University of Manitoba Patent applications |
Patent application number | Title | Published |
20150313988 | ARTERIVIRUS - The present invention relates to replication-competent Arteriviruses having a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2, to their use as a medicament, their use as a vaccine and in prophylaxis, to vaccines comprising such Arteriviruses and to Arteriviral PLP2-ubiquitin complexes. | 11-05-2015 |
20150118235 | MeCP2 ISOFORM-SPECIFIC ANTIBODY FOR DETECTION OF ENDOGENOUS EXPRESSION OF MeCP2E1 - An antibody that binds a MeCP2E1 isoform of MeCP2 protein, wherein the antibody comprises a region comprising the amino acid sequence of SEQ ID NO:4. A method for detecting and/or monitoring a disease or a disorder caused by an over-expression or an under-expression of a MeCP2E1 isoform of MeCP2 protein, comprising the steps of: (i) obtaining a first sample from a mammalian subject; (ii) contacting the first sample with the anti-MeCP2E1antibody; (iii) removing unbound antibody from the sample; (iv) conducting an immunoassay on the first sample to determine a first value for expression of the MeCP2E1 isoform; (v) comparing the first value to a reference value for expression of the MeCP2E1 isoform in healthy mammalian subjects; wherein a deviation of the first value from the reference value indicates the presence of a disease or a disorder caused by an over-expression or an under-expression of the MeCP2E1 isoform. | 04-30-2015 |
20150118179 | BIOCIDAL COMPOUNDS AND METHODS FOR USING SAME - Biocidally active cationic analogs of N-halamine having two biocidally active groups covalently bonded together in a single molecule and having general Formula (I). Compounds of Formula (I), and precursors thereof, can be in solution form immobilized onto a substrate via physical coating or covalent chemical bonding to functionalize surfaces or added into materials as additives so as to render them biocidal. The biocidal solutions and substrates comprising the compounds or precursors of the present invention can then be used to inactivate pathogenic microorganisms. N-halamine-L-QUAT (I) wherein: the N-halamine may be a cyclic or acyclic N-halamine; L is C | 04-30-2015 |
20150091693 | REUSABLE ELECTRONIC SEAL - A container including a reusable electronic seal, as well as a system and method for using the electronic seal are described. The container includes a closure member configured to detachably affix to a portion of the container, thereby sealing the container. In response to the closure member sealing the container, a signal generating component generates an electronic signal and transmits the electronic signal to a processing circuit operably connected to the signal generating component. The processing circuit includes a processing device configured to generate a unique code when the closure member is manipulated to open or close the container and an output device operably connected to the processing device and configured to output the unique code. The unique code is updated each time the container is opened, thereby providing a recipient with a way to determine whether the container has been opened during delivery. | 04-02-2015 |
20140330095 | SYSTEM AND METHODS FOR ESTIMATING RESPIRATORY AIRFLOW - A system and methods for screening patients suspected of obstructive sleep apnea. The system includes a sound detection device configured for detecting tracheal respiratory sound signals of a patient and a Sao | 11-06-2014 |
20140328906 | Methods of Treating Impaired Glucose Metabolism via Administration of Algal Biomass - The invention is directed to methods of using | 11-06-2014 |
20140304316 | True Random Number Generator Using GPU and Signal Processing Techniques - A true random number generator (TRNG) uses sources of uncertainty found within graphics processing units (GPUs) together with signal processing techniques, for example histogram equalization, to obtain maximum entropy. | 10-09-2014 |
20140218230 | IMAGING USING PROBES - Methods and systems may image an object of interest using one or more probes. More specifically, such exemplary methods and systems may deliver electromagnetic energy (e.g., microwave energy) using a transmitting antenna to the object while activating a probe to interact with the scattered field and sampling the resulting scattered field using one or more receiving antennas. The sampled electromagnetic energy may then be used to reconstruct an image of the object. | 08-07-2014 |
