Universite Laval Patent applications |
Patent application number | Title | Published |
20160121491 | FORCE LIMITING DEVICE AND METHOD - The present invention relates to a method and apparatus for limiting the contact force between a moving device and another object, using a parallel mechanism and torque limiters where the threshold force to activate the force limiting mechanism is not related to the configuration of the moving device or the location of the contact force relative to the activation point of the force limiting mechanism, and where the mechanism may be configured for one, two or three degrees of freedom. A counterbalance mechanism is also provided to counteract gravity load when the force limiting mechanism is configured for three degrees of freedom and responsive to contact forces including a vertical element. In particular, the invention relates to a method and apparatus for limiting the contact force between a moving robotic device and a contactable object. | 05-05-2016 |
20160103227 | LARGE-VOLUME SCINTILLATOR DETECTOR FOR RAPID REAL-TIME 3-D DOSE IMAGING OF ADVANCED RADIATION THERAPY MODALITIES - An apparatus and method for measuring three-dimensional radiation dose distributions with high spatial and temporal resolution using a large-volume scintillator. The scintillator converts the radiation dose distribution into a visible light distribution. The visible light is transported to one or more photo-detectors, which measure the light intensity. The light signals are processed to correct for optical artifacts, and the three-dimensional light distribution is reconstructed. The reconstructed light distribution is post-processed to convert light amplitudes to measured radiation doses. The high temporal resolution of the detector makes it possible to observe the evolution of a dynamic dose distribution as it changes over time. Integral dose distributions can be measured by summing the dose over time. | 04-14-2016 |
20160046587 | PREPARATION AND METHOD FOR USE IN THE TREATMENT OF RESPIRATORY DISEASES - The present disclosure relates to a novel active compound having the formula Ia: | 02-18-2016 |
20160039093 | LOW-IMPEDANCE ARTICULATED DEVICE AND METHOD FOR ASSISTING A MANUAL ASSEMBLY TASK - A system for assisting an operator in a manual assembly task includes a base assembly, end-effector, and controller. The base assembly has joint actuators providing three or more degrees of freedom (DOF). The end-effector is in series with the base assembly and has additional joints providing one or more additional DOFs. The base assembly and end-effector support a task load, including a weight and/or a reaction torque of an object. Sensors measure joint positions. The controller receives the measured positions, controls the joint actuators to support the task load, and extends a range of motion of the object. A method includes receiving the position signals as the operator manipulates the object, generating an output signal using the measured positions, and transmitting the output signal to the joint actuators to control the joint actuators, support the task load, and extending a range of motion of the object. | 02-11-2016 |
20150267762 | Magnetorheological Flight Control Clutch System - In some embodiments, a redundant control system includes first and second control systems, having first and second clutches, and a shared clutch system. The shared clutch system may include a shared shaft configured to receive mechanical energy from a shared power source, a first shared clutch corresponding to the first clutch and configured to receive mechanical energy from the shared shaft, and a second shared clutch corresponding to the second clutch and configured to receive mechanical energy from the shared shaft. A first linkage provides mechanical communication between an output of the first clutch, an output of the first shared clutch, and a first output device in mechanical communication with the rotor system. A second linkage provides mechanical communication between an output of the second clutch, an output of the second shared clutch, and a second output device in mechanical communication with the rotor system. | 09-24-2015 |
20150114165 | FORCE LIMITING DEVICE AND METHOD - The present invention relates to a method and apparatus for limiting the contact force between a moving device and another object, using a parallel mechanism and torque limiters where the threshold force to activate the force limiting mechanism is not related to the configuration of the moving device or the location of the contact force relative to the activation point of the force limiting mechanism, and where the mechanism may be configured for one, two or three degrees of freedom. A counterbalance mechanism is also provided to counteract gravity load when the force limiting mechanism is configured for three degrees of freedom and responsive to contact forces including a vertical element. In particular, the invention relates to a method and apparatus for limiting the contact force between a moving robotic device and a contactable object. | 04-30-2015 |
20150110774 | S100 PROTEIN INHIBITORS FOR TREATING LEUKEMIA - The present invention relates to a compound, composition and method for reducing or inhibiting the differentiation or development of progenitor blood cells into malignant cells, leukemia cells or physiologically pathological cells. Particularly, the invention describes the use of inhibitors of S100 proteins, including myeloid related proteins. Inhibition of the activity or synthesis of S100 proteins results into reduction or inhibition of the production or proliferation of aberrant and cancer blood cells. | 04-23-2015 |
20150110149 | METHOD AND APPARATUS FOR DETERMINING AN ICING CONDITION STATUS OF AN ENVIRONMENT - The method includes receiving a value of a quantity of heat applied to at least a portion of a structure, said structure having a sensor surface exposed to the environment, receiving a temperature measurement of the sensor surface, receiving a wind speed measurement of the environment, receiving an ambient temperature measurement of the environment, determining a heat transfer projection of the sensor area using at least the wind speed measurement, the ambient temperature measurement, and one of the value of a quantity of heat and a target temperature of the sensor surface; comparing the heat transfer projection to an associated heat transfer value, and generating a signal indicating the icing condition status based on the comparison. | 04-23-2015 |
20150080443 | NOVEL FORMULATIONS FOR THE TREATMENT OF VAGINAL DISORDERS - The present disclosure provides novel formulations suitable for the intravaginal delivery of tinidazole, as well as methods of using the same. | 03-19-2015 |
