University of Utah Patent applications |
Patent application number | Title | Published |
20150221124 | ITERATIVE RECONSTRUCTION OF IMAGE DATA IN CT - A method and calculation unit are disclosed for reconstructing an image from measured projection data. In an embodiment, the method includes reconstructing an initial image from the projection data via back-projection; dividing the initial image into contiguous blocks of voxels; defining groups of voxels, wherein each group is defined by selecting one voxel from each block, each voxel having the same position relative to the other voxels within its block; updating the voxel values for all voxels within one group by minimizing a function consisting of a weighted sum of a first term representing the geometry of the data acquisition process, and a second regularization term; and repeating the updating of the voxel values for all voxels within one group until all groups have been updated at least once. | 08-06-2015 |
20150065495 | SUBSTITUTED- 1H-BENZO[D]IMIDAZOLE SERIES COMPOUNDS AS LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1) INHIBITORS - The present invention provides compounds which are useful as inhibitors of lysine-specific demethylase 1 (“LSD1”). The present invention also relates to pharmaceutical compositions containing these compounds. The present invention also relates to a method for preparing these compounds. The present invention also relates to a method of treating a mammalian disorder in which LSD1 levels are elevated by administering these compounds and compositions to a patient in need thereof. The present invention also relates to a method for decreasing histone demethylase activity in a mammal comprising administering to the mammal an effective amount of these compounds and compositions. | 03-05-2015 |
20150036117 | MASKLESS NANOIMPRINT LITHOGRAPHY - A method for creating a nanoimprint lithography template includes exposing ( | 02-05-2015 |
20140311066 | EMERGENCY UTILITY CONNECTION FOR MISSION CRITICAL FACILITIES - Systems and methods which utilize a connection panel having multiple connection types in order to connect supplemental or emergency utility services to a building are provided. The connection panel may be pre-fabricated or engineered to simplify construction and subsequent utility connections. Further, embodiments may dispose standardized utility connections on the connection panel. Upon connecting supplemental sources to the connection panel, embodiments may also include switching systems, such as valves, electrical switches, etc., configured to connect the supplemental sources to infrastructure located in the building. | 10-23-2014 |
20140298921 | HIGH-RESOLUTION FLEXIBLE TACTILE IMAGER SYSTEM BASED ON FLOATING COMB ELECTRODE - A flexible tactile imager includes an array of sensing cells that measure shear force and normal force. The sensing cells include a first sub-cell and a second sub-cell. Each sub-cell includes multi-fingered capacitors configured to measure shear force in a first or second direction and to measure the normal force. The multi-fingered capacitors include a flexible printed circuit board, a comb-like fingered sense electrode and drive electrode patterned on a layer of the flexible printed circuit board, a deformable dielectric material positioned above the comb-like fingered sense and drive electrodes, the comb-like fingered floating electrode patterned above the deformable dielectric material, a first capacitance formed between the comb-like fingered sense electrode and the comb-like fingered floating electrode, and a second capacitance formed between the comb-like fingered drive electrode and the comb-like fingered floating electrode. | 10-09-2014 |
20140186314 | PURE POPULATIONS OF ASTROCYTE RESTRICTED PRECURSOR CELLS AND METHODS FOR ISOLATION AND USE THEREOF - An isolated, pure homogeneous population of mammalian astrocyte restricted precursor cells which is CD44 immunoreactive and which generate astrocytes but not oligodendrocytes is provided. Methods for isolating and using these mammalian astrocyte restricted precursor cells are also provided. | 07-03-2014 |
20140163017 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS - In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 06-12-2014 |
