Entries |
Document | Title | Date |
20080247957 | Advanced drug delivery strategy and platform for minimally-invasive treatment of liver cancer - The present invention comprises minimally invasive methods useful in the treatment of liver cancer. The method of the present invention comprises administering to an individual with liver cancer an injectable, echogenic nanocapsule and/or microcapsule wherein the nanocapsule and/or microcapsule comprises a therapeutic agent, a targeting moiety, or a combination thereof. The method of the present invention further comprises monitoring the distribution of the nanocapsule and/or microcapsule using ultrasound. The method of the invention delivers a therapeutic agent to a liver cancer cell either by biodegradation of a nanocapsule and/or microcapsule comprising a therapeutic agent, or by altering the biodegradation of a nanocapsule and/or microcapsule using ultrasound. | 10-09-2008 |
20080286206 | Composition and Method for Medical Imaging of Body Cavities - The present invention relates to an image enhancing composition for the enhancement of contrast in a body cavity, wherein the viscosity of the composition is between 2000 and 4000 mPa·sec. It also relates to a method for enhancing contrast of an image of a body cavity, which method involves introducing one single small aliquot of an image enhancing composition into the body cavity. In another aspect, the present invention provides a high contrast image of a body cavity obtained by the method of the invention, in particular a 3-dimensional high contrast image. | 11-20-2008 |
20080311046 | Ultrasound Contrast Agent - An ultrasound contrast agent composed of at least one kind of low-boiling water-insoluble substance (with a boiling point lower than 37° C.) and at least one kind of high-boiling water-insoluble substance (with a boiling point higher than 37° C.). The former vaporizes to absorb ultrasonic energy upon application of ultrasound, thereby causing the latter to vaporize secondarily, with the resulting bubbles producing an echo image. It is less liable to bumping and hence safe. | 12-18-2008 |
20090028797 | Novel polymeric ultrasound contrast agent and methods of making thereof - The present invention provides a novel method of manufacturing nanosized polymeric echogenic contrast agents. The method of the present invention comprises a modified salting out process which results on nanosized polymeric capsules encapsulating an aqueous core that is subsequently evacuated. The compositions of the present invention can be used as contrast agents as well as to deliver therapeutic agents to specific targets. | 01-29-2009 |
20090117052 | Enhancement agent for high intensity focused ultrasound treatment and method for screening the same - The present invention discloses an enhancement agent for high intensity focused ultrasound (HIFU) treatment, which is administered to a patient before HIFU treatment and can reduce the level of EEF at the target location to be treated with HIFU. EEF is presented by the expression: EEF=ηPt/V (unit: J/mm | 05-07-2009 |
20090148385 | Ultrasound Contrast Agents For Molecular Imaging - A new type of contrast agent is described, which comprises matrix particles with a plurality of metal nanoparticles as well as the method of imaging therewith. A plurality of metal nanoparticles are encapsulated in a non-proteinaceous biocompatible or biodegradable matrix particle and/or attached to a non-proteinaceous biocompatible or biodegradable matrix particle, the matrix of the matrix particles being selected from the group consisting of a carbohydrate, a lipid, a synthetic polymer, an aqueous liquid, a surfactant and an organic liquid, or a mixture thereof. The matrix particles are biocompatible and/or biodegradable and can be coupled to targeting molecules for targeted visualization. | 06-11-2009 |
20090196827 | Drug Loaded Contrast Agents: Combining Diagnosis and Therapy - This invention provides an improvement to methods of drug loading of ultrasound contrast agents. Echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof produced by the method of the invention wherein the echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof contain at least 10% more of a drug as compared to (1) echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding drug prior to emulsifying or (2) echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding drug to lyophilized polymer microcapsules, nanocapsules, or mixtures thereof. | 08-06-2009 |
