Class / Patent application number | Description | Number of patent applications / Date published |
427200210 | Retarded or controlled-release layer produced (e.g., enteric) | 21 |
20090098275 | ENTERIC COATINGS FOR ORALLY INGESTIBLE COMPOSITIONS - A dry suspendible enteric coating composition for suspension in water and then encasing orally ingestible articles. The dry suspendible enteric coating composition comprises a pH-dependent polymer selected from a group containing alginates and alginic acids, a pH-independent water insoluble polymer selected from the group comprising ethylcellulose and ethylcellulose-containing compositions, and a plasticizer selected from the group containing triethyl citrate, glycerin, propylene glycol, triacetin, acetylated monoglycerides, dibutyl sebacate, polyethylene glycols, sorbitals, middle chain triglycerides and combinations thereof. A three-step method for providing a stable outer enteric coating on an ingestible item comprising a first step of encasing the item with a suspension comprising a mixture of at least a sugar and a microcrystalline cellulose, a second step of then encasing the item with a suspension comprising a mixture of a film-forming polymer and a plasticizer, and a third step of finally encasing the item with the enteric coating composition. | 04-16-2009 |
20090285974 | METHOD FOR ELECTROSTATIC COATING OF A MEDICAL DEVICE - A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device. | 11-19-2009 |
20100119694 | SUSTAINED RELEASE DRUG DELIVERY DEVICES, METHODS OF USE, AND METHODS OF MANUFACTURING THEREOF - A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled. | 05-13-2010 |
20100173065 | Methods For Immobilizing Anti-Thrombogenic Material Onto A Medical Device Or Into A Coating Thereon - The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided. | 07-08-2010 |
20100233350 | Drug delivery composition and methods of making same using nanofabrication - The present invention relates to drug delivery compositions, drug delivery units, drug delivery devices and methods of making the same using nanofabrication processes. The nanofabrication processes are used to make pores in a matrix. Exemplary nanofabrication processes include nanoimprinting, reverse imprinting, nanolithography, and photolithography. | 09-16-2010 |
20100323091 | Methods To Increase Fracture Resistance Of A Drug-Eluting Medical Device - Methods for increasing the fracture resistance of a polymer stent's drug-polymer coating and scaffolding including applying a coating and crimping using techniques that increase the resistance to fracture in the coating layer and scaffolding and scaffolding. | 12-23-2010 |
20110076385 | ION EXCHANGE RESIN TREATED TO CONTROL SWELLING - The present invention provides a method and composition for loading one or more drugs in a solution onto one or more ion exchange resin particles to form a drug-loaded resin particle. The drug-loaded resin particle is separated from the solution and dried before recombining the drug-loaded resin particle with the solution to load more drugs onto the drug-loaded resin particle from the solution. | 03-31-2011 |
20110217448 | METHOD FOR PREPARATION OF A CONTROLLED RELEASE SYSTEM - The present invention relates to a method for the preparation of a controlled release system and especially to a method for entrapment of compounds in polymer carriers for controlled release of active ingredients, preferably bioactive ingredients, such as drugs. This method results in a system for controlled release of active ingredients and especially for controlled drug delivery. In accordance with the present invention, the tem controlled release ” encompasses all kinds of controlled release, including slow release, sustained and delayed release. Particularly, the present invention results in active ingredients, entrapped in or otherwise incorporated in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer devices for controlled release; the active ingredients are covalently bonded to the polymer carriers or polymeric devices. | 09-08-2011 |
20120196028 | PREPARATION OF CONTROLLED RELEASE SKELETAL MUSCLE RELAXANT DOSAGE FORMS - The present invention is directed to a method of preparing an extended release pharmaceutical composition comprising cyclobenzaprine, comprising coating inert particles with a cyclobenzaprine-containing a drug layering composition to form IR beads, then coating the IR beads with an extended-release coating to form ER beads. | 08-02-2012 |
20120213910 | Tablets with Site- and Time- Controlled Gastrointestinal Release of Active Ingredient - The present invention describes a pharmaceutical dosage form with site- and time-controlled gastrointestinal release of active ingredient. | 08-23-2012 |
