The Trustees of Columbia University in the City of Patent applications |
Patent application number | Title | Published |
20120324986 | SPECTRAL AND TEMPORAL LASER FLUORESCENCE ANALYSIS SUCH AS FOR NATURAL AQUATIC ENVIRONMENTS - An Advanced Laser Fluorometer (ALF) can combine spectrally and temporally resolved measurements of laser-stimulated emission (LSE) for characterization of dissolved and particulate matter, including fluorescence constituents, in liquids. Spectral deconvolution (SDC) analysis of LSE spectral measurements can accurately retrieve information about individual fluorescent bands, such as can be attributed to chlorophyll-a (Chl-a), phycobiliprotein (PBP) pigments, or chromophoric dissolved organic matter (CDOM), among others. Improved physiological assessments of photosynthesizing organisms can use SDC analysis and temporal LSE measurements to assess variable fluorescence corrected for SDC-retrieved background fluorescence. Fluorescence assessments of Chl-a concentration based on LSE spectral measurements can be improved using photo-physiological information from temporal measurements. Quantitative assessments of PBP pigments, CDOM, and other fluorescent constituents, as well as basic structural characterizations of photosynthesizing populations, can be performed using SDC analysis of LSE spectral measurements. | 12-27-2012 |
20120107562 | METHODS FOR GRAPHENE-ASSISTED FABRICATION OF MICRO-AND NANOSCALE STRUCTURES AND DEVICES FEATURING THE SAME - Methods for graphene-assisted fabrication of a surface on a substrate are disclosed herein. In an exemplary method, fabricating an etched surface on a substrate includes, depositing at least one layer of graphene on the surface on the substrate, patterning the deposited layer of graphene, and exposing the surface on a substrate to an acid to etch the surface on the substrate. The method can further include forming the layer of graphene from graphite. In some embodiments, the layer of graphene is formed by mechanically exfoliating the layer of graphene from the graphite. Alternatively, the layer of graphene can be formed by chemically exfoliating the graphene from the graphite, or other carbon materials, and/or utilizing vapor deposition to form the layer of graphene from the graphite, or other carbon materials. | 05-03-2012 |
20110172929 | SYSTEM AND METHOD FOR PREDICTION OF PHENOTYPICALLY RELEVANT GENES AND PERTURBATION TARGETS - Disclosed herein is a systems biology approach to prediction of phenotypically relevant genes such as oncogenes and perturbation targets. Interactions from a comprehensive cellular network such as the B Cell Interactome (BCI) can be used to identify those that become affected, or dysregulated, by a phenotype (e.g, disease, tumor and cancer) or perturbation (e.g., drug treatment) based on correlation changes between expression profiles of gene pairs in the interactions upon removal or addition of samples showing the phenotype or perturbation. Genes can be ranked based on the affected interactions involving the genes to predict phenotypically relevant genes and/or perturbation targets. | 07-14-2011 |
20110108108 | FLASH LIGHT ANNEALING FOR THIN FILMS - A method of making a crystalline film includes providing a film comprising seed grains of a selected crystallographic surface orientation on a substrate; irradiating the film using a pulsed light source to provide pulsed melting of the film under conditions that provide a mixed liquid/solid phase and allowing the mixed solid/liquid phase to solidify under conditions that provide a textured polycrystalline layer having the selected surface orientation. One or more irradiation treatments may be used. The film is suitable for use in solar cells. | 05-12-2011 |
20100296634 | Systems, Methods, and Media for Connecting Emergency Communications - Systems, methods, and media for connecting emergency communications are provided. For example, the methods can include: receiving an emergency communication at a particular public safety answering point from a caller directed to the particular public safety answering point by a location-to-service system; creating a conference on a conference system in response to the particular public safety answering point accepting the emergency communication; selecting a particular call-taker of a plurality of call-takers; sending the particular call-taker an invitation to accept the emergency communication; in response to receiving an indication that the particular call-taker has accepted the emergency communication, connecting the selected call-taker to the conference; connecting the caller to the conference; determining the location of the caller; querying the location-to-service system to identify at least one particular emergency responder of a plurality of emergency responders; and connecting at least one of the at least one particular emergency responder to the conference. | 11-25-2010 |
20100293407 | Systems, Methods, and Media for Recovering an Application from a Fault or Attack - Systems, methods, and media for recovering an application from a fault or an attack are disclosed herein. In some embodiments, a method is provided for enabling a software application to recover from a fault condition. The method includes specifying constrained data items and assigning a set of repair procedures to the constrained data items. The method further includes detecting a fault condition on the constrained data items during execution of the software application, which triggers at least one repair procedure. The triggered repair procedures are executed and the execution of the software application is restored. In some embodiments, the restoring comprises providing memory rollback to a point of execution of the software application before the fault condition was detected. | 11-18-2010 |
