Entries |
Document | Title | Date |
20080249102 | Hiv Protease Inhibitors - Compounds of the formula I: | 10-09-2008 |
20080275053 | Heterocyclyl Compounds - Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: | 11-06-2008 |
20080280915 | Insecticidal n-substituted (heteroaryl)alkyl sulfilimines - N-Substituted (heteroaryl)alkyl sulfilimines are effective at controlling insects. | 11-13-2008 |
20080312244 | Squaric Acid Derivatives as Protein Kinase Inhibitors - Compounds of the formula I, in which R, X, R | 12-18-2008 |
20090012093 | Receptor Function Regulator - The GPR40 receptor function regulator of the present invention, which comprises a compound having an aromatic ring and a group capable of releasing cation is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like. | 01-08-2009 |
20090054444 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS - Compounds of Formula (I) wherein R | 02-26-2009 |
20090093490 | HETEROCYCLYLETHYLBENZAMIDE DERIVATIVES - A compound of general formula (I): | 04-09-2009 |
20090186900 | COMPOUND - There is provided a compound of Formula I | 07-23-2009 |
20090192167 | Insecticidal and fungicidal composition - An insecticidal and fungicidal composition capable of controlling crop diseases and insect pests at the same time by combining an insecticidal active ingredient and a fungicidal active ingredient is provided. The insecticidal and fungicidal composition is characterized by comprising as active ingredients a compound represented by the general formula (1) or (2) and a compound represented by the general formula (3) or (4). | 07-30-2009 |
20090221596 | Substtituted aryl oximes - The invention relates to compounds of the formula (I) | 09-03-2009 |
20090239875 | Protection of ferulic acid and/or tetramethylpyrazine against retinal ischaemia, glaucoma and siderosis oculi - A method for preventing and/or treating ischaemic and/or iron-related retinal or brain disorders comprising administering an effective amount of ferulic acid (FA), tetramethylpyrazine (TMP) or their pharmaceutically acceptable salt, ester, solvate, hydrate, analogs, metabolite, enantiomer, isomer, tautomer, amide, derivative or prodrug to a subject. The former diseases comprise retinal ischemia, glaucoma as well as brain ischaemia (i.e. stroke, infarction typed). The latter ones comprise age-related macular degeneration, intraocular hemorrhage, siderosis oculi (due to retained intraocular iron), oxidative stress of the retina as well as brain hemorrhage (stroke, hemorrhagic type) or Alzheimer disease. Clinically, FA alone or in combination of TMP can be administered systemically, orally, intravitreously, topically (in form of eyedrops), as well as other routes such as periocular, subconjunctival, and intracamera. | 09-24-2009 |
20090275587 | METHODS OF TREATING ISCHEMIC RELATED CONDITIONS - The present invention relates to methods of treating ischemia-related conditions by administering to a patient in need of such methods certain thiosemicarbazone compounds. Preferred embodiments of the present invention relates to methods of treating specific ischemia-related conditions, including but not limited to Alzheimer's disease, Parkinson's disease, Coronary artery bypass graft surgery, Global cerebral ischemia due to cardiac arrest, focal cerebral infarction, cerebral hemorrhage, hemorrhage infarction, hypertensive hemorrhage. hemorrhage due to rupture of intracranial vascular abnormalities, subarachnoid hemorrhage due to rupture of intracranial arterial aneurysms, hypertensive encephalopathy, carotid stenosis or occlusion leading to cerebral ischemia, cardiogenic thromboembolism, spinal stroke and spinal cord injury, diseases of cerebral blood vessels: e.g., atherosclerosis, vasculitis, Macular degeneration, myocardial infarction, cardiac ischemia and superaventicular tachyarrhytmia. | 11-05-2009 |
20090275588 | NOVEL SULFONAMIDE COMPOUNDS - The invention relates to novel sulfonamide compounds and their use as orexin receptor antagonists. | 11-05-2009 |
20090286799 | METHODS FOR THE TREATMENT OF BRAIN EDEMA - The present invention is based on the discoveries that PAN-811 (1) reduces infarct volume, suppresses brain edema and decreases mortality associated with ischemia; (2) blocks veratridine-induced swelling and neuronal cell death; (3) chelates free calcium and inhibits MMP-9 activity; and (4) blocks calcium-induced neuronal cell death and suppresses glutamate-induced calcium influx into neuronal cells. More particularly, the present invention relates to methods for treating, ameliorating or preventing vasogenic and/or cytotoxic brain edema, by administering to a subject in need thereof certain thiosemicarbazone compounds or pharmaceutically acceptable salts thereof. An example of such a thiosemicarbazone is 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (PAN-811). | 11-19-2009 |
20090325972 | NOVEL CINNAMALDEHYDE DERIVATIVES HAVING IMPROVED SOLUBILITY IN WATER, A METHOD FOR PREPARING THE SAME AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME - Disclosed herein are a novel cinnamaldehyde compound represented by Chemical Formula 1 or pharmaceutically acceptable salts thereof. The cinnamaldehyde compound has improved solubility in water and has inhibitory effects on the growth of cancer cells because it induces cell cycle arrest and cell death. Also disclosed are a method of preparing the cinnamaldehyde compound and an anticancer composition including the compound of Chemical Formula 1. | 12-31-2009 |
20100004253 | BIOMARKERS OF TARGET MODULATION, EFFICACY, DIAGNOSIS AND/OR PROGNOSIS FOR RAF INHIBITORS - Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to Raf kinase inhibition, are measured and identifications or adjustments may be made accordingly. | 01-07-2010 |
20100010000 | AMINO ALCOHOL DERIVATIVE AND IMMUNOSUPPRESIVE AGENT HAVING SAME AS AN ACTIVE INGREDIENT - An amino alcohol derivative useful as an excellent immunosuppressive agent is provided. | 01-14-2010 |
