University of Florida Research Foundation Inc. Patent applications |
Patent application number | Title | Published |
20160106865 | CAPSID-MODIFIED RAAV VECTORS AND METHODS OF USE - Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors. | 04-21-2016 |
20160106767 | USE OF PKC-IOTA INHIBITORS FOR THE TREATMENT OF BREAST CANCER - The subject invention pertains to uses of PKC-iota inhibitors for treatment of breast cancer. In one embodiment, the subject invention provides novel uses of 1H-imidazole-4-carboxamide, 5-amino-1-[2,3 -dihydroxy-4-[(phosphonooxy) methyl]cyclopentyl]-,[1R-(1α, 2β, 3β, 4α)] (ICA-1) and related compounds for treatment of breast cancer. The compounds of the subject invention have potent anti-proliferative effects against human breast cancer cells. The compounds of the subject invention also inhibit the phosphorylation of IKK-α/IKK-β, induce chromatin condensation, and/or induce DNA fragmentation in cancer cells. | 04-21-2016 |
20160102321 | HAIRPIN mRNA ELEMENTS AND METHODS FOR THE REGULATION OF PROTEIN TRANSLATION - The present invention provides novel mRNA elements capable of forming hairpin, double-stranded RNA structures independent of other non-coding RNAs. These mRNAs are stably expressed, lack polyadenylation tails, and allow minimal protein translation except when in the presence of specific proteins. Also provided, are compositions and kits comprising the mRNA element, as well as methods for its use in the regulation of protein translation. Advantageously, the disclosed elements represent a novel tool useful in regulating the expression of a wide variety of proteins of interest. | 04-14-2016 |
20160067240 | NOVEL ALLOSTERIC INHIBITORS OF THYMIDYLATE SYNTHASE - The current invention is directed to a class of compounds that inhibit the function of Thymidylate synthase. Thymidylate synthase inhibition was noted to result in inhibition of tumor cell grow and killing of tumor cells. Thymidylate synthase inhibition is, thus, useful for treatment of various types of cancers, including but not limited to, acute lymphoblatic leukemia (ALL), acute myelogenous leukemia (AML), acute promyelocytic leukemia, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute monocytic leukemia (AMOL), hairy cell leukemia, large cell immunoblastic lymphoma, plasmacytoma, multiple myeloma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, leukemia, brain cancer, lung cancer, central nervous system (CNS) cancer, melanoma, renal cancer, prostate cancer, colon cancer, ovarian cancer and breast cancer. The compounds disclosed herein can be used alone or in combination with other cancer treatment regimens (e.g., radiation therapy and/or other chemotherapeutic agents that are administered to a subject having a tumor, cancer or neoplasia). | 03-10-2016 |
20160028036 | Quantum-Dot Based Hybrid LED Lighting Devices - A white light source is a hybrid organic light emitting diode (OLED) device having an electroluminescent layer including a blue emitting organic phosphor or a combination of a green emitting organic phosphor with a blue emitting phosphor and a conversion layer including photoluminescent quantum dots (QDs) at or near the light exiting face of the hybrid OLED. The | 01-28-2016 |
20160025747 | USE AND TREATMENT OF DI-AMINO ACID REPEAT-CONTAINING PROTEINS ASSOCIATED WITH ALS - Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein. | 01-28-2016 |
20160024178 | COMPOUNDS FOR TREATING NEURODEGENERATIVE PROTEINOPATHIES - This invention relates to compounds (e.g., those delineated herein), pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering modulating compounds or compositions that modulate Aβ, PAMPS and DAMPS. | 01-28-2016 |
20160022645 | DESFERRITHIOCIN POLYETHER ANALOGUES - A relatively non-toxic desazadesferrithiocin analog having the formula: | 01-28-2016 |
20160022157 | Devices and Methods for Monitoring Directional Blood Flow and Pulse Wave Velocity with Photoplethysmography - Provided according to embodiments of the invention are methods of monitoring the direction of blood flow that include processing with a computer photoplethysmography (PPG) signal streams from a sensor array on a body site of the individual to determine the direction and/or velocity of the blood flow at the body site of the individual. In some embodiments, direction of the blood flow at the body site is determined by the phase difference between at least three PPG signal streams from the sensor array, wherein the at least three PPG signal streams are generated from emissions of the at least three emitters. | 01-28-2016 |
20160020476 | OPERATIONAL CONTROL OF FUEL CELLS - Various examples are provided for operational control of fuel cells. In one example, among others, a system for controlling a fuel cell includes a stack temperature controller in cascade with a liquid level controller. The liquid level controller can provide a control output based at least in part upon an indication of a liquid level of a liquid fuel tank and a level reference. The stack temperature controller can provide a fan speed control output based at least in part upon an indication of a stack temperature of the fuel cell and the control output of the liquid level controller. In another example, a system for estimating methanol concentration of a fuel cell system includes a state observer that generates an estimate of the methanol concentration of fuel provided to a direct methanol fuel cell based upon a plurality of states of the fuel cell system. | 01-21-2016 |
20160017012 | DELIVERY OF CARD PROTEIN AS THERAPY FOR OCCULAR INFLAMMATION - The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or ocular inflammation. In an exemplary embodiment, a method is disclosed that involves administering an expression vector that delivers a secretable and cell penetrating CARD to a subject in need of treatment or prevention of age-related macular degeneration or another condition involving macular degeneration or ocular neovascularization. | 01-21-2016 |
20160015664 | Materials and Methods for Improving Lung Function and For Prevention and/or Treatment of Radiation-Induced Lung Complications - The subject invention provides therapeutic compositions and uses thereof for improving pulmonary function. In one embodiment, the therapeutic composition comprises one or more free amino acids selected from lysine, glycine, threonine, valine, tyrosine, aspartic acid, isoleucine, tryptophan, asparagine, and serine; and electrolytes. In one embodiment, the subject invention can be used to prevent or treat long-term lung complications induced by radiation. | 01-21-2016 |
20150372252 | BUCKLED ORGANIC LIGHT EMITTING DIODE FOR LIGHT EXTRACTION WITHOUT BLURRING - A layered organic light emitting diode (OLED) device comprises a buckled structure over a portion of the light emitting face to provide improved light output relative to flat OLED devices. The buckled structure has a fine buckling and a gross buckling, which are quasi-periodic. Embodiments of the invention are directed to a method of producing the OLED device comprising a buckled structure, where a transparent substrate coated with a transparent elastomeric layer has a thin metal layer deposited on a portion of the elastomeric layer at an elevated temperature. Upon cooling the metal layer buckles with the formation of the quasi-periodic buckling. Subsequently the metal layer is oxidized to a metal oxide layer that retains the buckling. An OLED with a buckling structure over a portion of the emitting face is constructed on the metal oxide layer and retains the buckling of the metal oxide layer. | 12-24-2015 |
20150372046 | A NOVEL IR IMAGE SENSOR USING A SOLUTION-PROCESSED PbS PHOTODETECTOR - An image sensor is constructed on a substrate that is a read-out transistor array with a multilayer array of infrared photodetectors formed thereon. The infrared photodetectors include a multiplicity of layers including an infrared transparent electrode distal to the substrate, a counter electrode directly contacting the substrate, and an infrared sensitizing layer that comprises a multiplicity of nanoparticles. The layers can be inorganic or organic materials. In addition to the electrodes and sensitizing layers, the multilayer stack can include a hole-blocking layer, an electron-blocking layer, and an anti-reflective layer. The infrared sensitizing layer can be PbS or PbSe quantum dots. | 12-24-2015 |
20150366883 | METHOD OF TREATING OVARIAN CANCER USING A PKC INHIBITOR - A method of treating ovarian cancer by administering a PKC inhibitor is presented herein. It was found that administering a PKC inhibitor, such as ACPD or ICA-1, to ovarian cancer cells inhibited cancer cell proliferation. | 12-24-2015 |
20150340656 | BUCKLED ORGANIC LIGHT EMITTING DIODE FOR LIGHT EXTRACTION - Embodiments of the invention are directed to a layered organic light emitting diode (OLED) device comprising a buckled structure that provides an improved light output relative to flat OLED devices. The buckled structure has a fine buckling with a quasi-periodicity of 100 to 700 nm and a gross buckling of 10 to 20 μm. Embodiments of the invention are directed to a method of producing the OLED device comprising a buckled structure, where a transparent substrate is coated with a transparent elastomeric layer, upon which a thin metal layer of 20 to 100 nm is deposited at an elevated temperature. Upon cooling to ambient temperature, the metal layer buckles with the formation of a fine buckling with a quasi-periodicity of 100 to 700 nm and a gross buckling of 10 to 20 μm. The metal layer is oxidized to a transparent metal oxide layer with the retention of the buckling. Subsequent steps comprising deposition of at least an anode layer, an electroluminescence layer, and a cathode layer forms an OLED that has a buckling structure resulting from the buckled metal structure formed upon cooling. | 11-26-2015 |
20150340631 | AMBIPOLAR VERTICAL FIELD EFFECT TRANSISTOR - Various examples are provided for ambipolar vertical field effect transistors (VFETs). In one example, among others, an ambipolar VFET includes a gate layer; a source layer that is electrically percolating and perforated; a dielectric layer; a drain layer; and a semiconducting channel layer. The semiconducting channel layer is in contact with at least a portion of the source layer and at least a portion of the dielectric layer and the source layer and the semiconducting channel layer form a gate voltage tunable charge injection barrier. Another example includes an ambipolar vertical field effect transistor including a dielectric surface treatment layer. The semiconducting channel layer is in contact with at least a portion of the source layer and at least a portion of the dielectric surface treatment layer and where the source layer and the semiconducting channel layer form a gate voltage tunable charge injection barrier. | 11-26-2015 |
20150336911 | DESFERRITHIOCIN POLYETHER ANALOGUES - Compounds represented by structural formulas described herein, such as Structural Formula (I): | 11-26-2015 |
20150273398 | ELECTROKINETIC DEWATERING OF PHOSPHATIC CLAY SUSPENSIONS - Various examples are provided for electrokinetic dewatering of e.g., phosphatic clay suspensions. In one example, among others, a system includes a separation chamber including an anode and a cathode extending ends of the separation chamber and a power supply configured to energize the anode and the cathode to establish an electric field. An inlet at one end of the separation chamber can supply a dilute feed suspension and an outlet at another end of the separation chamber can remove supernatant water. The electric field can consolidate solids in the dilute feed suspension. Consolidated solids may be removed by a removal mechanism. In another example, a method includes supplying a dilute feed suspension including suspended solids, establishing an electric field to consolidate solids, and removing supernatant water. | 10-01-2015 |
20150269887 | BRIGHTNESS COMPENSATION IN A DISPLAY - Various examples are provided for brightness compensation in a display. In one example, a method includes identifying an IR voltage drop effect on a pixel supplied by a supply voltage line and generating a brightness signal for the pixel based at least in part on the IR voltage drop effect. In another example, a method includes calculating values of IR voltage drop corresponding to pixels fed by a common supply voltage line and providing a data line signal to each pixel that compensates for the IR voltage drop. In another example, a display device includes a matrix of pixels and a brightness controller configured to determine an IR voltage drop effect on a pixel of the matrix and generate a brightness signal for the pixel based at least in part on the IR voltage drop effect and a temporal average pixel brightness within one refreshing cycle associated with the pixel. | 09-24-2015 |
20150268686 | SOCIAL NETWORKING REDUCING PEAK POWER CONSUMPTION IN SMART GRID - A method of operating a system to reduce peak power consumption of a plurality of users. The method may comprise forming at least one cluster of the plurality of users based on connections within a social network system between the plurality of users, and energy usage patterns of the plurality of users; and scheduling jobs for at least one user within the at least one cluster to reduce peak power used within the at least one cluster. A method of scheduling jobs that consume power for a cluster of users. The cluster may be formed in part based on connections within a social network system. Membership in a cluster may be further based on energy usage patterns. At least one computer-readable storage medium encoded with executable instructions that cause at least one processor to perform a method for forming a cluster and/or scheduling jobs for users within the cluster. | 09-24-2015 |
20150173334 | REINFORCED HYDROGEL LURES AND BAIT - A fishing lure comprises a hydrogel material and at least one water soluble attractant. The fishing lure can be a single hydrogel component or can have a core-shell structure having one or more shells on a core, where the shells and core differ by repeating unit composition and/or by the cross-linking density of the shell and core material, wherein the core is more highly cross-linked than the shells. The hydrogel can be cross-linked ionically, covalently, or physically by phase separation of a block copolymer. The fishing lure displays a loss of attractant during use, but the lure can be reloaded by submerging the lure in a solution of or in neat liquid attractant. When the fishing lure has a core-shell structure, an additional attractant that has low water-solubility, such as a lipid or oil, can be infused into the lure. | 06-25-2015 |
20150147388 | Materials and Methods for Modulating immune Responses - The present invention provides materials and methods for modulating an immune response. In one embodiment, the present invention provides an initial artificial lymph-node homing environment, and a simultaneous, or subsequent, artificial spleen environment leading to the resolution of the activated immune responses. In one specific embodiment, the present invention can be used to prevent and/or treat pathogenic infection, cancer, allergenic reactions, and/or unwanted immune or auto-immune responses. | 05-28-2015 |
20150138621 | INFRARED-MODULATING ELECTROACTIVE DEVICES WITH VISIBLE REGION TRANSPARENCY - An electrochromic cell includes a minimally color changing polymer (MCCP) and a non-color changing polymer (NCCP), where the neutral state or the oxidized state is highly transmissive in the NIR and the oxidized state or the neutral state, respectively, is significantly less transmissive in the NIR. An electrochromic device (ECD) can include the electrochromic cell, or a combination of electrochromic cells. The ECD can be part of a window or a laminate for a window to permit the control of IR transmittance through the window. | 05-21-2015 |
