Class / Patent application number | Description | Number of patent applications / Date published |
514373000 | Polycyclo ring system having the thiazole ring as one of the cyclos | 46 |
20080242710 | Pharmaceutically Active Tetrahydro-Pyrrolo[1,2-B]Isothiazole 1,1-Dioxides - 3a,4,5,6-Tetrahydro-pyrrolol,2-b]-isothiazoles wherein the sulphur is in the form of a dioxide and their use for the treatment or prevention of disorders mediated by interactions of LFA-1 with its ligands involved in cell adhesion, migration and activation. | 10-02-2008 |
20080262055 | Macrocyclic Acyl Guanidines as Beta-Secretase Inhibitors - There is provided a series of heterocyclic-containing macrocyclic acyl guanidines of Formula (I) or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, | 10-23-2008 |
20080319035 | Microbicidal composition - Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one. | 12-25-2008 |
20090023790 | Microbicidal composition - Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one. | 01-22-2009 |
20090062355 | Pharmaceutical Product - An agent for suppressing the production of various cytokines (IL-8 and the like) and inflammatory mediators, an agent for suppressing the expression of COX-II and the like, or an inhibitor of various phosphorylation enzymes (ATF2 and the like), which contains a TLR signaling inhibitory substance, preferably a compound represented by the formula (I) or the formula (II) | 03-05-2009 |
20090105320 | Biodal Compositions Containing 1,2-Benzisothiazolin-3-One And 1,2-Dibromo-2,4-Dicyanobutane - This invention relates to biocidal compositions in the form of solutions, containing a) 1,2-benzisothiazolin-3-one (formula I) and/or a salt thereof, preferably its alkali metal or ammonium salt, in particular its lithium, sodium or potassium salt; b) 1,2-dibromo-2,4-dicyanobutane (formula (II)); c) at least one solvent which is a mixture of a compound of the formula III with glycerol (formula (III)); wherein R | 04-23-2009 |
20090137646 | 1,2 Benzoisothiazole Derivative, and Agricultural or Horticultural Plant Disease- Controlling Agent - A 1,2-benzoisothiazole derivative or a salt thereof is not harmful to a crop and is remarkably effective against agricultural or horticultural plant diseases such as | 05-28-2009 |
20090203756 | Biocidal Compositions - The present invention relates to biocidal compositions comprising at least one biocidal active substance and at least one solvent from the group of polyglycol monobutyl ethers, and to their use as preservatives and disinfectants. More specifically, the invention provides compositions comprising
| 08-13-2009 |
20090306157 | Antiseptic Alginate Preparation - An antiseptic preparation is provided for the production of wound dressings or bandages. The preparation includes at least one alginate and at least one antiseptically active substance selected from the group biguanide derivatives, octenidine and taurolidine. Processes for the production of the antiseptic preparations, and the use thereof, are also provided. | 12-10-2009 |
20090312377 | DERIVATIVES OF BENZO[D]ISOTHIAZOLES AS HISTONES DEACETYLASE INHIBITORS - The invention relates to derivatives of benzo[d]isothiazoles as histone deacetylase inhibitors, selected from among compounds of general formula (Ia) and (Ib) or one of the salts thereof, particularly one of the pharmaceutically acceptable salts thereof, or one of the corresponding solvates thereof. These compounds are histone deacetylase enzyme inhibitors and are suitable as pharmacologically active agents in a medicament for the treatment and/or prophylaxis of disorders or diseases associated to histone deacetylases. The invention also describes a process for obtaining the mentioned compounds and the pharmaceutical compositions containing them | 12-17-2009 |
20100016390 | STABLE, LOW VOC, LOW VISCOUS BIOCIDAL FORMULATIONS AND METHOD OF MAKING SUCH FORMULATIONS - A stable, low VOC, low viscosity biocide formulation comprising an effective amount of at least one biocide, 1,2-benzisothiazolin-3-one (BIT), and a polyglycol liquid carrier of formula (I): R—O-(AO) | 01-21-2010 |