20140203180 | SCINTILLATION DETECTOR WITH ACTIVE LIGHT GUIDE - A scintillation detector array includes a scintillator array comprising a plurality of scintillator elements, a photodetector array comprising a plurality of photodetector elements, an active light guide separating the scintillator array from the photodetector array. The active light guide formed of a scintillator material having different emission properties than the plurality of scintillator elements. | 07-24-2014 |
20140171674 | NUTRITIONAL COMPOSITIONS COMPRISING HIGH OLEIC ACID CANOLA OIL - A dietary regimen for mitigating cardiovascular disease risk in a subject, the regimen comprising consumption of at least one of a functional food composition comprising high oleic canola oil, a dietary supplement comprising high oleic canola oil, and a nutraceutical composition comprising high oleic canola oil, whereby the subject consumes at least 14 mg/100 g of body weight every 24-hour diurnal period. | 06-19-2014 |
20140161748 | METHODS FOR TREATING SUN-EXPOSED SKIN - The present invention includes methods for treating sun-exposed skin, such as treating photoaging and treating skin cancer. Also included are methods for altering a cell's response to ultraviolet radiation. The methods include administration of quetiapine or an analog thereof or a pharmaceutically acceptable salt, solvate, or prodrug thereof. | 06-12-2014 |
20140142452 | ACOUSTIC SYSTEM AND METHODOLOGY FOR IDENTIFYING THE RISK OF OBSTRUCTIVE SLEEP APNEA DURING WAKEFULNESS - Disclosed are a system and methods for screening a patient for obstructive sleep apnea using features of tracheal breath sounds obtained from the patient during wakefulness. | 05-22-2014 |
20140107576 | APPARATUS FOR LEFT-SIDE INSTALLATION OF TUNNELED VASCULAR CATHETERS - An apparatus for installation of a tunneled vascular catheter into a patient's right atrium from the left side of their upper body. The apparatus comprises a dilator and a peel-away sheath. The dilator has a distal end portion and a proximal end portion interconnected by a shaft portion, with a lumen extending therethrough. The distal end portion is curved about 1° to about 3° from the longitudinal axis of the shaft portion. The end of the proximal end portion is provided with a flange. The total length of the dilator is about 3 cm to about 6 cm. The distal end of the peel-away sheath is provided a flange for contacting the flange at the end of the proximal end portion of the dilator. The length of the peel-away sheath is about 2.5 cm to about 4.5 cm. | 04-17-2014 |
20140066360 | METHODS FOR USING SEMAPHORIN POLYPEPTIDES - The present invention provides uses and methods of using a sema3E polypeptide and a sema3e polynucleotide encoding a sema3E polypeptide. The methods include decreasing airway remodeling in a subject, treating asthma in a subject, treating a subject having, or at risk of having, acute asthma, and reducing inflammation of a subject's airway. The methods also include evaluating treatment options for a subject having asthma and diagnosing whether a subject has asthma. | 03-06-2014 |
20130322709 | USER IDENTITY DETECTION ON INTERACTIVE SURFACES - Technologies are generally provided for customizing operational aspects of a computing system associated with an interactive surface based on determining user identity through detection of one or more user identity attributes on the interactive surface. User identity attributes such as a finger orientation, a finger weight/pressure, a separation between fingers, a finger length, an arm orientation, a handedness, a posture, a DNA, or similar unique features of a user may be detected through an input device associated/integrated with the interactive surface, for example, by employing a camera-based Frustrated Total Internal Reflection (FTIR) system for capturing finger orientation through infrared light reflection, an overhead camera, or through Diffuse Illumination. Multiple attributes may be used to increase a confidence level in user identity determination in synchronous or asynchronous shared use of the interactive surface. | 12-05-2013 |
