UNIVERSITY OF UTAH RESEARCH FOUNDATION Patent applications |
Patent application number | Title | Published |
20160129111 | METHODS FOR DELIVERING AN ANTI-CANCER AGENT TO A TUMOR - Described herein are methods for delivering an anti-cancer agent to a tumor in a subject. The method involves
| 05-12-2016 |
20160083522 | Arginine-Grafted Bioreducible Polymer Systems and Use in Treatment of Cardiac Conditions - phEPO/ABP polyplexes and methods for the use thereof are disclosed and described. In one embodiment, a phEPO/ABP polyplex may be administered to a subject in a therapeutically effective amount to treat or prevent a cardiac condition. Administration may 5 be made, in some aspects, by intramyocardial injection of a composition or solution containing the phEPO/ABP polyplex. | 03-24-2016 |
20160077092 | METHODS FOR ANALYSIS OF FREE AND AUTOANTIBODY-BOUND BIOMARKERS AND ASSOCIATED COMPOSITIONS, DEVICES, AND SYSTEMS - The present invention provides methods, compositions, and kits associated with analyzing, enriching, and/or isolating a biomarker or analyte in a biological sample. In one aspect, for example, a method for determining a concentration of a biomarker in a biological sample can include binding any unbound biomarker with an antibody specific for the biomarker to form antibody-bound biomarker, enriching the antibody-bound biomarker and any endogenous autoantibody-bound biomarker to form an enriched fraction, identifying the biomarker in the enriched fraction, and determining the concentration of the biomarker in the biological sample. In one aspect, the concentration of the biomarker is derived from initially unbound biomarker and autoantibody-bound biomarker in the biological sample. | 03-17-2016 |
20160074942 | PRODUCTION OF SUBSTANTIALLY SPHERICAL METAL POWDERS - A method for producing a substantially spherical metal powder is described. A particulate source metal includes a primary particulate and has an average starting particle size. The particulate source metal is optionally ball milled and mixed with a binder in a solvent to form a slurry. The slurry is granulated to form substantially spherical granules, wherein each granule comprises an agglomeration of particulate source metal in the binder. The granules are debinded at a debinding temperature to remove the binder from the granules forming debinded granules. The debinded granules are at least partially sintered at a sintering temperature such that particles within each granule fuse together to form partially or fully sintered solid granules. The granules can then be optionally recovered to form a substantially spherical metal powder. | 03-17-2016 |
20160074556 | SIMPLE COACERVATES AND METHODS OF USE THEREOF - Described herein is the synthesis of adhesive from simple adhesive coacervates and their uses thereof. The adhesives are produced by (a) preparing a solution comprising (1) a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, the polyeletrolyte comprises at least one crosslinking group, and (2) a sufficient amount of a complimentary counterion to produce a simple adhesive coacervate; and (b) crosslinking the simple adhesive coacervate to produce the adhesive. The adhesives have numerous medical and non-medical applications. | 03-17-2016 |
20160059202 | METHODS OF MAKING AND USING MICROARRAYS SUITABLE FOR HIGH-THROUGHPUT DETECTION - Disclosed are high density microarrays and methods for making and using such microarrays. The microarrays of the present invention can have uniformly shaped and sized sensing zones and are designed to allow high-throughput detection assays with minimal noise. | 03-03-2016 |
20160040169 | MORPHOLINOS, MORPHOLINO UPREGULATING, AND ASSOCIATED METHODS - Various methods and compositions relating to vascular endothelial growth factor receptor 2 (VEGFR2) are provided. In one aspect, a method of increasing expression of the soluble form of VEGFR2 (sVEGFR2) in a subject can include binding an antisense morphoiino to an exon13-intron13 splicing site of VEGFR2 mRNA such that the VEGFR2 niRNA is spliced into a sVEGFR2 isoform, | 02-11-2016 |
20150322120 | SODIUM CHANNEL SENSITIVE CONOPEPTIDES AND ANALOGS, INCLUDING COMPOSITIONS AND METHODS THEREOF - The present invention relates to conopeptides that are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which block the sodium channels. | 11-12-2015 |
20150290224 | ACTIVATED NITRIC OXIDE DONORS AND METHODS OF MAKING AND USING THEREOF - Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) an O | 10-15-2015 |
20150289751 | Polymeric Articles Having a Nanoscopically and/or Microscopically Rough Surface, Methods of Use thereof, and Methods for Fabrication Thereof - Polymeric articles that include a nanoscopically and/or microscopically rough surface formed on at least a portion of the article. Methods of using and making such articles are also disclosed. In one embodiment, covers for use with a surgical viewing instrument that include the nanoscopically and/or microscopically rough surface are disclosed. The cover includes a cover configured for placement over at least a portion of a surgical viewing instrument, at least a portion of the cover being transparent to light, and a nanoscopically and/or microscopically rough surface formed on at least a portion of the cover. The nanoscopically and/or microscopically rough surface is configured to shed and/or incorporate into a thin, substantially uniform film such droplets, fogs, and debris for providing clearer and less obstructed vision at a surgical, diagnostic or procedure site. | 10-15-2015 |
20150225466 | COMPOSITIONS AND METHODS FOR PEPTIDE EXPRESSION AND PURIFICATION USING A TYPE III SECRETION SYSTEM - Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided. | 08-13-2015 |
20150204836 | SOLUBLE METAL SENSOR COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME - Described herein are the preparation and use of metal sensor compounds in detecting metals that are toxic to humans or to the environment. In one aspect, the metal sensor compounds comprise a polycyclic aryl group (PAC), wherein at least one solubilizing group and at least one metal binding ligand are covalently bonded to (PAC). | 07-23-2015 |
20150182601 | COMPOSITIONS AND METHODS FOR SELECTIVELY PRODUCING SIRNA - The disclosure provided herein provides compositions and methods for producing siRNA. Also disclosed are compositions and methods for modulating the production of siRNA. Also disclosed herein are compositions and methods of treating a disease in a subject comprising administering a Dicer enzyme comprising a helicase domain or a mutated Dicer enzyme to a subject. Also disclosed herein are methods of screening for a candidate modulator that modulates siRNA production. | 07-02-2015 |
20150150864 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS - In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 06-04-2015 |
20150148869 | CHARGE STEERING HIGH DENSITY ELECTRODE ARRAY - Technology for deep brain stimulating including devices, systems, computer circuitry, and associated methods is provided. A deep brain stimulating device ( | 05-28-2015 |
20150145986 | ANNULAR THERMOACOUSTIC ENERGY CONVERTER - A thermoacoustic energy converter for converting heat energy to electricity includes an annular resonator with a regenerator disposed therein. An electro-mechanical transducer is coupled to the annular resonator and in fluid communication with the working fluid. When heat is applied to one end of the annular resonator, a traveling acoustic wave is generated in the annular resonator causing vibrations in the working fluid that actuate the electro-mechanical transducer to generate electricity. | 05-28-2015 |
20150119332 | ISOFORM-SELECTIVE INHIBITORS AND ACTIVATORS OF PDE3 CYCLIC NUCLEOTIDE PHOSPHODIESTERASES - The present invention concerns methods and compositions related to type 3 phosphodiesterases (PDE3). Certain embodiments concern isolated peptides corresponding to various PDE3A isoforms and/or site-specific mutants of PDE3A isoforms, along with expression vectors encoding such isoforms or mutants. In specific embodiments, methods for identifying isoform-selective inhibitors or activators of PDE3 are provided, along with methods of use of such inhibitors or activators in the treatment of dilated cardiomyopathy, pulmonary hypertension and/or other medical conditions related to PDE3 effects on cAMP levels in different intracellular compartments. In particular, techniques are disclosed herein relating to the identification of a test compound that binds to an isolated polypeptide such as PDE3A2 and assaying the test compound for its ability to exhibit superior ability to interfere with binding of the isolated polypeptide when compared with at least a second isolated polypeptide such as of PDE3A1 and methods of treatment of cardiomyopathy, pulmonary hypertension involving the resulting test compound. | 04-30-2015 |
20150118760 | FLUORESCENT SENSING OF VAPORS USING TUBULAR NANOFIBRIL MATERIALS - A fluorescence-based sensor can comprise a nanofiber mass of nanofibers having tubular morphology and a fluorescence detector, where fluorescence of the nanofibers decreases upon contact with a nitro-containing compound. The nanofibers can comprise carbazole-cornered, arylene-ethynylene tetracyclic macromolecules of formula I: where R1-R4 are alkyl-containing groups. The tubular morphology allows for highly selective detection of trinitrotoluene over other nitro-based compounds and oxidizing organic compounds. | 04-30-2015 |
20150118758 | COMPOUNDS, SENSORS, METHODS, AND SYSTEMS FOR DETECTING GAMMA RADIATION - Methods, compositions, and systems for detecting gamma radiation is disclosed and described. A compound for detecting gamma radiation can comprise a conjugated imidazole having the following structure: [Formula I] where at least one of R1, R2, and R3 are conjugated organic groups. Additionally, the conjugated imidazole can be capable of reacting with a radical or ion formed by the reaction of gamma radiation with a radical generating component such as a halogen solvent to decrease a molar extinction coefficient of the conjugated imidazole in the visible light region or to quench fluorescence of the conjugated imidazole. As a sensor (100), a radiation detection indicator (108) can indicate the change in molar extinction coefficient or fluorescence of the conjugated imidazole material (120) upon exposure to gamma radiation. | 04-30-2015 |
20150118715 | EXTREME PCR - Methods, devices, and kits are provided for performing PCR in <20 seconds cycle, with improved efficiency and yield. | 04-30-2015 |
20150072352 | SMALL MOLECULE-DEPENDENT SPLIT APTAMER LIGATION - Methods, assays, and products for the detection of small molecules are provided. In one aspect, for example, a method of detecting a small molecule in a sample can include reacting together a first half of a DNA split aptamer having a first reactive group coupled thereto, a second half of a DNA split aptamer having a second reactive group coupled thereto, where the DNA split aptamer is selective for the small molecule, and a sample containing the small molecule. The first half and the second half bind to the small molecule and the first reactive group and the second reactive group react to form an aptamer ligation product of the first half and the second half. The method can also include assaying for the aptamer ligation product in order to detect the small molecule presence in the sample. | 03-12-2015 |
20150063532 | MULTILEVEL COMPUTED TOMOGRAPHY FOR RADIALLY-SHIFTED FOCAL SPOTS - In one example embodiment, a method of volumetric image reconstruction of an examination region includes directing x-rays from an anode of an x-ray device towards the examination region from multiple positions relative to the examination region, including multiple focal spot positions radially shifted relative to the anode. X-rays that have passed through the examination region are detected and first multiple x-ray attenuation values are determined for each of the multiple positions. The first multiple x-ray values are based at least in part on the detected x-rays. Second multiple x-ray attenuation values associated with multiple levels are determined. The second multiple attenuation values are based at least in part on the first multiple attenuation values and the multiple positions. The method further includes generating a volumetric image reconstruction of the examination region based at least in part on the second multiple x-ray attenuation values. | 03-05-2015 |
20150038705 | METHODS OF USE COMPRISING A BIOCIDAL POLYAMINE - Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms. | 02-05-2015 |
20150025114 | SUBSTITUTED 1H-INDAZOL-1-OL ANALOGS AS INHIBITORS OF BETA CATENIN/TCF PROTEIN-PROTEIN INTERACTIONS - In one aspect, the invention relates to substituted 1H-benzo[d][1,2,3]triazol-1-ol analgoues, derivatives thereof, and related compound; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g. various tumors and cancers, associated with β-catenin/Tcf protein-protein interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 01-22-2015 |
20150024998 | ISOLATION, IDENTIFICATION, AND USES OF ANTIFUNGAL COMPOUNDS - In one aspect, the invention relates to isolated compounds useful as antifungal agents, for example, compounds having a structure represented by a formula: wherein R | 01-22-2015 |
20150018349 | SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS - In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 01-15-2015 |
20150011867 | Retrospectively Correlated Turbo Spin Echo Imaging - Systems and methods which generate a sequence of images using turbo spin echo magnetic resonance imaging which are retrospectively correlated with periodic motion occurring within a subject being imaged are described. In one embodiment, k-space measurements (or the measurements from which images are formed) are captured during, and correlated with, different phases in a cardiac cycle of the subject. With this sequence, the images that are produced are able to show, and/or compensate for, motion correlated with the cardiac cycle of the subject. | 01-08-2015 |
