 05-07-2009 |
20090137664 | SAURURUS CERNUUS COMPOUNDS THAT INHIBIT CELLULAR RESPONSES TO HYPOXIA - Compounds and compositions that effectively block hypoxia-inducible factor-1 function, and methods of use thereof. The compounds and compositions of the present invention are useful in the prevention and treatment of cancer, stroke, heart disease, ocular neovascular diseases, and arthritis. | 05-28-2009 |
20090163582 | Stable Pesticide Concentrates and End-Use Emulsions - Pesticide concentrates are provided containing an emulsifier that is an EPA list 4 inert and is a polyglycerol fatty acid ester, a sorbitan fatty acid ester or a combination thereof, a pesticide and a solvent that is either a EPA list 3 inert of acetyl ester, EPA list 4 inert of a methyl fatty ester, an acetyltributyl citrate, white mineral oil or a combination thereof. The pesticide can be a water-insoluble synthetic pyrethroid, natural pyrethrum, channel blocking insecticide, acetylcholinesterase inhibitor, oxadiazine, organophosphate, neonicotinoid insecticide, thiamethoxam, imidacloprid, acetamiprid, thiacloprid, clothianidin, nitenpyran, insect growth regulator, juvenile hormone mimic, fermentation insecticide, plant oil insecticide acaracide, miticide, fungicide, herbicide and combinations thereof. The pesticide concentrate is diluted with a hydrocarbon solvent, a white mineral oil or a combination thereof and mixed with water. A corrosion inhibitor is added to form a stable water-in-oil emulsion in conjunction with a propellant to make a ready-to-use aerosol for home, garden and public health pest control. | 06-25-2009 |
20090192217 | METHOD AND COMPOSITION FOR TREATING ACNE USING LIGNAN COMPOUNDS - The present invention relates to a method and composition for treating acne using lignan compounds represented by Formula 1. More particularly, the invention relates to an antibacterial composition against acne-causing bacteria, containing lignan compounds represented by Formula 1, as well as a method for treating acne using the same. The lignan compounds represented by Formula 1 are excellent not only in the antibacterial activity of, inhibiting the growth of acne-causing bacteria, but also in thermal stability. Accordingly, the lignan compounds may be useful as antibacterial agents against the acne-causing bacteria, and acne treatment agents. | 07-30-2009 |
20090203773 | Compounds for the Treatment of Non-Autoimmune Type 2 Diabetes Mellitus and/or Syndrome X - The present invention relates to compounds of the formula (I); wherein R | 08-13-2009 |
20090203774 | SUBSTITUTED BENZYL ESTER DERIVATIVE AND USE THEREOF - The present invention relates to a pharmaceutical composition, a food composition or a cosmetic composition, containing one or more kinds of a compound represented by the following formula (I′) | 08-13-2009 |
20090247625 | COMPOSITIONS CONTAINING LIGNAN-CLASS COMPOUNDS - An object of the invention is to provide compositions containing lignan-class compounds as dissolved at high concentrations. The compositions having lignan-class compounds such as sesamin and episesamin dissolved in solvent oils or fats that contain triglycerides of middle-chain fatty acids having 8-12 carbon atoms, preferably triglycerides of caprylic acid and/or capric acid and/or lauric acid can contain the lignan-class compounds stably at higher concentrations than when other solvents are used and, hence, have high enough value as foods and pharmaceuticals. | 10-01-2009 |
20100056621 | AGONISTS OF A BITTER TASTE RECEPTOR AND USES THEREOF - The present invention relates to agonists of the hTAS2R14 bitter taste receptor and its role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or block hTAS2R14 bitter taste transduction or bitter taste response. | 03-04-2010 |
