Entries |
Document | Title | Date |
20080254519 | Process for Producing Picolinic Acid Compounds - The present invention relates to a method for producing a picolinic acid compound. Specifically, the present invention relates to a method for producing a picolinic acid compound, which comprises reacting an aromatic compound that contains a phenyl group represented by the following formula (I), (II), or (III) with aromatic ring dioxygenase, aromatic ring dihydrodiol dehydrogenase, and aromatic ring diol dioxygenase, and obtaining a picolinic acid compound (I′), (II′), or (III′). | 10-16-2008 |
20080254520 | Method for reducing impurity level in mycophenolic acid fermentation - The present invention relates to methods for reducing impurities of mycophenolic acid during fermentation by controlling the level of carbon source during fermentation of mycophenolic acid and for the isolation and use as a standard marker of the impurity homo-mycophenolic acid. | 10-16-2008 |
20080274517 | PROCESS FOR THE MANUFACTURE OF NON-STEROIDAL ANTI-INFLAMMATORY AGENTS AND INTERMEDIATES THEREOF - The current invention describes novel chiral synthetic routes and intermediates for the manufacture of chiral anti-inflammatory agents of general formula VIII | 11-06-2008 |
20080286842 | Process for the Production of Macrolides Using a Novel Strain, Streptomyces Sp. Bicc 7522 - The present invention discloses a new strain of | 11-20-2008 |
20080318289 | Fermentation Processes for the Preparation of Tacrolimus - The present invention relates to improved fermentation processes for the preparation of tacrolimus or a salt or derivative thereof by culturing a microorganism capable of producing tacrolimus or a salt or derivative thereof under submerged aerobic conditions with fed-batch processing at a high aeration rate. | 12-25-2008 |
20090029426 | PROCESS FOR PREPARING RAPAMYCIN 42-ESTERS AND FK-506 32-ESTERS WITH DICARBOXYLIC ACID, PRECURSORS FOR RAPAMYCIN CONJUGATES AND ANTIBODIES - Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional activated ester of dicarboxylic acid with a lipase. | 01-29-2009 |
20090035829 | Enzymatic process for the preparation of paliperidone and its intermediate CMHTP - The present invention provides a process for the preparation of a 4H-pyrrido[1,2-a]-pyrimidin-4-one derivative, wherein the 4H-pyrrido[1,2-a]-pyrimidin-4-one derivative is Paliperidone or 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (‘CMHTP’), said process comprising enzymatically hydroxylating Risperidone or 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (‘ClMTTP’), respectively, with at least one oxidoreductase enzyme; and optionally isolating or purifying the Paliperidone or CMHTP, wherein the at least one oxidoreductase enzyme is selected from the group of peroxidases, dioxygenases, monooxygenases and any combination thereof. | 02-05-2009 |
20090081741 | SINGLE COLONIES OF MYXOBACTERIA CELLS - A single colony of myxobacterium cells, a process for its production and its use. A process for the production of a myxobacterium | 03-26-2009 |
20090087888 | PRODUCTION OF MONATIN STEREOISOMERS - Methods and materials for the production of the high intensity sweetener, monatin, in stereoisomerically-pure or stereoisomerically-enriched form are disclosed. For example, methods using stereoisoselective hydrolysis and separation of a monatin-derived lactone ester are disclosed. | 04-02-2009 |
20090093032 | PROCESS FOR PRODUCING 7-METHOXY-3-DESACETYLCEFALOTIN - Process for producing 7-methoxy-3-desacetylcefalotin by a hydrolysis process which takes place in water and is catalyzed by an enzyme. Cefoxitin can be obtained from this compound by known methods. | 04-09-2009 |
20090215134 | Genetically modified microorganism and process for production of macrolide compound using the microorganism - A genetically modified microorganism capable of directly producing a 16-hydroxylated macrolide compound; and a process for producing a 16-hydroxylated macrolide compound using the microorganism. Specifically, a genetically modified microorganisms having DNA encoding a polypeptide involved in the biosynthesis of a macrolide compound pladienolide and DNA encoding a polypeptide having a pladienolide 16-hydroxylase activity; and a process for producing a 16-hydroxylated macrolide compound comprising the steps of culturing the genetically modified microorganism in a culture medium and collecting a 16-hydroxylated macrolide compound from the culture medium. | 08-27-2009 |