20130318644 | METHODS FOR TREATING DISORDERS THAT INVOLVE IMMUNOGLOBULIN A - Provided herein are FDC-SP polypeptides and methods of using such polypeptides. Methods include, but are not limited to, altering IgA concentration in a subject, treating a subject having signs of a disorder that includes excessive IgA production, identifying a compound that decreases the concentration of IgA in an animal, and identifying a compound that treats a condition associated with increased levels of IgA. Also provided herein is an animal that has decreased expression of an endogenous FDC-SP coding sequence. The animal may develop pathophysiological features of IgA nephropathy, and/or may display increased IgA in serum, saliva, bronchoalveolar lavage fluid, or a combination thereof; increased IgA expressing B lymphocytes in circulation, lymphoid tissue, or a combination thereof; or increased IgA production in vitro by isolated B lymphocytes | 11-28-2013 |
20130316963 | INNATE DEFENCE REGULATORY PEPTIDE COMPOSITIONS FOR TREATMENT OF ARTHRITIS - A composition for preventing or treating inflammatory arthritis wherein the composition comprises an innate defence regulatory peptide named IDR-1002, said peptide comprising an amino acid sequence listing of VQRWLIVWRIRK, and/or a derivative thereof and/or an analog thereof. Use of the IDR-1002 peptide and/or a derivative thereof and/or an analog or a composition comprising the peptide and/or a derivative and/or analog to modulate the expression and/or function of an inflammatory cytokine and/or a matrix metallopeptidase-3 and/or a cell-signalling pathway. | 11-28-2013 |
20130309695 | METHODS OF DIAGNOSING ASTHMA - A method of detecting a risk for or presence of asthma in a subject. The method comprises obtaining a biological sample comprising human airway smooth muscle cells from a subject and testing the biological sample for the presence of a pentraxin-3 (PTX3) polypeptide. The presence and/or quantity of PTX3 polypeptide in the biological sample correlates with the risk for or presence of asthma in the subject. | 11-21-2013 |
20130296783 | METHOD AND APPARATUS FOR RETROPERFUSION - The present invention relates to apparatus for retroperfusion of tissues and organs. The apparatus comprises a catheter with a proximal end for engaging a supply of the fluid medium, and a distal end having an expandable-contractible chamber for installation into suitable vessels or organs. The expandable-contractible chamber comprises a conduit element having a fluid-filled hollow wall defining a lumen. The conduit element has a first deformable inner-facing section approximate a proximal end of the conduit and a second deformable inner-facing section approximate a distal end of the conduit element. Controlled application of a pressure at a proximal end of the conduit element causes deformation of the conduit into the lumen at its distal end thereby occluding the flow of fluid medium through the catheter. Controlled release of the pressure releases deformation of the fluid-filled conduit at its distal end thereby unblocking the flow of the fluid medium through the catheter. | 11-07-2013 |
20130288323 | MICROBIAL PRODUCTION OF POLYHYDROXYALKANOATES - A process for producing medium-chain-length 3-hydroxyalkanoic acids in a liquid medium, the process comprising: (i) intermixing a liquid culture medium and a microbial inoculum comprising a pure culture of a | 10-31-2013 |
20130269065 | BLACKLEG RESISTANCE GENE - Embodiments of the present invention relate to blackleg resistance genes named BLMR1 and BLMR2. Other embodiments of the present invention relate to primers, vectors, DNA, RNA, proteins, cells, seeds, tissues, plants, methods, processes, and uses relating to said gene sequences. | 10-10-2013 |
20130267506 | THERAPEUTIC COMPOSITIONS FOR DIABETIC SYMMETRICAL POLYNEUROPATHY - Compositions for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof, the compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog. | 10-10-2013 |
20130253357 | SYSTEM AND METHODS OF ACOUSTICAL SCREENING FOR OBSTRUCTIVE SLEEP APNEA DURING WAKEFULNESS - A system and methods using tracheal sound intensity variations to screen patients suspected of obstructive sleep apnea during wakefulness. The system includes a mechanism positioning the patient and a sound input device attached to a recording device to receive breathing sound signals. A signal conditioning component amplifies and filters the breathing sound signals, and an analog to digital component digitizes the signals. A detecting component detects onsets of respiratory phases, and a separating component separates inspiratory sound signals and expiratory sound signals from the breathing sound signals. A segmenting component segments the inspiratory and expiratory phase signals into a short duration of overlapping windows, and a collection characteristic extraction component obtains characteristics from each window. A calculation component performs statistical analysis to reduce the number of significant characteristics and classify the patient as OSA or non-OSA and predicts severity of the OSA as one of mild, moderate and severe. | 09-26-2013 |
