Class / Patent application number | Description | Number of patent applications / Date published |
436178000 | Including use of a solid sorbent, semipermeable membrane, or liquid extraction | 54 |
20090011519 | DEVICE AND METHOD FOR MICRO SORBENT EXTRACTION AND DESORPTION - This invention relates to a micro cartridge and to a method of using the micro cartridge to sample and extract components of interest from a gas or a liquid. The cartridge contains a sorbent and has passages through which a pressure drop can be created to permit access between the gas or liquid and the sorbent. The micro cartridge is elongated and has one pointed end to fit into the injection port of a suitable analysis instrument where the components of interest are desorbed. The cartridge has two ends that are covered by removable closures and preferably has a diameter of less than 1 millimeter. The cartridge can be used with micro machine components and components made using nano technology. | 01-08-2009 |
20090111193 | Sample preparation device - A sample preparation device is disclosed. The sample preparation device includes a housing defining a passage way between a first opening and a second opening; and a sample filter occupying a section of said passage way. The sample filter contains a monolith adsorbent that specifically binds to nucleic acids. Also disclosed are sample filters containing glass frit is coated with an capture agent that binds specifically to an analyte of interest, sample filters containing a hydrophilic matrix with impregnated chemicals that lyses cell membranes, a cartridge base and an integrated sample preparation cartridge. | 04-30-2009 |
20090148957 | Platelet-free analyte assay method - A novel use of serum fractionation centrifuge tubes involves placing a plasma sample in the device and centrifuging at low speed. Platelet-free plasma flows from an outer tube through a plasma permeable filter membrane and collects in the inner tube of the device. This method results in higher platelet clearance than conventional methods because it screens out platelet fragments and minimizes platelet damage. | 06-11-2009 |
20090170217 | DEVICE FOR SAMPLE PRETREATMENT, REACTOR SHEET, AND METHOD OF SAMPLE ANALYSIS - An object of the present invention is to introduce a sample solution into the minute and hydrophobic inside of a reactor for a pretreatment while avoiding bubble formation. According to the present invention, a reactor that has at least one portion having a width of 90% or less of its whole width between an inflow opening and an outflow opening is constructed on a planar substrate. | 07-02-2009 |
20090221093 | Bio-sample carrier for mass spectrometric analyses - A sample carrier has an ultraphobic surface with an affinity zone and a waste zone and/or a zone occupied by a MALDI matrix. Also disclosed is a process for isolating a substance from a mixture of substances, and for its subsequent treatment, as well as a process for purifying a substance. | 09-03-2009 |
20100047921 | METHOD FOR ISOLATION OF BIOPOLYMER BY USING RE-CIRCULATING CHROMATOGRAPHY - It is an object of the present invention to provide a method for isolating biopolymers, which is capable of simultaneously isolating many types of biopolymers from a single biological sample under the same conditions. The present invention provides a method for isolating biopolymers, which comprises repeating at least twice a process consisting of: (1) a step of preparing at least two vessels each containing a carrier retaining a substance having an affinity for a target biopolymer; then simultaneously introducing a single sample solution containing the target biopolymer into at least the two vessels, and then allowing said sample solution to come into contact with said carrier, so that the target biopolymer can be adsorbed on said carrier; (2) a step of discharging said sample solution from said vessels; and (3) a step of stirring the discharged sample solution. | 02-25-2010 |
20100081209 | PIPETTE TIPS FOR EXTRACTION, SAMPLE COLLECTION AND SAMPLE CLEANUP AND METHODS FOR THEIR USE - The present invention is a pipette tip device for extraction of liquid, semi-solid or solid solutions to be chemically analyzed and the methods for their use. The pipette tip extraction device contains a screen or filter at its lower narrow end to contain solid particulate matter and a barrier at its upper wide end. The optional upper frit is to be made of material that permits liquid solutions to flow through it. In addition to the barrier and screen, the pipette tip extraction device may contain solid-phase sorbent. Through the use of a removable cap, the pipette extraction tip may also serve as a sample collection container or tip in which samples can be delivered to the top of the tip (e.g., for direct collection of samples, including solid samples). A new method for DPX extraction using liquid-liquid-solid-phase extraction is also disclosed. | 04-01-2010 |