20150133530 | HIGH-TRANSDUCTION-EFFICIENCY RAAV VECTORS, COMPOSITIONS, AND METHODS OF USE - The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the VP3 region. Also provided are rAAV virions comprising the AAV capsid proteins of the present invention, as well as nucleic acid molecules and rAAV vectors encoding the AAV capsid proteins of the present invention. Advantageously, the rAAV vectors and virions of the present invention have improved efficiency in transduction of a variety of cells, tissues and organs of interest, when compared to wild-type rAAV vectors and virions. | 05-14-2015 |
20150126796 | PREVENTION OF SETUP ERRORS IN RADIOTHERAPY - A patient safety system (PSS) ( | 05-07-2015 |
20150118626 | TUBE NOZZLE ELECTROSPINNING - Various examples are provided for tube nozzle electrospinning. In one example, among others, is a system including a nozzle tube with an array of nozzles configured to produce a plurality of electrospun nanofibers and a positioning stage configured to control deposition of the plurality of electrospun nanofibers on a substrate to form a layer of nanofibers. Another example is a method including generating a plurality of electrospun nanofibers from an array of nozzles positioned over a substrate and controlling movement of the substrate to form a layer of electrospun nanofibers. | 04-30-2015 |
20150101609 | Monitoring Positive End Expiratory Pressure With Photoplethysmography - Provided according to embodiments of the invention are methods for monitoring the application of positive end expiratory pressure (PEEP) to an individual. Such methods include isolating a pulsatile arterial component (PAC) signal and a venous impedance component (VIC) signal of a PPG signal obtained from a central source site of the individual; monitoring the PAC signal, the VIC signal, or both, over time; and adjusting the level of PEEP based on the PAC signal, the VIC signal, or both. | 04-16-2015 |
20150088024 | METHODS AND SYSTEMS FOR BRAIN FUNCTION ANALYSIS - Various methods and systems are provided for cerebral diagnosis. In one example, among others, a method includes obtaining EEG signals from sensors positioned on a subject; conditioning data from the EEG signals to remove artifacts; generating a cerebral network model based at least in part upon the conditioned data; determining network features based upon the cerebral network model; and determining a cerebral condition of the subject based at least in part upon the network features. In another example, a method includes determining a recording condition of a positioned EEG sensor and providing an indication of an unacceptable recording condition of the EEG sensor. In another example, a system includes an EEG recording module to acquire signals; a signal conditioning module to condition signal data; a signal analysis module to determine signal features and cerebral network features; and a condition classification module to determine a cerebral condition of the subject. | 03-26-2015 |
20150071961 | SIDEROPHORE CONJUGATE IMMUNOGENIC COMPOSITIONS AND VACCINES - An immunogenic composition comprising a siderophore covalently linked to a pharmaceutically acceptable carrier molecule wherein the antigenicity of the siderophore moiety is sufficient to stimulate an immunologic response to the siderophore when the composition is circulating in the bloodstream of a human or non-human animal and vaccine. | 03-12-2015 |
20150056259 | ENGINEERED PARTICULATE SYSTEMS FOR CONTROLLED RELEASE OF PESTICIDES AND REPELLANTS - Nanoengineered particulate coatings (NPCs) comprise a multiplicity of particulate hosts that are infused with a nanophase comprising a surfactant and at least one guest. The particulate hosts can be clay particles, the surfactant can be a cationic surfactant, and the guest can be an insect repellant. For example, montmorillonite particles infused with hexadecyl trimethyl ammonium bromide and garlic oil form NPCs that may be used to form an emulsion or suspension for spraying on citrus trees to repel Asian Citrus Psyllid. | 02-26-2015 |
20150020149 | ADAPTIVE IDENTITY RIGHTS MANAGEMENT SYSTEM FOR REGULATORY COMPLIANCE AND PRIVACY PROTECTION - Some embodiments are directed to managing transactions in a computer system, which receives information indicating a first node has at least one right with regard to a second node such that the first node is associated with the second node. An identity network is created, based, on the association between the first node and the second node, representing undirected ties between a plurality of nodes, the plurality of nodes including at least the first and second node. Using the identity network, a rights network is created representing directed ties between the plurality of nodes based, at least in part, on the undirected ties of the identity network and the at least one right the first node has with regard to the second node. The rights network is used to determine whether a transaction initiated by the first node is permissible based, at least in part, on the rights network. | 01-15-2015 |
20150010714 | ION BEAM PROCESSING OF SIC FOR FABRICATION OF GRAPHENE STRUCTURES - A method of preparing graphene on a SiC substrate includes bombarding a surface of the SiC substrate with ions and annealing a volume of the SiC substrate at the bombarded surface to promote agglomeration of carbon at the bombarded surface to form one or more layers of graphene at that surface. The ions can be Si, C, or other ions such as Au. The annealing can be carried out using a thermal source of heating or by irradiation with at least one laser beam or other high energy beam. | 01-08-2015 |
20140364384 | MEDICATION ADHERENCE MONITORING SYSTEM - The present invention relates to the detection of markers in exhaled breath, wherein the detection of the presence or absence of the marker(s) in exhaled breath is used to assess various clinical data, including patient adherence in taking the medication and patient enzymatic (metabolic) competence in metabolizing the medication. An embodiment of the invention comprises a parent therapeutic agent labeled with a marker, where upon metabolism (e.g., via enzymatic action) of the therapeutic agent, the marker becomes volatile or semi-volatile and is present in the breath. In certain related embodiments, the marker contain a deuterium label, which is also present in the breath upon metabolism of the therapeutic agent. In another embodiment of the invention, the therapeutic agent is associated with a taggant (that may be either labeled or unlabeled with deuterium), which in turn will generate a marker in the breath that is easily measurable. | 12-11-2014 |
20140355858 | VASCULAR ANATOMY MODELING DERIVED FROM 3-DIMENSIONAL MEDICAL IMAGE PROCESSING - Systems and methods to develop a vascular model of vascular trees that are captured with 3-Dimensional medical imaging data of a subject. Image processing iteratively traverses vessel image segments within the imaging data and creates a vessel model defined within a data structure that defines branch segments and bifurcation points where those branch segments split. The model generation algorithms incorporate strategies and parameters to identify and repair falsely identified bifurcations that reflect false inter-tree and intra-tree connections that can appear when processing images with complicated vessel trees. Accurate traversal of the vessel tree as portrayed in 3-Dimensional medical images is emphasized to correctly label branch generations and identify and repair erroneous interconnections between adjacent trees. | 12-04-2014 |
20140353502 | PHOTODETECTOR AND UPCONVERSION DEVICE WITH GAIN (EC) - Embodiments of the invention are directed to IR photodetectors with gain resulting from the positioning of a charge multiplication layer (CML) between the cathode and the IR sensitizing layer of the photodetector, where accumulating charge at the CML reduces the energy difference between the cathode and the CML to promote injection of electrons that result in gain for an electron only device. Other embodiments of the invention are directed to inclusion of the IR photodetectors with gain into an IR-to-visible up-conversion device that can be used in night vision and other applications. | 12-04-2014 |
20140343110 | USES OF 4'-DESFERRITHIOCIN ANALOGS - Macular degeneration, closed head injury, stroke, irritable bowel disease, and reperfusion injury are all associated with biological injury due to reactive oxygen species, probably due to focal iron overload in many instances. The present invention provides methods and pharmaceutical compositions for treating these diseases and conditions using desferrithiocin analogs of Formula (I). In certain embodiments, the analogs include a polyether moiety at the 4′-position of the phenyl ring of the compound. | 11-20-2014 |
20140341852 | CAPSID-MODIFIED RAAV VECTOR COMPOSITIONS AND METHODS THEREFOR - Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also provided are methods of preparing and using the disclosed capsid-protein-mutated rAAV constructs in a variety of diagnostic and therapeutic modalities, including, inter alia, as mammalian cell-targeting delivery agents, and as human gene therapy vectors. Also disclosed are large-scale production methods for capsid-modified rAAV expression vectors, viral particles, and infectious virions having improved transduction efficiencies over those of the corresponding, un-modified, rAAV vectors, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications. | 11-20-2014 |
20140339316 | USING CUSTOMER PREMISES TO PROVIDE ANCILLARY SERVICES FOR A POWER GRID - Techniques for providing ancillary services to a power grid using customer premises such as commercial buildings. The techniques may involve receiving a regulation signal from a grid operator that is specific to a commercial building and modifying power consumption by at least one power consumption component in the building based on the regulation signal. The power consumption component may be a fan of a Heating, Ventilation, and Air Conditioning (HVAC) system. Conducted experiments demonstrate that up to 15% of fan power capacity may be deployed for regulation purposes while maintaining indoor temperature deviation to no more than 0.2° C. The regulation signal may be tracked in a frequency band from about 4 seconds to 10 minutes. | 11-20-2014 |
20140330540 | RANDOM BODY MOVEMENT CANCELLATION FOR NON-CONTACT VITAL SIGN DETECTION - A method and system for cancelling body movement effect for non-contact vital sign detection is described. The method begins with sending on a first electromagnetic wave transceiver a first electromagnetic signal with a first frequency to a first side of a body, such as a person or animal. Simultaneously using a second electromagnetic wave transceiver a second electromagnetic signal is sent with a second frequency to a second side of a body, wherein the first frequency and the second frequency are different frequencies. A first reflected electromagnetic signal reflected back in response to the first electromagnetic wave on the first transceiver is received and a first baseband complex signal is extracted. Likewise a second reflected electromagnetic signal reflected back in response to the second electromagnetic wave on the second transceiver is received and a second baseband complex signal is extracted. The first baseband complex signal is mathematically combined with the second baseband complex signal to cancel out a Doppler frequency drift therebetween to yield a periodic Doppler phase effect. | 11-06-2014 |
20140328804 | Method for Treating or Preventing Graft Versus Host Disease - A method of treating or preventing graft versus host disease (GVHD) in a subject receiving a graft comprising hematopoietic cells is provided. The method comprises contacting the graft ex vivo with an amount of a Myxoma Virus effective to inhibit proliferation of T lymphocytes in the graft and to treat or prevent GVHD in the host subject following infusion of the graft into the subject. After the contacting of the graft with the Myxoma Virus, the method comprises transplanting the virus-treated graft into the subject. | 11-06-2014 |
20140323534 | USES OF 3'-DESFERRITHIOCIN ANALOGS - Macular degeneration, closed head injury, stroke, irritable bowel disease, and reperfusion injury are all associated with biological injury due to reactive oxygen species, probably due to focal iron overload in many instances. The present invention provides methods and pharmaceutical compositions for treating these diseases and conditions using desferrithiocin analogs of Formula (I). In certain embodiments, the analogs include a polyether moiety at the 3′-position of the phenyl ring of the compound. Formula (I). | 10-30-2014 |
20140319563 | LATERALLY ALIGNED COLLOIDAL NANORODS ASSEMBLIES - Nanorods assemblies that have lengths in excess of 50 microns to meters are formed from contacting rice-shaped colloidal superparticles that are aligned along the long axis of the colloidal superparticles. The rice-shaped colloidal superparticles are formed from a multiplicity of nanorods with a high degree of association that is end to end to form colloidal superparticles that are in excess of three microns in length and have a length to diameter ratio of about three or more. Methods of preparing the rice-shaped colloidal superparticles employ mixing with an additional ligand to the nanorods to bias the self assembly of the nanorods by solvophobic interactions. Methods of preparing the nanorods assemblies include the infusion of the rice-shaped colloidal superparticles into microchannels patterned on a substrate, wherein the rice-shaped colloidal superparticles' long axes align in the microchannels. | 10-30-2014 |
20140303041 | IN VITRO DIAGNOSTIC DEVICES FOR NERVOUS SYSTEM INJURY AND OTHER NEURAL DISORDERS - The present invention relates to an exemplary in vitro diagnostic (IVD) device used to detect the presence of and/or severity of neural injuries or neuronal disorders in a subject. The IVD device relies on an immunoassay which identifies biomarkers that are diagnostic of neural injury and/or neuronal disorders in a biological sample, such as whole blood, plasma, serum, cerebrospinal fluid (CSF). The inventive IVD device may measure one or more of several neural specific markers in a biological sample and output the results to a machine readable format wither to a display device or to a storage device internal or external to the IVD. | 10-09-2014 |
20140294675 | Marker Detection Method And Apparatus To Monitor Drug Compliance - The present invention includes systems and methods for monitoring therapeutic drug concentration in blood by detecting markers, such as odors, upon exhalation by a patient after the drug is taken, wherein such markers result either directly from the drug itself or from an additive combined with the drug. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor drug levels in blood. The invention further includes a reporting system capable of tracking drug concentrations in blood (remote or proximate locations) and providing the necessary alerts with regarding to ineffective or toxic drug dosages in a patient. | 10-02-2014 |
20140291570 | POROUS STABILIZED BEDS, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME - Disclosed herein is a method comprising disposing a first particle in a reactor; the first particle being a magnetic particle or a particle that can be influenced by a magnetic field, an electric field or a combination of an electrical field and a magnetic field; fluidizing the first particle in the reactor; applying a uniform magnetic field, a uniform electrical field or a combination of a uniform magnetic field and a uniform electrical field to the reactor; elevating the temperature of the reactor; and fusing the first particles to form a monolithic solid. | 10-02-2014 |
20140284325 | SOLID STATE HEATING SOURCE AND PLASMA ACTUATORS INCLUDING EXTREME MATERIALS - Solid state flow control devices, solid state heating sources, and plasma actuators are provided. A plasma actuator can include at least one powered electrode separated from at least one grounded electrode by a dielectric material. The dielectric material can be a ferroelectric material or a silica aerogel. Solid state flow control devices and solid state heating sources can include at least one such plasma actuator. | 09-25-2014 |