20130244447 | OXIDATION OF METALLIC FILMS - Methods for the aqueous oxidation of metallic films are described. For example, a film of hafnium metal on a silicon substrate can be oxidized to hafnium dioxide using hot deionized water. Methods for fabricating electrical components such as capacitors and field effect transistors using the oxidized metallic films are also described. For example, capacitors having a hafnium dioxide dielectric layer can be fabricated. | 09-19-2013 |
20130196922 | BNIP3 ISOFORMS AND METHODS OF USE - The present invention provides isolated splice variants of Bnip3 and isolated polynucleotides encoding the splice variants. Also provided are isolated polypeptides present at the carboxy-terminus of Bnip3 splice variants, and antibody that specifically binds Bnip3 splice variants and/or the carboxy-terminus of Bnip3 splice variants. The present invention further provides methods of altering cellular apoptosis, cellular necrosis, cellular autophagy, or the combination thereof. For instance, the methods may include changing the amount of a Bnip3 splice variant or a carboxy-terminal region of a Bnip3 splice variant in a cell. Also provided herein are methods for determining whether death of cells in a tissue can be altered, methods for evaluating treatment options for a subject, and methods for identifying a compound that alters the amount or activity of a Bnip3 splice variant in a cell. | 08-01-2013 |
20130123201 | MODULATION OF CYTOKINE-INDUCED CHRONIC INFLAMMATORY RESPONSES - A composition for treatment of a chronic inflammation condition or an autoimmune disorder wherein the composition comprises a therapeutically effective amount of a polypeptide molecule comprising an amino acid sequence that shares at least 80% sequence identity with an amino acid sequence selected from SEQ ID NO: 21, SEQ ID NO: 22, SEQ ID NO 23, and SEQ ID NO: 23. A composition for treatment of a chronic inflammation condition or an autoimmune disorder wherein the composition comprises a therapeutically effective amount of an analog of a LL-37 peptide molecule. A composition for treatment of a chronic inflammation condition or an autoimmune disorder wherein the composition comprises a therapeutically effective amount of an exogenous agonist for increasing cellular production and/or cellular activation and/or cellular expression of a LL-37 peptide. Use of one or more of the compositions for treatment of a chronic inflammation condition or an autoimmune disorder. | 05-16-2013 |
20130123198 | MODULATION OF SCLERAXIS USING A DOMINANT NEGATIVE SCLERAXIS MUTANT WITH A BASIC DNA-BINDING DOMAIN DELETION - Compositions and kits for modulating expression of scleraxis and/or collagen synthesis in mammalian cells and tissues. The compositions and kits comprise a protein comprising an amino acid sequence that shares at least 75% homology with SEQ ID NO:11. Proteins comprising amino acid sequences that share at least 75% homology with SEQ ID NO: 11 are expressed by mutants of scleraxis gene wherein a nucleotide sequence comprising a basic DNA binding domain has been deleted. Such mutants are exemplified by basic domain deletion ScxΔBD mutants that comprise nucleotide sequences sharing at least 75% homology with SEQ ID NO:8 or SEQ ID NO: 10. Methods for modulating fibrosis in a subject comprising administration of a composition comprising at least one physiologically effective dosage of a protein comprising a polypeptide molecule comprising an amino acid sequence that shares at least 75% homology with SEQ ID NO: 11. | 05-16-2013 |
20130106447 | DETECTION OF REINFORCEMENT METAL CORROSION | 05-02-2013 |
20130094030 | METHODS AND SYSTEMS FOR USE IN IMAGING USING INTERFEROMETRY - Methods and/or systems are disclosed herein for use in imaging an object including using interferometry while modifying at least one characteristic of the object (e.g., refractive index of the object). | 04-18-2013 |