20140377380 | METHODS AND COMPOSITIONS FOR TREATING NEPHROGENIC DIABETES INSIPIDUS - Disclosed is a treatment of diabetes insipidus. Methods of treating diabetes insipidus disorders associated with P2Y receptors using the compounds and compositions are also disclosed. | 12-25-2014 |
20140358116 | METHODS FOR DELIVERING AN ANTI-CANCER AGENT TO A TUMOR - Described herein are methods for delivering an anti-cancer agent to a tumor in a subject. The method involves
| 12-04-2014 |
20140357732 | METHODS OF PREDICTING THE DEVELOPMENT OF COMPLEMENT-MEDIATED DISEASE - Described herein are methods for determining a Caucasian subject's susceptibility to having or developing a complement-mediated disease comprising determining in the Caucasian subject the identity of one or more haplotypes, wherein the presence of one or more of the haplotypes indicates the subject's susceptibility for having or developing a complement-mediated disease. | 12-04-2014 |
20140350047 | ISOFORM-SELECTIVE INHIBITORS AND ACTIVATORS OF PDE3 CYCLIC NUCLEOTIDE PHOSPHODIESTERASES - The present invention concerns methods and compositions related to type 3 phosphodiesterases (PDE3). Certain embodiments concern isolated peptides corresponding to various PDE3A isoforms and/or site-specific mutants of PDE3A isoforms, along with expression vectors encoding such isoforms or mutants. In specific embodiments, methods for identifying isoform-selective inhibitors or activators of PDE3 are provided, along with methods of use of such inhibitors or activators in the treatment of dilated cardiomyopathy, pulmonary hypertension and/or other medical conditions related to PDE3 effects on cAMP levels in different intracellular compartments. | 11-27-2014 |
20140346948 | MICRO-PLASMA FIELD EFFECT TRANSISTORS - In some aspects, a micro-plasma device comprises a plasma gas enclosure containing at least one plasma gas, a plasma generation circuit interfaced with the plasma gas enclosure, and a plurality of electrodes interfaced with the plasma gas enclosure. In other aspects, a micro-plasma circuitry apparatus comprises a first layer having plasma generating electrodes, a second layer having a cavity formed therein, and a third layer having a circuit formed therein. The circuit includes a micro-plasma circuit (MPC) that includes one or more micro-plasma devices (MPDs). A metallic layer covers the MPC except at locations of the MPDs. The first layer is bonded to the second layer and the second layer is bonded to the third layer, thereby forming an enclosure that contains at least one plasma gas. | 11-27-2014 |
20140343011 | METHODS FOR TREATING OR PREVENTING UROLOGICAL INFLAMMATION - Described herein are methods for treating or preventing urological inflammation in a subject comprising administering to the subject an effective amount of a compound comprising a. a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and at least one primary C-6 hydroxyl position of an N-acetyl-glucosamine residue comprising an alkyl group or fluoroalkyl group; b. a partially or fully sulfated hyaluronan or the pharmaceutically acceptable salt or ester thereof, or a combination thereof. | 11-20-2014 |
20140342926 | Methods for Assessing Risk for Cardiac Dysrythmia in a Human Subject - The present invention relates to methods for assessing the risk of a patient for developing a potentially fatal cardiac dysrhythmia and for diagnosing Andersen's Syndrome. A tissue sample from a patient is obtained and the DNA or proteins of the sample isolated. From the DNA and protein isolates the sequence of the KCNJ2 gene or the Kir2.1 polypeptide can be obtained. The KCNJ2 gene or the Kir2.1 can be screened for alteration as compared to the wile-type sequence. An alteration in a copy of the KCNJ2 gene or a Kir2.1 polypeptide indicates that the patient has a high risk for developing a cardiac dysrhythmia and can be diagnosed with Andersen's Syndrome. The invention also related to isolated nucleic acid molecules with one or more alterations as compared to the wild-type sequence. | 11-20-2014 |
20140341803 | STABLE NANOEMULSIONS USEFUL IN THE TREATMENT OF CANCER - Described herein are methods for treating a tumor or cancer in a subject. The methods involve administering to the subject a nanoemulsion comprising (1) at least one perfluoro crown ether and (2) a block copolymer comprising a hydrophilic block and hydrophobic block, wherein the hydrophobic block is poly(d,l)lactic acid, and wherein the nanoemulsion comprises a therapeutic agent encapsulated in the nanoemulsion. The methods do not require the application of ultrasound or other sources of radiation in order to treat a tumor or cancer in the subject. | 11-20-2014 |
20140323413 | METHODS OF DIAGNOSING AND TREATING VASCULAR ASSOCIATED MACULOPATHY AND SYMPTOMS THEREOF - Disclosed herein are methods and compositions for the diagnosis and treatment of Vascular Associated Maculopathy, or a symptom thereof, in a subject. Disclosed herein are methods and compositions for the diagnosis and treatment of one or more symptoms associated with Vascular Associated Maculopathy Disclosed in a subject. Disclosed herein are methods and compositions for the diagnosis and treatment of severe maculopathy or last stage maculopathy in a subject. Disclosed herein are methods and compositions for the diagnosis and treatment of resolving aberrant choriocapillaris lobules in a subject. | 10-30-2014 |
20140323392 | METHODS AND COMPOSITIONS RELATED TO INHIBITION OF VIRAL ENTRY - Disclosed herein are compositions and methods for inhibiting viral entry. | 10-30-2014 |
20140303013 | METHODS OF DIAGNOSING AND TREATING VASCULAR ASSOCIATED MACULOPATHY AND SYMPTOMS THEREOF - Disclosed herein are methods and compositions for the diagnosis and treatment of Vascular Associated Maculopathy, or a symptom thereof, in a subject. Disclosed herein are methods and compositions for the diagnosis and treatment of one or more symptoms associated with Vascular Associated Maculopathy Disclosed in a subject. Disclosed herein are methods and compositions for the diagnosis and treatment of severe maculopathy or last stage maculopathy in a subject. Disclosed herein are methods and compositions for the diagnosis and treatment of resolving aberrant choriocapillaris lobules in a subject. | 10-09-2014 |
20140288100 | GALACTOKINASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF ASSOCIATED DISEASES AND DISORDERS - Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal. Formula (I) | 09-25-2014 |
20140287147 | PHOTONIC DEVICES ON PLANAR AND CURVED SUBSTRATES AND METHODS FOR FABRICATION THEREOF - A versatile and rapid sol-gel technique for the fabrication of high quality one-dimensional photonic bandgap materials. For example, silica/titania multi-layer materials may be fabricated by a sol-gel chemistry route combined with dip-coating onto planar or curved substrate. A shock-cooling step immediately following the thin film heat-treatment process is introduced. This step was found important in the prevention of film crack formation—especially in silica/titania alternating stack materials with a high number of layers. The versatility of this sol-gel method is demonstrated by the fabrication of various Bragg stack-type materials with fine-tuned optical properties by tailoring the number and sequence of alternating layers, the film thickness and the effective refractive index of the deposited thin films. Measured optical properties show good agreement with theoretical simulations confirming the high quality of these sol-gel fabricated optical materials. | 09-25-2014 |
20140278305 | Fast Iterative Method for Processing Hamilton-Jacobi Equations - A system and method are provided for a parallel processing of the Hamilton-Jacobi equation. A numerical method is provided to solve the Hamilton-Jacobi equation that can be used with various parallel architectures and an improved Godunov Hamiltonian computation. | 09-18-2014 |
20140275972 | HIGH TEMPORAL RESOLUTION MONITORING OF CONTACT BETWEEN CATHETER TIP AND TARGET TISSUE DURING A REAL-TIME-MRI-GUIDED ABLATION - A method of monitoring a position of a catheter tip relative to a target tissue. The method includes steps of identifying a wall structure in the target tissue; guiding a catheter towards the wall structure; monitoring a location of the catheter; directing a navigator beam towards the wall structure; aligning the navigator beam with the location of the catheter; monitoring a position of the wall structure using the navigator beam; and determining the position of the wall structure relative to the location of the catheter. | 09-18-2014 |
20140256815 | USE OF NITRATED LIPIDS FOR TREATMENT OF SIDE EFFECTS OF TOXIC MEDICAL THERAPIES - The present invention relates to methods of treating the side effects of a toxic medical therapy using nitrated lipids. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents. | 09-11-2014 |
20140249762 | GENOMIC TENSOR ANALYSIS FOR MEDICAL ASSESSMENT AND PREDICTION - Systems and methods are described for medical characterization of biological data. One such method includes applying a decomposition algorithm, by a processor, to an Nth-order tensor representing data, wherein N≧2, to generate, from at least two submatrices A and B of the tensor, eigenvectors of each of AA | 09-04-2014 |
20140235510 | MICROFLUIDIC INTERFACE FOR HIGHLY PARALLEL ADDRESSING OF SENSING ARRAYS - Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on, a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time. | 08-21-2014 |
20140235472 | METHODS AND COMPOSITIONS FOR THE DETECTION OF BALANCED RECIPROCAL TRANSLOCATIONS/REARRANGEMENTS - Disclosed are methods and compositions related to the detection of balanced reciprocal translocations/rearrangements and determination of the location of said balanced reciprocal translocations/rearrangements. Also disclosed are methods and compositions relating to the diagnosis of a disease or condition associated with uncontrolled cellular proliferation by the detection of balanced reciprocal translocation/rearrangement. Additionally, also disclosed are kits for the detection of balanced reciprocal translocations/rearrangements. | 08-21-2014 |
20140220152 | Compositions and Methods for Detecting, Treating, or Preventing Reductive Stress - Disclosed herein is a non-human animal model of protein aggregation cardiomyopathy. Also disclosed are compositions and methods of treating or preventing a condition in a subject caused or exacerbated by reductive stress. Also disclosed are compositions and methods of predicting, detecting, or monitoring reductive stress in a subject. | 08-07-2014 |
20140220082 | ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF - Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are produced by reacting (a) at least one poly anion comprising a plurality of activated ester groups, and (b) at least one polycation comprising a plurality of nucleophilic groups, wherein the nucleophilic groups react with the activated ester groups to produce a new oovalent bond between the polycation and the polyanion. The adhesive complex coacervates described herein have low interfacial tension with water and wettable substrates. When applied to a wet substrate they spread over the interface rather than beading up. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in wet or underwater applications and situations where water is present such as, for example, physiological conditions. | 08-07-2014 |
20140212392 | METHOD OF ISOLATING HUMAN NEUROEPITHELIAL PRECURSOR CELLS FROM HUMAN FETAL TISSUE - A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided. | 07-31-2014 |
20140212357 | CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS - Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. | 07-31-2014 |
20140195002 | PERCUTANEOUS OSSEOINTEGRATED IMPLANT ASSEMBLY FOR USE IN SUPPORTING AN EXO-PROSTHESIS - An implant assembly for a long bone is adapted to support an exo-prosthesis. The assembly includes a stem, a subdermal component and a percutaneous post. The stem has a proximal end that is adapted to be received in a surgically prepared medullary canal of the long bone, and a distal end having a surface that is adapted to promote bone ingrowth. The subdermal component includes a proximal portion that is adapted for attachment to the distal end of the stem, and a fixation surface that is adapted to promote soft tissue fixation. The percutaneous post has a proximal end that is adapted to be attached to the subdermal component. | 07-10-2014 |
20140170752 | GENERATION OF iPS CELLS AND ASSOCIATED METHODS - Systems, constructs, and methods for reprogramming cells are provided. In one aspect, for example, a transformation construct for generating iPS cells can include an expression vector having a plurality of reprogramming factors, each reprogramming factor being under control of a separate promoter. | 06-19-2014 |
20140165219 | MUTANT SODIUM CHANNEL Nav1.7 AND METHODS RELATED THERETO - Described are mutant Na | 06-12-2014 |
20140161906 | USE OF ANGIOGENESIS ANTAGONISTS IN CONDITIONS OF ABNORMAL VENOUS PROLIFERATION - The present application describes therapy with angiogenesis antagonists such as anti-VEGF antibodies. In particular, the application describes the use of such angiogenesis antagonists to treat end-stage liver disease and end-stage liver disease complications. The present application also describes the use of such angiogenesis antagonists to treat disorders of altered venous proliferation such hemorrhoids and varicose veins. | 06-12-2014 |
20140160569 | Apparatus and Methods for Reducing Frequency or Severity of Photophobic Responses or Modulating Circadian Cycles - The present disclosure describes systems, methods, and apparatus for reducing the frequency and/or severity of photophobic responses or for modulating circadian cycles by controlling light exposure to melanopsin ganglion cells in a retina over the action potential spectrum of the melanopsin cells of the human eye and a visual spectral response of the human eye. Embodiments of an optical filter are described. In one embodiment an optical filter may be configured to transmit less than a first amount of light weighted across the action potential spectrum of the melanopsin cells and to transmit more than a second amount of light weighted across the visual spectral response. Methods of manufacturing optical filters are also described. | 06-12-2014 |
