20130274143 | USE OF DETECTOR RESPONSE CURVES TO OPTIMIZE SETTINGS FOR MASS SPECTROMETRY - Processes for identifying optimal mass spectrometer settings to produce the greatest confidence in sample constituent detection are provided. Data obtained on a mass spectrometer are analyzed by a quadratic variance function which accurately represents intensity variation as a variation of peak intensity. This function is then used to identify intensities that possess a minimum coefficient of variation that is useful for identifying optimal mass spectrometer settings. Inventive processes involve using a general purpose computer to identify optimal mass spectrometer settings for use in biomarker analyses, for optimizing peak detection and biomarker identification in a biological sample. The inventive processes provide for improved methods of identifying new biomarkers as well as screening subjects for the presence or absence of disease or biological condition. | 10-17-2013 |