THE OHIO STATE UNIVERSITY Patent applications |
Patent application number | Title | Published |
20160120895 | MicroRNAs useful for Treating Ovarian Cancer - Described herein are methods for diagnosing ovarian cancer. In particular, certain microRNAs are useful to the response to chemotherapy of ovarian cancer patients. | 05-05-2016 |
20160075883 | METHODS OF FABRICATING SUPERHYDROPHOBIC, OPTICALLY TRANSPARENT SURFACES - Methods and solutions for fabricating a superhydrophobic, optically transparent surface on a substrate. A dip coating technique is employed in which a solution comprising hydrophobic nanoparticles, a resin binder and a solvent is provided. The substrate is dipped and then withdrawn from the solution. As the substrate is withdrawn, a precursor coating of the solution is formed on a surface of the substrate. The solvent in the precursor coating is allowed to evaporate (is otherwise removed), immediately resulting in a superhydrophobic, optically transparent coating on the substrate surface. The hydrophobic nanoparticles can be metal oxide nanoparticles (such as SiO | 03-17-2016 |
20160046947 | Materials and Methods Useful For Affecting Tumor Cell Growth, Migration and Invasion - It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein. | 02-18-2016 |
20160017150 | METHOD OF ISOLATING BLUE ANTHOCYANIN FRACTIONS - The present invention is directed to a method of isolating fractions of anthocyanin molecules from anthocyanin-containing vegetable and fruit juices and extracts, or combinations thereof, at a select pH based on differences in polarity of the anthocyanin molecules in the anthocyanin-containing vegetable and fruit juices and extracts. | 01-21-2016 |
20160015067 | NATURAL BLUE ANTHOCYANIN-CONTAINING COLORANTS - The present invention is directed to natural blue anthocyanin-containing colorants comprising fractions of anthocyanin molecules separated from anthocyanin-containing vegetable and fruit juices and extracts. Anthocyanin fractions are separated at a select pH based on differences in polarity of the anthocyanin molecules in the anthocyanin-containing vegetable and fruit juices and extracts. The invention is directed to the anthocyanin fractions providing color characteristics similar to those provided by the synthetic blue colorant, FD&C Blue No. 1. The present invention is also directed to natural green colorants comprising the natural blue anthocyanin-containing colorant and a natural yellow colorant. The present invention is further directed to edible products comprising the natural blue anthocyanin-containing colorants. | 01-21-2016 |
20150329919 | USE OF MiR-26 FAMILY AS A PREDICTIVE MARKER FOR HEPATOCELLULAR CARCINOMA AND RESPONSIVENESS TO THERAPY - Provided is a method of selecting a patient diagnosed with HCC as a candidate for IFN-α therapy, by detecting the level of microRNA-26 expression in a sample obtained from the patient. | 11-19-2015 |
20150225721 | Methods and Compositions Using miR-3151 in the Diagnosis and Treatment of Cancer - Compositions comprising therapeutic oligonucleotide miR-3151 compounds that target the expression of genes associated with tumorigenesis or cell transformation are provided. | 08-13-2015 |
20150151973 | COVALENTLY-BONDED GRAPHENE COATING AND ITS APPLICATIONS THEREOF - A facile method to produce covalently bonded graphene coating on various solid substrates is disclosed in the present invention. According to one embodiment, a combination of graphite, graphene oxide or graphene and silicon compound with or without a metal containing compound in an air free environment is processed at high temperatures to produce covalent carbide bonding among graphene layers and between graphene and substrate surface. | 06-04-2015 |
20150126585 | Materials and Methods Related to MicroRNA-21, Mismatch Repair, and Colorectal Cancer - Described herein is the discovery that miR-21 targets and down-regulates the core mismatch repair (MMR) recognition protein complex hMSH2 and hMSH6. Anti-sense miR-21 is therefore proven as therapeutic herein. Therefore, compositions, kits, therapies and other methods, including methods of treatment/amelioration of symptoms, are disclosed herein. | 05-07-2015 |
20150104475 | COMPOSITIONS AND METHODS RELATED TO VIRAL VACCINES - Provided herein are methods and compositions relating to Infectious Bursal Disease Virus (IBDV), and vaccines for treatment and prevention thereof. | 04-16-2015 |
20150104412 | Materials and Methods Useful for Affecting Tumor Cell Growth, Migration and Invasion - It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein. | 04-16-2015 |
20150038443 | Transcription Factor Inhibitors and Related Compositions, Formulations and Methods - The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of research, diagnostic and therapeutic purposes. STAT3 inhibitors, particularly LLL12, are disclosed. The STAT3 inhibitors are useful to treat breast cancer in general and breast cancer initiating cells in particular. | 02-05-2015 |
20150025045 | CBP AND p300-MEDIATED TRANSCRIPTION MODULATORS AND RELATED METHODS - The present invention relates to gene regulation. In particular, the present invention provides small compounds capable of modulating p300 and/or CBP-mediated transcription and related methods of therapeutic and research use. In addition, the present invention provides methods for treating conditions associated with aberrant p300 and/or CBP-mediated transcription with p300 and/or CBP-mediated transcription modulators (e.g., p300 and/or CBP-mediated transcription inhibitors). | 01-22-2015 |
20150017156 | ESX-MEDIATED TRANSCRIPTION MODULATORS AND RELATED METHODS - The present invention relates to gene regulation. In particular, the present invention provides small compounds capable of modulating ESX-mediated transcription and related methods of therapeutic and research use. In addition, the present invention provides methods for treating conditions associated with aberrant EGFR expression with ESX-mediated transcription modulators (e.g., ESX-mediated transcription inhibitors). | 01-15-2015 |
20150010647 | Methods for Identifying Fragile Histidine Triad (FHIT) Interaction and Uses Thereof - Provided herein are methods and compositions for the diagnosis, prognosis and treatment of a cancer associated disorders using the Fhit gene. | 01-08-2015 |
20140378535 | Breast Cancer Biomarker Signatures for Invasiveness and Prognosis - MicroRNA profiles transition from normal breast to ductal carcinoma in situ and transition to invasive ductal carcinoma (IDC) and methods of use thereof are described. Methods of diagnosis and prognosis using microRNA signatures to differentiate invasive from in situ carcinoma are described. Also described is the use of microRNA expression for predicting overall survival and time to metastasis. | 12-25-2014 |
20140357697 | Materials and Methods Related to Modulation of Mismatch Repair and Genomic Stability by miR-155 - The present invention provides materials and methods related to modulation of mismatch repair and genomic stability by miR-155. | 12-04-2014 |
20140336488 | DEVICES AND METHODS FOR THE RAPID AND ACCURATE DIAGNOSIS AND TREATMENT OF SINUSITIS - Disclosed are probes, systems, and devices that can be used to assay the presence of a biomarker in the sinus of a patient. The probes, systems, and devices can be used to contact the sinus fluid inside the sinus of a patient with an immunoassay for the presence of a biomarker that is characteristic of sinusitis. The probes can therefore be used to determine the underlying cause of sinusitis in a patient. Also provided are methods of treating sinusitis by administering to a patient a therapeutic regimen selected in view of a biomarker detected in the sinus of the patient. As the biomarker is associated with one or more causative agents of sinusitis, a therapy effective to treat the underlying causative agent can be selected. | 11-13-2014 |
20140318657 | FLUID CONVEYING APPARATUS WITH LOW DRAG, ANTI-FOULING FLOW SURFACE AND METHODS OF MAKING SAME - A fluid conveying apparatus including a wall structure forming a channel for conveying fluid. The channel is bounded by an interior face of the wall structure. A rice leaf-like textured surface is formed on the interior face. The textured surface includes a plurality of micropillars projecting from the interior face and arranged in a geometry akin to rice leaf micropapillae. In some embodiments, the textured surface is a replica of a rice leaf hierarchical structure. In other embodiments, the micropillars are arranged to define a plurality of longitudinal grooves having a transverse sinusoidal pattern. The micropillars can are arranged in a substantially uniform micropattern, and have a diameter of about 2 μm, a height of about 4 μm, and a pitch distance of about 4 μm. A nanostructured coating can assist in rendering the micropillars superhydrophobic, and mimics the waxy nanobumps of a native rice leaf. | 10-30-2014 |
20140314876 | PROTEOMICS BASED DIAGNOSTIC DETECTION METHOD FOR CHRONIC SINUSITIS - The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract. | 10-23-2014 |
20140277108 | SURGICAL INSTRUMENT FOR GRASPING MULTIPLE LOCATIONS AND METHODS OF USE - According to various implementations, a surgical instrument is provided that has two graspers for remotely grasping an organ or tissue in two different locations. The surgeon can manipulate the organ or tissue using the instrument with one hand while using his or her other hand to perform a surgical procedure. Using one instrument also reduces the number of incisions required. This instrument is especially useful in laproscopic procedures and other minimally invasive surgeries. | 09-18-2014 |
20140270076 | Rodent Ionizing Radiation Treatment Device - The present application relates to rodent radiation device that enables simultaneous radiation treatment of a plurality of small animals such as mice with localized radiation therapy. The device can provide clinically-relevant homogeneous radiation dosing and scheduling to a plurality of small animals or other in vivo cancer models simultaneously. Specifically, the multi station/unit design of the device allows for rapid loading of anesthetized small animals into radiation shield chambers that absorbs over 95% of the delivered dose and protects the remainder of the untreated animal, allowing for more clinically accurate recapitulation of radiotherapy regimens. In one embodiment, a total of 40-50 Gy is delivered in 20-25 fractions to small animals with more than 95% survival rates. | 09-18-2014 |
20140256591 | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Ovarian Cancer Using a Real-Time PCR Platform - Methods and compositions for the diagnosis, prognosis and/or treatment of ovarian cancer are disclosed. | 09-11-2014 |
20140212015 | De-noising of Real-time Dynamic Magnetic Resonance Images by the Combined Application of Karhunen-Loeve Transform (KLT) and Wavelet Filtering - A hybrid filtering method called Karhunen Loeve Transform-Wavelet (KW) filtering is presented to de-noise dynamic cardiac magnetic resonance images that simultaneously takes advantage of the intrinsic spatial and temporal redundancies of real-time cardiac cine. This filtering technique combines a temporal Karhunen-Loeve transform (KLT) and spatial adaptive wavelet filtering. KW filtering has four steps. The first is applying the KLT along the temporal direction, generating a series of “eigenimages”. The second is applying Marcenko-Pastur (MP) law to identify and discard the noise-only eigenimages. The third applying a 2-D spatial wavelet filter with adaptive threshold to each eigenimage to define the wavelet filter strength for each of the eigenimages based on the noise variance and standard deviation of the signal. Lastly, the inverse KLT is applied to the filtered eigenimages to generate a new series of cine images with reduced image noise. | 07-31-2014 |
20140187609 | Mutator Activity Induced by microRNA-155 (miR-155) Links Inflammation and Cancer - Methods of reducing spontaneous mutation rate of a cell in a subject in need thereof by reducing endogenous levels of miR-155 are described. | 07-03-2014 |
