University of Virginia Patent Foundation, d/b/a University of Virginia Licensing & Ventures Group Patent applications |
Patent application number | Title | Published |
20130330274 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING CANCER - Macrophages within the tumor microenvironment, also called tumor associated macrophages (TAMs) have been shown to play a major role in the growth and spread of many types of cancer. Cancer cells produce cytokines that cause the macrophages to differentiate into an M2 subtype. We have designed a mannosylated liposome (MAN-LIPs) and successfully showed it to accumulate in TAMs in a mouse model of pulmonary adenocarcinoma. These liposomes are loaded with | 12-12-2013 |
20130317070 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS - The invention provides for the use of antimicrobial chemical entities based on a nitrothiazolide backbone that exhibit anti-mycobacteria activity, including the mycobacterium causing tuberculosis. Multiple compounds were synthesized and screened for anti-tuberculosis activity. Disclosed herein are a series of compounds with anti-tuberculosis activity, including six leads that completely inhibited bacterial growth at 5 micrograms per ml or less. Three of these compounds were tested to determine MIC and these ranged between 1 and 4 micrograms per ml against both drug susceptible | 11-28-2013 |
20130236425 | COMPOSITIONS AND METHODS FOR CXCR4 SIGNALING AND UMBILICAL CORD BLOOD STEM CELL ENGRAFTMENT - The present invention provides for enhancing engraftment by co-infusing at least two partially HLA matched umbilical cord blood (“UCB”) units. The invention further provides for positive C3a mediated priming on responsiveness to doses of SDF-1 and C3a induced incorporation of CXCR4 in membranes in HSC and progenitors. The invention further provides for enhancing the homing of UCB HSC and progenitors via the SDF-1/CXCR4 pathway and that C3a and LL-37 are useful for this method. It is also disclosed herein that fragments of C3a (e.g., des-Arg) are effective in the methods of the invention, including enhancing homing of HSPCs to BM. The invention further encompasses the disclosure herein of NFAT1 regulation post-transcriptionally by both mir-184 and IFN-γ. The present invention further provides for measuring and using differences between UCB and adult CD4+/45RA+ T-cells as a means of defining strategies to enhance optimal allogeneic stem cell transplantation outcomes. The present invention further provides methods for maintaining IL-2 production in the absence of NFAT1 normal protein levels. | 09-12-2013 |
20130231538 | DEVICE AND METHOD FOR SAFELY EXPANDING MINIMALLY INVASIVE SURGICAL INCISIONS - An insertion tongue of the retractor device may be pushed into the subject through the trocar incision, along one side of the organ. The tip of the insertion tongue pushes the impacted organ and its endoscopic recovery bag slightly away from the cavity wall. A scalpel is passed through the insertion guide with the tip of the scalpel blade in the retention guide on the back of the insertion tongue, and with the sharp side of the scalpel blade facing away from the organ and from the tongue of the retractor device. The scalpel is then passed down through the cavity wall, with its tip in the retention guide, while tension on the retractor device handle away from the organ, and gentle outward traction on the organ (and bag) permits removal of the organ (and bag) as soon as the opening is just large enough to allow it. | 09-05-2013 |
20130179067 | Method, System and Computer Program Product for Optimizing Route Planning Digital Maps - A system for digital network map development and maintenance. The system provides for optimizing digital network maps that serve as the reference basis for location-based systems such as, but not limited to, route guidance, multi-modal transportation system monitoring, location-based consumer applications, and vehicle fleet administration. The system provides the ability to develop and maintain digital route maps derived at least in part from data on the routes that drivers or users actually travel to update a digital map. For a route defined between two or more points, costs may be assigned to each road segment. As such, given a collection of route preferences, an algorithm is provided that is capable of generating an optimized route planning digital map by finding and assigning a set of costs to road segments in a way that is consistent with these preferences. | 07-11-2013 |
20130136729 | COMPOSITIONS AND METHODS FOR TARGETING AND TREATING DISEASES AND INJURIES USING ADENO-ASSOCIATED VIRUS VECTORS - The present application discloses compositions and methods useful for targeting and treating injured or diseased muscle, including cardiac and skeletal muscle. Disclosed herein are adenoviral vectors modified to contain enhancers, promoters, and genes to target muscle with high efficiency and to induce tissue specific gene expression of transgenes. | 05-30-2013 |
20130131615 | Method Suction Device and Related Method Thereof - A system or device for providing medical suction, particularly for intubating patients, wherein the system or device helps prevent clogging from solids dispersed in the liquid to be suctioned. This device will allow the user to effectively clear an airway or other region of the patient while minimizing the occurrence of clogs and providing for the effective and expedited unclogging of the device without the necessity of removing the device from the patient or requiring two hands to unclog. | 05-23-2013 |
20130113063 | HIGH BANDWIDTH, MONOLITHIC TRAVELING WAVE PHOTODIODE ARRAY - The monolithic application of a high speed TWPDA with impedance matching. Use of the high speed monolithic TWPDA will allow for more efficient transfer of optical signals within analog circuits and over distances. | 05-09-2013 |
20130058157 | MAGNETIC RANDOM ACCESS MEMORY DEVICE - The present invention proposes an electronic memory device comprising a memory line including a memory domain. The memory line may contain a number of memory domains and a number of fixed domains, wherein each memory domain stores a single binary bit value. A multiferroic element may be disposed proximate to each memory domain allowing the magnetization of the memory domain to be changed using a spin torque current, and ensuring the stability of the magnetization of the domain when it is not being written. The domain boundary between the memory domain and one of its adjacent fixed domains may thereby be moved. An antiferromagnetic element may be disposed proximate to each fixed domain to ensure the stability of the magnetization of these. The value of each memory domain may be read by applying a voltage to a magnetic tunnel junction comprising the memory domain and measuring the current flowing through it. | 03-07-2013 |
20130020297 | SYSTEMS AND METHODS OF LASER TEXTURING OF MATERIAL SURFACES AND THEIR APPLICATIONS - The surface of a material is textured and by exposing the surface to pulses from an ultrafast laser. The laser treatment causes pillars to form on the treated surface. These pillars provide for greater light absorption. Texturing and crystallization can be carried out as a single step process. The crystallization of the material provides for higher electric conductivity and changes in optical and electronic properties of the material. The method may be performed in vacuum or a gaseous environment. The gaseous environment may aid in texturing and/or modifying physical and chemical properties of the surfaces. This method may be used on various material surfaces, such as semiconductors, metals and their alloys, ceramics, polymers, glasses, composites, as well as crystalline, nanocrystalline, polycrystalline, microcrystalline, and amorphous phases. | 01-24-2013 |