20100081210 | REACTION METHOD AND REACTION APPARATUS - A reaction method of performing an adsorption reaction in which a subject substance of analysis is specifically adsorbed in a first channel, the method includes: flowing a specimen liquid to a second channel connected to the first channel so that the specimen liquid is fed to the first channel, the specimen liquid containing the subject substance and a labeled substance that can be bonded to the subject substance; stopping feeding of the specimen liquid by detecting an event that a rear end of the specimen liquid flows into the first channel; joining a washing liquid to the rear end of the specimen liquid which stops in the first channel by flowing the washing liquid to a third channel that is converged to a connection portion of the second channel; and feeding the washing liquid to the first channel after the washing liquid is joined to the rear end. | 04-01-2010 |
20100120167 | Micro scale flow through sorbent plate collection device - In the invention, a collection device includes a flow through micro scale plate arranged to collect analyte. The plate includes holes, and sorbent coating on contact surfaces of the plate. The holes pass analyte fluid flow, for example analyte vapor so that fluid flow for collection may be generally perpendicular to the sorbent plate. Preferred embodiment plates include an integrated heater trace. In preferred embodiments, a high substantially perpendicular flow is used for collection and concentration, and during desorption and delivery a low substantially parallel flow is used. The low flow is selected to meet constraints of a detector system. | 05-13-2010 |
20110014722 | SPIN COLUMN SYSTEM AND METHODS - The present invention provides a low bed-volume spin column system and methods of use. The system includes various combinations of spin columns with packed beds, a rack for holding the spin columns, a receiver plate that attaches to the rack and that has wells in registration with the spin columns held in the rack, a lid that attaches to the receiver plate and seals the spin columns, and an incubator block configured for accepting the wells of the receiver plate and for incubating the packed bed. The lid, spin columns, rack, receiver plate, and incubator block are preferably capable of being assembled in a nested configuration. In preferred versions of the invention, the rack is compatible with and attachable to conventional 96-well microplates. Further provided are methods of using the spin column system that include quantitatively purifying and analyzing an analyte, removing and preventing air entrainment within the packed bed, and incubating the packed bed while preventing drying thereof. | 01-20-2011 |
20110027905 | Systems and Methods for Collection and Analysis of Analytes - Systems and methods are provided for collecting and analyzing analytes. One embodiment of the invention includes a system for collecting analyte. The system comprises a sampling section disposed on a collection platform and an air source that provides an analyte to be sorbed by the sampling section. The sampling section can be formed of a low pressure drop configuration of sorbent material | 02-03-2011 |
20110053288 | SYSTEMS AND METHODS FOR COLLECTION AND ANALYSIS OF ANALYTES - Systems and methods are provided for collecting and analyzing analytes. One embodiment of the invention includes a system for collecting analyte. The system comprises a sampling section disposed on a collection platform and an air source that provides an analyte to be sorbed by the sampling section. The sampling section can be formed of a low pressure drop configuration of sorbent material | 03-03-2011 |
20110059548 | Laser Capture Microdissection (LCM) Extraction Device and Device Carrier, and Method for Post-LCM Fluid Processing - The present invention generally discloses an extraction system that provides a locale for fluid processing and extraction on a post-microcapture transfer film. The extraction system includes a transfer film carrier and an extraction device forming a reservoir. The extraction system selectively excludes regions of the transfer film from the reservoir to advantageously reduce contamination due to matter adhered to the transfer film by non-specific transfer. | 03-10-2011 |
