| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435371000 | Epithelial origin or derivative | 17 |
| 20110300627 | DEDIFFERENTIATION AND REPROGRAMMING OF CELLS - The invention is directed to methods for reprogramming somatic cells to a less differentiated state. In particular, the invention is directed to methods for reprogramming amnion epithelial cells (AEC) including amnion-derived cells (ADC) and Amnion-derived Multipotent Progenitor cells (AMP cells) to a less differentiated state. The invention is further directed to compositions comprising reprogrammed AEC, ADC and AMP cells, and uses thereof. | 12-08-2011 |
| 20140256037 | CULTURE MEDIUM FOR EPITHELIAL STEM CELLS AND ORGANOIDS COMPRISING THE STEM CELLS - The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising said epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem cells and isolated tissue fragments. The invention further relates to a cell culture medium comprising a BMP inhibitor, a mitogenic growth factor, and a Wnt agonist, to the use of said culture medium, and to crypt-villus organoids, gastric organoids and pancreatic organoids that are formed in said culture medium. | 09-11-2014 |
| 20100047907 | METHODS OF TRANSPORTING EPITHELIAL CELL MONOLAYERS - Described herein are tissue culture plates with permeable tissue culture plate inserts therein, which provides the tissue culture plates with apical chamber and a basolateral chambers, wherein cells are deposited on the permeable tissue culture inserts and essentially all of tissue culture medium has been removed from the apical chambers of the tissue culture plates and the basolateral chambers of the tissue culture plates contain a solidifiable form of cell culture medium. Also described are cells that can be deposited and grown on the described tissue culture inserts, methods for transporting a tissue culture plate with a permeable tissue culture plate insert therein on which cells are deposited. Also described is a kit for transporting the tissue culture plates described above, and corresponding methods of use. | 02-25-2010 |
| 20100323440 | PROCESS FOR STERILIZING ACELLULAR SOFT TISSUE UNDER PRESSURE - The present invention relates to a process for preparing skin removed from a human donor, removal of cellular components and sterilizing the decellularized skin. The process comprises the following steps:
| 12-23-2010 |
| 20100291677 | REDUCER OF IMMUNOSUPPRESSION BY TUMOR CELL AND ANTITUMOR AGENT USING THE SAME - In order to provide a gene expression enhancer for enhancing expression of FoxP3 gene in a cell; a cell differentiation inducer for inducing differentiation of a cell into a regulatory T cell; an immunosuppressor for suppressing immunity and an agent for treating hyperimmune diseases based on the abovementioned actions; an inhibitor of enhancement of gene expression for inhibiting enhancement of expression of FoxP3 gene in a cell; an inhibitor of induction of cell differentiation for inhibiting induction of differentiation of a cell into a regulatory T cell; a reducer of immunosuppression for reducing immunosuppression, a stimulator of tumor immunity and an antitumor agent based on the abovementioned actions; and the like, for example, an agent containing at least one of a cell expressing Snail protein, MCP1 protein, FSTL1 protein, membrane IL-13Ra2 protein or secretory IL-13Ra2 protein, or MCP1 protein, FSTL1 protein or secretory IL-13Ra2 protein, is used as a gene expression enhancer for FoxP3, an inducer of regulatory T cell differentiation, an immunosuppressor or an agent for treating hyperimmune diseases; and an agent containing an anti-MCP1 antibody, an anti-FSTL1 antibody or an anti-IL-13Ra2 antibody is used as an inhibitor of enhancement of FoxP3 gene expression, a reducer of immunosuppression, a stimulator of tumor immunity, an antitumor agent, or the like. | 11-18-2010 |
| 20100022000 | Increasing Cell Culture Population Doublings for Long-Term Growth of Finite Life Span Human Cell Cultures - Cell culture media formulations for culturing human epithelial cells are herein described. Also described are methods of increasing population doublings in a cell culture of finite life span human epithelial cells and prolonging the life span of human cell cultures. Using the cell culture media disclosed alone and in combination with addition to the cell culture of a compound associated with anti-stress activity achieves extended growth of pre-stasis cells and increased population doublings and life span in human epithelial cell cultures. | 01-28-2010 |
| 20130316452 | Modalities for the treatment of degenerative diseases of the retina - This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells. | 11-28-2013 |