20100063142 | o/w/o EMULSION CONTAINING LIGNAN COMPOUNDS AND COMPOSITION CONTAINING THE SAME - An O/W/O emulsion composition having at least one of lignan-class compounds dissolved in an internal oil phase is disclosed. This composition can be produced by a process comprising the steps of 1) dissolving at least one of lignan-class compounds in oil or fat to prepare a lignan-class compound dissolving liquid; 2) emulsifying the lignan-class compound dissolving liquid in a water phase to form an O/W emulsion; and 3) further emulsifying the O/W emulsion in an oil phase to prepare an O/W/O emulsion. | 03-11-2010 |
20100105769 | PHARMACEUTICAL COMPOSITION CONTAINING DAURINOL FOR THE PREVENTION AND TREATMENT OF CANCERS - The present invention relates to a pharmaceutical composition for the prevention and treatment of cancer comprising daurinol as an active ingredient, more precisely a pharmaceutical composition for the prevention and treatment of cancer comprising daurinol isolated from the medicinal plant of Mongolia, | 04-29-2010 |
20100144863 | COMPOUNDS AND METHODS FOR TREATING AUTISM SPECTRUM DISORDERS - The present invention relates to a compound of the following formula (I): | 06-10-2010 |
20100261785 | COMPOSITIONS CONTAINING SESAMIN-CLASS COMPOUND(S) AND ARACHIDONIC ACID CLASS COMPOUND(S) - A method by which the physiological activities of sesamin-class compounds can be efficiently exhibited and enhanced, as well as an effective compound that can be combined with the sesamin-class compounds to this end. By using sesamin-class compounds in combination with more than specified proportions of arachidonic acid class compounds, the physiological activities of the sesamin-class compounds, for example, their anti-fatigue action is synergistically enhanced to provide compositions that are safe in humans and non-human animals and which hence can be ingested continuously. | 10-14-2010 |
20110071221 | METHOD FOR TREATING CONDITIONS MEDIATED BY PPAR USING MACELIGNAN - Disclosed is a method for treating PPAR (peroxisome proliferator activated receptor)mediated diseases, such as diabetes mellitus and diabetic complications, which includes administering to a subject an effective amount of macelignan represented by the following Formula (I): | 03-24-2011 |
20110118346 | NOVEL USE OF LIGNAN-TYPE COMPOUNDS OR EXTRACT OF NUTMEG OR ARIL OF NUTMEG COMPRISING THE SAME - The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening. | 05-19-2011 |
20110178171 | COMPOUNDS FOR CANCER THERAPY - A method of inhibiting the cellular proliferation of at least one selected from the group consisting of androgen dependent prostate cancer cells, androgen independent prostate cancer cells, oral cancer cells, liver cancer cells (hepatoma), and gastric cancer cells in a subject is provided, wherein the method comprises administrating to the subject an effective amount of an active component selected from the group consisting of Z form isochaihulactone (Z-K8) of the following formula (I), E form isochaihulactone (E-K8) of the following formula (II), a pharmaceutically acceptable salt of Z-K8 or E-K8, a pharmaceutically acceptable ester of Z-K8 or E-K8, and combinations thereof: | 07-21-2011 |
20120029069 | Compound Extracted From Antrodia Cinnamomea and Pharmaceutical composition comprising the same - This invention relates to a novel compound extracted from | 02-02-2012 |
20120095092 | AMIDE DERIVATIVES OF BENZENE-SULFONANILIDE, PHARMACEUTICAL COMPOSITION THEREOF AND METHOD FOR CANCER TREATMENT USING THE SAME - The invention provides a compound of formula (I), a pharmaceutical composition thereof, a method of preparing a medicament for the treatment of a cancer, and a method of treating cancers. The invention exhibits merits against cancers such as significantly higher potency and effectiveness over a broader range of cancers. In formula (I), R | 04-19-2012 |
20120122970 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE) - The present invention includes insecticidal carbamates that are useful, for example, for the control of insects, such as mosquitoes, which can be used in applications where exposure to and/or contact with humans is likely. The insecticides of the present invention include phenyl N-methyl carbamates and compositions comprising them that exhibit species-selective inhibition of acetylcholinesterase (AChE) and are preferably toxic to mosquitoes but not humans. Of particular interest are compounds of Formula (I) and Formula (II): | 05-17-2012 |