20140156022 | Percutaneous Osseointegrated Prosthetic Implant System - An implant system for securing a prosthesis to a selected bone of a subject including a stem and an abutment. The stem includes a porous region that promotes osseointegration of the selected bone following implantation of the stem. The abutment is secured to the stem and is configured for secure attachment to the prosthesis. The stem and the abutment include ultra-low friction and/or highly polished surfaces at select locations that inhibit bio-adhesion. | 06-05-2014 |
20140135570 | METHODS, SYSTEMS, AND APPARATUS FOR REDUCING THE FREQUENCY AND/OR SEVERITY OF PHOTOPHOBIC RESPONSES OR FOR MODULATING CIRCADIAN CYCLES - The present disclosure describes systems, methods, and apparatus for reducing the frequency and/or severity of photophobic responses or for modulating circadian cycles by controlling light exposure to cells in the human eye in certain wavelengths, such as 480 nm and 620 nm, and a visual spectral response of the human eye. Embodiments of an optical filter are described. In one embodiment an optical filter may be configured to transmit less than a first amount of light in certain wavelengths, and to transmit more than a second amount of light weighted across the visual spectral response. Methods of use and methods of manufacturing optical filters are also described. | 05-15-2014 |
20140126801 | Microscopy Visualization - A method is described for correlating microscopy images from a number of modalities in a sub diffraction resolution environment. The method may include receiving a number of datasets that may represent microscopy captures from a number of different modalities. The microscopy captures may contain feature markers that may be used to register a number of data points contained in a dataset with data points from another dataset. Upon registering the data points of the datasets, a combined dataset may be produced and a visual image of the combined dataset may be provided. | 05-08-2014 |
20140120079 | Compositions and Methods for Diagnosing and Treating Diabetic Micro Vascular Complications - Disclosed herein are compositions and methods for the identification of a subject at risk for developing microvascular complications associated with diabetes such as diabetic nephropathy and diabetic retinopathy. Also disclosed is a therapeutic target for the prevention and treatment of microvascular complications associated with diabetes. | 05-01-2014 |
20140114164 | SYSTEM AND METHOD FOR ELECTRICALLY SHIELDING A MICROELECTRODE ARRAY IN A PHYSIOLOGICAL PATHWAY FROM ELECTRICAL NOISE - A system and method for electrically shielding a physiological pathway from electrical noise is disclosed. The method includes the operation of implanting at least one signal microelectrode into a patient such that the signal microelectrode is proximate to the physiological pathway. An additional operation includes substantially enclosing the microelectrode and a section of the physiological pathway with an electrical shielding wrap. The electrical shielding wrap includes a plurality of holes that enable fluid communication of physiological fluids between an inside and outside of the wrap. | 04-24-2014 |
20140107152 | SENSORY RECEPTORS FOR CHRONIC FATIGUE AND PAIN AND USES - The present invention relates generally to the fields of pathological muscle pain/fatigue conditions. More specifically, the invention concerns methods and compositions useful for diagnosing and treating pathological muscle pain/fatigue conditions. | 04-17-2014 |
20140104273 | INTERACTIVE EXTRACTION OF NEURAL STRUCTURES WITH USER-GUIDED MORPHOLOGICAL DIFFUSION - A method of identifying a structure in a volume of data. The method includes steps of generating a scalar mask volume which corresponds to at least a portion of the volume of data; displaying the volume of data to a user through a viewport; obtaining from a user at least one seed region identified on the viewport; projecting the seed region from the viewport into the scalar mask volume to identify at least one segmentation seed within the scalar mask volume; obtaining from a user at least one diffusion region identified on the viewport; projecting the diffusion region from the viewport into the scalar mask volume to identify a region for seed growth within the scalar mask volume; and growing the at least one segmentation seed within the scalar mask volume to identify a structure within the volume of data. | 04-17-2014 |
20140094445 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS - In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 04-03-2014 |
20140089004 | PATIENT COHORT LABORATORY RESULT PREDICTION - A computer-based tool and associated methods use biological sequence analysis techniques to predict clinical outcomes, such as diagnostic test results, for a patient based on outcome behaviors in cohorts of similar patients. | 03-27-2014 |
20140089003 | PATIENT HEALTH RECORD SIMILARITY MEASURE - Computer-implemented methods for determining optimal treatments for a patient can include identifying successful treatments used in cohorts of persons considered similar to the patient. Tools implementing such methods can use biological sequence analysis techniques to identify practices best suited for the patient. | 03-27-2014 |
20140086886 | Stem Cell, Precursor Cell, or Target Cell-Based Treatment of Multi-Organ Failure and Renal Dysfunction - Methods for the treatment of acute renal failure, multi-organ failure, early dysfunction of kidney transplant, chronic renal failure, organ dysfunction, and wound healing are provided. The methods include delivering a therapeutic amount of hematopoietic stem cells, non-hematopoietic, mesenchymal stem cells, hemangioblasts, and pre-differentiated cells to a patient in need thereof. | 03-27-2014 |
20140066950 | SPINAL CORD STIMULATION SYSTEM - A method for optimizing the stimulation of the dorsal column of the spinal cord is disclosed. The method includes providing a stimulating electrode array and a frame element. The frame element is configured to couple to the stimulating electrode array and guide the stimulating electrode array to a desired position proximate the dorsal column of the spinal cord of a subject. | 03-06-2014 |
20140053250 | Access to Web Application via a Mobile Computing Device - Technology is described for allowing access to a web application using a mobile computing device. The method can include obtaining a secure user identifier associated with the mobile computing device as confirmed by a secure wireless network. A hardware device identifier can be retrieved from the mobile computing device. Physical location coordinates can be identified for the mobile computing device. The user identification, hardware device identifier and the physical location can be sent to a web server. Another operation can be enabling access to the web application based on the secure user identifier, a hardware device identifier and correct physical location coordinates as defined by the web application. | 02-20-2014 |
20140039253 | Optically Guided Feeding Tube, Catheters and Associated Methods - The present invention provides devices and methods for safe, easy and cost effective means of placing and verifying proper placement of nasogastric and nasoenteric feeding tubes. Specifically, an integrated feeding device including a tube operable to deliver a nutritional and/or medicinal substance to the gastrointestinal tract, an optical system including a light source, flexible optical fibers or a camera, and a lens, and a steering system is disclosed. The components of the system, namely the optical system and the steering system, may be integrated into the tube. | 02-06-2014 |
20140027710 | QUANTUM DOT AND NANOWIRE SYNTHESIS - A self-assembled semiconductor nanostructure includes a core and a shell, wherein one of the core or the shell is rich in a strained component and the other of the core or the shell is rich in an unstrained component, wherein the nanostructure is a quantum dot or a nanowire. A method includes growing a semiconductor alloy structure on a substrate using a growth mode that produces a semiconductor alloy structure having a self-assembled core and shell and allowing the structure to equilibrate such that one of the core or the shell is strained and the other is unstrained. Another method includes growing at least one semiconductor alloy nanostructures on a substrate, wherein the nanostructure comprises a strained component and an unstrained component, and controlling a compositional profile during said growing such that a transition between the strained component and an unstrained component is substantially continuous. | 01-30-2014 |
20140024713 | USE OF NITRATED LIPIDS FOR TREATMENT OF SIDE EFFECTS OF TOXIC MEDICAL THERAPIES - Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents. | 01-23-2014 |
20140018400 | METHODS AND COMPOSITIONS RELATED TO NEUROACTIVE THIAZOLINE COMPOUNDS - In one aspect, the invention relates to compounds having a general structure: and methods of using same to modulate calcium release. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 01-16-2014 |
20140012106 | STRETCHABLE CIRCUIT CONFIGURATION - A stretchable electronic circuit that includes a stretchable base substrate having a plurality of stretchable conductors formed onto a surface thereof, with both the stretchable base substrate and conductors being bendable together about two orthogonal axes. The stretchable circuit also includes a stretchable sensor layer attached to the base substrate with a cavity formed therein which has a contact point exposing one of the plurality of stretchable conductors. The stretchable electronic circuit further includes a surface mount device (SMD) package with a conductor contact protrusion installed into the cavity, and wherein a substantially constant electrical connection is established between the conductor contact protrusion and the stretchable conductor at the contact point by tensile forces interacting between the stretchable base substrate and the stretchable sensor layer. | 01-09-2014 |
20140011193 | APTAMER-BASED LATERAL FLOW ASSAY AND ASSOCIATED METHODS - Methods, assays, and products for the detection of analytes in a sample are provided. In one aspect, for example, a device for detecting an analyte in a sample can include a fluid transfer membrane further including a sample input region operable to receive a liquid sample, a reagent region including a first split aptamer segment, a second split aptamer segment, and a detection marker, where the first and second split aptamers are operable to ligate in the presence of the analyte. The detection marker is operable to bind to the second split aptamer. The device can further include a test region having an immobilized binding reagent operable to bind to the first split aptamer segment such that the detection marker is held in the test region when the first split aptamer segment is ligated to the second split aptamer segment due to the analyte being present in the sample. | 01-09-2014 |
20130343518 | DYNAMIC COLLIMATION FOR COMPUTED TOMOGRAPHY - A collimator for a computed tomography imaging device can include first and second leaves positioned on and bounding opposing sides of a radiation delivery window. The first and second leaves can be movable to adjust at least one of a size or a location of the primary radiation delivery window relative a the radiation source in a direction non-parallel to an axis of rotation of the radiation source. | 12-26-2013 |
20130343514 | DYNAMIC POWER CONTROL OF COMPUTED TOMOGRAPHY RADIATION SOURCE - A method of contrast-enhanced computed tomography (CT) imaging can include repeatedly scanning a target region an applied power during a session. The applied power can be a first power for a first scan. After the first scan, the applied power for each of a plurality of scans can be selected based on an algorithm. The algorithm can be based on, for example, the attenuation indicated from a preceding scan in the session. | 12-26-2013 |
20130343513 | GRATED COLLIMATION SYSTEM FOR COMPUTED TOMOGRAPHY - A collimator for a computed tomography imaging device can include first and second leaves positioned on opposing sides of a primary radiation delivery window. The first and second leaves can include first and second gratings having a plurality of attenuating members with a plurality of secondary radiation delivery windows extending between adjacent attenuating members. | 12-26-2013 |
20130343512 | ADAPTIVE CONTROL OF SAMPLING FREQUENCY FOR COMPUTED TOMOGRAPHY - A method of contrast-enhanced computed tomography (CT) imaging can include repeatedly scanning a target region at a frequency during a session, the frequency initially being a first rate. After detecting an increase of the attenuation of radiation by a contrast-enhanced first structure within a target region, the frequency can be increased to a second rate. After detecting a subsequent decrease in the attenuation, the frequency can be decreased to a third rate. | 12-26-2013 |
20130324609 | DEPRESSION DISORDER THERAPEUTICS WITH CREATINE ANALOGS - In one aspect, the invention relates to creatine analogs, compositions comprising same, and methods of using same, alone or in combination with other agents, to treat depression disorders and associated maladies. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-05-2013 |
20130320804 | ANNULAR THERMOACOUSTIC ENERGY CONVERTER - A thermoacoustic energy converter for converting heat energy to electricity includes an annular resonator with a regenerator disposed therein. An electro-mechanical transducer is coupled to the annular resonator and in fluid communication with the working fluid. When heat is applied to one end of the annular resonator, a traveling acoustic wave is generated in the annular resonator causing vibrations in the working fluid that actuate the electro-mechanical transducer to generate electricity. | 12-05-2013 |
