Class / Patent application number | Description | Number of patent applications / Date published |
435108000 | Tryptophan; tyrosine; phenylalanine; 3,4 dihydroxyphenylalanine | 44 |
20080241896 | PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE HYDROXYMETHYL-SUBSTITUTED PHENYLALANINE - The present invention provides a production method of optically active hydroxymethyl-substituted phenylalanine, which includes reducing cyano-substituted benzylidene hydantoin (1) to give aminomethyl-substituted benzyl hydantoin (2) or a salt thereof, converting an amino group of the aminomethyl-substituted benzyl hydantoin (2) or a salt thereof to a hydroxyl group to give hydroxymethyl-substituted benzyl hydantoin (3), treating the hydroxymethyl-substituted benzyl hydantoin (3) with an enzyme to give D-hydroxymethyl-substituted phenylalanine (4 | 10-02-2008 |
20080311631 | Biosynthetic Production of 4-Amino 4-Deoxychorismate (Adc) and [3R,4R]-4-Amino-3-Hydroxycyclohexa-1,5-Diene-1-Carboxylic Acid (3,4-Cha) - The invention relates to a process for the biosynthetic production of 4-amino-4-deoxychorismate (ADC) performed fermentatively in vivo with a 4-amino-4-deoxychorismate synthase, preferably a PabAB bipartite protein (which may be a fusion protein), at an increased level of activity, thereby obtaining a broth comprising ADC and 4-amino-4-deoxyprephenate (ADP), that are recovered. The invention also relates to a further process of converting the ADP into p-aminophenylalanine. The invention, moreover relates to biosynthetic production of [3R,4R]-4-amino-3-hydroxycyclohexa-1,5-diene-1-carboxylic acid (3,4-CHA), by concerted action of such 4-amino-4-deoxychorismate synthase and of an enzyme capable of converting isochorismate into [5S,6S]-5,6 dihydroxycyclohexa-1,3-diene-1-carboxylic acid (2,3-CHD), preferably a phenazine biosynthesis protein PhzD, including recovery of 3,4-CHA. The invention also relates to expression vectors and host cells for use in any of such processes. The invention further relates to the use of 3,4-CHA as a catalytically active product, in particular as a chiral catalyst. And the invention finally relates to synthesis of oseltamivir phosphate from 3,4-CHA. | 12-18-2008 |
20090068712 | AMINO ACID PRODUCING MICROORGANISM AND A METHOD FOR PRODUCING AN AMINO ACID - A microorganism is provided which has an ability to produce an L-amino acid such as L-lysine, L-tryptophan, L-phenylalanine, L-valine, L-leucine, L-isoleucine and L-serine, and has been modified to increase the activity of pyruvate synthase or pyruvate:NADP | 03-12-2009 |
20090081739 | PROCESS FOR PRODUCING AMINO ACIDS - The present invention provides: a process for producing an amino acid which comprises adding crystals of the amino acid having an average particle size of 1 to 120 μm to a medium so that the concentration of the crystals of the amino acid becomes 0.5 g/l or more, culturing a microorganism having the ability to produce the amino acid in the medium, allowing crystals of the amino acid to form and accumulate in the medium, and recovering the crystals of the amino acid from the culture; and a process for producing an amino acid which comprises adding crystals of the amino acid to a medium so that the total surface area of the crystals of the amino acid in the medium becomes 0.02 m | 03-26-2009 |
20090087887 | METHOD FOR PRODUCING L-AMINO ACID - An L-amino acid is produced by culturing an L-amino acid-producing bacterium which belongs to the | 04-02-2009 |
20090093029 | METHOD FOR PRODUCING L-AMINO ACID - An L-amino acid is produced by culturing an Enterobacteriaceae which is able to produce an L-amino acid in a medium containing glycerol, especially crude glycerol, as the carbon source to produce and accumulate the L-amino acid in the culture, and collecting the L-amino acid from the culture. | 04-09-2009 |