20110091990 | DEVICE AND METHODS FOR COLLECTION OF BIOLOGICAL FLUID SAMPLE AND TREATMENT OF SELECTED COMPONENTS - A collection device and a method for collecting a biological sample, particularly whole blood, includes a separating member to separate the whole blood into its components, and at least reagent positioned to selectively interact with a component of the separated sample. The reagent is able to selectively interact with the plasma/serum, and is prevented from contacting or interacting with the whole blood. | 04-21-2011 |
20110097816 | METHODS FOR CHANGING DENSITIES OF NON-TARGET PARTICLES OF A SUSPENSION - This disclosure is directed to methods for isolating target materials from non-target materials of a suspension that have a similar density to that of the target material. A suspension suspected of containing a target material is added to a tube and float system. A solution containing molecules that interact specifically with the non-target materials to change the density of the non-target materials in also added. A float is also added to the tube, and the tube, float, and suspension are centrifuged together. The float has a specific gravity that positions the float at approximately the same level as a layer containing the target material when the tube, float and suspension are centrifuged. During centrifugation, the non-target material/molecules complexes are drawn either below the float or above float, leaving the target material between the outer surface of the float and the inner surface of the tube. | 04-28-2011 |
20110117668 | SELF-POWERED SMART DIAGNOSTIC DEVICES - Devices and methods are provided for immobilizing a diagnostic target (e.g., indicative of a disease) from a solution (e.g., a biological fluid). The diagnostic target is first bound to a capture conjugate that includes a reversibly-associative polymer moieties attached to a first binding moiety that binds to the diagnostic target. Once the diagnostic target is bound to the capture conjugate, the solution is subjected to a change in heat and/or pH to cause the reversibly-associative polymer moieties to aggregate. The aggregates are then immobilized (e.g., via filtration). | 05-19-2011 |
20110129940 | METHOD AND APPARATUS FOR DESORPTION OF A BLOOD SAMPLE FROM A MEDICAL TEST SHEET - A method for desorption of a blood sample from a dried blood spot on a medical test sheet, for the purpose of biomedical analysis, comprises the steps of: interposing the test sheet inbetween first and second clamping heads; clamping the first and the second clamping heads onto the interposed test sheet; and flushing a desorption area of the clamped test sheet with a sample elution fluid. The clamping heads are transmitting compressive forces to parts of the test sheet. The compressive forces create an imprinted sealing area of the test sheet, which imprinted sealing area has a closed loop shape surrounding a desorption area of the test sheet. The desorption area is contained in a space enveloped by first and second outer surfaces of the first and second clamping heads, respectively, and sealed by the imprinted sealing area. | 06-02-2011 |
20110136251 | ANALYTE RECOVERY FROM DRIED BLOOD SPOTS - Pipette tips, pipetting system and methods for eluting an analyte from a solid phase filtration media that resides within an upper portion of the pipette tips. Each pipette tip includes an upper barrel containing and retaining the solid phase filtration media and a lower cannula. The solid phase filtration media resides between the upper barrel and the lower cannula. An eluting solvent is provided into the pipette tips for eluting the analyte from the solid phase filtration media by soaking, ultrasonic agitation or agitation by mixing. A sorbent material may reside within the cannula portion of each pipette tip for filtering or treating the eluted analyte containing solution prior to it being dispensed from the pipette tip into a microplate for subsequent analytical processing. | 06-09-2011 |
20110195518 | Method and Apparatus for Pipette Tip Columns - An apparatus and method of using a pipette with pipette tip columns were developed in which a pipette is operated with the pipette tip columns inserted into the wells of a microplate. In this configuration the pipette is free standing and is essentially perpendicular to the microplate. The open lower ends of the pipette tip column are approximately centered within the plate well. The columns and plate are designed in such a way that the open lower ends of the pipette tip columns are in contact with liquid in the plate well however, the columns do not seal on the well bottom, preventing flow in and out of the column. The pipette contains the appropriate firmware and software to control flow for all steps of pipette tip column operation. | 08-11-2011 |
20120028368 | SAMPLE PRETREATMENT AND EXTRACTION - A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface. | 02-02-2012 |