20140173784 | AZALEA PLANT NAMED "STEWLA#1" - A new and distinct cultivar of Azalea plant named ‘Stewla#1’, characterized by its globe to broad columnar plant form; freely branching habit; terminal truss flower arrangement; pure white hose-in-hose flowers with some yellow-green flecking in the throat of the petals; green-yellow flower buds; and hardiness in USDA zone 6a. | 06-19-2014 |
20140154162 | SEPARATION OF CARBON DIOXIDE (CO2) FROM GAS MIXTURES BY CALCIUM BASED REACTION SEPARATION (CaRS-CO2) PROCESS - A reaction-based process developed for the selective removal of CO2 from a multicomponent gas mixture to provide a gaseous stream depleted in CO2 compared to the inlet CO2 concentration. The proposed process effects the separation of CO2 from a mixture of gases by its reaction with metal oxides. The Calcium based Reaction Separation for CO2 (CaRS—CO2) process consists of contacting CO2 laden gas with CaO in a reactor such that CaO captures CO2 by the formation of CaCO3. CaCO3 is regenerated by calcination leading to the formation of fresh CaO sorbent and the evolution of a concentrated stream of CO2. The “regenerated” CaO is then recycled for the further capture of CO2. This carbonation-calcination cycle forms the basis of the CaRS—CO2 process. This process also may use a mesoporous CaCO3 structure that attains >90% conversion over multiple carbonation and calcination cycles. | 06-05-2014 |
20140148622 | Engineering Plants to Produce Farnesene and Other Terpenoids - The present invention relates to engineering plants to express higher levels than endogenous amounts of terpenoids, such as farnesene. Plants that can be so engineered include those with large carbon stores, such as sweet | 05-29-2014 |
20140147244 | LIQUID RING HEAT ENGINE - A method and at least two devices demonstrate improvements to energy extraction from a compressible rotation working fluid in a liquid ring heat engine, which has a rotor mounted in a case. A space in the case is occupied by a liquid that establishes a liquid ring piston for the rotor. The rotor defines at least a first and a second operating zone. In the first zone, the working fluid is expanded against the liquid and, in the second zone, the working fluid is re-compressed. Between the two zones, the working fluid is cooled. In one device, the cooling step occurs on the rotor in a third zone. In another device, the cooling occurs outside of the case. | 05-29-2014 |
20140144082 | Methods of Converting Fuel - A method for converting fuel may include reducing at least one metal oxide in a first reactor with a fuel to produce a reduced metal or a reduced metal oxide, transporting the reduced metal or reduced metal oxide from the first reactor to a second reactor, oxidizing at least a portion of the reduced metal or reduced metal oxide from the first reactor in the second reactor to produce a metal oxide intermediate, transporting the metal oxide intermediate from the second reactor to a third reactor, removing ash, char, or unwanted materials with a separation unit from the metal oxide intermediate transported from the second reactor to the third reactor, regenerating the at least one metal oxide, and transporting the regenerated metal oxide from the third reactor to the first reactor. | 05-29-2014 |
20140127254 | TRANSGENIC ALGAE FOR DELIVERING ANTIGENS TO AN ANIMAL - Delivery systems and methods are provided for delivering a biologically active protein to a host animal. The systems and methods provided include obtaining an algal cell transformed by an expression vector, the expression vector comprising a nucleotide sequence coding for the biologically active protein, operably linked to a promoter. In one illustrated embodiment, the biologically active protein is an antigenic epitope and upon administration to the animal the algal cell induces an immune response in the host animal. | 05-08-2014 |
20140113600 | PREDICTIVE NETWORK SYSTEM AND METHOD - A proactive networking system and method is disclosed. The network anticipates the user demands in advance and utilizes this predictive ability to reduce the peak to average ratio of the wireless traffic and yield significant savings in the required resources to guarantee certain Quality of Service (QoS) metrics. The system and method focuses on the existing cellular architecture and involves the design and analysis of learning algorithms, predictive resource allocation strategies, and incentive techniques to maximize the efficiency of proactive cellular networks. The system and method further involve proactive peer-to-peer (P2P) overlaying, which leverages the spatial and social structure of the network. Machine learning techniques are applied to find the optimal tradeoff between predictions that result in content being retrieved that the user ultimately never requests, and requests that are not anticipated in a timely manner. | 04-24-2014 |
20140100133 | Methods for Diagnosing Breast Cancer Using MicroRNAs - Described herein are methods for diagnosing breast cancer using microRNAs. Also described are methods and compositions for the diagnosis and treatment of solid cancers. Methods of identifying inhibitors of tumorigenesis are also provided. | 04-10-2014 |
20140056949 | Controlled Release Mucoadhesive Systems - Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described. | 02-27-2014 |
20140056917 | FTY720 Increases CD74 Expression and Sensitizes Cancer Cells to Anti-CD74 Antibody-Mediated Cell Death - Disclosed herein are methods and compositions comprising fingolimod and anti-CD74 antibodies or fragments thereof. In preferred embodiments, the fingolimod increases the expression of CD74 in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 antibodies. The compositions and methods are of use to treat diseases involving CD74 | 02-27-2014 |
20140053296 | Highly Active Soybean Promoters and Uses Thereof - Soybean ubiquitin promoters and processes for expressing nucleic acids in transgenic plants under the control of a soybean ubiquitin promoter are described. | 02-20-2014 |
20140045918 | Materials and Methods Related to MicroRNA-21, Mismatch Repair, and Colorectal Cancer - The present invention discloses the discovery that miR-21 targets and down-regulates the core mismatch repair (MMR) recognition protein complex hMSH2 and hMSH6. Anti-sense miR-21 is therefore proven as therapeutic herein. Therefore, compositions, kits, therapies and other methods, including methods of treatment/amelioration of symptoms, are disclosed in the present invention. | 02-13-2014 |
20140044668 | Methods for Predicting Cardiovascular Risks and Responsiveness to Statin Therapy Using SNPs - Methods and compositions for the effect of Cholesteryl ester transfer protein (CETP) polymorphisms on mRNA splicing, statin treatment outcome, response to CETP inhibitor drugs, and myocardial infarction risk are described. | 02-13-2014 |
20140034134 | CIRCULATING FLUIDIZED BED WITH MOVING BED DOWNCOMERS AND GAS SEALING BETWEEN REACTORS - A system and process for carrying out one or more chemical reactions are provided and include one or more chemical reactors having particulate solids forming a bed therein, and a gas stripping zone forming a non-mechanical seal between said reactors which includes a conduit connecting the reactors. The conduit includes an inlet for a stripping gas which is adapted to prevent process gas from passing between reactors while permitting particulate solids to pass between reactors. | 02-06-2014 |
20140031291 | PP2A REGULATORY SUBUNIT MODIFICATION IN DISEASE - Disclosed herein are methods for the diagnosis, detection, and treatment of cardiovascular disease and symptoms thereof in a subject. Disclosed herein are methods of diagnosing ischemic heart disease, non-ischemic heart disease, myocardial infarction, tachy-pacing induced non-ischemic heart disease, heart failure, and catecholaminergic-induced arrhythmia and symptoms thereof in a subject. Disclosed herein are methods of screening the efficacy of a pharmaceutical agent for treating cardiovascular disease and symptoms thereof in a subject. Disclosed herein are methods of identifying a subject eligible for a cardiovascular disease treatment clinical trial | 01-30-2014 |
20140024624 | Method of Ameliorating Clotting Pathologies and Related Materials and Methods - Methods for reducing blood clotting in a subject are provided, including methods to reduce the risk of and/or treat blot clotting pathologies. Also provided are compositions useful to reduce the risk or treat blood clotting pathologies. | 01-23-2014 |
20140018412 | Methods for Diagnosing Lung Cancer using MicroRNAs - Described herein are methods for diagnosing lung cancer using microRNAs. Also described are methods and compositions for the diagnosis and treatment of solid cancers. Methods of identifying inhibitors of tumorigenesis are also provided. | 01-16-2014 |
20140018411 | Methods for Diagnosing Prostate Cancer using MicroRNAs - Described herein are methods for diagnosing prostate cancer using microRNAs. Also described are methods and compositions for the diagnosis and treatment of solid cancers. Methods of identifying inhibitors of tumorigenesis are also provided. | 01-16-2014 |
20140016575 | SYSTEM AND METHOD FOR PROACTIVE RESOURCE ALLOCATION - A system and method for allocating resources in a network is disclosed. The system and method comprises a proactive resource allocation framework in which the predictability of user behavior is exploited to balance the network traffic over time and to reduce the bandwidth required to achieve a given blocking/outage probability. The disclosed proactive resource allocation framework avoids limitations associated with off-peak demand and achieves a significant reduction in the peak to average demand ratio without relying on out of network users. It is based on a model in which smart devices are assumed to predict the arrival of new requests and submit them to the network T time slots in advance. Using tools from large deviation theory, the resulting prediction diversity gain is quantified to establish that the decay rate of the outage event probabilities increases linearly with the prediction duration T. | 01-16-2014 |
20140005250 | Compositions and Methods for Increasing Drug Efficacy in Cancer | 01-02-2014 |
20140003696 | AUTOMATED TRAJECTORY PLANNING FOR STEREOTACTIC PROCEDURES | 01-02-2014 |
20130336961 | B Cell Depletion for Central Nervous System Injuries and Methods and Uses Thereof - Therapeutic B lymphocyte (B cell) depleting antibodies and methods and uses thereof in the treatment of patients having central nervous system injuries are described. | 12-19-2013 |
20130331439 | Methods for Diagnosing Stomach Cancer Using MicroRNAs - Described herein are methods for diagnosing stomach cancer using microRNAs. Also described are methods and compositions for the diagnosis and treatment of solid cancers. Methods of identifying inhibitors of tumorigenesis are also provided. | 12-12-2013 |
20130324589 | Methods for Diagnosing Pancreatic Cancer Using MicroRNAs - Described herein are methods for diagnosing pancreatic cancer using microRNAs. Also described are methods and compositions for the diagnosis and treatment of solid cancers. Methods of identifying inhibitors of tumorigenesis are also provided. | 12-05-2013 |
20130323809 | METABOLIC ENGINEERING OF CLOSTRIDIUM TYROBUTYRICUM FOR BUTANOL PRODUCTION - This invention relates to compositions, systems, and methods for producing biofuels, such as butanol, and related compounds. More specifically, provided are methods of making recombinant microorganisms having non-naturally occurring metabolic pathways for the production of biofuels, and methods of producing biofuels using such organisms. Also provided are metabolically engineered microorganisms capable of producing butanol from a substrate. | 12-05-2013 |
20130315937 | LIPID NANOPARTICLE COMPOSITIONS FOR ANTISENSE OLIGONUCLEOTIDES DELIVERY - Described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a targeting agent. The composition can include a therapeutic agent. The therapeutic agent can be an antisense oligonucleotide (ASO). Exemplary ASOs are targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1; or targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Also described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a therapeutic agent that is an ASO such as an ASO targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1 or an ASO targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Pharmaceutical formulations, methods of making the lipid nanoparticles, and methods of using the lipid nanoparticles, for example for treating cancers, are also disclosed. | 11-28-2013 |