20120190738 | INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) - The present invention relates to compounds of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof. | 07-26-2012 |
20120208874 | SUBSTITUTED ALKYNYL PHENOXY COMPOUNDS AS NEW SYNERGISTS IN PESTICIDAL COMPOSITIONS - A composition comprising an alkynyl phenoxy compound of Formula (I) as a synergist and a pesticidal active ingredient is described, wherein R | 08-16-2012 |
20120302632 | DIETARY CONTROL OF ARACHIDONIC ACID METABOLISM - Compositions for the treatment of symptoms of inflammatory disorders may include gamma-linolenic acid or dihomogammalinolenic acid, an inhibitor of Δ | 11-29-2012 |
20130079396 | Anticancer and Tubulin Polymerisation Inhibition Activity of Benzylidene Indanones and Process of Preparing the Same - The present invention relates to benzylidene indanones of general formula 1. The compounds exhibited tubulin polymerisation inhibition. A series of compounds 2-benzylidene 3-(3,4,5-trimethoxyphenyl) indanones having general formulae | 03-28-2013 |
20130116315 | COMPOSITION FOR THE PREVENTION OR TREATMENT OF OBESITY, DYSLIPIDAEMIA, FATTY LIVER OR INSULIN RESISTANCE SYNDROME, COMPRISING PIPERONAL AS AN ACTIVE INGREDIENT - Provided is a composition for the prevention or treatment of obesity, dyslipidaemia, fatty liver or insulin resistance syndrome, comprising piperonal as an active ingredient. The composition of the present invention can be used to advantage as a drug or functional food composition which not only exhibits activity in the prevention or treatment of obesity, hyperlipidaemia or fatty liver but which also causes a significant reduction in fasted blood sugar and blood insulin concentration and hence has an effect in improving Type-2 diabetes or insulin resistance and also improves metabolic disorder which is closely associated therewith. | 05-09-2013 |
20130150436 | POLYACETYLENE COMPOUND, AN EXTRACT CONTAINING THE SAME AND APPLICATION THEREOF - A polyacetylenes and application thereof. The polyacetylenes is isolated from an extract of the sporophores of | 06-13-2013 |
20130253048 | Pharmaceutical Composition for Promoting Osteogenesis Containing Axial-equatorial Aryl-oriented Furofuran-type Lignan, and Pharmaceutical Preparation, Functional Food Product, and Health Food Product Comprising Composition - Provided is a composition that, even when used in a very small amount, has the effect of improving bone density and promoting bone growth, and has few side effects, and also provided are a pharmaceutical preparation for promoting bone growth, functional food product, and health food product containing the composition as an active ingredient. The composition can be obtained from any plant part selected from the group consisting of the bud, leaf, bark or wood of a plant belonging to the family Magnoliaceae. The composition comprises at least one selected from the group consisting of fargesin and physiologically acceptable salts, hydrates, and glycosides thereof. The pharmaceutical preparation, functional food product, and health food product comprising this composition as an active ingredient sufficiently improve bone density and promote bone growth, even when used in small amounts, and therefore realize preventive and/or therapeutic effects against bone disease etc. such as osteoporosis. | 09-26-2013 |
20130267588 | HYDROXYTYROSOL ETHERS - The invention relates to hydroxytyrosol ethers derived from fatty alcohols and phenolic compounds of olive oil and the salts, solvates and hydrates thereof, which have an affinity for type 1 cannabinoid receptors (CB1) and which can: prevent the oxidation of low-density lipoprotein (LDL); and modulate the actions regulated by said receptor, such as inducing satiety, controlling intake and reducing body fat. | 10-10-2013 |