20120034704 | DISSOLUTION TEST EQUIPMENT - Apparatus and method for dissolution testing of active substances in various dosage forms is provided. The apparatus has filtration cells equipped and configured to simulate bodily functions, operate continuously and facilitate testing various types of dosage forms including, but not limited to, tablets, capsules and those having non-disintegrating substrates. | 02-09-2012 |
20120107951 | APPARATUS FOR PUNCHING AND SOLID PHASE EXTRACTION OF DRIED BIOLOGICAL FLUID SPOT AND RELATED METHODS - An apparatus for punching and extracting analytes from a dried biological fluid spot includes a tube and a sorbent bed. The tube includes a proximal tube opening, a distal tube opening, and a distal section. The distal section includes a tube wall having a tapered diameter that reduces down to the distal tube opening. The apparatus may also include a tube extension that includes an extension wall having a tapered diameter that reduces from a proximal extension opening to a distal extension opening. The tube extension is movable between an attached position and a detached position. At the attached position, the tube extension is secured to the tube by frictional contact between the extension wall and the tube at the distal tube opening. At the detached position the tube extension is physically separate from the tube. The sorbent bed is disposed at an axial distance from the distal tube opening and in the tube or the tube extension. The sorbent bed has a composition configured for solid phase extraction. | 05-03-2012 |
20120156799 | AUTOMATED METHOD AND SYSTEM FOR THE ANALYSIS OF TOTAL DIETARY FIBER - The invention consists of a method for determining Total Dietary Fiber (TDF) and its sub-fractions, Insoluble Dietary Fiber (IDF) and Soluble Dietary Fiber (SDF) in food and feed samples which utilizes flexible reaction/filtration containers that can be divided into one or more sections for capturing the IDF and SDF fractions separately or for capturing TDF in its entirety. Each container is fashioned as a bag that can be temporarily sealed in multiple locations to create multiple sections and is made of non-porous and porous material. Use of these containers eliminates the need for problematic transfers of mixtures from beaker to filter, and vastly improves the filtration process. | 06-21-2012 |
20120164750 | Method and Device for Sample Preparation - The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column, often between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the extraction columns are comprised of frits having a low pore volume. In some embodiments, the frits of the extraction columns have a pore volume of less than one microliter or less than 10% of the interstitial volume of the bed of extraction media. | 06-28-2012 |
20120220047 | MICROFLUIDIC SEPARATION OF PLASMA FOR COLORMETRIC ASSAY - A device includes a plasma separation membrane, a capillary channel positioned adjacent the plasma separation membrane to receive plasma from blood placed on the plasma separation membrane, at least one cuvette coupled to the capillary channel, a gas permeable membrane, and a distribution channel coupled to the capillary channel to provide plasma to the cuvette, wherein the cuvette is configured to hold an amount of plasma with reagent suitable for colorimetric assay by a tester to hold the device. Variations include the use of a quantiation channel to provide a selected amount of plasma and a mixing channel to mix plasma with a diluent. | 08-30-2012 |
20120252135 | PROTECTION FROM HYDROPHOBIZING AGENTS - The present invention concerns storage containers for storing diagnostic elements having a hydrophilic or hydrophilically coated surface. Furthermore, the invention concerns analytical measuring devices which comprise storage containers of this type, and the use of an absorption material for selectively absorbing hydrophobic, volatile substances in such storage containers. | 10-04-2012 |
20120270334 | PRECONCENTRATING A SAMPLE - A chemical analysis system is disclosed wherein, in evacuating a preconcentrator housing ( | 10-25-2012 |
20120288958 | Carbon Laminated Materials for Sample Preparation - A sample preparation material is described for supporting sample preparation procedures, such as solid phase extraction (SPE). The present sample preparation material is useful as a sorption media which is highly and selectively retentive for various analytes of interest. The sorption media is prepared by carbon deposition on target substrates, wherein the deposited carbon substantially covers the substrate. In some embodiments, the substrate may be porous particles, which retain their porosity subsequent to carbon deposition. | 11-15-2012 |