20100029670 | ORGANIC COMPOUNDS - The present invention relates to compounds of formula (I) | 02-04-2010 |
20100056534 | PESTICIDAL COMPOSITIONS - Pesticide compositions and their use in controlling pests are provided. | 03-04-2010 |
20100093745 | THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR DEMYELINATING DISEASE COMPRISING AMINO ALCOHOL DERIVATIVE AS ACTIVE INGREDIENT - A novel therapeutic agent or prophylactic agent for a demyelinating disease is provided. An amino alcohol derivative represented by the general formula (1), | 04-15-2010 |
20100197696 | PESTICIDAL HETEROCYCLIC DIHALOALLYL COMPOUNDS - The invention relates to compounds of formula | 08-05-2010 |
20100324056 | BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS - Compounds of the formula I: | 12-23-2010 |
20100324057 | THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR INFLAMMATORY BOWEL DISEASE COMPRISING AMINO ALCOHOL DERIVATIVE AS ACTIVE INGREDIENT - A novel therapeutic agent or prophylactic agent for an inflammatory bowel disease is provided. An amino alcohol derivative represented by the general formula (1): | 12-23-2010 |
20110046147 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES - The invention relates to 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) inhibitors, the preparation thereof and the use thereof for the treatment and prophylaxis of hormone-related, especially estrogen-related or androgen-related, diseases. | 02-24-2011 |
20110086860 | COMPOUND - A compound represented by Formula (I) is provided: | 04-14-2011 |
20110105518 | THERAPEUTIC AGENT FOR SPINAL CANAL STENOSIS - The main object of the present invention is to provide a novel agent for the treatment of spinal canal stenosis. | 05-05-2011 |
20110124651 | FLUORINE-CONTAINING ORGANOSULFUR COMPOUND AND PESTICIDAL COMPOSITION THEREOF - There is provided a fluorine-containing organosulfur compound having an excellent control effect on harmful arthropods, which is represented by the formula (I): wherein m represents 0 or 1; n represents 0, 1 or 2; A represents an optionally substituted 6-membered aromatic heterocyclic group; R | 05-26-2011 |
20110136818 | THERAPEUTIC COMPOSITIONS CONTAINING MACITENTAN - The invention relates to a product containing the compound of formula (I) below or a pharmaceutically acceptable salt of this compound, in combination with at least one compound having prostacyclin receptor (IP) agonist properties, or a pharmaceutically acceptable salt thereof. | 06-09-2011 |
20110195972 | APPLICATION OF 2,5 -DIHYDROXYMETHYL -3,6 - DIMETHYL PYRAZINE AND ITS DERIVATES IN PHARMACY - An application of 2,5-dihydroxymethyl-3,6-dimethyl pyrazine and its derivatives in the preparation of drugs for the treatment of, prevention of, and/or protection from heart failure wherein the structural formula of the compound is as follows: | 08-11-2011 |
20110251204 | Modulators of G Protein-Coupled Receptor 88 - The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88. | 10-13-2011 |
20110251205 | SQUARAMIDE DERIVATIVES AS CXCR2 ANTAGONIST - The present invention relates to compounds of formula (I) | 10-13-2011 |
20110251206 | Squaramide derivatives as CXCR2 antagonist - The present invention relates to compounds of formula (I) | 10-13-2011 |
20120071485 | Therapeutic Compositions And Methods - The present invention relates in general to therapeutic compositions and methods of use. In preferred embodiments, the invention relates to the field of eye health. In some embodiments, the invention relates to the prevention and treatment of macular degeneration by administering compounds disclosed herein. In some embodiments, the invention relates to compositions and methods of improving vision. | 03-22-2012 |
20120157462 | Hydroxamic acid derivatives of aniline useful as therapeutic agents for treating anthrax poisoning - Compounds having the formula | 06-21-2012 |
20120238581 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME - Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. | 09-20-2012 |
20130005735 | ORGANIC COMPOUNDS - The present invention relates to compounds of formula (I) | 01-03-2013 |
20130137699 | THERAPEUTIC COMPOUNDS - The invention provides compounds of formula I or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for inducing apoptosis or treating cancer using compounds of formula I. | 05-30-2013 |
20140045858 | COMPOUND PREPARATION TREATING ALZHEIMER'S DISEASE AND PREPARATION METHOD THEREOF - A compound drug treating Alzheimer's disease, which is a transdermal delivery preparation mainly made by combining huperzine A and tetramethylpyrazine phosphate at a certain ratio. The compound preparation can protect the nervous system in synergy, and therefore can guard against and improve Alzheimer's disease from multiple targets. | 02-13-2014 |
20140179708 | MULTIFUNCTIONAL BIOACTIVE COMPOUNDS - The invention relates to novel multifunctional bioactive compounds, pharmaceutical compositions comprising these compounds and methods of using these compounds, in particular as therapeutic agents. | 06-26-2014 |
20140213594 | ORGANIC COMPOUNDS - The present invention relates to compounds of formula (I) | 07-31-2014 |
20140329824 | THERAPEUTIC COMPOSITIONS CONTAINING MACITENTAN - The invention relates to a product containing the compound of formula (I) below or a pharmaceutically acceptable salt of this compound, in combination of at least one compound having prostacyclin receptor (IP) agonist properties, or a pharmaceutically acceptable salt thereof | 11-06-2014 |
20140336198 | Amine Derivatives as Potassium Channel Blockers - The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation. | 11-13-2014 |
20150080408 | PYRIDINYL AMIDES AS P2X3 AND P2X2/3 INHIBITORS - Compounds of the formula I: | 03-19-2015 |
20150299184 | Amine Derivatives as Potassium Channel Blockers - The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation. | 10-22-2015 |