20130312966 | IN SITU DECOMPOSITION OF CARBONYLS AT HIGH TEMPERATURE FOR FIXING INCOMPLETE AND FAILED WELL SEALS - Methods and systems relating to in situ decomposition of carbonyls at high temperature for fixing incomplete and failed well seals, are described. According to one embodiment, a method, comprises injecting a sealing agent into a subterranean well having sealing channels or voids in well casings. An alkaline-earth carbonate precipitate is formed from the decomposition of a carbonyl compound. The sealing agent includes the carbonyl compound and an alkaline-earth halide salt. | 11-28-2013 |
20130281410 | METHODS FOR THE TREATMENT OF PSYCHIATRIC DISORDERS - The invention provides methods for the treatment of major depressive disorder in male subjects and methods for the treatment of psychiatric disorders at high altitudes by administering one or more creatine-containing compounds. | 10-24-2013 |
20130269441 | ULTRASONIC METHOD AND SYSTEM FOR DETERMINING TISSUE PATHOLOGY - A method for determining a pathology of a tissue sample. The method includes steps of coupling the tissue sample between two oppositely-facing ultrasonic transducers; acquiring a pulse-echo ultrasonic measurement and a through-transmission ultrasonic measurement of the tissue sample using the ultrasonic transducers; analyzing at least one of the pulse-echo ultrasonic measurement and the through-transducer transmission ultrasonic measurement using time domain analysis; analyzing at least one of the through-transmission ultrasonic measurements and the pulse-echo ultrasonic measurements using frequency domain analysis; and determining the pathology of the tissue sample based on at least one of the time domain analysis and the frequency domain analysis. | 10-17-2013 |
20130267955 | SYSTEMS FOR CONTROLLING BONE GROWTH - Systems and methods for stabilizing portions of bone are provided. In some aspects, a bone fixation system can include a plate configured to be fastened to a growing bone to control growth of the bone in at least one direction. The system can include a keel structure having a longitudinal axis. The keel can extend from the plate into the bone to permit bone growth along the keel longitudinal axis on one side of the bone while the plate generally inhibits growth on the other side of the bone. | 10-10-2013 |
20130267362 | Bicycle Transmission - Embodiments are directed to bicycle drive trains, as well as methods and systems for changing gear ratios within the bicycle drive trains. A bicycle drive train includes a crank assembly, where the crank assembly is configured to rotate about an axis. The crank assembly defines a plane generally transverse to the axis. The crank assembly includes at least one driving gear in the plane that is of a first gear size. The crank assembly is also configured to selectively vary the size of the driving gear in the plane, so that the driving gear changes size while remaining positioned within the plane. The crank assembly may also be configured to include hinged gear segments that, when moved about their hinge, allow gear shifts along the same linear plane. | 10-10-2013 |
20130253664 | ANTIMICROBIAL CONTAINMENT CAP FOR A BONE ANCHORED PROSTHESIS MOUNTING - An antimicrobial containment cap is provided for use in a bone anchored prosthesis mounting system of the type having an externally protruding fixator pin carried by implanted bone anchored mounting post, wherein the fixator pin accommodates removable attachment to an exoskeletal prosthesis such as a prosthetic limb or the like for an amputee. The containment cap, when mounted onto the fixator pin, is interposed between the prosthesis and soft tissue covering the end or stump of an amputated residual limb or the like. The containment cap carries and supports a selected antimicrobial or antibacterial agent in substantial contact with the soft stump tissue in a position closely overlying and substantially circumscribing the tissue interface with the externally protruding fixator pin to safeguard against infection. The containment cap is adapted for quick and easy periodic removal for cleaning and/or replenishment of the antimicrobial agent. | 09-26-2013 |
20130244947 | METHODS AND COMPOSITIONS RELATED TO IMPROVING PROPERTIES OF PHARMACOLOGICAL AGENTS TARGETING NERVOUS SYSTEM - Disclosed are compositions and methods related to improving pharmacological properties of bioactive compounds targeting nervous system. | 09-19-2013 |
20130236396 | NANOPARTICLES PRODUCED FROM RECOMBINANT POLYMERS AND METHODS OF MAKING AND USING THE SAME - Described herein are nanoparticles produced from recombinant polymers. The nanoparticles are substantially uniform in size, which provides numerous advantages with respect to the delivery of bioactive agents to a subject. Methods for making the nanoparticles are also described herein. In one aspect, the nanoparticles are produced by the method comprising: a. providing a solution comprising one or more recombinant polymer in a solvent; b. forming droplets comprising the one or more recombinant polymers and the solvent; c. removing the solvent to produce the nanoparticles; and d. separating the nanoparticles based on size to produce nanoparticles that are substantially uniform in size. Finally, pharmaceutical compositions composed of the nanoparticles and methods of using the same are also described. | 09-12-2013 |
20130209531 | APPLICATIONS OF PARTIALLY AND FULLY SULFATED HYALURONAN - Described herein is the use of partially and fully sulfated hyaluronan or the pharmaceutically acceptable salt or ester thereof for therapeutic and cosmetic applications as well as the treatment of a number of systemic, dermatological, periodontal, ophthalmic, and urological inflammatory diseases. | 08-15-2013 |
20130209522 | Drug Release from a Polymer-Controlled Local Antibiotic Delivery System Using a Degradable Bone Graft - In some embodiments, the invention provides an implant comprising a uniform mixture of degradable polymer, bone, and a drug. In some embodiments, the drug comprises an antibiotic. In some embodiments, diffusion of the drug from the implant at a therapeutic level is maintained for an amount of time longer than an amount of time that a pathogen is senescent. In some embodiments, diffusion of the drug from the implant at a therapeutic level is maintained for at least eight weeks, or at least ten weeks, or at least twelve weeks post-implantation. In some embodiments, the therapeutic level is maintained at an implantation site of the implant. | 08-15-2013 |
20130208497 | INFUSION LINE IDENTIFICATION LIGHTING SYSTEM - An IV line identification system enables ready identification of an IV line and its associated fluid source and output from other IV lines with their fluid sources and outputs. The IV line identification system includes lights that are coupled to a specific IV line. The lights can identify specific locations on the IV line, such as an entry end by an IV bag and an output end by a needle or port associated with a patient. The lights can also identify the portions of the IV line that enter and exit a pump. The lights can also be selectively turned on when a specific IV line needs to be identified, and turned off when the IV line does not need to be individually identified. The lights may be colored to distinguish between the lights associated with another IV line. | 08-15-2013 |
20130208273 | Ultra-High Efficiency Color Mixing and Color Separation - Methods and apparatus for combining or separating spectral components by means of a polychromat. A polychromat is employed to combine a plurality of beams, each derived from a separate source, into a single output beam, thereby providing for definition of one or more of the intensity, color, color uniformity, divergence angle, degree of collimation, polarization, focus, or beam waist of the output beam. The combination of sources and polychromat may serve as an enhanced-privacy display and to multiplex signals of multiple spectral components. In other embodiments of the invention, a polychromat serves to disperse spectral components for spectroscopic or de-multiplexing applications. | 08-15-2013 |
20130204364 | VISION CORRECTION SYSTEM - A vision correction system comprising an intraocular lens having a lens body and one or more haptics is provided. The lens body may be configured to be positioned posteriorly to an iris of an eye and may have a convex anterior surface, a concave posterior surface, and a circumferential edge having a rounded anterior portion and a rounded posterior portion. Haptics may extend at an anterior angle from the lens body and be configured to contact the ciliary sulcus of an eye. The haptics and/or hydrophobic forces between this lens body and a second intraocular lens may secure the lens body in the eye in a relatively fixed position and prevent rotation of the lens over time. | 08-08-2013 |
20130204275 | METHODS, DEVICES AND APPARATUS FOR PERFORMING A VASCULAR ANASTOMOSIS - Methods, devices, apparatus, assemblies, and kits for performing a vascular anastomosis are disclosed. A device for a vascular anastomosis includes tissue engaging portions that can move between at least two configurations. In some embodiments, the tissue engaging portions move without the aid of moving parts, while in other embodiments the tissue engaging portions extend from one or more movable wings. The tissue engaging portions may be separated by a first distance when in a pre-deployment configuration and by a second distance when in a deployed configuration. A method includes engaging a plurality of tissue engaging members of a coupling device against first end tissue. After selectively engaging the tissue engaging members and first end tissue, the first end tissue is stretched by at least moving the tissue engaging members. The stretched first end tissue is coupled to the second end tissue by mating the coupling device to a mating anastomosis device. | 08-08-2013 |
20130190388 | Methods and Compositions Related to DLK-1 and the P38 MAPK Pathway in Nerve Regeneration - Disclosed are compositions and methods for treating neurodegenerative disease. | 07-25-2013 |
20130190234 | THE USE OF ALKYLATED SEMI-SYNTHETIC GLYCOSAMINOGLYCOSAN ETHERS FOR THE TREATMENT OF DENTAL DISORDERS - Described herein are methods for treating a dental disorder in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary C-6 hydroxyl proton of at least one N-acetyl-glucosamine residue is substituted with a C | 07-25-2013 |
20130189313 | ADHESIVE COMPLEX COACERVATES AND METHOD OF MAKING AND USING THEREOF - Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. They have numerous biological applications as bioadhesives and drug delivery devices and are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions. | 07-25-2013 |
20130184609 | 3D FABRICATION OF NEEDLE TIP GEOMETRY AND KNIFE BLADE - The present invention provides a method for creating a beveled needle or a blade. The method employs a side wall surface of an angled post as a base to control beveled tip geometry. The invention provides needles, microneedle arrays, blades and microblade arrays with sufficient sharpness and toughness. | 07-18-2013 |
20130183770 | METHODS FOR ANALYSIS OF FREE AND AUTOANTIBODY-BOUND BIOMARKERS AND ASSOCIATED COMPOSITIONS, DEVICES, AND SYSTEMS - The present invention provides methods, compositions, and kits associated with analyzing, enriching, and/or isolating a biomarker or analyte in a biological sample. In one aspect, for example, a method for determining a concentration of a biomarker in a biological sample can include binding any unbound biomarker with an antibody specific for the biomarker to form antibody-bound biomarker, enriching the antibody-bound biomarker and any endogenous autoantibody-bound biomarker to form an enriched fraction, identifying the biomarker in the enriched fraction, and determining the concentration of the biomarker in the biological sample. In one aspect, the concentration of the biomarker is derived from initially unbound biomarker and autoantibody-bound biomarker in the biological sample. | 07-18-2013 |
20130183766 | OPTOELECTRICAL VAPOR SENSING - A chemical sensor can comprise a nanofiber mass of p-type nanofibers having a HOMO level greater than −5.0 eV. Additionally, the chemical sensor can comprise oxygen in contact with the p-type nanofibers. Further, the chemical sensor can comprise a pair of electrodes in electrical contact across the nanofiber mass, where the p-type nanofibers conduct an electric current that decreases upon contact with an amine compound. | 07-18-2013 |
20130177523 | GOLD PARTICLES AND METHODS OF MAKING AND USING THE SAME IN CANCER TREATMENT - Described herein are gold particles that can be used to reduce tumor proliferation and treat cancer. In certain aspects, the gold particles can be modified in order to enhance selectivity and uptake of the particles by cancer cells. In certain aspects, the modified gold particles have a targeting group attached to the particle via a linker. The gold particles described herein can be used in combination with other anti-cancer agents in order to enhance overall cancer treatment. Methods for making and using the gold particles are also described herein. | 07-11-2013 |
20130172985 | CROSSLINKED HYDROGELS AND METHODS OF MAKING AND USING THEREOF - Described herein are modified gelatins or the pharmaceutically-acceptable salts or esters thereof comprising at least one actinically crosslinkable group covalently bonded to gelatin. The modified gelatins are useful in producing composites that ultimately can be used to produce three-dimensional engineered biological constructs. The composites are the polymerization product between the modified gelatin and at least one actinically crosslinkable macromolecule. Methods for making the modified gelatins are also described herein. | 07-04-2013 |
20130171062 | MAPPING IN VIVO EOSINOPHIL ACTIVATION IN EOSINOPHILIC ESOPHAGITIS - Provided are compositions and methods for diagnosing eosinophilic esophagitis in a mammalian subject. Further provided are methods of monitoring the course of eosinophilic esophagitis in a subject diagnosed with the disease. | 07-04-2013 |
