Class / Patent application number | Description | Number of patent applications / Date published |
435710200 | Procaryotic micro-organism | 38 |
20090042254 | EXPRESSION OF SOLUBLE ANTIBODY FRAGMENT BY TRUNCATION OF CH1 DOMAIN - Improved expression of active antibody fragments (Fabs) is achieved by truncating a heavy chain constant region. Truncation of the C | 02-12-2009 |
20090053767 | METHOD FOR PRODUCING HUMAN INSULIN-LIKE GROWTH FACTOR I - A method is provided for producing hIGF-I with high purity and yield. This is a method for producing human insulin-like growth factor I, having a step of removing modified human insulin-like growth factor I from the human insulin-like growth factor I, the step including:
| 02-26-2009 |
20090053768 | Novel Phospholipase C Enzyme (S) - The present invention provides a phospholipase C enzyme(s) having ability to hydrolyze phospholipid in both acidic and around neutral ranges and the activity in a citrate buffer solution as well as having some degree of heat stability, and having a property not to hydrolyze phosphate esters not containing lipid moieties. The phospholipase C enzyme(s) shows the activity at from acidic to neutral pH and does not substantially hydrolyze any phosphate esters except for phospholipids. | 02-26-2009 |
20090186382 | Preparation of Romidepsin - The invention provides an improved process for preparing romidepsin. The process involves producing, purifying, or storing romidepsin under conditions that prevent the formation of undesired adducts. Purifying romidepsin at an apparent pH lower than approximately 6.0 (e.g., between an apparent pH of 4.0 and 6.0) has been discovered to prevent the reduction of the disulfide bond of romidepsin and the subsequent formation of dimerized, oligomerized, or polymerized adducts. The invention also provides compositions of monomeric romidepsin free of dimerized, oligomerized, or polymerized adducts. | 07-23-2009 |
20090239264 | Immunization with bacterial ghost-based vaccines - Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a protein, lipoteichoic acid or carbohydrate from the cell-wall material and contacting the proteinaceous substance with the cell-wall material. | 09-24-2009 |
20090305354 | PROCESS FOR PREPARING HUMAN G-CSF - The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase. | 12-10-2009 |
20090311751 | Wood-rotting basidiomycetes for production of ligninolytic enzymes - The invention relates to the production of ligninolytic enzymes, laccase and manganese peroxidase, from certain white-rot basidiomycetes fungi, using highly efficient fermentation techniques. The aim of this invention is to create a novel economically and time-effective overall procedure comprising use of specific mushroom strains, fermentation process and the isolation-purification techniques, for producing the aforesaid enzymes. In particular, a submerged fermentation of the specific strains on a variety of lignocellulosic substrates from organic wastes like waste of ethanol production from wheat grain, mandarin peels and bran is developed. Culturing conditions can be selected to modify the laccase/manganese peroxidase ratio in favour of the production of either laccase or manganese peroxidase. | 12-17-2009 |
20090317871 | BACILLUS LICHENIFORMIS B1, ALKALOPHILIC ENZYME SOLUTION AND METHOD OF PRODUCING THE SAME - The present invention relates to | 12-24-2009 |
20100028952 | FERMENTATION AND PURIFICATION OF ACTINOMADURA CHROMOPROTEIN AND RELATED SPECIES - The present invention provides methods for production and purification of active chromoproteins produced by | 02-04-2010 |
20100047872 | PROCESS FOR PRODUCING USEFUL SUBSTANCE - The present invention provides a process for producing a useful substance by use of a microorganism that lacks in their chromosomal DNA all or part of a gene encoding a protein having the amino acid sequence shown in SEQ ID NO: 1 or a gene encoding a protein having 80% or more, preferably 90% or more, more preferably 95% or more, even more preferably 97% or more, still more preferably 98% or more, and yet more preferably 99% or more homology with the amino acid sequence shown in SEQ ID NO: 1. | 02-25-2010 |
20100047873 | PROCESS FOR THE PRODUCTION OF DAPTOMYCIN - The present invention relates to an improved process for the production of Daptomycin by fermentation with | 02-25-2010 |
20100086971 | GROWTH MEDIUM FOR CLOSTRIDIUM HISTOLYTICUM - The present invention provides improved media for the cultivation of | 04-08-2010 |
20100086972 | Process for the production of biodegradable, functionalised polymer particles and use thereof as pharmaceutical supports - The invention relates to a method for producing biodegradable, functionalised polymer particles, and to the use of the same as medicament carriers. | 04-08-2010 |
