UNIVERSITY OF ROCHESTER Patent applications |
Patent application number | Title | Published |
20160136260 | ATTENUATED INFLUENZA VACCINES AND USES THEREOF - Provided herein are attenuated influenza viruses and methods of making attenuated influenza viruses. | 05-19-2016 |
20160128657 | Portable Cadmium Zinc Telluride (CZT) Image Identification System - There is provided a portable cadmium zinc telluride image identification system that uses an X-ray source with a novel sensing mitt that can be worn or held by the user. The sensing mitt is connected to a display that may be a stand-alone display, worn as glasses or otherwise integrated into the sensing mitt. The sensing mitt contains a detector array such as, but not limited to, a cadmium zinc telluride crystal or a plurality of crystals in a matrix. A collimator is placed in front of the sensing surface of the cadmium zinc telluride crystal and a processor is used to convert a representation of the electrical signals received from the cadmium zinc telluride crystal or similar detector array into display signals that are used by the display to provide an image of the subject of interest. | 05-12-2016 |
20160115124 | SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE - Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection. | 04-28-2016 |
20160091605 | Superresolution Imaging Of Scatterers In Pulse-Echo Imaging With Symmetric Stabilized Pulses - Systems and methods of pulse-echo imaging using stabilized symmetric pulses are described. The systems and methods are based on the development of a class of symmetric, i.e., two sided, functions that can be designed and utilized as stabilized pulses. Stabilized pulses are pulses having stable inverse filters, and have previously only been established for asymmetric functions. The systems and methods described herein can be used for super-resolution pulse-echo imaging, for example super-resolution ultrasound imaging. | 03-31-2016 |
20160068810 | Human Extensively Self-Renewing Erythroblasts (ESRE) - The present invention provides a human cell population that can self-renew extensively and yet retain the capacity to differentiate into red blood cells (RBCs). These cells are referred to as extensively self-renewing erythroblasts (ESREs). The cells of the invention serve among other things as a renewable source of transfusable RBCs. | 03-10-2016 |
20160061723 | FOCUSED BEAM SCATTEROMETRY APPARATUS AND METHOD - The capacity to measure nanoscale features rapidly and accurately is of central importance for the monitoring of manufacturing processes in the production of computer integrated circuits. It is known that far-field scattered light requires a priori sample information in order to reconstruct nanoscale information such as is required in semiconductor metrology. Parameters of interest include, for example, trench depth, duty cycle, wall angle and oxide layer thickness. We describe a scatterometry apparatus and method that uses unconventional polarization states in the pupil of a high NA objective lens, and refer to this as focused beam scatterometry, in which the illumination consists of a focused field with a suitably tailored, spatially-varying polarization distribution. We describe how four or more parameters can be measured and distinguished with an accuracy consistent with the needs laid out in the semiconductor roadmap. | 03-03-2016 |
20160058741 | Thiadiazolidinone Derivatives - The present invention relates to compounds of the formulae herein, their acceptable salts, solvates, hydrates and polymorphs thereof. The compounds of this invention are useful in treatment of disease, particularly leukemia. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating disease, disorders, or symptoms thereof in a subject. | 03-03-2016 |
20160045506 | USE OF INHIBITORS OF BINDING BETWEEN A PAR-1 RECEPTOR AND ITS LIGANDS FOR THE TREATMENT OF GLIOMA - The present invention relates to a method of treating glioma in a subject. The method comprises selecting a subject having a glioma, providing an inhibitor of binding between a PAR-1 receptor and a ligand of the PAR-1 receptor, and administering the inhibitor to the selected subject under conditions effective to treat the glioma and/or prevent spread of tumor cells. Methods for inhibiting proliferation of glioma cells and/or precursors thereof and a method of screening for compounds suitable for treating glioma in subjects are also disclosed. | 02-18-2016 |
20160038419 | COMPOSITION AND METHODS FOR THE TREATMENT OF PERIPHERAL NERVE INJURY - Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery. | 02-11-2016 |
20160034638 | System and Method for Detecting Population Variation from Nucleic Acid Sequencing Data - The present invention relates to a method of identifying genetic variants within a population of sequences. The method includes the steps of aligning a set of sequence data reads to reference sequences, dividing reference sequences into multiple tracks of overlapping regions of analysis (ROAs), partitioning each read into a ROA, identifying a plurality of sequence patterns in the reads, setting a sequence pattern frequency threshold value, eliminating any sequence pattern that has a value below the frequency threshold value forming a plurality of dictionaries from the sequence patterns having a value above the frequency threshold value, and cross-validating sequence patterns via partial sequence assembly. The method may optionally include amending the reference sequences used in iterative re-alignment of sequence data. | 02-04-2016 |
20160025956 | PARAXIAL CLOAK DESIGN AND DEVICE - A paraxial cloaking device provides a cloaking volume in which an item can be hid from view. A cloaking device includes an optical input receiving light rays and an optical output from which a continuous range of directions of the received light rays exit the paraxial cloaking device. The cloaking volume being disposed between the optical input and the optical output. For received light rays having incoming directions non-parallel to the reference optical axis up to a first angle, each of the received light rays exits the cloaking device substantially aligned with the respective received light ray and does not pass through the cloaking volume. The paraxial cloaking device has a unity magnification factor. In some instances, the paraxial cloaking device includes a phase matching element. | 01-28-2016 |
20160025745 | METHODS OF DIAGNOSING AND TREATING FIBROSIS - The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibrosis or a fibrotic condition are also disclosed. | 01-28-2016 |
20160024664 | METHODS FOR PRODUCING HYDROGEN USING NANOPARTICLE-CATALYST MIXTURES - Methods for producing hydrogen using nanoparticles, a catalyst, and a source of electrons, such as bacteria and their nutrient source in a biological system, are carried out in an aqueous medium. The nanoparticles may be doped with a plurality of isovalent and/or non-isovalent dopants. | 01-28-2016 |
20160024163 | MODULATION OF ANGIOGENESIS AND RELATED CONDITIONS USING INHIBITORS OF G-PROTEIN-COUPLED RECEPTOR KINASE INTERACTING PROTEIN-1 (GIT1) - The present invention is directed to methods and compositions comprising G-protein-coupled receptor kinase interacting protein-1 (GIT1) inhibitors that are suitable for inhibiting angiogenesis in a subject and treating related conditions. | 01-28-2016 |
20160022775 | TREATING LYSOSOMAL STORAGE DISEASE - Provided herein are compositions, kits and methods related to the treatment of one or more lysosomal storage diseases (LSDs) in a subject and methods of identifying agents that are useful for the treatment of one or more LSDs. The compositions, kits, and methods are based on the novel discovery that agents effective for treating LSD must have two characteristics: they must inhibit cell death and reduce suppression of cell division caused by toxic substances that accumulate in LSD. Exemplary agents include polypeptides (e.g., IGF-1, VEGF) and small molecules (e.g., chlorotrianisene, clofoctal, colforsin, and tulobuterol). | 01-28-2016 |
20160022681 | METHODS OF INCREASING LYMPHATIC TRANSPORT - Provided herein are methods of treating a lymphatic transport dysfunction or condition in a subject. Also provided are methods of preventing or reducing a flare in a subject with a lymphatic transport dysfunction or condition. Further provided are methods of monitoring lymphatic transport in a subject and methods of selecting a treatment protocol for a subject with a lymphatic transport dysfunction or condition. Further provided are methods of detecting a flare in a subject with a lymphatic transport dysfunction or condition. | 01-28-2016 |
20160000777 | METHODS OF USING HISTAMINE RECEPTOR AGONISTS AND ANTAGONISTS - This invention relates to a transdermal drug formulation that includes a pharmaceutically suitable carrier; an effective amount of a therapeutic agent; and a histamine type 4 receptor (“H4R”) agonist, as well as a transdermal vaccine formulation that includes a pharmaceutically suitable carrier; an effective amount of an antigen or antigen-encoding nucleic acid molecule present in the carrier, and optionally one or more adjuvants; and an H4R agonist. The present invention also relates to transdermal delivery device including such formulations and methods of administering such formulations. The present invention also relates to methods of enhancing epithelial barrier formation in a patient involving administering to the patient at a site of epithelial disruption an amount of a formulation that comprises an H4R antagonist. The present invention also relates to a method of inhibiting pathogen infection or local spread of infection in the epithelia using an H4R antagonist, an H1R antagonist, or a combination thereof. | 01-07-2016 |
20150374663 | Compositions and Methods for Controlled Localized Delivery of Bone Forming Therapeutic Agents - The present invention provides compositions and methods for providing controllable local delivery of a therapeutic agent to promote bone formation. In certain embodiments, the invention is used as a treatment for a subject with osteoporosis, bone cancer or bone fracture. The invention provides a therapeutic agent that is tethered to a polymer to form a therapeutic-tethered macromer, where the therapeutic agent is controllably released from the conjugate by degradation of the tether. In certain embodiments, the therapeutic agent is an inhibitor of GSK3β. In certain embodiments, the composition of the invention is specifically targeted to a site in need of bone formation. | 12-31-2015 |
20150374634 | Nanoparticles for Controlled Release of Anti-Biofilm Agents and Methods of Use - The present invention relates to compositions and methods to treat and/or prevent biofilms and biofilm related diseases. The invention comprises a nanoparticle carrier (NPC) and at least one therapeutic agent therein. The NPC binds within biofilm and to surfaces at risk for biofilm formation and accumulation while providing local, sustained, enhanced and controlled delivery of the therapeutic agent, when triggered for release. In one embodiment, the NPC comprises pH-responsive elements that allows for specific delivery of the therapeutic agent when the local environment dictates that the agent should be delivered precisely when it is most needed. | 12-31-2015 |
20150369823 | METHOD TO IDENTIFY PATIENTS THAT WILL LIKELY RESPOND TO ANTI-TNF THERAPY - The present invention identifies various methods for the identification of patients that suffer from an immune system disorder and are likely to benefit from anti-TNF therapy. Because of the significant cost of anti-TNF therapy and the high rate of ineffectiveness of anti-TNF therapy for treating immune disorders such as rheumatoid and psoriatic arthritis, the present invention will improve the delivery of effective therapies to patients in need of either anti-TNF therapy or alternative therapies. | 12-24-2015 |
20150352154 | INDUCED PLURIPOTENT CELL-DERIVED OLIGODENDROCYTE PROGENITOR CELLS FOR THE TREATMENT OF MYELIN DISORDERS - The present invention relates to preparations of induced pluripotent cell-derived oligodendrocyte progenitor cells, and methods of making, isolating, and using these preparations. | 12-10-2015 |
20150335674 | LDH INHIBITORS AS TREATMENT FOR FIBROSIS AND FIBROTIC-RELATED DISORDERS - One aspect of the disclosure relates to methods of treating a fibrotic condition in an individual. The methods include administering to an individual having a fibrotic condition an effective amount of a lactic dehydrogenase (LDH) inhibitor, wherein the fibrotic condition involves an internal organ or tissue, or ocular tissue, and said administering is effective to treat the fibrotic condition. Methods of administration and pharmaceutical compositions and systems for practicing such methods are also disclosed. | 11-26-2015 |
20150328339 | HUMAN GLIAL CHIMERIC MODEL FOR DRUG CANDIDATE ASSESSMENT IN HUMAN GLIOTROPHIC VIRAL INFECTIONS AND PROGRESSIVE MULTIFOCAL ENCEPHALOPATHY - The present invention is directed to a method of assessing in vivo human glial cell response to pathogenic infection that involves providing a non-human mammal either with at least 30% of its glial cells in its corpus callosum being human glial cells and/or with at least 5% of its glial cells its brain and brain stem white matter being human glial cells, subjecting the non-human mammal to pathogenic infection and assessing the in vivo human glial cell response to pathogenic infection. A method of identifying therapeutic agents for the pathogenic infection as well as forms of the non-human mammal having a pathogenic brain infection are also disclosed. | 11-19-2015 |
20150317915 | State Change Device And System For The Tactile Display of Information - A state change device and system for the tactile display of information is disclosed. The state change device uses a novel pin and driving coil arrangement combined with a bistable plate to create a high state and a low state where the pin either protrudes from a surface or is recessed below the surface. The state change device may be combined with other similar devices to create a Braille character and may be further combined to create a Braille reader where transient information is displayed on the Braille reader from a computing device or processor. The state change device makes possible low cost Braille displays that are reliable, compact, quickly refreshable and with more characters than current Braille displays, thus providing new life and opportunity for both the Braille alphabet and those that require the use of such. | 11-05-2015 |
20150299217 | ARTEMISININ DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTIMALARIAL AGENTS - Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections are provided. Methods are provided for the production of artemisinin derivatives via functionalization of positions C7 and C6a, and optionally, in conjunction with modifications at positions C10 and C9, via chemoenzymatic methods. Recombinant cytochrome P450 polypeptides are also provided for use in the methods. The artemisinin derivatives can be used for the treatment of malaria and other parasitic infections, alone or in combination with other antiparasitic drugs. | 10-22-2015 |