20140283152 | METHOD FOR ARTIFICIAL SELECTION - The present invention provides methods of determining the breeding value of an individual or determining the best pair of individuals to mate based on additive and non-additive factors. The invention further provides methods of breeding an individual selected by using a molecular marker-derived matrix comprising additive and non-additive effects. The invention also provides a kit for determining the Estimated Breeding Value of an individual. | 09-18-2014 |
20140276579 | DEVICES AND METHODS FOR SECURING AN ANTI-LEAK FEEDING TUBE FOR GASTRIC AND/OR INTESTINAL USE - Medical device designs for enteral nutrition that inhibit the relative motion of one device member to another device member are herein disclosed. The gastric and/or intestinal feeding tube shaft is disposed of teeth, furrows, ridges, indentions, tabs, or corrugations that operate with an external retaining member. Alternative embodiments utilize an external retaining member with a collet fitting that applies pressure against the gastric and/or intestinal feeding tube shaft. The assemblies prevent the relative motion of the internal retention member relative to the external retaining member and assist in maintaining the internal retention member against the gastric wall. | 09-18-2014 |
20140276048 | AUTOMATIC CONTINUOUS A-MODE ULTRASOUND MONITOR FOR PNEUMOTHORAX - Automated continuous analysis of ultrasound data is provided to determine occurrence of pneumothorax in a patient. Specifically, A-mode ultrasound data is processed by a processing system to identify automatically if pneumothorax has occurred in a patient. | 09-18-2014 |
20140259876 | Mosquito Control Device Using Durable Coating Embedded Pesticides - Dual action lethal containers, systems and methods and novel compositions and formulas which are used to kill mosquitoes and their larvae. Generally pyramid shaped containers can have combined interior larvacidal and adultacidal coatings above and below a side opening in the container. A removable inclined grate cap can also allow for mosquitoes to enter into the container. Inclined stacked walls inside the container form attractive surfaces for mosquitoes to breed. Water-holding containers, such as flower pots, water holding dishes used under plant pots, vases, bird baths, and fountains and storm water inlets, can be coated with novel larvicide and/or adulticide coatings. Small objects can be coated with larvicide or larvicide and adulticide combination, which can be dropped in water-holding containers which can leach out pesticide over time which prevents mosquitoes from breeding in the water-holding containers. | 09-18-2014 |
20140256802 | Dual-AAV Vector-Based Systems and Methods for Delivering Oversized Genes to Mammalian Cells - Disclosed are materials and methods for treating diseases of the mammalian eye, and in particular, Usher syndrome 1B (USH1B). The invention provides AAV-based, dual-vector systems that facilitate the expression of full-length proteins whose coding sequences exceed that of the polynucleotide packaging capacity of an individual AAV vector. In one embodiment, vector systems are provided that include i) a first AAV vector polynucleotide that includes an inverted terminal repeat at each end of the polynucleotide and a suitable promoter followed by a partial coding sequence that encodes an N-terminal portion of a full-length polypeptide; and ii) a second AAV vector polynucleotide that includes an inverted terminal repeat at each end of the polynucleotide and a partial coding sequence that encodes a C-terminal portion of a full-length polypeptide, optionally followed by a polyadenylation (pA) signal sequence. In another embodiment, the vector system includes i) a first AAV vector polynucleotide comprising an inverted terminal repeat at each end, a suitable promoter followed by a partial coding sequence that encodes an N-terminal portion of a full-length polypeptide followed by a splice donor site and intron and ii) a second AAV vector polynucleotide comprising an inverted terminal repeat at each end, followed by an intron and a splice-acceptor site for the intron, followed by a partial coding sequence that encodes a C-terminal portion of a full-length polypeptide, optionally followed by a polyadenylation (pA) signal sequence. The coding sequence or the intron sequence in the first and second AAV vectors preferably includes a sequence region that overlaps. | 09-11-2014 |
20140243631 | NOVEL PULSE OXIMETER PROBES AND METHODS FOR USING THE SAME - Provided according to embodiments of the invention are photoplethysmography probes designed for use on a user's nasal alar. Methods of using such photoplethysmography probes are also provided herein. | 08-28-2014 |
20140243630 | Methods And Devices For Central Photoplethysmographic Monitoring - Provided according to embodiments of the present invention are methods of monitoring individuals that include securing a photoplethysmography probe to at least one of a pre-auricular region and a post-auricular region of the individual and obtaining photoplethysmography signals from the photoplethysmography probe. Photoplethysmography probes and helmets related to such methods are also described herein. | 08-28-2014 |
20140242148 | ANTIMICROBIAL MATERIALS AND METHODS - The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products. | 08-28-2014 |
20140242074 | MATERIALS AND METHODS FOR MODULATING ACTIVITY OF BONE MARROW DERIVED CELLS - The subject invention provides methods for recruitment of bone marrow-derived cells, including bone marrow-derived endothelial cells (BMDEC), and increasing their function by administration of relaxin. The methods of the invention can be used in, for example, treating 5 conditions amenable to treatment by recruitment of bone marrow-derived cells, such as BMDEC and bone marrow-derived angio-osteogcnic progenitor cell. | 08-28-2014 |
20140235680 | DESFERRITHIOCIN POLYETHER ANALOGUES - Compounds represented by structural formulas described herein, such as Structural Formula (I): | 08-21-2014 |
20140221122 | BEND-TWIST COUPLED GOLF CLUB SHAFT - Embodiments of the subject invention relate to a method and apparatus for providing a golf club shaft that has coupling between one or more bending modes and one or more twisting modes of deformation. In a specific embodiment, bending the shaft along a central longitudinal axis of the shaft in a plane of bending results in twisting of the shaft about the same central longitudinal axis of the shaft. | 08-07-2014 |
20140217365 | PHOTODETECTOR AND UPCONVERSION DEVICE WITH GAIN (EC) - Embodiments of the invention are directed to IR photodetectors with gain resulting from the positioning of a charge multiplication layer (CML) between the cathode and the IR sensitizing layer of the photodetector, where accumulating charge at the CML reduces the energy difference between the cathode and the CML to promote injection of electrons that result in gain for an electron only device. Other embodiments of the invention are directed to inclusion of the IR photodetectors with gain into an IR-to-visible up-conversion device that can be used in night vision and other applications. | 08-07-2014 |
20140217284 | METHOD AND APPARATUS FOR DETECTING INFRARED RADIATION WITH GAIN - Photodetectors, methods of fabricating the same, and methods using the same to detect radiation are described. A photodetector can include a first electrode, a light sensitizing layer, an electron blocking/tunneling layer, and a second electrode. Infrared-to-visible upconversion devices, methods of fabricating the same, and methods using the same to detect radiation are also described. An Infrared-to-visible upconversion device can include a photodetector and an OLED coupled to the photodetector. | 08-07-2014 |
20140215901 | Bed Bug Control Devices, Systems and Methods Using Heat and Volatile Insecticides - Devices, apparatus, systems and methods of volatizing insecticide-impregnated strips, such as a dichlorvos resin strip, using heat that can treat a closed and sealed space unit such as a room or building for bed bugs and other undesirable insects. At least one volatile impregnated strip can be positioned in a cage sandwiched between heating members such as electrical heating elements and heated plates. Temperature and time for heating can be controlled. Fans and blowers can help circulate the volatized air so that occupants can return safely to use the space unit within approximately 24 to approximately 36 hours. | 08-07-2014 |
20140213136 | FAST RESPONSE NANOFIBER ARTICLES WITH TUNABLE WETTABILITY AND BULK PROPERTIES - A fibrous properties-switching article comprises a mat consisting of fibers having a fiber diameter of 2 microns or less. The fibers comprise a polymer, copolymer, polymer blend, or polymer network, wherein the fibers have a diameter of 2 gm or less. The surface and/or bulk property of the mat changes over a range of temperatures, wherein the polymer, copolymer, polymer blend, or polymer network undergoes a structural change over the range of temperatures. The fiber mat is formed by electrospinning. In an exemplary embodiment, a blend of polystyrene and poly((N-isopropyl acrylamide) (b1-PS/PNIPA) in dimethylformamide (DMF) is electrospun to form a mat consisting of fibers with a diameter less than 2 μm that shows a transition from a superhydrophilic surface to a nearly superhydrophobic surface over a temperature range from 30° C. to 45° C. A fiber mat formed by electrospinning a DMF solution comprising poly(N-isopropyl acrylamide-co-methacylicacid) (PNIPAMAA), comprises fibers having a diameter less than 2 μm and are cross linked after spinning. The crosslinked PNIPAMAA, (x1-PNIPAMAA) fiber mat displays a transition from a hydrophilic surface to a nearly hydrophobic surface over a temperature range from 30° C. to 45° C. | 07-31-2014 |
20140212933 | OVER-EXPRESSION OF A PUTATIVE OXIDOREDUCTASE (UCPA) FOR INCREASING FURFURAL OR 5-HYDROXYMETHYLFURFURAL TOLERANCE - The subject invention pertains to overexpression of a putative oxidoreductase (ucpA) for increasing furfural tolerance in genetically modified microorganisms. Genetically modified microorganisms capable of overexpressing UcpA are also provided. Increased expression of ucpA was shown to increase furfural tolerance by 50%, and to permit the fermentation of sugars to products in the presence of 15 mM furfural. | 07-31-2014 |
20140208982 | TRANSPARENT INORGANIC-ORGANIC HYBRID MATERIALS VIA AQUEOUS SOL-GEL PROCESSING - A sol to form an inorganic-organic hybrid coating having a thick highly transparent hard coating is described. The hybrid coating is formed from a combined aqueous sol with least one hydrolyzable silane and at least one hydrolyzable metal oxide precursor where the only organic solvents present are those liberated upon hydrolysis of the silanes and metal oxide precursors. In one embodiment an inorganic-organic hybrid coating is formed by combination of a sol, prepared by the hydrolysis of tetraethoxysilane and γ-glycidoxypropyltrimethoxysilane with an excess of water, and a sol, prepared by the hydrolysis of titanium tetrabutoxide and γ-glycidoxypropyltrimethoxysilane with a deficiency of water. A plastic substrate can be coated with the combined sol and the combined sol gelled to a thickness of at least 5 μm with heating to less than 150° C. | 07-31-2014 |
20140201867 | MATERIAL AND METHODS TO INCREASE PLANT GROWTH AND YIELD - The present invention relates to materials and methods for modulating growth rates, yield, and/or resistance to drought conditions in plants. In one embodiment, a method of the invention comprises increasing expression of an hc1 gene (or a homolog thereof that provides for substantially the same activity), or increasing expression or activity of the protein encoded by an hc1 gene thereof, in a plant, wherein expression of the hc1 gene or expression or activity of the protein encoded by an hc1 gene results in increased growth rate, yield, and/or drought resistance in the plant. | 07-17-2014 |
20140193518 | KINASE INHIBITOR COMPOUNDS - The invention relates to kinase inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating disorders, especially cancer. | 07-10-2014 |
20140193072 | ADAPTIVE BACKGROUND ESTIMATION - Various methods and systems are provided for adaptive background estimation. In one embodiment, among others, a signal processing device includes at least one processing unit and a memory storing a background estimation system executable in the at least one processing unit. The background estimation system, when executed, causes the signal processing device to separate foreground objects from at least one image frame in a sequence of image frames based at least in part upon a correntropy cost function. In another embodiment, a method includes obtaining an image frame from a sequence of image frames; performing correntropy filtering on the image frame to separate foreground objects from the image frame; and providing the foreground objects for rendering. The correntropy filtering may adapt to compensate for diffusion effects in the image frame. | 07-10-2014 |
20140191243 | PATTERNED ARTICLES AND LIGHT EMITTING DEVICES THEREFROM - A patterned article includes a substrate support having planar substrate surface portions including a substrate material having a substrate refractive index. A patterned surface is on the substrate support including a plurality of features lateral to the planar substrate surface portions protruding above a height of the planar substrate surface portions. At least a top surface of the plurality of features include an epi-blocking layer including at least one of (i) a non-single crystal material having a refractive index lower as compared to the substrate refractive index and (ii) a reflecting metal or a metal alloy (reflecting material). The epi-blocking layer is not on the planar substrate surface portions. | 07-10-2014 |
20140175410 | TRANSPARENT INFRARED-TO-VISIBLE UP-CONVERSION DEVICE - Embodiments of the invention are directed to a transparent up-conversion device having two transparent electrodes. In embodiments of the invention, the up-conversion device comprises a stack of layers proceeding from a transparent substrate including an anode, a hole blocking layer, an IR sensitizing layer, a hole transport layer, a light emitting layer, an electron transport layer, a cathode, and an antireflective layer. In an embodiment of the invention, the up-conversion device includes an IR pass visible blocking layer, | 06-26-2014 |
20140175281 | MULITPLE CONTROLLED ELECTROCHROMIC DEVICES FOR VISIBLE AND IR MODULATION - An electrochromic device (ECD) includes an electrochromic cell and, optionally, one or more additional electrochromic cells where all cells are parallel, and where at least one of the electrodes of one of the cells comprises a single-walled carbon nanotube (SWNT) film The electrochromic cells allow the control of transmittance of two or more different portions of the electro-magnetic spectrum through the ECD. One cell can control the transmittance of visible radiation while the other cell can control the transmittance of IR radiation. The ECD can be employed as a “smart window” to control the heat and light transmission through the window. The ECD can be in the form of a laminate that can be added to an existing window. | 06-26-2014 |
20140170409 | LOW-WEAR FLUOROPOLYMER COMPOSITES - A low-wear fluoropolymer composite body comprises at least one fluoropolymer and additive particles dispersed therein. Also provided is a process for the fabrication of such a fluoropolymer composite body. The composite body exhibits a low wear rate for sliding motion against a hard counterface, and may be formulated with either melt-processible or non-melt-processible fluoropolymers. | 06-19-2014 |