20100112642 | Production Of CPD Glycosylases - Recombinant forms of DNA sequences for CPD glycosylases, including the bacteriophage T4 gene denV, are described that are capable of expression at high levels. Active CPD glycosylases can be recovered from inclusion bodies resulting from the high expression using, for example, a homogenization process which employs stream mixing, and the active proteins can be used in, for example, topical formulations for treatment of photosensitive diseases. Stream mixing can also be used to solubilize inclusion bodies containing proteins other than CPD glycosylases. | 05-06-2010 |
20100203592 | METHOD FOR PRODUCTION OF GLUTATHIONE OR GAMMA-GLUTAMYLCYSTEINE - The invention provides a process for producing glutathione or γ-glutamylcysteine by culturing in a medium a microorganism with a higher activity of a protein having an activity to transport intracellular glutathione to the outside of cells, and a higher activity of a protein involved in glutathione or γ-glutamylcysteine biosynthesis, compared with that of the parent strain, forming and accumulating glutathione or γ-glutamylcysteine in the medium, and recovering the glutathione or γ-glutamylcysteine from the culture. | 08-12-2010 |
20100291630 | METHOD FOR PRODUCING A FOAMING AGENT - A method for producing a foaming agent is provided, the method comprising cultivating a host cell in a fermentation medium wherein the host cell extra-cellularly secretes a foaming agent and wherein the fermentation medium contains an antifoam which has a cloud point; and then removing the antifoam5 while the temperature of the fermentation medium is above the cloud point. | 11-18-2010 |
20100297703 | Lytic Enzyme Inhibitor, Lysis Inhibitor, Inhibitor of Poly-y-glutamic Acid Degradation, and Method for Producing Poly- y-glutamic Acid - This invention relates to inhibition of microbial lysis via regulation of activity of a lytic enzyme for degrading the cell wall. The lytic enzyme inhibitor and the lysis inhibitor are each composed mainly of the | 11-25-2010 |
20100317057 | SEMI-RECOMBINANT PREPARATION OF GLP-1 ANALOGUES - A semi-recombinant method for the production of GLP-1 analogues and derivatives with non-proteogenic amino acids in the N-terminal part combining the use of recombinant expression techniques and chemical peptide synthesis. | 12-16-2010 |
20110117605 | Methods for Manufacturing a Polyclonal Protein - The invention relates to methods for manufacturing drug products comprising at least two distinct members of a polyclonal protein, for example a polyclonal antibody, where each distinct member is expressed by a separate population of cells. The methods involve at least an initial step in which the cell populations expressing the distinct members of the polyclonal protein are cultured separately. The individual cell populations, or proteins expressed by the individual cell populations, are combined at a later point of the upstream or downstream processing to result in a single drug product comprising the distinct members of the polyclonal protein. | 05-19-2011 |
20110136174 | METHOD FOR PRODUCING CELLULOLYTIC ENZYME USING CLOSTRIDIUM MICROORGANISM AND METHOD FOR CULTURING AND PROLIFERATING CLOSTRIDIUM MICROORGANISM - A method for producing cellulolytic enzyme, where | 06-09-2011 |
20120219994 | PROPHAGE ELEMENT-FREE BACTERIA - The present invention provides a bacterium having a genome that is genetically engineered to be smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a commercial product more efficiently. The present invention also provides methods for deleting genes and other DNA sequences from a bacterial genome. The methods provide precise deletions and seldom introduces mutations to the genomic DNA sequences around the deletion sites. Thus, the methods can be used to generate a series of deletions in a bacterium without increasing the possibility of undesired homologous recombination within the genome. In addition, some of the methods provided by the present invention can also be used for replacing a region of a bacterial genome with a desired DNA sequence. | 08-30-2012 |
20120264172 | Protein from Photobacterium Damselae and Use Thereof - A derivative of a 55 kDa extracellular protein from | 10-18-2012 |
20120329095 | METHOD OF PRODUCING SUCCINIC ACID - Provided is a method of producing succinic acid in which a microorganism having a succinic acid-producing ability is allowed to react with a sugar, the method being characterized in that the ratio of the oxygen transfer rate to the succinic acid production rate (mmol-O | 12-27-2012 |
20130004993 | Green Chemical Process to Produce Natural Products - Methods for producing and obtaining natural products from microbial amplification chambers are described. This approach utilizes the concept of green chemistry to synthesize and extract the marine and terrestrial natural products. The method describes techniques to colonize and grow the selected bacteria and to continuously harvest the pharmaceutical agent from the broth without using any commercial solvents. | 01-03-2013 |