20150283214 | CHIMERIC FIBRONECTIN MATRIX MIMETICS AND USES THEREOF - The present invention is directed to recombinant fibronectin peptide mimetics and wound healing compositions containing the same. Other aspects of the present invention include wound healing dressings that comprise the wound healing composition of the present invention and a wound dressing material and methods of treating wounds using these compositions. | 10-08-2015 |
20150283205 | THY1 (CD90) AS A NOVEL THERAPY TO CONTROL ADIPOSE TISSUE ACCUMULATION - The present invention relates to methods of treating a condition involving excessive adipogenesis. This method relates to selecting a subject having a condition involving excessive adipogenesis and administering to the selected subject a composition comprising a Thy1 protein or polypeptide fragment thereof, or an agent that enhances Thy1 expression, under conditions effective to treat the condition. The present invention also relates to isolated nucleic acid molecules encoding a Thy1 protein or the fragment thereof and pharmaceutical formulations including such a protein or fragment thereof or an agent that enhances Thy1 expression and a pharmaceutically acceptable carrier. The present invention also relates to methods of inhibiting adipogenesis and/or decreasing adipocyte size, as well as methods of screening a candidate compound for its ability to influence adipogenesis. | 10-08-2015 |
20150283118 | SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE - Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. | 10-08-2015 |
20150273055 | METHODS AND COMPOSITIONS FOR EXPANDING HEMATOPOIETIC STEM AND PROGENITOR CELLS - Provided herein are methods for increasing the number of hematopoietic stem and progenitor cells (HSPCs) in vivo or in vitro. The methods can include the steps of selecting a subject in need of an increased number of HSPCs and administering to the subject an effective amount of an inhibitor of VEGF to increase the number of HSPCs in the subject. Optionally, the methods include the steps of contacting a population of HSPCs and supporting cells with an inhibitor of VEGF, and contacting the population of HSPCs and supporting cells with a parathyroid hormone (PTH) receptor agonist. Also provided is a method for increasing the number of hematopoietic stem and progenitor cells (HSPCs) in a subject including the steps of administering to the subject an inhibitor of VEGF, and administering to the subject a parathyroid hormone (PTH) receptor agonist. The method is optionally used in a subject or for a with decreased osteogenesis, including, for example, when the subject has a bone fracture or has osteoporosis. Compositions and kits for increasing the number of HSPCs comprising (i) one or more doses of an inhibitor of VEGF; and (ii) one or more doses of a PTH receptor agonist are also provided. | 10-01-2015 |
20150265629 | USE OF ELECTROPHILIC COMPOUNDS FOR INDUCING PLATELET PRODUCTION OR MAINTAINING PLATELET FUNCTION - The present invention is directed to a method of inducing platelet production that includes contacting a megakaryocyte with an electrophilic compound under conditions effective to induce platelet production by the contacting megakaryocyte. Methods of treating a patient for low platelet levels, increasing the circulating half-life of platelets, and improving the quality (activity) of platelets are also disclosed herein, which involve administering the electrophilic compound to a patient an effective amount to achieve the desired effect. Pharmaceutical compositions and therapeutic systems are also disclosed for carrying out these therapeutic treatments. | 09-24-2015 |
20150265344 | CATHETER WITH INTEGRATED TRANSSEPTAL PUNCTURE NEEDLE - A cardiac treatment system of the subject technology provides access across an interatrial septum of a patient. Such a treatment system can include a catheter having an ablation treatment device on an outer surface of a distal region thereof. A needle is provided at least partially within a lumen of the catheter. A control unit is operatively connected to the ablation treatment device for ablation of a portion of a septum by RF ablation. A distal end of a catheter is provided to the septum (e.g., at the fossa ovalis) of the patient while a distal tip of the needle is within the lumen and proximal to the distal end of the catheter. The distal tip of the needle punctures and crosses the septum, and a portion of the septum is ablated with an ablation treatment device aligned with the septum by guidance from the needle. | 09-24-2015 |
20150242217 | SYSTEM AND METHOD TO QUANTIFY DIGITAL DATA SHARING IN A MULTI-THREADED EXECUTION - A method to quantify a plurality of digital data sharing in a multi-threaded execution includes the steps of: providing at least one processor; providing a computer readable non-transitory storage medium including a computer readable multi-threaded executable code and a computer readable executable code to calculate a plurality of shared footprint values and an average shared footprint value; running the multi-threaded executable code on the at least one computer processor; running the computer readable executable code configured to calculate a plurality of shared footprint values and an average shared footprint value; calculating a plurality of shared footprint values by use of a linear-time process for a corresponding plurality of executable windows in time; and calculating and saving an average shared footprint value based on the plurality of shared footprint values to quantify by a metric the data sharing by the multi-threaded execution. A system to perform the method is also described. | 08-27-2015 |
20150238495 | Treatment or Prevention of Fungal Infections with PDK1 Inhibitors - Provided are methods of treating or preventing a fungal infection in a subject. The methods comprise identifying a subject with or at risk of developing a fungal infection and administering to the subject a therapeutically effective amount of an inhibitor or a fungal phosphoinositide-dependent kinase 1 (PDK-1) or a homolog thereof. Inhibition of the fungal PDK-1 or homolog thereof results in the treatment or prevention of a fungal infection in the subject. Also provided are compositions comprising an inhibitor of a fungal phosphoinositide-dependent kinase 1 (PDK-1) or a homolog thereof, and a pharmaceutically acceptable carrier. | 08-27-2015 |
20150238441 | Modulation of Branched Amino Acid Concentrations to Treat Metabolic Diseases - The plasma concentration of at least one branched chain amino acid in a mammal in need of such reduction is reduced by administering an agent that increases the plasma concentration of large neutral amino acids. The invention also includes related compositions and methods. These methods and compositions can be used to treat insulin resistance, type 2 diabetes and metabolic syndrome. | 08-27-2015 |
20150208915 | SYSTEM AND METHOD FOR OBSERVING AN OBJECT IN A BLOOD VESSEL - A method for creating a virtual 2D image of an object moving in a blood vessel includes the steps of: providing an imaging apparatus capable of acquiring 1D images. The imaging apparatus is communicatively coupled to a computer. Multiple 1D images of a substantially fixed footprint on a surface of an organ are acquired over a period of time. A virtual 2D image showing the object moving in the blood vessel is formed by combining by computer the multiple 1D images. The virtual 2D image can be displayed and/or saved to a non-volatile memory. A system to perform the method is also described. Another method for creating a virtual 1D image of an object moving in a blood vessel is also described. | 07-30-2015 |
20150206309 | SYSTEM AND METHOD FOR REAL-TIME IMAGE REGISTRATION - A method for image registration includes the steps of: providing a computer and an imager; acquiring and processing a reference image frame including a plurality of reference strips; acquiring and correcting a target frame by the steps of: acquiring one or more target frame strips of the target frame; comparing the one or more target frame strips in real-time to one or more corresponding strips of the reference frame based on a calculated registration of a specific target frame strip from a previous target frame; correcting a registration of the one or more target frame strips; repeating steps until a last strip of the target frame; repeating the steps of acquiring and correcting a target frame until a last target frame is acquired; and saving processed image based on a plurality of corrected target frames to a non-volatile memory. A system to perform the method is also described. | 07-23-2015 |
20150202215 | METHOD OF TREATING AND PREVENTING BRAIN IMPAIRMENT USING Na+-K+-2Cl- COTRANSPORTER ISOFORM 1 INHIBITORS - The disclosure relates to a method of treating and/or preventing brain impairment in a subject that has or is susceptible to ammonia neurotoxicity (increased plasma ammonia), by administering a Na-; —K+-2CI- cotransporter isoform 1 (“NKCC1”) inhibitor to the selected subject under conditions effective to treat and/or prevent brain impairment. The disclosure further relates to methods of maintaining the fundamental function of astrocytic potassium buffering and inhibiting accumulation of potassium star rounding astrocytes, both of which involve contacting astrocytes with a NKCC 1 inhibitor. | 07-23-2015 |
20150191003 | METALLIC NANO-TIP APPARATUS, METHODS, AND APPLICATIONS - Methods for template-stripping a single metallic nano-tip structure from a template containing a plurality of ready-to-be-template-stripped inverted metallic nano-tip structures include attaching the metallic nano-tip structure to a wire handle or a cantilever. A metallic nano-tip assembly includes a single metallic nano-tip structure attached to a handle or mounted on a cantilever structure. The metallic nano-tip assembly may be conductive. | 07-09-2015 |
20150157204 | Light Source Modulation for a Scanning Microscope - Systems, method, and non-transitory computer readable medium for imaging an object. The system includes a scanner. The scanner positions a spot of light from a light source on the object along a scanning path. The scanning path includes a plurality of scan lines. The spot moves along the scanning path at a scanning velocity. The scanning velocity is not constant. The intensity of the spot of light is modulated as a function of the scanning velocity. The system includes a detector that is arranged to output data associated with positions along the scanning path. The system includes one or more processors that perform calculations. Pixels are calculated based on the output data. The image is constructed of the object based on the pixels. | 06-11-2015 |
20150156365 | Image Based Correction of Distortion from a Scanner - System, method, and non-transitory computer readable medium encoded with instructions for imaging an object. Dividing raw data into forward scan data and backward scan data. Reversing the order of the backward scan data to produce inverted backward scan data. Determining an offset value that is associated with a maximum value of a first function based on the forward scan data and the inverted backward scan data. The forward scan data is shifted by the offset value relative to the inverted backward scan data. Producing a first image of the object that comprises the forward scan data interlaced with the inverted backward scan data. The forward scan data is shifted by the offset value relative to the inverted backward scan data. | 06-04-2015 |
20150136226 | SUPER-HYDROPHOBIC SURFACES AND METHODS FOR PRODUCING SUPER-HYDROPHOBIC SURFACES - A metal or metal alloy including a region with hierarchical micro-scale and nano-scale structure shapes, the surface region is super-hydrophobic and has a spectral reflectance of less than 30% for at least some wavelengths of electromagnetic radiation in the range of 0.1 μm to 10 μm. Methods for forming the hierarchical micro-scale and nano-scale structure shapes on the metal or metal alloy are also described. | 05-21-2015 |
20150132297 | SURVIVAL PREDICTOR FOR DIFFUSE LARGE B CELL LYMPHOMA - The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients. | 05-14-2015 |
20150125515 | NOVEL SP-B & SP-C PEPTIDES, SYNTHETIC LUNG SURFACTANTS, AND USE THEREOF - The present invention relates to synthetic lung surfactant compositions that include a novel surface active peptide and a phospholipid, including phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, naturally occurring phospholipids, or a combination thereof. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue and to deliver therapeutic agents are also disclosed. | 05-07-2015 |
20150104087 | Automated Fundus Image Field Detection and Quality Assessment - A method, system, and computer readable medium which automatically determine the side, field and a level of image quality of fundus images of the retina of a human eye is disclosed. The disclosure combines image processing, computer vision and pattern recognition techniques in a unique way to provide a robust process to identify and grade the quality of fundus images with application to improve efficiency and reduce errors in clinical or diagnostic retinal imaging workflows. | 04-16-2015 |
20150103356 | Interferometer, System, and Method of Use - A compact, balanced, up to three degrees of freedom measuring interferometer which enables fiber delivery of an optical source without periodic nonlinearity, an interferometer system, and method for using an interferometer to measure up to three degrees of freedom is disclosed. | 04-16-2015 |
20150083893 | Method And Device For Preserving and Imaging Specimens While Retaining Information On The Spatial Orientation Of Specimens With Respect To Reference Objects - An object, such as a tumor from a breast lumpectomy, is placed into an object positioning device that can hold the object without deforming it. Such a device can include a container with a deformable foam, gel, or other material. The object positioning device is moved into an imaging device. Images of the object within the object positioning device are acquired by the imaging device. The acquired images are stored, processed, or output on a display device. Information about the spatial orientation of the object with respect to a reference object is preserved. | 03-26-2015 |
20150077759 | Compact, Slope Sensitive Optical Probe - An optical probe system has a light source fiber-delivered and the detector fiber-coupled for analyzing carrier fringes using a line sensor to measure displacement and tilt. Simultaneous surface metrology to measure both the front and back surface of the same optic, is enabled provided the two surfaces are substantially parallel to within the measurement range. Alternatively, the front surface can be measured and then subsequently the back surface. | 03-19-2015 |
