Class / Patent application number | Description | Number of patent applications / Date published |
436161000 | INCLUDING CHROMATOGRAPHY | 41 |
20080274561 | METHOD AND APPARATUS FOR DETERMINING A TOTAL CONCENTRATION OF A COMPONENT IN A MIXTURE OF COMPONENTS - The invention relates to a method and apparatus for determining a total concentration of a component in a sample, including a reactor for oxidizing or reducing the sample, a chromatographic column coupled to the reactor for separating the component in the sample, and an electrochemical gas sensor coupled to the chromatographic column for detecting the component. In further embodiments, a filter may be used instead of or in addition to the column. Moreover, multiple sensors may be used instead of or in addition to the column for simultaneously detecting multiple components. | 11-06-2008 |
20080299671 | Hydrophobic Interaction Chromatography - The present invention relates to a method of isolating target compounds from a liquid, which method including the steps of providing a mobile phase, which contains at least one target compound and wherein the conductivity corresponds to ≧0.6 M; contacting the mobile phase with a separation matrix including one or more sulphonamide groups to adsorb one or more target compounds; contacting an eluent with the matrix to release target compound(s), wherein the conductivity of the eluent is reduced as compared to the mobile phase conductivity and the pH is substantially equivalent to the mobile phase pH; and, optionally, recovering at least one target compound or a purified liquid. | 12-04-2008 |
20080299672 | System And Method For Testing Chromatography Media And Devices - Methods for testing the chromatography type and/or the integrity of a chromatography membrane or monolith, preferably, for testing the chromatography type and integrity of a chromatography device comprising a chromatography membrane or chromatography monolith while the membrane or monolith is sealed in a housing, are disclosed. | 12-04-2008 |
20080311672 | Membrane based concentrators - A sample concentrator for concentrating analytes in a solvent-containing liquid sample stream, including concentrator housing having a sample stream flow channel and a gas stream flow channel having an inlet and an outlet, a heater for gas in the gas stream conduit, and a hydrophilic ion exchange or non-ionic membrane barrier separating said gas stream flow channel and said sample stream flow channel. Solvent is evaporated from the liquid sample stream in said sample stream flow channel in or at the interface with said membrane, when the gas stream is at an elevated temperature. A regeneration step is used to regenerate the ion exchange membrane barrier. | 12-18-2008 |
20080318334 | Microfluidic devices comprising fluid flow paths having a monolithic chromatographic material - Aspects of the invention include a microfluidic device having a fluid flow path and a monolithic chromatographic material covalently bound to at least a portion of a polymeric surface of the fluid flow path. Aspects of the invention further include methods of making and using such devices. | 12-25-2008 |
20090075390 | LIQUID CONTAINMENT FOR INTEGRATED ASSAYS - Microfluidic systems including liquid containment regions and methods associated therewith for performing chemical, biological, or biochemical analyses are provided. Liquid containment regions of a microfluidic device may include regions that capture one or more liquids flowing in the device, while allowing gases or other fluids in the device to pass through the region. This may be achieved, in some embodiments, by positioning one or more absorbent materials in the liquid containment region for absorbing the liquids. This configuration may be useful for removing air bubbles from a stream of fluid and/or for separating hydrophobic liquids from hydrophilic liquids. In certain embodiments, the liquid containment region prevents any liquid from passing through the region. In some such cases, the liquid containment region may act as a waste area by capturing substantially all of the liquid in the device, thereby preventing any liquid from exiting the device. This arrangement may be useful when the device is used as a diagnostic tool, as the liquid containment region may prevent a user from being exposed to potentially-harmful fluids in the device. | 03-19-2009 |
20090081805 | Method for finding active ingredients from chemical and biological systems - The present invention relates to a method for finding active ingredients/groups of constitutes from a multi-component system that are active as indicated by specific or a group of activity test. The method involves the use of a hyphenated instrument for determining the active ingredients. | 03-26-2009 |