20140168637 | SIMULTANEOUS REFRACTIVE INDEX AND THICKNESS MEASUREMENTS WITH A MONOCHROMATIC LOW-COHERENCE INTERFEROMETER - A scanning monochromatic spatial low-coherent interferometer (S-LCI) can be used to simultaneously measure geometric thickness and refractive index. The probe beam of the scanning S-LCI can be an off-axis converging single wavelength laser beam, and the decomposed incident angles of the beam on the sample can be accurately defined in the Fourier domain. The angle dependent phase shift of a plane parallel plate or other sample can be obtained in a single system measurement. From the angle dependent phase shift, the geometric thickness and refractive index of the sample can be simultaneously obtained. Additionally or alternatively, the S-LCI system can interrogate the sample to profile the location and refractive index of one or more layers within the sample using the disclosed techniques. | 06-19-2014 |
20140168461 | SYSTEMS AND METHODS FOR ESTIMATING THE STRUCTURE AND MOTION OF AN OBJECT - In one embodiment, the structure and motion of a stationary object are determined using two images and a linear velocity and linear acceleration of a camera. In another embodiment, the structure and motion of a stationary or moving object are determined using an image and linear and angular velocities of a camera. | 06-19-2014 |
20140158132 | Methods Of Monitoring Oxygenation By Positive End Expiratory Pressure Using Photoplethysmography - The present invention relates to novel lip/cheek probes for detection of pulse-based differences in light absorbence across the vascularized tissue of a lip or cheek of a patient. These probes are fabricated to provide signals to estimate arterial oxygen saturation, and/or to obtain other photoplethysmographic data. The present invention also relates to a combined probe/cannula. The present invention also relates to other devices that combine a pulse oximeter probe with a device supplying oxygen or other oxygen-containing gas to a person in need thereof, and to sampling means for exhaled carbon dioxide in combination with the novel lip/cheek probes. In certain embodiments, an additional limitation of a control means to adjust the flow rate of such gas is provided, where such control is directed by the blood oxygen saturation data obtained from the pulse oximeter probe. | 06-12-2014 |
20140155713 | Devices, Systems And Methods For Plethysmographic Monitoring At The Nose - The present invention relates to optimized gas supply utilizing photoplethysmography. Flow rate, pressure or amount of gas is adjusted as a function of blood oxygen saturation data, photoplethysmography signals, or both, obtained from the pulse oximeter probe. | 06-05-2014 |
20140155704 | Methods And Systems For Respiratory Monitoring With Photoplethysmography - The present invention relates to optimized gas supply utilizing photoplethysmography. Flow rate, pressure or amount of gas is adjusted as a function of blood oxygen saturation data, photoplethysmography signals, or both, obtained from the pulse oximeter probe. | 06-05-2014 |
20140155490 | THERAPEUTIC COMPOUNDS - The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C disorders, including diseases and disorders mediated by GPCRs. | 06-05-2014 |
20140154341 | BIORESORBABLE METAL ALLOY AND IMPLANTS MADE OF SAME - Disclosed herein is a non-toxic, bioresorbable, magnesium based alloy for use in production of implants. Specifically exemplified herein are alloy embodiments useful for orthopedic implants. Also disclosed are alloy materials that incorporate magnesium, calcium and strontium. | 06-05-2014 |
20140141493 | RECOMBINANT HOST CELLS AND MEDIA FOR ETHANOL PRODUCTION - Disclosed are recombinant host cells suitable for degrading an oligosaccharide that have been optimized for growth and production of high yields of ethanol, and methods of making and using these cells. The invention further provides minimal media comprising urea-like compounds for economical production of ethanol by recombinant microorganisms. Recombinant host cells in accordance with the invention are modified by gene mutation to eliminate genes responsible for the production of unwanted products other than ethanol, thereby increasing the yield of ethanol produced from the oligosaccharides, relative to unmutated parent strains. The new and improved strains of recombinant bacteria are capable of superior ethanol productivity and yield when grown under conditions suitable for fermentation in minimal growth media containing inexpensive reagents. Systems optimized for ethanol production combine a selected optimized minimal medium with a recombinant host cell optimized for use in the selected medium. Preferred systems are suitable for efficient ethanol production by simultaneous saccharification and fermentation (SSF) using lignocellulose as an oligosaccharide source. The invention also provides novel isolated polynucleotide sequences, polypeptide sequences, vectors and antibodies. | 05-22-2014 |
20140137292 | CITRUS TREES WITH RESISTANCE TO CITRUS CANKER - Methods and compositions for making citrus plants with enhanced resistance to Asiatic citrus canker (ACC) and other forms of citrus canker caused by | 05-15-2014 |
20140134206 | INFLAMMATION AND IMMUNITY TREATMENTS - Therapeutic use of extracts containing proanthocyanidin including treating disorders, e.g., inflammatory disorders, e.g., inflammatory bowel disease, Crohn's disease, ulcerative colitis, indeterminate colitis, microscopic colitis, collagenous colitis, and irritable bowel syndrome. Methods of increasing a subject's immunological resistance to an infection and/or treating the infection. The infection can be, e.g., a bacterial, viral, or fungal infection. The methods can include, e.g., selecting a subject that has, or is at risk of developing, an infection, e.g., a bacterial, viral, or fungal infection, or a combination thereof; providing a composition comprising at least about 10% proanthocyanidin by weight; and administering to the subj ect an amount of the composition to the subject, to thereby increase a subject's immunological resistance to an infection and/or to treat the infection. | 05-15-2014 |
20140127675 | MATERIALS AND METHODS FOR DETECTING TOXINS, PATHOGENS AND OTHER BIOLOGICAL MATERIALS - Embodiments of the present invention provide binding molecule-functionalized high electron mobility transistors (HEMTs) that can be used to detect toxins, pathogens and other biological materials. In a specific embodiment, an antibody-functionalized HEMT can be used to detect botulinum toxin. The antibody can be anchored to a gold-layered gate area of the | 05-08-2014 |
20140124793 | SMOOTH DIAMOND SURFACES AND CMP METHOD FOR FORMING - A method of chemical mechanical polishing (CMP) a diamond containing surface includes providing a slurry including a plurality of particles, at least one oxidizer, and at least one acid, wherein the slurry has a pH≦3 or pH greater than 11. At least an outer surface of the plurality of particles is softer than the diamond surface or the particles are diamond particles averaging less than (<)2 μm in size. The diamond surface is pressed with respect to a polishing pad providing a Shore D Hardness less than 99 having the slurry in between while rotating the polishing pad relative to the diamond surface to form a smooth diamond surface having a root mean square (rms) surface roughness less than 15 nm. | 05-08-2014 |
20140113284 | DIFFERENTIAL DETECTION AND QUANTIFICATION OF OXALOBACTER - Disclosed herein are PNA probes, or PNA probe sets and their use as well as kits useful for the analysis of certain | 04-24-2014 |
20140111652 | INFRARED IMAGING DEVICE INTEGRATING AN IR UP-CONVERSION DEVICE WITH A CMOS IMAGE SENSOR - Imaging devices include an IR up-conversion device on a CMOS imaging sensor (CIS) where the up-conversion device comprises a transparent multilayer stack. The multilayer stack includes an IR sensitizing layer and a light emitting layer situated between a transparent anode and a transparent cathode. In embodiments of the invention, the multilayer stack is formed on a transparent support that is coupled to the CIS by a mechanical fastener or an adhesive or by lamination. In another embodiment of the invention, the CIS functions as a supporting substrate for formation of the multilayer stack. | 04-24-2014 |
20140105867 | BLOCKAGE OF PAI-1 IN DIABETIC CD34+ STEM CELLS CORRECTS CELLULAR DYSFUNCTION - Disclosed herein are methods of enhancing repair of vascular lesions involving the administration of cells in which PAI-1 expression and/or activity has been transiently blocked. Other methods involve the administration of a PAI-1 blocking agent to a subject who has a vascular lesion or is at risk of developing a vascular lesion. Alternatively, a PAI-1 blocking agent and treated cells are co-administered to a subject in need thereof. | 04-17-2014 |
20140101985 | SEMIOCHEMICAL RESERVOIR TO ATTRACT SUBTERRANEAN TERMITES TUNNELING IN SOIL - The present invention relates generally to polymer devices impregnated with semiochemical attractants for termites. The materials for delivering the semiochemicals are preferably cellulose-free. Devices of the subject invention are placed in soil and provide a slow-release and permeation of the semiochemicals into the adjacent soil so that termites tunneling in the vicinity are directed toward the chemical sources. Because the semiochemicals are impregnated in the polymer, the device also protects the semiochemicals so that they do not degrade rapidly under field conditions. In a preferred embodiment, the subject invention comprises a durable station housing, preferably with a removable bait, wherein the body of the station housing itself is impregnated with a semiochemical attractant. | 04-17-2014 |
20140100159 | USE OF RELAXIN TO RESTORE MATERNAL PHYSIOLOGY IN PREGNANCIES CONVEIVED BY ASSISTED REPRODUCTIVE TECHNOLOGIES - The subject invention relates to methods for improving a subject's vasculature to normalize maternal hemodynamics, particularly in subjects attempting to conceive via assisted reproductive technologies, and comprises increasing relaxin levels in a subject or increasing any one or more of: relaxin synthesis, relaxin receptor synthesis, relaxin binding to the relaxin receptor, or relaxin receptor activity. | 04-10-2014 |
20140094670 | Methods And Systems For Monitoring Respiration With Photoplethysmography - The present invention relates to novel lip/cheek probes for detection of pulse-based differences in light absorbence across the vascularized tissue of a lip or cheek of a patient. These probes are fabricated to provide signals to estimate arterial oxygen saturation, and/or to obtain other photoplethysmographic data. The present invention also relates to a combined probe/cannula. The present invention also relates to other devices that combine a pulse oximeter probe with a device supplying oxygen or other oxygen-containing gas to a person in need thereof, and to sampling means for exhaled carbon dioxide in combination with the novel lip/cheek probes. In certain embodiments, an additional limitation of a control means to adjust the flow rate of such gas is provided, where such control is directed by the blood oxygen saturation data obtained from the pulse oximeter probe. | 04-03-2014 |
20140093533 | POLYPEPTIDES AND VECTORS FOR TARGETING HER2/NEU EXPRESSING CELLS AND USES THEREOF - Various aspects of the invention provide for capsids, parvovirus capsids, hybrid parvovirus capsids, parvovirus vectors, hybrid parvovirus vectors, hybrid parvovirus particles and parvovirus particles containing polypeptides in which the sequence YCDGFYACYMDV (SEQ ID NO: 3) has been substituted into the VP2 loop of the B19 capsid protein. Polypeptides in which the sequence YCDGFYACYMDV (SEQ ID NO: 3) has been substituted into the VP2 loop of the B19 capsid protein are also provided (e.g., SEQ ID NO: 2). Other aspects of the invention provide capsids, parvovirus capsids, hybrid parvovirus capsids, parvovirus vectors, hybrid parvovirus vectors, hybrid parvovirus particles and parvovirus particles containing a polypeptide comprising SEQ ID NO: 2. Also provided in various aspects of the invention are pharmaceutical compositions and methods of delivering therapeutic agents and/or reporter peptides/proteins to target cells. Finally, methods of treating diseases characterized by cells expression HER2/neu receptors are also provided. | 04-03-2014 |
20140088016 | MACROCYCLIC THERAPEUTIC AGENTS AND METHODS OF TREATMENT - The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders. | 03-27-2014 |
20140086795 | CONJUGATED POLYELECTROLYTE CAPSULES: LIGHT ACTIVATED ANTIMICROBIALS - Hollow conjugated polyelectrolyte (HCPE) microcapsules contain at least one conjugated polyelectrolyte and at least one other polyelectrolyte of complementary charge and the microcapsule has a hollow core. The conjugated polyelectrolyte is a polymer with a multiplicity of charged repeating units where a portion of the charged repeating units form a pi-conjugated sequence. The complementary polyelectrolyte is a polymer with a complementary charged repeating unit to the charged repeating units of the conjugated polyelectrolyte. The HCPE microcapsules can be formed by successively coating a sacrificial core with alternating layers of complementary polyelectrolytes, at least one of which is a conjugated polyelectrolyte. The sacrificial core can be removed to form the hollow center of a HCPE microcapsule. The HCPE microcapsules can be contacted with a medium containing microbes where the HCPE microcapsules associate with the microbes and efficiently kill the microbes when irradiated with light or other electromagnetic radiation. | 03-27-2014 |
20140083752 | NANOTUBE DISPERSANTS AND DISPERSANT FREE NANOTUBE FILMS THEREFROM - A degradable polymeric nanotube (NT) dispersant comprises a multiplicity of NT associative groups that are connected to a polymer backbone by a linking group where there are cleavable groups within the polymer backbone and/or the linking groups such that on a directed change of conditions, bond breaking of the cleavable groups results in residues from the degradable polymeric NT dispersant in a manner where the associative groups are uncoupled from other associative groups, rendering the associative groups monomelic in nature. The degradable polymeric nanotube (NT) dispersant can be combined with carbon NTs to form a NT dispersion that can be deposited to form a NT film, or other structure, by air brushing, electrostatic spraying, ultrasonic spraying, ink-jet printing, roll-to-roll coating, or dip coating. The deposition can render a NT film that is of a uniform thickness or is patterned with various thicknesses. Upon deposition of the film, the degradable polymeric nanotube (NT) dispersant can be cleaved and the cleavage residues removed from the film to yield a film where contact between NTs is unencumbered by dispersants, resulting in highly conductive NT films. | 03-27-2014 |
20140073800 | ONO PINCER LIGANDS AND ONO PINCER LIGAND COMPRISING METAL COMPLEXES - Embodiments of the invention are directed to ONO pincer ligands that can be in a trianionic, protonated or protonated equivalent form. The ONO pincer ligand can be combined with a transition metal comprising compound to form an ONO pincer ligand comprising transition metal complex. By choice of the ONO pincer ligand structure, the steric and electronic properties of the transition metal complexes therefrom can be controlled. The ONO pincer ligands comprise a central nitrogen atom that is disubstituted with a pair of three atom comprising bridges where the three atoms are three sp | 03-13-2014 |
20140070191 | METHOD AND APPARATUS FOR PROVIDING A WINDOW WITH AN AT LEAST PARTIALLY TRANSPARENT ONE SIDE EMITTING OLED LIGHTING AND AN IR SENSITIVE PHOTOVOLTAIC PANEL - Embodiments of the subject invention relate to a method and apparatus for providing a apparatus that can function as a photovoltaic cell, for example during the day, and can provide solid state lighting, for example at night. The apparatus can therefore function as a lighting window. An embodiment can integrate an at least partially transparent one-side emitting OLED and a photovoltaic cell. The photovoltaic cell can be sensitive to infrared light, for example light having a wavelength greater than 1 μm. The apparatus can be arranged such that the one direction in which the OLED emits is toward the inside of a building or other structure and not out into the environment. | 03-13-2014 |