20140160569 | Apparatus and Methods for Reducing Frequency or Severity of Photophobic Responses or Modulating Circadian Cycles - The present disclosure describes systems, methods, and apparatus for reducing the frequency and/or severity of photophobic responses or for modulating circadian cycles by controlling light exposure to melanopsin ganglion cells in a retina over the action potential spectrum of the melanopsin cells of the human eye and a visual spectral response of the human eye. Embodiments of an optical filter are described. In one embodiment an optical filter may be configured to transmit less than a first amount of light weighted across the action potential spectrum of the melanopsin cells and to transmit more than a second amount of light weighted across the visual spectral response. Methods of manufacturing optical filters are also described. | 06-12-2014 |
20140021982 | NANOELECTROMECHANICAL LOGIC DEVICES - Nanoelectromechanical logic devices can include a plurality of flexible bridges having control and logic electrodes. Voltages applied to control electrodes can be used to control flexing of the bridges. The logic electrodes can provide logical functions of the applied voltages. | 01-23-2014 |
20130208497 | INFUSION LINE IDENTIFICATION LIGHTING SYSTEM - An IV line identification system enables ready identification of an IV line and its associated fluid source and output from other IV lines with their fluid sources and outputs. The IV line identification system includes lights that are coupled to a specific IV line. The lights can identify specific locations on the IV line, such as an entry end by an IV bag and an output end by a needle or port associated with a patient. The lights can also identify the portions of the IV line that enter and exit a pump. The lights can also be selectively turned on when a specific IV line needs to be identified, and turned off when the IV line does not need to be individually identified. The lights may be colored to distinguish between the lights associated with another IV line. | 08-15-2013 |
20130183766 | OPTOELECTRICAL VAPOR SENSING - A chemical sensor can comprise a nanofiber mass of p-type nanofibers having a HOMO level greater than −5.0 eV. Additionally, the chemical sensor can comprise oxygen in contact with the p-type nanofibers. Further, the chemical sensor can comprise a pair of electrodes in electrical contact across the nanofiber mass, where the p-type nanofibers conduct an electric current that decreases upon contact with an amine compound. | 07-18-2013 |
20130164745 | Methods for Assessing Risk for Cardiac Dysrythmia in a Human Subject - The present invention relates to methods for assessing the risk of a patient for developing a potentially fatal cardiac dysrhythmia and for diagnosing Andersen's Syndrome. A tissue sample from a patient is obtained and the DNA or proteins of the sample isolated. From the DNA and protein isolates the sequence of the KCNJ2 gene or the Kir2.1 polypeptide can be obtained. The KCNJ2 gene or the Kir2.1 can be screened for alteration as compared to the wile-type sequence. An alteration in a copy of the KCNJ2 gene or a Kir2.1 polypeptide indicates that the patient has a high risk for developing a cardiac dysrhythmia and can be diagnosed with Andersen's Syndrome. The invention also related to isolated nucleic acid molecules with one or more alterations as compared to the wild-type sequence. | 06-27-2013 |
20130130398 | SENSORS AND METHODS FOR DETECTING PEROXIDE BASED EXPLOSIVES - Methods, compositions, and systems for detecting explosives is disclosed and described. A sensor for detecting explosives can comprise a porous hydrophilic material modified with a titanium oxo compound having the following structure (I) where L is a ligand. Additionally, the porous hydrophilic material can be capable of detecting hydrogen peroxide vapor by complexing the titanium oxo compound and the hydrogen peroxide to provide a color change. | 05-23-2013 |
20120310863 | GENE-SPECIFIC PREDICTION - A gene-specific prediction tool for classifying and interpreting gene tests is described. The prediction tool includes a classifier trained and tested using databases of gene variants and their known phenotypes. The classifier uses differences between features of amino acids in obtaining attributes used to perform classification and generate predictions, including for benign and pathologic outcomes, for uncertain gene variants. | 12-06-2012 |
20120310539 | PREDICTING GENE VARIANT PATHOGENICITY - A computer-implemented, gene-specific prediction tool for classifying and interpreting gene tests is described. The prediction tool includes a predictor using a consensus framework. The predictor employs a weighted metric of existing and complementary prediction algorithms and calculated reference intervals of disease outcomes to calculate a consensus score used in interpreting gene tests. | 12-06-2012 |