20140378502 | Par1 Inhibitors for Use in the Treatment or Prevention of Paramyxoviridae Infections - The present invention is concerned with the use of Protease-Activated Receptor-1 (PAR1) inhibitors for preventing or treating a Paramyxoviridae infection in a subject. Described herein are methods, compounds and pharmaceutical compositions useful in addressing such infections, and more particularly infections from human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV). | 12-25-2014 |
20140371409 | PREPARATION OF HIGH MOLECULAR WEIGHT POLYMERS BY DIRECT ARYLATION AND HETEROARYLATION - A method for preparing polymers by direct heteroarylation or arylation polycondensation is described herein. The method includes preparing a reaction mixture including at least a monomer to be polymerized, a catalyst and a ligand; heating the reaction mixture, and, optionally, end-capping the reaction mixture. | 12-18-2014 |
20140350303 | CATALYSTS FOR THE PRODUCTION OF METHANOL FROM CARBON DIOXIDE - Catalysts for the reduction of CO | 11-27-2014 |
20140341927 | ANTIBODIES AND THEIR USE IN THE TREATMENT, PREVENTION AND DIAGNOSIS OF A DISEASE ASSOCIATED WITH SOD1 ABNORMALITIES - The present invention concerns an antibody which specifically binds to an abnormal superoxide dismutase 1 (SOD1), and which neutralizes its pathologic effect when administered to an animal such as a human. The antibody of the invention is a monoclonal antibody produced by hybridoma cell lines deposited with the International Depositary Authority of Canada on Aug. 29, 2006 under accession numbers ADI-290806-01, ADI-290806-02 and ADS-290806-03. The present invention also concerns the use of the antibody of the invention in the treatment, prevention and diagnosis of neurodegenerative diseases such as Amyotrophic lateral sclerosis, Parkinson and Alzheimer in an animal such as a human. | 11-20-2014 |
20140315968 | Substituted 2-Imidazolidinones and 2-Imidazolones and Their Use in the Treatment of Cancer - Compounds of formula (I) wherein R | 10-23-2014 |
20140263991 | METHODS AND APPARATUS FOR OPTICALLY ENCODED POSITION MULTIPLE-POINT SCINTILLATION DETECTOR USING A SINGLE COLLECTING LIGHT GUIDE - Various embodiments are described herein for a radiation dosimetry apparatus and associated methods for measuring radiation dose. In some embodiments, the apparatus includes multiple scintillating elements for detecting amounts of radiation dose at multiple points within a detection region. Each of the scintillating elements generates light in response to radiation interacting within their volume. A light guide combines the light generated by all of the scintillating elements as well as radiation-induced contaminated optical energy and transmits the combined light to a spectral analysis setup. Multi or hyper-spectral calibration technique allows calculating the dose or dose rate at the positions of the different scintillating elements. The calibration technique isolates the light produced by a given scintillating element from the other scintillating elements as well as any other source of radiation-induced contaminating light. | 09-18-2014 |
20140206572 | OVARIAN MARKERS OF FOLLICULAR MATURITY AND USES THEREOF - The present invention relates to field of fertility. The invention identifies biological ovarian markers from follicular cells, from follicular fluid, from cumulus cells and from oocytes which are indicative of follicular maturity in mammals. Described are methods for improving ovarian stimulation, methods for assessing maturity of a mammalian ovarian follicle, methods for optimizing in vitro maturation (IVM) and methods for classifying an embryo, these methods being based on assessment of expression level of ovarian markers indicative of maturity. Also described are methods for screening compounds stimulatory of or inhibitory to mammalian follicular maturation, kits for evaluating follicular maturity. | 07-24-2014 |
20140204458 | POLARIZATION-MAINTAINING MODULE FOR MAKING OPTICAL SYSTEMS POLARIZATION-INDEPENDENT - Polarization compensation in optical system having a primary optical element having polarization-altering characteristics, such as a dichroic element, is provided. A compensation optical element having substantially the same polarization-altering characteristics as the primary optical element is provided in the path of the light beam whose polarization state is to be conserved. The compensation optical element is oriented with respect to the light beam such that by transmitting or reflecting the light beam, it alters its polarization state in a manner opposite to the altering of this polarization state by the primary optical element. Advantageously, this is true for any orientation of the polarization state of the light beam. | 07-24-2014 |
20140178361 | METHOD FOR POLYCLONAL IMMUNOGLOBULIN G PRODUCTION BY HUMAN B CELLS - This application relates to an in vitro method of producing a polyclonal IgG preparation. The method comprises (i) placing a polyclonal B-cell population enriched in IgG-secreting B cells in a culture medium; and (ii) culturing the polyclonal B-cell population under conditions enabling the production of the polyclonal IgG preparation from the polyclonal B-cell population. This improved method enables the production of antibodies (preferably IgG) and facilitates long-term culture of polyclonal B-cell populations. | 06-26-2014 |
20140158124 | METHOD AND SYSTEM FOR THE DELIVERY OF CARBON DIOXIDE TO A PATIENT - A method and system for delivering a gas containing carbon dioxide to a patient are described. The method comprises measuring a physiological parameter of breathing stability in the patient; determining an optimal gas delivery parameter based on the physiological parameter of breathing stability; and delivering the gas to the patient in accordance with the optimal gas delivery parameter. | 06-12-2014 |
20140126790 | QUALITY CONTROL AND ASSURANCE OF IMAGES - Applicants have discovered a multi-layer quality control/quality assurance system that provides higher quality data, without human intervention, by rejecting images that do not achieve a pre-determined quality threshold. In some embodiments of the present invention, there is provided a new method of processing an image from a data set through a pipeline wherein quality control/assurance allows to determine a quality of the image processing, the method comprising; receiving a test image; pre-processing the test image; registering the test image to a reference image; calculating a test image quality using a correlation of image intensity values between corresponding locations of the test image and the reference image; providing a plurality of training images and calculating training image quality distribution statistics for the training images with respect to the reference image; and relating the test image quality to the training image quality distribution. | 05-08-2014 |