20090104709 | FLUID TRANSFER DEVICES - A fluid transfer device includes a body and a sample holding reservoir formed in the body. The sample holding reservoir is capable of imbibing a fixed and very small quantity of fluid from a fluid source and dispensing the fixed quantity of fluid therefrom at a destination. The fluid transfer device may be manufactured from various materials including semiconductor materials such as silicon, polymer materials, ceramic material, and metal or metallic materials. The fluid transfer device may be used to puncture a closure covering the fluid source or the destination. | 04-23-2009 |
20090298189 | Hydrophobic Ionic Liquids - The subject of the invention at hand are novel, a little basic, fluorinated pentafluorophenyl imide anions, which can be used as anions in ionic liquids. Methods for producing ionic liquids are described, which contain these novel pentafluorophenyl imide ions as anions, as well as quaternary organic ammonium ions, guanidinium ions, N-organo-pyridinium ions, imidazolium, imidazolidinium or benzimidazolidinium ions, alkyl-alkylidene phosphoranes or aryl-alkylidene phosphoranes as cations. Alternative methods according to the present invention provide ionic liquids through reaction of ketene N,N-diacetals or alkyl or aryl-alkylidene phosphoranes with acids. | 12-03-2009 |
20100144051 | LARGE CAPACITY ACID OR BASE GENERATOR AND METHOD OF USE - Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin. | 06-10-2010 |
20100311180 | PROCESS FOR PREPARATION OF LABISIA PUMILA EXTRACT - A process for the preparation of | 12-09-2010 |
20100330689 | HYDROPHILIC POLYMER MICROPARTICLE, FILLER FOR ION EXCHANGE LIQUID CHROMATOGRAPHY, AND METHOD FOR PRODUCTION OF FILLER FOR ION EXCHANGE LIQUID CHROMATOGRAPHY - An object of the present invention is to provide a hydrophilic polymer microparticle which shows reduced swelling in an aqueous medium and has an excellent dispersibility in an aqueous medium, a filler for ion-exchange liquid chromatography which can effectively suppress non-specific adsorption of protein and the like, a method for analyzing glycosylated hemoglobin using the filler for ion-exchange liquid chromatography, a method for production of a filler for ion-exchange liquid chromatography that can maintain suppressive effects on swelling, non-specific adsorption and the like for a long period of time, a filler for ion-exchange liquid chromatography produced by the method for production of a filler for ion-exchange liquid chromatography, and a filler for ion-exchange liquid chromatography for glycosylated hemoglobin analysis. | 12-30-2010 |
20110086430 | METHOD AND DEVICE FOR ISOTOPIC RATIO ANALYSIS - A process and an apparatus for isotope ratio analysis, the process having the following steps: performing a liquid chromatography process and thus providing an eluate which comprises at least one liquid carrier fluid and at least one analytes, collecting a portion of interest from the eluate, processing the eluate portion to form at least one gaseous conversion products of the analytes, and supplying the gaseous conversion products, especially with gaseous carrier fluid, to an isotope analyzer and determining the isotrope ratios. | 04-14-2011 |
20110091984 | ANALYTICAL METHOD TO MONITOR VACCINE POTENCY AND STABILITY - The present invention is directed to methods of evaluating whether an antigen or vaccine has degraded over time using liquid chromatography. The methods described herein also relate to using liquid chromatography to evaluate the relative potency of a given antigen or vaccine. | 04-21-2011 |
20110097813 | THREE-DIMENSIONAL LIQUID CHROMATOGRAPHY - In a liquid chromatography apparatus, a separation column of intermediate stage is additionally connected between a separation column of first stage and a separation column of second stage. Preferably, a switching unit and a liquid feed unit for mixing and feeding a plurality of solutions are added to improve a separation capability. A three-dimensional liquid chromatography apparatus capable of avoiding the “solution interference” can be realized. Even a complex sample containing a hydrophilic component and a hydrophobic component in a mixed state can be separated and analyzed satisfactorily on-line. | 04-28-2011 |
20110189784 | Immunochromatography Detection Sensor Comprising Optical Waveguide and a Detection Method Using the Same - The present invention relates to an immunochromatographic detection sensor comprising optical waveguides and a detection method using the same, and more particularly, to an immunochromatographic detection sensor comprising optical waveguides, in which the optical waveguides are provided under the membrane, probe beams transmitted through the optical waveguide maximize the interaction frequency between evanescent wave generated on the surface of optical waveguide and the colored conjugate in the band formed on the membrane, and thus the absorbance signal from the colored conjugate is greatly amplified to improve the sample detection sensitivity, and a detection method using the same. | 08-04-2011 |