20140067008 | PROTECTING AIRWAYS - An airway of a patient is protected from intrusion of contaminants by monitoring muscles of the patient to detect an attempted cough or swallow, and applying an electrical stimulus to the neck of the patient, varying amplitude and/or frequency over time, the applied electrical stimulus operates to promote an efficacious cough or swallow. The electrical stimulus induces a voltage within a range of greater than zero volts and less than 20 volts, and the frequency have patterned changes between at least about 4 Hz to not more than about 30 Hz. The monitoring is carried out by an electronic device, and the patient may indicate to the electronic device that a swallow or cough is impending. | 03-06-2014 |
20140064624 | SYSTEMS AND METHODS FOR ESTIMATING THE GEOGRAPHIC LOCATION AT WHICH IMAGE DATA WAS CAPTURED - In some embodiments, a system and method for estimating the geographical location at which image data was captured with a camera identifies matching feature points between the captured images, estimates a pose of the camera during the image capture from the feature points, performs geometric reconstruction of a scene in the images using the estimated pose of the camera to obtain a reconstructed scene, and compares the reconstructed scene to overhead images of known geographical origin to identify potential matches | 03-06-2014 |
20140061617 | METHOD AND APPARATUS FOR INTEGRATING AN INFRARED (HR) PHOLOVOLTAIC CELL ON A THIN PHOTOVOLTAIC CELL - Embodiments of the subject invention relate to a method and apparatus for providing an at: least partially transparent one-side emitting OLED. The at least partially transparent one-side emitting OLED can include a mirror, such as a mirror substrate, substrate with a transparent anode and a transparent cathode. The mirror can allow at least a portion of the visible spectrum of light to pass through, while also reflecting at least another portion of the visible spectrum of light. The mirror can reflect at least a portion of the visible light emitted by a light emitting layer of the OLED incident on a first surface of the mirror, while allowing another portion of the visible light incident on a second surface of the mirror to pass through the mirror. | 03-06-2014 |
20140060613 | METHOD AND APPARATUS FOR INTEGRATING AN INFRARED (IR) PHOTOVOLTAIC CELL ON A THIN FILM PHOTOVOLTAIC CELL - Embodiments of the subject invention relate to solar panels, methods of fabricating solar panels, and methods of using solar panels to capture and store solar energy. An embodiment of a solar panel can include a photovoltaic cell that is sensitive to visible light and an infrared photovoltaic cell that is sensitive to light having a wavelength of greater than 0.70 μm. | 03-06-2014 |
20140052379 | DETECTION OF SINKHOLES OR ANOMALIES - Systems and methods are provided for detecting subterranean properties associated with a geological domain. One example method may comprise obtaining waveform information corresponding to a geological domain. The method may further comprise performing a global inversion on the waveform information. Furthermore, the method may comprise performing a deterministic inversion on the waveform information. The method may also comprise determining one or more subterranean properties associated with the geological domain based at least in part on the global inversion and the deterministic inversion. | 02-20-2014 |
20140031400 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT - The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation. | 01-30-2014 |
20140030812 | DEVICES AND METHODS FOR MEASURING THE ACIDITY OF AIRBORNE MATTER USING UV-VISIBLE SPECTROMETRY - Devices and methods for measuring the acidity of airborne matter are provided. A filter can be impregnated with an indicator dye which changes color in response to changes in acidity. After the sample passes through the filter, the filter can be analyzed using UV-visible spectrometry. | 01-30-2014 |
20140024086 | OVER-EXPRESSION OF NADH-DEPENDENT OXIDOREDUCTASE (FUCO) FOR INCREASING FURFURAL OR 5-HYDROXYMETHYLFURFURAL TOLERANCE - The subject invention pertains to the discovery that the NADH-dependent propanediol oxidoreductase (FucO) can reduce furfural. This allows for a new approach to improve furfural tolerance in bacterial and/or yeast cells used to produce desired products. Thus, novel biocatalysts (bacterial, fungal or yeast cells) exhibiting increased tolerance to furfural and 5-hydroxymethylfurfural (5-HMF) are provided as are methods of making and using such biocatalysts for the production of a desired product. | 01-23-2014 |
20140023615 | THERMO-SENSITIVE, MUCOADHESIVE OR DERMOADHESIVE, AND PENETRATION-ENHANCING FORMULATIONS FOR TOPICAL DELIVERY OF THERAPEUTICS - The present invention provides thermo-sensitive, mucoadhesive biopolymer formulations that enhance the penetration of therapeutics across the skin or mucosal surfaces. In a preferred embodiment, the biopolymer formulation comprises co-polymer of poloxamer 188 and propylene glycol, laurocapram and, optionally, one or more therapeutic agents. Also provided are uses of the biopolymer formulations for topical therapy of cancer including cervical cancer. | 01-23-2014 |
20130338018 | PRIMERS, SEQUENCES AND RECOMBINANT PROBES FOR IDENTIFICATION OF MYCOBACTERIUM SPECIES - The subject invention pertains to an assay and a method for diagnosing, identifying and/or differentiating microorganisms, and in particular bacteria such as | 12-19-2013 |
20130337549 | MATERIALS AND METHODS FOR NERVE GRAFTING - The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue using nerve grafts and preparation of nerve grafts. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of the subject invention comprise one or more chondroitin sulfate proteoglycan (CSPG)-degrading enzymes that promote axonal penetration into damaged nerve tissue and nerve graft. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods. The invention also includes storage solutions for nerve tissue. | 12-19-2013 |
20130334520 | GERMOLE CONTAINING CONJUGATED MOLECULES AND POLYMERS - Embodiments of the invention are directed to Ge comprising heterocyclic compounds which can be used for the preparation of homopolymers and copolymers. The copolymers can be donor-acceptor (DA) alternating copolymers where the donor unit is a Ge comprising heterocyclic unit. The polymers can be used as materials in solar cells and other photovoltaic devices, transistors, diodes, light emitting devices (LEDs), conductors, supercapacitors, batteries, and electrochromic devices. | 12-19-2013 |
20130330310 | EX VIVO DEVELOPMENT, EXPANSION AND IN VIVO ANALYSIS OF A NOVEL LINEAGE OF DENDRITIC CELLS - Disclosed herein are new methods of producing a novel line of dendritic cells. The method comprises subjecting a sample of hematopoietic stem/precursor cells to a first feeder culture system that is supplemented with a first set of factors and a second feeder culture system supplemented with a second group of factors. The disclosure also pertains to new cell types that may be used as cancer immunotherapy. | 12-12-2013 |
20130328029 | Microcavity OLEDS for Lighting - Various methods and systems are provided for related to organic light emitting diodes (OLEDs) having a microcavity. In one embodiment, a white-light source includes a first microcavity organic light emitting diode (OLED) configured to emit a narrow spectrum of blue light; a second microcavity OLED configured to emit a narrow spectrum of green light, and a third microcavity OLED configured to emit a narrow spectrum of red light. In another embodiment, a light source includes a plurality of OLEDs disposed on a glass substrate. Each of the OLEDs is configured to emit light in substantially orthogonal to the glass substrate in a predefined spectrum. Each of the OLEDs includes a semi-reflecting mirror; and an emitting layer, where the emitting layer in each OLED corresponds to a respective color of light emitted by the OLED. | 12-12-2013 |
20130325367 | DETECTION OF STATIC TIP RESISTANCE OF A PILE - Systems and methods are provided for dynamically determining a static tip resistance of a dynamically-loaded component having a tip. One example method comprises receiving gauge data from one or more gauges associated with the component proximate the tip. The gauge data may represent measurements related to one or more impacts on the component. The example method may further comprise determining measured data and estimated data corresponding to the one or more impacts on the component based at least in part on the gauge data. Furthermore, the method may comprise performing an inversion to select the estimated data having the least amount of difference in comparison to the measured data. The method may also comprise determining the static tip resistance based at least in part on the selected estimated data. | 12-05-2013 |
20130310568 | METHOD FOR LINKING TWO OR MORE METALS FOR PHOTO AND ELECTRONIC MATERIALS - Embodiments of the invention are directed to bimetallic substituted triazole compounds and methods to prepare the compounds. The compounds include at least one 1,2,3-triazole that is substituted by two metal ions in the 1 and 4 or 5 position of the triazole ring. An iClick reaction between a metal acetylide and a metal azide results in the bimetallic substituted triazole ring. Depending on the metal acetylide and a metal azide used monomeric bimetallic substituted triazole compounds, oligomeric bimetallic triazole compounds, or polymeric bimetallic triazole compounds are formed. Polymeric bimetallic triazole compounds can be linear, branched, ladder, two-dimensional network, or three-dimensional networks. | 11-21-2013 |
20130304433 | Ligand Identification Scoring - Disclosed are various embodiments for systems and methods for predicting ligand with high binding affinities for protein receptors, as reflected by the binding free energy of the protein-ligand complex. A set of ligands and protein receptors are analyzed. Based on empirically determined data, such as van der Waal forces, hydrogen bonding, metal chelation, and other properties known for certain ligands, the binding free energy for a particular protein-ligand complex may be predicted. In addition, results may be filtered by sampling a range of predicted binding affinities by changing the arrangement in which the ligand docks with the protein receptor. | 11-14-2013 |
20130302341 | THERAPEUTIC AND DIAGNOSTIC APPLICATIONS TARGETING TNK-1 - Disclosed herein are novel antibodies specific to Tnk1 or variants thereof. Also disclosed are methods of using such antibodies. The methods include therapeutic methods against certain types of cancers or infections involving administration of novel antibodies or fragments thereof. Also, methods of using highly selective antibodies for detecting aberrant Tnk1 or functionally deficient Tnk1. | 11-14-2013 |
20130287729 | ANTIGEN-SPECIFIC, TOLERANCE-INDUCING MICROPARTICLES AND USES THEREOF - The present invention provides antigen-specific, tolerance-inducing microparticles for the targeted delivery of therapeutic agents to immune cells. In addition, the present invention allows for sustained release of therapeutic agents for a prolonged period of time. Also provided are therapeutic uses of the present invention for the prevention and/or treatment of immune diseases and autoimmune disorders. In a specific embodiment, the present invention provides treatment for type 1 diabetes. | 10-31-2013 |
20130281497 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT - The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as methods of modulating bone processes, and methods of treating bone-related disease, disorders, and symptoms thereof. | 10-24-2013 |
20130276355 | Dual Action Lethal Containers, Systems, Methods and Compositions for Killing Adult Mosquitos and Larvae - Dual action lethal containers, systems, methods, compositions and formulas used to kill mosquitoes and their larvae. The containers can have separate interior larvicidal and adulticidal coatings separated from each other by horizontal water line holes in the container. Another container can use a novel combined coating of a larvicidal and adulticidal coating. Unique compositions of adulticidal coatings, larvicidal coatings and combined adulticidal and larvicidal coatings can be used as liners. | 10-24-2013 |
20130273446 | HYDROGEN OXIDATION AND GENERATION OVER CARBON FILMS - An electrode comprises an acid treated, cathodically cycled carbon-comprising film or body. The carbon consists of single walled nanotubes (SWNTs), pyrolytic graphite, microcrystalline graphitic, any carbon that consists of more than 99% sp | 10-17-2013 |
20130266610 | STIMULATING ANTI-TUMOR IMMUNE RESPONSE AND BOOSTING CANCER IMMUNOTHERAPY VIA EXPRESSION OF 15-PGDH - Disclosed herein are methods and materials for inhibiting tumor growth by administering viral vectors to tumor cells. Particularly exemplified herein are methods of inhibiting tumor growth of colon tumors by delivering 15-PGDH to tumor environment. Antigen presenting cells may be coadministered with 15-PGDH. | 10-10-2013 |
20130266535 | METHYL SALICYLATE-BASED ATTRACTANTS FOR VECTORS OF CITRUS GREENING DISEASE - The present invention is directed to an insect attractant having an amount of methyl salicylate effective to attract a plurality of vectors of | 10-10-2013 |
20130245425 | System for Delivering Conformal Radiation Therapy While Simultaneously Imaging Soft Tissue - Devices and processes for performing magnetic resonance imaging of the anatomy of a patient during radiation therapy to measure and control the radiation dose delivered to the patient. | 09-19-2013 |
20130239808 | COLLECTING DEVICE FOR GASES AND AEROSOL, METHODS OF MAKING, AND METHODS OF USE - Embodiments of the present disclosure provide for collection devices, methods of making collection devices, methods of collecting gases and aerosol particles, and the like. | 09-19-2013 |
20130231456 | GREEN TO TRANSMISSIVE SOLUBLE ELECTROCHROMIC POLYMERS - Green to transmissive soluble electrochromic polymers are conjugated polymers having a plurality of repeating units where repeating units are a plurality of substituted dioxyheterocycle based donor groups coupled to an acceptor group. The conjugated polymer absorbs radiation within a first band of the visible spectrum and a second band of the visible spectrum when in a neutral state resulting in a green color and is transmissive when in an oxidized state. The polymers are soluble allowing processing of films and coatings from solution. | 09-05-2013 |
20130230695 | ARTICLES HAVING SUPERHYDROPHOBIC AND OLEOPHOBIC SURFACES - A thermoplastic article has a surface with a multiplicity of re-entrant structures extending from the article's surface where a conformal coating comprising a perfluoroalkane covers at least the distal portion of the re-entrant structures to render the article superhydrophobic and oleophobic. A method to prepare the article having a superhydrophobic and oleophobic surface comprises contacting a heated thermoplastic and a mold with voids having at least one dimension of 100 nm to 10 μm with a sufficient pressure to cause the thermoplastic to extend into the voids to form features that upon removal of the mold from the thermoplastic article results in re-entrant structures having at least one dimension of 100 nm to 5 μm. The surface having the re-entrant structures is conformally coated with a compound comprising a perfluoroalkane. Another method to prepare the article having a superhydrophobic and oleophobic surface comprises deposition of microparticles or nanoparticles and a resin on a surface of a substrate and curing the resin such that the microparticles or nanoparticles are adhered or mechanically fixed to the substrate with a portion of the microparticles or nanoparticles extending from the surface to form re-entrant structures. The microparticles or nanoparticles can comprise a perfluoroalkane or can be conformally coated with a compound comprising a perfluoroalkane, to render the surface superhydrophobic and oleophobic. | 09-05-2013 |