20140120562 | METHODS FOR THE PROGNOSTIC AND/OR DIAGNOSTIC OF NEURODEGENERATIVE DISEASE, METHODS TO IDENTIFY CANDIDATE COMPOUNDS AND COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASE - The present invention provides methods and uses for the diagnostic of a subject predisposed or suspected of developing a neurodegenerative disease or suffering from a neurodegenerative disease. The present invention also relates to methods and uses for identifying candidate compounds and to compounds for treating neurodegenerative disease. The present invention also relates to an animal model for neurodegenerative disease. | 05-01-2014 |
20140088053 | INHIBITORS OF 17Beta-HSD1, 17Beta-HSD3 AND 17Beta-HSD10 - The present application discloses 17β hydroxy steroid dehydrogenase (17β HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17β HSD1 inhibitors include estradiol derivatives with a nieta-carbamoylbenzyl substituent at C 16. 17β HSD3/HSD10 inhibitors include androsterone derivatives substituted at the C3 position with a sulfonamide piperazine. Also disclosed are compounds that are inhibitors of both 17β HSD1 and 17β HSD3 that have a spiro-morpholine substituent at C20. | 03-27-2014 |
20140073694 | CYSTAMINE ANALOGUES FOR THE TREATMENT OF PARKINSON'S DISEASE - The present invention relates to the use of cystamine analogues for the treatment of Parkinson's disease. The present invention also relates to the use of composition comprising cystamine analogues and cysteine. The present invention relates to a method for modifying the progression of Parkinson's disease comprising administering a therapeutically effective amount of at least one cystamine analogue or a pharmaceutically acceptable salt of a cystamine analogue to a patient in need thereof. | 03-13-2014 |
20140051737 | METHODS FOR THE TREATMENT AND DIAGNOSTIC OF PULMONARY ARTERIAL HYPERTENSION - The present application relates to the use at least one PARP inhibitor or a pharmaceutically acceptable salt thereof for the treatment of Group 1 pulmonary arterial hypertension (PAH) in a subject, including a human, in need of such treatment. There is also provided methods of treating and diagnosing Group 1 pulmonary arterial hypertension (PAH). | 02-20-2014 |
20140031605 | Method and Use of Peripheral Theta-Burst Stimulation (PTBS) for Improving Motor Impairment - The present invention provides new evidences to support that repetitive peripheral magnetic stimulation (theta-burst en stimulation, TBS) over nerve/muscle improves sensorimotor control. Chronic low back pain (CLBP) is associated to a faulty volitional activation of transversus abdominis muscle (TrA) and its delayed contraction during anticipatory postural adjustment (APA), in correlation with maladaptive reorganization of primary motor cortex (M1). Repetitive magnetic stimulation of nerves can influence brain excitability and even reduce rigidity (Parkinson's disease), spasticity (stroke, ABI, cerebral palsy), and contribute to improvement of motor-control and function in stroke, chronic low back pain, ABI, cerebral palsy, prematurity and Parkinson's disease. We hereby test—for the first time—the after-effects of TBS applied over nerves or muscles (peripheral TBS, PTBS) on the motor abdominal-function of chronic low back pain sufferers and on the foot function of brain-injured subjects and to adjust TBS protocol per subject relative to the clinical profile. These pilot studies demonstrate the long-term influence of peripheral neurostimulation in chronic pain, rigidity and spasticity associated to motor impairment. | 01-30-2014 |
20130324545 | METHODS FOR THE REGULATION OF THE PROSTAGLANDIN F SYNTHASE (PGFS) ACTIVITY OF AKR1B1 AND USES THEREOF - AKR1B1 (EC 1.1.1.21) is an aldose reductase that has mainly been associated with the polyol pathway, and more recently with lipid deperoxidation. We have discovered that the primary activity of this enzyme is rather a PGFS activity, catalyzing the transformation of PGH | 12-05-2013 |
20130304409 | METHODS FOR VALIDATING PLASTIC SCINTILLATING DETECTORS AND APPLICATIONS OF SAME - According to one aspect, methods for validating plastic scintillating detectors (PSD) for photon dosimetry and applications of same. In some embodiments, the method includes using at least one PSD to obtain at least one dose measurement, determining at least one PSD correction factor suitable for compensation for variations in energy response of the at least one PSD over the energy range of interest, and determining at least one corrected dose measurement based on the at least one PSD correction factor. In some embodiments, the PSD may be incorporated into a wearable article, such as gloves, eyewear and the like, or used for skin surface measurements. | 11-14-2013 |
20130273075 | Compounds and Method for Modulating Inflammatory Reactions - The present invention relates to compounds and methods for modulating, reducing or inhibiting, inflammatory reactions in a patient. Particularly, inflammatory reactions that are targeted by the present invention are cell migration, secretion of toxic products and proteolysis at a site of inflammation. Reduction of inflammation manifestations and reactions occurs by using an anti-S100 polynucleotide or polypeptide inhibitor or antagonist, which is essentially targeted against S100A8, S100A9 or S100A12, alone or in combination with other inhibitors of chemokines or immune modulating products. | 10-17-2013 |
20130267461 | COMPOUNDS AND THERAPEUTIC APPLICATIONS RELATED TO INHIBITION OF DENDRITIC CELL IMMUNORECEPTOR (DCIR) ACTIVITY AND SIGNALING EVENTS - The invention is concerned with methods, compounds and pharmaceutical compositions for interfering dendritic cell immunoreceptor (DCIR) activity and signalling events. Described herein are compounds useful in targeting one or more of intracellular modulators and the uses thereof for the prevention or treatment of virus infections, and more particularly for reducing human immunodeficiency virus (HIV) binding, entry and/or replication in human cells. Exemplary compounds include peptides and antisense molecules. | 10-10-2013 |
20130253702 | METHOD OF INFERRING INTENTIONS OF AN OPERATOR TO MOVE A ROBOTIC SYSTEM - A method of inferring intentions of an operator to move a robotic system includes monitoring the intention of the operator, with a controller. The intention of the operator is inferred to be one of a desired acceleration and a desired deceleration. The intention of the operator is also as a desired velocity. Admittance parameters are modified as a function of at least one of the inferred acceleration, deceleration, and velocity. | 09-26-2013 |