20090191600 | METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-BETA-ESTER AND METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-ALPHA-METHYL ESTER - A method for producing an α-L-aspartyl-L-phenylalanine-β-ester (also named α-L-(β-o-substituted aspartyl)-L-phenylalanine), which is an intermediate of an α-L-aspartyl-L-phenylalanine-α-methyl ester (also named α-L-aspartyl-L-phenylalanine methyl ester; product name: aspartame), easily, at high yield and inexpensively without going through a complex synthesis method is provided. Further, an easy, inexpensive and high-yield production method for an α-L-aspartyl-L-phenylalanine-α-methyl ester is provided. α-L-aspartyl-L-phenylalanine-α-methyl ester is produced from a L-aspartic acid-α,β-diester and L-phenylalanine using an enzyme or enzyme-containing substance that has an ability to catalyze a reaction in which L-phenylalanine performs no nucleophilic attack on a β-ester site of L-aspartic acid-α,β-diester but performs a nucleophilic attack on an α-ester site thereof. | 07-30-2009 |
20090191601 | METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE ydiN GENE OR THE ydiB GENE OR COMBINATION THEREOF - The present invention provides a method for producing an aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus | 07-30-2009 |
20090239268 | METHOD FOR PRODUCING AN L-AMINO ACID - The present invention provides a method for producing an L-amino acid by fermentation by culturing a microorganism having an L-amino acid-producing ability in a liquid medium to precipitate the L-amino acid, wherein a polymer such as a water-soluble cellulose derivative, a water-soluble polyvinyl compound, a polar organic solvent-soluble polyvinyl compound, a water-soluble starch derivative, an alginic acid salt, and a polyacrylic acid salt is added to the medium. | 09-24-2009 |
20090246835 | L-AMINO ACID-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING AN L-AMINO ACID - An L-amino acid is produced by culturing a microorganism of the family Enterobacteriaceae which has the ability to produce an L-amino acid and which has been modified so as to increase the expression of the evgA gene, the gadE gene, and/or the ydeO gene. These genes encode a transcription factor involved in the EvgAS two-component system regulon. The culture takes place in a medium, and the L-amino acid is collected from the medium or cells. | 10-01-2009 |
20090258400 | Mutant Tyrosine Repressor, a Gene Encoding the Same, and a Method for Producing L-Dopa - A mutant tyrosine repressor that does not require tyrosine to induce expression of tyrosine phenol-lyase gene is obtained by introducing a mutation into a tyrosine repressor. A microorganism which is able to express large amounts of tyrosine phenol-lyase is obtained by introducing the mutant tyrosine repressor into the microorganism. The microorganism is useful for producing L-DOPA. | 10-15-2009 |
20090258401 | L-AMINO ACID PRODUCING BACTERIUM AND METHOD OF PRODUCING L-AMINO ACID - L-amino acid is produced by culturing a bacterium belonging to the Enterobacteriaceae family which has L-amino acid-producing ability and is modified so that expression of the nhaA gene, nhaB gene, nhaR gene, chaA gene, mdfA gene, or combinations thereof is enhanced. | 10-15-2009 |
20100028956 | GENETICALLY ENGINEERED RECOMBINANT ESCHERICHIA COLI PRODUCING L-TRYPTOPHAN HAVING ORIGINALLY L-PHENYLALANINE PRODUCTIVITY, AND METHOD FOR PRODUCING L-TRYPTOPHAN USING THE MICROORGANISM - The present invention relates to a microorganism having L-tryptophan productivity and a method for producing L-tryptophan using the same. More precisely, the present invention relates to the recombinant | 02-04-2010 |
20100093044 | AMINO ACID PRODUCING MICROORGANISM AND A METHOD FOR PRODUCING AN AMINO ACID - A microorganism is provided which has an ability to produce an L-amino acid such as L-lysine, L-tryptophan, L-phenylalanine, L-valine, L-leucine, L-isoleucine and L-serine, and has been modified to increase the activity of pyruvate synthase or pyruvate:NADP | 04-15-2010 |
20100099153 | Method for producing L-amino acids using bacteria belonging to the genus escherichia - A method for producing lower alkyl ester of α-L-aspartyl-L-phenylalanine by cultivating a recombinant | 04-22-2010 |
