Class / Patent application number | Description | Number of patent applications / Date published |
424282100 | Bacterium or component thereof or substance produced by said bacterium | 48 |
20080213319 | CHEMOREPULSION OF CELLS - The present invention provides compositions and methods of controlling the direction and/or movement of migratory cells. Specifically, the invention is directed to the identification of novel chemorepellents and unimodal fugetaxins, their agonists and antagonists which alter or affect the movement of cells involved in immune, inflammatory or cancerous phenotypes. | 09-04-2008 |
20080248068 | Use of Flagellin as an Adjuvant for Vaccine - The present invention is directed to flagellin and its use as an adjuvant for vaccination. The invention can be used in vaccine formulations to improve immunity against any other antigen administered at the same localization. The antigen can be administered in the same construct as Flagellin or in any other formulation given at the same localization. As an alternative flagellin can be used to stimulate immunity against antigens expressed at a specific location. Flagellin can also be used to induce local inflammation with the purpose of creating a model for inflammation. | 10-09-2008 |
20100112013 | Adjuvant comprising oligonucleotide and non-toxic lipopolysaccharide - Disclosed is an adjuvant composition of the present invention including the oligodeoxynucleotides and the LPS-derived non-toxic polysaccharides as the major components. | 05-06-2010 |
20100322977 | BIOMATERIALS, COMPOSITIONS, AND METHODS - Embodiments exploit the ability of the organism | 12-23-2010 |
20100330128 | Method of improving immune function in mammals using lactobacillus strains with certain lipids - A method of improving immune-function in mammals using selected 3-HPA producing lactic acid bacteria with a medium chain triglyceride (MCT) oil. | 12-30-2010 |
20110002965 | IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS - Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile. | 01-06-2011 |
20120039946 | IMMUNOPOTENTIATING COMPOSITION AND PROCESS FOR PRODUCING SAME - Disclosed is an immunopotentiating composition comprising an effective immunostimulating substance which can activate natural immunity and a subsequent immunity mediated by lymphocytes without causing any damage to cells. Specifically disclosed is an immunopotentiating composition which is characterized by comprising, as an active ingredient, an immunostimulating substance produced by decomposing at least one bacterium selected from an MRE symbiotic bacteria group consisting of | 02-16-2012 |
20120045478 | METHOD AND COMPOSITIONS - A method of preparing a compound of formula (III): wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M′ is independently a mycolic acid residue including a β-hydroxy acid moiety and each S is a monosaccharide unit; the method comprising reacting one or more mycolic acids with one or more saccharide units wherein the hydroxyl group of each β-hydroxy acid moiety is protected prior to reaction with the one or more saccharide units. | 02-23-2012 |
20120076829 | ISOLATION, IDENTIFICATION AND CHARACTERISATION OF STRAINS WITH PROBIOTIC ACTIVITY, FROM FAECES OF INFANTS FED EXCLUSIVELY WITH BREAST MILK - The invention relates to probiotic micro-organisms isolated from faeces of children exclusively fed with breast milk. Said microorganisms are used in the food or pharmaceutical industry, especially for use in infant formula milk, due to their probiotic properties which have beneficial effects on the health of those ingesting them. Said microorganisms consist of | 03-29-2012 |
20120114701 | BIFIDOBACTERIUM LONGUM NCC2705 (CNCM I-2618) AND IMMUNE DISORDERS - The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defences. One embodiment of the present invention is the use of | 05-10-2012 |
20120121652 | COMPLETE LIQUID NUTRITION FOR CHILDREN AT THE AGE OF 1-10 YEARS COMPRISING PROBIOTICS - The present invention relates to the field of nutrition for children. In particular, the present invention relates to the nutritional compositions intended for children with an impaired function of the gastro-intestinal tract. One embodiment of the present invention relates to a nutritional composition to be administered to children with an impaired function of the gastrointestinal tract comprising probiotic micro-organisms. The probiotic micro-organisms may be non-replicating, for example bioactive heat treated probiotic micro-organisms. | 05-17-2012 |