20130090862 | METHODS AND SYSTEMS FOR ANALYSIS OF PEPTIDE SAMPLE STREAMS USING TANDEM MASS SPECTROSCOPY - The present disclosure relates to methods and systems for analyzing a peptide sample stream from a chromatography column using tandem mass spectroscopy. Analysis of the sample stream during a first time interval is performed in order to identify peptides, such as tryptic peptides, that are contained in the sample stream. Database searching is then performed to identify one or more protein sequences that contain the identified peptide sequence and to identify associated peptide sequences that are contained in the protein sequence that differ from the peptide sequence. The retention time of associated peptides is estimated based on the hydrophobicity of the predicted peptides and by spiking the sample with standard peptides. Information on associated peptides can then be used to configure the mass spectrometer during a second time interval to detect or ignore ions that correspond to the associated peptides. | 04-11-2013 |
20130053337 | GUANIDINYLATED AMINOGLYCOSIDE-LIPID CONJUGATES - Guanadinylated aminoglycoside-lipid conjugates are prepared. Such conjugates may comprise an aminoglycoside such as an aminoglyucoside antibiotic like neomycin or kanamycin, at least one guanidino group attached to a primary or secondary carbon atom of the aminoglyucoside group and at least one lipid group attached through a bond or a linker to a branched carbon atom of the aminoglycoside. These conjugates exhibit improve antibacterial activity and may be used in conjunction with another antibiotic. | 02-28-2013 |
20120322884 | EPINEPHRINE NANOPARTICLES, METHODS OF FABRICATION THEREOF, AND METHODS FOR USE THEREOF FOR TREATMENT OF CONDITIONS RESPONSIVE TO EPINEPHRINE - The invention provides a composition including epinephrine nanoparticles and methods for therapeutic use of the composition in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions. | 12-20-2012 |
20120237894 | DENTAL APPARATUS - A dental apparatus for removing fluid from a patient's mouth during a dental procedure, the dental apparatus includes an intraoral tip having a wall defining a cavity, the wall having a plurality of apertures and at least one opening, the apertures being distributed over the wall; and a hollow tube coupled to the intraoral tip, the hollow tube for connecting the opening of the intraoral tip to a suction device. The intraoral tip is continuously within the patient's mouth during the dental procedure and the dental apparatus removes fluid from the patient's mouth through the apertures of said intraoral tip. In one embodiment, the dental apparatus further includes a valve for modulating the rate of fluid removal from the patient's mouth. In another embodiment, the dental apparatus further includes a fastener for securing the intraoral tip within the patient's mouth. | 09-20-2012 |
20120202039 | IN SITU POLYMERIZATION OF CONDUCTING POLY(3,4-ETHYLENEDIOXYTHIOPHENE) - Conducting poly(3,4-ethylenedioxythiophene) films are prepared upon solvent removal using an easily processable metastable solution of monomer and oxidant. This method allows the casting and spin-coating of films on conducting as well as insulating substrates with conductivities as well as optical and redox properties similar to those reported for chemically (vapor phase) and electrochemically synthesized thin films. Morphological characterization of spin coated poly(3,4-ethylenedioxythiophene) films suggest that they are smooth, uniform and free of pinholes on the micron scale. These films show conductivities in the range of 0.03 to 5 S/cm. | 08-09-2012 |
20120168607 | IMAGING SYSTEM AND METHOD USING SPATIALLY SEPARATED RADIATED FIELDS - Methods and systems for use in imaging an imaging domain that spatially separate a scattered field and reconstruct an image based on the spatially separated scattered field (e.g., for use in microwave imaging applications including tumor detection in human tissue, etc.). | 07-05-2012 |
20120115774 | ANTIMICROBIAL CATIONIC LIPO-BETA-PEPTIDES - In some aspects, the present invention provides ultrashort lipopeptides which feature β-amino acids or β-peptides and demonstrate antimicrobial activity. Accordingly, some aspects of the present invention provide lipopeptide compositions and methods of making and using the compositions as antimicrobial agents. | 05-10-2012 |