20100143982 | METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE aldH GENE - The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus | 06-10-2010 |
20100184162 | METHOD FOR PRODUCTION OF AN L-AMINO ACID - A method is provided for producing an L-amino acid by culturing a microorganism belonging to the Enterobacteriaceae family and having the ability to produce an L-amino acid, in a medium to produce and accumulate the L-amino acid in the medium. The microorganism has been modified by introduction of a DNA fragment which includes a pho regulon promoter and a structural gene encoding an L-amino acid biosynthetic enzyme, which is ligated downstream of the promoter so that the gene is expressed by the promoter, and so that the activity of the L-amino acid biosynthetic enzyme is increased by the expression of the gene by the promoter. In this way, the L-amino acid that is produced in the medium can be collected. Furthermore, the phosphorus concentration in the medium is such that the expression of the gene by the promoter is induced. | 07-22-2010 |
20100221793 | METHOD FOR PRODUCING BETA-AMINO ACID - Disclosed is a method for producing a β-amino acid comprising a step of synthesizing a β-amino acid from an α-amino acid in the presence of an amino acid aminomutase. In this method, a β-amino acid is precipitated as a solid in the reaction solution. | 09-02-2010 |
20100304449 | Method for Obtaining Products Containing Different Concentrations of Compounds Produced by Fermentation - The invention relates to a method for producing different products comprising a target substance, particularly amino acids or vitamins, wherein the target substance is produced by fermentation. | 12-02-2010 |
20110045547 | ISOMERASES AND EPIMERASES AND METHODS OF USING - The invention provides for isomerase (e.g., racemase) and epimerase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such isomerase (e.g., racemase) and epimerase nucleic acids and polypeptides. | 02-24-2011 |
20110045548 | NOVEL HYDROGEN PEROXIDE-FORMING NADH OXIDASE AND DNA ENCODING THE SAME - It is an object of the present invention to provide DNA encoding novel NADH oxidase from a microorganism belonging to the genus | 02-24-2011 |
20110111466 | Microorganisms for Producing L-Amino Acids and Process for Producing L-Amino Acids Using Them - The present invention relates to a transformed microorganism producing an L-amino acid using sucrose as a main carbon source, and a method for producing an L-amino acid using the same. | 05-12-2011 |
20110117613 | METHOD FOR PRODUCTION OF L-AMINO ACID - An L-amino acid can be produced by culturing a bacterium which belongs to the Enterobacteriaceae family, and has an enhanced ability to use a fatty acid. The bacterium is capable of producing the L-amino acid in a culture medium containing a fatty acid or a hydrolysate of an oil-and-fat as a carbon source, thereby producing and accumulating the L-amino acid in a culture. | 05-19-2011 |
20110171695 | ALLELES OF THE PRPD1 GENE FROM CORYNEFORM BACTERIA - An isolated mutant of coryneform bacteria comprising a gene encodes a polypeptide having 2-methylcitrate dehydratase activity, where the polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids except L-proline is present at position 272 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having 2-methylcitrate dehydratase enzymic activity, which comprises at position 272 of the amino acid sequence or a corresponding or comparable position a proteinogenic amino acid except L-proline is described. A method for producing a recombinant coryneform bacterium and L-amino acids. A recombinant microorganism, L-Lysine-containing feed additive, and L-Tryptophan-containing feed additive is also described. | 07-14-2011 |
20110300588 | MUTATIONS AND GENETIC TARGETS FOR ENHANCED L-TYROSINE PRODUCTION - The invention relates to identification of mutations and genetic targets for enhanced L-tyrosine production, and bacterial strains capable of L-tyrosine production. | 12-08-2011 |