20150077706 | REAL-TIME OPTICAL AND DIGITAL IMAGE STABILIZATION FOR ADAPTIVE OPTICS SCANNING OPHTHALMOSCOPY - A real-time ophthalmoscope system for imaging an eye includes a wide field scanning light ophthalmoscope (SLO) configured for wide field imaging of the eye. The system also includes a small field SLO configured for high resolution imaging of the eye. A 2D tracking minor electrically coupled to a computer, and a 2D steering minor electrically coupled to the computer, are both disposed in an optical path between the small field SLO and the eye. The system is configured to acquire a plurality of small field images at a plurality of locations on the eye as defined by the 2D steering minor, each of the small field images is stabilized for a motion of the eye by the 2D tracking minor. A method for imaging of the eye is also described. | 03-19-2015 |
20150073240 | Implantable Real-Time Oximeter To Determine Potential Strokes And Post-Traumatic Brain-Injury Complications - A first embodiment of an oximetry probe is attached around a blood vessel near the site of a likely stroke. That will be useful to monitor large and medium size cerebral arteries. Another type of pulse oximeter can be passed within cerebral blood vessels to monitor the oxygenation status of the surrounding cerebral tissues. In that version, the emitter and detector are coplanar and contained in a small area, e.g., 50-12 μm. | 03-12-2015 |
20150070655 | APPARATUS AND METHOD FOR AUTOMATIC ALIGNMENT IN AN OPTICAL SYSTEM AND APPLICATIONS - Methods and apparatus for automatically aligning a confocal aperture utilize a confocal imaging system and a computer controlled optimization algorithm such as the Nelder-Mead algorithm for imaging an in-vivo eye having chromatic aberration. When using a confocal aperture of 3.4 Airy disks in diameter, images were obtained using retinal radiant exposures of less than 2.44 J/cm | 03-12-2015 |
20150056171 | Methods of Predicting Clinical Outcome of Chronic Lymphocytic Leukemia - Provided are methods of predicting the outcome of a chronic lymphocytic leukemia (CLL) in a subject. The methods comprise performing a polymerase chain reaction assay for an IGH locus on a nucleic acid from a biological sample from a subject with CLL, wherein the PCR assay amplifies a non-coding region of the IGH locus, sequencing a product from the PCR assay, and determining a level of mutation in the non-coding region of the IGH locus. An increased level of mutation in the non-coding region as compared to a control indicates a positive outcome for the subject with CLL. A decreased level or no mutation in the non-coding region as compared to a control indicates a poor outcome for the subject with CLL. | 02-26-2015 |
20150042954 | System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics - Techniques are illustrated herein for 1- and 2-photon fluorescence lifetime imaging in the living retina, using adaptive optics to correct aberrations and achieve cellular level resolution. 1-photon fluorescence embodiments may include the use of a confocal pinhole to provide axial sectiontin. 2-photon embodiments allow for inherent axial sectioning without having to block out-of-focus light. | 02-12-2015 |
20150037815 | METHOD FOR THE TOPOGRAPHICALLY-SELECTIVE PASSIVATION OF MICRO- AND NANOSCALE DEVICES - Disclosed is a method of preparing a biosensor that involves providing a substrate including a surface having a topographical pattern formed at one or more sites on or in the surface, coating the substrate with a solution including hydrogel particles, wherein the hydrogel particles self-assemble on the surface to mask the surface except at the one or more sites, and binding one or more capture molecules to the one or more sites to form the biosensor. Systems that include the biosensor, as well as methods of using the biosensor, are also disclosed. | 02-05-2015 |
20150037301 | RECOMBINANT FACTOR VIII HAVING ENHANCED STABILITY FOLLOWING MUTATION AT THE A1-C2 DOMAIN INTERFACE - The invention relates to a recombinant factor VIII that includes one or more mutations at an interface of A1 and C2 domains of recombinant factor VIII. The one or more mutations include substitution of one or more amino acid residues with either a cysteine or an amino acid residue having a higher hydrophobicity. This results in enhanced stability of factor VIII. Methods for making the recombinant factor VIII, pharmaceutical compositions containing the recombinant factor VIII, and use of the recombinant factor VIII for treating hemophilia A are also disclosed. | 02-05-2015 |
20150031991 | Depth Advancement Marker Needle For Image Guided Procedures - Many image guided needle procedures use ultrasound, computed tomography (CT) magnetic resonance imaging (MRI) or other imaging systems. In such procedures, there is currently a preference for long axis injections and related procedures where the long axis of the needle is parallel to the plane of the two dimensional images created by the imaging system. This is due to the fact that long axis imaging of a needle provides good visual indication of depth of penetration of the needle, whereas short axis imaging shows only a dot or small circle, which is the cross section of the needle and provides no depth of penetration information. Many procedures, however, benefit from, or require the use of, short axis imaging. | 01-29-2015 |
20150018380 | Methods of Screening for Activation Deaminase Inhibitors Through Nuclear Import Inhibitors - The present invention provides methods for obtaining specific and non-toxic inhibitors of AID nuclear import. The methods comprise a primary screen and a counter screen to identify a pool of AID specific nuclear import inhibitors that do not have off-target of toxic effects. AID specific nuclear import inhibitors identified by the screens of the invention prevent nuclear entry, limit the access of AID to genomic DNA, and inhibit AID mutagenic activity. Preparations, including pharmaceutical preparations, comprising specific nuclear import inhibitors, used for example, to inhibit cancer progression, are also encompassed in the invention. | 01-15-2015 |
20150010643 | METHODS, PHARMACEUTICAL COMPOSITIONS, THERAPEUTIC SYSTEMS, AND COMPOUNDS FOR TREATING B CELL MALIGNANCIES - This invention relates to a method of treating B cell malignancies, which involves administering to a subject a compound having a structure of formula (I) to cause cell death of a B cell malignancy, thereby treating the B cell malignancy in the subject. Also disclosed are a method of causing cell death of malignant B cells, pharmaceutical compositions and therapeutic systems comprising a compound having a structure of formula (I), and a compound having a structure of formula (I). | 01-08-2015 |
20140378678 | Compositions and Methods for Recombinant Synthesis of High Molecular Weight Hyaluronic Acid - Provided is a novel hyaluronan synthase (HAS2), isolated nucleic acids encoding it, and expression vectors which express the novel HAS2. Also provided are cell cultures which contain cells which harbor the expression vectors, methods of using the cell cultures to produce high molecular weight hyaluronic acid, and cell culture media that contains the high molecular weight hyaluronic acid. | 12-25-2014 |
20140370531 | METHOD OF DIAGNOSING MILD TRAUMATIC BRAIN INJURY - The present invention relates to a method of determining whether a subject has suffered a mild traumatic brain injury. The method comprises selecting a subject exposed to a head trauma and determining an apoA-1 level in a body fluid sample obtained from the selected subject, wherein a decreased apoA-1 level in the body fluid sample indicates that the subject has suffered a mild traumatic brain injury. The invention also relates to a kit for determining whether a subject has suffered a mild traumatic brain injury. | 12-18-2014 |
20140362341 | SYSTEM AND METHOD FOR DESIGNING WAVEFRONT-GUIDED OPHTHALMIC LENSES - The design of a corrective lens combines the measured aberration with decentration and rotation of the lens to design customized optical surface profiles to reliably achieve vision correction. | 12-11-2014 |
20140316267 | NON-INVASIVE ASSESSMENT OF LIVER FAT BY CRAWLING WAVE DISPERSION WITH EMPHASIS ON ATTENUATION - Using a modified ultrasound device, crawling waves are applied to the liver over a range of shear wave frequencies. Dispersion measurements are obtained that reflect tissue viscosity and these correlate with the degree of steatosis. A device for the process has an actuator on either side of the ultrasound transducer to apply shear waves, which interfere to produce the crawling waves. | 10-23-2014 |
20140309992 | METHOD FOR DETECTING, IDENTIFYING, AND ENHANCING FORMANT FREQUENCIES IN VOICED SPEECH - Formant frequencies in a voiced speech signal are detected by filtering the speech signal into multiple frequency channels, determining whether each of the frequency channels meets an energy criterion, and determining minima in envelope fluctuations. The identified formant frequencies can then be enhanced by identifying and amplifying the harmonic of the fundamental frequency (F0) closest to the formant frequency. | 10-16-2014 |
20140303476 | Photoacoustic Imaging Using A Versatile Acoustic Lens - To image various soft tissues in the body using pulsed laser optical excitation delivered through a multi-mode optical fiber to create photoacoustic impulses, and then image the generated photoacoustic impulses with an acoustic detector array, a probe includes either a mirror and an acoustic lens or a special acoustic lens of variable focal length and magnification that can operate in a liquid environment that is aberration-corrected to a sufficient degree that high resolution images can be obtained with lateral as well as depth resolution. | 10-09-2014 |
20140296154 | METHOD OF PREVENTING DEVELOPMENT OF PSORIATIC LESIONS - The present invention relates to a method of inhibiting onset of or preventing development of a psoriatic lesion in a patient having psoriasis. The method comprises administering to a patient having psoriasis an effective amount of an agent that inhibits NF-κB activity under conditions effective to inhibit onset of or prevent development of psoriatic lesions. Another aspect of the invention relates to a method of treating an early stage psoriatic lesion on a patient by contacting the early stage psoriatic lesion of a patient with an effective amount of an agent that inhibits NF-κB activity, whereby said contacting inhibits development of the early stage psoriatic lesion. Both transgenic and nontransgenic approaches are contemplated. | 10-02-2014 |
20140285813 | WAVEFRONT SENSING APPARATUS, METHOD AND APPLICATIONS - A wavefront sensing technique using Polarization Rotation INTerferometry (PRINT) provides a self-referencing, high-resolution, direct measurement of the spatially dependent phase profile of a given optical beam. A self-referencing technique is used to create a reference beam in the orthogonal polarization and a polarization measurement to measure the spatial-dependent polarization parameters to directly determine the absolute phase profile of the beam under test. A high-resolution direct measurement of the spatially-resolved phase profile of one or more optical beams is realized. | 09-25-2014 |
20140277365 | ULTRASOUND-GUIDED ENDOGRAFT SYSTEM - A stent delivery system can facilitate positioning of a stent within a first vessel. The system can include an elongate member, an expandable stent coupled to the elongate member, and an imaging mechanism, such as an ultrasonic probe. The imaging mechanism can be positioned distal or proximal relative to the stent or adjacent to an aperture in the stent, such that the imaging mechanism can facilitate positioning of the stent within the first vessel such that flow into an orifice of a second vessel is not blocked by the stent. | 09-18-2014 |
20140276347 | INTRAOSSEOUS SHUNTS - An intraosseus shunt can comprise a shunt body and a valve. The shunt body can be configured for insertion into bone and can have a fluid inlet, a fluid outlet, and a flow passage extending within the shunt body between the fluid inlet and the fluid outlet. The flow passage, the fluid inlet, and the fluid outlet can be configured for cerebrospinal fluid flow therethrough to cancellous bone. The valve can be attached to the shunt body and configured to control flow through the flow passage. A method of shunting biological fluid away from a hyper-pressurized biological cavity to a bone can comprise (i) creating a passage through cortical bone to provide access to cancellous bone, and (ii) positioning the shunt into the passage. The valve can control communication between the biological cavity and the cancellous bone. | 09-18-2014 |
20140271656 | OPTIMIZED ANTIGENS OF PNEUMOCYSTIS AND USE THEREOF - Immunologically active agents are described, including isolated | 09-18-2014 |
20140257041 | PERINEAL RETRACTOR - An apparatus for perineal retraction during a prostatectomy includes a handle portion with a first end, a second end and a curvilinear segment between the first and second end. The second end faces in a direction toward the first end. The apparatus also includes a head portion including a first surface on one side of the head portion and a second surface on an opposite side of the head portion, the second surface being connected to or engageable with the second end of the handle. Use of the apparatus for perineal retraction during prostatectomy is also described. | 09-11-2014 |
20140256051 | DECARBOXYLATION DOSIMETRY - Methods and apparatuses of the present disclosure provide accurate and precise radiation dosimetry based on decarboxylation of a reactant upon exposure to ionizing radiation. The decarboxylation reaction yields carbon dioxide and stable end products, which can be detected and measured, and correlated to determine an amount of radiation exposure. The reactants include carboxyl acids, such as amino acids and others occurring naturally in mammals. The dosimetry may be performed in real-time or retrospectively by assaying a sample of tissue from a patient. Also disclosed is a device which detects and measures radiation dosages based on decarboxylation of a reactant contained therein. | 09-11-2014 |
20140234960 | METHODS AND COMPOSITIONS FOR MESENCHYMAL STEM CELL PROLIFERATION - Provided is a method for increasing proliferation of mesenchymal stem cells. The method entails contacting the cells with 6-bromoindirubin-3′-oxime (BIO). This results in robust proliferation and “sternness” in a dose-dependent fashion, as indicated by the gene expression of two stem cell genes: Sox2 and Nanog. | 08-21-2014 |