20130315796 | BIOLOGICAL CELL SEPARATOR AND DISPOSABLE KIT - A disposable kit for use in directing fluid through a biological cell separator device ( | 11-28-2013 |
20130309202 | Methods for Improving Liver Function - The present invention provides methods to improve liver function utilizing tocotrienols. In particular, various liver pathologies may be treated using the present methods, including cirrhosis, hepatitis, and sclerosing cholangtitis. The present invention also provides methods to increase tissue concentrations of tocotrienols. | 11-21-2013 |
20130302382 | Exercise Performance-Increasing Nutritional Supplement and Related Methods and Compositions - The present invention provides a nutritional supplement, comprising L-carnitine and phosphatidylserine; and optionally, further comprises at least one mineral selected from the group consisting of: iron; copper and zinc; and optionally, further comprises ferrous glycinate, copper glycinate and zinc glycinate. | 11-14-2013 |
20130289521 | SYSTEM AND METHOD FOR REGULATING ENDOGENOUS NEUROMODULATORY AGENT LEVELS - One aspect of the present disclosure includes a closed-loop therapy delivery system for regulating an endogenous level of a first neuromodulatory agent in a subject. The therapy delivery system includes a sensing component, a delivery component, and a controller. The sensing component is configured to detect an extracellular level of the first neuromodulatory agent. The delivery component is configured to deliver an amount of a second neuromodulatory agent to an intraparenchymal target site of the subject. The controller is configured to coordinate operation of the sensing component and the delivery component. | 10-31-2013 |
20130279781 | METHOD FOR ESTIMATING A GRAPPA RECONSTRUCTION KERNEL - A method for improving the signal-to-noise ratio (SNR) of TGRAPPA. The SNR of the ACS lines is proportional to the condition number of the GRAPPA kernel encoding equations. Therefore, the GRAPPA kernel estimated from higher SNR ACS lines amplifies the random noise in GRAPPA reconstruction. In TGRAPPA reconstruction of dynamic image series, a widely used method to acquire ACS lines is to average-all-frame (AAF). The present disclosure utilizes a tile-all-frame (TAF) as ACS lines to improve the SNR of the reconstructed images. | 10-24-2013 |
20130278256 | SELF-CONSTRAINT NON-ITERATIVE GRAPPA RECONSTRUCTION WITH CLOSED-FORM SOLUTION - Parallel magnetic resonance imaging (pMRI) reconstruction techniques are commonly used to reduce scan time by undersampling the k-space data. In GRAPPA, a k-space based pMRI technique, the missing k-space data are estimated by solving a set of linear equations; however, this set of equations does not take advantage of the correlations within the missing k-space data. All k-space data in a neighborhood acquired from a phased-array coil are correlated. The correlation can be estimated easily as a self-constraint condition, and formulated as an extra set of linear equations to improve the performance of GRAPPA. We propose a modified k-space based pMRI technique call self-constraint GRAPPA (SC-GRAPPA) which combines the linear equations of GRAPPA with these extra equations to solve for the missing k-space data. Since SC-GRAPPA utilizes a least-squares solution of the linear equations, it has a closed-form solution that does not require an iterative solver. | 10-24-2013 |
20130274824 | NEUROMODULATORY METHOD FOR TREATING CHRONIC RHINOSINUSITIS - One aspect of the present invention includes a method for treating chronic rhinosinusitis (CRS) in a subject. One step of the method includes implanting a therapy delivery system in the subject so that at least one therapy delivery component of the system is positioned substantially adjacent a target location where modulation of the autonomic nervous system (ANS) is effective to treat CRS. The therapy delivery component includes at least one electrode configured to deliver electric current to the target location. Next, electric current is delivered to the at least one electrode to effect a change in the ANS. | 10-17-2013 |
20130272963 | Cholesterol Efflux Assay Probe Formulations, Methods of Making and Using - A cholesterol efflux assay probe formulation having a core comprised of a biocompatible hydrophobic material at least partially coated with a sphingomyelin/cholesterol layer, methods of making and methods of using are described. | 10-17-2013 |
20130236453 | Methods and Compositions for Modulating Acute Graft-versus-Host Disease using miR-155 Specific Inhibitors - Methods and compositions for treating or preventing acute graft-versus-host disease (aGVHD) in a subject using miR-155 specific inhibitors are described. | 09-12-2013 |
20130231551 | SYSTEM AND METHOD FOR CARDIOVASCULAR EXERCISE STRESS MRI - A system and method for cardiovascular exercise stress magnetic resonance using a MR-compatible treadmill. The treadmill is made of non-ferromagnetic materials and has a belt driven by a motor that produces rotational motion from pressurized fluid that is produced by a pump located outside the scan room. The treadmill is adjacent to the MR imager. Patients complete an exercise protocol on the treadmill and are then transferred to the MR imager without leaving the scan room. Images are acquired as quickly as possible post-exercise to more accurately diagnose cardiovascular disease in patients. | 09-05-2013 |
20130229274 | THEFT DETECTION SYSTEMS AND METHODS - One aspect of the invention provides a theft detection system including one or more tag nodes configured to detect movement and transmit a beacon message and one or more anchor nodes configured to receive the beacon message from the one or more tag nodes and alert a third party of the beacon message. Another aspect of the invention provides a theft detection node including a power source, a motion detector, a transmitter, and a microcontroller in communication with the power source, the motion detector, and the transmitter. The microcontroller is configured to determine whether the node is being transported and if the node is being transported, instructing the transmitter to transmit a beacon message. Another aspect of the invention provides a theft detection method including detecting motion in a motor vehicle and transmitting a beacon message to an anchor node. | 09-05-2013 |
20130219995 | OBTAINING SELECTIVITY IN GAS SENSORS VIA A SENSOR ARRAY SYSTEM COMPOSED OF P AND N TYPE MATERIAL - Systems and methods for discriminating among volatile compounds is provided using a semiconductor junction structure or sensor device. Sensor devices of the present disclosure employ a combination of hole carriers (p-type) and electron carriers (n-type) metal oxides deposited, for example, on a gold microspring array designed so that it has several leads that are at different distances from each other. | 08-29-2013 |
20130219988 | NO SENSOR AND SENSOR SYSTEMS - Some aspects of the present disclosure relate to a sensor design that exploits the different majority carriers (holes/electrons) in WO | 08-29-2013 |
20130210667 | Biomarkers for Predicting Kidney and Glomerular Pathologies - Biomarkers for determining a kidney and glomerular pathologies and methods of using the same are described. | 08-15-2013 |
20130207075 | NANOSCALE EMITTERS WITH POLARIZATION GRADING - A nanowire comprises a polar semiconductor material that is compositionally graded along the nanowire from a first end to a second end to define a polarization doping profile along the nanowire from the first end to the second end. The polar semiconductor material may comprise a group IH-nitride semiconductor, such as an alloy of GaN and AlN, or an alloy of GaN and InN. Such nanowires may be formed by nucleating the first ends on a substrate, growing the nanowires by depositing polar semiconductor material on the nucleated first ends on a selected growth face, and compositionally grading the nanowires during growth to impart the polarization doping. The direction of the compositional grading may be reversed during the growing of the nanowires to reverse the type of the imparted polarization doping. In some embodiments, the reversing forms n/p or p/n junctions in the nanowires. | 08-15-2013 |
20130206183 | BRUSH WITH STRUCTURE FOR HAIR REMOVAL - A hair brush that permits quick and easy removal of hair has a handle attached to a head. The head is made up of at least two frames that are mounted to the handle through cantilevers that permit movement of the frames relative to one another. The bristles are mounted to the frames, preferably in single rows. A force applied to one frame moves that frame relative to the other frame and the handle, thereby permitting the user to reach between the frames to remove any hair that is caught in the bristles. The brush allows a gap between the bristles to be enlarged, thereby making removal using human fingers much easier. Repeated movement and return of the frames to their resting position can cause the hair fibers to work away from the bristle bases and make removal much easier. | 08-15-2013 |
20130204107 | DEVICES AND METHODS FOR THE RAPID AND ACCURATE DETECTION OF ANALYTES - Disclosed are field effect transistor-based (FET-based) sensors for the rapid and accurate detection of analytes both in vivo and in vitro. The FET-based sensors can include a substrate, a channel disposed on the substrate, a source electrode and a drain electrode electrically connected to the channel, and a recognition element for an analyte of interest immobilized on the surface of the channel via a linking group. The distance between the recognition element and the channel can be configured such that association of the analyte of interest with the recognition element induces a change in the electrical properties of the channel. In this way, an analyte of interest can be detected by measuring a change in an electrical property of the channel. Also provided are devices, including probes and multi-well plates, incorporating the FET-based sensors. | 08-08-2013 |
20130202111 | WIRELESS SECURITY PROTOCOL - A method of encryption and decryption applied to a transmitted plaintext message in a communication network containing multiple subscriber nodes is provided. The method comprises the steps of: processing an Integrity check value (ICV); using a private key at the first subscriber node; providing a random initialization vector (W) executing a first operation on the random IV to obtain a sum IV; using the sum IV to process an encryption on the plaintext to obtain the ciphertext; transmitting the ciphertext to the second subscriber node wherein the second node receives the ciphertext; identifies the IV; utilizes the private key and the IV to process the decryption of the ciphertext to obtain the plaintext; generates a feedback message, the feedback message is then used to generate future sum IVs. | 08-08-2013 |
20130201450 | DETECTION AND MEASUREMENT OF TISSUE IMAGES - A system and method of measuring a tissue structure is provided. The method includes obtaining image data of the tissue structure. Also, an anatomical landmark in the image data is identified. A first geometric shape is applied to the image data of the tissue structure based on the anatomical landmark. For example, the geometric shape may have a linear portion, such as a square or diamond. The method also includes applying a second geometric shape to the image data of the tissue structure based on the anatomical landmark. The second geometric shape may be different than the first geometric shape, such as an arc or parabola. The method also includes segmenting a first substructure of the image data from a second substructure of the image data. These substructures may be, for example, a sclera and ciliary body of an eye. | 08-08-2013 |