20090269820 | Dna coding for polypeptide participating in biosynthesis of pladienolide - The present invention provides polypeptides that participate in the biosynthesis of the pladienolide macrolide compounds, DNA that encodes these polypeptides and variants of this DNA, transformants that maintain all or a portion of this DNA or variant thereof, and a method of producing the pladienolide macrolide compounds using these transformants. More particularly, it provides an isolated pure DNA that contains at least one region encoding a polypeptide that participates in pladienolide biosynthesis; polypeptide encoded by this DNA; a self-replicating or integrated-replicating recombinant plasmid carrying this DNA; a transformant maintaining this DNA; and a method of producing a pladienolide, characterized by culturing this transformant on culture medium and collecting pladienolide from this culture medium. | 10-29-2009 |
20090269821 | Method for Preparing Optically Active 4-Hydroxy-1,2,3,4-Tetrahydroquinoline Compound - The present invention relates to a method for preparing an optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound [I], which comprises the steps of: | 10-29-2009 |
20090298139 | Method for Polymer Synthesis Using Microfluidic Enzymatic Cascade - The present invention discloses a method for producing polymers in a microscale device. The system utilizes a symmetrically branched system of microchannels interconnecting a plurality of loading decks and re-action chambers. The fluid flow is manipulated by the placement of capillary check valves, mixing areas, and microcomb filters. The system provides for cascading enzymatic biosynthesis pathways wherein any variety of enzymes and reactants can be introduced into the system to produce a final product. | 12-03-2009 |
20090298140 | Solid State Matrix, Process of Preparation Thereof, and Process of Preparation of Theaflavins - The present invention relates to a process for the development of a highly efficient solid state matrix by the activation of acrylate based polymer resin having specialized functional groups with 1,1-Carboxyl diimidazole for immobilizing biologically active macromeloecules such as oxidases, in particular plant oxidases and the most preferred being tea polyphenol oxidase through indirect covalent bonding/cross linking on such activated polymer resin support, are thermally stable, gives very high number of turnovers in vitro (“n” times) with tea substrate forming exclusive product Theaflavins without any loss of biological activity and leaving the product remaining in vitro with adherence to matrix rendering the matrix safe towards product poisoning and subsequent partial or complete loss of biological activity of the matrix bound enzyme system and thus well adapted to and well suited biorectors based on such systems. It is unique with respect to its recyclability or otherwise uneconimical tea substrates such as seed and flower substrates into theaflavins both with respect to crude substrate or purified ones. | 12-03-2009 |
20100009417 | Chemoenzymatic process for the preparation of iminocyclitols - The present invention discloses a chemoenzymatic process for the preparation of an iminocyclitol corresponding to formula (I), (II), (III) or (IV), wherein: R | 01-14-2010 |
20110136185 | EPOTHILONES C, D, E, AND F, PREPARATION AND COMPOSITIONS - The present invention relates to epothilones C, D, E, and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection. | 06-09-2011 |
20110165632 | Process for the Preparation of an Orexin Receptor Antagonist - The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. | 07-07-2011 |
20110183384 | RECOMBINANT BACTERIA FOR PRODUCING DEOXYVIOLACEIN AND USES THEREOF - Recombinant bacteria for producing deoxyviolacein and uses thereof are provided, wherein the recombinant bacteria is obtained by introducing the deoxyviolacein synthesis-related gene cluster into | 07-28-2011 |
20110189740 | CATALYST FOR THE DECOMPOSITION OF LIGNIN, METHOD FOR THE PREPARATION OF ALCOHOLS AND ORGANIC ACIDS, METHOD FOR THE PREPARATION OF LIGNIN-DECOMPOSITION PRODUCTS, CATALYST FOR THE DECOMPOSITION OF AROMATIC HYDROCARBONS, METHOD FOR RELEASING HYDROGEN IONS, AS WELL AS PORPHYRIN - Herein provided are a lignin-decomposition catalyst and an aromatic hydrocarbon-decomposition catalyst, which contain a porphyrin. Alcohols and organic acids can be isolated or separated from lignin by adding a solution containing an alkaline compound to lignin, optionally acting a lignin-decomposition catalyst on the resulting lignin-alkaline compound-containing solution and optionally irradiating, with light rays, the solution; or by optionally acting a lignin-decomposition catalyst on lignin and then irradiating it with light rays. The decomposition products generated during the isolation of the foregoing alcohols and organic acids are recovered and hydrogen ions are released from lignin. Herein provided also include a porphyrin having such a catalytic function that it can convert lignin into alcohols and organic acids; a porphyrin having such a catalytic function that it can decompose a compound containing an aromatic hydrocarbon in which an oxygen is linked to a carbon atom constituting the benzene ring thereof; and a porphyrin obtained by cultivating | 08-04-2011 |