20140088186 | COMPOSITION CONTAINING ARYLNAPHTHALENE LIGNAN DERIVATIVE FOR PREVENTING AND/OR TREATING DEMENTIA - A composition for preventing and/or treating dementia and ameliorating memory impairment and/or improving memory, comprising one or more arylnaphthalene lignan derivatives, such as Justicidin A, 5-methoxyjusticidin A, Chinensinaphthol, and a pharmaceutically-acceptable salt thereof, as active ingredient. | 03-27-2014 |
20140194506 | Use of Potassium Piperonyl Pentadienoate for Lowering Blood Lipid - The invention provides the use of potassium piperonyl pentadienoate for lowering blood lipid, including the use of the potassium piperonyl pentadienoate in the preparation of medicaments and health-care products for lowering serum total cholesterol, lowering low density lipoprotein cholesterol, lowering triglyceride as well as preventing the decrease of high density lipoprotein cholesterol. | 07-10-2014 |
20150038574 | Opsin-Binding Ligands, Compositions and Methods of Use - Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed. | 02-05-2015 |
20150305367 | FROZEN CONFECTION - A frozen confection comprising from 0.002 wt % to 1 wt % of one or more compounds selected from the group consisting of benzyl cinnamate, piperonal, 4-methoxybenzaldehyde, and 4-hydroxybenzaldehyde is provided. A product for use in improving mood is also provided. | 10-29-2015 |
20150313222 | COMPOSITIONS AND METHODS FOR PREVENTING OR REDUCING RESISTANCE OF INSECTS TO INSECTICIDES - A method for preventing or reducing resistance to a pesticide of a substrate pest, which method comprises the administration to the substrate or the pest of a composition comprising: (a) a rapid-release formulation of an inhibitor of a factor causing or contributing to the resistance of the pest to the pesticide; and, substantially simultaneously, (b) a non-rapid release formulation of the pesticide. The invention also provides compositions suitable for use in such a method. | 11-05-2015 |
20160143877 | COMPOSITION FOR SUPPRESSING ADIPOCYTE DIFFERENTIATION, FOR REDUCING FAT ACCUMULATION AND/OR FOR PROMOTING ADIPONECTIN SECRETION AND USAGE FOR SAID COMPOSITION - The present invention relates to a composition for suppressing adipocyte differentiation, for reducing fat accumulation in adipocytes and/or for promoting adiponectin secretion from adipocytes, including sesaminol as an active component. The present invention also relates to a method for suppressing adipocyte differentiation, for reducing fat accumulation in adipocytes and/or for promoting adiponectin secretion of adipocytes, including administering a composition including sesaminol as an active component. | 05-26-2016 |
20160175280 | COMPOSITION FOR PROMOTING COLLAGEN PRODUCTION, FOR PROMOTING ELASTIN PRODUCTION AND/OR FOR PROMOTING KERATINOCYTE MIGRATION AND USAGE THEREFOR | 06-23-2016 |
20160193180 | COMPOSITION FOR PREVENTING AND TREATING IMMUNE DISEASES CONTAINING DAURINOL COMPOUND AS ACTIVE INGREDIENT | 07-07-2016 |
514465000 | The hetero ring is substituted | 10 |
20080255228 | Ascorbic Acid Complexes for Skin Care Including Treatment of Dark Skin & Wrinkles - This invention relates to certain complexes of ascorbic acid and its derivatives with certain aryl alkyl ketones; said complexes having being formed via a kinetically-controlled process, and having general chemical formula (I) in FIG. | 10-16-2008 |
20080312317 | 12 MEMBERED-RING MACROLACTAM DERIVATIVES - There provided a 12-membered-ring macrolactam derivative having antitumor activity: A compound represented by Formula (1) or a salt thereof. In this Formula, R | 12-18-2008 |
20090163583 | Process and an Apparatus for Producing Episesamin-Rich Compositions - To provide a process and an apparatus by means of which a composition that contains episesamin in a concentration greater than 50 wt % on the basis of the sum weight of sesamin and episesamin can be produced conveniently and at high yield. | 06-25-2009 |