20130164745 | Methods for Assessing Risk for Cardiac Dysrythmia in a Human Subject - The present invention relates to methods for assessing the risk of a patient for developing a potentially fatal cardiac dysrhythmia and for diagnosing Andersen's Syndrome. A tissue sample from a patient is obtained and the DNA or proteins of the sample isolated. From the DNA and protein isolates the sequence of the KCNJ2 gene or the Kir2.1 polypeptide can be obtained. The KCNJ2 gene or the Kir2.1 can be screened for alteration as compared to the wile-type sequence. An alteration in a copy of the KCNJ2 gene or a Kir2.1 polypeptide indicates that the patient has a high risk for developing a cardiac dysrhythmia and can be diagnosed with Andersen's Syndrome. The invention also related to isolated nucleic acid molecules with one or more alterations as compared to the wild-type sequence. | 06-27-2013 |
20130156722 | POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF - Described herein are biodegradable drug delivery conjugates for effectively delivering bioactive agents to a subject. The drug delivery conjugates comprise a water-soluble high molecular weight linear biodegradable polymer backbone comprising a plurality of linear water-soluble polymeric segments connected to one another by a first (main-chain) cleavable linker, wherein a bioactive agent is covalently bonded to at least one water-soluble polymeric segment, at least one cleavable linker, or a combination thereof. The conjugates possess numerous advantages over prior art delivery conjugates. Also described herein are methods for making and using the conjugates. | 06-20-2013 |
20130154776 | Control of Magnetically Actuated Tools in any Position Using a Rotating Magnetic Source - Systems and methods utilize a rotating magnetic field to drive a magnetically actuated device where the source of the rotating magnetic field is not constrained to a particular orientation with respect to the device. In one embodiment a rotating permanent magnet is utilized to actuate a magnetically actuated device where the magnet is not constrained to any position relative to the magnetically actuated device, such as the radial or axial position. Accordingly, the rotating permanent magnet may be directed in a manner to avoid collisions or other obstacles in a workspace while still effectively driving the magnetically actuated device. | 06-20-2013 |
20130147916 | MICROSCOPY SYSTEM AND METHOD FOR CREATING THREE DIMENSIONAL IMAGES USING PROBE MOLECULES | 06-13-2013 |
20130143821 | HYDROPHOBICALLY-MODIFIED HYALURONAN AND METHODS OF MAKING AND USING THEREOF - Described herein are modified hyaluronans or the pharmaceutically-acceptable salt or ester thereof, wherein the modified hyaluronan comprises at least one hydrophobic polypeptide covalently bonded to hyaluronan. The modified hyaluronans can be used as viscosupplements in a number of medical applications. The modified hyaluronans can also be used in several biological and medical applications. Methods for preparing the modified hyaluronans are also provided herein. | 06-06-2013 |
20130143320 | METHODS AND COMPOSITIONS FOR MANIPULATING THE GUIDED NAVIGATION OF ENDOTHELIAL TUBES DURING ANGIOGENESIS - Methods and compositions for manipulating the directed navigation of physiological tracking tubular structures are provided. A novel cell-bound receptor, roundabout-4 (Robo-4), is described. The Robo-4 receptor shows sequence and structural similarity to members of the roundabout family of receptors. Also, the Robo-4 receptor binds Slit ligand, a known receptor of the roundabout receptors. Polynucleotides and polypeptides of the Robo-4 receptor are described. | 06-06-2013 |
20130130299 | ELECTROCHEMICAL FLOW CYTOMETRY - A method for triggering cellular exocytosis events and measuring quantal release of electroactive chemicals is disclosed. A method can include flowing a cell through a single cell channel having a pair of electrodes oriented to direct current through the cell at a stimulation location along the single cell channel. The pair of electrodes include a working electrode, a counter electrode and an optional reference electrode. The single cell channel has dimensions which provide direct contact of the cell with walls of the single cell channel sufficient to substantially reduce or eliminate shunt paths around the cell at the stimulation location. The cell can be exposed to an electric field at the stimulation location using the pair of electrodes sufficient to trigger exocytosis. Changes in current due to exocytosis processes appear as spikes that can be correlated with a quanta of the electroactive chemicals which are released during exocytosis. | 05-23-2013 |
20130129797 | POLYMERIC COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF - Described herein are polymeric compositions that comprise at least one polymer residue and at least one crosslinking moiety, wherein the polymer residue is crosslinked by the crosslinking moiety and wherein the crosslinking moiety is formed from a reaction between a boronic acid moiety and a hydroxamic acid moiety. Also, described are methods of making and using such polymeric compositions. | 05-23-2013 |
20130129737 | Group B Streptococcus Polypeptides Nucleic Acids and Therapeutic Compositions and Vaccines Thereof - This invention provides an isolated nucleic acid encoding a polypeptide comprising amino acid sequences of a streptococcal matrix adhesion E (EmaE) polypeptide. Antibodies to the EmaE polypeptide and immunogenic fragments thereof are also provided. This invention provides pharmaceutical compositions, immunogenic compositions, vaccines, and diagnostic and therapeutic methods of use of the isolated polypeptide, antibodies thereto, and nucleic acids. | 05-23-2013 |
20130123605 | BRAIN PHOSPHORUS SPECTROSCOPY IN BIPOLAR DISORDER - Described herein are systems and methods of identifying bipolar disorder in a person. One such method includes acquiring | 05-16-2013 |
20130122301 | PRESSURE SENSITIVE MICROPARTICLES FOR MEASURING CHARACTERISTICS OF FLUID FLOW - Microparticles ( | 05-16-2013 |
20130113370 | Micro-Plasma Field Effect Transistors - In some aspects, a micro-plasma device comprises a plasma gas enclosure containing at least one plasma gas, a plasma generation circuit interfaced with the plasma gas enclosure, and a plurality of electrodes interfaced with the plasma gas enclosure. In other aspects, a micro-plasma circuitry apparatus comprises a first layer having plasma generating electrodes, a second layer having a cavity formed therein, and a third layer having a circuit formed therein. The circuit includes a micro-plasma circuit (MPC) that includes one or more micro-plasma devices (MPDs). A metallic layer covers the MPC except at locations of the MPDs. The first layer is bonded to the second layer and the second layer is bonded to the third layer, thereby forming an enclosure that contains at least one plasma gas. | 05-09-2013 |
20130109017 | MULTIPLE MYELOMA PROGNOSIS AND TREATMENT | 05-02-2013 |
20130102652 | METHODS AND COMPOSITIONS RELATED TO MODIFIED ADENOSINES FOR CONTROLLING OFF-TARGET EFFECTS IN RNA INTERFERENCE - Disclosed are compositions and methods related to modified nucleobases. Also disclosed are compositions and methods related to modified interfering RNAs. Also disclosed are compositions and methods related to modified adenonsine for controlling off-target effects in RNA interference. | 04-25-2013 |
20130102534 | COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY - Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of inhibiting vascular permeability and pathologic angiogenesis are also described herein. Pharmaceutical compositions are included in the compositions described herein. The compositions described herein are useful in, for example, methods of inhibiting vascular permeability and pathologic angiogenesis, including methods of inhibiting vascular permeability and pathologic angiogenesis induced by specific angiogenic, permeability and inflammatory factors, such as, for example VEGF, bFGF and thrombin. Methods for treating specific diseases and conditions are also provided herein. | 04-25-2013 |
20130101194 | Filtered Backprojection Image Reconstruction with Characteristics of an Iterative Map Algorithm - Systems and methods are provided which utilize a fast, efficient filtered backprojection algorithm that can provide noise suppression advantages of an iterative MAP reconstruction algorithm. In some embodiments novel filtered backprojection systems are able to provide an image which emulates an image from an iterative algorithm corresponding to a selected iteration by utilizing control parameters which shape the filter accordingly during the reconstruction process. For example, if a user desires an image which would correspond to the one-hundredth iteration of an iterative algorithm, embodiments can provide a similar quality image using minimal calculation steps. Further, embodiments may provide the resolution quality of such an iteration while also allowing for better shift-invariant performance than an iterative method. | 04-25-2013 |
20130099205 | HOMOGENEOUS MULTIPLE BAND GAP DEVICES - An electrical device comprising (A) a substrate having a surface and (B) a nanohole superlattice superimposed on a portion of the surface is provided. The nanohole superlattice comprises a plurality of sheets having an array of holes defined therein. The array of holes is characterized by a band gap or band gap range. The plurality of sheets forms a first edge and a second edge. A first lead comprising a first electrically conductive material forms a first junction with the first edge. A second lead comprising a second electrically conductive material forms a second junction with the second edge. The first junction is a Schottky barrier with respect to a carrier. In some instances a metal protective coating covers all or a portion of a surface of the first lead. In some instances, the first lead comprises titanium, the second lead comprises palladium, and the metal protective coating comprises gold. | 04-25-2013 |
20130098613 | GEOTHERMAL WELL DIVERSION AGENT FORMED FROM IN SITU DECOMPOSITION OF CARBONYLS AT HIGH TEMPERATURE - A method of selectively blocking fractures in a subterranean formation by injecting a diversion agent into the well is disclosed. According to one embodiment, the method comprises injecting a diversion agent into a subterranean formation to form an alkaline-earth carbonate precipitate from decomposition of a carbonyl compound, wherein the diversion agent includes the carbonyl compound and an alkaline-earth halide salt. | 04-25-2013 |
20130095327 | Device Comprising Deuterated Organic Interlayer - The present invention relates to devices that can be manipulated or controlled with a magnetic field, such as a spin-valve device, an organic light-emitting device, a compass, or a magnetometer. The devices of the invention comprise an organic interlayer comprising a deuterated organic material. | 04-18-2013 |
20130065241 | Methods And Compositions Related To Continuous Flow Thermal Gradient PCR - Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR. | 03-14-2013 |
20130053565 | SUBSTITUTED 3-PIPERIDONE COMPOUNDS - Described herein are methods for synthesizing substituted 3-piperidone compounds. Notably, substituted 3-piperidones can also be prepared in enantiopure form. The methods may allow for preparation of highly substituted piperidine cores. Also disclosed are 3-piperidone compounds and pharmaceutical compositions comprising the compounds. | 02-28-2013 |
20130053553 | HETEROCYCLIC COMPOUNDS - Described herein are methods for synthesizing heterocyclic, 8-membered ring structures. The methods may allow for preparation of highly substituted 8-membered rings. Also disclosed are heterocyclic, 8-membered ring compounds and pharmaceutical compositions comprising the compounds. | 02-28-2013 |
20130041449 | Virtual Electrodes for High-Density Electrode Arrays - The present embodiments are directed to implantable electrode arrays having virtual electrodes. The virtual electrodes may improve the resolution of the implantable electrode array without the burden of corresponding complexity of electronic circuitry and wiring. In a particular embodiment, a virtual electrode may include one or more passive elements to help steer current to a specific location between the active electrodes. For example, a passive element may be a metalized layer on a substrate that is adjacent to, but not directly connected to an active electrode. In certain embodiments, an active electrode may be directly coupled to a power source via a conductive connection. Beneficially, the passive elements may help to increase the overall resolution of the implantable array by providing additional stimulation points without requiring additional wiring or driver circuitry for the passive elements. | 02-14-2013 |
20130035307 | METHODS FOR TREATING OR PREVENTING THE SPREAD OF CANCER USING SEMI-SYNTHETIC GLYCOSAMINOGLYCOSAN ETHERS - Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEs”). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described. | 02-07-2013 |
20130023862 | IMAGE-GUIDED RENAL NERVE ABLATION - A method of treating hypertension in a mammal is described, including: by focused sound energy, heating at least one nerve at a surface of a renal artery in a mammal; during the heating and by magnetic resonance imaging, repeatedly determining thermal levels in each of first and second volumetric zones of a region that includes at least a portion of the surface, the second zone being adjacent to the first zone; after determining that an indicium of a thermal level in the first zone exceeds a first threshold, and upon determining that an indicium of a thermal level in the second zone exceeds a second threshold, ceasing the heating of the at least one nerve for at least three months; and as a result of the heating, lowering a blood pressure in the mammal. | 01-24-2013 |
20130017179 | Lineage-Restricted Neuronal Precursors - A cell population has been identified and isolated that can differentiate into multiple neuronal phenotypes, but cannot differentiate into glial phenotypes. This mammalian CNS neuron-restricted cell expresses highly polysialated or embryonic neural cell adhesion molecule (E-NCAM) and is morphologically distinct from neuroepithelial stem cells (NEP cells) and spinal glial progenitors derived from embryonic day 10.5 spinal cord. Methods for isolating these cells and uses thereof are also disclosed. | 01-17-2013 |