20090274628 | RECONSTITUTABLE MICROSPHERE COMPOSITIONS USEFUL AS ULTRASONIC CONTRAST AGENTS - Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugars) in specified amounts that reduce aggregation of the particles comprising the suspension. | 11-05-2009 |
20090297455 | DEVICE FOR AND A METHOD OF ACTIVATING A PHYSIOLOGICALLY EFFECTIVE SUBSTANCE BY ULTRASONIC WAVES, AND A CAPSULE | 12-03-2009 |
20100003195 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 01-07-2010 |
20100068149 | Use of nutritional compositions for preventing disorders - The present invention relates to a method for preventing and/or treating visceral adiposity and/or to alter body fat distribution by administering a certain nutritional composition to a human subject with the age between 0 and 48 months, and preventing the occurrence of diseases later in life. | 03-18-2010 |
20100086490 | GAS-FILLED MICROVESICLES WITH TARGETING LIGAND OR THERAPEUTIC AGENT - Gas-filled microvesicles comprising a boundary envelope containing a gas, wherein said microvesicles comprise: —a first component, bound to said envelope, having binding affinity for an Fc-region of an antibody; and—a second component comprising a Fc-region of an antibody, bound to said first component through said Fc-region, said second component comprising a targeting ligand or a therapeutic agent. Aqueous suspensions of said microvesicles are particularly useful in contrast enhanced ultrasound imaging. | 04-08-2010 |
20100233090 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 09-16-2010 |
20110070165 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 03-24-2011 |
20110097275 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 04-28-2011 |
20110104068 | Echogenic Coatings and Their Use in Medical Devices - The present teachings relate to echogenic coatings and medical devices coated with an echogenic coating. The echogenic coating can be prepared from a composition comprising a polymer and an effervescent agent in one or more anhydrous solvents. | 05-05-2011 |
20110135576 | DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS - Dye conjugates of template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 14 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, or Pro or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties, and are useful for cancer therapy; diagnostic imaging; for detection of tumors and other abnormalities; for photoacoustic tumor imaging, detection and therapy; and for sonofluorescence tumor imaging, detection and therapy. The various dyes forming part of these conjugates are useful over the range of 300-1200 nm, the exact range being dependent upon the particular dye. These dye conjugates of β-hairpin peptidomimetic can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy. | 06-09-2011 |
20120027688 | PREPARATION OF A LIPID BLEND AND A PHOSPHOLIPID SUSPENSION CONTAINING THE LIPID BLEND - The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent. | 02-02-2012 |
20120093731 | GAS-FILLED MICROVESICLES WITH TARGETING LIGAND OR THERAPEUTIC AGENT - Gas-filled microvesicles comprising a boundary envelope containing a gas, wherein said microvesicles comprise: —a first component, bound to said envelope, having binding affinity for an Fc-region of an antibody; and—a second component comprising a Fc-region of an antibody, bound to said first component through said Fc-region, said second component comprising a targeting ligand or a therapeutic agent. Aqueous suspensions of said microvesicles are particularly useful in contrast enhanced ultrasound imaging. | 04-19-2012 |
20120121516 | Emulsion Activatable by Ultrasounds and Method for Producing Same - The invention relates to an emulsion that can be activated by ultrasounds, comprising, in an emulsion in an aqueous solution, microparticles having a diameter of less than 10 μm and containing an active agent and a gaseous precursor in a liquid form, encapsulated by a first emulsifier. The microparticles contain nanoparticles smaller than 1 μm, in an emulsion in the gaseous precursor, each nanoparticle comprising an inner liquid that contains the active agent and is encapsulated by a second emulsifier. | 05-17-2012 |
20120128595 | PREPARATION OF A LIPID BLEND AND A PHOSPHOLIPID SUSPENSION CONTAINING THE LIPID BLEND - The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent. | 05-24-2012 |