20130202407 | Oscillating Hydrofoil, Turbine, Propulsive System and Method for Transmitting Energy - System and method for converting kinetic energy from a fluid flow into mechanical energy, the method comprising the steps of: a) providing a turbine including first and second hydrofoils, each of the hydrofoils being able to move lin-early in a heaving motion, and being able to oscillate about a spanwise axis in a pitching motion, said heaving and pitching motions being quasi-si-nusoidal, b) coupling the heaving motions of the first and second hydrofoils to the pitching motions of the second and first hydrofoils respectively, with the pitch-heave motion phase being substantially equal to the inter-hydrofoil phase, the heaving motion of one of the hydrofoils thereby driving the pitching motion of the other hydrofoil; and c) transforming the heaving motions of the hydrofoils into a rotational movement of a rotatable shaft, with linear-to-rotary transmission means. | 08-08-2013 |
20130149703 | "MARKERS FOR PROSTATE CANCER PROGRESSION" - Purpose. The relationship between inherited genetic variations in 5α-reductase type 1 (SRD5A1) and type 2 (SRD5A2) genes and the risk of biochemical recurrence after radical prostatectomy (RP) in prostate cancer (PCa) remains a fairly unexplored area of research. Patients and Methods. We studied 526 men with organ-confined and locally advanced PCa with a median follow-up time of 7.4 years. We investigated the effects of allelic variants of SRD5A1 and SRD5A2 genes and haplotype-tagging single nucleotide polymorphisms (htSNPs; n=19) on recurrence-free survival after RP using Kaplan-Meier plots, the log-rank test, and Cox proportional hazard models. Results. Upon adjusting for known prognostic clinical and pathological factors, eight htSNPs were shown to be independent predictors of recurrence. The SRD5A1 rs166050 polymorphism was associated with an increased recurrence risk of HR=1.83 (95% CI, 1.04-3.21; P=0.035), while the rs518673 in SRD5A1 was associated with a decreased risk (HR=0.59, 95% CI, 0.41-0.85; P=0.004). The SRD5A2 gene was strongly associated with the risk of relapse with six polymorphisms being positively associated with recurrence including the known SRD5A2 V89L (rs523349) (HR=2.14, 95% CI, 1.23-3.70; P=0.007) and a protective htSNP rs12470143 with a HR of 0.66, (95% CI, 0.46-0.95; P=0.023). By combining SRD5A1 (rs518673T) and SRD5A2 (rs12470143 A), the protective effect was shown to be additive with the maximum protection conferred by 3 or 4 alleles (HR=0.33, 95% CL 0.17-0.63; P=0.001). Conclusion. Germline polymorphisms in 5α-reductase genes are independent prognostic genetic biomarkers that predict PCa biochemical recurrence after radical prostatectomy and may represent useful molecular tools for a genotype-tailored clinical approach. | 06-13-2013 |
20130147071 | Method for Writing High Power Resistant Bragg Gratings Using Short Wavelength Ultrafast Pulses - A method for writing a Bragg grating in a glass optical waveguide is provided. Ultrafast optical pulses are generated, preferably in the femtosecond range and having a writing wavelength in the range of 300 nm to 700 nm and an intensity sufficient to induce a change of refractive index in the waveguide through densification. The optical pulses are diffracted using a phase mask, to generate an interference pattern having a pitch providing a fundamental Bragg resonance corresponding to the target wavelength to be reflected by the grating. The interference pattern is impinged on a region of the waveguide, which is heated to a temperature above a threshold and for a predetermined heating period. Advantageously, the heating step allows the reduction of photoinduced losses which would otherwise be present in the waveguiding properties of the waveguide. Optionally, gratings may be written through the polymer jacket of an optical fiber. | 06-13-2013 |
20130112645 | PASSIVELY ACTUATED BRAKING SYSTEM - A movement system includes a rail, a trolley, and a braking system. The trolley is movably attached to the rail and configured to support the payload. The braking system is operatively attached to the rail. The braking system includes a braking module having a base, operatively attached to the trolley, and a wheel assembly, operatively attached to the base. The wheel assembly has a shaft, a clutch, and a braking wheel. The clutch is rigidly attached to the shaft and configured for rotation with the shaft about the rolling axis. The braking wheel axially surrounds the clutch and is in continuous rolling contact with a surface of the rail. The clutch is configured to selectively allow rotation of the braking wheel relative to the shaft in only one direction of rotation to decelerate movement of the trolley along the rail. | 05-09-2013 |
20130112644 | MOVEMENT SYSTEM CONFIGURED FOR MOVING A PAYLOAD - A movement device is moved along an X axis and a Y axis by providing a sensor configured to measure angle of rotation of at least one of a first and a second kinematic link about a respective axis of rotation. A force is imparted on the first and second kinematic links such that an angular displacement of the first and second kinematic links about the respective axis of rotation is achieved. The angular displacement of the first and second kinematic links about the respective axis of rotation is determined. The movement device is moved along the X axis and/or the Y axis in response to the determination of the angle of rotation of the first and second kinematic links about the respective axis of rotation until first and second kinematic links are vertical. | 05-09-2013 |
20130112643 | MOVEMENT SYSTEM CONFIGURED FOR MOVING A PAYLOAD IN A PLURALITY OF DIRECTIONS - A movement system includes a bridge crane, a trolley, and a movement device. The movement device includes an attachment portion, a plurality of housings, first and second curved elements, a cable, and a cable angle sensor. The curved elements are pivotally attached to housings and perpendicularly overlap with one another such that a first slot defined in the first curved element is perpendicular to a second slot defined in the second curved element. The first curved element is pivotable about a first axis and the second curved element is configured to pivot about a second axis. The cable extends from the attachment portion and through each of the slots. The cable is pivotable to angularly displace at least one of the curved elements about a respective axis. The cable angle sensor is configured to measure the angular displacement of the at least one of the first and second curved elements. | 05-09-2013 |