20120128726 | INFANT FEEDING FORMULAS COMPRISING PROBIOTIC MICRO-ORGANISMS - The present invention relates to the field of infant nutrition. In particular, the present invention relates to infant feeding formulas comprising probiotic micro-organisms. These probiotic micro-organisms may be non-replicating probiotic micro-organisms such as bioactive heat treated probiotic micro-organisms, for example. | 05-24-2012 |
20120128727 | BACTERIAL EXPRESSION OF AN ARTIFICIAL GENE FOR THE PRODUCTION OF CRM197 AND ITS DERIVATIVES - The present invention relates to polynucleotide sequences comprising the SEQ ID N° 1 encoding CRM197 and optimised for its expression in | 05-24-2012 |
20120135044 | INSTANT THICKENER COMPRISING PROBIOTICS FOR HOT OR COLD FOODS AND BEVERAGES TO BE ADMINISTERED TO DYSPHAGIC PATIENTS - The present invention relates to the fields of hydration and nutrition for dysphagic patients. In particular, the present invention relates to thickeners comprising probiotic microorganisms and to compositions comprising such thickeners. The probiotic micro-organisms may be non-replicating probiotic micro-organisms such as bioactive heat treated probiotic microorganisms. | 05-31-2012 |
20120148628 | Compositions and methods for treatment of cancer - The present invention contemplates therapeutic constructs comprising superantigen homologues devoid of neutralizing antibodies in human sera conjugated recombinantly to costimulatory and tumor targeting molecules for treatment of cancer | 06-14-2012 |
20120148629 | NUTRITIONAL COMPOSITION COMPRISING LACTOCOCCUS STRAINS AND REDUCING ALLERGY SYMPTOMS, ESPECIALLY IN INFANTS AND CHILDREN - A complete nutritional composition comprising | 06-14-2012 |
20120201854 | MODIFIED FLAGELLIN IMPROVED TOLL-LIKE RECEPTOR 5 STIMULATING ACTIVITY - Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin. | 08-09-2012 |
20120201855 | MODIFIED FLAGELLIN IMPROVED TOLL-LIKE RECEPTOR 5 STIMULATING ACTIVITY - Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin. | 08-09-2012 |
20120201856 | Use of Mycobacterium Bovis BCG killed by Extended Freeze Drying (EFD) For Preventing or Treating Atherosclerosis | 08-09-2012 |
20120258145 | ADJUVANT FOR VACCINES, VACCINES THAT COMPRISE SAID ADJUVANT AND USES THEREOF - Adjuvant for vaccines that comprises a non-lipidated bacterial outer-membrane polypeptide (Omp), in which the bacteria may be of those of | 10-11-2012 |
20120263758 | PET FOOD COMPOSITIONS INCLUDING PROBIOTICS AND METHODS OF MANUFACTURE AND USE THEREOF - The present invention encompasses pet food compositions that include one or more probiotic microorganisms, which are useful to improve the health of companion animals. For example, the invention encompasses pet food compositions including a probiotic, for example, | 10-18-2012 |
20120276149 | METHODS FOR MODULATING BACTERIAL INFECTION - The present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria. More particularly, the present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria of the gastrointestinal (GI) tract. The present invention further relates to methods for promoting pathways induced by commensal bacteria of the GI tract that lead to Th17 differentiation, which in turn leads to localized and systemic accumulation of Th17 cells. Compositions and medicaments are also described herein that are used alleviate and/or prevent symptoms associated with diseases caused by or associated with pathogenic bacteria. Accordingly, the compositions, medicaments and methods described herein may be used to address the needs of patients or subjects that would benefit from increased Th17 cell differentiation. | 11-01-2012 |
20130011439 | Inactivated Bacterial Cell Formulation - The invention relates to the use of lactic acid-producing bacteria to boost the immune system. | 01-10-2013 |
20130039949 | IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS - Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile. | 02-14-2013 |