20110212536 | METHOD AND APPARATUS FOR THE ISOTOPE-RATIO ANALYSIS - A process and to an apparatus for isotope ratio analysis having the steps of: performing an LC process and thus providing a first eluate which comprises at least one first liquid carrier fluid and one or more analytes, collecting a portion of interest from the eluate, processing the eluate portion of interest by combining with a second liquid carrier fluid and removing the first carrier fluid to form a processed eluate portion, processing the processed eluate portion to form one or more gaseous conversion products of the analytes, and supplying the gaseous conversion products with gaseous carrier fluid to an isotope analyzer and determining the isotope ratios. | 09-01-2011 |
20110229977 | CHROMATOGRAPHIC ANALYSIS APPARATUS AND METHOD, AS WELL AS PROGRAM - Testing of a test article based on a color development state of a test area is achieved in an easy manner. A sample is deposited on a spreading layer of a test piece, and the test piece is loaded in a loading port of a chromatographic analysis apparatus. After a preset time has elapsed, color development states of the test area and a control area in an observation window are read as an image. A preprocessing unit applies preprocessing to the image, and then, spatial frequency components of the image are calculated. Then, pattern information is generated based on the spatial frequency components, and the pattern information is displayed on an information output unit. | 09-22-2011 |
20120015443 | NOVEL CHIRAL SELECTORS AND STATIONARY PHASES FOR SEPARATING ENANTIOMER MIXTURES - Chiral selectors having α-unsubstituted β-amino acid derivatives of the structure: | 01-19-2012 |
20120058568 | LIQUID CHROMATOGRAPH AND ANALYSIS METHOD - It is an object of the present invention to provide a liquid chromatograph which, in a high performance liquid chromatograph analysis using a post-column method, can maintain mixing precision of a sample eluted from a column and a reaction reagent without a special mixing and reacting portion, prevent diffusion of a target component, and perform measurement with high sensitivity. | 03-08-2012 |
20120135534 | ADSORPTION TEST METHOD OF SPHERICAL CARBON ADSORBENT - The present invention relates to an adsorption test method of a spherical carbon adsorbent, particularly Kremezin, which includes evaluating a test solution containing one or more kinds of particular uremic toxins or related compounds for the adsorbability, namely, adsorption titer, adsorption speed and/or adsorption selectivity, of the spherical carbon adsorbent. | 05-31-2012 |
20120142118 | MICROFABRICATION OF HIGH TEMPERATURE MICROREACTORS - Microreactors, methods of fabricating, and using such microreactors comprises a substrate having an outer periphery and composing two monolithic sections, each of said monolithic sections comprising two opposed main surfaces and one or more edges extending between the main opposed surfaces. One of the main surfaces from each of the monolithic sections are joined together at a substantially planar junction. The microreactor further comprises at least one microcapillary flow passage defined by surfaces within said substrate and having first and second ends. One or more inlets connect the outer periphery of said substrate with the first end of said microcapillary flow passage. One or more outlets connect the outer periphery of said substrate with the second end of said microcapillary flow passage, which may narrowingly taper. The substrate can be made from high purity fused silica. A metallic reagent and/or catalyst can be incorporated in the micro capillary passage. | 06-07-2012 |
20120164744 | Flow Control in Multidimensional Chromatography - A method of carrying out three-dimensional chromatography, wherein a mobile phase passes through a separation body, the flow of the mobile phase being controlled in terms of space and/or time by locally influencing the chemical and/or physical properties of the separation body. | 06-28-2012 |
20120184046 | SELECTIVE BOND REDUCTION IN MICROFLUIDIC DEVICES - The invention overcomes the limitations described for the bonding of structured layers by providing a method for selectively reducing the bonding of materials. In its most generic form, the invention uses a bonding technique in combination with a printing method for modifying or covering at least one portion of a surface to either fully or partially prevent localised bonding. The structuring process may act upon the layers either before or after the bonding of the layers. The invention overcomes the limitations described in the application of affinity chromatography by providing a planar substrate with discrete optical detection flow cells that contain porous material and have connecting microchannels for fluid delivery and/or removal, and a method for making the same. | 07-19-2012 |