20130190386 | Breast Cancer Biomarker Signatures for Invasiveness and Prognosis - MicroRNA profiles transition from normal breast to ductal carcinoma in situ and transition to invasive ductal carcinoma (IDC) and methods of use thereof are described. Methods of diagnosis and prognosis using microRNA signatures to differentiate invasive from in situ carcinoma are described. Also described is the use of microRNA expression for predicting overall survival and time to metastasis. | 07-25-2013 |
20130190187 | FAST-CYCLING, CONDUCTION-COOLED, QUASI-ISOTHERMAL, SUPERCONDUCTING FAULT CURRENT LIMITER - Fault Current Limiters (FCL) provide protection for upstream and/or downstream devices in electric power grids. Conventional FCL require the use of expensive conductors and liquid or gas cryogen handling. Disclosed embodiments describe FCL systems and devices that use lower cost superconductors, require no liquid cryogen, and are fast cycling. These improved FCL can sustain many sequential faults and require less time to clear faults while avoiding the use of liquid cryogen. Disclosed embodiments describe a FCL with a superconductor and cladding cooled to cryogenic temperatures; these are connected in parallel with a second resistor across two nodes in a circuit. According to disclosed embodiments, the resistance of the superconducting components and its sheath in the fault mode are sufficiently high to minimize energy deposition within the cryogenic system, minimizing recovery time. A scheme for intermediate heat storage also is described which allows a useful compromise between conductor length enabled energy minimization and allowable number of sequential faults to enable an overall system design which is affordable, and yet allows conduction cooled (cryogen free) systems which have fast recovery and allows for multiple sequential faults. | 07-25-2013 |
20130188400 | ENHANCED FLYBACK CONVERTER - A DC/DC flyback converter that exhibits reduced switch and transformer voltage stresses in comparison to known flyback converters. The flyback converter also employs soft switching. Embodiments of such flyback converters may be used, without limitation, in electric vehicles and hybrid electric vehicles. A front-stage of the flyback converter comprises a DC/AC step-down circuit that may be separately used for various purposes. | 07-25-2013 |
20130165502 | Diagnostic, Prognostic and Therapeutic Uses of miRs in Adaptive Pathways and Disease Pathways - Described herein are methods and compositions for the diagnosis, prognosis and treatment of various adaptive and/or disease pathways by examining samples containing one or more miRs therein, and by formulating therapeutic agents therefrom. | 06-27-2013 |
20130162788 | Artificial Compound Eye With Adaptive Microlenses - An artificial compound eye formed of three layers of membrane bonded to one another in a stacked relationship. A field chamber is located intermediate the two bottommost membranes. A plurality of focus chambers is located intermediate the two topmost membranes, and an image sensor is located below each focus chamber. The field chamber and each focus chamber contain a pressurized fluid medium. The ceilings of the focus chambers function as lenses though which light must pass to reach the sensors. The fluid pressure in the field chamber can be varied to expand or contract the eye between a planer and a domed configuration, thereby allowing the field of view of the eye to be varied. The fluid pressure in each focus chamber can be varied to expand or contract each lens between a planar and a domed configuration for independently varying the focal length of each lens. | 06-27-2013 |
20130158378 | IONIC BARRIER FOR FLOATING GATE IN VIVO BIOSENSORS - An ion-sensitive sensor includes a dielectric layer comprising Al | 06-20-2013 |
20130153770 | Rapid Diagnosis of A Disease Condition Using Infrared Spectroscopy - Reliable and rapid diagnostic methods for many functional syndromes (FS) such as Bladder Pain Syndrome/Interstitial Cystitis (IC) are not available. Exemplary embodiments include rapid and accurate methods for diagnosing FS in humans and other mammals using infrared microspectroscopy (IRMS). Exemplary methods utilize Soft Independent Modeling by Class Analogy (SIMCA) to create classification models. Exemplary methods utilize classification models to categorize a subject's condition (e.g., healthy/sick and or flare/remission). Using these classification models, various embodiments enable diagnosis based on spectra data from a blood sample or other biomedical specimen. Exemplary embodiments may be useful for rapid diagnosis of IC and various other conditions in humans, cats, and/or other mammals. | 06-20-2013 |
20130150430 | Methods for Impairing the P53/HDM2 Auto-Regulatory Loop in Multiple Myeloma Development Using mIR-192, mIR-194 and mIR-215 - Methods and compositions for detecting, treating, characterizing, and diagnosing multiple myeloma are described. | 06-13-2013 |
20130143969 | CURCUMIN COMPOSITIONS AND USES THEREOF - A composition and method of increasing the bioavailability of curcumin is provided. A synergistic combination of excipient polymers provides increased bioavailability thereby increasing the plasma concentration of curcumin and its metabolite curcumin O-glucuronide. The curcumin pharmaceutical compositions are suitable for modifying DNA methylation and treating diseases such as cancer. | 06-06-2013 |
20130142729 | Anti-CD74 Immunoconjugates and Methods of Use - Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions. | 06-06-2013 |
20130139273 | Chronic Lymphocytic Leukemia Modeled in Mouse by Targeted miR-29 Expression - A mouse model and uses there of for detecting, treating, characterizing, and diagnosing various diseases are described. | 05-30-2013 |
20130137596 | MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic cancer agent. | 05-30-2013 |
20130123345 | METHOD OF TREATING A VIRAL INFECTION DYSFUNCTION BY DISRUPTING AN ADENOSINE RECEPTOR PATHWAY - Described herein is a method of treating a viral infection such as an influenza infection, in a subject comprising administering an effective amount of a pharmaceutical composition to disrupt a adenosine receptor pathway, such as the Aradenosine receptor pathway, in a subject. The adenosine receptor pathway includes the steps of 1) producing the adenosine precursor adenosine triphosphate (ATP), 2) releasing ATP into the extracel lular space, 3) enzymatic conversion of ATP to adenosine, 4) activation of the adenosine receptor and the adenosine receptor cascade, and 5) clearance of adenosine from the extracellular space by degradation or uptake into a cell. The method includes affecting at least one of these steps so as to decrease the activation of the adenosine receptor pathway. This may be accomplished by decreasing the production, release, or conversion of ATP to adenosine, decreasing the expression of the adenosine receptor, antagonizing adenosine receptor activation, and/or increasing adenosine clearance. | 05-16-2013 |
20130123343 | Methods for Reverting Methylation by Targeting Methyltransferase and Compositions Useful Therefor - Methods for restoring a desired pattern of DNA methylation, inducing re-expression of methylation-silenced tumor suppressor genes (TSGs), and/or inhibiting tumorigenicity both in vitro and in vivo in a subject in need thereof by administering an effective amount of one or more miR-29s sufficient to target one or more of DNMT3A and DNMT3B are disclosed. | 05-16-2013 |
20130096406 | System for In Vivo Biosensing Based on the Optical Response of Electronic Polymers - A system for continuous in vivo biosensing of specific analyte molecule concentrations based on the dynamic optical properties of electronic polymers is disclosed. The biosensor system includes at least one implant member subcutaneously exposed to the interstitial fluid of the subject, and a reader member at least temporarily positioned over the implant member to probe it with light of specific wavelengths through the skin. The system has many potential applications, including the real-time monitoring of blood glucose levels in diabetics as a method to supplement or replace conventional capillary blood testing. | 04-18-2013 |
20130096023 | Hepcidins as Biomarkers for Impending Lupus Nephritis Flare - Biomarkers for determining a kidney flare episode in systemic lupus erythematosus are described. | 04-18-2013 |
20130096022 | Methods and Materials Related to Ovarian Cancer - Described herein are methods for diagnosing ovarian cancer. In particular, certain microRNAs are useful to the response to chemotherapy of ovarian cancer patients. | 04-18-2013 |
20130085365 | ADAPTIVE ELECTRICAL CAPACITANCE VOLUME TOMOGRAPHY - An electrical capacitance tomography sensor comprised of a sensor having a plurality of electrodes, where each electrode is further comprised of a plurality of capacitance segments. Each of the capacitance segments of each electrode can be individually addressed to focus the electric field intensity or sensitivity to desired regions of the electrodes and the sensor. | 04-04-2013 |
20130078159 | SEPARATION OF CARBON DIOXIDE (CO2) FROM GAS MIXTURES BY CALCIUM BASED REACTION SEPARATION (CaRS-CO2) PROCESS - A reaction-based process developed for the selective removal of CO2 from a multicomponent gas mixture to provide a gaseous stream depleted in CO2 compared to the inlet CO2 concentration. The proposed process effects the separation of CO2 from a mixture of gases by its reaction with metal oxides. The Calcium based Reaction Separation for CO2 (CaRS-CO2) process consists of contacting CO2 laden gas with CaO in a reactor such that CaO captures CO2 by the formation of CaCO3. CaCO3 is regenerated by calcination leading to the formation of fresh CaO sorbent and the evolution of a concentrated stream of CO2. The “regenerated” CaO is then recycled for the further capture of CO2. This carbonation-calcination cycle forms the basis of the CaRS-CO2 process. This process also may use a mesoporous CaCO3 structure that attains >90% conversion over multiple carbonation and calcination cycles. | 03-28-2013 |
20130065946 | Materials and Methods Related to Modulation of Mismatch Repair and Genomic Stability by miR-155 - The present invention provides materials and methods related to modulation of mismatch and genomic stability by miR-155. | 03-14-2013 |
20130062332 | Ohmic Heating Packet - A hermetically-sealed, ohmic heating packet for storing, heating and sterilizing food and beverage items. The packet is formed of a multilayer laminate material having interior and exterior polymer layers and an intermediate metallic foil layer. Conductive tags on the exterior of the packet are electrically connected to electrodes on the interior of the packet through reverse-patched regions of the packet's sidewalls. The configuration of the electrical connection prevents current from leaking into the metallic foil layer of the packet during heating, thereby mitigating the risk of a short circuit condition in the packet. The rectangular prism geometry of the packet and the parallel configuration of the electrodes within the packet facilitate uniform heating of the packet's contents. | 03-14-2013 |
20130035478 | PYRROLYSINE ANALOGS - Several different pyrrolysine analogs are disclosed in this application. Those analogs have distinct chemical and biophysical properties. Some analogs are useful in chemical ligation applications. Methods of making and using are also disclosed. | 02-07-2013 |
20130022541 | FTY720 Increases CD74 Expression and Sensitizes Cancer Cells to Anti-CD74 Antibody-Mediated Cell Death - Disclosed herein are methods and compositions comprising fingolimod and anti-CD74 antibodies or fragments thereof. In preferred embodiments, the fingolimod increases the expression of CD74 in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 antibodies. The compositions and methods are of use to treat diseases involving CD74 | 01-24-2013 |
20120329836 | METHODS FOR STABILIZING HYPOXIA INDUCIBLE FACTOR-2 ALPHA AS A METHOD FOR TREATING CANCER - Disclosed herein is {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino}acetic acid and the ester and amide prodrugs thereof, that can stabilize hypoxia inducible factor-2 alpha (HIF-2α) and thereby provide a method for treating cancer. Further disclosed are compositions which comprise {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino}acetic acid and/or a prodrug thereof which can be used to treat cancer. | 12-27-2012 |