20120149944 | FLUID-SPARGED HELICAL CHANNEL REACTOR AND ASSOCIATED METHODS - A method of reacting compounds can include directing a liquid into a helical constrained flow ( | 06-14-2012 |
20120038468 | MULTIDIRECTIONAL CONTROLLER WITH SHEAR FEEDBACK - A multidirectional control system with shear feedback, comprising at least one stationary body, a plurality of tactors disposed within the at least one movable body or the at least one stationary body. In some embodiments, a moveable body is included, such that the tactors have at least one degree of freedom of motion with respect to the stationary body or the moveable body within which they are disposed and are operable to engage target areas of a user's skin; and a plurality of actuators capable of moving the tactors. | 02-16-2012 |
20110306976 | BONE PLATE AND KEEL SYSTEMS - Systems and methods for stabilizing portions of bone are provided. In some aspects, a bone plate system includes a plate configured to be fastened to at least one bone portion. The plate includes a keel slot and a locking assembly. The bone plate system also includes a keel configured to extend into the at least one bone portion through the keel slot. The locking assembly is configured to substantially prevent the keel from dislodging from the plate when the keel extends into the at least one bone portion through the keel slot. | 12-15-2011 |
20110278000 | GEOTHERMAL WELL DIVERSION AGENT FORMED FROM IN SITU DECOMPOSITION OF CARBONYLS AT HIGH TEMPERATURE - A method of selectively blocking fractures in a subterranean formation by injecting a diversion agent into the well is disclosed. According to one embodiment, the method comprises injecting a diversion agent into a subterranean formation to form an alkaline-earth carbonate precipitate from decomposition of a carbonyl compound, wherein the diversion agent includes the carbonyl compound and an alkaline-earth halide salt. | 11-17-2011 |
20110215888 | WIRELESS CONTROL OF MICROROBOTS - Wireless control of a microrobot can be performed using a magnetic field originating from a localized control magnet source relative to a body into which the microrobot is placed. Torque forces which contribute to rotation (and propulsion) of the microrobot can overcome magnetic forces which produce attraction or repulsion between the microrobot and the control magnet. | 09-08-2011 |
20110206226 | OFFENDING FREQUENCY SUPPRESSION IN HEARING AIDS - Adaptive notch filters can be used to estimate offending frequencies caused by feedback within a hearing aid system. The offending frequencies can be suppressed by filtering. Offending frequencies can be identified based on variability of the adaptive notch filter parameters. | 08-25-2011 |
20110169404 | TRAVELING WAVE ELECTRON DEVICE WITH MEMBRANE-SUPPORTED SLOW WAVE CIRCUIT - A traveling wave device includes a slow wave circuit supported by a dielectric membrane. The dielectric membrane can have a thickness substantially smaller than a wavelength of operation of the traveling wave device. | 07-14-2011 |
20110168530 | NEMS SWITCHES, LOGIC DEVICES, AND METHODS OF MAKING SAME - Nanoelectromechanical devices use a cantilevered beam supported by a base. The cantilevered beam is constructed with a nanoscale gap (e.g., less than 10 nm) separating the cantilevered beam from an electrical structure. A low voltage (e.g., less than 2 volts) applied to the cantilevered beam can cause the beam to bend and make contact with the electrical structure. High switching speeds (e.g., less than 10 ns) can be provided. The electrical structure can be a second cantilevered beam or another structure. | 07-14-2011 |
20110087295 | BONE FIXATION SYSTEMS - Systems and methods for stabilizing and/or compressing portions of bone are provided. In some aspects, a bone plate system may comprise a plate having a bone engaging surface. The plate may be fastened to two bone portions having a joint line therebetween. The system may also include a keel projecting from the bone engaging surface. The keel may extend into the bone portions and span the joint line when the plate is fastened to the bone portions. In some aspects, a ratio of an average thickness of the plate to an average width of the plate may be less than or equal to about 0.11. | 04-14-2011 |