20130112641 | GRAVITY POWERED BALANCING SYSTEM - A balance assist system includes a support structure, an assist device, a variable balancing system, and a balancing cable. The variable balancing system is configured for moving a mass in a vertical direction along a Z axis. The variable balancing system includes a balance platform, a lever, and a mobile counterweight. The lever is pivotally attached to the balance platform at a fixed pivot point such that the lever is pivotable at the fixed pivot point about a balance axis. The mobile counterweight is movably disposed on the lever relative to the fixed balance axis and movable between a minimum position and a maximum position. The minimum position corresponds to the mass having a minimum weight such that the mass is statically balanced along the Z axis. Likewise, the maximum position corresponds to the mass having a maximum weight such that the mass is statically balanced along the Z axis. | 05-09-2013 |
20130101189 | System and Method for Medical Image Intensity Standardization - Intensity standardization of MRI data sets aims at correcting scanner-dependent intensity variations. An automatic technique, called STI, which shares the simplicity and robustness of histogram-matching techniques, but also incorporates tissue spatial intensity information, has been discovered. The method comprises registering a medical image to a standard image; applying one or more masks to the image medical and standard images for isolating certain specific image components; determining the most common intensity data pair between the medical and standard images for each isolated image component; calculating a formula that joins the most common intensity data pair of each image component; and interpolating an intensity data adjustment using the formula and applying it to the medical image data to generate a standardized version of the medical image. | 04-25-2013 |
20130090303 | Agonists of PY2Y Receptor as a Treatment for Aortic Stenosis and Cardiovascular Calcification - The present invention relates to the treatment and/or prevention of aortic valve stenosis (AVS) and valve mineralization. Particularly, the invention provides a target for intervention in the treatment or prevention of AVS through the administration of the P2Y | 04-11-2013 |
20130076902 | ROBOTICALLY OPERATED VEHICLE CHARGING STATION - A robotic charging station for charging a battery of an electric vehicle includes a base plate, a riser coupled with the base plate and extending substantially transverse to the base plate, and a robotic arm. The robotic arm extends from the riser and supports an end effector. The end effector includes a plurality of electrical contacts configured to couple with a receptacle disposed on the electric vehicle. The robotic arm is configured to move the end effector in three degrees of motion. | 03-28-2013 |
20130048075 | NOVEL PHOTOACTIVE POLYMERS - Photoactive polymers comprising first and second co-monomer repeat units, the first co-monomer repeat unit comprising a moiety selected from the group consisting of an alkylthieno[3,4-c]pyrrole-4,6-dione moiety and a 1,3-dithiophene-5-alkylthieno[3,4-c]pyrrole-4,6-dione moiety, and the second co-monomer repeat unit comprising a moiety selected from the group consisting of a 4,4′-dialkyl-dithieno[3,2-b:2′3′-d]silole moiety, an ethylene moiety, a thiophene moiety, an N-alkylcarbazole moiety, an N-(1-alkyl)dithieno[3,2-b:2′3′-d]pyrrole moiety and a 4,8-dialkyloxylbenzo[1,2-b:3,4-b]dithiophene moiety are described herein. These polymers are suitable for use in photovoltaic cells and field effect transistors. | 02-28-2013 |
20120309777 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS - Compounds of formula (I): wherein R | 12-06-2012 |
20120195923 | USE OF SKIN CARE COMPOSITIONS COMPRISING LAMINARIACEA EXTRACT FOR TREATMENT OF SKIN AGING SIGNS - This invention is directed to a skin care composition comprising a laminriacea (brown seaweed) extract and the use of said composition in the treatment of skin aging signs Specifically, it was discovered that a crude extract of the laminariacea | 08-02-2012 |
20120164636 | MAMMALIAN OOCYTE DEVELOPMENT COMPETENCY GRANULOSA MARKERS AND USES THEREOF - The present invention relates to the competence of oocytes to uterine implantation and development into living individual. The invention more particularly relates to marker that are detected and measured in granulosa cells collected along with the oocytes during oocyte aspiration as it is done in assisted reproduction techniques. | 06-28-2012 |
20120128301 | Method For Writing High Power Resistant Bragg Gratings Using Short Wavelength Ultrafast Pulses - A method for writing a Bragg grating in a rare-earth doped glass optical waveguide is provided. Ultrafast optical pulses are generated, preferably in the femtosecond range and having a writing wavelength in the range of 300 nm to 700 nm and an intensity sufficient to induce a change of refractive index in the rare-earth doped glass waveguide through densification. The optical pulses are diffracted using a phase mask, to generate an interference pattern having a pitch providing a fundamental Bragg resonance corresponding to the target wavelength to be reflected by the grating. The interference pattern is impinged on a region of the rare-earth doped glass waveguide, which is heated to a temperature above a threshold of about 350° C., for a predetermined heating period. Advantageously, the heating step allows the elimination of photodarkening effects which would otherwise be present in the waveguiding properties of the waveguide. | 05-24-2012 |
20120040368 | MUTATED VOLTAGE-GATED SODIUM CHANNEL NAV ALPHA SUBUNIT FOR IDENTIFICATION OF MODULATORS - Reagents, methods and kits for screening for compounds that modulate the activity of voltage-gated sodium channels (NaV), such as human NaV1.5/SC-N5A/hH1 are described. The reagents, methods and kits are based on mutated NaV alpha subunit polyptides of SEQ ID NO:5 with mutations at positions 372, 898, 1419 and 1711 (the DEKA motif) and at positions 11485, 1486 and 1487 (the IFM motif) resulting in increased permeability for a group IIA divalent cation (Ca | 02-16-2012 |
20120022049 | NICOTINIC RECEPTOR AGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES - Nicotine receptor agonists or analogs or derivatives thereof for treating inflammatory pulmonary diseases, and pharmaceutical compositions including nicotine receptor agonists or analogs or derivatives thereof. Compounds of formula wherein R1, R2, Xa and Ya are as defined herein are also provided. | 01-26-2012 |