20130011931 | POLYMER INCLUDING GROUP HAVING AT LEAST TWO HYDROXYLS OR ZWITTERIONIC GROUP AND USE THEREOF - A solid support comprising a polymer that includes a group having at least two hydroxyls or a zwitterionic group and a method of using the same. | 01-10-2013 |
20130071945 | MATERIALS AND METHODS FOR CAPILLARY MICROEXTRACTION IN COMBINATION WITH HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY - Germania-based sol-gel organic-inorganic hybrid coatings were prepared for on-line coupling of capillary microextraction with high-performance liquid chromatography. A germania-based sol-gel precursor, tetra-n-butoxygermane and a hydroxy-terminated triblock copolymer, poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide), were chemically anchored to the inner walls of a fused silica capillary (0.25 mm I.D.). Scanning electron microscopy images of the sol-gel germania triblock polymer coating were obtained to estimate the coating thickness. The analyte distribution constants between a sol-gel germania organic-inorganic hybrid coating and the samples (K | 03-21-2013 |
20130130401 | Biological Sample Pretreatment Method and Apparatus - A sample treatment apparatus is disclosed that allows a filtrate after reaction to be supplied to a solid phase extraction treatment without temporary collection. A necessary amount of a solid phase extracting agent is added to a solid phase extraction device for conditioning. An aqueous solution is added to the extracting agent and supernatants are discarded. A filter device is attached to an opening of the extraction and a sample is added into a filter reservoir. A hemolyzing agent is added to the sample, and they are stirred sufficiently to cause disruption of blood cells. A protein-denaturing solution is added to the mixture, and they stirred sufficiently to denature proteins contained in the sample. They are centrifuged to leave aggregate in the filter device, and the filtrate is supplied to the solid phase extracting agent through a filter unit without collecting the filtrate. | 05-23-2013 |
20130236984 | METHOD FOR CONCENTRATION OF LOW-MOLECULAR-WEIGHT PROTEINS AND PEPTIDES IN BODY FLUID SAMPLE - (Problem to be Solved) There is to be provided a method for extracting low-molecular-weight proteins/peptides contained in a body fluid sample, particularly, in serum or plasma. | 09-12-2013 |
20130252344 | Method and Device for Sample Preparation - The invention provides pipette tip extraction columns for the purification of a DNA vector from un-clarified cell lysate containing cell debris as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the pipette tip column, above a bottom frit and with an optional top frit. | 09-26-2013 |
20140004621 | FLUID PROCESSING AND CONTROL | 01-02-2014 |
20140017805 | DEVICE AND METHOD FOR ENHANCED COLLECTION AND ASSAY OF CHEMICALS WITH HIGH SURFACE AREA CERAMIC - A method and device for enhanced capture of target analytes is disclosed. This invention relates to collection of chemicals for separations and analysis. More specifically, this invention relates to a solid phase microextraction (SPME) device having better capability for chemical collection and analysis. This includes better physical stability, capacity for chemical collection, flexible surface chemistry and high affinity for target analyte. | 01-16-2014 |
20140030818 | SOLID-PHASE MICROEXTRACTION - In a method for performing a solid-phase micro-extraction, a holding device connected to an extraction device and secured on an adapter is held, while an actuating device connected to a guide device is moved. A device for performing a solid-phase microextraction comprises an actuating device connected to a guide device, and a holding device connected to an extraction device, wherein the extraction device is guided at least partially in the guide device, and wherein the extraction device is movable relative to the guide device by means of an actuation of the actuating device. | 01-30-2014 |
20140045274 | Method for Harvesting Nanoparticles and Sequestering Biomarkers - Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid. | 02-13-2014 |
20140220701 | EXTRACTION DEVICE | 08-07-2014 |
20140242718 | PRETREATMENT DEVICE AND METHOD FOR BIOCHEMICAL REACTION - A pretreatment device applied in sampling and providing a reaction space for biochemical reaction is disclosed. The pretreatment device includes a quantitative sampler being capable of collecting a constant volume of a sample; a devastating device having a hollow cylindrical structure coupled to the quantitative sampler to damage a thin-film like protective membrane of the quantitative sampler such that the reaction reagent flows out of the reagent container; a reaction device having a tubular structure and providing the reaction space for biochemical reaction of the reaction reagent and the sample; a hollow ring-shaped structure to position and stable the connection of the devastating device and the quantitative sampler with the hollow ring-shaped structure being coupled to the reaction device; and an anti-drain device preventing the reaction reagent and the sampler from flowing out before the biochemical reaction is completed. | 08-28-2014 |