20120315642 | Primers and Methods for Nucleic Acid Amplification - A primer and method for amplification of a target nucleic acid, the primer adapted to conform into a conformation that dissociates from a complementary strand of DNA duplex. The conformation may have a free energy with more favorable thermodynamics than a corresponding DNA duplex, such as a B-DNA duplex. The dissociation may occur during an extension step of an amplification method, such as polymerase chain reaction. The method can proceed isothermally, and the primers may include intrinsic fluorescence. | 12-13-2012 |
20120295137 | CATALYSTS FOR USE IN ELECTROCHEMICAL APPLICATIONS AND ELECTRODES AND DEVICES USING SAME - An electrode for reduction of an oxidant including a phosphorus-doped carbon-containing catalyst represented by the chemical formula CN | 11-22-2012 |
20120252023 | Materials and Methods Useful for Affecting Tumor Cell Growth, Migration and Invasion - It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein. | 10-04-2012 |
20120248386 | THERMOELECTRIC MATERIALS HAVING POROSITY - A thermoelectric material and a method of making a thermoelectric material are provided. In certain embodiments, the thermoelectric material comprises at least 10 volume percent porosity. In some embodiments, the thermoelectric material has a zT greater than about 1.2 at a temperature of about 375 K. In some embodiments, the thermoelectric material comprises a topological thermoelectric material. In some embodiments, the thermoelectric material comprises a general composition of (Bi | 10-04-2012 |
20120219636 | ENHANCED REMOVAL OF VIRUSES FROM FRESH PRODUCE - A formulation and method for removing viruses from fresh produce, including at least one surfactant, and a solvent. Preferably, the formulation also includes at least one sanitizer. | 08-30-2012 |
20120215080 | APPARATUS, SYSTEM AND METHOD FOR TISSUE OXIMETRY - An apparatus, system and method for measuring oxygen concentration for exciting and detecting oxygen-sensitive fluorescence in biological tissues to detect oxygen levels (e.g., the partial pressure of oxygen). | 08-23-2012 |
20120214703 | Methods for Diagnosing Stomach Cancer Using MicroRNA Signatures - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214702 | Methods for Diagnosing Prostate Cancer Using MicroRNA Signatures - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214701 | Methods for Diagnosing Lung Cancer Using MicroRNA Signatures - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214700 | Methods for Diagnosing Colon Cancer Using MicroRNA Signatures - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214699 | Methods for Diagnosing Breast Cancer Using MicroRNA Signatures - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214698 | Methods for Diagnosing Stomach Cancer Using MicroRNAs - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214697 | Methods for Diagnosing Prostate Cancer Using MicroRNAs - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214696 | Methods for Diagnosing Pancreatic Cancer Using MicroRNAs - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214695 | Methods for Diagnosing Lung Cancer Using MicroRNAs - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214694 | Methods for Diagnosing Colon Cancer Using MicroRNAs - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214693 | Methods for Diagnosing Breast Cancer Using MicroRNAs - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214692 | Methods for Diagnosing Pancreatic Cancer Using miR-103-1, miR-103-2, miR-24-2 and miR-107 - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214691 | Methods for Diagnosing Breast Cancer Using miR-21, miR-125-1, miR-125b-2 and miR-145 - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214690 | Methods for Diagnosing Colon, Stomach, Prostate and Pancreas Cancer Using miR-223 - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214689 | Methods for Diagnosing Breast and Lung Cancer Using miR-210 and miR-213 - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120214688 | Methods for Diagnosing Breast, Colon, Lung, Pancreatic and Prostate Cancer Using miR-21 and miR-17-5p - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. | 08-23-2012 |
20120211702 | Electrically Conducting Polymer And Copolymer Compositions, Methods For Making Same And Applications Therefor - The present invention relates generally to substituted polyaniline polymer/copolymer compositions, suitable slats thereof and uses therefore. In one embodiment, the present invention relates to conductive substituted polyaniline polymer/copolymer compositions, suitable slats thereof and uses therefore. In still another embodiment, the present invention relates to self-protonated substituted polyaniline polymer/copolymer compositions, suitable slats thereof and uses therefore. In yet another embodiment, the present invention relates to self-protonated sulfonic acid- or boric acid-substituted polyaniline polymer/copolymer compositions, suitable slats thereof and uses therefore. In still another embodiment, the one or more various polyaniline polymer/copolymer compositions of the present invention are both biodegradable and conducting polymer compositions. | 08-23-2012 |
20120201841 | POLYPEPTIDES AND POLYNUCLEOTIDES FOR ENHANCING IMMUNE REACTIVITY TO HER-2 PROTEIN - Compositions for stimulating the immune system and for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include immunogenic epitopes of the HER-2 proteins and chimeric and multivalent peptides which comprise such epitopes. The present invention also relates to polynucleotides which encode the chimeric peptides. Also provided are pharmaceutical compositions comprising such immunogenic compositions. Methods for stimulating an immune response to HER-2 protein are provided. Methods for treating breast cancer, ovarian cancer, prostate cancer, colon cancer and lung cancer are provided. | 08-09-2012 |
20120199814 | SILICON-BASED TUNNELING FIELD EFFECT TRANSISTORS AND TRANSISTOR CIRCUITRY EMPLOYING SAME - A p-channel tunneling field effect transistor (TFET) is selected from a group consisting of (i) a multi-layer structure of group IV layers and (u) a multi-layer structure of group III-V layers. The p-channel TFET includes a channel region comprising one of a silicon-germanium alloy with non-zero germanium content and a ternary III-V alloy. An n-channel TFET is selected from a group consisting of (i) a multi-layer structure of group IV layers and (u) a multi-layer structure of group III-V layers. The n-channel TFET includes an n-type region, a p-type region with a p-type delta doping, and a channel region disposed between and spacing apart the n-type region and the p-type region. The p-channel TFET and the n-channel TFET may be electrically connected to define a complementary field-effect transistor element. TFETs may be fabricated from a silicon-germanium TFET layer structure grown by low temperature (500 degrees Centigrade) molecular beam epitaxy. | 08-09-2012 |
20120192617 | DETERMINING PHYSICAL PROPERTIES OF OBJECTS OR FLUIDS IN MULTI-PATH CLUTTER ENVIRONMENTS - A method for determining a physical property of an object or fluid in a dynamic multi-path clutter environment comprises transmitting an RF interrogation signal to a wireless sensor physically coupled to the object or fluid (gas or liquid) in the dynamic multi-path clutter environment, wherein the wireless sensor is operable to receive the RF interrogation signal, produce a reference signal and a measurement signal, and retransmit the reference signal and the measurement signal in the dynamic multi-path clutter environment. The reference signal and measurement signal are delayed by the wireless sensor by an amount of time that may be a function of the unknown physical property. The method also comprises receiving the retransmitted reference signal and the retransmitted measurement signal and comparing them in the time domain in order to determine the unknown physical property of the object or fluid. The method further comprises setting the time delays of the retransmitted reference and retransmitted measurement signals to be long enough for the ringdown time to be over but not so long so that the differential time is distorted by the dynamics of the system. | 08-02-2012 |
20120192605 | FERTILIZER COMPOSITION AND METHOD - Embodiments relate to a composition and method for enhancing the growth of a plant using an inoculant composition comprising an effective quantity of an algal component in conjunction with a bacterial component. | 08-02-2012 |
20120188333 | SPHERICAL VIEW POINT CONTROLLER AND METHOD FOR NAVIGATING A NETWORK OF SENSORS - An improved human-sensor system for allowing an observer to efficiently perceive, navigate, and control a sensor network. A first layer of the system is a spherical control interface that independently provides an indication of the orientation of a sensor being controlled by the interface. A second layer of the system enhances a live sensor feed by providing a virtual, environmental context when the feed is displayed to an observer. A third layer of the system allows an observer to switch from a first-person perspective view from a sensor to a third person perspective view from movable point of observation in virtual space. A fourth layer of the system provides a virtual representation of the sensor network, wherein each sensor is represented by a virtual display medium in a virtual space. A fifth layer of the system provides a methodology for navigating and controlling the virtual sensor network of Layer 4. | 07-26-2012 |
20120171663 | System for Detection of Occult Murine Cytomegalovirus (MCMV) - Methods and compositions for detecting, treating, characterizing, and diagnosing cytomegalovirus in mammals using a nested-PCR methodology using specific predesigned primers are described. | 07-05-2012 |
20120141955 | HYBRID DENTAL IMPLANT - The present invention provides for a hybrid dental implant having a screw body with at least one external thread, which comprises an upper portion with an open ceiling configured to receive an unhardened cement, a middle portion having an inner cavity and one or more side openings extending from the inner cavity, wherein the open ceiling is in communication with the inner cavity to form a hollow inner channel, which allows the unhardened cement to move through the side openings and to penetrate the surrounding bone; and a lower portion with a closed floor. It also provides for a method of installing a hybrid dental implant into a bone. | 06-07-2012 |
20120126920 | LAMINATE COMPOSITE AND METHOD FOR MAKING SAME - An organic-based magnet is formed by molecular layer deposition (MLD) of a first compound and MLD of a second compound. The first or second compound containing a metal-containing compound. The first and second compounds being reactive with each other to form a first layer organic-based magnet. A laminate composite includes a first monolayer including a metal bonded to a magnet forming organic compound. A second monolayer may be in direct contact with the first monolayer. One of the first monolayer and the second monolayer having an induced magnetization when exposed to a magnetic field. A device includes the laminate composite and a nonmagnetic film thereon. A method of making an organic magnet on a substrate in a vacuum chamber includes depositing a first layer of metal-containing compound on the substrate by MLD. | 05-24-2012 |
20120116307 | DIFFUSION DELIVERY SYSTEMS AND METHODS OF FABRICATION - The invention generally relates to diffusion delivery systems and more particularly to high precision nanoengineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems. | 05-10-2012 |
20120103949 | LASER-INDUCED METALLURGICAL BONDING DRIVEN WITHOUT CONTACT - A laser, aimed at a flyer plate tab, causes optical energy to be directed at the tab, specifically, at a top surface thereof. Energy impacting the tab accelerates the tab into an impact with a target sheet in a time on the order of about 10 | 05-03-2012 |