20110315932 | SELF-DOPED POLYANILINE NANOPARTICLE DISPERSIONS BASED ON BORONIC ACID-PHOSPHATE COMPLEXATION - Poly(anilineboronic acid)/phosphate nanoparticle dispersions are produced in high yields using the reactivity of the boronic acid moiety with phosphate in the presence of fluoride. The poly(anilineboronic acid)/phosphate dispersions have been characterized using spectroscopic, microscopic and electrochemical techniques. According to | 12-29-2011 |
20110230434 | USE OF S-ADENOSYLMETHIONINE, VITAMIN E, AND VITAMIN C FOR THE TREATMENT OF OXIDATIVE LIVER INJURY OR INSULIN RESISTANCE - The present invention provides antioxidant compositions comprising S-adenosylmethionine (SAMe), vitamin E and vitamin C and uses thereof for the treatment of liver injury and insulin resistance. | 09-22-2011 |
20110227586 | MICROWAVE TOMOGRAPHY SYSTEMS AND METHODS - Methods and/or systems are disclosed herein for use in imaging an object with microwave tomography using a plurality of different boundary conditions. | 09-22-2011 |
20110219858 | COMPOSITION FOR USE AS A PEPTIDE RETENTION STANDARD AND A METHOD OF PREDICTING PEPTIDE HYDROPHOBICITY IN LIQUID CHROMATOGRAPHY - A composition comprising synthetic peptides for use as a peptide retention standard in liquid chromatography applications is disclosed Said synthetic peptides have a broad range of hydrophobicity while maintaining low variation in their molecular weights The synthetic peptides disclosed consist of the ammo acid sequences LGGGGGGDGSR, LGGGGGGDFR, LLGGGGDFG, LLLGGDFR, LLLLDFR, LLLLLDFR A method of predicting the hydrophobicity of an unknown peptide in liquid chromatography using a composition of peptide retention standards and a method of developing a Universal Hydrophobicity Index (UHI) for the measurement of peptide hydrophobicity in liquid chromatography are also described | 09-15-2011 |
20110178037 | HYDROPHOBICALLY ENHANCED AMINOGLYCOSIDES - Hydrophobically enhanced aminoglycosides have been prepared and shown to be effective antibacterial agents. These agents may be used in the treatment or prevention of various bacterial infections. Methods of preparing these agents also permit facile synthetic access. Formula (I). | 07-21-2011 |
20110104972 | PROTECTIVE BARRIER HAVING SELF-DECONTAMINATING PROPERTIES - A protective material includes a porous substrate having cross-linked self-decontaminating polymer grafted thereon, the cross-linked self-decontaminating polymer having been converted after grafting to activate self-decontaminating function. The cross-linked self-decontaminating polymer provides the protective material with reversible swelling ability to block the porous substrate when the protective barrier is contacted by liquids. | 05-05-2011 |
20110046907 | SYSTEM AND METHODS OF IMPROVED TOMOGRAPHY IMAGING - The present invention is a system and methods of improved tomography imaging such as microwave tomography (MWT). An improved inversion technique surrounds the imaging region with an electrically conducting surface to create field distortions producing an improved tomographic image. The improved inversion technique of the present invention creates a new physical situation for proposed imaging systems. | 02-24-2011 |
20110045139 | FERMENTED SAUSAGE AND METHODS OF MAKING SAME - The present invention provides methods for producing a fermented sausage, such as a semi-dry or dry fermented sausage. The methods include adding to a sausage batter a processed mustard, where the processed mustard may include characteristics chosen from a total phenolic content of at least 21 mg FAE/gram processed mustard, an antioxidant capacity of at least 900 micromol/100 grams processed mustard, no detectable myrosinase activity, and a combination thereof. The present invention also provides fermented sausage, such as a dry fermented sausage, that includes vegetable protein. The vegetable protein may be at a level of at least 0.01% (wt/wt). | 02-24-2011 |
20110014174 | Lysozyme, A Novel Vasodilator of Sepsis that can be inhibited by a Peroxidase and Hydroxyl Radical Scavengers - A method of reducing a vasodilatory response comprising administering to an individual in need of such treatment an effective amount of a guanylate cyclase pathway inhibitor selected from the group consisting of methylene blue, ODQ, LY83583 and a protein kinase G inhibitor or an H | 01-20-2011 |