20090286872 | Oral Composition Comprising Dha and Genistein for Enchancing Skin Properties - Composition for oral consumption in the form of a substantially 5 homogeneous aqueous emulsion, suspension or dispersion comprising genistein and docosahexaenoic acid (DHA) and less than 1% by weight of soy protein, wherein the weight ratio of genistein to DHA is in the range of from 1:100 to 1:1, the composition comprises genistein in an amount of from 0.0001% to 0.1% by 10 weight and the genistein and DHA exhibit an anti-ageing effect on skin. | 11-19-2009 |
20100137428 | OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS - The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. | 06-03-2010 |
20110257260 | 3,4-METHYLENEDIOXYPHENYL INHIBITORS OF GABA AMINOTRANSFERASE AND/OR GABA REUPTAKE TRANSPORTER INHIBITOR - The present invention relates to new 3,4-methylenedioxyphenyl inhibitors of GABA aminotransferase activity and/or GABA reuptake transporter activity, pharmaceutical compositions thereof, and methods of use thereof. | 10-20-2011 |
20110294876 | CYCLOHEXYL CARBAMATE COMPOUNDS AS ANTI-AGEING ACTIVES - The present invention relates to the cosmetic, dermatological or therapeutic use of compounds of formula (I) given below, in particular as anti-ageing actives. | 12-01-2011 |
20120252890 | PROCESS AND COMPOUNDS FOR THE MANUFACTURE OF OSELTAMIVIR AND ANALOGS THEREOF, AND NEW ANTIVIRAL AGENTS - The present application relates to processes for the preparation of intermediates useful in the manufacture of oseltamivir and the H | 10-04-2012 |
20130197074 | USE OF ADRENERGIC BETA-3-RECEPTOR AGONISTS IN ANTI-AGING - A method for treating an aging-related disease is disclosed comprising administering to a subject a pharmaceutical composition comprising an adrenergic beta-3-receptor agonist. | 08-01-2013 |
20140088187 | ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF - The present invention relates to novel aryl sulfonamide compounds use of such compounds in the inhibition of androgen receptor and in the treatment of various diseases, disorders or conditions related to androgen receptor. | 03-27-2014 |
514466000 | Nitrogen containing | 16 |
20080221206 | Compounds Derived From Lidocaine, Pharmaceutical Compositions, Use And Method Of Treatment, Prevention Or Inhibition Of Disease - The present invention relates to lidocaine derived compounds, which present less anesthetic activity than lidocaine itself, but with more anti-inflammatory and spasmolytic activity than said lidocaine as well as pharmaceutical compositions with at least one of these compounds or a salt of those as active principle and to the use of such compositions to treat, prevent or inhibit atopic diseases including asthma, rhinitis, allergic urticaria, chronic lung inflammation associated with eosinophilia, following the example of atopic asthma and chronic intestinal inflammation, as colitis for instance. The pharmaceutical composition may be available in spray form, solution, suspension, emulsion destinated to be applied by nebulization, or in any of the pharmaceutical available forms for oral or injectable use. | 09-11-2008 |
20090054519 | DERIVATIVES OF MONOSACCHARIDES AS 5-LIPOXYGENASE INHIBITORS - The present invention relates to the use of derivatives of monosaccharides as 5-lipoxygenase inhibitor. | 02-26-2009 |
20090082431 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF - The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2. | 03-26-2009 |
20090124686 | GSK-3 INHIBITORS - The invention relates to urea derivatives of formula (I) as inhibitors of glycogen synthase kinase 3β, GSK-3, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which GSK-3 is involved, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. | 05-14-2009 |
20090239944 | Novel Use of Organic Compounds - The present invention relates to compounds of the formula I | 09-24-2009 |
20100184851 | INHIBITION OF CELL PROLIFERATION - Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell proliferation disorder such as cancer, are provided. | 07-22-2010 |
20100292317 | ANTIMICROBIAL AND RADIOPROTECTIVE COMPOUNDS - The present invention relates to a method of treatment and/or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which X and Y are either the same or different and selected from a heteroatom; is a double or single bond depending on the heteroatoms X and Y; R | 11-18-2010 |