20130011543 | CONTROLLED RELEASE OXYCODONE COMPOSITIONS - A method for preparing a solid oral dosage form comprising up to about 160 mg of oxycodone or a salt thereof to control pain in substantially all patients is disclosed. The method comprises forming spheroids comprising a spheronising agent and oxycodone or a salt thereof, and coating the spheroids with a controlled-release film coat. Repeated “q12h” (i.e., every 12 hour) administration of the dosage form through steady-state conditions results in a mean maximum plasma concentration of oxycodone up to about 240 ng/ml from a mean of about 2 to about 4.5 hours after administration, and a mean minimum plasma concentration up to about 120 ng/ml from about 10 to about 14 hours after administration. | 01-10-2013 |
20130011544 | STABILIZATION OF POLYMERIC STRUCTURES - A method for stabilizing a polymeric structure against thermo-oxidative degradation is described. A polymeric core structure is provided with a skin layer that contains a skin resin in which the skin resin at least partially envelops a portion of the core structure. The skin structure then provides a barrier that thereby stabilizes the portion of the structure that is enveloped. The skin resin is made from a treated polyarylene sulfide. | 01-10-2013 |
20130183434 | MESALAZINE TABLET HAVING IMPROVED DISSOLUTION - The invention provides a method for preparing a mesalazine enteric coated tablet comprising: (i) granulating a composition comprising mesalazine, a pharmaceutically acceptable salt, or ester thereof, into mesalazine granulates; (ii) tabletting a core composition comprising the mesalazine granulates obtained in (i) to obtain a tablet core; (iii) coating the tablet core obtained in (ii) with at least an intermediate layer and an enteric coating; where the tablet core hardness is controlled to be comprised between 80 N and 105 N and the intermediate layer represents less than 2% by weight of the tablet. | 07-18-2013 |
20130266721 | Preparation of controlled drug release porous hydroxyapatite microspheres with interconnected pore channels - A process for the preparation of controlled drug release porous hydroxyapatite microspheres, in the form of granules, consisting of interconnected pore channels with high porosity. It comprises the steps of mixing nano-hydroxyapatite powder with camphene to form a homogenous mixture followed by mixing said homogenous mixture with gelatin solution to form a complex mixture. This complex mixture is dispersed in cold stirring oil in a beaker until said dispersed granules hardens to form green bodies. These green bodies are subjected to heat treatment to obtain porous hydroxyapatite microspheres, subjecting the said porous hydroxyapatite microspheres to antibiotics encapsulation. | 10-10-2013 |
20140044860 | METHODS TO INCREASE FRACTURE RESISTANCE OF A DRUG-ELUTING MEDICAL DEVICE - Methods for increasing the fracture resistance of a polymer stent's drug-polymer coating and scaffolding including applying a coating and crimping using techniques that increase the resistance to fracture in the coating layer and scaffolding and scaffolding. | 02-13-2014 |
20140186514 | DELAYED RELEASE RASAGILINE FORMULATION - Disclosed are formulations which are designed to delay release of rasagiline while maintaining specific pharmacokinetic properties. | 07-03-2014 |
20140186515 | DUAL DRUG DOSAGE FORMS WITH IMPROVED SEPARATION OF DRUGS - Drug tablets that include a prolonged-release core and an immediate-release layer or shell are prepared with a thin barrier layer of drug-free polymer between the prolonged-release and immediate-release portions of the tablet. The barrier layer is penetrable by gastrointestinal fluid, thereby providing full access of the gastrointestinal fluid to the prolonged-release core, but remains intact during the application of the immediate-release layer, substantially reducing or eliminating any penetration of the immediate-release drug into the prolonged-release portion. | 07-03-2014 |
20140199469 | SUSTAINED-RELEASE TABLET AND PROCESS FOR PREPARING THE SAME - A method for producing a sustained-release tablet having improved stability and content uniformity is provided. The method involves first preparing a core tablet by granulating, drying, milling, blending, and compressing a mixture of active and inactive ingredients. Four coating layers are applied to the core tablet: an inner layer, an enteric coating layer, an active layer, and an outer layer. The active ingredient may be a tetracycline, such as doxycycline. A sustained-release tablet prepared according to the method is also described. | 07-17-2014 |
20140272101 | MICROARRAY FOR DELIVERY OF THERAPEUTIC AGENT, METHODS OF USE, AND METHODS OF MAKING - Devices and methods for using and manufacturing microstructure arrays are described. | 09-18-2014 |
20150030757 | PERIPHERAL STENTS HAVING LAYERS - Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form. | 01-29-2015 |
20160151297 | Pharmaceutical Formulation Containing Gelling Agent | 06-02-2016 |