20120100068 | Anti-CD74 Immunoconjugates and Methods of Use - Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions. | 04-26-2012 |
20120085353 | JOINT STABILITY ARRANGEMENT AND METHOD - The stability of an animal joint, especially a knee, is assessed with an arrangement having track arranged about perpendicular to the axis of the distal portion; a cart slidably engaged to the track; a fork positioned on the cart; a support adapted to receive the distal linear portion, the support connected to the fork; a lever arm connected to the support, the lever arm positioned to rotate the support about the axis of the distal portion; and at least one instrumented handle, the instrumented handle detachably engages at least one of the cart and the lever arm. In some embodiments, the fork can rotate freely on the cart. Additionally, in various embodiments, the cart may be selectively locked at a position along the length of the track. In various embodiments, the arrangement further comprises: a bracket rigidly attached to the distal portion and positioned between the support and the joint; and the at least one instrumented handle detachably engages the bracket. | 04-12-2012 |
20120083684 | DIGITAL DISTANCE MEASURER FOR NERVE CONDUCTION STUDIES - Nerve conduction studies (NCS) are used to diagnose many types of disorders and are being employed more and more frequently. Current methods for distance measurement during a NCS are manual and often time consuming and vulnerable to considerable error. A device and system for electronically measuring distance during a NCS and automatically transferring the data is disclosed. In one embodiment, the device incorporates a contact wheel to travel across the surface of the subject's skin to measure the applicable distance. | 04-05-2012 |
20120071045 | MARINE PROPULSION SYSTEM - A marine propulsion system comprising, in one embodiment: a fuel-filled tank; an air compressor that generates compressed air; an engine that receives fuel from the tank, wherein the air compressor is powered by the engine; and at least one hot gas generator that receives compressed air from the air compressor, the hot gas generator comprising: (a) a combustion chamber having an inlet and an outlet, the compressed air injected into the combustion chamber at the inlet, the combustion chamber adapted to produce hot gas; (b) an injection nozzle that receives fuel from the tank, the injection nozzle positioned proximate to the inlet of the combustion chamber, the injection nozzle adapted to spray the fuel into the combustion chamber; and (c) an exhaust Coanda nozzle positioned at the outlet of the combustion chamber through which the hot gas produced in the combustion chamber is discharged from the hot gas generator. | 03-22-2012 |
20120035457 | ELECTROMAGNETIC SYSTEM AND METHOD - Differences of electromagnetic (EM) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying EM field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. In some aspects, a change in phase shift between the voltage in a receiver coil and the voltage in a driver coil provide a direct and immediate indication of differences in EM properties of specimens. | 02-09-2012 |
20120027753 | MicroRNAs in Never-Smokers and Related Materials and Methods - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer in never-smokers. The invention also provides methods of identifying anti-lung cancer agents. | 02-02-2012 |
20120014857 | METHODS FOR SYNTHESIZING AMMONIA BORANE - Methods of synthesizing ammonia borane are provided. The methods comprise reacting at least one amine borane with ammonia such that ammonia borane is produced. Ammonia borane has a chemical formula of NH | 01-19-2012 |
20110313675 | RAPID DIAGNOSIS OF A DISEASE CONDITION USING INFRARED SPECTROSCOPY - Reliable and rapid diagnostic methods for many functional syndromes (FS) such as Bladder Pain Syndrome/Interstitial Cystitis (IC) are not available. Exemplary embodiments include rapid and accurate methods for diagnosing FS in humans and other mammals using infrared microspectroscopy (IRMS). Exemplary methods utilize Soft Independent Modeling by Class Analogy (SIMCA) to create classification models. Exemplary methods utilize classification models to categorize a subject's condition (e.g., healthy/sick and or flare/remission). Using these classification models, various embodiments enable diagnosis based on spectra data from a blood sample or other biomedical specimen. Exemplary embodiments may be useful for rapid diagnosis of IC and various other conditions in humans, cats, and/or other mammals. | 12-22-2011 |
20110311555 | Tc11 as a Transcriptional Regulator - Methods and compositions for the diagnosis, prognosis and/or treatment of B cell chronic lymphocytic leukemia associated diseases are disclosed. | 12-22-2011 |
20110280913 | Methods and Compositions for Delivering Therapeutic Agents in the Treatment of B-Cell Related Disorders - Methods and compositions for treating and/or diagnosing a B-cell malignancy are described. | 11-17-2011 |
20110280865 | Ets-2 Biomarkers for Fibrotic Diseases and Uses Thereof - Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described. | 11-17-2011 |
20110275534 | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Ovarian Cancer Using a Real-Time PCR Platform - Methods and compositions for the diagnosis, prognosis and/or treatment of ovarian cancer are disclosed. | 11-10-2011 |
20110274718 | System for Modulating Expression of Hypothalmic Brain-Derived Neurotrophic Factor (BDNF) - Methods for treating tumor associated diseases by administering a nucleic acid sequence encoding brain derived neurotrophic factor (BDNF) where the expression reduces the symptoms of the disease and compositions for mediation of enrichment-induced tumor resistance having brain derived neurotrophic factor (BDNF) are disclosed. | 11-10-2011 |
20110250608 | USE OF ULTRACONSERVED RNA IN DETECTION AND TREATMENT OF CANCER - A method of analyzing a biological specimen to detect cancer in a subject, involving determining an ultraconserved RNA in the specimen and comparing the expression level to a control. The ultraconseved RNA may be uc.338 and may be used to detect hepatocellular cancer. Transcript RNA encoding ultraconserved RNA may also be used to detect cancer. Anti-cancer compositions and tumor-suppressing agents for treating cancer are also provided. | 10-13-2011 |
20110248209 | THERMOELECTRIC FIGURE OF MERIT ENHANCEMENT BY MODIFICATION OF THE ELECTRONIC DENSITY OF STATES - A thermoelectric material and a method of using a thermoelectric material is provided. The thermoelectric material can include at least one compound. For example, the at least one compound may be a Group IV-VI compound such as lead telluride. The at least one compound may further include one or more dopants such as sodium, potassium, and thallium. The method of using a thermoelectric material can include exposing at least one portion of the at least one compound to a temperature greater than about 700 K. | 10-13-2011 |
20110190383 | Diagnostic, Prognostic and Therapeutic Uses of MIRs in Adaptive Pathways and/or Disease Pathways - Described herein are methods and compositions for the diagnosis, prognosis and treatment of various adaptive and/or of disease pathways by examining samples containing one or more miRs therein, and by formulating therapeutic agents therefrom. | 08-04-2011 |
20110190160 | MicroRNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF LUNG CANCER USING MIR-21 - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provides methods of identifying anti-lung cancer agents. | 08-04-2011 |
20110177968 | MicroRNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF LUNG CANCER USING MIR-17-3P - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provides methods of identifying anti-lung cancer agents. | 07-21-2011 |
20110168897 | RAPID DIAGNOSIS OF A DISEASE CONDITION USING INFRARED SPECTROSCOPY - Reliable and rapid diagnostic methods for many functional syndromes (FS) such as Bladder Pain Syndrome/Interstitial Cystitis (IC) are not available. Exemplary embodiments include rapid and accurate methods for diagnosing FS in humans and domestic cats using infrared microspectroscopy (IRMS). Exemplary methods utilize Soft Independent Modeling by Class Analogy (SIMCA) to create classification models. Exemplary methods utilize classification models to classify a test subject's condition (e.g., healthy/sick). Using these classification models, various embodiments enable diagnosis based on spectra data from a fluid biomedical specimen. Exemplary embodiments may be useful to rapidly diagnose IC and various other conditions in humans, cats, and/or other mammals. | 07-14-2011 |
20110152357 | Micro-RNA-Based Compositions and Methods for the Diagnosis, Prognosis and Treatment of Multiple Myeloma - Methods for assessing a pathological condition in a subject includes measuring an expression profile of one or more markers where a difference is indicative of multiple myeloma (MM) or a predisposition to MM. The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of MM. The invention also provides methods of identifying anti-MM cancer agents. | 06-23-2011 |
20110151529 | METHODS AND PROCESSES FOR PRODUCING ORGANIC ACIDS - A fermentation process for the production of organic acids is provided and includes, providing metabolically engineered mutant bacteria which have had one or both of ack and pta genes disrupted, adapting the mutant bacteria to increase their resistance to acids and to increase their growth rate by immobilizing the mutant bacteria while exposing the mutant bacteria to a fermentable substrate, and further exposing the adapted mutant bacteria to a fermentable substrate for a time sufficient to provide a final organic acid fermentation product concentration of greater than about 50 g/L. | 06-23-2011 |
20110151061 | FOOD DECORATION - Various embodiments relate to a method and an arrangement for printing an indicium onto an edible media. In some embodiments, the film is affixed onto a support material. In various embodiments, the film comprises a chitosan polymer. In other embodiments, the film comprises a blend of protein, polysaccharides, and lipids instead of chitosan. | 06-23-2011 |
20110124521 | Use of MiR-26 Family as a Predictive Marker for Hepatocellular Carcinoma and Responsiveness to Therapy - It is disclosed herein that expression of microRNA-26 is decreased in hepatocellular (HCC) tumor tissue relative to non-cancerous tissue, and that a low level of microRNA-26 is associated with a poor clinical outcome. It is also disclosed herein that a low expression level of microRNA-26 is correlated with a favorable response to interferon (IFN)-α therapy in HCC patients. Thus, provided herein is a method of predicting the clinical outcome of a patient diagnosed with HCC comprising detecting the level of microRNA-26 expression in a sample obtained from the patient. Also provided is a method of selecting a patient diagnosed with HCC as a candidate for IFN-α therapy, comprising detecting the level of microRNA-26 expression in a sample obtained from the patient. A method of identifying therapeutic agents for the treatment of HCC, comprising screening candidate agents in vitro to select an agent that increases expression of microRNA-26 in HCC cells are also provided. Further provided are methods of treating a patient diagnosed with HCC and expressing a low level of miR-26, wherein treatment comprises IFN-α therapy. | 05-26-2011 |
20110124077 | MOBILE MAGNETIC TRAPS AND PLATFORMS FOR MICRO/NANO PARTICLE MANIPULATION - Magnetic array platforms such as nano or micro-wire networks that produce trapping, manipulation, and transport of micro- or nano-scale particles such as non-biological entities such as magnetic particles and cells, viruses, DNA, proteins, and other biological entities having magnetic particles labeled or tethered thereto are provided. Methods of manipulating, transporting, and sorting micro- or nano-scale particles are described. | 05-26-2011 |