20120015409 | PROCESS FOR PRODUCING L-AMINO ACID - The present invention provides a method of improving efficiency of a fermentative production of an L-amino acid. To be specific, the present invention provides a process for producing a L-amino acid, comprising culturing a microorganism wherein the activity of the protein described in any one of (1) to (3) below is higher than that of the parent strain in a medium to produce the L-amino acid and accumulate the L-amino acid in the medium, and then collecting the L-amino acid from the medium: | 01-19-2012 |
20120164698 | METHOD FOR FERMENTATIVELY PREPARING L-AMINO ACIDS - The invention relates to a method for preparing organic-chemical compounds, characterized in that the following steps are carried out: a) fermentation of a microorganism secreting an L-amino acid, which microorganism contains an overexpressed polynucleotide coding for a polypeptide having polyphosphate-dependent NAD | 06-28-2012 |
20120219995 | METHOD FOR PRODUCING AN L-AMINO ACID - A method for producing an L-amino acid which includes the steps of culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid producing ability in a medium to produce and accumulate an L-amino acid in the medium, and collecting the L-amino acid from the medium, wherein the bacterium has been modified so that an activity or activities of one or two or more enzymes of the arginine succinyltransferase pathway, such as arginine succinyltransferase, succinylarginine dihydrolase, succinylornithine aminotransferase, succinylglutamate-semialdehyde dehydrogenase, and succinylglutamate desuccinylase, is/are decreased. | 08-30-2012 |
20130005000 | MUTANT rpsA GENE AND METHOD FOR PRODUCING L-AMINO ACID - A method for efficiently producing an L-amino acid utilizing a bacterium belonging to the family Enterobacteriaceae from a fatty acid or an alcohol such as glycerol as a raw material is provided. A bacterium belonging to the family Enterobacteriaceae which is able to produce L-amino acid and harbors an RpsA protein which has a mutation such that the native aspartic acid residue at position 210 is replaced with another amino acid residue is used. This bacterium is cultured in a medium containing a carbon source selected from a fatty acid and an alcohol, and the produced L-amino acid is collected from the medium. | 01-03-2013 |
20130288314 | PROTECTIVE STRUCTURE OF SUBSTANCE TO BE PROTECTED, METHOD OF PROTECTING SUBSTANCE TO BE PROTECTED, ENZYMATIC REACTION METHOD, METHOD OF PRODUCING REACTION PRODUCT, METHOD FOR ADJUSTING THE SPEED OF ENZYMATIC REACTION, AND ENZYME MATERIAL USE KIT - Disclosed are a structure and a method capable of protecting from outside stimuli while containing in a liquid state a water-dispersible substance to be protected. The protective structure of the substance to be protected is a water-in-oil emulsion structure comprising an aqueous phase configuring a discontinuous phase containing the water-dispersible substance to be protected, an oil phase in which said aqueous phase is dispersed, and either vesicles formed with an amphiphilic substance which spontaneously forms vesicles or polycondensation polymer particles having hydroxyl groups. | 10-31-2013 |
20140024087 | MICROORGANISM HAVING ENHANCED L-AMINO ACIDS PRODUCTIVITY AND PROCESS FOR PRODUCING L-AMINO ACIDS USING THE SAME - A microorganism of the genus | 01-23-2014 |
20140065679 | PRODUCTION OF ENANTIOMERICALLY PURIFIED AMINO ACIDS - The present application relates to a mutated | 03-06-2014 |
20140080185 | Method for Producing a Target Substance by Fermentation - A method is described for producing a target substance utilizing a microorganism by culturing the microorganism in a medium to produce and accumulate the target substance in the medium, and then collecting the target substance from culture. The microorganism is imparted with isomaltase activity, or modified to increase isomaltase activity. | 03-20-2014 |