20120316657 | RELEASABLE ATTACHMENT SYSTEM FOR A PROSTHETIC LIMB - A releasable attachment system is provided for use with a bone anchored post and related external prosthesis such as a prosthetic limb or the like, wherein the attachment system includes a safety release mechanism designed to release or break away when encountering an excess mechanical load. The bone anchored mounting post is implanted for direct affixation to patient bone, and carries or is connected to a fixator structure protruding through soft skin tissue and the like at the end or stump of an amputated limb for mechanical connection to the external prosthesis. The safety release mechanism accommodates substantially normal patient movement throughout a corresponding range of substantially normal mechanical loads, but releases in the presence of an excess load to prevent undesirable fracture failures. | 12-13-2012 |
20120301855 | Method and System for Automating the Scoring of Task Information - A method and system for scoring task information. Through the use of an electronic time management device, such as a cell phone or other portable digital computer based device programmed to support this method, a user enters a description of a task and when the task should be completed. This information is then communicated to a scoring system, and the information is scored without human intervention and points are given. Optionally, if the information cannot be automatically scored, it is scored by a person. These points can be banked and then be used toward a socially desirable reward, such as sending text messages or playing music or watching videos. This is particularly effective in teaching time management skills to young students who may have attention deficit hyperactivity disorder (ADHD). | 11-29-2012 |
20120280685 | Linear Phase Microstrip Radio Frequency Transmit Coils - Systems, devices and methods provide an RF coil which produces a field having linear phase variation across an imaging volume. In one embodiment, a coil comprises multiple microstrip elements configured to have an increased effective electrical length. This increase in electrical length allows for a larger linear phase shifts over the length of the microstrip element which in turn increases linear phase variation capabilities. This may be accomplished by increasing the effective dielectric properties of the microstrip element. Increasing the effective dielectric may be accomplished by utilizing distributed capacitors along the length of a microstrip element (e.g. lumped element capacitors), by altering the materials used to fabricate the microstrip element, etc. Additionally, increasing the effective dielectric may be accomplished using a combination of these means. Embodiments may further enable linear phase variation along the imaging volume at high frequencies, such as frequencies utilized for 3 T and above MRI devices. | 11-08-2012 |
20120265086 | ELECTROCARDIOGRAPHIC ASSESSMENT OF ARRHYTHMIA RISK - Systems and methods are provided in the disclosure for estimating a risk of arrhythmia in a patient using electrocardiographic analysis. In certain aspects, a method of estimating a risk of arrhythmia in a patient is provided. The method comprises receiving electrocardiographic signals of the patient from a plurality of leads over a plurality of heart beats, averaging the electrocardiographic signals to produce an averaged electrocardiographic signal, and determining deflections in the averaged electrocardiographic signal, wherein each deflection has an amplitude and a duration. The method further comprises determining a significance of each deflection based on whether the amplitude of that deflection exceeds a threshold, and estimating a risk of arrhythmia in the patient based on at least one of a number, the amplitudes, and the durations of the significant deflections within a portion of the averaged electrocardiographic signal. | 10-18-2012 |
20120228958 | Apparatus, System, and Method for Multicoil Telemetry - An apparatus, system, and method for multicoil telemetry are disclosed. In one embodiment, the apparatus includes an intermediate coil disposed between a driving coil and a receiving coil, where the intermediate coil is configured to act on magnetic fields between the driving coil and receiving coil in order to provide improved coupling efficiency. The improved coupling may assist in providing efficient power transfer and/or data transfer utilizing the magnetic fields. In some embodiments the receiving coil may be in direct communication with the intermediate coil, without any other intermediate coils. In some embodiments, the apparatus includes a second intermediate coil disposed between the driving coil and receiving coil to improve the transfer efficiency between the driving and receiving coils. The intermediate coils may have a high quality factor and be configured to decouple the resistance between the driving and receiving coils. | 09-13-2012 |
20120220539 | CONOTOXIN PEPTIDES - The present invention relates conotoxin peptides that are analogs of the α-contoxin peptide RgIA. These conotoxin peptides block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) and can be used for treating pain, such as neuropathic pain and inflammatory pain, inflammatory disorders, such as rheumatic diseases, and in the treatment of breast cancer. | 08-30-2012 |
20120215122 | ARRHYTHMIA INFORMATION MANAGEMENT - Systems and methods for managing cardiac information concerning a patient are provided. In some aspects, cardiac information objects are displayed graphically at an interface having at least two axes. Time is displayed on a first axis of the at least two axes and parameters of the cardiac information objects are displayed on a second axis of the at least two axes. Each cardiac information object is spatially associated with at least a portion of the time displayed and a parameter displayed. In some aspects, the interface advantageously allows a user to conveniently view and manage the cardiac information objects. | 08-23-2012 |
20120203253 | SYSTEM FOR TISSUE FIXATION TO BONE - Methods and systems are provided for fixating connective tissue to bone. Some aspects include a carrier member having a length, width, and thickness, wherein the length and width are each at least two times greater than the thickness; attachment members extending from the carrier member and that engage connective tissue of an animal; and a bone engaging member extending from the carrier member and configured to attach to a bone of the animal. In some aspects, when the attachment members are engaged with the connective tissue and the bone engaging member is attached to the bone, the connective tissue and the bone are limited in being pulled apart from one another during physiological use of the connective tissue. | 08-09-2012 |
20120201428 | IMAGE RECONSTRUCTION INCORPORATING ORGAN MOTION - Systems and methods which implement an image reconstruction framework to incorporate complex motion of structure, such as complex deformation of an object or objects being imaged, in image reconstruction techniques are shown. For example, techniques are provided for tracking organ motion which uses raw time-stamped data provided by any of a number of imaging modalities and simultaneously reconstructs images and estimates deformations in anatomy. Operation according to embodiments reduces artifacts, increase the signal-to-noise ratio (SNR), and facilitates reduced image modality energy dosing to patients. The technology also facilitates the incorporation of physical properties of organ motion, such as the conservation of local tissue volume. This approach is accurate and robust against noise and irregular breathing for tracking organ motion. | 08-09-2012 |
20120197060 | RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY TECHNOLOGY - Described herein are anti-cancer compounds composed of a macromolecule comprising (1) at least one anti-cancer agent directly or indirectly bonded to the macromolecule and (2) at least one high Z element directly or indirectly bonded to the macromolecule that is capable of producing Auger electrons upon exposure to X-ray energy. When the compounds are exposed to low energy X-ray (e.g., kilo electron volts KeV) Auger electrons are produced by the high Z elements present in the compound. Because lower energy is required when compared to typical radiotherapy, which uses therapeutic X-ray energy in the million electron volt range (MeV), the subject experiences lower collateral damage when compared to radiation therapy. Additionally, the presence of the anti-cancer agent provides a second mechanism for killing cancer cells. Methods for making and using the anti | 08-02-2012 |
20120195488 | Methods and Compositions Related to Cellular Assays - The present invention relates generally to the fields of molecular biology and cancer. More specifically, the invention concerns methods and compositions useful for diagnosing and assessing a subject's response to therapy. | 08-02-2012 |
20120187947 | SLICE SELECTIVE MRI EXCITATION WITH REDUCED POWER DEPOSITION USING MULTIPLE TRANSMIT CHANNELS - Described are embodiments for slice-selective excitation for MRI that utilize multiple RF transmit coils, each of which are driven with a separate independent current waveform. These embodiments allow slice-selective excitation with slice profile and excitation time similar to other single-channel excitation, but with reduction in SAR caused by the transverse component of the RF field by a factor up to the number of excitation coils. | 07-26-2012 |
20120179030 | DEVICES AND METHODS FOR FLUORESCENT INSPECTION AND/OR REMOVAL OF MATERIAL IN A SAMPLE - An apparatus is provided that includes a light-emitting component, a light-detecting component, a lock-in amplifier, a frequency generator that is operatively linked to the lock-in amplifier and the light-emitting component, a speaker capable of emitting an audio signal wherein the output audio signal varies depending on the detected fluorescence in the sample, and a visible output of relative fluorescent intensity where the visible output varies depending on the detected fluorescence in the sample. The apparatus may also include a laser that is operatively coupled to the lock-in amplifier through a control switch, and focusing lens or an additional type of filter such as an interference filter, a short-pass filter, a notch filter, a long-pass filter or an infrared filter. The apparatus may be used to identify and/or to remove fluorescent or non-fluorescent material from a sample. Associated methods are also disclosed. | 07-12-2012 |
20120177918 | SIMPLE ADHESIVE COACERVATES AND METHODS OF MAKING AND USING THEREOF - Described herein is the synthesis of adhesive from simple adhesive coacervates and their uses thereof. The adhesives are produced by (a) preparing a solution comprising (1) a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, the polyeletrolyte comprises at least one crosslinking group, and (2) a sufficient amount of a complimentary counterion to produce a simple adhesive coacervate; and (b) crosslinking the simple adhesive coacervate to produce the adhesive. The adhesives have numerous medical and non-medical applications. | 07-12-2012 |
20120152832 | SUBMERGED SYSTEM AND METHOD FOR REMOVAL OF UNDESIRABLE SUBSTANCES FROM AQUEOUS MEDIA - A system and method are provided for removal of undesirable substances from a body of liquid. The system can include an aeration structure having a continuously inclined surface configured to provide an interaction of air bubbles against substantially an entire length of the continuously inclined surface while the air bubbles are moving toward a top of the body of liquid. The continuously inclined surface can be substantially submerged in the body of liquid. A bio-film of diverse bacteria colonies is disposed on the continuously inclined surface, and a high surface area-to-volume structure is located in proximity to the aeration structure, upon which a bio-film of bacteria colonies can be formed. An aeration system is coupled to an air supply system which releases the air bubbles toward a bottom of the continuously inclined surface, such that the air bubbles move along the continuously inclined surface as they rise so as to (i) create a variety of aerobic-anaerobic conditions at the bio-film and (ii) engage the air bubbles in a continuous mixing of a micro climate for the bio-film in response to an orientation of the continuously inclined surface and (iii) provide airlift circulation of water from bottom to top of the aeration structure. | 06-21-2012 |
20120149041 | IDENTIFICATION AND QUANTIFICATION OF BIOMARKERS FOR EVALUATING THE RISK OF PRETERM BIRTH - Described herein are methods for evaluating the risk of preterm birth in pregnant subjects. The methods involve detecting and quantifying a first biomarker and a second biomarker associated with preterm birth in a biological sample from the subject. Also described herein are isolated biomarkers and kits useful in predicting the risk of preterm birth. | 06-14-2012 |
20120138335 | High Aspect Ratio Microelectrode Arrays Enabled to Have Customizable Lengths and Methods of Making the Same - A method of fabricating an array of micro electrodes enabled to have customizable lengths. A substantially criss-cross pattern of channels on a top surface of the work-piece substrate ( | 06-07-2012 |
20120135399 | CANCER BIOMARKER AND METHODS OF USING THEREOF - Described herein are biomarkers which can be used for identifying a subject at risk for or evaluating the progression of cancer. In certain aspects, these biomarkers can be used to identify cancer stem cells. These biomarkers can include, but are not limited to, Oc1 or molecular variants thereof, Oc1 target proteins, or a combination thereof. In addition, described herein are methods for reducing the expression of these biomarkers associated with cancer. | 05-31-2012 |
20120132891 | PRECISION QUANTUM DOT CLUSTERS - Precision quantum dot clusters and methods for producing and tuning quantum dot clusters are described herein. Also described herein are materials and devices, including photovoltaic devices, that may include one or more quantum dot clusters. | 05-31-2012 |
