ZIMMER ORTHOBIOLOGICS, INC. Patent applications |
Patent application number | Title | Published |
20130330415 | METHOD OF OBTAINING VIABLE SMALL TISSUE PARTICLES AND USE FOR TISSUE REPAIR - The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extracellular molecules and are sized, in certain embodiments, to be smaller than about 1 mm. Another aspect of the inventive tissue particles is the large percentage of viable cells. In certain embodiments, the tissue particles are made from cartilage and the composition may also contain additives such as adhesives, solutions, and bioactive agents. | 12-12-2013 |
20120263683 | PREPARATION FOR REPAIRING CARTILAGE TISSUE, ESPECIALLY ARTICULAR CARTILAGE DEFECTS - Provided herein are preparations for repairing enchondral or osteochondral defects ( | 10-18-2012 |
20120183586 | METHOD OF OBTAINING VIABLE SMALL TISSUE PARTICLES AND USE FOR TISSUE REPAIR - The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extracellular molecules and are sized, in certain embodiments, to be smaller than about 1 mm. Another aspect of the inventive tissue particles is the large percentage of viable cells. In certain embodiments, the tissue particles are made from cartilage and the composition may also contain additives such as adhesives, solutions, and bioactive agents. | 07-19-2012 |
20120179173 | MEDICAL DEVICES AND METHODS FOR CUTTING AND SUTURING BIOLOGICAL TISSUE - Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided. | 07-12-2012 |
20120121660 | BONE VOID FILLERS - A bone void filler composition is described containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier component that contains a collagenous material. The bone void filler composition may be in the form of a sponge or in the form of a paste or putty used to form a sponge or is obtained from particulated sponge, or that forms after a sponge is rehydrated. A pre-mixed bone void filler composition is described containing the acidic mineral component or the lower alkyl carboxylate source; the osteoinductive component; and a biologically acceptable carrier component that contains a liquid carrier. Methods of making and using the compositions are also described. The ratio of demineralized bone component to acidic mineral component may range from about 0.5:1 to about 80:1. | 05-17-2012 |
20120020932 | THERMOSENSITIVE HYDROGEL COMPOSITION AND METHOD - A hydrogel-forming composition is provided that comprises an extracellular matrix protein, hyaluronic acid, and a thermosensitive biocompatible polymer such as methylcellulose. The hydrogels can provide a therapeutic effect; further, the hydrogels may comprise an optional therapeutic agent such as cells or a pharmaceutical composition. The composition may be injected to an area in need of treatment by the therapeutic agent. The composition may form a gel at about 37° C., such that the gel maintains the therapeutic agent in the area of the body in need of such treatment. | 01-26-2012 |
20120003192 | HYDROGEL-FORMING COMPOSITION COMPRISING PROTEIN AND NON-PROTEIN SEGMENTS - A hydrogel-forming composition is formed from a protein polymer derivative having a plurality of cross-linkable units depending therefrom, and a non-protein polymer derivative having a plurality of cross-linkable units depending therefrom, said non-protein polymer derivatives having hydrolysable units disposed between the polymer backbone of said derivative and at least some of said cross-linkable units. The use of a combination of protein and non-protein polymers provides for biodegradability of the hydrogel by hydrolysis of the hydrolysable units and/or enzymatic degradation of the proteins, along with mechanical properties such as strength and elasticity. | 01-05-2012 |
20120003176 | HYDROGEL-FORMING COMPOSITION COMPRISING NATURAL AND SYNTHETIC SEGMENTS - A hydrogel composition is formed from a natural polymer derivative having a plurality of cross-linkable units depending therefrom, and a synthetic polymer derivative having a plurality of cross-linkable units depending therefrom, said natural and synthetic polymer derivatives having hydrolysable units disposed between the polymer backbone of said derivative and at least some of said cross-linkable units. The use of a combination of natural and synthetic polymers provides for biodegradability of the hydrogel, along with mechanical properties such as strength and elasticity. | 01-05-2012 |
20100196489 | BONE GROWTH PARTICLES AND OSTEOINDUCTIVE COMPOSITION THEREOF - A biocompatible synthetic bone growth composition comprising a fibrillar collagen component and a calcium phosphate component. The composition is formed into particles, and then formed into a unitary article that may be provided at the site of a skeletal defect. An osteoinductive component may be further added, either before or after forming the unitary article. The composition may be formulated as a paste or putty and facilitates bone growth and/or repair. | 08-05-2010 |
20090136929 | NOVEL IN VITRO METHOD OF QUANTIFYING DEMINERALIZED BONE OSTEOINDUCTIVITY - The present invention provides an in vitro method for determining the osteoinductive potential of a biomaterial. In particular, the method measures the expression of osterix by osteoblast progenitor cells incubated with the biomaterial. In various embodiments, the biomaterial is demineralized bone (DMB) and the progenitor cells are incubated with DMB or proteins extracted from DMB. | 05-28-2009 |
20090054906 | MEDICAL DEVICE AND METHOD FOR DELIVERING AN IMPLANT TO AN ANATOMICAL SITE - A medical device and method for providing an implant to an anatomical site are disclosed. The medical device generally comprises a sleeve having first and second ends, a cutting frame coupled to the second end, and a rod received in an inner bore of the sleeve. The cutting frame defines a guide configured to direct a cutting tool for reciprocal motion along a cutting plane. When the implant is positioned within the inner bore, the rod and sleeve are used to gauge a depth of the anatomical site and to advance a portion of the implant beyond the cutting plane. The implant may then be cut to an appropriate size to fit the anatomical site. | 02-26-2009 |
20090030431 | MEDICAL DEVICES AND METHODS FOR CUTTING AND SUTURING BIOLOGICAL TISSUE - Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided. | 01-29-2009 |
20080306610 | TISSUE PROCESSING FOR NONIMMUNOGENIC IMPLANTS - Methods for processing tissues to render them suitable for implantation, e.g. in an orthopedic site. Tissues are rendered substantially acellular and substantially nonimmunogenic by exposure to processes that result in cell lysis, increasing permeability of the extracellular matrix, degrading the debris from lysis, and removing the debris. Methods of forming tissue implants, kits for processing tissue implants, and methods of using tissue implants are also disclosed. | 12-11-2008 |
20080294270 | DIFFERENTIALLY PROCESSED TISSUE AND PROCESSING METHODS THEREOF - A method of preparing an implantable biological device having a first tissue part and a second tissue part includes exposing the first tissue part to a first preparation method and preventing exposure of the second biological tissue part to the first preparation method. Preventing exposure of the second biological tissue part to the first preparation method may be achieved using an embedding technique, a coating technique, a covering technique, or physical isolation. The method may further include exposing the second tissue part to a second preparation method and preventing exposure of the first biological tissue part to the second preparation method. An apparatus for preparing an implantable biologic device includes an enclosure having first and second chambers separated by a partition member wherein a substantial portion of the first tissue part is within the first chamber and a substantial portion of the second tissue part is within the second chamber. | 11-27-2008 |