20110087229 | BONE FIXATION AND COMPRESSION SYSTEMS - Systems and methods for stabilizing and/or compressing portions of bone are provided. In some aspects, a bone plate system may comprise a plate having a bone engaging surface. The plate may be fastened to two bone portions having a joint line therebetween. The system may also include a keel projecting from the bone engaging surface. The keel may extend into the bone portions and span the joint line when the plate is fastened to the bone portions. In some aspects, a ratio of an average thickness of the plate to an average width of the plate may be less than or equal to about 0.11. | 04-14-2011 |
20100217268 | INTERVERTEBRAL MILLING INSTRUMENT - An intervertebral milling instrument for removing calcified fibrous cartilage (CFC) from adjacent vertebrae during spinal fusion or spacer implantation surgery. The milling instrument includes a grinding wheel carried within a guide housing sized to fit closely into the intervertebral space, and to expose the grinding wheel on opposite sides thereof for controlled removal of CFC layers from adjacent cortical end plates. The grinding wheel is rotatably driven as by attachment to a surgical drill, preferably to include saline supply to and suction removal from the grinding site. The controlled removal of CFC layers is limited to about 100 to about 250 microns, thereby avoiding exposing the cortical end plates without excessive bone removal. The instrument is conveniently provided in a kit having multiple guide housings and associated grinding wheels of different sizes to fit into different intervertebral spaces. | 08-26-2010 |
20100173937 | USE OF TETRAKIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS - Provided are methods of modulating, treating, reversing and/or preventing pain using tetrakis quaternary ammonium compounds, especially regarding pain of central and/or peripheral origin and/or pain which is nociceptive, neuropathic, somatic, visceral, and/or inflammatory in nature. | 07-08-2010 |
20100152864 | OSSEOINTEGRATED IMPLANT WITH ELECTRICAL STIMULATION - An osseointegrated implant for an amputee includes a surgically implanted post-shaped orthopedic implant rigidly supported by patient bone, wherein the implant protrudes through overlying stump tissue to an external location for suitable attachment to a prosthetic limb or the like. A non-invasive electrical stimulation system provides controlled electrical stimulation at the implant-bone interface for achieving rapid and secure fixation by osseointegration in a significantly reduced rehabilitation time. The electrical stimulation system utilizes at least one and preferably multiple electrodes mounted externally onto the patient in close proximity to the implant-bone interface, with an external portion of the implant providing a second electrode. In one preferred form, the implant comprises a base structure of titanium or titanium alloy or the like, coated with a thin film of a highly conductive substance such as gold for improved electrical conductivity. | 06-17-2010 |
20100102815 | DYNAMIC COMPOSITE GRADIENT SYSTEMS FOR MRI - A composite gradient system is described, including a body gradient system and an insert gradient system, in which the body gradient system and the insert gradient system can be driven independently and simultaneously. The composite gradient system can provide an operator with the flexibility of imaging a subject using the body gradient system alone, the insert gradient system alone, or both gradient systems simultaneously, and therefore enjoy the advantages of each gradient system. In some embodiments, the body gradient system and the insert gradient system may be driven concurrently during an imaging sequence to produce composite magnetic field gradients having high amplitude and/or fast slew rate, resulting in high image resolution and/or fast image acquisition. In some embodiments, a subject may be imaged using the body gradient system alone while leaving the insert gradient system in place. | 04-29-2010 |
20100094120 | PREDICTING EFFICACY OF PSYCHIATRIC TREATMENT - Methods and systems are described for determining, in a patient that suffers from a mood disorder (e.g., depression), a propensity of the patient to manifest reduced symptoms or levels of indicators of the mood disorder in response to a psychiatric treatment. This can involve determining levels of a marker (e.g., a metabolite) indicative of a brain bioenergetic state of the patient that is predictive of whether the patient will response favorably to an antidepression treatment. Such bioenergetic state markers, tending to normalize in response to antidepression therapy, can include, e.g., a pH, a magnesium level, and a phosphorus level. Brain levels of such markers can be determined by, e.g., | 04-15-2010 |