20100216889 | PROLONGED EFFECT DISINFECTANT CLEANSER - The present invention relates to cleanser compositions, and their uses, wherein the cleanser compositions comprise one or more cationic antiseptic agents, a film-forming cationic emulsifying agent, a dispersing auxiliary solvent, a solvent system, and optionally an alkanediol. | 08-26-2010 |
20100209352 | SYNTHESIS AND CONJUGATION OF IRON OXIDE NANOPARTICLES TO ANTIBODIES FOR TARGETING SPECIFIC CELLS USING FLUORESCENCE AND MR IMAGING TECHNIQUES - The invention provides for methods for producing water-soluble iron oxide nanoparticles comprising encapsulating the nanoparticles in phospholipids micelles. Also provided are methods for conjugating the inventive nanoparticles via functionalized phospholipids to a target molecule, such as an antibody. The invention further provides methods for using the nanoparticle-antibody conjugate of the invention as a contrast agent to image specific cells or proteins in a subject using fluorescent and magnetic imaging techniques. | 08-19-2010 |
20100158805 | QUANTUM DOT LABELED STEM CELLS FOR USE IN CARDIAC REPAIR - The present invention provides methods and compositions relating to the labeling of target cells with quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QDs for delivery of a tracking fluorescent signal into the cytosol of target cells via a passive endocytosis-mediated delivery process. In a specific embodiment of the invention the target cell is a stem cell, preferably a mesenchymal stem cell (MSC). Such labeled MSCs provide a means for tracking the distribution and fate of MSCs that have been administered to a subject to promote cardiac repair. The invention is based on the discovery that MSCs can be tracked in vitro for up to at least 6 weeks. Additionally, QDs delivered in vivo can be tracked for up to at least 8 weeks, thereby permitting for the first time, the complete 3-D reconstruction of the locations of all MSCs following administration into a host. | 06-24-2010 |
20100113598 | HIGH DOSE GLYCINE AS A TREATMENT FOR OBSESSIVE-COMPULSIVE DISORDER AND OBSESSIVE COMPULSIVE SPECTRUM DISORDERS - The present invention provides for a method of treating OCD or an Obsessive-Compulsive Spectrum Disorder (OCSD), such as BDD or ADHD, using a high-dose glycine treatment. | 05-06-2010 |
20100093684 | SYNERGISTIC INTERACTION OF NOTCH-1 INHIBITORS WITH GLUCOCORTICOIDS - The present invention relates to methods and compositions for preventing and/or treating various conditions in a patient, including for example, T-cell lymphoblastic leukemia and lymphoma as well as neurodegenerative diseases, such as for example, Alzheimer's disease. In one preferred embodiment of the invention, such methods include providing a patient with an effective amount of a combination of a NOTCH-1 inhibitor and glucocorticoid. The present invention further encompasses methods for increasing the efficacy of, and mitigating resistance to, glucocorticoids in the treatment of T-cell lymphoblastic leukemia and lymphoma, which generally include providing a patient with an effective amount of one or more NOTCH-1 inhibitors. | 04-15-2010 |
20090298072 | DNA Sequencing by Nanopore Using Modified Nucleotides - This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides. | 12-03-2009 |
20090222477 | METHODS, SYSTEMS, AND MEDIA FOR FORMING LINEAR COMBINATIONS OF DATA - Methods, systems, and media for forming linear combinations of data are provided. In some embodiments, methods for forming a linear combination of data include: receiving at a device a first codeword, wherein the first codeword comprises a linear combination of at least a first data unit including data, and a second data unit including data; encoding at the device the first codeword and a third data unit including data to form a second codeword, wherein the second codeword includes a linear combination of at least the first data unit, the second data unit, and the third data unit; and transmitting from the device the second codeword. | 09-03-2009 |
20090214465 | Quinoxaline Derivatives as Antitumor Agents - The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives. | 08-27-2009 |
20090105332 | PROCESSES OF MAKING SESQUITERPENOID TASHIRONIN, ITS ANALOGS AND THEIR USES - A compound having the structure of the formula (genus of compound 1 excluding Tashironin or Debenzoyltashironin) | 04-23-2009 |
20090060925 | Rage Fusion Proteins and Methods of Use - Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies. | 03-05-2009 |
20080280297 | Compositions and Methods for Differential Diagnosis of Chronic Lymphocytic Leukemia - The invention provides compositions and methods for determining a prognosis of a B cell chronic lymphocytic leukemia (CLL) in a subject based on the level of expression of at least one marker gene. Marker genes provided by the invention are SEPTlO, KIAA0799, Hs.23133, and ADAM29. The marker genes can be used to differentially diagnose CLL in a subject based on relative gene expression levels in the subject compared to reference gene expression levels established from a clinically characterized population of patients. The invention also provides diagnostic reagents and compositions and kits based on the marker genes. | 11-13-2008 |