20100160396 | Insecticidal Compositions of 2-Cyanobenzene Sulfonamide Compounds and Isomeric Forms Thereof Having Improved Effect - The present invention comprises 2-cyanobenzenesulfonic acid amides of the formula (I) and isomeric forms thereof (I-A) and (I-B) | 06-24-2010 |
20100173959 | METHOD OF PROTECTING A PLANT PROPAGATION MATERIAL, A PLANT, AND/OR PLANT ORGANS - A method of controlling or preventing pest damage in a plant propagation material, a plant, and/or plant organs that grow at a later point in time, which comprises applying on the plant propagation material or locus thereof a compound I or II represented by formula (I) and (II) wherein R1 is represented, for example, by H; R6 is represented, for example, by H; R2 is represented, for example, by halogen; R3 to R5 is represented, for example, by H; and n is either 0 or 2; or an enantiomer, diastereomer, or salt, thereof. | 07-08-2010 |
20100234436 | Pest control agent in form of stable suspension - Disclosed is a pest control agent in the form of a suspension, which exhibits excellent dispersion stability for a long time without forming a hard cake due to settling and separation of solid particles or without losing fluidity due to gelation even when a cationic pest control active ingredient and/or an acid is used. Specifically disclosed is a pest control agent in the form of a suspension, which contains (a) a cationic pest control active ingredient and/or an acid, (b) a nonionic thickening agent, (c) a nonionic surface active agent, (d) a solid active ingredient and (e) water. | 09-16-2010 |
20100234437 | PESTICIDE COMPOSITIONS - This invention is related to the field of compositions useful in the control of pests that eat cellulose, such as, termites, where said composition is compacted and where said composition comprises alpha-cellulose, water, and a pesticide. | 09-16-2010 |
20110028525 | Synergistic Microbicidal Compositions - This invention relates to synergistic combinations of selected isothiazolin-3-one microbicides in combination with a second microbicide or formulation ingredient or raw material. The combinations have greater efficacy than would be expected from combinations of the individual components. The combinations include mixtures of (a) Methyl-4-isothiazolin-3-one or (b) 1,2-Benzisothiazolin-3-one with one or more of a variety of other compounds. | 02-03-2011 |
20110071200 | 3-AMINO-BENZO [D] ISOTHIAZOLE DIOXIDE DERIVATIVES AND THEIR USE AS PESTICIDES - A compound of Formula (I) or Formula (II) where W is C—R | 03-24-2011 |
20110077278 | Antifungal compositions and methods - A combination product including a mixture of 3-iodpropynyl-N-n-butylcarbamate (“IPBC”) and 2-n-N-butyl-1,2-benzisothiazolin-3-one (“BBIT) for use as a fungicide and growth inhibitor in industrial applications. Combination products of the present invention are effective for inhibiting the growth of microorganisms, and exhibit a synergistic antifungal effect against fungi such as, for example, | 03-31-2011 |
20110184034 | Severe sepsis preventive therapeutic agent - The present invention provides an agent for the prophylaxis or treatment of severe sepsis, which contains a compound represented by the formula (I): | 07-28-2011 |
20110207786 | Potentiated Biocidal Compositions and Methods of Use - The present technology relates to biocidal compositions and methods that contain and utilize at least one biocidal agent and at least one potentiator system wherein the resultant combination has an enhanced biocidal efficacy. The present technology also discloses a rapid screening assay for determining biocidal compositions with enhanced efficacy, e.g., a microbial contact kill time of 5 minutes or less. Further, the present technology provides a method of determining biocidally effective concentrations of biocidal compositions comprising at least one biocidal agent and at least one potentiator system. | 08-25-2011 |