20120128554 | METHODS FOR AGGLOMERATING ORES - A method for making an agglomerate of an ore is disclosed. The method comprises contacting the ore with an acid solution and a stucco binder. The stucco binder may include calcium sulfate hemihydrate. The ore agglomerate may include ore, acid solution, and stucco-derived gypsum. | 05-24-2012 |
20120122803 | ALPHA-CONOTOXIN MII ANALOGS - The invention relates to novel conopeptides and/or novel uses of conopeptides. The conopeptides of the invention are analogs of α-Conotoxin MII that are selective for α6-containing nAChRs as described herein. | 05-17-2012 |
20120121719 | METHODS OF MAKING AND USING THREE-DIMENSIONAL EXTRACELLULAR MATRICES - Three-dimensional extracellular matrices lacking synthetic scaffolds are provided. Methods of making the three-dimensional extracellular matrices and methods of using the three-dimensional extracellular matrices are also provided. | 05-17-2012 |
20120095077 | METHODS AND COMPOSITIONS RELATED TO MODIFIED GUANINE BASES FOR CONTROLLING OFF-TARGET EFFECTS IN RNA INTERFERENCE - Disclosed are compositions and methods related to modified nucleobases. Also disclosed are compositions and methods related to modified interfering RNAs. Also disclosed are compositions and methods related to modified guanine bases for controlling off-target effects in RNA interference. | 04-19-2012 |
20120090533 | LOW-TEMPERATURE SYNTHESIS OF COLLOIDAL NANOCRYSTALS - Low-temperature organometallic nucleation and crystallization-based synthesis methods for the fabrication of semiconductor and metal colloidal nanocrystals with narrow size distributions and tunable, size- and shape-dependent electronic and optical properties. Methods include (1) forming a reaction mixture in a reaction vessel under an inert atmosphere that includes at least one solvent, a cationic precursor, an anionic precursor, and at least a first surface stabilizing ligand while stirring at a temperature in a range from about 50° C. to about 130° C. and (2) growing nanocrystals in the reaction mixture for a period of time while maintaining the temperature, the stirring, and the inert-gas atmosphere. | 04-19-2012 |
20120089113 | INTRAOCULAR DRUG DELIVERY DEVICE AND ASSOCIATED METHODS - Devices, systems, and methods for delivery of an active agent into the eye of a subject can include an ocular active agent delivery device ( | 04-12-2012 |
20120084068 | Incorporation of Uncertainty in Simulation Analysis - A computing device simulates a test system by defining parameter values to be used to populate certain modeling formulas defining the test system. The defined parameter values correspond to one of the many points defining a domain in which the test system is to be simulated. The simulation iteratively solves the modeling formulas for each unit of the test system model space for each point in the domain in which the test system is simulated. Results for the subjects of interest are calculated at each iteration using the populated modeling formulas. A variance of the subjects of interest is also calculated at each iteration using a correlation coefficient obtained for the subjects of interest. The iterations of defining the parameter values and calculating the value and variance of the subjects of interest in the test system model space continues until all points in the domain have been simulated. | 04-05-2012 |
20120083687 | Retrospectively Correlated Turbo Spin Echo Imaging - Systems and methods which generate a sequence of images using turbo spin echo magnetic resonance imaging which are retrospectively correlated with periodic motion occurring within a subject being imaged are described. In one embodiment, k-space measurements (or the measurements from which images are formed) are captured during, and correlated with, different phases in a cardiac cycle of the subject. With this sequence, the images that are produced are able to show, and/or compensate for, motion correlated with the cardiac cycle of the subject. | 04-05-2012 |
20120083465 | METHOD FOR BLOCKING LIGATION OF THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS (RAGE) - A method and medicament is provided for treating and inhibiting interaction of the receptor for advanced glycation end-products (RAGE) and its ligands using a natural or synthetic sulfated polysaccharide, preferably a 2-O desulfated heparin. The medicament preferably is administered intravenously, by aerosolization, intra-nasally, intra-articularly, intra-thecally, subcutaneously, topically or orally. The medicament is useful for treating a variety of conditions, including diabetes, inflammation, renal failure, aging, systemic amyloidosis, Alzheimer's disease, inflammatory arthritis, atherosclerosis, and colitis. | 04-05-2012 |
20120082355 | Intrinsic Detection of Motion in Segmented Sequences - A self-navigating technique designed to detect motion in segmented sequences is disclosed. Certain embodiments compare a plurality of segments containing adjacent sets of k-space lines and produce an aliased error function which corresponds to a correlation of the segments. A global shift of the aliased error function may indicate the presence of in-plane rigid-body translation while other types of motion are evident in the dispersion or breadth of the error function. Some embodiments may then replace motion corrupted data with reacquired data. Further, some embodiments may correct or remove corrupted data retrospectively. | 04-05-2012 |
20120070443 | PDE1 AS A TARGET THERAPEUTIC IN HEART DISEASE - Disclosed are compositions and methods related to inhibition of PDE1. | 03-22-2012 |
20120068126 | POST-SYSTHESIS MODIFICATION OF COLLOIDAL NANOCRYSTALS - Methods for precise and predictable modification of previously synthesized nanocrystals. The methods rely on the solubility behavior of crystalline materials to provide for controlled reversal of the nanocrystal growth process (i.e., dissolution). A method for post-synthesis modification of colloidal nanocrystals includes (1) providing a first nanocrystal having a first size and a first shape, (2) forming a reaction mixture that includes the nanocrystal, at least one ligand capable of binding to at least one component of the nanocrystal, at least one solvent, and an inert gas atmosphere, and (3) modifying the size and/or shape of the nanocrystal in the reaction mixture for a period of time at a temperature in a range from about 100 0C to about 240 0C so as to produce at least a second nanocrystal having a second size and/or a second shape. | 03-22-2012 |
20120058161 | ALKYLATED SEMI SYNTHETIC GLYCOSAMINOGLYCOSAN ETHERS, AND METHODS FOR MAKING AND USING THEREOF - Described herein are alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated and alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including use for ocular or ophthalmic treatment. | 03-08-2012 |
20120046261 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND PREVENTING SPONTANEOUS PRETERM BIRTH - Disclosed herein are compositions and methods of identifying a subject at risk for preterm birth and selecting effective therapies for preventing preterm birth in the subject. The disclosed methods generally involve determining the identity of one or more nucleotides in the progesterone receptor (PR) gene of the subject. | 02-23-2012 |
20120039765 | DISINFECTING CAPS AND SYSTEMS AND ASSOCIATED METHODS - Caps can be used to cover and disinfect a male protrusion portion of a medical connector. Some caps can create a seal with the male protrusion to prevent antiseptic from entering a lumen the protrusion. A biasing element can aid in creating or maintaining the seal. | 02-16-2012 |
20120039764 | DISINFECTING CAPS AND SYSTEMS AND ASSOCIATED METHODS - Caps can be used to cover and disinfect a male protrusion portion of a medical connector. Some caps can create a seal with the male protrusion to prevent antiseptic from entering a lumen the protrusion. A biasing element can aid in creating or maintaining the seal. | 02-16-2012 |
20120021968 | METHODS FOR TREATING OR PREVENTING UROLOGICAL INFLAMMATION - Described herein are methods for treating or preventing urological inflammation in a subject comprising administering to the subject an effective amount of a compound comprising
| 01-26-2012 |
20110318738 | IDENTIFICATION AND REGULATION OF A NOVEL DNA DEMETHYLASE SYSTEM - Disclosed herein are methods and systems directed at detecting, evaluating, ameliorating, preventing and treating an oncogenic event. The disclosed methods and systems can comprise one or more Demethylase System Components or other compositions that can be used alone or in combination to detect, evaluate, treat, ameliorate, or prevent an oncogenic event. | 12-29-2011 |
20110306581 | STABLE PERFLUOROCARBON EMULSION FOR USE AS AN ARTIFICIAL OXYGEN CARRIER - Perfluorocarbon emulsions having a high stability and good oxygen release are disclosed and described. These perfluorocarbon emulsions are typically for use as artificial oxygen carriers. The perfluorocarbon emulsions include a disperse phase of a perfluorocarbon and an emulsion stabilizer, and continuous phase. The emulsion stabilizer can primarily include a poly(ethylene oxide) block copolymer. These stabilized perfluorocarbon emulsions can be used in liquid and/or hydrogel phases of perfusion bioreactors or various other culture systems to enhance cell viability in thick tissue constructs, or as blood substitutes, although other applications may also be considered. | 12-15-2011 |
20110301438 | DYE APPLICATION FOR CONFOCAL IMAGING OF CELLULAR MICROSTRUCTURE - A system and method for confocal imaging of tissue in vivo and in situ, e.g., for minimally invasive diagnosis of patients. A catheter is provided that has a dye carrier coupled to the distal end of a fiber optics bundle, which allows for the introduction of at least one fluorescent dye therein the dye carrier into a portion of the tissue of interest of a subject or patient when the dye carrier is selectively brought into contact with the portion of the tissue of interest. The resulting confocal images permit the acquisition of diagnostic information on the progression of diseases at cellular/tissue level in patients. Furthermore, a system for ECG-triggered image acquisition is provided. | 12-08-2011 |
20110294520 | System and Method for Preventing Cell Phone Use While Driving - A system for monitoring and controlling the use of a mobile computing device is disclosed. The system includes a data server ( | 12-01-2011 |
20110288566 | TISSUE STABILIZATION SYSTEM - Methods and systems are provided for tissue stabilization. Some aspects include a carrier member having a length, width, and thickness, wherein the length and width are each at least two times greater than the thickness; attachment members extending from the carrier member and that engage connective tissue; and stabilizing members, each of which can couple a respective attachment member to the carrier member and is substantially positionally fixed relative to the carrier member. | 11-24-2011 |
20110288565 | TISSUE FIXATION - Methods and apparatuses are provided for tissue fixation. In some aspects, an apparatus includes: a carrier member having a first part, a second part, and a junction therebetween; first attachment members protruding at a first angle from the first part toward the junction, where the first attachment members are configured to engage a first portion of connective tissue for attaching the first part to the first portion; and second attachment members protruding from the second part, where the second attachment members are configured to engage a second portion of connective tissue for attaching the second part to the second portion. When the first part is attached to the first portion and the second part is attached to the second portion, the first portion and the second portion are limited in being pulled apart from one another during physiological use of the connective tissue. | 11-24-2011 |
20110287923 | HIGH-TOUGHNESS ZETA-PHASE CARBIDES - A ceramic material having a high toughness can include carbon and a transition metal. The transition metal can have an elemental body centered cubic structure at room temperature. A substantial amount of the ceramic can be of a rhombohedral ζ phase of the transition metal and carbon. These materials can have a high thermal shock resistance, high fracture toughness, and good high temperature performance. A particulate mixture of a carbon source and a transition metal source can be assembled ( | 11-24-2011 |
20110280914 | HYDROGELS CROSSLINKED WITH GOLD NANOPARTICLES AND METHODS OF MAKING AND USING THEREOF - Described herein are composites useful in tissue and organ engineering. In one aspect, the composite comprises the reaction product between a macromolecule comprising at least one thiol group and a gold nanoparticle. The thiolated macro-molecule crosslinks with the gold nanoparticle to produce a composite that is useful in anchoring cells. The composites can be used to form multi-layer 3-D structures, where the cells in each layer can aggregate and fuse with one another to form tissues and organs. | 11-17-2011 |
20110278000 | GEOTHERMAL WELL DIVERSION AGENT FORMED FROM IN SITU DECOMPOSITION OF CARBONYLS AT HIGH TEMPERATURE - A method of selectively blocking fractures in a subterranean formation by injecting a diversion agent into the well is disclosed. According to one embodiment, the method comprises injecting a diversion agent into a subterranean formation to form an alkaline-earth carbonate precipitate from decomposition of a carbonyl compound, wherein the diversion agent includes the carbonyl compound and an alkaline-earth halide salt. | 11-17-2011 |
20110274356 | IMAGE PATTERN RECOGNITION - Image pattern recognition is described. In accordance with one embodiment, a method for image recognition includes dividing an image into blocks in preparation for separating a region of interest of the image from the remainder of the image. The blocks can be analyzed to determine whether a two dimensional projection of data from one or more blocks has a circular shape. The region of interest can be identified by identifying the blocks with circular shaped projections. | 11-10-2011 |