20140099672 | Method for Preparing Polymeric Protein Composed of Monomeric Protein Produced by Fusing Protein Having Immunoglobulin Fold Structure to Protein Capable of Serving as Subunit Structure - The present invention provides a method for producing a multimeric protein composed of a monomeric protein, wherein the monomeric protein is obtained by fusing a protein having an immunoglobulin fold structure to a protein that can serve as a subunit structure, the method including the steps of:
| 04-10-2014 |
20150010948 | FERMENTATION PROCESS - A process for fermenting | 01-08-2015 |
20150111254 | METHOD FOR AEROBICALLY PRODUCING ALANINE OR A COMPOUND PRODUCED USING ALANINE - The problem addressed by the invention is solved in a first aspect by a method for producing alanine or a compound produced using alanine, having the steps of (a) providing a cell which expresses a recombinant alanine dehydrogenase or a variant thereof, (b) cultivating the cell under aerobic conditions in the presence of an inorganic nitrogen source in an aqueous phase, and (c) bringing the cell into contact with an organic phase, said cell being a prokaryotic or a lower eukaryotic cell. | 04-23-2015 |
20150305370 | METHODS FOR MANAGING THE COMPOSITION OF DISTILLERS GRAIN CO-PRODUCTS - The present invention provides for methods of managing the protein content of multiple distiller's grain co-products of a fermentation process. A valuable protein rich distiller's grain co-product having greater than 40 wt % protein on a dry basis can be removed from whole stillage or spent grains; however the protein content in the residual wet cake is reduced. The present invention provides for methods to mitigate protein depletion in wet cake by removing non-protein components from the wet cake stream, from the low protein thin stillage stream added to wet cake, or both streams. The present invention provides for blending protein depleted and protein enriched streams to meet the protein specifications of multiple distiller's grain co-products. | 10-29-2015 |
20150315538 | METHODS OF MICROALGAE CULTIVATION FOR INCREASED RESOURCE PRODUCTION - Methods of inducing or increasing lipid and protein production in microalgae are disclosed. Methods of enhancing microalgae biomass are also disclosed. The methods may comprise inoculating a culture media with microalgae and propagating the microalgae under heterotrophic growth conditions. The heterotrophic growth conditions may comprise inhibiting exposure of the inoculated culture media to light. The methods may further comprise delivering oxygen into the inoculated culture media. Additionally, lipids, proteins, and other cellular components may be isolated and purified from microalgae cultivated under the disclosed methods. | 11-05-2015 |
20160186226 | METHOD FOR PRODUCING EXTRACELLULAR PROTEINS FROM GENUS TEPIDIMONAS - The disclosure provides a method for producing extracellular proteins from genus | 06-30-2016 |
435710300 | Antibiotic or toxin | 8 |
20090053769 | HETEROLOGOUS PRODUCTION OF NATURAL PRODUCTS IN BACTERIA - The present invention demonstrates an example of the de novo total biosynthesis of biologically active forms of heterologous NRPs in | 02-26-2009 |
20090068706 | Production of Highly Isotopically Labelled, Secondary, Microbial Metabolic Products, and Corresponding Metabolic Products - The invention relates to a method for producing isotopically labelled secondary metabolic products of fungi or bacteria in a liquid synthetic culture medium. According to said method, the synthesis is carried out by immobilizing the fungi or bacteria on an inert carrier, adding a liquid synthetic culture medium in which essentially all of the carbon atoms, nitrogen atoms and/or sulphur atoms are replaced by stable isotopes. | 03-12-2009 |
20090197305 | PROCESS FOR THE PREPARATION OF POLYMYXIN B EMPLOYING (PAENI) BACILLUS POLYMYXA - The invention is related to the process of fermentation with production strain | 08-06-2009 |
20110008843 | PROCESS FOR OBTAINING BOTULINUM NEUROTOXIN - Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield | 01-13-2011 |
20110091937 | Method of Producing Clostridium Botulinum Toxin Using Media Containing Plant-Derived Components and Flexible Closed Container - Provided are a method of producing | 04-21-2011 |
20110229934 | PROCESS FOR THE PRODUCTION OF THE ACTINOBACILLUS PLEUROPNEUMONIAE TOXINS APXI OR APCIII IN A LIQUID CULTURE MEDIUM UNDER SUPPLY OF AIR ENRICHED IN CARBON DIOXIDE - The current invention pertains to a method to produce RTX-toxins ApxI or ApxIII by culturing | 09-22-2011 |
20110229935 | PROCESS FOR THE PRODUCTION OF THE ACTINOBACILLUS PLEUROPNEUMONIAE TOXIN APXI EMPLOYING A CULTURE MEDIUM COMPRISING CALCIUM-BOROGLUCONATE COMPLEX - The present invention pertains to a method to produce RTX-toxin Apxl by culturing | 09-22-2011 |
20140087425 | METHODS FOR PREPARING PURIFIED LIPOPEPTIDES - The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions. | 03-27-2014 |