20130219556 | Viral Based Transient-Expression Vector System That Allows Multiple Applications - Disclosed herein are viral vectors suitable for transfection into woody trees for purposes of delivering and expressing beneficial genes. Specifically exemplified herein are vectors for transfecting citrus trees. The vectors allow for the expression of useful proteins, such as those that can protect the tree from disease. Specifically exemplified herein are methods of transfecting woody trees that allow multiple applications of vectors while avoiding superinfection exclusion. | 08-22-2013 |
20130218051 | SYSTEMS AND METHODS FOR EVALUATING LIVING TISSUE - Disclosed herein is a system for evaluating living tissue comprising a probe device having a probe, an actuator adapted to displace the probe in accordance with a programmed displacement profile, and force sensors that measure deflection of the probe at each position of the probe while the probe is in contact with the tissue. Disclosed herein too is a method comprising contacting a sample with a probe device having a probe, an actuator adapted to displace the probe in accordance with a programmed displacement profile, and force sensors that measure deflection of the probe at each position of the probe while the probe is in contact with the sample; measuring the deflection of the probe at each position of the probe at each point of contact with the sample; and determining whether any tissue present on the sample is a living tissue. | 08-22-2013 |
20130218049 | METHOD AND APPARATUS FOR DISINFECTING AND/OR SELF-STERILIZING A STETHOSCOPE USING PLASMA ENERGY - A method and apparatus for disinfecting and/or self-sterilizing at least a portion of the surface of a stethoscope is provided. Methods and devices are provided by which a device or apparatus can generate a sterilizing plasma such that a stethoscope, or portion of a stethoscope, can be placed within or near the device or apparatus so that the plasma disinfects and/or sterilizes and/or decontaminates at least a portion of the stethoscope. A method and apparatus are disclosed for providing a self-disinfecting and/or self-sterilizing and/or self-decontaminating stethoscope and stethoscope disinfecting and/or sterilization apparatus for disinfecting and/or sterilizing, respectively, all or at least a portion of a stethoscope. | 08-22-2013 |
20130217801 | SYNTHESIS OF DIOXYHETEROCYCLE-BASED POLYMERS - A method of polymerization for the preparation of conjugated polymers and copolymers comprising dioxypyrrole and/or dioxyfuran repeating units involves the halogen, N-haloimide, or N-haloamine promoted polymerization of monomers and/or oligomers comprising one or more dioxypyrrole and/or dioxyfuran units. The polymerization can be carried out over a wide range of temperatures and can be carried out with or without a solvent. The monomers allow the preparation of polymers having an oligomeric repeating unit comprising a conjugated unit other than a dioxypyrrole or dioxyfuran that is bound to two dioxypyrrole or dioxyfuran units. | 08-22-2013 |
20130216501 | THERAPEUTIC METHODS BASED ON TYROSINE-SUBSTITUTED, CAPSID-MODIFIED RAAV VECTORS - Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors. | 08-22-2013 |
20130210870 | DESFERRITHIOCIN POLYETHER ANALOGUES - A relatively non-toxic desazadesferrithiocin analog having the formula: | 08-15-2013 |
20130206988 | METHOD AND APPARATUS FOR INFRARED DETECTION AND DISPLAY - Embodiments of the subject invention relate to a method and apparatus for infrared (IR) detection. Organic layers can be utilized to produce a phototransistor for the detection of IR radiation. The wavelength range of the IR detector can be modified by incorporating materials sensitive to photons of different wavelengths. Quantum dots of materials sensitive to photons of different wavelengths than the host organic material of the absorbing layer of the phototransistor can be incorporated into the absorbing layer so as to enhance the absorption of photons having wavelengths associated with the material of the quantum dots. A photoconductor structure can be used instead of a phototransistor. The photoconductor can incorporate PbSe or PbS quantum dots. The photoconductor can incorporate organic materials and part of an OLED structure. A detected IR image can be displayed to a user. Organic materials can be used to create an organic light-emitting device. | 08-15-2013 |
20130203841 | Transduction Efficiency, Capsid-Modified rAAV Vectors and Methods of Use - Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors. | 08-08-2013 |
20130199995 | POROUS POLYMER MEMBRANES, METHODS OF MAKING, AND METHODS OF USE - Embodiments of the present disclosure may relate to porous polymer membranes, structures including porous polymer membranes, devices including porous polymer membranes, methods of using porous polymer membranes, methods of making porous polymer membranes, and the like. | 08-08-2013 |
20130199308 | SYSTEM AND METHOD FOR ASSESSING THE PERFORMANCE OF AN ATTITUDE CONTROL SYSTEM FOR SMALL SATELLITES - Various embodiments of the present invention include systems and methods for assessing the performance of an actuator of a attitude control system (ACS), such as a control moment gyroscope (CMG). In one embodiment, a system includes a support bracket assembly coupled to an actuator, wherein the actuator is configured to generate an output torque. The system also includes at least one sensor assembly coupled to the support bracket assembly, wherein the at least one sensor assembly includes a sensor configured to measure the output torque about at least one axis of the support bracket assembly while the support bracket assembly remains substantially motionless. | 08-08-2013 |
20130190508 | CATALYSTS CONTAINING N-HETEROCYCLIC CARBENES FOR ENANTIOSELECTIVE SYNTHESIS - Novel N-heterocyclic carbene ligand precursors, N-heterocyclic carbene ligands and N-heterocyclic metal-carbene complexes are provided. Metal-carbene complexes comprising N-heterocyclic carbene ligands can be chiral, which are useful for catalyzing enantioselective synthesis. Methods for the preparation of the N-heterocyclic carbene ligands and N-heterocyclic metal-carbene complexes are given. | 07-25-2013 |
20130189257 | USE OF PKC-IOTA INHIBITORS FOR THE TREATMENT OF BREAST CANCER - The subject invention pertains to uses of PKC-iota inhibitors for treatment of breast cancer. In one embodiment, the subject invention provides novel uses of 1H-imidazole-4-carboxamide, 5-amino-1-[2,3 -dihydroxy-4-[(phosphonooxy) methyl]cyclopentyl]-,[1R-(1α, 2β, 3β, 4α)] (ICA-1) and related compounds for treatment of breast cancer. The compounds of the subject invention have potent anti-proliferative effects against human breast cancer cells. The compounds of the subject invention also inhibit the phosphorylation of IKK-α/IKK-β, induce chromatin condensation, and/or induce DNA fragmentation in cancer cells. | 07-25-2013 |
20130183418 | METHOD OF INHIBITION OF ENZYMATIC BROWNING IN FOOD USING A SULFINIC ACID COMPOUND - A method of inhibiting enzymatic browning in food involves the contacting of a compound comprising a sulfinic acid with the food. The sulfinic acid comprising compound can be provided from solution, an extract, or in solid form to a food that can lose its appeal to a consumer due to browning, such as cut fruits and vegetables, seafood, or a beverage. The antibrowning agent can be applied to the food by spraying, dusting, dipping, or dissolving, depending upon the form of the food to which the agent is added. The compound comprising a sulfinic acid can comprise an alkysulfinic acid, an arylsulfinic acid, an alkylarylsulfinic acid, or an arylalkylsulfinic acid. | 07-18-2013 |
20130165614 | CATHODICALLY COLORING YELLOW SOLUBLE ELECTROCHROMIC AND LIGHT EMITTING POLYMERS - Embodiments of the invention are directed to yellow-to-transmissive conjugated polymers, a method to prepare the yellow conjugated polymers, the use of the yellow conjugated polymers in an electrochromic and/or electroluminescent device comprising neutral state primary subtractive colored conjugated polymers, and a method to prepare the device comprising the yellow conjugated polymer. The yellow conjugated polymers comprise a sequence of dioxythiophene units alternating with aromatic units, thiophene units, furan units, and/or pyrrole units. The yellow conjugated polymers are prepared by cross-condensation reactions. The yellow conjugated polymers can be soluble and preparation of the device involves deposition of the yellow conjugated polymer from solution onto a surface. | 06-27-2013 |
20130158940 | VESTIBULAR DYNAMIC INCLINOMETER - A method of determining orientation parameters of a rigid body ( | 06-20-2013 |
20130157330 | L-MALATE PRODUCTION BY METABOLICALLY ENGINEERED ESCHERICHIA COLI - A process for the production of malic acid in commercially significant quantities from the carbon compounds by genetically modified bacterial strains (GMBS; also referred to as biocatalysts or genetically modified microorganisms) is disclosed. Microorganisms suitable for the production of malic acid can be cultured in one or two-step processes as disclosed herein. | 06-20-2013 |
20130150552 | SOLUBLE ALTERNATING DONOR-ACCEPTOR CONJUGATED POLYMER ELECTROCHROMES - Embodiments of the invention are directed to alternating donor-acceptor (DA) polymers that are soluble and display a blue or green neutral state that oxidizes to a transmissive state for use as an electrochromic polymer. The D units have 3,4-dioxythiophene, 3,6-dialkoxythieno[3,2-b]thiophene or 3,5-dialkoxy-dithieno[3,2-b:2′,3′-d]thiophene groups. Embodiments of the invention are directed to a method for preparation of the alternating DA polymeric sequences of the DA polymers by a cross-condensation of a nucleophilic acceptor monomer and an electrophilic donor monomer. | 06-13-2013 |
20130139597 | WAVELENGTH DIVISION SENSING RF VIBROMETER FOR ACCURATE MEASUREMENT OF COMPLEX VIBRATIONS - Embodiments of the present invention provide a method for non-contact detection techniques of mechanical vibrations utilizing a radio frequency system incorporating multiple carrier wavelengths. The new detection method measures multiple harmonic pairs at a carrier frequency and improves the detection accuracy and reliability by first inspecting the Bessel function coefficient of each harmonic and then determining the harmonic amplitude. The original mechanical vibration can then be reconstructed. Embodiments can be used to realize sensing of complex non-sinusoidal vibrations using a wavelength division sensing technique and allow non-contact detection through walls, smoke, fog or other low visibility environments with the advantage of longer range detection and easy integration at a low cost. | 06-06-2013 |
20130137847 | POLY(DIHYDROFERULIC ACID) A BIORENEWABLE POLYETHYLENE TEREPHTHALATE MIMIC DERIVED FROM LIGNIN AND ACETIC ACID AND COPOLYMERS THEREOF - An embodiment of the invention is directed to a biorenewable thermoplastic, poly(dihydroferulic acid) (PHFA), which is an effective polyethylene terephthalate (PET) mimic. In another embodiment of the invention, a biorenewable thermoplastic copolymer, poly(dihydroferulic acid-co-ferulic acid) is an effective polystyrene mimic. The PHFA and the copolymer can be prepared by the homocondensation of acetyldihydroferulic acid or the copolymerization of acetyldihydroferulic acid with acetylferulic acid, which are monomers that can be synthesized from starting materials isolated from lignin, rice bran, or other biorenewable sources. | 05-30-2013 |
20130134263 | WINGLESS HOVERING OF MICRO AIR VEHICLE - Embodiments of the subject invention relate to an air vehicle and a power source. Embodiments can operate at reasonable power levels for hovering and withstanding expected wind gusts. Embodiments can have a diameter less than 15 cm. Embodiments can have one or more smooth (continuous curvature) surface and can be operated using electromagnetic and electrohydrodynamic principles. The wingless design of specific embodiments can allow operation with no rotating or moving components. Additional embodiments can allow active response to the surrounding flow conditions. The issue of low lift to drag ratio and degradation of airfoil efficiency due to the inability of laminar boundary layers attachment can also be significantly reduced, or eliminated. The electromagnetic force can be generated by applying a pulsed (alternating/rf) voltage between a set of grounded and powered electrodes separated by a polymer insulator, dielectric, or other material with insulating properties. | 05-30-2013 |
20130133934 | BIOCOMPATIBLE CONDUCTIVE INKS - This invention relates to compositions and methods related to biocompatible conductive inks. In a preferred embodiment the inks are printable onto biocompatible substrates and are used in the creation of biocompatible medical devices, in general, the inks comprise a plurality of particles. In one embodiment, the particles have a particle surface and an agent on the particle surface, the agent configured to prevent the particles from agglomerating when the particles are in a solution, the agent also configured to allow adjacent particle surfaces to be in contact when the particles are not in the solution due to an opening in the agent. | 05-30-2013 |
20130129633 | MULTIMODAL NANOPARTICLES FOR NON-INVASIVE BIO-IMAGING - Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging. | 05-23-2013 |
20130125667 | SYSTEM AND METHOD FOR ASSESSING THE PERFORMANCE OF AN ATTITUDE CONTROL SYSTEM FOR SMALL SATELLITES - Various embodiments of the present invention include systems and methods for assessing the performance of an actuator of an attitude control system (ACS), such as a control moment gyroscope (CMG). In one embodiment, a system includes a support bracket assembly coupled to an actuator, wherein the actuator is configured to generate an output torque. The system also includes at least one sensor assembly that includes a sensor configured to measure the output torque about at least one axis of the support bracket assembly while the support bracket assembly remains substantially motionless. | 05-23-2013 |
20130125254 | CITRUS TRISTEZA VIRUS BASED VECTORS FOR FOREIGN GENE/S EXPRESSION - Disclosed herein are viral vectors based on modifications of the Citrus Tristeza virus useful for transfecting citrus trees for beneficial purposes. Included in the disclosure are viral vectors including one or more gene cassettes that encode heterologous polypeptides. The gene cassettes are positioned at desirable locations on the viral genome so as to enable expression while preserving functionality of the virus. Also disclosed are methods of transfecting plants and plants transfected with viral vector embodiments. | 05-16-2013 |
20130118585 | NANOCRYSTALLINE COPPER INDIUM DISELENIDE (CIS) AND INK-BASED ALLOYS ABSORBER LAYERS FOR SOLAR CELLS - Embodiments of the invention are to a copper indium diselenide (CIS) comprising nanoparticle where the nanoparticle includes a CIS phase and a second phase comprising a copper selenide. The CIS comprising nanoparticles are free of surfactants or binding agents, display a narrow size distribution and are 30 to 500 nm in cross section. In an embodiment of the invention, the CIS comprising nanoparticles are combined with a solvent to form an ink. In another embodiment of the invention, the ink can be used for screen or ink-jet printing a precursor layer that can be annealed to a CIS comprising absorber layer for a photovoltaic device. | 05-16-2013 |
20130109680 | METHODS AND COMPOSITIONS FOR AMELIORATING THIAZIDE INDUCED HYPERLIPIDEMIA | 05-02-2013 |
20130108552 | NEAR-IR INDOCYANINE GREEN DOPED MULTIMODAL SILICA NANOPARTICLES AND METHODS FOR MAKING THE SAME | 05-02-2013 |
20130107039 | SYSTEMS AND METHODS FOR ESTIMATING POSE | 05-02-2013 |
20130106465 | SELF-POWERED COMPARATOR | 05-02-2013 |
20130098356 | METHODS OF USING CELLULASE FOR REDUCING THE VISCOSITY OF FEEDSTOCK - The invention provides methods for treatment of feedstock to reduce the relative viscosity and promote release of fermentable sugars. | 04-25-2013 |