20110272503 | SYSTEMS AND PROCESSES FOR PRODUCING HIGH PURITY TRONA - A process of producing high purity trona concentrate includes crushing a mined raw trona ( | 11-10-2011 |
20110269713 | BRYOSTATIN ANALOGUES AND METHODS OF MAKING AND USING THEREOF - Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity. | 11-03-2011 |
20110263483 | COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY - Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of inhibiting vascular permeability and pathologic angiogenesis are also described herein. Pharmaceutical compositions are included in the compositions described herein. The compositions described herein are useful in, for example, methods of inhibiting vascular permeability and pathologic angiogenesis, including methods of inhibiting vascular permeability and pathologic angiogenesis induced by specific angiogenic, permeability and inflammatory factors, such as, for example VEGF, bFGF and thrombin. Methods for treating specific diseases and conditions are also provided herein. | 10-27-2011 |
20110263025 | BIODEGRADABLE POLYDISULFIDE AMINES FOR GENE DELIVERY - Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(N,N′-cystaminebisacrylamide-spermine), poly(N,N′-cystaminebisaciylamide-N,N′-bis(3-aminopropyl)1,3-propanediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(3-amino-propyl)ethylenediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(2-aminoethyl)-1,3-propanediamine), and poly(N,N′-cystaminebisacrylamide-triethylenetetramine). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and protected oligoamine monomers, followed by deprotection. Complexes are formed by mixing the poly(disulfide amine)s with a nucleic acid. Delivery of the nucleic acid into cells is carried out by contacting the cells with the nucleic acid/poly(disulfide amine) complexes. | 10-27-2011 |
20110262395 | SENSORY RECEPTORS FOR CHRONIC FATIGUE AND PAIN AND USES THEREOF - The present invention relates generally to the fields of pathological muscle pain/fatigue conditions. More specifically, the invention concerns methods and compositions useful for diagnosing and treating pathological muscle pain/fatigue conditions. | 10-27-2011 |
20110251135 | INHIBITORS OF PERITONEAL SEEDING OF CANCER CELLS - Disclosed compositions and methods for inhibiting NF-κB mediated cellular proliferation and metastasis. | 10-13-2011 |
20110247404 | IDENTIFYING AND QUANTIFYING BIOMARKERS ASSOCIATED WITH PREECLAMPSIA - Described herein are methods for testing pregnant subjects for preeclampsia by detecting and quantifying at least one biomarker associated with preeclampsia in a biological sample from the subject. | 10-13-2011 |
20110244434 | System and Method of Analyzing Freeform Mathematical Responses - A system and method are provided of analyzing a response expression in a freeform format as entered by a student in response to testing and practice questions presented by a computer system. The method can include parsing the response expression into tokens stored in a response expression tree. The system can determine whether the response expression tree is legal based on a defined grammar structure. Another operation is comparing a numerical evaluation of the response expression to a numerical evaluation of a reference expression. The similarity between the response expression and the reference expression can then be determined by comparing the response expression tree and a reference expression tree. Feedback can be supplied to the student regarding the overall correctness of the response expression as compared to the reference expression, based on correctness of each response expression element and the types of errors among response elements. | 10-06-2011 |
20110237838 | PROCESSES FOR CATALYTIC CONVERSION OF LIGNIN TO LIQUID BIO-FUELS AND NOVEL BIO-FUELS - Processes for conversion of lignin to products such as phenolic compounds and biofuels prepared from such phenolic compounds are disclosed and described. A process for conversion of a lignin material to bio-fuels can include subjecting the lignin material to a base catalyzed depolymerization reaction to produce a partially depolymerized lignin. The partially depolymerized lignin can then be subjected to a stabilization/partial hydrodeoxygenation reaction to form a partially hydrodeoxygenated product. Following partial hydrodeoxygenation, the partially hydrodeoxygenated product can be reacted in a hydroprocessing step to form a bio-fuel. Each of these reaction steps can be performed in single or multiple steps, depending on the design of the process. The production of an intermediate partially hydrodeoxygenation product and subsequent reaction thereof can significantly reduce or eliminate reactor plugging and catalyst coking. A variety of useful bio-fuels such as fuels, fuel additives, and the like, including gasoline and jet or rocket fuels are describe which can be readily produced from renewable lignin materials in an improved conversion process. | 09-29-2011 |
20110207232 | WATER SOLUBLE PH RESPONSIVE FLUORESCENT NANOPARTICLES - A nano-pH sensor can include a nanoparticle having an outer surface functionalized by a carboxy functional group. The nanoparticle is reversibly aggregated as a function of pH and is generally non-toxic. A fluorometer can be oriented to expose the nanoparticles to a light source at a given wavelength. Further, the fluorometer can be configured to detect changes in fluorescence of the gold nanoparticle with changes in pH. | 08-25-2011 |
20110206756 | DITHIOCARBAMATE METAL CHELATES AND METHODS OF MAKING AND USING THEREOF - Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) a dithiocarbamate metal chelate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. Methods for using the compositions in anticancer treatment and prevention are also described herein. | 08-25-2011 |
20110189769 | METHODS AND COMPOSITIONS FOR MANIPULATING THE GUIDED NAVIGATION OF ENDOTHELIAL TUBES DURING ANGIOGENESIS - Methods and compositions for manipulating the directed navigation of physiological tracking tubular structures are provided. A novel cell-bound receptor, roundabout-4 (Robo-4), is described. The Robo-4 receptor shows sequence and structural similarity to members of the roundabout family of receptors. Also, the Robo-4 receptor binds Slit ligand, a known receptor of the roundabout receptors. Polynucleotides and polypeptides of the Robo-4 receptor are described. | 08-04-2011 |
20110182978 | ACTIVATED NITRIC OXIDE DONORS AND METHODS OF MAKING AND USING THEREOF - Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) an O | 07-28-2011 |
20110178720 | METHOD AND SYSTEM FOR MEASURING ENERGY EXPENDITURE AND FOOT INCLINE IN INDIVIDUALS - A method and system for measuring energy expenditure of individuals by measuring force from a plurality of foot-borne force sensitive resistors and calculating incline from a foot-borne tri-axial accelerometer. | 07-21-2011 |
20110177005 | STABLE NANOEMULSIONS FOR ULTRASOUND-MEDIATED DRUG DELIVERY AND IMAGING - Described herein are nanoemulsions comprising (1) at least one fluoro ether and (2) a block copolymer comprising a hydrophilic block and hydrophobic block, wherein the nanoemulsion comprises a therapeutic agent in the nanoemulsion. The nanoemulsions are stable and are excellent drug delivery devices for ultrasound-mediated, image guided drug delivery. Also described herein are methods for using the nanoemulsions to treat tumors and cancers as well as using them as imaging agents. | 07-21-2011 |
20110137147 | MINIMUM TIME FEEDBACK CONTROL OF EFFICACY AND SAFETY OF THERMAL THERAPIES - A thermal treatment control system including an imaging device for specifying the geometry and/or location of the treatment target, a thermal energy element for applying a thermal treatment for the heating or cooling of a target tissue for therapeutic purposes, a thermal energy detecting element for detecting a measured tissue response to the thermal treatment and a feedback controller for a real-time modification of the intensity and spatial distribution of the thermal dose in order to achieve therapeutic efficacy over a minimum or reduced treatment time while satisfying treatment constraints imposed to limit damage to normal tissues. | 06-09-2011 |
20110118751 | Integrated Surgical Cutting System - Integrated surgical systems and methods for using same are provided that can receive scanned images and produce a three dimensional model from the images. Based at least in pan on the three dimensional model, a processor generates code defining an optimized tool path, which is sent to a surgical machining system that can machine the desired portion of the patient. In one exemplary aspect, the integrated system operates in a clearly defined and pre-programmed manner with no necessity for in-situ sensory or guidance feedback. | 05-19-2011 |
20110112053 | PHARMACOLOGICAL TARGETING OF VASCULAR MALFORMATIONS - Disclosed herein are compositions and methods for decreasing vascular permeability in a blood vessel and treating or preventing conditions associated with defects or injuries of vascular endothelium. For example, the disclosed compositions and methods can be used to treat a vascular dysplasia such as cerebral cavernous malformation (CCM). These methods relate generally to the use of compositions that inhibit RhoA GTPase levels or activity, such as inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. | 05-12-2011 |
20110093161 | INTEGRATED SYSTEMS AND METHOD FOR PREVENTING MOBILE COMPUTING DEVICE USE WHILE DRIVING - A system and method for controlling use of a mobile computing device in a vehicle are disclosed. The method comprises monitoring a vehicle-key system comprising a vehicle and a vehicle key having a particular code to determine when the vehicle has been activated using the vehicle key. An operational state of the vehicle is identified based on information received from an OBD port in the vehicle. The operational state of the vehicle is communicated to the mobile computing device. Use of selected device features on the mobile computing device are controlled based on the particular code of the vehicle key when the operational state of the vehicle indicates that the vehicle is outside of selected parameters. | 04-21-2011 |
20110085979 | CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS - Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. | 04-14-2011 |
20110084693 | SYSTEMS AND METHODS FOR IMAGE RECONSTRUCTION OF SENSITIVITY ENCODED MRI DATA - Methods and systems in a parallel magnetic resonance imaging (MRI) system utilize sensitivity-encoded MRI data acquired from multiple receiver coils together with spatially dependent receiver coil sensitivities to generate MRI images. The acquired MRI data forms a reduced MRI data set that is undersampled in at least a phase-encoding direction in a frequency domain. The acquired MRI data and auto-calibration signal data are used to determine reconstruction coefficients for each receiver coil using a weighted or a robust least squares method. The reconstruction coefficients vary spatially with respect to at least the spatial coordinate that is orthogonal to the undersampled, phase-encoding direction(s) (e.g., a frequency encoding direction). Values for unacquired MRI data are determined by linearly combining the reconstruction coefficients with the acquired MRI data within neighborhoods in the frequency domain that depend on imaging geometry, coil sensitivity characteristics, and the undersampling factor of the acquired MRI data. An MRI image is determined from the reconstructed unacquired data and the acquired MRI data. | 04-14-2011 |
20110082104 | ALKYLATED SEMI SYNTHETIC GLYCOSAMINOGLYCOSAN ETHERS, AND METHODS FOR MAKING AND USING THEREOF - Described herein is the synthesis of alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including wound healing, drug delivery, and the treatment of a number of inflammatory diseases and skin disorders. | 04-07-2011 |
20110078036 | Systems and methods for the assessment, protection, marketing and commercialization of technology-based ideas - The operations, methods and functions of a technology-based idea assessment, protection and connection system are described. The system involves new methods and computer based algorithms and networks to value technology based ideas, complete a quality assessment of the technology-based idea, package the technology-based idea and determine a cost-based strategy for protection of technology-based idea. The software-as-a-service system determines an output of an idea generator's strength in his technology or research network and suggests a path to commercialization. A protected technology-based idea is matched with a product development outlet such as a company, entrepreneur or executive manager to produce a faster commercialization outlet. The services and tools for the creation of technology-based start-ups are described. The system streamlines the costly and complicated process of technology commercialization by automatically aligning human and financial resources. | 03-31-2011 |
20110064668 | J-SUPERFAMILY CONOTOXIN PEPTIDES - The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors. | 03-17-2011 |
20110064326 | SYSTEMS AND METHODS FOR DEBLURRING DATA CORRUPTED BY SHIFT VARIANT BLURRING - The present invention provides methods, systems and machine readable medium including machine readable code for deblurring data corrupted by shift variant blurring. A first version of data having shift variant blurring characterized by a first shift variant point spread function is provided. A target shift invariant point spread function is selected. A second shift variant point spread function is derived wherein a combination of the first and second shift variant point spread functions generates the target shift invariant point spread function. The second shift variant point spread function is applied to the first version of the data thereby generating a second version of the data having shift invariant blurring characterized by the target shift invariant point spread function. A linear shift invariant filter is applied to the second version of the data thereby generating a deblurred version of the data. | 03-17-2011 |