20110207787 | ANTIMICROBIAL COMPOSITIONS - What is described herein are antimicrobial compositions which are defined blends of a 1,2-diol and phenoxyethanol which show broad activity against bacteria, fungi and mold spores. This activity is potentiated by the addition thereto of small amounts of a co-biocide for which the blend acts as a delivery system for the otherwise water-insoluble co-biocide. | 08-25-2011 |
20110237632 | ANTIFOULING COMBINATION COMPRISING 4-BROMO-2-(4- CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRROLE-3-CARBONITRILE - The present invention relates to combinations of 4-bromo-2-(4-chloro-phenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile, or a salt thereof, and the biocidal compound 2-butyl-1,2-benzisothiazol-3(2H)one (butylBIT), or a salt thereof, which provide an improved protecting effect against fouling organisms. More particularly, the present invention relates to compositions comprising a combination of 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile, or a salt thereof, together with the biocidal compound butylBIT; in respective proportions to provide a synergistic effect against fouling organisms and the use of these compositions for protecting materials against fouling organisms. | 09-29-2011 |
20110257233 | BENZOISOTHIAZOLONES AS INHIBITORS OF PHOSPHOMANNOSE ISOMERASE - The disclosure provides new compounds and compositions thereof, and methods for treating or ameliorating a disorder relating to CDG-Ia. In particular, the disclosure provides benzoisothiazolone inhibitors of PMI, which have been synthesized and their ability to drive glycosylation has been demonstrated. The disclosure provides two synthetic routes for these compounds, including a new copper-catalyzed N-arylation reaction amenable to parallel derivitization. The disclosed compounds represent potent inhibitors of PMI, and their dose-dependent efficacy in cell-based models of glycosylation have been demonstrated. In addition, the disclosed compounds are selective over PMM and therefore, are useful in treating or ameliorating a disorder relating to CDG-Ia. | 10-20-2011 |
20120035229 | COMPOSITIONS CONTAINING 1,2-BENZISOTHIAZOLIN-3-ONE - In a first aspect of the present invention, there is provided a composition comprising 1,2-benzisothiazolin-3-one dispersed in an aqueous medium and further comprising one or more polysaccharide; wherein either
| 02-09-2012 |
20120077856 | PHARMACEUTICAL PRODUCT - An agent for suppressing the production of various cytokines (IL-8 and the like) and inflammatory mediators, an agent for suppressing the expression of COX-II and the like, or an inhibitor of various phosphorylation enzymes (ATF2 and the like), which contains a TLR signaling inhibitory substance, preferably a compound represented by the formula (I) or the formula (II) | 03-29-2012 |
20120129899 | SYNERGISTIC ANTIMICROBIAL COMPOSITION OF 1,2-BENZISOTHIAZOLIN-3-ONE AND TRIS(HYDROXYMETHYL)NITROMETHANE - A synergistic antimicrobial composition containing 1,2-benzisothiazolin-3-one and tris(hydroxymethyl)nitromethane. | 05-24-2012 |
20120172404 | ANTIMICROBIALLY EFFECTIVE USE SOLUTIONS COMPRISING COMBINATIONS OF ISOTHIAZOLONES AND AMINES - The invention relates to a microbicidal use solution which comprises a) one or more isothiazolin-3-ones and b) one or two organic amines selected from N-dodecylpropane-1,3-diamine and bis(aminopropyl)-dodecylamine and optionally c) one or more oxidizing agents. The use solution is preferably in the form of technical and domestic products. | 07-05-2012 |
20120184588 | COMPOSITIONS OF DIBROMOMALONAMIDE AND THEIR USE AS BIOCIDES - A biocidal composition comprising 2,2-dibromomalonamide and an isothiazolinone-based biocide, and its use for the control of microorganisms in aqueous and water-containing systems. | 07-19-2012 |