20130064859 | COMBINATORIAL VITAMIN D AND PROBIOTIC THERAPY FOR INFLAMMATORY BOWEL DISEASE - A method of increasing the percentage of mouse and human Tregs is provided comprising providing | 03-14-2013 |
20130149342 | COMPOSITION COMPRISING PROBIOTIC BACTERIA FOR USE IN THE TREATMENT OF IMMUNE DISORDERS - The present invention relates to a composition comprising probiotic bacteria for the treatment of pathologies associated with alterations of the immune system. In particular, the present invention relates to the use of selected probiotic bacteria for the preparation of a composition for the treatment of allergies, such as atopic dermatitis. | 06-13-2013 |
20130209517 | CANCER THERAPY - The present invention relates to a method of preventing, treating or inhibiting the development of tumors or metastases in a subject and to an immunomodulator for use in such therapy, in combination with a chemotherapeutic agent. An aspect the present invention is a method of preventing, treating, reducing, inhibiting and/or controlling the formation or establishment of metastasis of a primary neoplasia, tumor or cancer at one or more sites distinct from a primary neoplasia, tumor or cancer, in a subject intended to undergo chemotherapy, wherein the method comprises administering to the subject, a therapeutically effective amount of an antimetabolite pyrimidine analogue and an immunomodulator. | 08-15-2013 |
20130224252 | INTESTINE IMMUNOMODULATOR - The purpose of the present invention is to provide a better intestine immunomodulator. The intestine immunomodulator of the present invention comprises bacterial cells or a bacterial component of a | 08-29-2013 |
20130224253 | NON-REPLICATING PROBIOTIC MICRO-ORGANISMS PROTECT AGAINST UPPER RESPIRATORY TRACT INFECTIONS - The present invention relates to non-replicating probiotic micro-organisms and their health benefits. For example, the present invention relates to compositions comprising non-replicating probiotic micro-organisms for use in the treatment of prevention of upper respiratory tract infections and/or their symptoms. Embodiments of the present invention provide means to help parents to protect their children from such upper respiratory tract infections. | 08-29-2013 |
20130224254 | NON-REPLICATING PROBIOTIC MICRO-ORGANISMS PROTECT CHILDREN AGAINST GASTROINTESTINAL INFECTIONS - The present invention relates to non-replicating probiotic micro-organisms and their health benefits. In particular, the present invention provides a means to help parents to protect their children from gastro-intestinal infections, in particular diarrhea. One embodiment of the present invention relates to a composition comprising non-replicating probiotic micro-organisms for use in the prevention or treatment of gastrointestinal infections in children. | 08-29-2013 |
20130236497 | TREATING NEOPLASMS WITH NEUROTOXIN - The present invention provides a method of treating a cancer using a neurotoxin, preferably Botulinum toxin (“BTX”). The application of a neurotoxin around a cancer acts to decrease the contractile forces of the muscles surrounding a neoplasm which normally squeeze cancer cells through efferent channels leaving the cancer vicinity to distant sites. Also, the application of the toxin at sites distant from the cancer enhances cellular and humoral immunologic functions which further contributes to cancer cell death and spread. Following administration of botulinum toxin around and distant to a cancer, it is noticed that local, regional, and distant spread is reduced or eliminated. Immunomodulation with botulinum toxin is also valuable in treating other disease that may or may not be associated with cancers, such as viral-induced growths, viral conditions, fungal disease, chronic wounds, graft versus host disease, autoimmune disease, and HIV. | 09-12-2013 |
20130302380 | AGENT FOR INDUCING INTERFERON PRODUCTION CONTAINING LACTIC ACID BACTERIA - This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as | 11-14-2013 |
20140154290 | COMPOSITION FOR PREVENTION AND TREATMENT OF ALLERGIC AND/OR INFLAMMATORY DISEASES - A prophylactic antiallergenic composition includes at least one arabinogalactan or arabinogalactan protein. The arabinogalactan or arabinogalactan protein is isolated from a grass or corresponds in its structural arrangement to an arabinogalactan that can be isolated from a grass. | 06-05-2014 |