20140302617 | SAMPLE COLLECTION SYSTEM AND METHOD FOR USE THEREOF - A sample collection system capable of collecting, storing and dispensing a liquid sample is disclosed. The collection system includes a collector composed of a material which has the unique ability to express constituents of interest at levels which are much more concentrated than their levels in the fluid samples from which they are expressed, where the expressed highly concentrated sample can then be used with modern rapid screening/testing protocols, such as solid phase assays, to test for the constituents of interest. Thus, it is now possible to obtain analytes of interest, such as the HIV protein antibodies, from saliva samples at concentrations that are detectable with systems and/or devices that are typically utilized only for blood serum or plasma testing. The collector is sized and shaped to fit within a recovery container, which, in turn, is sized and shaped to fit within a collection tube. The recovery container includes an aperture which does not permit passage of fluid under ambient conditions, but facilitates transfer thereof when subjected to pressure. An optional channel within the collection tube facilitates dispensing of the sample for further processing. | 10-09-2014 |
20140356976 | Sorptive Extraction Layer for Immobilized Liquid Extraction - A sorptive extraction layer for immobilized liquid extraction of target molecules preferably from biological samples is disclosed. The sorptive extraction layer is mainly composed of ethylene-acrylate-copolymer. Preferably, microplate wells are at least partially coated with such a sorptive extraction layer. There is also disclosed a method of extracting target molecules preferably from biological samples. According to this method, immobilized liquid extraction is carried out with a sorptive extraction layer which is mainly composed of ethylene-acrylate-copolymer. | 12-04-2014 |
20140363897 | METHODS TO ACCELERATE THE BINDING OF BIOLOGICAL MOLECULES - A method is provided for enhancing the binding of reagents to ligands. In the method a ligand is immobilized on a porous support and incubated with a reagent solution. The binding of the reagent to the ligand is increased by a cycling process of passing the reagent solution through the support multiple times. A device that facilitates the cycling process is disclosed. The invention also provides a method to detect multiple ligands using the cycling process. | 12-11-2014 |
20150024511 | FUNCTIONALIZED LIPID MODIFICATION OF SOLID PHASE SURFACES FOR USE IN CHROMATOGRAPHY - A solid phase for use in separation has been modified using an aqueous phase adsorption of a headgroup-modified lipid to generate analyte specific surfaces for use as a stationary phase in separations such as high performance liquid chromatography (HPLC) or solid phase extraction (SPE). The aliphatic moiety of the lipid adsorbs strongly to a hydrophobic solid surface, with the hydrophilic and active headgroups orienting themselves toward the more polar mobile phase, thus allowing for interactions with the desired solutes. The surface modification approach is generally applicable to a diversity of selective immobilization applications such as protein immobilization clinical diagnostics and preparative scale HPLC as demonstrated on capillary-channeled fibers, though the general methodology could be implemented on any hydrophobic solid support material. | 01-22-2015 |
20150037903 | DEVICE AND METHOD FOR DRIED FLUID SPOT ANALYSIS - A lab-on-chip-based system is described for the direct and multiple sampling, control of the volume, fluid filtration, biochemical reactions, sample transfer, and dried spot generation on the conventional and commercial cards for dried fluid spot. Within an all-in-one integrated holder, the invention allows the complete process required to ensure a quantitative analysis of blood, plasma or any other fluids, modification and enrichment of molecule subsets, and formation of a dried fluid spot on the specific spot location of a passive cellulose, non-cellulose, absorbent, or non-absorbent membrane material sampling. | 02-05-2015 |