20140234322 | THROMBOPOIETIN MIMETICS FOR THE TREATMENT OF RADIATION OR CHEMICAL INDUCED BONE MARROW INJURY - Disclosed are transgenic non-human mammals, which useful for the screening of thrombopoietin mimetics, thrombopoietin receptor agonists, or thrombopoietin receptor antagonists active on the human thrombopoietin receptor. The transgenic non-human mammal has a genome that comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a humanized thrombopoietin receptor wherein said transgenic non-human mammal has a baseline blood platelet count corresponding to a physiological blood platelet count of a matched non-transgenic non-human mammal. The chimeric thrombopoietin receptor comprises either the transmembrane domain of a human thrombopoietin receptor or both the extracellular and transmembrane domains of a human thrombopoietin receptor operably coupled to a cytoplasmic domain of a non-human thrombopoietin receptor. | 08-21-2014 |
20140200469 | NON-CONTACT ELECTROCARDIOGRAM SYSTEM - A non-contact electrocardiogram (ECG) sensor having an ECG electrode and guard electrode coupled to an electronic circuit that actively gain-corrects the electrocardiogram signal based on fringe capacitance signal and filters the gain-corrected signal based on a static charge reference signal. The compensation system first makes a gain correction for the preamplifier to address ECG electrode-to-subject motion and then removes any additive static common mode interference from motion-induced static charge generation. | 07-17-2014 |
20140194348 | METHOD OF INHIBITING PAPILLOMAVIRUS PROLIFERATION AND TREATING PAPILLOMAVIRUS INFECTION - Methods for inhibiting virus proliferation and treating an individual having a papillomavirus infection preventing viral infection are disclosed. The methods include the steps of providing a composition comprising a plurality of papillomavirus virus-like particles or capsomeres and contacting papillomavirus-infected tissue of an individual with the composition under conditions effective to inhibit papillomavirus proliferation or treat the papillomavirus infection in the individual. | 07-10-2014 |
20140186376 | Compositions and Methods for Inhibiting CCL3 - The present invention relates to the discovery that CCL3, through at least one of its receptors CCR1 and CCR5, plays a role in the pathologies associated with myeloid neoplasms. In various embodiments, the pathologies associated with myeloid neoplasms treatable by the compositions and methods of the invention described herein include, but are not limited to, at least one of osteoclast/osteoblast imbalance, inhibition of osteoblast function, bone loss, disregulation of the hematopoietic stem cell microenvironment, abnormal hematopoietic recovery, pancytopenia, anemia, thrombocytopenia, neutropenia, bicytopenia, and erythrocytopenia. Interfering with the interaction between CCL3 and its receptors, by targeting at least one of CCL3, CCR1, CCR5, diminishes the effects of pathologies associated with myeloid neoplasms. In various embodiments, the myeloid neoplasm is a myeloproliferative disorder, acute myeloid leukemia (AML), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMML), or myelodysplastic syndrome (MDS). | 07-03-2014 |
20140186300 | Targeted pre-mRNA/mRNA modification and gene regulation - Methods for affecting mRNA expression or translation through the modification of pre-mRNA or mRNA transcripts are described. In one embodiment of the methods of the present invention, the branch point adenosine of a pre-mRNA transcript is 2′-0-methylated to block splicing and subsequent expression of the protein encoded by the transcript. In another embodiment, a uridine residue in a nonsense stop codon may be modified to pseudouridine, causing the translation machinery to read through the nonsense stop codon and translate a full length protein. | 07-03-2014 |
20140186271 | REDUCING DENTAL CARIES - Provided are methods of reducing the occurrence of dental caries in a subject. The methods comprise selecting a subject with or at risk of developing dental caries and contacting the oral cavity of the subject with a therapeutically effective amount of an HMG-CoA reductase inhibitor. Also provided are oral treatment forms comprising a statin or derivative thereof. | 07-03-2014 |
20140180091 | Shear-Modulus Estimation by Application of Spatially Modulated Impulse Acoustic Radiation Force Approximation - A method for determining a shear modulus of an elastic material with a known density value is provided. In this method, a spatially modulated acoustic radiation force is used to initially generate a disturbance of known spatial frequency or wavelength. The propagation of this initial displacement as a shear wave is measured using ultrasound tracking methods. A temporal frequency is determined based on the shear wave. The shear modulus of the elastic material at the point of excitation may be calculated using the values of the spatial wavelength, material density, and temporal frequency. | 06-26-2014 |
20140163896 | HIV INCIDENCE ASSAYS WITH HIGH SENSITIVITY AND SPECIFICITY - The invention provides methods for manipulating the distribution of HIV gene sequences from a subject infected with HIV to classify whether the subject has been infected for more or less than a year. The Methods are useful, for example, in determining whether prophylactic interventions such as vaccines or drug candidates are slowing the rate of transmission in a population. | 06-12-2014 |
20140161852 | NANOPARTICLE DENTAL COMPOSITION AND METHOD OF MAKING - Disclosed are compositions and methods for reducing dentin hypersensitivity. Also disclosed are compositions containing calcium fluoride nanoparticles. | 06-12-2014 |
20140155471 | TREATING NEUROLOGICAL DISEASE OR INJURY WITH A DYNAMIN-RELATED PROTEIN 1 (DRP1) ENCODING NUCLEIC ACID - Provided herein are methods of treating a neurological disease or injury in a subject comprising administering to the subject a recombinant adeno-associated virus (rAAV) vector comprising a DRP1-encoding nucleic acid, wherein the DRP1 encoded by the nucleic acid comprises a mutation compared to wild-type DRP1. | 06-05-2014 |
20140154526 | FEMTOSECOND LASER PULSE SURFACE STRUCTURING METHODS AND MATERIALS RESULTING THEREFROM - Embodiments of the present invention are generally directed to materials processing methods using femtosecond duration laser pulses, and to the altered materials obtained by such methods. The resulting nanostructured (with or without macro- and micro-structuring) materials have a variety of applications, including, for example, aesthetic applications for jewelry or ornamentation; biomedical applications related to biocompatibility; catalysis applications; and modification of, for example, the optical and hydrophilic properties of materials including selective coloring. | 06-05-2014 |
20140148697 | NON-INVASIVE ASSESSMENT OF LIVER FAT BY CRAWLING WAVE DISPERSION - Using a modified ultrasound device, crawling waves are applied to the liver over a range of shear wave frequencies. Dispersion measurements are obtained that reflect tissue viscosity and these correlate with the degree of steatosis. A device for the process has an actuator on either side of the ultrasound transducer to apply shear waves, which interfere to produce the crawling waves. | 05-29-2014 |
20140128800 | PHOTOACTIVATABLE RECEPTORS AND THEIR USES - Provided herein is a chimeric photoactivatable polypeptide comprising an opsin membrane receptor, wherein an intracellular domain of the opsin membrane receptor is replaced with a corresponding intracellular domain of a chemokine receptor, a sphingosine-1-phosphate receptor or an ATP receptor and uses thereof. Further provided are methods of treating cancer, injury of the nervous system, autoimmune disease, and graft rejection comprising administering to the subject a cell that expresses the chimeric photoactivatable polypeptide and exposing the cell to a visible light source. | 05-08-2014 |
20140127232 | DETECTING, PREVENTING, AND TREATING BRONCHOPULMONARY DYSPLASIA - Provided herein are methods for preventing or treating bronchopulmonary dysplasia (BPD) in a subject. The methods comprise identifying connective tissue mast cells (CTMCs) in a subject and administering an agent that blocks an activity of blocks an increase in a level of or reduces a level of the CTMCs in the subject. Also provided are methods of identifying a subject with or at risk for developing BPD. Also provided are methods for determining the effectiveness of a treatment regime for BPD in a subject. | 05-08-2014 |
20140120071 | RECOMBINANT FACTOR VIII HAVING ENHANCED STABILITY FOLLOWING MUTATION AT THE A1-C2 DOMAIN INTERFACE - The invention relates to a recombinant factor VIII that includes one or more mutations at an interface of A1 and C2 domains of recombinant factor VIII. The one or more mutations include substitution of one or more amino acid residues with either a cysteine or an amino acid residue having a higher hydrophobicity. This results in enhanced stability of factor VIII. Methods for making the recombinant factor VIII, pharmaceutical compositions containing the recombinant factor VIII, and use of the recombinant factor VIII for treating hemophilia A are also disclosed. | 05-01-2014 |
20140113978 | MULTIFOCAL HEPATOCELLULAR CARCINOMA MICRORNA EXPRESSION PATTERNS AND USES THEREOF - The present invention is directed to methods and products for defining a biomarker of disease phenotype. The present invention further relates to methods and kits for determining a subject's risk of developing recurrent hepatocellular carcinoma based on a defined microRNA biomarker that reliably distinguishes hepatocellular carcinoma disease recurrence from non-recurrence. The invention also relates to methods of treating a patient having heptocellular carcinoma based on their risk of developing hepatocellular carcinoma disease recurrence. | 04-24-2014 |
20140107632 | METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES - A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss. | 04-17-2014 |
20140107523 | MODEL FOR TRAUMATIC BRAIN INJURY - Models for simulating traumatic brain injury provide analogues for studying similar occurrences in humans. Such models may include inserting a subject into a sheath. While in the sheath, the subject may be placed on a pad beneath an impactor. The head of the subject may be impacted by the impactor, whereby the head of the subject moves into the pad. Methods may further include attaching a helmet to the head of the subject. An arm of an impact device may be connected to a handle of the helmet, such that the head of the subject is restrained relative to the impact device. While advancing the impactor, the arm may be disconnected from the handle, such that the head of the subject becomes unrestrained relative to the impact device and moves into the pad in response to the impacting. | 04-17-2014 |
20140105908 | METHODS FOR TREATING PROSTATE CANCER - Disclosed herein are methods and compositions for reducing the recurrence of prostate cancer and for treating prostate cancer. | 04-17-2014 |
20140104572 | TUNABLE ACHROMATIZING OPTICAL APPARATUS, METHODS, AND APPLICATIONS - A tunable, achromatizing optical system for use with a broadband imaging modality system for imaging objects having a range of longitudinal chromatic aberration (LCA) values. The optical system includes an achromatizing component and a parfocal component, for example, a zoom system. A method for tuning the wavefront curvature of different chromatic components of objects having a range of longitudinal chromatic aberration (LCA) values when imaged by a broadband imaging modality system includes the steps of providing a broadband imaging modality system having an entrance pupil, for imaging an object having longitudinal chromatic aberration; providing a tunable, achromatizing optical system; and varying the focal length of the parfocal component while maintaining a conjugate relationship between the achromatizing component and the entrance pupil of the broadband imaging modality system. | 04-17-2014 |
20140088422 | ROBOTIC LOCALIZING AID FOR HIGH INTENSITY FOCUSED ULTRASOUND DELIVERY - A holding structure holds a biopsy needle and a HIFU transducer to allow smooth and accurate delivery of the HIFU beam at the interface of the liver, where bleeding will occur. This manipulator structure performs the biopsy and HIFU through the percutaneous approach. In addition, the procedure is imaged by an imaging ultrasound probe. This imaging ultrasound probe can track the needle entry site even when needle has been removed. The HIFU transducer fires a short pulse of HIFU in the needle tract to cause coagulation and stop bleeding. | 03-27-2014 |
20140081072 | Deep Brain Magnetic Stimulator - A deep brain magnetic stimulator is disclosed that is placed within a vessel of the body to provide targeted location specific application of a magnetic field within the brain. The deep brain magnetic stimulator has a stimulation coil affixed to an expandable device core where the device core has a lumen to allow the passage of blood. A source of electrical energy is provided as well as related control circuitry to govern the activation of the stimulation coil and also govern such parameters as magnetic field strength, duration, waveform, and the like. | 03-20-2014 |
20140080795 | NRF2 Deficiency Influences Susceptibility to Steroid Resistance via HDAC2 Reduction - Methods for the treatment or prevention of diseases which are caused by the decreased concentrations of histone deacetylase 2 (HDAC2) in cells are described. The diseases which may be treated by the methods of the invention include chronic obstructive pulmonary disease (COPD) and asthma, including steroid resistant COPD and asthma. The invention provides methods for treating or preventing of diseases caused by the degradation of HDAC2 by providing to the subject in need of treatment or prevention a molecular compound capable of preventing the degradation of HDAC2. Such molecular compounds include Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activators. Methods are further provided for the treatment and prevention of COPD and asthma by providing to a subject in need of such treatment and prevention a nucleic acid which causes expression of HDAC2 in lung cells and/or a nucleic acid which causes expression of Nrf2 in lung cells. | 03-20-2014 |
20140066376 | PROTECTING AND REPAIRING CARTILAGE AND MUSCULOSKELETAL SOFT TISSUES - Provided herein are compositions and methods related to promoting protection or repair of articular cartilage and/or musculoskeletal soft tissue by contacting the cartilage, tissues or cellular components thereof with a parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) receptor agonist or releasing factor. | 03-06-2014 |
20140057864 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING A RETROVIRUS INFECTION - The invention provides methods, compositions, and kits featuring a ribonucleoside chain terminator for use in preventing or inhibiting a retrovirus infection. | 02-27-2014 |