20140234379 | AGENT FOR INDUCING INTERFERON PRODUCTION CONTAINING LACTIC ACID BACTERIA - This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as | 08-21-2014 |
20140294900 | FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF - The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptsis is described. | 10-02-2014 |
20140335131 | PROBIOTIC PREVENTION AND TREATMENT OF COLON CANCER - Methods are provided herein for preventing, delaying the onset of or reducing the progression of colorectal tumorigenesis in a subject identified as at risk of colorectal tumorigenesis, comprising adjusting the composition of gut microbiota in the subject via administering to the subject a composition comprising | 11-13-2014 |
20140348878 | STRAIN OF EXOPOLYSACCHARIDE-SECRETING LACTOBACILLUS BREVIS AND APPLICATION THEREOF - A strain of exopolysaccharide-secreting | 11-27-2014 |
20150030637 | REDUCTION OF NON-STARCH POLYSACCHARIDES AND ALPHA-GALACTOSIDES IN SOY FLOUR BY MEANS OF SOLID-STATE FERMENTATION USING CELLULOLYTIC BACTERIA ISOLATED FROM DIFFERENT ENVIRONMENTS - The invention relates to a method for fermenting soy flour in the solid state in order to reduce non-starch polysaccharides and alpha-galactosides, said method comprising the following steps: a) preparation of the fermentation substrate; b) inoculation of the substrate with selected celluloytic bacterial strains; c) incubation; and, optionally, d) drying of the product, which generates a product with: an increase in protein of between 12 and 15% compared to non-fermented soy flour, degradation of the alpha-galactosides of more than 90% compared to non-fermented soy flour, a reduction in non-starch polysaccharides (NSPs) of between 15 and 25%, an amino acid profile similar to that of non-fermented soy flour, and immune-stimulating effects. | 01-29-2015 |
20150290255 | PHARMACEUTICAL COMPOSITION FOR TREATING CANCER - The present invention relates to increase in survival of mammals suffering from desmocollin 3 expressing cancers. | 10-15-2015 |
20150313924 | METHODS OF IMPROVING RNAI IN WELL-DIFFERENTIATED AIRWAY EPITHELIA - The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a facilitating agent followed by contacting the cell with a therapeutic RNAi agent, wherein the facilitating agent comprises a Platelet-activating factor receptor (PAFR) ligand. | 11-05-2015 |
20150374762 | IMMUNOSTIMULATION AGENT - The present invention provides | 12-31-2015 |
20160022727 | IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS - Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile. | 01-28-2016 |
20160030464 | IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS - Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile. | 02-04-2016 |
20160030494 | Network-Based Microbial Compositions and Methods - Provided are therapeutic compositions containing combinations of bacteria, for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract of a mammalian subject, and methods for use thereof. | 02-04-2016 |
20160144014 | COMPOSITIONS CONTAINING COMBINATIONS OF BIOACTIVE MOLECULES DERIVED FROM MICROBIOTA FOR TREATMENT OF DISEASE - Compositions consisting of bioactive molecules derived from the microbiota of a mammal are provided herein. When administered orally with a colonic delivery system, the compositions are useful for the prophylaxis and treatment of diseases, in particular inflammatory, autoimmune and infectious diseases. The compositions comprise combinations of small molecules and bacterial antigens formulated in colonic delivery systems. Use of the compositions results in any or all of: induction of immune tolerance; strengthening of the gut mucosal barrier integrity; reduction of inflammation; and amelioration of a disease state caused by inflammation, an autoimmune reaction or an infectious agent. | 05-26-2016 |
20160200762 | Bioactive polypeptide DELQ and preparation method as well as application thereof | 07-14-2016 |
20170232092 | METHODS AND COMPOSITIONS FOR T CELL GENERATION AND USES THEREOF | 08-17-2017 |
20190142032 | Pet Food Compositions Including Probiotics and Methods of Manufacture and Use Thereof | 05-16-2019 |