20120322839 | AQUEOUS DISPERSIONS - There is provided a method of making an aqueous dispersion wherein said dispersion comprises (A) one or more thickener and (B) solid particles of 1,2-benzisothiazolin-3-one, wherein said method comprises the steps of (a) forming an aqueous mixture (I) comprising water, a dissolved salt of 1,2-benzisothiazolin-3-one, and optionally one or more thickener, wherein the pH of said aqueous mixture (I) is 8.5 or higher, and (b) subsequently forming said aqueous dispersion by mixing together, in any order, components, wherein said components comprise an acid, said aqueous mixture (I), and optionally one or more thickener, wherein the pH of said dispersion is 1.5 to 7.5. Also provided is an aqueous dispersion made by that method. | 12-20-2012 |
20130046000 | COMPOUNDS FOR SUPPRESSING A PERIPHERAL NERVE DISORDER INDUCED BY AN ANTI-CANCER AGENT - The present invention provides a medicament that suppresses (or mitigates) various neurological symptoms caused by a peripheral nerve disorder induced by an anti-cancer agent. | 02-21-2013 |
20130090361 | Biocidal compositions - The present invention relates to storage-stable biocidal compositions comprising at least one halogen-free isothiazolinone such as in particular 2-methyl-2H-isothiazol-3-one (MIT) and/or 1,2-benzisothiazolin-3-one (BIT) and/or salts thereof, and also stabilizing amounts of copper(II) ions, to a method for preserving technical materials by means of the aforementioned biocidal compositions, and to the technical materials treated therewith. | 04-11-2013 |
20130109727 | BIOCIDE | 05-02-2013 |
20130109728 | BIOCIDE COMPOSITION | 05-02-2013 |
20130131130 | SYNERGISTIC PRESERVATIVE COMPOSITIONS - A preservative composition comprising: (a) 1,2-Benzisothiazolin-3-one (BIT); (b) 3-Iodo-2-propynyl carbamate (IPBC); and (c) a mixture of 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-Methyl-4-isothiazolm-3-one (MIT). | 05-23-2013 |
20130203825 | PHOSPHATE-FREE HIGHLY CONCENTRATED AQUEOUS DISPERSION COMPOSITION OF BIOCIDES AND PROCESS FOR PREPARING THE SAME - A phosphate-free, highly-concentrated aqueous dispersion composition comprising at least one biocide, sulfosuccinate based surfactant, block copolymer, suspending agent, and optionally an antifoaming agent and desired additives if any. The composition of the present application is significantly stable against heat, cold, transit, storage and dilution for at least 18 months. The preferred biocides of the dispersion composition are 2-meth-4-isothiazolin-3-one (MIT), 1,2-Benzisothiazolin-3-one (BIT), 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT), 2-Octyl-4-isothiazolin-3-one (Off) 3-Iodo-2-propynylbutyl carbamate (IPBC), oxyfluorfen, thiabendazole, terbutryn, zinc pyrithione (ZnPy), bronopol, folpet, diiiron, dehydroacetic acid (DHA), dazomet and carbendazim alone or in combination. Also disclosed is a process for preparing the dispersion composition and appropriate applications thereof. | 08-08-2013 |
20140024688 | Potentiated Biocidal Compositions and Methods of Use - The present technology relates to biocidal compositions and methods that contain and utilize at least one biocidal agent and at least one potentiator system wherein the resultant combination has an enhanced biocidal efficacy. The present technology also discloses a rapid screening assay for determining biocidal compositions with enhanced efficacy, e.g., a microbial contact kill time of 5 minutes or less. Further, the present technology provides a method of determining biocidally effective concentrations of biocidal compositions comprising at least one biocidal agent and at least one potentiator system. | 01-23-2014 |
20140100253 | SYNERGISTIC ANTIMICROBIAL COMPOSITION OF 1,2-BENZISOTHIAZOLIN-3-ONE AND TRIS(HYDROXYMETHYL)NITROMETHANE - A synergistic antimicrobial composition containing 1,2-benzisothiazolin-3-one and tris(hydroxymethyl)nitromethane. | 04-10-2014 |
20140121251 | MICROBICIDAL COMPOSITION - Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one. | 05-01-2014 |
20140121252 | MICROBICIDAL COMPOSITION - Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one. | 05-01-2014 |