20090313891 | PI-CONJUGATED HEAVY-METAL POLYMERS PARTICULARLY SUITED TO HYDROPONIC APPLICATIONS - A class of organic light-emitting diodes (OLEDs) emit light tailored to the absorption spectra of growing plants. Upon photoexcitation, the OLEDs generate light in both the blue-green and red regions of the visible spectrum. A heavy metal atom present in the π-conjugated polymer chain (such as platinum and/or iridium) acts via the spin-orbit coupling mechanism to cause an enhancement of the ratio of fluorescent to phosphorescent emission to be of approximately equal strength. These two emission bands overlap the absorption spectra of common plants grown under hydroponic conditions. | 12-24-2009 |
20090310332 | PI-CONJUGATED HEAVY-METAL POLYMERS FOR ORGANIC WHITE-LIGHT-EMITTING DIODES - A polymer mixture emits a broad spectrum of visible light that appears white or near-white in the aggregate. The polymer mixture comprises two (or more) components in the active layer. A heavy atom, such as platinum and/or iridium, present in the backbone of the mixture acts via a spin-orbit coupling mechanism to cause the ratio of fluorescent to phosphorescent light emission bands to be of approximately equal strength. These two broad emissions overlap. resulting in an emission spectrum that appears to the eye to be white. | 12-17-2009 |
20090262950 | MULTI-CHANNEL ACOUSTIC ECHO CANCELLATION SYSTEM AND METHOD - Techniques for multi-channel acoustic echo cancellation include adaptive filtering. An adaptive filter can use a lattice predictor of order M coupled to an adaptive LMS/Newton filter of length N, wherein M10-22-2009 | |
20090220567 | Pure Populations of Astrocyte Restricted Precursor Cells and Methods for Isolation and Use Thereof - An isolated, pure homogeneous population of mammalian astrocyte restricted precursor cells which is CD44 immunoreactive and which generate astrocytes but not oligodendrocytes is provided. Methods for isolating and using these mammalian astrocyte restricted precursor cells are also provided. | 09-03-2009 |
20090005316 | ALPHA-CONOTOXIN MII ANALOGS - The invention relates to novel conopeptides and/or novel uses of conopeptides. The conopeptides of the invention are analogs of α-Conotoxin MII that are selective for α6-containing nAChRs as described herein. | 01-01-2009 |
20080308816 | TRANSISTORS FOR REPLACING METAL-OXIDE SEMICONDUCTOR FIELD-EFFECT TRANSISTORS IN NANOELECTRONICS - Junction field effect transistors (JFETs) are shown to be a viable replacement for metal oxide semiconductor field effect transistors (MOSFETs) for gate lengths of less than about 40 nm, providing an alternative to the gate leakage problems presented by scaled down MOSFETs. Integrated circuit designs can have complementary JFET (CJFET) logic cells substituted for existing MOSFET-based logic cells to produce revised integrated circuit designs. Integrated circuits can include JFETS where the channel comprises a wide bandgap semiconductor material and the gate comprises a narrow bandgap semiconductor material. Mixtures of JFET and MOSFET transistors can be included on an integrated circuit design. | 12-18-2008 |
20080273632 | Estimation of Log-Likelihood Using Constrained Markov-Chain Monte Carlo Simulation - Log likelihood ratios for data bits transmitted in a multi-dimensional signal are estimated using multiple Markov chain Monte Carlo simulations (MCMC). The MCMC simulations can include constraining symbols based on a most-likely symbol to improve the likelihood of finding distances for non-most-likely symbols. The log likelihood ratios can be calculated based on distances of the most-likely symbol and the non-most-likely symbols. | 11-06-2008 |
20080220430 | Methods for assessing risk for cardiac dysrythmia in a human subject - The present invention relates to methods for assessing the risk of a patient for developing a potentially fatal cardiac dysrhythmia and for diagnosing Andersen's Syndrome. A tissue sample from a patient is obtained and the DNA or proteins of the sample isolated. From the DNA and protein isolates the sequence of the KCNJ2 gene or the Kir2.1 polypeptide can be obtained. The KCNJ2 gene or the Kir2.1 can be screened for alteration as compared to the wile-type sequence. An alteration in a copy of the KCNJ2 gene or a Kir2.1 polypeptide indicates that the patient has a high risk for developing a cardiac dysrhythmia and can be diagnosed with Andersen's Syndrome. The invention also related to isolated nucleic acid molecules with one or more alterations as compared to the wild-type sequence. | 09-11-2008 |