20140056919 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY CONDITIONS - The present invention is directed to methods of treating an inflammatory condition in a patient. This method includes providing a therapeutic agent that is a vascular endothelial growth factor receptor-3 (VEGFR-3) agonist or a nucleic acid molecule encoding a VEGFR-3 agonist. The present invention is further directed to pharmaceutical compositions and therapeutic systems for treating an inflammatory condition. | 02-27-2014 |
20140056861 | RECOMBINANT FACTOR VIII HAVING INCREASED STABILITY - The present invention relates to a recombinant factor VIII that includes one or more mutations that result in enhanced stability of both factor VIII and factor VIIIa. Methods of making and using the recombinant factor VIII, and pharmaceutical compositions containing the same are also disclosed. The present invention further relates to an isolated nucleic acid molecule that encodes the recombinant factor VIII, as well as DNA expression systems and host cells containing the isolated nucleic acid molecule. | 02-27-2014 |
20140050778 | NUCLEIC ACID BINDING COMPOUNDS, METHODS OF MAKING, AND USE THEREOF - The present invention relates to oligomer compounds, including dimers and trimers, formed by a disulfide, sulfinyl thio, olefin or hydrocarbon bond, or a hydrazone exchange bond between two or more monomers. Methods of making the monomers and the oligomers is also disclosed. Use of the compounds for inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-1 RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules. | 02-20-2014 |
20140047572 | THROMBOPOIETIN MIMETICS FOR THE TREATMENT OF RADIATION OR CHEMICAL INDUCED BONE MARROW INJURY - Disclosed are transgenic non-human mammals, which useful for the screening of thrombopoietin mimetics, thrombopoietin receptor agonists, or thrombopoietin receptor antagonists active on the human thrombopoietin receptor. The transgenic non-human mammal has a genome that comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a humanized thrombopoietin receptor wherein said transgenic non-human mammal has a baseline blood platelet count corresponding to a physiological blood platelet count of a matched non-transgenic non-human mammal. The chimeric thrombopoietin receptor comprises either the transmembrane domain of a human thrombopoietin receptor or both the extracellular and transmembrane domains of a human thrombopoietin receptor operably coupled to a cytoplasmic domain of a non-human thrombopoietin receptor. | 02-13-2014 |
20140044775 | SYNTHETIC LUNG SURFACTANT AND USE THEREOF - The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed. | 02-13-2014 |
20140038850 | METHODS AND SYSTEMS FOR EVALUATING AND PREDICTING THE REACTIVITY OF MONOOXYGENASE ENZYMES - Methods and systems for evaluating and predicting the reactivity of natural and engineered monooxygenase enzymes are provided. Methods are provided for acquiring a functional profile (fingerprint) of monooxygenases that encode information regarding the active site configuration of such monooxygenases. Methods are also provided for carrying out analysis of a monooxygenase fingerprint, to formulate predictions regarding the reactivity properties (e.g., substrate reactivity, chemo-, regio, and stereoselectivity properties) of the fingerprinted monooxygenases. | 02-06-2014 |
20140037044 | METHOD AND APPARATUS FOR CONE BEAM BREAST CT IMAGE-BASED COMPUTER-AIDED DETECTION AND DIAGNOSIS - Cone Beam Breast CT (CBBCT) is a three-dimensional breast imaging modality with high soft tissue contrast, high spatial resolution and no tissue overlap. CBBCT-based computer aided diagnosis (CBBCT-CAD) technology is a clinically useful tool for breast cancer detection and diagnosis that will help radiologists to make more efficient and accurate decisions. The CBBCT-CAD is able to: 1) use 3D algorithms for image artifact correction, mass and calcification detection and characterization, duct imaging and segmentation, vessel imaging and segmentation, and breast density measurement, 2) present composite information of the breast including mass and calcifications, duct structure, vascular structure and breast density to the radiologists to aid them in determining the probability of malignancy of a breast lesion. | 02-06-2014 |
20140032848 | Sharing Pattern-Based Directory Coherence for Multicore Scalability ("SPACE") - A method and directory system that recognizes and represents the subset of sharing patterns present in an application is provided. As used herein, the term sharing pattern refers to a group of processors accessing a single memory location in an application. The sharing pattern is decoupled from each cache line and held in a separate directory table. The sharing pattern of a cache block is the bit vector representing the processors that share the block. Multiple cache lines that have the same sharing pattern point to a common entry in the directory table. In addition, when the table capacity is exceeded, patterns that are similar to each other are dynamically collated into a single entry. | 01-30-2014 |
20140030285 | Altered OSPA of Borrelia Burgdorferi - Provided herein are OspA polypeptides from Lyme Disease-causing | 01-30-2014 |
20140027808 | LATERAL CARRIER INJECTION INFRARED LIGHT EMITTING DIODE STRUCTURE, METHOD AND APPLICATIONS - A Si-based light emitting diode structure and a method for fabricating the Si-based light emitting diode structure are each predicated upon a multilayer material layer that comprises alternating, interposed and laminated sub-layers of: (1) a group IV nanocrystal material; and (2) an erbium or neodymium doped dielectric material. The light emitting diode structure is preferably laterally actuated to provide both efficient photoluminescence and electroluminescence. The group IV nanocrystal material may comprise a silicon nanocrystal material and the doped dielectric material may comprise an erbium doped silicon oxide material. | 01-30-2014 |
20130344053 | Methods of Modifying Insulin Signaling Using Biliverdin Reductase (BVR) and BVR Derived Peptides - The present invention relates to a method of modulating insulin signaling in a cell. This method involves modifying the nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, in a cell, whereby a change in nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, modulates insulin signaling in the cell via biliverdin reductase interaction with one or both of insulin receptor kinase domain and insulin receptor substrate. Also disclosed are methods of treating a condition associated with insulin signaling and treating a patient for a condition associated with insulin-mediated glucose uptake. | 12-26-2013 |
20130337038 | CHIMERIC FIBRONECTIN MATRIX MIMETICS AND USES THEREOF - The present invention is directed to recombinant fibronectin peptide mimetics and wound healing compositions containing the same. Other aspects of the present invention include wound healing dressings that comprise the wound healing composition of the present invention and a wound dressing material and methods of treating wounds using these compositions. | 12-19-2013 |
20130331698 | SUPERRESOLUTION IMAGING OF SCATTERERS IN PULSE-ECHO IMAGING - In ultrasound B-scan imaging or other pulse-echo imaging, an inverse filter solution eliminates both the speckle phenomenon and the poor resolution dependency on the pulse length and width to produce SURUS (super-resolution ultrasound) images. The pulse shapes have stable inverses, derived by use of the standard Z-transform and related properties. | 12-12-2013 |
20130330311 | ANTIGEN-PRESENTING PLATELETS AND METHODS OF ELICITING AN IMMUNE RESPONSE - Provided herein are methods of producing an antigen-presenting platelet. Also provided herein are methods of eliciting an immune response in a subject using the antigen-presenting platelets described herein. Also provided are methods of screening for an immune response elicited by an antigen-presenting platelet. Further provided are isolated populations of platelets that present a selected antigen produced by the methods described herein. | 12-12-2013 |
20130329862 | BACKSCATTER REDUCTION DEVICE (BSR) - A backscatter reduction device has a lead or lead-equivalent density sheet or foil inside a cover, such as a rigid or semirigid plastic cover. The device is placed behind an x-ray imaging plate without backscatter protective measures, thereby significantly reducing and/or eliminating backscatter radiation from backscattering objects such as the patient's bed frame. The backscatter reduction device can be combined with a radiographic grid. | 12-12-2013 |
20130317087 | METHODS AND COMPOSITIONS RELATED TO STAUFEN 1 BINDING SITES FORMED BY DUPLEXING ALU ELEMENTS - Disclosed are compositions and methods for identifying binding sites of targets of Staul-mediated mRNA decay; methods and compositions for treating subjects with conditions resulting from Staul-mediated mRNA decay, and method of screening for therapeutic agents. Also disclosed is the new pathway as a means for cells to down-regulate the expression of Staul-binding mRNAs. | 11-28-2013 |
20130304118 | Devices and Methods for Vascular Closure - Devices and methods for vascular closure are disclosed. The invention may be an apparatus having a first catheter comprising a first balloon lumen and a support balloon in pneumatic communication with the first balloon lumen, a sheath having a hood portion, a second catheter comprising a second balloon lumen and an expander balloon in pneumatic communication with the second balloon lumen, and a pusher assembly having a bandage. A method of using such an apparatus may comprise the steps of inserting the apparatus into the vasculature through the puncture, positioning the sheath outside of the puncture, inflating the support balloon, inserting the second catheter into the sheath, inflating the expander to expand the hood portion of the sheath, deflating the expander balloon, positioning the pusher assembly within the hood portion, deflating the support balloon, removing the first catheter, and affixing the bandage on the puncture. | 11-14-2013 |
20130303585 | SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE - Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection. | 11-14-2013 |
20130296386 | SMALL MOLECULE RNASE INHIBITORS AND METHODS OF USE - Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. | 11-07-2013 |
20130295162 | FLAVIVIRUS DOMAIN III VACCINE - The disclosure provides a tetravalent Dengue virus vaccine, and methods of inducing a immune response against a Flavivirus such as Dengue virus 1-4 using the vaccine. The disclosure also provides methods of making a vaccine by introducing into a host cell a transgene that encodes a protein comprising Dengue domain III polypeptides, or, by purified dill polypeptides specific for Dengue serotypes 1-4, Yellow Fever Virus, West Nile Virus, Japanese Encephalitis Virus, and Flaviviruses. | 11-07-2013 |
20130252841 | ARRAYED DETECTOR SYSTEM FOR MEASUREMENT OF ANTI-VIRAL IMMUNE RESPONSE - A sensor chip for detecting an immune response against a virus, the sensor chip including a substrate having a surface and a plurality of virus-like particles or capsid fragments bound to discrete locations on the surface of the substrate. Detection devices containing the sensor chip and methods of detecting anti-viral immune responses are also described herein. | 09-26-2013 |
20130252334 | METHOD OF USING TET-INDUCIBLE TRANSGENES - The invention relates to a method of using an inducible transgene in a cell, where the inducible transgene expresses a gene product having activity on a cell death or cell survival pathway. The method includes exposing the cell to an agent that is capable of inducing the inducible transgene but also has direct activity on a cell death or cell survival pathway, said exposing being carried out in a manner effective to induce expression of the transgene while substantially minimizing said direct activity of the agent. Host cells and kits for carrying out the method are also disclosed. | 09-26-2013 |
20130237585 | MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION - Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof. | 09-12-2013 |
20130230462 | METHOD FOR PREDICTING AND PREVENTING CARDIOVASCULAR DISEASE - Disclosed are methods of identifying an individual having a predisposition to the development of a cardiovascular disease, and administering a suitable prophylactic agent to the identified individual to prevent disease. Methods of screening and identifying agents that inhibit bacterial collagen binding protein (CBP)-mediated cell invasion are also disclosed. | 09-05-2013 |
20130227402 | SYSTEM, APPARATUS, METHOD, AND APPLICATIONS FOR MEASURING AND REPORTING ON THE PROCESS OF COMPOSING WRITTEN MATERIAL - Tools in the form of hardware apparatus, software components, a system comprising hardware apparatus and software components, methods, and applications of said system and methods, which pertain to and enable the analysis of and reporting about the process of composing written material; i.e., the process of writing. An important and distinguishing attribute of at least certain aspects of the embodied invention is its utilization of software that unobtrusively measures and reports on how people write; i.e., again, the process of writing. | 08-29-2013 |
20130210055 | SYSTEM AND METHOD FOR STUDYING EPIDERMIS SAMPLES EX VIVO - An epidermal sample is placed into a sample holder formed as a sandwich assembly. The sample holder is placed in an upper well within a lower well to be exposed to media in both wells. Properties of the sample can be studied, such as paracellular flux, transepidermal electric resistance, reaction to compounds, and epidermal barrier recovery. | 08-15-2013 |
20130209471 | DC-STAMP ANTIBODIES - Provided herein are antibodies that specifically bind an epitope of DC-STAMP. Specifically, provided herein are monoclonal antibodies that bind an epitope of DC-STAMP, wherein the epitope comprises the amino acid sequence Glu-Val-His-Leu-Lys-Leu-His-Gly-Glu-Lys-Gln-Gly-Thr-Gln (SEQ ID NO:1). Optionally, the epitope comprises the amino acid sequence His-Gly-Glu-Lys-Gln-Gly-Thr-Gln (SEQ ID NO:2). Optionally, the epitope comprises the amino acid sequence Lys-Gln-Gly-Thr-Gln (SEQ ID NO:3). | 08-15-2013 |
20130205499 | SUPPORT BRACKET FOR MEDICAL EQUIPMENT AND USES THEREOF - The present invention relates to a medical support device and uses thereof. The medical support device includes a stem defining a longitudinal axis, the stem having an upper end and a lower end, the lower end adapted for securing the device to a receptacle. The medical support device also includes an elongate member permanently secured to the stem and extending outwardly from said stem at an angle to the longitudinal axis, the elongate member having an end proximate to said stem and an end distal to said stem, and a plurality of medical equipment support elements fixed to a lower surface of the elongate member between the distal end and a point intermediate the proximal and distal ends. | 08-15-2013 |