20120190122 | Low volume liquid specimen apportionment device and method - A liquid specimen collecting and testing device has two chambers, a first for collecting a liquid specimen and a second for exposing a measured volume preliminary screening aliquot of the specimen to preliminary screening test strips. The first chamber has a catch basin of defined volume which is less than the sample volume. The basin is simultaneously sealed from the rest of the first chamber, thus separating and apportioning the measured volume preliminary screening aliquot from the collected volume. Simultaneously, an opening made leading from the basin to the second chamber initiating the preliminary screening test. Thus intermingling of a preliminary screening aliquot and a remainder aliquot is avoided. | 07-26-2012 |
20130115709 | CHROMATOGRAPHY METHOD AND MEDIA USED THEREFORE - The present invention relates to a method for running ion exchange chromatography on a media comprising shell beads having an inner porous core and an outer shell, wherein the inner core is provided with ligands whose charge changes with pH and the shell is provided with charged ion exchange ligands, the method comprising the following steps: a) adsorbing sample molecules on the shell ligands at a first pH; b) causing a discharge of the inner core ligands at a second pH by addition of a buffer substance that is able to increase its charge having the same sign/type as that of the core ligands, which at the same time causes release of ions from the inner core ligands and thereby an increase in ionic strength that displaces the sample molecules from the shell ligands i.e. causes an elution. | 05-09-2013 |
20130309777 | SURROGATE ADDITION DEVICE AND A METHOD OF ANALYTE CONCENTRATION - A surrogate addition device is described that adds a surrogate compound at a uniform transport rate to a flowing sample stream. The surrogate addition device includes a surrogate reservoir, a flow chamber, and a diffusion barrier. The surrogate reservoir can be configured to contain a surrogate solution where the surrogate solution includes a surrogate compound. The flow chamber includes an inlet port and an outlet port. At least a portion of the diffusion barrier is disposed in between the surrogate reservoir and the flow chamber. The diffusion barrier may include an inner surface that forms a wall of the surrogate reservoir, and an outer surface that forms a wall of the flow chamber. The flow chamber can be configured to receive a flowing sample solution across the outer surface of the diffusion barrier and also to diffuse the surrogate compound from the surrogate reservoir to the flow chamber. | 11-21-2013 |
20130316466 | SAMPLE PRETREATMENT AND EXTRACTION - A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface. | 11-28-2013 |
20140179018 | METHOD FOR ANALYZING HALOGEN OXOACIDS - To quantitatively analyze halogen oxoacids such as bromic acid and perchloric acid, an HPLC/MS in which a mass spectrometer is connected to the outlet of a column of a high performance liquid chromatograph (HPLC) is used, and by using a reverse-phase column having an ion exchange function as the column, as well as a mixed liquid of an ammonium formate buffer solution and acetonitrile as the mobile phase, gradient analysis in which the concentration of ammonium formate in ammonium formate/acetonitrile is increased is performed. Thereby, a common HPLC/MS apparatus configuration using no suppressor makes it possible to appropriately separate various halogen oxoacids and other components contained in a sample and to detect them at high sensitivity. | 06-26-2014 |
20140273264 | EPOXY CHEMISTRY DERIVED MATERIALS AS MIXED MODE CHROMATOGRAPHY MEDIA, METHOD FOR THEIR SYNTHESIS AND USE - This invention provides mixed-mode stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separations. | 09-18-2014 |
20140315324 | DEVICE, METHOD AND APPARATUS FOR THE TRANSFER OF ANALYTES - According to the present invention, there is provided a device for transferring an analyte from a reaction chamber to a detector, which detector is capable of detecting said analyte. The device comprises a tubular member having a first end adapted to receive a sample containing said analyte within said reaction chamber and a second end adapted to communicate with a sample inlet of said detector; and a jacket for regulating the temperature of sample passing through the tubular member, wherein said jacket is disposed about at least a portion of the tubular member. Methods of using the device, and apparatus comprising the device, are also provided. The device may be used to transfer an analyte from a reaction chamber to a detector during the course of a chemical reaction, such that the reaction can be monitored in situ. | 10-23-2014 |