| 20130059378 | HUMAN EPIDERMIS-DERIVED MESENCHYMAL STEM CELL-LIKE PLURIPOTENT CELLS AND PREPARATION METHOD THEREOF - The invention discloses a cell culture medium, human epidermis-derived mesenchymal stem cell-like pluripotent cells and a preparation method thereof. The culture medium is formed by adding fetal bovine serum, hbFGF, hSCF, non-essential amino acids, L-glutamine and gentamicin into a DMEM culture medium with the glucose content of 0.5-5 g/L, wherein every 100 mL of the final culture medium contains 10-25% by volume percent of fetal bovine serum, 100-4000 ng of the hbFGF, 10-2000 ng of hSCF, 0.1-2 mL of 100× non-essential amino acids, 0.1-2 mL of PBS solution containing 3% by mass percent of L-glutamine and 1000-8000 U of gentamicin. A human epidermis-derived mesenchymal stem cell-like pluripotent cell strain is prepared by culturing human epidermal cells in the culture medium, digesting with digestive juice, removing undigested human epidermal cells, collecting digested mesenchymal stem cell-like cells and performing in-vitro culture and passage. | 03-07-2013 |
| 20140093958 | HYDROGEL COMPOSITION AND USES THEREOF - Hydrogel composition comprising gelatin, poly-glutamic acid and epiregulin suitable for cultivating keratinocytes, preferably human keratinocytes. | 04-03-2014 |
| 20120122213 | METHOD FOR CULTURING STEM CELLS - In the field of biological technology, a stem cell culture method is provided. The method includes preparing an amniotic epithelial cell feeder layer that is not treated to lose the division ability; and seeding the stem cells onto the amniotic epithelial cell feeder layer, and culturing in a culture medium. The stem cell culture method according to the present invention does not require the treatment of the feeder layer cells to lose the division ability, and is thus simple and safe, thereby effectively solving the problem of contamination caused by animal-derived ingredients in culture of human stem cells at present, greatly reducing the culture cost of the stem cells, and providing a safe, effective, and inexpensive stem cell culture method for the industrialization of the stem cells in the future. | 05-17-2012 |
| 20120122212 | TGF-BETA PATHWAY INHIBITORS FOR ENHANCEMENT OF CELLULAR REPROGRAMMING OF HUMAN CELLS - The present disclosure provides methods and compositions to enhance reprogramming in human cells. In some cases, the method includes contacting human cells with an inhibitor of the TGFβ pathway, for example a TGFβ receptor (TGFβR) inhibitor in combination with one or more induction factors. | 05-17-2012 |
| 20110300628 | ENHANCEMENT OF EPIDERMAL CELL GROWTH BY NON-PROTEIN GROWTH FACTORS - The serum-free culture of normal human epithelial stem cells is of paramount importance for the in vitro formation of cloned human tissues by means of cell therapy. Several growth promoting agents are disclosed for use in a serum-free culture medium of normal human keratinocytes. Lithium ions, dibutryl-cyclic adenosine monophosphate, and prostaglandin E1 have been found effective as growth enhancing agents to be added singly or in combination, when used in combination with insulin-like growth factor-1. Lithium ions and prostaglandin E1 are disclosed as independent growth enhancing factors, that replace epidermal growth factor as a necessary growth factor required for keratinocyte clonal growth. | 12-08-2011 |
| 20160008408 | METHOD FOR PRODUCING HUMAN CORNEAL EPITHELIUM SHEET | 01-14-2016 |
| 20120315700 | IN VITRO TUMOR ANGIOGENESIS MODEL - Provided is a method of inducing tubulogenesis in normal endothelial cells comprising co-culturing the normal endothelial cells with tumor cells and forming tubules from the normal endothelial cells. | 12-13-2012 |
| 20120190109 | Process for Obtaining Myofibroblasts - The invention relates to a process for obtention of myofibroblasts. According to this process:
| 07-26-2012 |
| 20120238016 | Specific nNOS Inhibitors for the Therapy And Prevention Of Human Melanoma - Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies. | 09-20-2012 |
| 20090186407 | Alternative Compositions and Methods for the Culture of Stem Cells - Methods and cell culture medium for the generation and maintenance of human pluripotent embryonic stem cells are disclosed. Human embryonic stem cells are cultured with human feeder cell conditioned medium, and the embryonic stem cells maintain their pluripotent phenotype. The human pluripotent embryonic stem cells can be cultured without feeder cells, and in the presence of supplemental growth factors. | 07-23-2009 |