20100261639 | TRIAZOLE-BASED AMINOGLYCOSIDE-PEPTIDE CONJUGATES AND METHODS OF USE - Aminoglycoside-amino acid and -peptide conjugates comprising a triazolyl linker are provided along with efficient methods of their preparation. The aminoglycoside may be an aminoglycoside antibiotic. Conjugates comprising an aminoglycoside antibiotic may exhibit antimicrobial activities against Gram-positive and/or Gram-negative strains and display significantly enhanced activity against multi-drug resistant MRSA and MRSE when compared to their unconjugated aminoglycoside antibiotic counterparts. | 10-14-2010 |
20100253417 | Conducting Polymer for Electronic, Photonic and Electromechanical Systems - The present invention concerns doped organic semiconductors composites. In certain aspects, organic polymers are doped with large anions, such as DBS | 10-07-2010 |
20100195008 | PLANAR NEMATIC LIQUID CRYSTAL CELLS DOPED WITH NANOPARTICLES AND METHODS OF INDUCING A FREEDERICKSZ TRANSITION - Nematic liquid crystal cells with positive dielectric anisotropy that include colloidal suspensions having nanoclusters are provided as well as methods of inducing Freedericksz transitions therein and methods of controlling the alignment of a liquid crystal. | 08-05-2010 |
20100183557 | PTRA GENE AND USES THEREOF - An isolated nucleic acid molecule comprising a nucleotide sequence set forth in SEQ ID NO: 1, said nucleotide sequence encoding a protein inhibitory to | 07-22-2010 |
20100144660 | USE OF N,N-DIETHYL-2-[-4-(PHENYLMETHYL)-PHENOXY]ETHANAMINE MONOHYDROCHLORIDE (DPPE) IN CANCER THEREAPY - The present invention provides for the use of N,N-diethyl-2-[-4-(phenylmethyl)-phenoxy]ethanamine monohydrochloride (DPPE) in cancer therapy. DPPE is used in the treatment of patients having, or suspected of having, an aggressive cancer. The present invention further provides for the use of DPPE in the treatment of a patient suspected of having an existing cancer, wherein the use follows a surgery for treatment of a primary cancer that is estrogen-receptor negative. Also provided are pharmaceutical compositions comprising DPPE for use in the treatment of patients having, or suspected of having, an aggressive cancer and pharmaceutical kits comprising such compositions. | 06-10-2010 |
20100123073 | ELECTRON CAPTURE DISSOCIATION IN A MASS SPECTROMETER - A mass spectrometer, that may be a time of flight mass spectrometer, has a source of ions having desired characteristics. The mass spectrometer section includes a modulator and first and second apertures on opposite sides of the modulator, with the first aperture providing a connection to the source of ions. A cell is connected to the modulator of the time-of flight mass spectrometer section by the second aperture, whereby, in use, ions from the source of ions can pass through the first aperture, the modulator and the second aperture into the cell, for capture of electrons or collision with a gas, to generate daughter ions, and the daughter ions are passed back into the time-of-flight or other mass spectrometer section for analysis. | 05-20-2010 |
20090324565 | A Colicinogenic Strain of E. Coli - Described herein is the isolation of colicin-producing strains of | 12-31-2009 |
20090305267 | MICROBIAL MARKERS OF INFLAMMATORY BOWEL DISEASE - The present invention relates to bacterial serine protease autotransporter (SPATE) and Antigen 43 (Ag43) and their various uses relating to inflammatory bowel disease (IBD), specifically in the diagnosis of IBD and the screening of potential agent for treating IBD. The invention also relates to methods for cultivating and identifying enteric microbes. | 12-10-2009 |
20090299031 | Metastable Reaction Mixtures For The In Situ Polymerization Of Conducting Polymers - Conducting polythiophene films are produced by the oxidation of bithiophene or terthiophene monomers using phosphomolybdic acid, wherein the reagents are first combined to form a metastable solution, the solution is then cast as a film, and polymerisation ultimately initiated by evaporation of the solvent The equivalent formation of polypyrrole via the oxidation of pyrrole using phosphomolybdic acid has been previously demonstrated, but this approach cannot be applied directly to thiophene, which has too high an oxidation potential Bithiophene and terthiophene have lower oxidation potentials, close to that of pyrrole This work suggests the previously demonstrated method is suitable for general application, requiring only the proper matching of monomer and oxidant redox potentials, and the selection of a suitable solvent and starting concentration Smooth, spin-coated polythiophene films having thicknesses of 100 to 200 run and conductivities in the range 0.2 to 0.3 S-cm | 12-03-2009 |