20130095147 | SOL-GEL DERIVED BIOACTIVE GLASS POLYMER COMPOSITE - A bioactive sol-gel solution includes a biocompatible polymer, a gelable inorganic base material, and at least one calcium and phosphorous molecular species. The base material can be an alkoxide, such as TEOS. The polymer acts as a viscosity modifier to the sol or gel, increases the viscosity range over which fibers can be sprayed or spun, and broadens the time period over which fibers can be sprayed or spun. A bioactive glass composite can be formed from the bioactive sol-gel solution, including a fibrous form. Fibers can serve as a scaffolds for cell growth and in the repair of hard or soft tissue defects. | 04-18-2013 |
20130092229 | THIN FILM PHOTOVOLTAIC DEVICES WITH MICROLENS ARRAYS - Textured transparent layers are formed on the incident light receiving surface of thin film solar cells to increase their efficiency by altering the incident light path and capturing a portion of the light reflected at the MLA. The textured transparent layer is an array of lenses of micrometer proportions such as hemispheres, hemi-ellipsoids, partial-spheres, partial-ellipsoids, cones, pyramids, prisms, half cylinders, or combinations thereof. A method of forming the textured transparent layer to the light incident surface of the solar cell is by forming an array of lenses from a photocurable resin and its subsequent curing. The photocurable resin can be applied by inkjet printing or can be applied by roll to roll imprinting or stamping with a mold. | 04-18-2013 |
20130087200 | ENHANCED THIN FILM SOLAR CELL PERFORMANCE USING TEXTURED REAR REFLECTORS - Back reflector arrays are applied to the surface distal to the incident light receiving surface of a thin film solar cell to increase its efficiency by altering the reflected light path and thereby increasing the path length of light through the active layer of the solar cell. The back reflector is an array of features of micrometer proportions. The feature may be concave or convex features such as hemispheres, hemi-ellipsoids, partial-spheres, partial-ellipsoids, or combinations thereof The feature may be pyramidal. A method of forming the back reflector array is by forming an array of features from a photocurable resin, subsequent curing the resin and metalizing the cured resin to render the surface reflective. The photocurable resin can be applied by inkjet printing or rolling or stamping with a mold. | 04-11-2013 |
20130081324 | Fly Attractant System with Toxicant-Treated Cords - Systems, devices, apparatus and methods of attracting and capturing flies with toxicant treated darkened cords and printed or painted strips on sidewalls of housings. The darkened cords and strips black to confuse flies into believing they are cracks and crevices. Flies feed off the insecticide treated strips and are killed over time. At least one black line over a blue background can simulate a harborage to attract flying insects. At least one black line over a sticky surface card can be used. Geometrical housing shapes can include triangular, pentagon, cylindrical, rectangular, square, cube and/or other geometrical shapes. Housings can be tied off to be suspended. Second housings can be suspended beneath a main housing by attaching strips to the lower suspended housing. The housings can also work in an unassembled state where planar type sheets can be mounted on a wall. | 04-04-2013 |
20130080186 | Method, System, And Apparatus For Clinical Trial Management Over A Communications Network - A centralized, online clinical study system configured to coordinate aspects of a clinical study can include a training module configured to evaluate whether users have completed training for selected workflows for the clinical study that are available from the clinical study system, and to provide training to registered users for the selected workflows. The system also can include a financial engine configured to determine when a participating site meets or exceeds a milestone of the clinical study and to initiate a payment to the participating site. Further, the system can include a module configured to receive and verify clinical research data and to designate the verified clinical research data as official source data for the clinical study. | 03-28-2013 |
20130077434 | PLASMA INDUCED FLUID MIXING - Embodiments of the subject invention are directed to methods and apparatus for inducing mixing in a fluid using one or more plasma actuators. In an embodiment, a pair of electrodes is positioned near a fluid and a voltage potential is applied across the pair of electrodes such that a plasma discharge is produced in the fluid. In an embodiment, the plasma discharge creates turbulence in the fluid thereby mixing the fluid. In an embodiment, flow structures, such as vortices are generated in the fluid. In an embodiment, the fluid is mixed in three dimensions. In an embodiment, a plurality of fluids are mixed. In an embodiment, solids are dispersed in at least one fluid. In an embodiment, heat or other properties are dispersed within at least one fluid. In an embodiment, at least one of the pair of electrodes has a serpentine shape. | 03-28-2013 |
20130075382 | DIELECTRIC BARRIER DISCHARGE WIND TUNNEL - Embodiments of the subject invention are directed to methods and apparatus for inducing fluid flow in a wind tunnel using one or more plasma actuators. In an embodiment, a wind tunnel is provided having a flow passage. A pair of electrodes is positioned on at least one surface of the flow passage, and a voltage potential is applied across the pair of electrodes producing a plasma discharge in the flow passage. In an embodiment, the pair of electrodes is positioned on the at least one surface of the flow passage such that when the plasma discharge is produced an electrohydrodynamic (EHD) body force is generated that induces flow of a fluid in the flow passage. | 03-28-2013 |
20130074216 | TOMATO CATECHOL-O-METHYLTRANSFERASE SEQUENCES AND METHODS OF USE - The present disclosure provides isolated DNA molecules encoding tomato O-methyltransferases (OMT); tomato OMT proteins; OMT antisense molecules; vectors, plant cells and plants including tomato OMT DNA molecules or OMT antisense molecules; genetic markers for tomato OMT genes; and methods of increasing or decreasing the amount of guaiacol produced by a plant. | 03-21-2013 |
20130070753 | CONSISTENT UPDATES FOR PACKET CLASSIFICATION DEVICES - A method for managing incremental classifier tables is disclosed. A sequence of classifier table updates is received. Each update in the sequence of updates is associated with a filter and is analyzed. If multiple updates are received at the same time, then all updates associated with the same filter are identified. The updates on the same filter can be reduced to a single update resulting in an identical final state of the same filter. The other updates associated with the filter are removed from the sequence of updates. A reduced sequence of classifier updates is generated based on other updates of filters with multiple updates being removed. The reduced sequence of classifier updates comprises a set of classifier table updates, where for each distinct filter in the reduced sequence only one update is associated therewith. A reordered sequence of update operations is generated from the reduced sequence of update operations. | 03-21-2013 |
20130068045 | DYNAMIC WIND VELOCITY AND PRESSURE SIMULATOR - Various examples are provided for dynamic simulation of wind velocity and pressure. In one embodiment, among others, a dynamic wind simulator includes a fan and a fast-acting damper connected to an inlet of the fan. The fast-acting damper configured to modulate airflow provided by the fan at frequencies up to 10 Hz. In another embodiment, a system includes a fan and an air outlet path of the fan connected to a testing assembly configured to support a specimen for testing. An air inlet path of the fan includes a fast-acting damper configured to modulate airflow provided by the fan to the testing assembly at frequencies up to 10 Hz. The testing assembly may include a pressure chamber and/or a test section. | 03-21-2013 |
20130067909 | CURVED MULTIMORPH MICROACTUATORS THAT BEND AND/OR TWIST - A curved multimorph actuator is provided composed of a plurality of materials, each material exhibiting different deformations in response to a stimulus, such as heat. Application of different stimuli causes the actuator to bend and/or twist. In an embodiment, the actuator is capable of rotating an object about its center without significantly shifting the center in one or more dimensions. In a further embodiment, the actuator can be used to rotate an object about a first axis and a second axis, wherein the first axis and the second axis are mutually perpendicular. In an embodiment, rotation about the first axis and the second axis are achieved in combination. In another embodiment, rotation about the first axis is produced in response to a first stimulus and rotation about the second axis is produced in response to a second stimulus. | 03-21-2013 |
20130060056 | CATALYSTS, METHODS OF MAKING CATALYSTS, AND METHODS OF USE - Embodiments of the present disclosure provide for catalysts such as those shown in FIG. | 03-07-2013 |
20130052562 | COMPOSITE ANODE FOR A SOLID OXIDE FUEL CELL WITH IMPROVED MECHANICAL INTEGRITY AND INCREASED EFFICIENCY - A composite anode for a solid oxide fuel cell (SOFC), comprising an anode support layer (ASL) of Ni—YSZ and an anode functional layer (AFL) of Ni—GDC, displays enhanced mechanical stability and similar or improved electrical efficiency to that of a Ni—GDC ASL for otherwise identical SOFCs. A SOFC employing the composite anode can be used for power generation at temperatures below 700° C., where the composite anode may include a second AFL of GDC disposed between the Ni—GDC layer and a GDC electrolyte. | 02-28-2013 |
20130040901 | MITOCHONDRIAL-TARGETED ANTIOXIDANTS PROTECT AGAINST MECHANICAL VENTILATION-INDUCED DIAPHRAGM DYSFUNCTION AND SKELETAL MUSCLE ATROPHY - The present disclosure provides methods and compositions for preventing or treating MV-induced or disuse-induced skeletal muscle infirmities in a mammalian subject. The methods further include administering to the subject an effective amount of an aromatic-cationic peptide. | 02-14-2013 |
20130039858 | NIR MATERIALS AND NANOMATERIALS FOR THERANOSTIC APPLICATIONS - Novel fluorescent dye comprising metal oxide nanoparticles are prepared where the nanoparticles are as small as 3 nm or up to 7000 nm in diameter and where the dye is bound within the metal oxide matrix. In some embodiments the invention, novel dyes are covalently attached to the matrix and in other embodiments of the invention a dye is coordinate or ionic bound within the metal oxide matrix. A method for preparing the novel covalently bondable modified fluorescent dyes is presented. A method to prepare silica comprising nanoparticles that are 3 to 8 nm in diameter is presented. In some embodiments, the fluorescent dye comprising metal oxide nanoparticles are further decorated with functionality for use as multimodal in vitro or in vivo imaging agents. In other embodiments of the invention, the fluorescent dye comprising metal oxide nanoparticles provide therapeutic activity and incorporated therapeutic temperature monitoring. | 02-14-2013 |
20130038199 | SYSTEM, METHOD, AND APPARATUS FOR MICROSCALE PLASMA ACTUATION - A device is provided having a flow passage with at least one surface and at least one electrode pair positioned thereon for effecting fluid flow through the flow passage. When at least one electrode of an electrode pair of the at least one electrode pair is powered, a sheath region is generated in the flow passage, wherein the sheath region has a high electric field relative to the remainder of the flow passage. In an embodiment, one electrode of the electrode pair is separated from the other electrode of the electrode pair by a horizontal, vertical, depth, and/or total distance of about 1 microns. | 02-14-2013 |
20130035398 | FUNCTIONALIZED FULLERENES AS A BIOMASS STIMULANT AND A LIFE EXTENSION AGENT - Methods of stimulating an increase in biomass by stimulating the growth, lifespan and/or reproduction of organisms such as fungi, algae, plants, and other aquatic organisms are provided by applying an effective amount of functionalized fullerenes. For example, polyhydroxy fullerenes are effective at low levels of promoting the increase in biomass. | 02-07-2013 |
20130030028 | DESFERRITHIOCIN POLYETHER ANALOGUES - Compounds represented by structural formulas described herein, such as Structural Formula (I): | 01-31-2013 |
20130026371 | INDEX OF REFRACTION MATCHED NANOPARTICLES AND METHODS OF USE - Embodiments of the present disclosure provide for nanoparticles, methods of making nanoparticles, materials including nanoparticles, the use of materials including nanoparticles, and the like. | 01-31-2013 |
20130023823 | IMPLANTABLE THERAPEUTIC DEVICE AND METHODS OF MAKING - The subject invention pertains to an implantable therapeutic device for treating diabetes and methods of making. Upon implantation, the present device secretes insulin in response to blood glucose levels, exquisitely regulates blood glucose levels, reduces hyperglycemia, and includes β-cell regeneration in the host. It is useful for treating or ameliorating diabetes or diabetic conditions of a subject, including but not limited to, type 1 diabetes mellitus, hyperglycemia, impaired glucose tolerance, insulin deficiency, elevated glucose levels, and insulin resistance. | 01-24-2013 |
20130019937 | PHOTOVOLTAIC CELL ENHANCEMENT THROUGH UVO TREATMENT - Photovoltaic cells, methods of fabricating photovoltaic cells, and methods of using photovoltaic cells to capture light energy are provided. A photovoltaic cell can include an electron transporting layer, a photoactive layer, and a hole transporting layer. The electron transporting layer can be ultraviolet ozone treated. The photovoltaic cell can have an inverted configuration. | 01-24-2013 |
20130008509 | INVERTED POLYMER SOLAR CELL USING A DOUBLE INTERLAYER - A polymer based solar cell having an inverted geometry includes a transparent cathode and a double interlayer that has a hole extracting layer and a hole transport/electron blocking layer situated between an active layer, for example, a bulk heterojunction (BHJ) layer, and an anode. The inverted solar cells according to embodiments of the invention display significant efficiency improvements over polymer based solar cells that do not have the inverted geometry and lack the double interlayer. | 01-10-2013 |
20130001439 | INFRARED RADIATION FILTER SYSTEMS. METHODS OF USE, AND METHODS OF DISINFECTION AND DECONTAMINATION - In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to infrared (IR) filter systems, methods of using the IR filter systems, and methods of degrading a contaminant, and the like. | 01-03-2013 |
20120329947 | INTEGRATION OF PRECOATED NANOSTRUCTURES INTO BULK COMPOSITE MATRICES - Various methods and systems are provided for preparing a polymer nanocomposite. In one embodiment, among others, a method includes providing a first immiscible solution including an aqueous solution including polymer-coated nanoparticles and a first monomer and a second immiscible solution including an organic solution including a second monomer. The first and second immiscible solutions are in contact along an interface. A polymer nanocomposite, including the polymer-coated nanoparticles dispersed within the polymer matrix, is extracted from the interface. In another embodiment, a system includes a vessel and an extraction assembly. The vessel includes a first immiscible solution layer in contact with a second immiscible solution layer along an interface. The first immiscible solution layer includes an aqueous solution including polymer-coated nanoparticles and a first monomer. The second immiscible solution layer includes an organic solution including a second monomer. The extraction assembly is configured to extract the polymer nanocomposite from the interface. | 12-27-2012 |