20110229941 | Novel Gene Cluster - Novel isolated DNA sequences which comprise all or part of a gene cluster encoding sanglifehrin synthase, processing and regulatory genes involved in the biosynthesis of a mixed non-ribosomal peptide/polyketide compound, or mutants having altered biosynthetic capability, polypeptides or mutants thereof encoded by DNA or the mutants, vectors containing the DNA or the mutants thereof, host cells transformed with the DNA, the mutants thereof, or the vector, and a method for producing sanglifehrin compounds. Compounds with cyclophilin inhibition activity used as immunosuppressants, antivirals or cardiac protection agents. | 09-22-2011 |
20120034660 | PROCESS FOR PRODUCING OPTICALLY ACTIVE SUCCINIMIDE DERIVATIVES AND INTERMEDIATES THEREOF - A process for producing optically active succinimide derivatives as key intermediates of (3R)-2′-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4′(1H)-pyrrolo[1,2-a]pyrazine}-1′,2,3′,5(2′H)-tetraone, which comprises the following reaction steps. | 02-09-2012 |
20120094335 | ARCHAEL LACCASES AND MULTICOPPER OXIDASES (MCOS) AND THEIR USES THEREOF - The subject invention pertains to a novel purified polypeptide having laccase activity and the nucleic acid sequences encoding the polypeptide. The disclosed polypeptide works at moderately high temperatures from below 20° C. to about 70° C., both acidic and alkaline pH conditions, high salt concentrations and in the presence of organo solvents. The high stability of the enzyme enables its wide applications under even extreme conditions. The invention also provides methods of producing the laccase enzyme. | 04-19-2012 |
20120295316 | PROCESS FOR PREPARATION OF TACROLIMUS - Genetically modified strains of | 11-22-2012 |
20130005001 | METHOD FOR PRODUCING NEBIVOLOL - The present invention relates to a method for producing racemic nebivolol represented by general formula (I) | 01-03-2013 |
20130177950 | PROCESS FOR PRODUCING REVEROMYCIN A OR A SYNTHETIC INTERMEDIATE THEREOF, PROCESS FOR PRODUCING COMPOUNDS CONTAINING A SPIROKETAL RING AND NOVEL ANTINEOPLASTICS, FUNGICIDES AND THERAPEUTIC AGENTS FOR BONE DISORDERS - A bacterium belonging to the genus | 07-11-2013 |
20130295622 | PROCESS FOR THE PREPARATION OF NEBIVOLOL - The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor. | 11-07-2013 |
20140106413 | IMMOBILIZED TRANSAMINASES AND PROCESS FOR MAKING AND USING IMMOBILIZED TRANSAMINASE - The invention is directed to immobilized transaminases and methods of making and using them. | 04-17-2014 |
20150056668 | SYNTHESIS OF PRAZOLE COMPOUNDS - The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides. | 02-26-2015 |
20150093793 | NOVEL METHOD FOR PRODUCING METABOLITES FROM OMEPRAZOLE USING BACTERIAL CYTOCHROME P450, AND COMPOSITION FOR SAME - The present invention relates to a novel method for producing metabolites from omeprazole using bacterial cytochrome P450, and a composition therefor, and more specifically, to a composition and a kit for producing a 5′-hydroxyl product from omeprazole, containing bacterial cytochrome P450 BM3 (CYP102A1) or mutants thereof, and to a method for producing the same. The composition, the kit, and the method are capable of economically and highly efficiently mass-producing the 5′-hydroxyl product from the omeprazole, and thus will significantly contribute to development of a novel drug using metabolites from the omeprazole. | 04-02-2015 |
20150147789 | Recombinant Non-Animal Cell for Making Biliverdin - Methods for producing biliverdin in a microorganism, methods for producing biliverdin from a non-animal source, cells for producing biliverdin and methods for producing cells for producing biliverdin are disclosed. | 05-28-2015 |
20160024542 | METHOD FOR PRODUCING BACTERIOCHLOROPHYLL A - A fed-batch fermentation method is for production of bacteriochlorophyll a (Bchla) from | 01-28-2016 |
20220135627 | THERMOSTABLE PHYCOBILIPROTEINS PRODUCED FROM RECOMBINANT ARTHROSPIRA - Provided herein are novel thermostable phycobiliproteins. These proteins may be stabilized by the introduction of disulfide bonds which stabilize the protein. Modified cells expressing these thermostable phycobiliproteins and methods of making them are also provided. | 05-05-2022 |