20110104069 | MULTI-FUNCTIONAL BIODEGRADABLE PARTICLES FOR SELECTABLE TARGETING, IMAGING, AND THERAPEUTIC DELIVERY AND USE THEREOF FOR TREATING OCULAR DISORDERS - In various embodiments, provided are multi-functional biodegradable particles for selectable targeting, imaging, and delivery of therapeutic agents. Also provided are methods of using the provided particles for treatment of ocular disorders, such as for the treatment of age-related macular degeneration. The provided particles and methods provide a clinician with options for control over, and monitoring of, the delivery of therapeutic agents. | 05-05-2011 |
20110070782 | MARINE PROPULSION SYSTEM - A marine propulsion system comprising: a fuel-filled tank; an air compressor that generates compressed air; an engine that receives fuel from the tank, wherein the air compressor is powered by the engine; and at least one hot gas generator that receives compressed air from the air compressor, the hot gas generator comprising: (a) a combustion chamber having an inlet and an outlet, the compressed gas injected into the combustion chamber at the inlet, the combustion chamber adapted to produce hot gas; (b) an injection nozzle that receives fuel from the tank, the injection nozzle positioned proximate to the inlet of the combustion chamber, the injection nozzle adapted to spray the fuel into the combustion chamber; and (c) an exhaust nozzle positioned at the outlet of the combustion chamber through which the hot gas produced in the combustion chamber is discharged from the hot gas generator. | 03-24-2011 |
20110064797 | CAPSULE OF THERMOGENIC CELLS FOR TREATING A METABOLIC DISEASE - Described herein are methods and devices for treating a metabolic disease that involve implanting a micro-device into a tissue of a subject having a metabolic disease. The micro-device includes a plurality of thermogenic cells encapsulated in a biocompatible capsule. The capsule includes a core to accommodate the plurality of thermogenic cells and a porous immunoprotective membrane that allows for metabolic interaction between the plurality of thermogenic cells and the tissue. | 03-17-2011 |
20110000953 | LOW-TEMPERATURE SPOT IMPACT WELDING DRIVEN WITHOUT CONTACT - A laser, aimed at a flyer plate tab, causes optical energy to be directed at the tab, specifically, at a top surface thereof. Energy impacting the tab accelerates the tab out of an initial bent position, straightening it into an impact with a target sheet. The impact occurs in excess of 100 m/s, resulting in a metallurgical bond between the tab and the target sheet. The laser preferably strikes the top surface in a normal direction, based upon an initial angularity of the tab relative to the target. The laser emission, preferably in the range of 1 to 100 Joules delivered in a microsecond, may be augmented by an ablative layer on the top surface or a transparent covering on the top surface that reacts against the expanding gas from ablative activity on the top surface. The weld is formed without physical contact between the welding device and the tab. | 01-06-2011 |
20110000022 | Portable Extremity Assessment And Management Device - A device and method for elevating and supporting a patient's extremity to facilitate convenient examination and treatment of the extremity. The device includes a base, longitudinally-spaced upstanding support members extending upwardly from the base, and extremity securing mechanisms mounted to the upstanding support members upon which a patient's extremity can be positioned. The method generally includes extending a patient's extremity longitudinally across the extremity securing mechanisms and bringing the extremity to rest thereon. Caregivers and surgical teams are thus provided with access to the full circumference of the portion of the patient's extremity that extends between the extremity securing mechanisms. Several embodiments of the device incorporate means for assisting in the lifting of a patient's extremity to a desired height, including hydraulic rams, levers, and inflatable bladders. | 01-06-2011 |
20100301217 | MINIATURE PHASE-CORRECTED ANTENNAS FOR HIGH RESOLUTION FOCAL PLANE THz IMAGING ARRAYS - An array of backward diodes of a cathode layer adjacent to a first side of a non-uniform doping profile and an Antimonide-based tunnel barrier layer adjacent to a second side of the spacer layer have a monolithically integrated antenna bonded to each backward diode. The Antimonide-based tunnel barrier may be doped with, for example, a non-uniform delta doping profile. An imaging/detection device includes a 2D focal plane array of an array of backward diodes, wherein each backward diode is monolithically bonded to an antenna, which array is located at the back of an extended hemispherical lens, and wherein certain of the arrays are tilted for correcting optics aberrations. The antennas may be a bow-tie antenna, a planar log-periodic antenna, a double-slot with microstrip feed antenna, a spiral antenna, a helical antenna, a ring antenna, a dielectric rod antenna, or a double slot antenna with co-planar waveguide feed antenna. | 12-02-2010 |
20100286232 | MICRORNA EXPRESSION PROFILE ASSOCIATED WITH PANCREATIC CANCER - Methods are provided for diagnosing whether a subject has, or is at risk of developing, pancreatic cancer. The methods include measuring the level of at least one miR gene product in a biological sample derived from the subject's pancreas. An alteration in the level of the miR gene product in the biological sample as compared to the level of a corresponding miR gene product in a control sample, is indicative of the subject either having, or being at risk for developing, pancreatic cancer. | 11-11-2010 |
20100273258 | Interactive Microenvironment System - A culture cell for growing animal cells in vitro has sides and a bottom forming a volume. The volume contains a layer of nanofiber upon which animal cells can be cultured. The layer of nanofiber can be oriented or non-oriented. Multiple layers can be placed in the volume, where the layers have different composition and/or different porosity. The nanofiber can be, for example, surface treated or of a core-shell construction. | 10-28-2010 |
20100272636 | Anti-CD74 Immunoconjugates and Methods of Use - Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions. | 10-28-2010 |
20100258154 | THERMOELECTRIC ALLOYS WITH IMPROVED THERMOELECTRIC POWER FACTOR - A thermoelectric material and a method of using a thermoelectric device are provided. The thermoelectric material includes at least one compound having a general composition of (Bi | 10-14-2010 |
20100234588 | SYNTHETIC METHOD FOR CERATAMINE A AND B AND ANALOGS THEREOF - Methods are provided for preparing compounds of the general formula (I) | 09-16-2010 |
20100227776 | Rapid Genotyping of SNPs - Embodiments include a universal and generic method for rapidly genotyping essentially any single nucleotide polymorphism (SNP) and or other polymorphism. Various embodiments include procedures for SNP and/or allele analysis that are easy, cheap, highly multiplexable, easily automatable, and lend themselves to high-throughput. Embodiments are broadly applicable for all applications where SNP determinations are useful. | 09-09-2010 |
20100190703 | PEPTIDES SPECIFIC FOR HUMAN BLOOD OUTGROWTH ENDOTHELIAL CELLS - Provided herein are compositions and methods for binding outgrowth endothelial cells (OEC). The compositions consist of peptide ligands capable of binding OEC with high affinity and specificity. The compositions of the invention include peptides set forth in SEQ ID NO: 1-38 and variants and derivatives thereof. Compositions also include the nucleotide sequences encoding the peptides of the invention. The compositions find use in methods for the isolation of OEC and for the recruitment and retention of OEC to sites of therapeutic interest. Methods for the identification and isolation of other peptides capable of binding OEC are also provided. | 07-29-2010 |
20100124773 | METHODS AND PROCESSES FOR PRODUCING ESTERS - Methods are provided for producing esters. The methods comprise converting a fermentable carbon source to organic acids by fermentation with organic acid producing microorganisms, followed by catalytic esterification. The methods comprise integrated fermentation, extraction, and esterification reactions wherein the organic acids produced during fermentation are extracted into an extraction solvent and then directly reacted with an alcohol in the presence of a catalyst to form organic esters. Methods of producing esters are also provided wherein the organic acids produced during fermentation and extracted into the extraction solvent are stripped from the extraction solvent prior to being reacted with an alcohol in the presence of a catalyst to form organic esters. | 05-20-2010 |
20100112071 | POLYPEPTIDES AND POLYNUCLEOTIDES FOR ENHANCING IMMUNE REACTIVITY TO HER-2 PROTEIN - Compositions for stimulating the immune system and for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include immunogenic epitopes of the HER-2 proteins and chimeric and multivalent peptides which comprise such epitopes. The present invention also relates to polynucleotides which encode the chimeric peptides. Also provided are pharmaceutical compositions comprising such immunogenic compositions. Methods for stimulating an immune response to HER-2 protein are provided. Methods for treating breast cancer, ovarian cancer, prostate cancer, colon cancer and lung cancer are provided. | 05-06-2010 |
20100097374 | 3D AND REAL TIME ELECTRICAL CAPACITANCE VOLUME-TOMOGRAPHY SENSOR DESIGN AND IMAGE RECONSTRUCTION - Dynamic three-dimensional image electrical capacitance tomography sensor system is disclosed. The technique generates, from the measured capacitance, a whole volume image of the region enclosed by the a geometrically three-dimensional capacitance sensor. A real time, three-dimensional imaging of a moving object or a real time volume imaging (i.e., four-dimensional (4D)) allows for a total interrogation scheme of the whole volume within the domain of an arbitrary shape of geometry to be implemented. The system comprises a 3D capacitance sensor, data acquisition electronics and the image reconstruction algorithm which enables the volume-image reconstruction. The electrode shape of the capacitance sensor can be rectangular, triangular, trapezium, or any shape to enclose a 3D section of the measuring domain and to distribute the electrical field intensity in three directions with equal sensitivity strength. The image reconstruction algorithm reconstructs simultaneously the image voxels in a three-dimensional array. The tomography sensor system may be multimodal. | 04-22-2010 |
20100093052 | MAGNETIC CELL SEPARATION - Systems and methods are provided separating a first group of cells from a mixture of at least first and second groups of cells in a suspending fluid. The system includes an annular flow channel and at least one magnetic element positioned around the exterior of the annular flow channel as to provide a radially symmetric magnetic field around at least a portion of the annular flow channel. The at least one magnetic element is configured to provide a gradually increasing magnetic field along the axis of flow as to limit the maximum magnetic gradient within the annular flow channel. A pump is operatively connected to a terminal end of the annular flow channel to force the suspending fluid through the annular channel. | 04-15-2010 |
20100071556 | STABLE SUPPORTED Pd-ALLOY MEMBRANES - A Pd alloy membrane and method of making are described. | 03-25-2010 |
20100056800 | METHOD OF SYNTHESIZING 1H-INDAZOLE COMPOUNDS - A method is provided for synthesizing 1H-indazole compounds in which aromatic carbonyl compounds are reacted with a nitrogen source to form oximes which are then converted to 1H-indazoles. | 03-04-2010 |
20100028604 | HIERARCHICAL STRUCTURES FOR SUPERHYDROPHOBIC SURFACES AND METHODS OF MAKING - Embodiments of a superhydrophobic structure comprise a substrate and a hierarchical surface structure disposed on at least one surface of the substrate, wherein the hierarchical surface structure comprises a microstructure comprising a plurality of microasperities disposed in a spaced geometric pattern on at least one surface of the substrate. The fraction of the surface area of the substrate covered by the microasperities is from between about 0.1 to about 1. The hierarchical structure comprises a nanostructure comprising a plurality of nanoasperities disposed on at least one surface of the microstructure. | 02-04-2010 |