20120329783 | COMPOSITIONS AND METHODS FOR SELECTIVE INHIBITION OF NICOTINE ACETYLCHOLINE RECEPTORS - The present invention concerns methods for treating or preventing neurological disorders characterized by dysfunction of nicotinic acetylcholine receptors by administering 2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH), or a pharmaceutically acceptable salt thereof, to the patient. In another aspect, the present invention pertains to pharmaceutical compositions containing TMPH, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. In another aspect, the present invention pertains to methods for selectively inhibiting nicotinic acetylcholine receptors that lack an α5, α6, or β3 subunit by contacting an effective amount of TMPH, or a pharmaceutically acceptable salt thereof, to the receptor. The method for selectively inhibiting nicotinic acethylcholine receptors that lack an α5 subunit can be carried out in vivo or in vitro. | 12-27-2012 |
20120319325 | CATHETER FOR ANTIMICROBIAL CONTROL AND METHOD OF MANUFACTURING THEREOF - Disclosed herein is a method comprising transporting a conduit and a template through a guide tube; the template being disposed on an outer surface of the conduit between the conduit and the guide tube; and transferring a texture from the template to the conduit as the conduit and the template are transported through the guide tube. Disclosed herein too is an apparatus comprising a guide tube; the guide tube being operative to facilitate a transfer of a pattern from a template to a conduit; a first feed spool and a first take-up spool for feeding the conduit through the guide tube and for taking up the conduit after it has travelled through the guide tube respectively; and a second feed spool and a second take-up spool for feeding the template through the guide tube and for taking up the template after it has travelled through the guide tube respectively. | 12-20-2012 |
20120317674 | HYBRID TOMATOES AND METHODS OF MAKING HYBRID TOMATOES - The present disclosure provides hybrid tomatoes that produce better-tasting fruit, methods of producing and identifying the hybrid tomatoes and methods of identifying the chemical composition of a tomato that leads to a better-tasting fruit. | 12-13-2012 |
20120314271 | METHOD AND APPARATUS FOR MODULATING LIGHT - Embodiments relate to a method and apparatus for producing polarized light, having a modulator crystal, where the modulator crystal incorporates a birefringent electro-optic material. The modulator crystal has an optic axis, a first polarization axis, and a second polarization axis, where the first polarization axis and second polarization axis are each perpendicular to the optic axis and perpendicular to each other. The apparatus can also include an electrode pair, where application of an electric field modulates light passing through the modulator crystal that is polarized along the first polarization axis. Embodiments pertain to a method and apparatus for modulating light. The apparatus incorporates a modulator crystal having an electro-optic material. The device also has at least two electrode pairs, where each electrode pair modulates light passing through the modulator crystal that has a direction of travel that has a component parallel to the optic axis. | 12-13-2012 |
20120300286 | Generation of Higher Harmonics of Monochromatic Electromagnetic Radiation - Various methods and systems are provided for generation of higher harmonics of monochromatic electromagnetic radiation. In one embodiment, among others, a system includes a double array of planar structures including a first periodically structured planar structure having a periodic spacing corresponding to a resonant frequency and a second periodically structured planar structure in parallel with the first structure. The system also includes a source configured to illuminate the first structure with a beam of monochromatic electromagnetic radiation at the resonant frequency to produce a higher harmonic of the monochromatic electromagnetic radiation. In another embodiment, a method includes directing a beam of monochromatic electromagnetic radiation at a resonant frequency at a double array of planar structures and generating a higher harmonic of the monochromatic electromagnetic radiation. The double array includes a first periodically structured planar structure and a second periodically structured planar structure in parallel with the first structure. | 11-29-2012 |
20120294903 | METHODS AND SYSTEMS OF MAKING NANOSTRUCTURES - In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making nanostructures (e.g., nanoparticles, nanofibers), systems for making nanostructures, and the like. | 11-22-2012 |
20120294891 | MATERIALS AND METHODS FOR DETECTING, PREVENTING, AND TREATING RETROVIRAL INFECTION - The subject invention pertains to materials and methods for detecting, preventing and treating retroviral infections in humans and other animals susceptible to infection by retrovirus. It has been discovered that FIV can be transmitted from cats to humans and that the FIV can infect human cells in vivo and that antibodies generated by the infected person cross-react with HIV antigens. Thus, the methods and compositions of the subject invention can be used to detect, prevent and treat FIV infection in humans and other non-feline animals that are susceptible to FIV infection. The methods and compositions of the invention can also be used to prevent and treat infection by HIV in humans. | 11-22-2012 |
20120294462 | AUTONOMOUS MIXER FOR DEVICES CAPABLE OF STORING AND PLAYING AUDIO SIGNALS - An apparatus and method for autonomously mixing multiple devices capable of storing and playing audio signals is provided. Multiple devices can be mixed into one standard stereo signal that can then be played on any sort of powered speakers or amplifier. The apparatus is capable of receiving multiple audio inputs and can combine multiple iPods®, iPhones®, MP3 devices, or other devices capable of storing and playing audio signals, such that more than one device can be played at one time. No human intervention is required to control the device when the device is in autonomous mode. The autonomous mode can include random song playback using multiple devices. | 11-22-2012 |
20120292262 | Apparatuses and Methods for Purifying Liquids - Disclosed are apparatuses and methods for purifying water. In some embodiments, the apparatuses include a chamber into which liquid to be purified can be delivered, and an ozone generator that generates ozone for mixture with the liquid in the chamber, the ozone generator comprising a surface discharge device that creates ozone from air. In further embodiments, the liquid is atomized into a fine mist and mixed with the ozone to increase the rate of purification. | 11-22-2012 |
20120289442 | ARTICLES HAVING LOW COEFFICIENTS OF FRICTION, METHODS OF MAKING THE SAME, AND METHODS OF USE - Embodiments of the present disclosure provide for articles, compositions, methods for making articles, methods of using articles, and the like. Embodiments of the present disclosure relate to articles having superior tribological properties. In particular, embodiments of the present disclosure have a low coefficient of friction and a very low wear rate relative to polytetrafluoroethylene (PTFE). | 11-15-2012 |
20120286296 | METHOD AND APPARATUS FOR SENSING INFRARED RADIATION - Embodiments of the invention pertain to a method and apparatus for sensing infrared (IR) radiation. In a specific embodiment, a night vision device can be fabricated by depositing a few layers of organic thin films. Embodiments of the subject device can operate at voltages in the range of 10-15 Volts and have lower manufacturing costs compared to conventional night vision devices. Embodiments of the device can incorporate an organic phototransistor in series with an organic light emitting device. In a specific embodiment, all electrodes are transparent to infrared light. An IR sensing layer can be incorporated with an OLED to provide IR-to-visible color up-conversion. Improved dark current characteristics can be achieved by incorporating a poor hole transport layer material as part of the IR sensing layer. | 11-15-2012 |
20120282456 | EPOXY RESIN COMPOSITES AND METHODS OF USE THEREOF - Embodiments of the present disclosure provide for epoxy resin composites, methods of making the epoxy nanocomposites, methods of using the nanocomposites, articles, methods of using articles, and the like. | 11-08-2012 |
20120280988 | INTERACTIVE MIXED REALITY SYSTEM AND USES THEREOF - An interactive mixed reality simulator is provided that includes a virtual 3D model of internal or hidden features of an object; a physical model or object being interacted with; and a tracked instrument used to interact with the physical object. The tracked instrument can be used to simulate or visualize interactions with internal features of the physical object represented by the physical model. In certain embodiments, one or more of the internal features can be present in the physical model. In another embodiment, some internal features do not have a physical presence within the physical model. | 11-08-2012 |
20120256175 | NANOTUBE ENABLED, GATE-VOLTAGE CONTROLLED LIGHT EMITTING DIODES - Embodiments of the invention relate to vertical field effect transistor that is a light emitting transistor. The light emitting transistor incorporates a gate electrode for providing a gate field, a first electrode comprising a dilute nanotube network for injecting a charge, a second electrode for injecting a complementary charge, and an electroluminescent semiconductor layer disposed intermediate the nanotube network and the electron injecting layer. The charge injection is modulated by the gate field. The holes and electrons, combine to form photons, thereby causing the electroluminescent semiconductor layer to emit visible light. In other embodiments of the invention a vertical field effect transistor that employs an electrode comprising a conductive material with a low density of states such that the transistors contact barrier modulation comprises barrier height lowering of the Schottky contact between the electrode with a low density of states and the adjacent semiconductor by a Fermi level shift. | 10-11-2012 |
20120252213 | CHEMICAL MECHANICAL POLISHING OF GROUP III-NITRIDE SURFACES - A method of chemically-mechanically polishing a substrate having a Group III-nitride surface includes providing a chemical-mechanical polishing slurry composition. The slurry composition includes a slurry solution including a liquid carrier and an oxidizer including a transition metal or a per-based compound. The slurry solution includes at least one component that reacts with the Group III-nitride surface to form a softened Group III-nitride surface. The Group III-nitride comprising surface is contacted with the slurry composition by a pad to form the softened Group III-nitride surface. The pad is moved relative to the softened Group III-nitride surface, wherein at least a portion of the softened Group III-nitride surface is removed. | 10-04-2012 |
20120237563 | CONTROLLED-RELEASE FORMULATIONS OF ANABASEINE COMPOUNDS AND USES THEREOF - The subject invention pertains to controlled-release dosage forms of anabaseine compounds, such as 3-(2,4-dimethoxybenzylidene)-anabaseine (also known as DMXBA or GTS-21) or a pharmaceutically acceptable salt thereof, methods of use, and methods for producing controlled-release dosage forms. | 09-20-2012 |
20120235855 | ADVANCED LOW POWER PERSONNEL/VEHICLE DETECTING RADAR - Embodiments of the subject invention relate to a method and apparatus for signal processing that reduces the average power used in a small size, frequency modulated continuous-wave (FMCW) radar. Such a small size, frequency modulated continuous-wave (FMCW) radar is referred to herein as a micro radar. Specific embodiments of the invention can be used to detect and/or track personnel, vehicle, and/or other targets. | 09-20-2012 |
20120234981 | Split Flywheel Assembly With Attitude Jitter Minimization - Various embodiments of the present invention include assemblies and methods for minimizing the amplitude of attitude jitter. In one embodiment, a split flywheel assembly includes a plurality of independent concentric flywheels axially aligned and in operable engagement with one another such that each flywheel is configured to be independently controlled in order to manipulate the phase difference therebetween. | 09-20-2012 |
20120231366 | POROUS CERAMIC MOLTEN METAL COMPOSITE SOLID OXIDE FUEL CELL ANODE - A fuel cell anode comprises a porous ceramic molten metal composite of a metal or metal alloy, for example, tin or a tin alloy, infused in a ceramic where the metal is liquid at the temperatures of an operational solid oxide fuel cell, exhibiting high oxygen ion mobility. The anode can be employed in a SOFC with a thin electrolyte that can be a ceramic of the same or similar composition to that infused with the liquid metal of the porous ceramic molten metal composite anode. The thicknesses of the electrolyte can be reduced to a minimum that allows greater efficiencies of the SOFC thereby constructed. | 09-13-2012 |
20120225413 | REAL-TIME FEEDBACK OF TASK PERFORMANCE - A method of providing real-time feedback of task performance includes receiving sensor data from sensors coupled to an object. The sensor data is received in response to tasks performed on the object and references positional data with respect to a location on the object at which tasks are performed. The method also includes applying the sensor data to a model of performance measurements, which reflect a standard of performance. The method further includes identifying any deviations of the sensor data from data in the model, and outputting feedback in real-time. The feedback includes indicators signaling tasks performed are correctly implemented and indicators signaling tasks performed are incorrectly implemented. Corrective indicators include measures for modifying task performance to achieve an outcome that approaches or meets the standard of performance. The indicators correspond to one or more locations on the object as determined by the positional data. | 09-06-2012 |
20120225270 | FABRICATION OF DUAL STRUCTURE CERAMICS BY A SINGLE STEP PROCESS - The subject invention discloses a method for the preparation of a dual structure cellular ceramic object where a dispersion of a ceramic precursor a chain-growth or step-growth polymer precursor and a solvent is heated to a first temperature at a first rate followed by heating to a second temperature at a second rate and holding the temperature to form a sintered dual structure cellular ceramic object which is then cooled at a third rate to room temperature. The dual structure cellular ceramic object has a dense surface layer over at least a portion of the object that abruptly yet smoothly and continuously transitioning into a porous ceramic. | 09-06-2012 |
20120217477 | UP-CONVERSION DEVICE WITH BROAD BAND ABSORBER - Embodiments of the invention are directed to an IR photodetector that broadly absorbs electromagnetic radiation including at least a portion of the near infrared (NIR) spectrum. The IR photodetector comprises polydispersed QDs of PbS and/or PbSe. The IR photodetector can be included as a layer in an up-conversion device when coupled to a light emitting diode (LED) according to an embodiment of the invention. | 08-30-2012 |
20120216870 | INTERLAYER FOR ORGANIC SOLAR CELLS - An organic PV solar cell that has an anode double interlayer situated between an electrode and an organic photoactive layer displays superior power conversion efficiency over that of equivalent devices with an anode single interlayer. The anode double layer can comprise a hole extraction layer adjacent to the anode and an organic hole accepting electron blocking material layer that comprises an aromatic amine compound with a plurality of N atoms. The hole extraction layer can be a metal oxide or an n-type organic semiconductor. | 08-30-2012 |