20140370614 | HILIC / ANION-EXCHANGE / CATION-EXCHANGE MULTIMODAL MEDIA - The present invention provides an agglomerated multimodal chromatographic medium. the medium of the invention includes groups active in anion exchange, cation exchange and hydrophilic interaction chromatographic modalities. The invention provides methods of making these media and using them in separations of analytes. Also provided are separations devices incorporating the medium and systems incorporating these separations devices. | 12-18-2014 |
20140377878 | VIAL RACK FOR LIQUID CHROMATOGRAPHY HAVING DRAINING MEANS - The present invention provides a rack for holding sample vials comprising: (i) a solid base; (ii) an upwardly extending wall around the perimeter of said base; (iii) a plurality of means for supporting a plurality of vials, each means for supporting one vial; and (iv) a means for draining liquid from said rack. | 12-25-2014 |
20150079692 | METHOD OF DETERMINING PHENOXY HERBICIDES IN WATER SAMPLES BY PHASE TRANSFER MICROEXTRACTION WITH SIMULTANEOUS DERIVATIZATION AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY ANALYSIS - A method for determining the concentration of a phenoxy herbicide in an aqueous sample, by simultaneously phase-transfer catalyst extracting and alkylating an aqueous sample comprising a phenoxy herbicide to form a sample composition, and measuring an amount of the alkylated phenoxy herbicide in the sample composition. The method includes controlling factors such as pH of the aqueous matrix, temperature, extraction duration, type and amount of derivation reagents, and type and amount of phase transfer catalyst. | 03-19-2015 |
20150111305 | MULTIELECTRODE ELECTROLYTIC DEVICE AND METHOD - An electrolytic device comprising: a central sample flow channel, first and second regenerant flow channels, first and second charged barriers disposed between said sample flow channel and first and second regenerant flow channels, and pairs of oppositely charged, spaced electrodes disposed in the regenerant flow channels. Also, electrolytic devices with a different electrode configuration are described. Also, methods of using the devices, e.g., for suppression in an ion chromatography system are described. | 04-23-2015 |
20170234782 | ANALYTE CONCENTRATOR SYSTEM AND METHODS OF USE | 08-17-2017 |
20170234852 | BIOMARKER COMPOSITIONS SPECIFIC TO CORONARY HEART DISEASE PATIENTS AND USES THEREOF | 08-17-2017 |
436162000 | Utilizing paper or thin layer plate | 4 |
20090221085 | Thin-Layer Chromatography and Colorimetric Analysis of Multi-Component Explosive Mixtures - A thin-layer chromatography method for detection and identification of common military and peroxide explosives in samples includes the steps of provide a reverse-phase thin-layer chromatography plate; prepare the plate by marking spots on which to deposit the samples by touching the plate with a marker; spot one micro liter of a first standard onto one of the spots, spot one micro liter of a second standard onto another of the spots, and spot samples onto other of spots producing a spotted plate; add eluent to a developing chamber; add the spotted plate to the developing chamber; remove the spotted plate from the developing chamber producing a developed plate; place the developed plate in an ultraviolet light box; add a visualization agent to a dip tank; dip the developed plate in the dip tank and remove the developed plate quickly; and detect explosives by viewing said developed plate. | 09-03-2009 |
20090253213 | DEVICE AND PROCESS FOR THE CHROMATOGRAPHIC DETECTION OF A SUBSTANCE - A device for the chromatographic detection of a substance provides an improved reproducible measuring process. A monitoring indicator ( | 10-08-2009 |
20120149124 | DEVICE FOR COLLECTION AND ASSAY OF ORAL FLUIDS - A method and a device for collection and assay of oral fluids are disclosed. The method places an assay device into an oral cavity, removes the device, and determines the presence or absence of an analyte. The assay device comprises an assay portion housing a lateral flow assay strip, a neck portion extending from the assay portion and forming a channel for fluid delivery to the assay strip; a collection strip in fluid communication with the lateral flow assay strip; and a blocking strip coupled between and in flow communication with the lateral flow assay strip and the collection strip. The channel is defined by a narrow part proximal to the assay portion and a part which receives oral fluid and has a substantially wider channel width. The collection strip has a first portion disposed within the channel and a second portion protruding outwardly from the neck opening. | 06-14-2012 |
20160077068 | THIN-LAYER CHROMATOGRAPHY PLATE, METHOD FOR PRODUCING SUCH A PLATE, AND METHOD FOR PERFORMING A THIN-LAYER CHROMATOGRAPHY SEPARATION - The present invention relates to a thin-layer chromatography plate at least consisting of a support and a sorbent layer, where the sorbent layer comprises at least one siloxane oligomer, to a process for the production thereof, and to a method for carrying out a thin-layer chromatographic separation using said thin-layer chromatography plate. | 03-17-2016 |