20120237450 | Stabilized Ultrasound Contrast Agent - Provided is a particle-stabilized ultrasound contrast agentn (UCA) and methods of preparing same. Also provided is a method for preparing a lyoprotected UCA, a freeze-dried lyoprotected UCA, and a reconstituted freeze-dried lyoprotected UCA. | 09-20-2012 |
20120328529 | MICROFLUIDIC-BASED GENERATION OF FUNCTIONALIZED MICROBUBBLES FOR ULTRASOUND IMAGING AND THERAPY - A method for generating stable encapsulated bubbles and dried encapsulated bubbles comprises introducing an inner stream of a gas into a liquid-filled chamber from an exit orifice of a capillary tube; introducing a middle stream of a water immiscible liquid into the exit orifice; and introducing an outer stream of an aqueous liquid to the exit orifice, to form compound bubbles. The encapsulated bubbles are formed after converting the middle phase of compound bubbles into a shell. The stable encapsulated bubbles or the stable dried encapsulated bubbles can be used in drug delivery and for enhancing ultrasound imaging. | 12-27-2012 |
20130309174 | PREPARATION OF A LIPID BLEND AND A PHOSPHOLIPID SUSPENSION CONTAINING THE LIPID BLEND - The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent. | 11-21-2013 |
20130309175 | PREPARATION OF A LIPID BLEND AND A PHOSPHOLIPID SUSPENSION CONTAINING THE LIPID BLEND - The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent. | 11-21-2013 |
20130323177 | TUMOR-TARGETING GAS-GENERATING NANOPARTICLE, METHOD FOR PREPARING THE SAME, AND TUMOR-TARGETING NANOPARTICLE FOR DRUG DELIVERY USING THE SAME - A tumor-targeting gas-generating nanoparticle, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same relate to a tumor-targeting gas-generating nanoparticle including a polycarbonate core and a amphiphilic coat, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same. Since a tumor-targeting gas-generating nanoparticle according to the present disclosure is accumulated in the tumor tissue in large quantity and generates strong ultrasound wave signals, it can be usefully used as a contrast agent for ultrasonic imaging. | 12-05-2013 |
20130323178 | INDOCYANINE GREEN-CONTAINING PARTICLE AND CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING HAVING THE PARTICLE - Provided is the following indocyanine green (ICG)-containing particle to be used as, for example, a contrast agent for fluorescent imaging or photoacoustic imaging. The leakage of ICG from the particle in a serum is prevented and hence the particle can stably retain ICG. According to a particle characterized by having an aggregate of indocyanine green and a phospholipid, the leakage of ICG from the particle in a serum or the like is prevented and hence ICG can be stably retained in the particle. | 12-05-2013 |
20130344001 | INDOCYANINE GREEN-CONTAINING PARTICLES, PHOTOACOUSTIC-IMAGING CONTRAST AGENT INCLUDING THE SAME, AND METHOD FOR PRODUCING THE INDOCYANINE GREEN-CONTAINING PARTICLES - Indocyanine green-containing particles each include a metal oxide particle or a metal particle and an aggregate of indocyanine green. The aggregate of indocyanine green has a relative maximum absorbance at 880 nm or more and 910 nm or less. | 12-26-2013 |
20140147389 | Antigen Specific Ultrasound Contrast Medium, a Process for the Preparation Thereof and Its Uses - The present invention refers to an antigen specific echographic contrast medium for diagnostic and/or therapeutic use, a process for the preparation thereof and its uses in ultrasound diagnostic imaging and in therapy. In particular, a contrast medium according to the invention has proven to be useful in selectively carrying drugs and/or other bio-active principles into a diseased tissues and in releasing the same in site, once bond to such tissue and suitably insonated. Moreover, an echographic contrast medium according to the invention allows a differentiation of the diseased tissues from the surrounding (healthy) tissues, by conferring an improved contrastographic enhancement to the diseased tissue alone over an extended period of time. | 05-29-2014 |
20140161726 | Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents - Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension. | 06-12-2014 |
20140205542 | Perfusive Organ Hemostasis - Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs. | 07-24-2014 |