20090263316 | HIGH PURITY, HIGH PRESSURE HYDROGEN PRODUCTION WITH IN-SITU CO2 AND SULFUR CAPTURE IN A SINGLE STAGE REACTOR - A process for producing hydrogen, comprising the steps of: (a) gasifying a fuel into a raw synthesis gas comprising CO, hydrogen, steam and sulfur and halide contaminants in the form of H | 10-22-2009 |
20090261026 | BI-PHASIC BIORETENTION SYSTEM - An anaerobic to aerobic sequence enhances biological degradation of many organic pollutants. Exemplary embodiments provide systems and methods for effective treatment of storm-water runoff pollutants such as hydrocarbons, nitrates, phosphorus, and heavy metals using sediment filtration and adsorption, and biochemical processes under bi-phasic bioretention conditions. By integrating these pollution cleanup pro-usages into a single unit, this apparatus optimizes retention time of the runoff through the system and maximizes removal rates of runoff pollutants, resulting in more reliable and efficient treatment mechanism than previous systems. | 10-22-2009 |
20090259121 | SYSTEM AND METHOD FOR CARDIOVASCULAR EXERCISE STRESS MRI - A system and method for cardiovascular exercise stress magnetic resonance using a MRI-compatible treadmill and real-time imaging. The treadmill comprises non-ferromagnetic components so that it may be used in proximity to a MRI scanner. The treadmill is positioned adjacent to the MRI scan table. A treadmill control system is used to control the speed and grade of the treadmill to allow it to perform a wide range of exercise protocols. Patients complete an exercise protocol on the treadmill and are then moved to the MRI scan table. Images are acquired as quickly as possible post-exercise to more accurately diagnose cardiovascular disease in patients. | 10-15-2009 |
20090222934 | Pre-B Cell Proliferation and Lymphoblastic Leukemia/High-Grade Lymphoma in MIR155 Transgenic Mice - A transgenic non-human animal, such as a mouse, has a genome that include a nucleic acid construct having at least one transcriptional regulatory sequence capable of directing expression in B cells of the animal, wherein the transcriptional regulatory sequence is operably linked to a nucleic acid encoding a miR155 gene product. A method of testing the therapeutic efficacy of an agent in treating or preventing a lymphoproliferative condition includes assessing the effect(s) of the agent on a transgenic non-human animal. | 09-03-2009 |
20090209450 | MicroRNA Fingerprints During Human Megakaryocytopoiesis - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer and myeloproliferative disorders. The invention also provides methods of identifying anti-cancer agents. | 08-20-2009 |
20090208417 | Detection and Localized Imaging of Cancer Using X-Ray Fluorescent Nanoparticle/Preferential Locator Conjugates - A method for detecting gold or other nanoparticles conjugated to preferential locators commences by contacting tissue suspected of being neoplastic with gold nanoparticle/preferential locator conjugates for a time adequate for the conjugates to bind with the tissue. A beam of gamma photons (such as from, | 08-20-2009 |
20090130166 | SYSTEM FOR PROVIDING IMPLANT COMPATIBILITY WITH RECIPIENT - A system for providing or enhancing compatibility between an implant and a recipient. The system includes a recipient, typically a living biological organism, that further includes a target region; an implant having a first attraction means; and a plurality of cells. The cells are compatible with the target region and further include a second attraction means responsive to the first attraction means. The interaction between the first and second attraction means attaches the cells to the implant. | 05-21-2009 |
20080312162 | Methods and Compositions for Enzyme-Specific Activation of Carbohydrate-Conjugated Prodrugs - Methods for the targeted activation of prodrugs by enzymes, which cleave a linkage between a carbohydrate conjugate and a drug. Means to target the activation of prodrugs to specific cells by linking the enzyme to an antibody molecule. Carbohydrate conjugates of geldanamycin. | 12-18-2008 |
20080306018 | Micro-Rna Expression Abnormalities of Pancreatic, Endocrine and Acinar Tumors - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic cancer agent. | 12-11-2008 |
20080306017 | Microrna-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Lung Cancer - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provide methods of identifying anti-lung cancer agents. | 12-11-2008 |
20080306006 | MicroRna-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Solid Cancers - The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provide methods of identifying inhibitors of tumorigenesis. | 12-11-2008 |
20080300485 | ULTRASONIC SYSTEM AND METHOD FOR MEASUREMENT OF OCULAR BIOMECHANICS - A system and a method for non-invasively ultrasonically measuring biomechanical properties of ocular tissue in vivo is presented. The method comprises positioning an ultrasonic transducer proximally to the ocular tissue. Reflections of the ocular tissue can be ultrasonically obtained using the ultrasonic transducer. The ultrasonic reflections can be converted into reflection spectra. Biomechanical properties of the ocular tissue, such as, for example, thickness, corneal stiffness, density, and longitudinal modulus, can be determined based on the reflection spectra. A wave propagation model can be developed to simulate ultrasound propagation of ocular tissue in vivo. The ultrasonic non-destructive evaluation method and system for the non-invasive measuring of reflection spectra and determining biomechanical properties of ocular tissue in vivo can provide information for ocular disease management and therapeutic and refractive procedures. | 12-04-2008 |
20080261908 | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer - The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of breast cancer. The invention also provides methods of identifying anti-breast cancer agents. | 10-23-2008 |
20080260230 | Method and Apparatus for Detecting Intraventricular Dyssynchrony - A method and apparatus for detecting intraventricular dyssynchrony is provided. In one embodiment, the method includes: a) receiving information from an observer viewing a source image to define a plurality of points associated with muscle boundaries of a ventricle, b) extracting muscle boundaries for a series of source images to define a corresponding series of contour shape images using a Fourier descriptor model, and c) deforming each contour shape based at least in part on image forces, external forces, and internal forces to track movement of the muscle boundaries over time. In another embodiment, the method includes: a) characterizing the series of source images as a corresponding series of contour shape images representative of movement of muscle boundaries of the ventricle over time, b) classifying the series of contour shape images in a dyssynchronous class or a non-dyssynchronous class, and c) pre-diagnosing the ventricle as dyssynchronous or non-dyssynchronous. | 10-23-2008 |
20080253638 | Method and Apparatus for Detecting Interventricular Dyssynchrony - Several embodiments of a method and apparatus for detecting interventricular dyssynchrony are provided. In one embodiment, the apparatus includes an image segment processor and an image classifier. The image segment processor may segment left and right ventricles in source images of a subject's heart to form left and right ventricle segments in segmented images. Each source image may include cross sections of the right and left ventricles in common spatial relation along the short axis plane and in common temporal relation in reference to a cardiac cycle. The source images and corresponding segmented images may be temporally-spaced in relation to the cardiac cycle. The image classifier may determine first and second cross-sectional areas associated with the left and right ventricle segments for each segmented image, compare the first and second cross-sectional areas, and classify the subject's heart in an interventricular dyssynchronous class or a non-dyssynchronous class. | 10-16-2008 |
20080248540 | METHODS OF PRODUCING BUTANOL - A method of producing butanol from carbohydrates is provided. A feedstock comprising a carbohydrate source is fermented in the presence of bacteria to produce butyric acid and hydrogen. The butyric acid is then hydrogenated in the presence of a catalyst to produce butanol. | 10-09-2008 |
20080233564 | Methods of Using Databases to Greate Gene-Expression Microarrays, Microarrays Greated Thereby, and Uses of the Microarrays - Methods of preparing biological databases, and databases prepared according to those methods. In some embodiments, the methods can be performed entirely using computer resources, relying solely on publicly available biological sequence information. The methods of the invention can be used to generate species-specific nucleic acid microarrays | 09-25-2008 |
20080233045 | Catalyst for Hydrogen Production From Water Gas Shift Reaction - Fe—Al—Cu catalysts have numerous industrial applications, for example, as catalysts in a water gas shift reactor. A method of producing a Fe—Al—Cu catalyst comprises the steps of providing an organic iron precursor, dissolving the organic iron precursor in a solvent solution, adding an aqueous solution comprising aluminum nitrate and copper nitrate to the organic iron pre-cursor-solvent solution, precipitating a gel comprising Fe—Al—Cu by adding a base, and drying the gel to form the Fe—Al—Cu catalyst. | 09-25-2008 |
20080233029 | Separation of Carbon Dioxide (Co2) From Gas Mixtures By Calcium Based Reaction Separation (Cars-Co2) Process - A reaction-based process has been developed for the selective removal of carbon dioxide (CO | 09-25-2008 |
20080206736 | FLAVIN N-OXIDES: NEW ANTI-CANCER AGENTS AND PATHOGEN ERADICATION AGENTS - Compounds comprising flavin N-oxides for treatments of solid tumors, non-solid tumor masses, leukemias, and non-small cell lung cancers and for eradicating contaminants in blood products. Methods of treating patients having solid type cancers comprising administering a therapeutically effective amount of a flavin N-oxide to a subject in need of treatment and exposing the flavin N-oxide to an activator such that activation of the flavin N-oxide results in damage to the DNA in the cancer cells without substantial damage to the DNA of normal cells are also provided. Methods of using a flavin N-oxide as part of a combination therapy with chemotherapy, radiation therapy, or both are also provided. Methods of reducing pathogenic bacterial or viral contamination in a composition comprising a) mixing the composition with an efficacious amount of a flavin N-oxide and b) exposing the mixture of the composition and the flavin N-oxide to an activator for a period of time sufficient to activate the flavin N-oxide such that the flavin N-oxide reduces the contamination in the composition are also provided. Preferably, the composition is a blood product selected from plasma, platelets, and red blood cells and the activator is an enzyme. | 08-28-2008 |
20080198074 | RECONFIGURABLE ANTENNA USING ADDRESSABLE PIXEL PISTONS - An antenna made up of addressable conductive segments, or pixel elements, affixed to the top of each piston in a piston array is presented. The pixel elements can be activated in less than a millisecond to form an antenna array and transmission line pattern using movable pistons and a two-dimensional actuator. Each piston comprises a handle, a bottom conductive segment affixed to the top of the handle, a dielectric segment affixed to the uppermost surface of the bottom conductive segment, and a top conductive segment affixed to the uppermost surface of the dielectric segment. When the piston is not actuated, the top conductive segment forms part of a ground plane. The top conductive segment form part of the transmission line and antenna array patterns, the dielectric segment becomes a dielectric space and the bottom conductive segment forms part of the ground plane when the piston is actuated. | 08-21-2008 |