20150314291 | METHOD FOR SEPARATING NANOPARTICLES AND ANALYZING BIOLOGICAL SUBSTANCE USING MICROFLUIDIC CHIP - The present invention relates to a method for separating nanoparticles and analyzing a biological substance using a microfluidic chip. The microfluidic chip of the present invention is effective in more sensitively and precisely detecting an analyte. According to the present invention, the use of the microfluidic chip enables the separation of nanoparticles through separation holes on the basis of size, achieving highly reliable analysis of a biological substance. In conclusion, the microfluidic chip of the present invention uses separation holes adapted to the size of nanoparticles to greatly increase the reliability of analysis of a biological substance, which will contribute to a marked improvement in the reliability of analysis based on microfluidics and a microfluidic system. | 11-05-2015 |
20150338319 | SYSTEM AND METHOD FOR TRACE SAMPLE PRECOLLECTION AND PRECONCENTRATION - A device and procedure are described that can be used for improved sampling of traces such as for explosive trace screening, by precollection and preconcentration of trace samples of vapor and particulate matter from air. The device is unique in its ability to collect both solid and vapor traces. | 11-26-2015 |
20150377753 | CAPTURING PARTICLES - Methods and systems capturing particles suspended in a fluid flowed through a micro-channel, can include flowing the fluid including the particles to be captured through a micro-channel and past a groove defined in a surface of a wall of the micro-channel such that flowing the fluid past the groove forms microvortices in the fluid; contacting at least some of the particles against an adherent disposed on one or more of walls of the microchannel after the microvortices form in the fluid; and capturing at least some of the particles contacting the adherent. | 12-31-2015 |
20160061801 | DISSOLUTION TEST EQUIPMENT - Apparatus and method for dissolution testing of active substances in various dosage forms is provided. The apparatus has filtration cells equipped and configured to simulate bodily functions, operate continuously and facilitate testing various types of dosage forms including, but not limited to, tablets, capsules and those having non-disintegrating substrates. | 03-03-2016 |
20160097700 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers. | 04-07-2016 |
20160103045 | All-In-One Sample Preparation Device And Method - Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed. | 04-14-2016 |
20160139014 | NANOMETER SIZE CHEMICAL MODIFIED MATERIALS AND USES - Ligand compositions and stationary phases comprising polyhedral oligomeric silsesquioxane moieties are incorporated in to chromatographic stationary phases, and these phases are incorporated into chromatography devices, such as columns. The compositions and devices are of use to separate molecular mixtures. | 05-19-2016 |
20160158728 | MODIFIED DIAMOND PARTICLES - Modified diamond particles for use in chromatography with a desired functional group at the diamond surface, formed from reaction of hydroxyl groups at diamond surfaces with a reactive molecule. | 06-09-2016 |
20160160209 | SEQUENTIAL DELIVERY DEVICE AND METHOD - A reagent delivery method includes placing a reagent delivery column including a plurality of reagent storage elements therein in a centrifugal device, coupling a breaching element to the housing, and rotating the centrifugal device to force the reagent storage elements toward the breaching element, breaching of the reagent storage elements releasing reagent therein and communicating the same to an external environment. A reagent delivery system includes a column having a housing, a plurality of reagent storage element sheets positioned in the housing or forming a stack, a plurality of breaching elements, and a microplate having a plurality of wells, the microplate coupled to the housing where each well corresponds or aligns with a breaching element and a reagent storage element. The system can be rotated in a centrifugal device to force the reagent storage element stacks toward the breaching elements. | 06-09-2016 |
20160187306 | VIAL CAP AND METHOD FOR REMOVING MATRIX COMPONENTS FROM A LIQUID SAMPLE - A vial cap for removing a matrix component from a liquid sample is described. The vial cap includes a cap body, an inlet portion, and an outlet portion. The cap body is configured to have a slidable gas and liquid seal with a side wall of a sample vial. The inlet portion includes a counterbore section that holds a filter plug. The filter plug includes a polyethylene resin and a material selected from the group consisting of an ion exchange material and a reversed-phase material. The vial cap is adapted for solid phase extraction for use in an autosampler with a plurality of sample vials. | 06-30-2016 |