20120020670 | METHOD AND SYSTEM FOR HIGH PRECISION GPS APPLICATIONS - A GPS system for obtaining data from a GPS signal received at a plurality of antenna stations, each antenna station being connected to a common receiver station through an optical fiber link The system includes a light generating module at the receiver station generating an optical reference signal, and an antenna station module at each antenna station. The antenna station modules modulate the optical reference signal according to the GPS signal received, obtaining a twice modulated optical signal, and sending this signal to the receiver station. Finally, an output module is provided at the receiver station, this module being used for extracting the GPS signal and the oscillating reference signal, calibrating in real time the optical fiber links based on a phase comparison, and processing the GPS signal from the antenna stations, taking into account the real time calibration of the optical fiber links. | 01-26-2012 |
20110312926 | 2-(N-Substituted Piperazinyl) Steroid Derivatives - Novel chemical agents are described herein. More specifically, 2-(N-substituted piperazinyl) pregnane and 2-(N-substituted piperazinyl) androstane derivatives exhibiting cytotoxicity on a variety of cancer cell lines are disclosed herein. | 12-22-2011 |
20110301152 | NICOTINIC RECEPTOR AGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES - Nicotine receptor agonists or analogs or derivatives thereof for treating inflammatory pulmonary diseases, and pharmaceutical compositions including nicotine receptor agonists or analogs or derivatives thereof. Compounds of formula wherein R1, R2, Xa and Ya are as defined herein are also provided. | 12-08-2011 |
20110294128 | Concentration and Enrichment of Microbial Cells and Microbial Nucleic Acids from Bodily Fluids - The present invention relates to a method for isolating microorganisms and/or microorganisms nucleic acids from a bodily fluid that may comprise or may be suspected to comprise microorganisms and/or host cells and/or host cells debris. Microorganisms nucleic acids may further be isolated by lysing the isolated microorganisms. The present invention also relates to a method for detecting microorganisms in a bodily fluid. The present invention further relates to a saponin formulation and its use. | 12-01-2011 |
20110256576 | RECOVERY AND DETECTION OF MICROORGANISMS FROM MIXED CELLULOSE ESTER FILTRATION SUPPORTS BY SEQUENTIAL TREATMENT WITH METHANOL AND ACETONE - The present invention is directed to the recovery of bacteria and microparasites, particularly | 10-20-2011 |
20110245270 | NICOTINIC RECEPTOR AGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES - Use of nicotine receptor agonists for treating inflammatory diseases, including a variety of pulmonary diseases. Such agonists have fewer side effects than other anti-inflammatory drugs, such as steroids. Moreover, these agonists can be used alone or in combination with other anti-inflammatory drugs to alleviate pulmonary diseases. For example, a method of treating pulmonary inflammation of an inflammatory disease selected from the group of asthma, interstitial pulmonary fibrosis (IPF), sarcoidosis, hypersensitivity pneumonitis (HP), and bronchiolitis obliterans with organizing pneumonitis (BOOP) in an animal in need thereof having said inflammation, including administering orally or by inhalation to said animal a nicotinic receptor agonist. | 10-06-2011 |
20110236394 | METHODS FOR THE REGULATION OF THE PROSTAGLANDIN F SYNTHASE (PGFS) ACTIVITY OF AKR1B1 AND USES THEREOF - AKR1B1 (EC 1.1.1.21) is an aldose reductase that has mainly been associated with the polyol pathway, and more recently with lipid deperoxidation. We have discovered that the primary activity of this enzyme is rather a PGFS activity, catalyzing the transformation of PGH | 09-29-2011 |
20110130862 | SENSOR FOR HANDLING SYSTEM - The cable lift system provides assistance to movement of a flexibly suspended payload actuated by operator input into one or more sensing devices attached to the payload. The sensing device is configured to collect information about the typical push-pull and lift-lower motions of an operator moving the payload horizontally and/or vertically, such that the operator's input to the sensor is intuitive and is provided in a manner which is substantially transparent to the operator. The assist mechanisms included in the system are actuated by a controller processing signals received from the one or more sensing devices on the payload. Movement assistance is provided such that the manual effort required by the operator to overcome the inertia of the payload in a starting or stopping event is substantially relieved, thus minimizing the ergonomic impact of the starting and stopping events on the operator. | 06-02-2011 |
20110127230 | ASSIST SYSTEM CONFIGURED FOR MOVING A MASS - An assist system is configured for moving a mass vertically, along a Z axis. The assist system includes a vertical actuation system, a cable, a plurality of pulleys, an actuator, and a mass. The pulleys are operatively attached to the support structure and an assist device that is movable attached to the support structure. The cable is routed around each of the pulleys and attached to the support structure. One of the pulleys supports the mass. The mass moves vertically in response to the actuator. | 06-02-2011 |
20110126660 | FORCE LIMITING DEVICE AND METHOD - The present invention relates to a method and apparatus for limiting the contact force between a moving device and another object, using a parallel mechanism and torque limiters where the threshold force to activate the force limiting mechanism is not related to the configuration of the moving device or the location of the contact force relative to the activation point of the force limiting mechanism, and where the mechanism may be configured for one, two or three degrees of freedom. A counterbalance mechanism is also provided to counteract gravity load when the force limiting mechanism is configured for three degrees of freedom and responsive to contact forces including a vertical element. In particular, the invention relates to a method and apparatus for limiting the contact force between a moving robotic device and a contactable object. | 06-02-2011 |
20110116020 | SURFACE PROGRAMMING METHOD AND LIGHT MODULATOR DEVICES MADE THEREOF - A liquid crystal display or other light modulator is provide with an alignment layer with a pretilt that is better than is currently available with rubbing technology. The liquid crystal cell consumes less electrical power to operate. The pretilt can be programmed using suitable field and recorded in the alignment layer. | 05-19-2011 |
20110109823 | METHOD AND APPARATUS FOR SPATIALLY MODULATED ELECTRIC FIELD GENERATION AND ELECTRO-OPTICAL TUNING USING LIQUID CRYSTALS - A variable optical device for controlling the propagation of light has a liquid crystal layer ( | 05-12-2011 |