20130203755 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE - Provided are compounds having an inhibitory effect on kinases including Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders that comprise the inhibition of Mixed Lineage Kinases. | 08-08-2013 |
20130203101 | METHOD AND SYSTEM FOR PURIFYING AND QUANTITATING PROTEINS USING HEME FUSION TAGS - A method is provided for purifying a protein comprising the steps of providing a heme tag with an open coordination site and tagging the recombinant protein of interest with the heme tag. A resin framework is used, wherein a base that binds to heme is immobilized to the resin, and the open coordination site of the heme tag is capable of reversibly binding to the base immobilized to the resin. The tagged protein is reversibly bound to the resin, then eluted from the resin and quantified. The method enables the tagged protein to be tracked during protein expression or purification, and can be used to identify secretion of a protein to the periplasm or to tag proteins in the cytoplasm. | 08-08-2013 |
20130198207 | INTEGRATED MULTI-CRITERIA DECISION SUPPORT FRAMEWORK - Integrated multi-criteria decision frameworks disclosed herein can facilitate making good decisions when faced with a complex choice among several alternatives with different combinations of strengths and weaknesses. Some decision support systems using multi-criteria methods can combine multiple multi-criteria methods in a single adaptable decision support intervention. In some embodiments, the framework can include some or all of the following modules: a decision strategy module; a balance sheet module; an interactive decision dashboard module; an ordinal ranking module; a direct weighting module; and an Analytic Hierarchy Process (AHP) module. | 08-01-2013 |
20130197064 | METHOD AND COMPOSITION FOR ALVEOLAR EPITHELIAL CELL-SPECIFIC NUCLEIC ACID NUCLEAR IMPORT - One aspect of the invention relates to an isolated nuclear targeting molecule that includes a fragment of a mammalian glycoprotein 36 (gp36, also known as T1-α or podoplanin) gene expressed in type I alveolar epithelial cells. Plasmids containing the isolated nuclear targeting molecule which are useful for affording nuclear uptake of the plasmid DNA in type I alveolar epithelial cells but not type II alveolar epithelial cells, and compositions and host cells containing such plasmids are also disclosed. Use of the plasmids for targeting an exogenous DNA into nuclei of type I alveolar epithelial cells is described herein. | 08-01-2013 |
20130196409 | Targeted 2'-O-Methylation of Telomerase Non-Coding RNA - Processes and C/D box small nucleolar RNAs (snoRNAs) for altering telomerase activity and altering telomerase length are described. The processes of the invention involve the use of C/D box snoRNAs for targeted 2′-O-methylation modification of nucleotides in a pseudoknot region of the telomerase RNA. Depending on their position, the 2′-O-methylation modifications can cause an increase in telomerase activity and subsequent telomere lengthening or a decrease in telomerase activity and subsequent telomere shortening. | 08-01-2013 |
20130190848 | Implantable Devices That Generate Low Intensity Electric Fields For The Treatment of Atherosclerotic Disease And Prevention of Ischemic Vascular Events and Methods of Manufacture - An internal medical device for implantation into a human or animal where the internal medical device has an electric field source that may be an active source of electromotive force such as a battery or capacitor, or may be an electric field generating material such as an electret, piezoelectric, or the like. | 07-25-2013 |
20130190224 | TREATMENT OF FIBROSIS-RELATED DISORDERS USING FIBRONECTIN BINDING PROTEINS AND POLYPEPTIDES - The present invention is directed to various uses of fibronectin binding proteins or polypeptides for treating and preventing fibrosis and fibrosis related conditions. The fibronectin binding proteins and polypeptides are also useful for treating conditions associated with vascular remodeling and cardiac dysfunction. | 07-25-2013 |
20130189275 | COMPOSITIONS AND METHODS FOR INHIBITION OF OR TREATMENT OF DENGUE VIRUS INFECTION - The present invention relates to a method of interfering with dengue infection comprising interfering with dengue virus binding to a syndecan present on a cell targeted by dengue virus. The present invention further relates to treating a patient for dengue virus infection comprising administering to a patient, either having a dengue infection or a patient exposed to dengue infection, an effective amount of an agent that interferes with dengue virus binding to a syndecan on a surface of a cell targeted by dengue virus. The present invention further relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier, and an effective amount of an agent that interferes with dengue virus binding to a syndecan on a surface of a cell targeted by dengue virus. | 07-25-2013 |
20130184223 | METHODS AND COMPOSITIONS RELATED TO MODULATING AUTOPHAGY - Disclosed are compositions and methods related to new targets for cancer treatment the modulation of autophagy. | 07-18-2013 |
20130172395 | COMPOUNDS FOR ANTI-FUNGAL TREATMENT - Provided are methods of treating or preventing a fungal infection in a subject. The methods comprise selecting a subject with or at risk of developing a fungal infection and administering to the subject a therapeutically effective amount of toremifene and fluconazole or derivatives thereof. | 07-04-2013 |
20130165778 | Shear Modulus Estimation by Application of Spatially Modulated Impulse Acoustic Radiation Force Approximation - A method for determining a shear modulus of an elastic material with a known density value is provided. In this method, a spatially modulated acoustic radiation force is used to initially generate a disturbance of known spatial frequency or wavelength. The propagation of this initial displacement as a shear wave is measured using ultrasound tracking methods. A temporal frequency is determined based on the shear wave. The shear modulus of the elastic material at the point of excitation may be calculated using the values of the spatial wavelength, material density, and temporal frequency. | 06-27-2013 |
20130156753 | THE cAMP/PKA/HDAC5 PATHWAY AND USES THEREOF - The present invention provides novel uses of the cAMP/PKA/HDAC5 pathway for the treatment and prevention of myopathies. | 06-20-2013 |
20130138093 | OPTICAL MATERIAL AND METHOD FOR MODIFYING THE REFRACTIVE INDEX - An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer. | 05-30-2013 |
20130136753 | PAXILLIN AS A THERAPEUTIC OR DIAGNOSTIC MARKER FOR CANCER - The present invention relates to methods for assessing the aggressiveness or proliferative activity of a cancer that is capable of both androgen-dependent and steroid-independent growth and proliferation; as well as methods and therapeutic agents for the treatment of such cancers including, among others, prostate cancers, testicular cancers, breast cancers, endometrial cancers, uterine cancers, and ovarian cancers. | 05-30-2013 |
20130133483 | Synthesis of Nanoparticles Using Reducing Gases - Selective gas-reducing methods for making shape-defined metal-based nanoparticles. By avoiding the use of solid or liquid reducing reagents, the gas reducing reagent can be used to make shape well-defined metal- and metal alloy-based nanoparticles without producing contaminates in solution. Therefore, the post-synthesis process including surface treatment become simple or unnecessary. Weak capping reagents can be used for preventing nanoparticles from aggregation, which makes the further removing the capping reagents easier. The selective gas-reducing technique represents a new concept for shape control of nanoparticles, which is based on the concepts of tuning the reducing rate of the different facets. This technique can be used to produce morphology-controlled nanoparticles from nanometer- to submicron- to micron-sized scale. The Pt-based nanoparticles show improved catalytic properties (e.g., activity and durability). | 05-30-2013 |
20130131009 | Compositions Comprising High Molecular Weight Hyaluronic Acid and Methods For Producing Same - This invention provides cell culture compositions which produce significant quantities of high molecular weight hyaluronic acid. The cell cultures are obtained from cells of mole rats, such as naked mole rats and blind mole rats. The high molecular weight hyaluronic acid can be collected in the conditioned media of these cell cultures. These cell cultures provide a convenient source of large quantities of high molecular weight hyaluronic acid. | 05-23-2013 |
20130123285 | Compositions and Methods for Targeting A3G:RNA Complexes - The present invention provides an assay for screening any agent that modulates the ability of A3G to bind with RNA. The invention provides an agent identified by high throughput screening methods and methods of treatment using the identified agent as a means of inhibiting HIV infection and reducing the emergence of viral drug-resistance. | 05-16-2013 |
20130116674 | SYSTEM AND METHOD FOR TREATING VISION REFRACTIVE ERRORS - Disclosed is a computer-implemented method for correcting refractive errors in a living eye using a laser vision correction system that involves first calculating an amount of sphere based on preoperative manifest refraction and higher order aberrations data associated with the eye, and then correcting for the calculated amount of sphere by ablating at least a portion of the eye. The preoperative manifest refraction may include preoperative manifest sphere, preoperative spherical equivalent, regular astigmatism, and oblique astigmatism, and the preoperative higher-order aberrations may include 4th-order spherical and 3rd root mean square. Other factors may also be used to adjust the calculated amount of sphere. A device readable medium for storing the calculation and instructions for operating a laser vision correction system for practicing the method is also disclosed, as is a method of treating refractive errors. | 05-09-2013 |
20130116313 | Compositions and Methods for Inhibiting G Protein Signaling - The present invention relates to methods for identifying agents which bind to specific amino acid residues of the protein interaction site of G protein β protein subunit. Compounds identified in accordance with the assay of the invention and methods for using the compound for modulating at least one activity of a G protein are also provided. | 05-09-2013 |
20130115364 | RESIN-INFILTRATED CERAMICS - Porous ceramic materials, including dental prostheses, may be infiltrated by a solution comprising resin monomers and a solvent for lowering viscosity of the solution. Infiltration may be achieved by providing the ceramic and the solution in a low pressure environment, followed by a polymerizing process whereby the resin is cross-linked within the pores of the ceramic. The solvent may be removed, for example, to leave substantially only the polymerized resin within the ceramic. | 05-09-2013 |
20130110249 | ANTI-GLUCOSAMINIDASE PASSIVE IMMUNIZATION FOR STAPHYLOCOCCUS AUREUS INFECTIONS | 05-02-2013 |
20130102875 | LOW-COST DEVICE FOR C-SCAN PHOTOACOUSTIC IMAGING - The prostate gland or other region of interest is stimulated with laser light, resulting in ultrasound waves (photoacoustic effect) which are focused by an acoustic lens and captured by a specific 1- or 2D sensor array and subsequently displayed as a C-scan on a computer screen. The amplitude of the ultrasound waves generated by laser stimulation is proportional to the optical absorption of the tissue element at that spatial location. Variability in tissue absorption results in C-scan image contrast. The photoacoustic imaging is combined with an ultrasound C-scan image produced with a plane ultrasound wave applied to the region of interest. | 04-25-2013 |
20130096175 | Compounds and Methods for Altering Lifespan of Eukaryotic Organisms - Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation. | 04-18-2013 |
20130089516 | PROTEASE ACTIVATED CYTOKINES - Provided herein are chimeric nucleic acid sequences encoding chimeric polypeptides. Also provided herein are chimeric polypeptides. Further provided herein are methods of treating a subject with or at risk of developing a cancer. The methods comprise selecting a subject with or at risk of developing a cancer, and administering to the subject an effective amount of the chimeric polypeptides provided herein. | 04-11-2013 |
20130085110 | RECOMBINANT FACTOR VIII HAVING INCREASED STABILITY - The present invention relates to a recombinant factor VIII that includes one or more mutations that result in enhanced stability of both factor VIII and factor VIIIa. Methods of making and using the recombinant factor VIII, and pharmaceutical compositions containing the same are also disclosed. The present invention further relates to an isolated nucleic acid molecule that encodes the recombinant factor VIII, as well as DNA expression systems and host cells containing the isolated nucleic acid molecule. | 04-04-2013 |
20130085097 | PAPILLOMAVIRUS VIRUS-LIKE PARTICLE OR CAPSOMERE FORMULATION AND ITS USE AS MICROBICIDE - Methods and compositions for preventing viral infection are disclosed. Compositions containing papillomavirus VLPs or capsomeres are used, alone or in combination with other agents, as microbicides that substantially block papillomavirus binding receptors on the surface or vicinity of cells in a tissue to be treated with the composition. The invention can be used to inhibit papillomavirus infection or infection by another virus that utilizes the same binding receptors during the infection process. | 04-04-2013 |
20130078740 | PREPARATION OF MICROFLUIDIC DEVICE ON METAL NANOPARTICLE COATED SURFACE, AND USE THEREOF FOR NUCLEIC ACID DETECTION - The invention relates to a microfluidic device that utilizes nucleic acid-based detection and a detection system containing the same, as well as a process for preparing the micro fluidic device and for using the same to detect the presence of a target nucleic acid molecule in a sample. | 03-28-2013 |
20130063804 | DIGITAL BINARY MEMS WAVEFRONT CONTROL - Embodiments of the invention are directed to a new type of phase screen, i.e., an opto-electronic device that can convert a distorted incoming optical wavefront into a plane wave or, conversely, transform a plane wave into a prescribed varying output wavefront. The basic concept involves novel binary all-digital MEMS interferometer configurations that can be used to create controlled and arbitrary optical wavefront using only 0,1 amplitude changes followed by differential propagation distances to convert these amplitude variations into controllable and/or continuous phase variations. Clustered pixel notions, such as Floyd-Steinberg, Stucki or other algorithms useful in digital half-tone printing, are simultaneously employed to create controllable grey-level variations as well as continuous phase variations. Desired grey-levels can be obtained wherein each pixel is formed by, e.g., a 3×3 or 5×5 cluster of mirrors. Both the filling-in of the outputs of the binary mirror (0,1) and the grey-levels are accomplished simply by spatial averaging over a short propagation distance. | 03-14-2013 |