20100311827 | Chlorogenic acid derivatives and their use as anti-fungal agents - The invention provides chlorogenic acid derivatives of Formula (I) that are capable of inhibiting the growth of fungal cells and are useful as anti-fungal agents. The invention further provides the methods of inhibiting the growth of fungal cells and methods of treating a fungal infection in an animal by administering to the animal an effective amount of a compound of Formula I, either alone or in combination with another anti-fungal agent. | 12-09-2010 |
20110112187 | Use Of Tranilast And Derivatives Thereof For The Therapy Of Neurological Conditions - The present invention relates to the use of tranilast and derivatives thereof for the preparation of a pharmaceutical composition for treating and/or preventing a neuronal condition where there is a need of neuroprotection and neuroregeneration. The invention furthermore relates to the use of tranilast and derivatives thereof for the in vitro differentiation of neuronal stem cells and the use of such pre-treated cells for stem cell therapy von neurological conditions. | 05-12-2011 |
20110207810 | N1-BENZO[1,3]DIOXOL-5-YLMETHYL-N2-SUBSTITUTED BIGUANIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME - The present invention provides an N1-benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient. The inventive N1-benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative exhibits improved blood glucose level- and lipid level-lowering effects even with a reduced dosage as compared to conventional drugs, and thus, it is useful for preventing or treating diabetes, metabolic syndromes such as insulin-independent diabetes, obesity and atherosclerosis, or a P53 gene defect-related cancer. | 08-25-2011 |
20120184607 | USE OF PIPERPHENTONAMINE OR SALTS THEREOF IN MANUFACTURE OF MADICAMENTS FOR PREVENTION/TREATING BRAIN DISEASES - The present invention relates to the use of piperphentonamine or pharmaceutically acceptable salts thereof to prevent/treat encephalopathy in mammals, and the use of a combination of piperphentonamine or pharmaceutically acceptable salts thereof and other medicines in manufacture a medicine to prevent/treat encephalopathy in mammals. The mammals include human beings, and the encephalopathy includes cerebral injury related diseases or cerebrovascular diseases. The cerebrovascular diseases refer to cerebral ischemia, cerebral ischemia/reperfusion-induced injury or cerebral hemorrhage. The cerebral hemorrhage includes hypertensive cerebral hemorrhage, cerebral hemorrhage secondary to infarction, tumor cerebral hemorrhage or cerebral hemorrhage caused by arteritis. The cerebral ischemia means carotid system cerebral ischemia or vertebrobasilar cerebral ischemia. | 07-19-2012 |
20120225935 | ANTIMICROBIAL AND RADIOPROTECTIVE COMPOUNDS - Disclosed is a method of treatment and/or prophylaxis of a microbial infection, employing compounds of formula (I), in which X and Y are either the same of different and selected from a hereroatiom; is a double or single bond depending on the heteroatoms X and Y; R | 09-06-2012 |
20130165507 | NEW GUANIDINE DERIVATIVES IN CINNAMIC SERIES - The invention relates to novel guanidine derivatives in the cinnamic series of general formula (I): | 06-27-2013 |
20130178520 | METHODS OF TREATMENT USING ARYLCYCLOPROPYLAMINE COMPOUNDS - Described herein are methods of treating Parkinson's disease using arylcyclopropylamine compounds. | 07-11-2013 |
20150011621 | FORMYLATED XANTHOCILLIN ANALOGUES AS NEUROPROTECTIVE AGENTS - Formylated xanthocillin analogs can be used in the treatment of neurodegenerative diseases. The analogs can be prepared synthetically, and at least some of the analogs can be obtained from a microorganism strain of the | 01-08-2015 |
20150105456 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof - The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2. | 04-16-2015 |