20110104191 | MALVA MOSAIC VIRUS AND VIRUS-LIKE PARTICLES AND USES THEREOF - The immunogenic properties of the potexvirus MaI va mosaic virus (MaMV) and virus-like particles (VLPs) comprising the coat proteins of MaMV are disclosed VLPs prepared from MaMV coat proteins, methods of preparing the VLPs, MaMV coat protein polypeptides and polynucleotides encoding the coat protein are taught. Further, immunogenic compositions comprising MaMV or a VLP comprising the MaMV coat protein alone or in combination with one or more antigens and the use of said compositions to vaccinate and/or induce an immune response in an animal are also taught. | 05-05-2011 |
20100330586 | METHOD FOR IDENTIFYING COMPOUNDS FOR TREATMENT OF PAIN - Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride levels. The methods and products may also relate to modulation of the activity and/or expression of a chloride transporter, such as the KCC2 potassium-chloride cotransporter. Also described herein are commercial packages and uses based on such modulation. Related methods for identifying or characterizing a compound for the treatment of pain, the reduction of nociception and the diagnosis and prognostication of pain are also described. | 12-30-2010 |
20100279273 | NUCLEIC ACID SEQUENCES FOR THE AMPLIFICATION AND DETECTION OF RESPIRATORY VIRUSES - The present invention relates to methods of detection, as well as assays, reagents and kits for the specific detection of 15 clinically important respiratory viruses including influenza A and B viruses, human respiratory syncytial viruses, human metapneumoviruses, human enteroviruses, all serotypes of rhinoviruses, 7 serotypes of adenoviruses, parainfluenza viruses types 1, 2, 3, and 4, as well as coronaviruses NL, 229E, OC43, and SARS-CoV. The present invention allows for the detection of each of these respiratory viruses in a single assay. | 11-04-2010 |
20100277820 | MAGNETICALLY DEFORMABLE FERROFLUIDS AND MIRRORS - There is provided a process for the preparation of a suspension of magnetic particles in a polar carrier liquid. The process includes the step of: coating the surface of the magnetic particles with an organic ligand having a hydrophilic chain prior to the suspension. For preparing a magnetically deformable mirror, the suspension of magnetic particles in a polar carrier liquid is coated with a reflective surface layer. A ferrofluid includes a suspension of magnetic particles coated with an organic ligand having a hydrophilic chain in a polar carrier liquid. | 11-04-2010 |
20100227871 | NICOTINIC RECEPTOR AGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES - This invention relates to the use of nicotine receptor agonists for treating inflammatory diseases, including a variety of pulmonary diseases. Such agonists have fewer side effects than other anti-inflammatory drugs, such as steroids. Moreover, these agonists can be used alone or in combination with other anti-inflammatory drugs to alleviate pulmonary diseases. | 09-09-2010 |
20100227771 | METHODS FOR DETECTION OF TARGET ON RESPONSIVE POLYMERIC BIOCHIPS - Methods and tools (e.g., kits, articles of manufacturing, support and arrays) for the solid-phase detection of a target molecule using a cationic polymer and nucleic acid probe complex is provided herewith. These methods and tools allows for the reagentless, ultrasensitive and specific detection of nucleic acids, proteins and other molecules of interest and are based on a labeled complex made of specific capture probes and a polythiophene derivative. | 09-09-2010 |
20100217358 | ARTIFICIAL LIGHT APPARATUS AND ITS USE FOR INFLUENCING A CONDITION IN A SUBJECT - The present invention relates to an artificial light system for modulating circadian rhythms, increasing vigilance and influencing light-associated psychological conditions such as seasonal affective disorder. The system of the invention comprises a source of a green and/or red light and a source of blue light both light sources being controlled by a computer to provide predetermined light conditions. More specifically, the computer is programmed to provide pulses of blue light and continuous or pulsed red light, to enhance the efficacy of blue light, reduce blue-light hazard and avoid stroboscopic effect. | 08-26-2010 |
20100121037 | METHOD FOR SELECTIVE FRACTIONATION OF GROWTH FACTORS FROM DAIRY PRODUCTS - The invention relates to the general field of protein fractionation, and more particularly to the selective fractionation of growth factor from dairy products, such as milk, whey and colostrum. There is provided methods for the selective fractionation of TGF-β, lactoferrin and bovine serum albumin. | 05-13-2010 |
20100021898 | MAMMALIAN OOCYTE DEVELOPMENT COMPETENCY GRANULOSA MARKERS AND USES THEREOF - The present invention relates to the competence of oocytes for uterine implantation and development into living individuals. The invention more particularly relates to markers that are detected and measured in granulosa cells collected along with the oocytes during oocyte aspiration as it is done in assisted reproduction techniques. Markers include cytochrome P450 aromatase (CYP19A1), cell division cycle 42 (CDC42), 3-β-hydroxysteroid dehydrogenase 1 (3βHSD1), serpm peptidase inhibitor clade E member 2 (SERPINE 2), and adrenodoxm (ADX) that are detected and measured, using RT-PCR. | 01-28-2010 |
20100007844 | ELECTRICALLY VARIABLE FOCUS POLYMER-STABILIZED LIQUID CRYSTAL LENS HAVING NON-HOMOGENOUS POLYMERIZATION OF A NEMATIC LIQUID CRYSTAL/MONOMER MIXTURE - A variable focus liquid crystal lens includes a nematic liquid crystal/monomer mixture having a spatially inhomogenous polymer network structure, and an electrode for applying a substantially uniform voltage to the nematic liquid crystal/monomer mixture. The lens is created within a cell by applying a substantially uniform electric field to the nematic liquid crystal/monomer mixture within the cell, while simultaneously irradiating the nematic liquid crystal/monomer mixture using a laser beam having a shaped intensity distribution, so as to induce formation of a spatially inhomogenous polymer network structure within the cell. | 01-14-2010 |
20090315297 | TRAILER - Improved trailers (e.g., semi-trailers) are disclosed. The trailers may include a floor having a top surface and a bottom surface, where the top surface is adapted to transport a payload, and an elongated shell connected to the bottom surface of the floor, where the elongated shell defines a portion of a substantially closed torsion-resistant chamber of the trailer. The trailers may have a torsion resistance that is substantially higher than conventional trailers of similar size and/or load capacity. The trailers may weigh substantially less than conventional trailers of similar size and/or load capacity. The trailers may realize a bending resistance that is at least equivalent to the bending resistance of conventional trailers of similar size and/or load capacity. | 12-24-2009 |