20140141473 | YEAST CELL CAPABLE OF CONVERTING SUGARS INCLUDING ARABINOSE AND XLOSE - Yeast cell belonging to the genus | 05-22-2014 |
20140212931 | Bacterial Iodoperoxidases from Zobellia Galactanivorans, Methods of Preparation and Uses Thereof - The present invention concerns iodoperoxidases from | 07-31-2014 |
20140377814 | Method For The Fixation Or Conversion Of High-Pressure Carbon Dioxide Using Barophilic Sulfur-Oxidizing Chemolithoautotrophs - The present invention relates to a method for biologically treating carbon dioxide using the sulfur-oxidizing chemolithoautotroph | 12-25-2014 |
20150037849 | MICROORGANISMS FOR THE PRODUCTION OF 5-HYDROXYTRYPTOPHAN - Recombinant microbial cells and methods for producing 5-hydroxytryptophan (5HTP) using such cells are described. More specifically, the recombinant microbial cell comprises an exogenous gene encoding an L-tryptophan hydroxylase, and means for providing tetrahydrobiopterin (THB). Related sequences and vectors for use in preparing such recombinant microbial cells are also described. | 02-05-2015 |
20150044734 | METABOLIC ENGINEERING OF THE SHIKIMATE PATHWAY - The present disclosure relates to engineered microorganisms that produce amino acids and amino acid intermediates. In particular, the disclosure relates to recombinant nucleic acids encoding operons that increase production of aromatic amino acids and the aromatic amino acid intermediate shikimate; microorganisms with increased production of aromatic amino acids and the aromatic amino acid intermediate shikimate; and methods related to the production of aromatic amino acids, the aromatic amino acid intermediate shikimate, and commodity chemicals derived therefrom. | 02-12-2015 |
20150050703 | Microorganism able to Produce L-Amino Acid, and Method for Producing L-Amino Acid by Using the Same - The present invention relates to a microorganism able to produce L-threonine or L-tryptophan, and to a method for producing L-threonine or L-tryptophan by using same. More specifically, the present invention relates to: recombinant | 02-19-2015 |
20150056667 | MUTANTS OF HYDANTOINASE - The present invention relates to a hydantoinase having an amino acid sequence selected from (i) or (ii), with (i) amino acid sequence selected from SEQ ID NO: 6-20 and SEQ ID NO: 73-119 (ii) amino acid sequence wherein in the amino acid sequence of SEQ ID NO: 6-20 and SEQ ID NO: 73-119, 1 to 75 amino acid residues have been substituted, deleted, inserted and/or added, and wherein further the catalytic activity of the hydantoinase is higher by a factor of at least 1.2 than the catalytic activity of the hydantoinase having amino acid sequence SEQ ID NO: 1, The present invention further relates to a process for preparing amino acids, wherein said hydantoinase is used. | 02-26-2015 |
20150147788 | Microorganism of the Genus Escherichia Having Enhanced L-Tryptophan Productivity and a Method for Producing L-Tryptophan Using the Same - The present invention relates to microorganisms of | 05-28-2015 |
20160060638 | PRECURSOR-DIRECTED BIOSYNTHESIS OF 5-HYDROXYTRYPTOPHAN - The invention provides compounds, compositions, non-naturally occurring organisms, and methods useful for production of 5-hydroxytryptophan (5-HTP) in a microbial cell. A microbial system which includes at least one microbial cell, such as a bacterial cell or a yeast cell, is genetically engineered to express all or a portion of non-naturally occurring biosynthetic pathway that catalyzes the conversion of a simple carbon source, such as glucose, to 5-HTP. The invention can result in improved titers of 5-HTP and permits low-cost, large scale production. Methods of making and using the genetically engineered cells are also included in the invention. | 03-03-2016 |
20160153014 | MICROORGANISMS HAVING L-TRYPTOPHAN PRODUCTIVITY AND A METHOD FOR PRODUCTION OF L-TRYPTOPHAN USING SAME (AS AMENDED) | 06-02-2016 |
20160251688 | BENZYLISOQUINOLINE ALKALOID (BIA) PRECURSOR PRODUCING MICROBES, AND METHODS OF MAKING AND USING THE SAME | 09-01-2016 |