20090270311 | TREATMENT OF INSULIN RESISTANCE BY MODULATING SOMATOSTATIN USING SOMATOSTATIN RECEPTOR ANTAGONISTS - The present invention provides the use of somatostatin antagonists for treating and preventing HISS-dependent insulin resistance and hemorrhage induced insulin resistance. The present further provides pharmaceutical compositions comprising a somatostatin antagonist and a pharmaceutically acceptable liver targeting compound. | 10-29-2009 |
20090093010 | Method of Detecting Kidney Dysfunction - Methods and kits for monitoring kidney function, and detecting kidney dysfunction and transplant related disease and rejection are disclosed. The method involves analyzing a sample, such as a urine sample, containing protein from an animal for fragments of β2-microglobulin, wherein the presence of specific β2-microglobulin fragments is indicative of kidney dysfunction and transplant rejection. In another embodiement, urine samples from an animal are tested for protease activity, such as cathepsin D or napsin A, wherein increased protease activity compared to a control sample is indicative of kidney dysfunction. | 04-09-2009 |
20080275213 | Synthesis of Carbohydrate-Templated Amino Acids and Methods of Using Same - The present invention generally relates to tetrahydropyranyl-derivatized amino acids, their syntheses and their incorporation into peptides and peptidomimetics. The tetrahydropyran moiety constrains the side chain of an amino acid, thereby providing a molecule that may act as a sugar- or amino acid-mimetic as well as a scaffold for combinatorial synthesis. | 11-06-2008 |
20080262002 | Use of S-Adenosylmethionine, Vitamin E, and Vitamin C for the Treatment of Oxidative Liver Injury or Insulin Resistance - The present invention provides antioxidant compositions comprising S-adenosylmethionine (SAMe), vitamin E and vitamin C and uses thereof for the treatment of liver injury and insulin resistance. | 10-23-2008 |
20080255062 | AXON REGENERATION FROM ADULT SENSORY NEURONS - A method for rapidly screening small molecules to identify small molecules that stimulate axon regeneration and outgrowth from adult sensory neurons. The method generally comprises preparing a purified individualized dorsal root ganglia cell suspension (DRG), coating well surfaces of a suitably prepared multi-well microplate with the DRG, then dispensing dosages of selected small molecules into selected wells. The microplates are incubated under sterile conditions at about 37° C. for at least 24 hours. The DRG suspension in each well is then morphometrically assessed to assess the extent of axon regeneration and outgrowth that occurred, and the effects of the selected small molecules are determined by comparison to control treatments. The method is suitable for screening chemically derived small molecules and biologically derived small molecules. | 10-16-2008 |
20080235828 | PLANT PROTEINS HAVING AN ABSCISIC ACID BINDING SITE AND METHODS OF USE - Compositions and methods for modifying the sensitivity to abscisic acid, of seeds and vegetative tissues of plants. The compositions comprise novel nucleotide molecules configured for expressing an abscisic acid-binding protein, i.e., ABAP1, comprising an amino acid sequence set forth in SEQ ID NO: 10. The methods comprise the steps of constructing a nucleotide molecule by fusing a nucleotide coding sequence set forth in SEQ ID NO: 9 with a regulatory nucleotide sequence selected for over-expression or for under-expression of the coding sequence, stably introducing the nucleotide molecule into the genome of a recipient cell from a seed-producing plant, culturing the recipient cell into a whole recipient plant and then further culturing the recipient plant to produce mature recipient seeds, and harvesting the recipient seeds. The recipient seeds and whole plants produced therefrom have modified sensitivities to ABA thereby enabling regulation of germination, physiological function and plant productivity. | 09-25-2008 |