20140121253 | MICROBICIDAL COMPOSITION - Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one. | 05-01-2014 |
20140128440 | MICROBICIDAL COMPOSITION - Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one. | 05-08-2014 |
20140296310 | METHODS OF TREATING BACTERIAL INFECTIONS WITH 1,2-BENZISOTHIAZOLINONE AND ISOINDOLINONE DERIVATIVES - Methods of treating, preventing and ameliorating bacteria! infections with 1,2-benzisothiazolinone and isoindolinone derivatives are disclosed. Pharmaceutical compositions containing 1,2-benzisothiazolinone and isoindolinone derivatives are useful for treating bacteria! infections caused by drug resistant strains of bacteria, including but not limited to methicillin and vancomycin bacterial organisms. | 10-02-2014 |
20150051256 | COMPOUNDS FOR SUPPRESSING A PERIPHERAL NERVE DISORDER INDUCED BY AN ANTI-CANCER AGENT - The present invention provides a medicament that suppresses (or mitigates) various neurological symptoms caused by a peripheral nerve disorder induced by an anti-cancer agent. | 02-19-2015 |
20150313881 | Therapeutic Methods for Type I Diabetes - The invention relates to the treatment and prevention of type I diabetes. More specifically, the invention relates to compounds that treat or prevent the body's immune system from destroying β-cells (i.e., insulin-producing cells in the pancreatic islets of Langerhans) by inhibition of JNK2, selective inhibition of JNK2, or inhibition of the expression of the MAPK9 gene or gene product. In one embodiment, the present invention contemplates the diagnosis, identification, production, and use of compounds which modulate MAPK9 gene expression or the activity of the MAPK9 gene product including but not limited to, JNK2, the nucleic acid encoding MAPK9 and homologues, analogues, and deletions thereof, as well as antisense, ribozyme, triple helix, antibody, and polypeptide molecules as well as small inorganic molecules. The present invention contemplates a variety of pharmaceutical formulations and routes of administration for such compounds. | 11-05-2015 |
20150327550 | ENVIRONMENT-FRIENDLY, BIODEGRADABLE, VOC-FREE, NON-CORROSIVE AQUEOUS SOLUTION OF 1, 2-BENZISOTHIAZOLIN-3-ONE (BIT) AND PROCESS FOR PREPARING THE SAME - What is described herein is an environment-friendly, biodegradable, non-corrosive aqueous solution of isothiazolin-3-one comprising: (i) at least about 5 wt. % to about 50 wt. % of 1,2-benzisothiazolin-3-one (BIT); (ii) about 5 wt. % to 15 wt. % of neutralizing agent; (iii) about 0.01 wt. % to about 20 wt. % of at least one biodegradable chelating agent; (iv) about 0.01 wt. % to about 20 wt. % of at least one alkyl polyglucoside, a solubilizer; (v) about 0.1 wt. % to about 2.0 wt. % of polyvinyl alcohol (PVA), a crystal modifier; and (vi) about 50% to about 85% by wt. of water; and wherein said aqueous solution is free from volatile organic compounds (VOC's), glycerols, polyglycerols, derivatives of glycerols, glycols, polyglycols and/or derivatives of glycols, and wherein, the frozen aqueous solution of isothiazolin-3-one is capable of completely thawing within two hours at room temperature or at about 25° C. to about 30° C. | 11-19-2015 |
20160021884 | STABLE SOLUTIONS OF 1,2-BENZISOTHIAZOLIN-3-ONE - A composition comprises 5-15 wt % of the potassium salt of 1,2-benzisothiazolin-3-one (K-BIT) calculated as 1,2-benzisothiazolin-3-one (BIT), 2-12 wt % of a nonionic surfactant, and at least 70 wt %. The presence of the nonionic surfactant stabilizes an aqueous solution of the composition at a temperature of −5° C. A method of stabilizing an aqueous solution comprising 5-15 wt % of the potassium salt of 1,2-benzisothiazolin-3-one (K-BIT) calculated as 1,2-benzisothiazolin-3-one (BIT) and at least 70 wt % water at a temperature of −5° C., includes the step of incorporating within the aqueous solution an amount of the nonionic surfactant so that the aqueous solution has 2-12 wt % of the nonionic surfactant. | 01-28-2016 |