20090297545 | IMMUNOMODULATORY DAIRY PEPTIDES AND USES THEREOF - The present invention provide a new method for modulating the immune system of a subject in need thereof by administering a dairy-derived peptide to the subject, particularly a β-lactoglubulin-derived peptide (β-Lg peptide). According to one aspect, the modulation of the immune system is the modulation of a Th1 response. According to another aspect, the modulation of the immune system is the modulation of a Th2 response. | 12-03-2009 |
20090274420 | System and Method for Permanently Writing a Diffraction Grating in a Low Phonon Energy Glass Medium - A system and method for permanently writing diffraction gratings in low phonon energy glass waveguides are shown. Ultrashort light pulses are generated and made to form two beams synchronously superimposed in the waveguide, therefore forming an interference pattern corresponding to the desired grating. The light pulses are focussed so that the light intensity in the waveguide exceeds a filamentation threshold. The exposure of the waveguide to these light pulses is controlled temporally and spatially in order to limit detrimental thermal effects induced by the high-intensity pulses in the glass medium of the waveguide. | 11-05-2009 |
20090246513 | Process for Producing Anti-Fog Coating - The invention relates to an anti-fog coating for a surface of a substrate comprising: a first polymer layer resulting from covalently bonding a polyanhydride polymer to said surface; and a second polymer layer resulting from covalently bonding a polymer selected from the group consisting of polyvinyl alcohol, partially hydrolyzed polyester, polyether and cellulose derivative; said surface having nucleophilic groups. A substrate having an anti-fog coating, as well as a process for preparing said anti-fog coating to the surface of a substrate is also provided. | 10-01-2009 |
20090236510 | SCINTILLATING FIBER DOSIMETER ARRAY - A radiation dosimetry apparatus and method use a scintillating optical fiber array for detecting dose levels. The scintillating optical fiber detectors generate optical energy in response to a predetermined type of radiation, and are coupled to collection optical fibers that transmit the optical energy to a photo-detector for conversion to an electrical signal. The detectors may be embedded in one or more modular, water-equivalent phantom slabs. A repeatable connector couples the collection fibers to the photo-detector, maintaining the fiber ends in a predetermined spatial relationship. The detector fibers may be distributed as desired in a three-dimensional detection space, and may be oriented with their longitudinal axes at different orientations relative to a transmission axis of an incident radiation beam. A calibration method uses two measurements in two spectral windows, one with irradiation of the scintillator at a known dose and one with only irradiation of the collection fiber. | 09-24-2009 |
20090107840 | METHODS, SYSTEMS AND APPARATUS FOR DETERMINING COMPOSITION OF FEED MATERIAL OF METAL ELECTROLYSIS CELLS - Systems and methods for determining compositions of cover materials for electrolysis cells are provided. In one embodiment a system includes an aluminum electrolysis cell adapted to contain an electrolytic bath, a hopper configured to provide a cover material to the aluminum electrolysis cell, where the cover material includes alumina and electrolytic bath particulate, an imaging device configured to capture images of the cover material, an image processor configured to analyze the images and output imaging data relating to the cover material, and a data analyzer configured to analyze the imaging data and output a determined cover material composition in the form of cover material information. The cover material information may be used to manage operation of the aluminum electrolysis cell, such as via adjusting the composition or feed rate of the cover material. | 04-30-2009 |
20090074278 | METHOD AND APPARATUS FOR METAL ARTIFACT REDUCTION IN COMPUTED TOMOGRAPHY - A method for reducing artifacts in an original computed tomography (CT) image of a subject, the original (CT) image being produced from original sinogram data. The method comprises detecting an artifact creating object in the original CT image; re-projecting the artifact creating object in the original sinogram data to produce modified sinogram data in which missing projection data is absent; interpolating replacement data for the missing projection data; replacing the missing projection data in the original sinogram data with the interpolated replacement data to produce final sinogram data; and reconstructing a final CT image using the final sinogram data to thereby obtain an artifact-reduced CT image. | 03-19-2009 |
20090017732 | METHOD AND APPARATUS FOR MICRO-MACHINING A SURFACE - An apparatus and method for micro-machining a surface of a workpiece having a complex surface profile including desired profile features and finer undesired profile features to be removed, including shaping a formable polishing tool using either the workpiece itself or a replica of the workpiece to have at least said desired profile features, and using said formable polishing tool to micro-machine said surface to remove said finer undesired profile features while maintaining said desired profile features. The formable polishing tool can be shaped to have at least said desired profile features by pressing the formable polishing tool against either the workpiece itself or the replica of the workpiece when the formable polishing tool is in a formable state, and the formable polishing tool can be used for micro-machining when the formable polishing tool is in a solid state. | 01-15-2009 |
20080225383 | Method and Devices for Generating Stable and Tunable Light Pulses - Methods and devices for generating stable, tunable and intense output light pulses are provided. A primary beam of light pulses is used to form a filament in an interaction zone. A secondary bean of light pulses is superposed with the filament and interacts therewith to generate the output light pulses. The parameters of the primary and secondary beams in the interaction zone can be controlled to obtain targeted optical characteristics of the output pulses. Multiple secondary beaus may also be used. | 09-18-2008 |
20080221085 | Nicotinic Receptor Agonists for the Treatment of Inflammatory Diseases - Nicotine receptor agonists or analogs or derivatives thereof for treating inflammatory pulmonary diseases, and pharmaceutical compositions including nicotine receptor agonists or analogs or derivatives thereof. Compounds of formula wherein R1, R2, Xa and Ya are as defined herein are also provided. | 09-11-2008 |