20130057873 | SYSTEM AND METHOD FOR MEASURING THE RATIO OF FORWARD-PROPAGATING TO BACK-PROPAGATING SECOND HARMONIC-GENERATION SIGNAL, AND APPLICATIONS THEREOF - A method and system that enable the measurement of a second-harmonic-generation-forward/backward (SHG F/B) ratio from an object by performing only a single image scan using via epi-imaging using an epi-detection technique. Two simultaneous SGH images (a forward propagating SHG “F” image and a back propagating SHG “B” image) are generated during the single image scan. A pinhole mirror can be used to separate the F-SHG and the B-SHG, which are detected by separate detectors. | 03-07-2013 |
20130046257 | METHODS OF USING AGENTS THAT MODULATE CLAUDIN EXPRESSION - This invention relates to the use of agents that modulate claudin-1 and/or -23 expression or activity for purposes of regulating tight junction (“TJ”) formation among keratinocytes that express claudin-1 and/or -23, or other cell types that over- or under-express claudin-1 and/or -23. Several aspects of the present invention relate to increasing claudin-1 and/or -23 expression or function to enhance tight junction formation among claudin-1 and/or -23 expressing cells, particularly keratinocyte and antigen presenting cells. Several other aspects of the invention relate to decreasing claudin-1 and/or -23 expression or function to diminish tight junction formation among claudin-1 and/or -23 expressing cells, particularly keratinocytes and antigen presenting cells. Transdermal drug and vaccine formulations including agent(s) that decrease -1 and/or -23 expression or function to diminish tight junction formation among claudin-1 and/or -23 expressing cells, as well as a trans dermal patch for delivering the same, are also included. | 02-21-2013 |
20130045267 | METHODS OF USING AGENTS THAT MODULATE CLAUDIN EXPRESSION - Methods are provided for modulating expression of claudin-1 and/or claudin-23, for purposes of regulating formation of tight junctions in keratinocytes or other types of cells such as antigen presenting cells (e.g., dendritic cells and Langertians cells), by either increasing or decreasing expression of claudin-1 and/or claudin-23. Also provided are transdermal formulations that decrease expression of claudin-1 and/or claudin-23, thereby diminishing tight junction formation in cells expressing claudin-1 and/or claudin-23, as well as a transdermal patch for delivering the same. | 02-21-2013 |
20130044313 | Broad Band Czerny-Turner Spectrometer, Methods, and Applications - A low-cost optics, broadband, astigmatism-corrected practical spectrometer. An off-the-shelf cylindrical lens is used to remove astigmatism over the full bandwidth, providing better than 0.1 nm spectral resolution and more than 50% through-put over a bandwidth of 400 nm centered at 800 nm. The spectrometer includes a first spherical mirror disposed along an optical path in an off-axis (tilted) orientation; a diffraction grating disposed along the optical axis in a location optically downstream from the first mirror; a second spherical mirror disposed along the optical path in an off-axis orientation in a location optically down-stream from the diffraction grating; a cylindrical optic disposed in the optical path; and a detector disposed in the optical path in a location optically downstream from the second spherical mirror. | 02-21-2013 |
20130044190 | THREE-DIMENSIONAL MODEL ACQUISITION USING PLANAR MIRRORS - -D model acquisition of an object is performed using two planar mirrors and a camera. According to some embodiments, | 02-21-2013 |
20130039927 | ANTIGENIC MIMICS OF DISCONTINUOUS EPITOPES OF PATHOGEN RECOGNIZED BY BROADLY NEUTRALIZING ANTIBODIES - The present invention relates to an anti-idiotypic polypeptide scaffold that includes two or more peptide sequences that mimic a discontinuous epitope of a pathogen that is recognized by or induces formation of a broadly neutralizing antibody. Using a fibronectin FNfn10 scaffold bearing two or more modified discontinuous loops, scaffolds that recognize broadly neutralizing antibodies in vitro and from patient serum have been identified. These scaffolds should induce an immune response or mobilize germline specificities to initiate their affinity maturation. | 02-14-2013 |
20130028565 | LIGHT COLLECTING AND EMITTING APPARATUS, METHOD, AND APPLICATIONS - A light guide apparatus includes a light guide layer and an injection layer further including light injection elements and respective light bypass elements disposed optically upstream of the light injection elements. The light injection elements and/or the bypass elements may take the form of air prisms. There is an axial index of refraction variation between the light guide layer and the injection layer. The axial index of refraction variation may be discrete or may be an axial gradient index variation. | 01-31-2013 |
20130012413 | IN VITRO ASSAYS FOR ENRICHING AND DETERMINING THE CLONOGENIC POTENTIAL OF STEM CELLS - A method of enriching stem or progenitor cells that includes growing a heterogeneous cell sample comprising stem and/or progenitor cells on a first substrate that is hydrophobic and has an elastic modulus less than about 100 MPa; recovering the heterogeneous cell sample from the first substrate; growing the recovered heterogeneous cell sample on a second substrate that is hydrophilic and has an elastic modulus higher than the elastic modulus of the first substrate to produce a subpopulation of nonadherent cells and a subpopulation of adherent cells; and recovering the nonadherent cell subpopulation, which is enriched for stem and/or progenitor cells. The invention also relates to a method of determining the clonogenic potential of a cell, such as a cancer stem cell enriched using the enrichment method described herein. | 01-10-2013 |
20130005676 | ENHANCING THE THERAPEUTIC EFFECT OF ACUPUNCTURE WITH ADENOSINE - The present invention relates to a method of improving the therapeutic effect of acupuncture in a subject. The method involves administering adenosine, an adenosine mimetric, an adenosine modulator, an adenosine transport inhibitor, enzymes involved in adenosine metabolism, and/or an adenosine receptor agonist to the subject under conditions effective to improve the therapeutic effect of the acupuncture. | 01-03-2013 |
20130004467 | MYELINATION OF CONGENITALLY DYSMYELINATED FOREBRAINS USING OLIGODENDROCYTE PROGENITOR CELLS - One form of the present invention is directed to a method of remyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes. A further aspect of the present invention relates to an in vitro method of identifying and separating oligodendrocyte progenitor cells from a mixed population containing other mammalian brain or spinal cord cell types. | 01-03-2013 |
20130003016 | CALIBRATION DEVICE FOR USE WITH A FUNDUS CAMERA - A calibration device for use with a fundus camera is described, including a mock retina having a curvature from a front portion to a back portion. The calibration device further includes a color model having a range of colors comparable to a range of colors of the fundus of an eye. The calibration device further can include a lens for magnification and is configured to facilitate generation of an image to evaluate and adjust an ophthalmic imaging system for features such as color, magnification, and resolution. | 01-03-2013 |
20120328905 | NANOSTRUCTURED MATERIALS, METHODS, AND APPLICATIONS - Methods for making a material superwicking and/or superwetting (superhydrophyllic) involving creating one or more indentations in the surface of the material that have a micro-rough surface of protrusions, cavities, spheres, rods, or other irregularly shaped features having heights and/or widths on the order of 0.5 to 100 microns and the micro-rough surface having a nano-rough surface of protrusions, cavities, spheres, rods, and other irregularly shaped features having heights and/or widths on the order of 1 to 500 nanometers. Superwicking and/or superwetting materials having micro-rough and nano-rough surface indentations, including metals, glass, enamel, polymers, semiconductors, and others. | 12-27-2012 |
20120328631 | EP1 INHIBITION - Provided herein are methods of accelerating bone fracture healing in a subject. Also provided herein are methods of treating or preventing osteoporosis in a subject. Further provided are methods of screening for an agent that accelerates bone fracture healing or treats or prevents osteoporosis. | 12-27-2012 |
20120327368 | METHOD AND APPARATUS FOR IMAGING IN AN EYE - A scanning laser ophthalmoscope (SLO) that includes at least one adjustable scanning system adapted for a variable field of view; at least one light source having at least a first spectral emission band suitable to effect at least one of a fluorescence signal and a reflectance signal from a retinal cell; and at least one detector configured to detect at least two different spectral bands from the at least one of the fluorescence and reflectance signals. | 12-27-2012 |
20120325003 | SYSTEM AND METHOD FOR IDENTIFYING, INSPECTING, AND EXAMINING A RADIOGRAPHICALLY LABELED SPECIMEN - An apparatus for determining the location of a radio-opaque marker embedded in an excised specimen includes a radio-opaque marker including an energy beacon that can be embedded in the specimen, an energy beacon controller, at least three detectors, a signal processing component, and a display device. An associated method is disclosed. A method for evaluating a radiographically labeled excised specimen involves determining the location of a radio-opaque marker embedded in the excised specimen, anatomically sectioning the excised specimen, macro-optically segmenting the sectioned specimen into an adipose tissue component, a fibrous tissue component, and an epithelial tissue component, and microscopically examining at least one of the tissue components. An associated apparatus is disclosed. | 12-27-2012 |
20120310223 | METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES AND APPLICATIONS THEREOF - A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction. | 12-06-2012 |
20120294837 | METHODS OF ISOLATING AND CULTURING MESENCHYMAL STEM CELLS - Provided herein is a relatively pure population of mesenchymal stem cells (MSCs) expressing the Notch 2 receptor (Notch 2+ a MSCs). Also provided is a method of isolating from a subject a population of Notch 2+ MSCs and a method of culturing the population of Notch 2+ MSCs. Also provided is a method of treating a subject with a disorder associated with a deficiency or defect in cells of mesenchymal lineage comprising administering a population of Notch 2+ MSCs to the subject. | 11-22-2012 |
20120286452 | MICROFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE MICROFLUIDIC DEVICE - A microfluidic device having a substrate with an array of curvilinear cavities. The substrate of the microfluidic device is preferably fabricated of a polymer such as polydimethylsiloxane. The microfluidic device is manufactured using a gas expansion molding technique. | 11-15-2012 |
20120277520 | TRANSCUTANEOUS MAGNETIC ENERGY TRANSFER DEVICE - Transcutaneous magnetic energy transfer to drive a VAD or other implanted medical device can be supplied through two spinning (or otherwise moving) permanent magnets, or a moving permanent magnet and a moving ferric material, or a moving permanent magnet and a coil or an array of coils, One part is implanted under the patient's skin, so that the skin does not have to be broken for a connection to take place. | 11-01-2012 |
20120267337 | ULTRATHIN POROUS NANOSCALE MEMBRANES, METHODS OF MAKING, AND USES THEREOF - A process for forming a porous nanoscale membrane is described. The process involves applying a nanoscale film to one side of a substrate, where the nanoscale film includes a semiconductor material; masking an opposite side of the substrate; etching the substrate, beginning from the masked opposite side of the substrate and continuing until a passage is formed through the substrate, thereby exposing the film on both sides thereof to form a membrane; and then simultaneously forming a plurality of randomly spaced pores in the membrane. The resulting porous nanoscale membranes, characterized by substantially smooth surfaces, high pore densities, and high aspect ratio dimensions, can be used in filtration devices, microfluidic devices, fuel cell membranes, and as electron microscopy substrates. | 10-25-2012 |
20120265552 | DEVICES AND METHODS FOR CLINICAL MANAGEMENT AND ANALYTICS - Devices and methods for clinical management and analytics can include a dashboard configured to be displayed on a device. Dashboards can include one or more graphs including a representation of a total number of patients and a set of the patients that have a common status relative to a metric. One or more of the graphs can include an area that is representative of the set of patients. The area can be selected to display information associated with the set of patients. The information can comprise contact information, demographic information, or health care cost information, for example. | 10-18-2012 |
20120253188 | REDUCING RISK OF COMPLICATIONS ASSOCIATED WITH TISSUE ABLATION - Methods and systems are described that reduce risks of hematologic, metabolic, and renal complications in a mammal, such as a human, undergoing tissue ablation. One such method includes inserting a probe into a mammal and ablating abnormal tissue in the mammal by emitting a first amount of energy from the probe. In some embodiments, after emitting the first amount of energy, a method can include denaturing proteins released from cells in the abnormal tissue by emitting a second amount of energy from at least one of the first probe or a second probe inserted into the mammal. Furthermore, some embodiments can be implemented such that during or after the emitting the energy from a probe, a composition is administered to the mammal in an effective amount to denature proteins released from cells in the abnormal tissue. | 10-04-2012 |
20120251629 | METHODS OF TREATMENT AND SCREENING ASSAYS FOR HIF-1ALPHA REGULATION - The present invention relates to a method of treating a patient for a condition where blood flow to a tissue or organ is interrupted. This method involves administering to a patient with a hypoxic condition where blood flow to a tissue or organ is interrupted, or at risk thereof, a compound that reduces the rate of HIF-1α inactivation in cells affected by the condition, thereby treating the patient for the condition. Also disclosed is a method of treating a tumor in a patient. In addition, the present invention relates to methods of identifying compounds as candidate drugs for treatment of hypoxic conditions and for treating tumors in a subject. | 10-04-2012 |