20140335024 | NANOCARRIERS FOR IMAGING AND THERAPY APPLICATIONS - Nanocarriers and methods of preparation and use of nanocarriers are presented. In some embodiments, a nanocarrier composition comprises an organic liquid comprising a plurality of nanoparticles dispersed therein; and a coating material disposed around the exterior surface of the organic liquid. Biological tissue may be imaged or treated by coming into contact with a nanocarrier composition, and, at least in some embodiments, irradiated. | 11-13-2014 |
20150023880 | PREPARATION OF A LIPID BLEND AND A PHOSPHOLIPID SUSPENSION CONTAINING THE LIPID BLEND - The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent. | 01-22-2015 |
20150093332 | TUMOR-TARGETING MULTI-MODE IMAGING METHOD FOR LIVING BODY BASED ON GOLD NANOCLUSTERS - A tumor-targeting multi-mode imaging and analyzing method for living body based on gold nanoclusters can include incubating the relevant cells with chloroauric acid and the salt solution thereof with certain concentration under physiological conditions, thereby generating gold nanoclusters. After, real-time non-invasive fluorescence imaging, Raman imaging and/or ultrasonic imaging can be used to image the tumor tissue. | 04-02-2015 |
20150118161 | ULTRASOUND CONTACT FLUID - The present invention concerns an aqueous ultrasound contact fluid comprising a pharmaceutical grade triglyceride and a pharmaceutically acceptable emulsifier and the use of said ultrasound contact fluid in an intraoperative or interventional ultrasound imaging procedure. | 04-30-2015 |
20150132227 | NOVEL ECHOGENIC CONTRAST AGENTS - Disclosed are compositions and methods for related to echogenic contrast agents. Also disclosed are methods and compositions for diagnosing eosinophilic esophagitis in a subject. Also disclosed are methods for producing a medical image of a tissue. Also disclosed are methods of monitoring the progression of eosinophilic esophagitis in a subject before, during, and after treatment. | 05-14-2015 |
20150147276 | NANOTHERAPEUTICS FOR DRUG TARGETING - The invention provides compositions and methods for targeted controlled drug release. The compositions and methods can be used for treating or imaging vascular stenosis, stenotic lesions, occluded lumens, embolic phenomena, thrombotic disorders and internal hemorrhage. | 05-28-2015 |
20150328343 | CONTRAST MEDIUM, METHOD AND KIT FOR PREPARING SAME - Provided is a contrast medium comprising at least one molecular probe and at least one optical probe on a surface of a substrate having an ultrasound imaging function. More specifically, a contrast medium having sensitivity to not only ultrasound but also light excellent in real-time imaging and resolution and having a size sufficient to travel into tissues through blood vessel can be provided by labelling an ultrasound imageable substrate with a molecular probe and an optical probe. | 11-19-2015 |
20150359751 | GAS-GENERATING NANOPARTICLE - Disclosed are gas-generating nanoparticles comprising fine-grained calcium carbonate crystals and a biocompatible polymer, the fine-grained calcium carbonate crystals being encapsulated inside the biocompatible polymer, and the diagnosis and treatment of diseases can be effectively performed at the same time by using a composition of the present disclosure. | 12-17-2015 |
20160000943 | PHOSPHOLIPID COMPOSITION AND MICROBUBBLES AND EMULSIONS FORMED USING SAME - A composition for stabilizing a fluorocarbon emulsion. That composition includes phosphatidylcholine, phosphatidylethanolamine-PEG, and a cone-shaped lipid. | 01-07-2016 |
20160250352 | SHIELDED BIOLOGIC THERAPEUTIC | 09-01-2016 |
20160250357 | MECHANISMS INVOLVED IN THE FORMATION OF BIOCOMPATIBLE LIPID POLYMERIC PATCHY PARTICLES | 09-01-2016 |
20160374774 | METHOD FOR MAKING HYDROGEL MARKERS - A hydrogel marker is placed under stress during its curing stage, in one embodiment, by application of an externally applied force. The stress may also be induced during or after the dehydration process. The direction of the externally applied force increases the length, width, depth, or radial extent of the marker. The elastic limit of the marker is exceeded when the external force is applied so that the marker substantially retains its stressed size and shape when the externally applied force is removed. When the stretched or otherwise deformed dehydrated marker is hydrated, it substantially returns to the configuration it had prior to its dehydration and prior to the application of the externally applied force. | 12-29-2016 |