20120245952 | CROWDSOURCING MEDICAL EXPERTISE - Methods of crowdsourcing medical expert information are described. One such method includes receiving, from a first user during a first session over a network, a first query that includes a request for information regarding a patient condition, a therapy, and/or a medical test, and transmitting the query to a plurality of medical personnel. The first query further includes first session parameters selected by the first user from categories displayed by a processor to the first user. The method also includes receiving responses to the query from the plurality of medical personnel, and changing, based on the responses, an assigned probability of presenting to an index user, in response to a second query and during another session, at least one of a suggested diagnosis, a suggested therapy, a suggested inquiry to aid in establishing a diagnosis, a suggested medical test, a recommended source for further information, or a recommended medical professional. | 09-27-2012 |
20120244555 | METHOD OF DIAGNOSING MILD TRAUMATIC BRAIN INJURY - The present invention relates to a method of determining whether a subject has suffered a mild traumatic brain injury. The method comprises selecting a subject exposed to a head trauma; and determining whether a body fluid sample obtained from the selected subject comprises smaller than normal high density lipoprotein (HDL) particles, larger than normal HDL particles, or both; wherein detection of the smaller than normal HDL particles, larger than normal HDL particles, or both, indicates that the subject has suffered a mild traumatic brain injury. | 09-27-2012 |
20120243114 | NONSYMMETRIC OPTICAL SYSTEM AND DESIGN METHOD FOR NONSYMMETRIC OPTICAL SYSTEM - A new family of truly nonsymmetric optical systems that exploit a new fabrication degree of freedom enabled by the introduction of slow-servos to diamond machining; surfaces whose departure from a sphere varies both radially and azimuthally in the aperture, and associated design method. | 09-27-2012 |
20120243001 | OPTICAL TESTING APPARATUS AND METHODS - An apparatus and associated method for testing a non-symmetric (e.g., phi-polynomial) surface. The apparatus uses several simple (singlet) optical elements (e.g., an Offner null configuration) and a tilted optic under test in combination with an active optical element (e.g., actuated, deformable membrane mirror, optical phase modulator, etc.) that together form a null or quasi-null that allows for conventional null-based interferometry. This solution solves the problem of exceeding the dynamic range of a conventional interferometer when trying to test non-symmetric optical surfaces. | 09-27-2012 |
20120225793 | METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS - Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject. | 09-06-2012 |
20120218285 | METHODS AND SYSTEMS FOR TREATMENT OF VESTIBULAR DISORDERS - Methods and systems for assessing and treating vestibular disorders can include displaying a graphic and providing relative movement between the graphic and a user's head. Information can be obtained either directly or indirectly from the user regarding her perception of the graphic. A graphic display parameter and/or a relative movement parameter can be modified in response to the information regarding the user's perception. An indicator of the user's ability to perceive the graphic can be generated through a series of iterations. A graphic display parameter and/or a relative movement parameter for use in a subsequent series of iterations can be modified based at least in part on the indicator. | 08-30-2012 |
20120209369 | FENESTRATED ENDOGRAFT - A fenestrated endograft having an expandable stent frame and a lumen is described herein. The stent frame has a proximal end portion, a distal end portion, and a central portion. The central portion may include a fabric that has an aperture partially surrounded by part of the expandable stent frame. The lumen extends through the proximal end portion, the central portion, and the distal end portion. The stent frame is radially expandable from a collapsed configuration to an expanded configuration. The central portion is coupled to a fabric, which extends about a perimeter of the central portion. The fabric has an aperture with a cross-sectional dimension that is substantially equal to a cross-sectional dimension of an outer cross-sectional dimension of the distal end portion. The central portion has a curved elongate member, which includes a curved segment extending around at least one-fourth of a perimeter of the aperture. | 08-16-2012 |
20120183524 | MOLECULAR TARGETS FOR TREATMENT OF INFLAMMATION - Molecular targets and methods for treating inflammatory disorders are described. The expression and/or functionality of molecular targets RelB or SIRT1 is modified in order to treat inflammatory disorders. The expression of RelB or SIRT1 may be increased, or the activity of RelB or SIRT1 may be increased in order to inhibit transcription factors which activate genes involved in inflammation. Inflammatory disorders such as chronic obstructive pulmonary disorder, rheumatoid arthritis, asthma and idiopathic pulmonary fibrosis are indicated. | 07-19-2012 |
20120165403 | METHODS OF INHIBITING THE ACTIVITY OF HSP90 AND/OR ARYL HYDROCARBON RECEPTOR - The present invention relates to a method of screening compounds for binding to hsp90 by exposing a compound to hsp90 or a polypeptide fragment thereof containing amino acid residues 538-728 of the full length protein and determining whether the compound binds to hsp90 of the polypeptide fragment thereof. Also disclosed is a method of screening compounds for inhibition of hsp90 activity. The present invention further relates to a method of screening compounds as a cancer therapeutic and a method of treating cancerous conditions. Also disclosed is a method of inhibiting transcription-inducing activity of an aryl hydrocarbon receptor in a cell and a method of modifying expression of a gene that is activated by an aryl hydrocarbon receptor. | 06-28-2012 |
20120141552 | ULTRASOUND TECHNOLOGY TO CONTROL THE SPATIAL ORGANIZATION OF CELLS AND PROTEINS IN ENGINEERED TISSUES - The present invention is directed to methods of inducing spatial organization of cells an in vitro culture system using ultrasound technology. The invention is further directed to methods of inducing extracellular matrix remodeling and neovessel formation in an in vitro culture system and generating vascularized engineered tissue constructs using ultrasound technology. | 06-07-2012 |
20120130486 | MULTIFOCAL OPHTHALMIC LENS DESIGNS USING WAVEFRONT INTERACTION - An intraocular lens introduces higher order aberrations, e.g., spherical aberration (SA), for different sub-optical zone diameters. For example, a lens may have a central sub-optical zone which introduces a spherical aberration. Alternatively, a full optical zone design can be used combining defocus with a higher-order aberration. | 05-24-2012 |
20120127432 | MEASURING OCULAR POINT SPREAD FUNCTION USING ADAPTIVE OPTICS - Measurement of the optical point spread function through a double-pass technique is enhanced by using adaptive optics to form a tiny spot of light on the retina. | 05-24-2012 |
20120127431 | SCANNING OPTICAL SYSTEM FOR LARGE AXIAL SCAN DEPTH ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY (OCT) - An optical coherence tomography scanning system includes a lens divided into two halves: one optimized to achieve normal incidence angles on the posterior surface of the eye's lens, the other optimized for the anterior surface of the eye's lens. | 05-24-2012 |
20120123534 | MODIFIED MONOVISION BY EXTENDING DEPTH OF FOCUS - Depth-of-focus (DoF) is extended in a presbyopic patient by inducing different higher order aberrations, e.g. spherical aberration, to each of the two eyes. That method will result in improving binocular through-focus visual performance and outperform traditional monovision. The aberration can be induced in any suitable way, such as by an intraocular lens or a contact lens. | 05-17-2012 |
20120122872 | Treatment or Prevention of Fungal Infections with PDK1 Inhibitors - Provided are methods of treating or preventing a fungal infection in a subject. The methods comprise identifying a subject with or at risk of developing a fungal infection and administering to the subject a therapeutically effective amount of an inhibitor or a fungal phosphoinositide-dependent kinase 1 (PDK-1) or a homolog thereof. Inhibition of the fungal PDK-1 or homolog thereof results in the treatment or prevention of a fungal infection in the subject. Also provided are compositions comprising an inhibitor of a fungal phosphoinositide-dependent kinase 1 (PDK-1) or a homolog thereof, and a pharmaceutically acceptable carrier. | 05-17-2012 |
20120114670 | METHODS AND COMPOSITIONS RELATED TO SYNERGISTIC RESPONSES TO ONCOGENIC MUTATIONS - Disclosed are compositions and methods related to new targets for cancer treatment. | 05-10-2012 |
20120088985 | METHODS AND SYSTEMS FOR MEASURING AND COMMUNICATING PAIN AND DISTRESS LEVEL - Systems and methods are described for communicating the distress or pain experienced by an infant or a non-communicative patient. The systems and methods can provide an objective quantification of pain and/or distress in conjunction with, e.g., various distressing procedures commonly found in the newborn intensive care unit (NICU). The systems may include a processor in communication with a distress level input device and a display configured to provide a representation of a pain or distress score calculated in the processor. The processor may include executable code to translate data from the distress level input into the distress score. | 04-12-2012 |
20120070886 | MICROFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE MICROFLUIDIC DEVICE - A microfluidic device having a substrate with an array of curvilinear cavities. The substrate of the microfluidic device is preferably fabricated of a polymer such as polydimethylsiloxane (PDMS). The microfluidic device is manufactured using a gas expansion molding (GEM) technique. | 03-22-2012 |
20120067855 | FEMTOSECOND LASER PULSE SURFACE STRUCTURING METHODS AND MATERIALS RESULTING THEREFROM - Embodiments of the present invention are generally directed to materials processing methods using femtosecond duration laser pulses, and to the altered materials obtained by such methods. The resulting nanostructured (with or without macro- and micro-structuring) materials have a variety of applications, including, for example, aesthetic applications for jewelry or ornamentation; biomedical applications related to biocompatibility; catalysis applications; and modification of, for example, the optical and hydrophilic properties of materials including selective coloring. | 03-22-2012 |
20120065136 | RECOMBINANT FACTOR VIII HAVING ENHANCED STABILITY FOLLOWING MUTATION AT THE A1-C2 DOMAIN INTERFACE - The invention relates to a recombinant factor VIII that includes one or more mutations at an interface of A1 and C2 domains of recombinant factor VIII. The one or more mutations include substitution of one or more amino acid residues with either a cysteine or an amino acid residue having a higher hydrophobicity. This results in enhanced stability of factor VIII. Methods for making the recombinant factor VIII, pharmaceutical compositions containing the recombinant factor VIII, and use of the recombinant factor VIII for treating hemophilia A are also disclosed. | 03-15-2012 |
20120062979 | DIGITAL BINARY MEMS WAVEFRONT CONTROL - A phase screen, i.e., an opto-electronic device that can convert a distorted incoming optical wavefront into a plane wave or, conversely, transform a plane wave into a prescribed varying output wavefront. Binary all-digital MEMS interferometer configurations that can be used to create controlled and arbitrary optical wavefront using only 0,1 amplitude changes followed by differential propagation distances to convert these amplitude variations into controllable and/or continuous phase variations. Clustered pixel notions, such as Floyd-Steinberg, Stucki or other algorithms useful in digital half-tone printing, are simultaneously employed to create controllable grey-level variations as well as continuous phase variations. Desired grey-levels can be obtained wherein each pixel is formed by, e.g., a 3×3 or 5×5 cluster of mirrors. Both the filling-in of the outputs of the binary mirror (0,1) and the grey-levels are accomplished simply by spatial averaging over a short propagation distance. | 03-15-2012 |
20120059439 | ABERRATION CONTROL BY CORNEAL COLLAGEN CROSSLINKING COMBINED WITH BEAM-SHAPING TECHNIQUE - Corneal collagen crosslinking is used to alter a characteristic of the cornea, such as thickness or refractive index, to correct wavefront aberrations, including higher-order aberrations. A scanning laser or the like is used to perform the corneal collagen crosslinking by locally altering the optical path length (thickness, refractive index, or both). | 03-08-2012 |
20120058950 | DETECTION OF NEUROPEPTIDES ASSOCIATED WITH PELVIC PAIN DISORDERS AND USES THEREOF - Diagnostic assessment and therapeutic treatment of pelvic pain disorders, including bladder disorders, bowel disorders, and/or reproductive tissue or organ disorders that are characterized by increased expression of the neuropeptides CGRP and/or PACAP. Additionally, applicants have developed a transgenic non-human model for pelvic pain disorders, where the transgenic animal expresses in bladder sensory neurons a recombinant neuropeptide implicated in the pelvic pain disorder. | 03-08-2012 |
20120045163 | OPTICAL CIRCUIT APPARATUS, METHOD, AND APPLICATION - A new photonic integrated circuit in the form of an optical pulse-train generator utilizes a time-interleaved architecture. The circuit can generate multiple optical pulses sequentially from a single trigger pulse, with the timing and amplitude of each pulse determined by circuit design. The circuit has application in optical arbitrary waveform generation and ultrafast electro-optic modulation. | 02-23-2012 |
20120041289 | SYSTEM AND METHOD FOR STIMULATION OF BIOLOGIC SIGNALS IN A BIO-ELECTRO-PHYSIOLOGIC MATRIX - An implantable device for monitoring physiological changes in an organism is disclosed. The device includes a matrix positioned proximate a biological material of the organism, an irradiation device associated with the matrix for exposing the biological material to radiation, and a sensor device associated with the matrix for detecting a response of the biological material to the irradiation. The response can be used to remotely detect a characteristic of the biological material. | 02-16-2012 |